ライフサイエンスコーパス: immortalize

1 s and promote migration and invasion in both immortalized and cancerous prostate cells.

2 Immortalized and malignant EBV-carrying B-cell lines wer

3 ows much higher throughput when transfecting immortalized and primary cells compared with more conven

4 and sustained transcriptional activation in immortalized and primary human cells.

5 We show, using immortalized and primary keratinocytes, that S. aureus p

6 ate the metabolic implications of FH loss in immortalized and primary mouse kidney cells.

7 ) and upregulation of interleukin (IL)-17 in immortalized and primary patient-derived malignant and n

8 cells from two people exposed to DENV4 were immortalized and screened to identify DENV-specific clon

9 to increased autophagic flux in both normal-immortalized and tumor-derived cell lines.

10 ones, histone variants, and PTMs in primary, immortalized, and transformed cells.

11 1970s when Georges Kohler and Cesar Milstein immortalized antibody-producing mouse B-lymphocytes by f

12 induced chromatin relaxation and observed in immortalized as compared to normal cellular states.

13 Engagement of both the BCR and CR3, on immortalized as well as primary murine B cells and human

14 t lipoprotein particle standards produced by immortalized astrocytes.

15 ae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species but that

16 V-2 isolates, compromised in the capacity to immortalize B cells, infect CD3(+) T cells ex vivo and p

17 for HPA-1a, named 26.4, was derived from an immortalized B cell from an alloimmunized woman who had

18 nant hyperthermia-susceptible lymphocytes or immortalized B cells relative to controls.

19 NFkappaB and is critical for survival of EBV-immortalized B cells.

20 LMP1, LMP2A, and LMP2B transcription in EBV-immortalized B lymphocytes.

21 e used iPSCs derived from Epstein-Barr virus-immortalized B-lymphocytes to verify that the hyperexcit

22 hagy and inhibited growth in Ras-transformed immortalized Baby Mouse Kidney (iBMK) ATG5(+/+) but not

23 We showed that telomerase-immortalized Ben-Men-1 benign meningioma cells harbored

24 99.52% of BCa cells, but only 47.47% of the immortalized benign bladder epithelial cells.

25 This was in contrast to what was observed in immortalized benign human prostate cells and a testoster

26 Cai and adenosine were measured in fresh or immortalized blood lymphocytes incubated with 0-10 mM 4-

27 ell-based microarray assays utilizing murine immortalized bone marrow (BaF3) cells were developed to

28 ncer cell line, and MCF10A, a nontumorigenic immortalized breast cell line.

29 DR77 in breast cancer cell lines relative to immortalized breast epithelial cells.

30 ntial to enhance the cell viability of human immortalized bronchial epithelial cell line of Beas-2B.

31 Analyses in BEAS-2B immortalized bronchial epithelial cells showed rapid PTP

32 ensitivity to otherwise resistant telomerase-immortalized bronchial epithelial cells.

33 red the inducible activation of oncogenes in immortalized bronchial epithelial cells.

34 ma cells, stable overexpression of BAP1 into immortalized but non-transformed melanocytes did suppres

35 orced expression of MCM8 in RWPE1 cells, the immortalized but non-transformed prostate epithelial cel

36 ndent fibulin-2 expression occurred in cells immortalized by either SV40 large T antigen or p53-null

37 ayed culture wound closing in three types of immortalized cancer cell lines.

38 HMMR over-expression in immortalized cancer cells induces phenotypes consistent

39 AS activation does not cooperate with MA4 to immortalize CD34(+) HSPCs.

40 ophagy in HTLV-1-transformed T cells and Tax-immortalized CD4 memory T cells.

41 to rodent models, we explored the use of an immortalized cell line derived from human dorsal root ga

42 Here, we use Oli-neu cells, an immortalized cell line derived from primary murine oligo

43 resident immune cells of the brain, and the immortalized cell line of human microglia-SV40.

44 studies in UB/OC-1 cells, an organ of Corti immortalized cell line, showed that R-PIA reduced cispla

45 sosomal phenotypes and cell toxicity in both immortalized cell lines and neurons.

46 -based ontology that contains information of immortalized cell lines and relevant experimental compon

47 Ectopically expressed NLRP2 in immortalized cell lines assembles an inflammasome and in

48 ansforming primary human CD4(+) T cells into immortalized cell lines indistinguishable from patient-d

49 logical assays that have been performed with immortalized cell lines to be applied to spheroids.

50 A panel of immortalized cell lines was challenged with the RAD51-st

51 ng (ChIP-seq) analyses have focused on a few immortalized cell lines whose activities and physiology

52 ads from 46 primary cell types, 42 cancer or immortalized cell lines, and 26 tissues.

53 cell culture tools, including primary cells, immortalized cell lines, human stem cells, and their mor

54 ompetent primary sheep endothelial cells and immortalized cell lines.

55 ial agents when delivering genes to multiple immortalized cell lines.

56 A knockdown was employed in human normal and immortalized cell lines.

57 HDR studies have focused on transformed and immortalized cell lines.

58 ition characteristic of fibroblasts and many immortalized cell lines.

59 h were recurrently affected in the set of 25 immortalized cell lines.

60 (BCL-2) to early-infected (MCL-1/BCL-2) and immortalized cells (BFL-1).

61 This analysis revealed that common immortalized cells are related to adult muscle precursor

62 The immortalized cells differentiate efficiently into mature

63 cells is smaller than that produced in other immortalized cells due to cleavage.

64 The immortalized cells had a signature comparable to MDV-tra

65 In addition, in contrast to drug-treated, immortalized cells in vitro, mature motor neurons rarely

66 Patient-derived cells as well as immortalized cells in which PARN is disrupted show decre

67 Remarkably, the immortalized cells retained the capacity for myogenic di

68 t 100-fold more selective for AML than solid immortalized cells such as HEK293 or human peripheral bl

69 Notably, unlike immortalized cells, all treated cell populations eventua

70 nuous expression of cooperating oncogenes in immortalized cells, although essential for anchorage-ind

71 models tested (e.g., between primary cells, immortalized cells, and in cocultures of immortalized hu

72 nd differentiation potential, or have become immortalized cells.

73 al AAV serotypes and a number of primary and immortalized cells.

74 as shown to induce tumorigenic phenotypes in immortalized cells.

75 established as a potent hCAR deactivator in immortalized cells; whether it inhibits hCAR activity un

76 heir ability to increase the permeability of immortalized choroid plexus epithelium monolayers in vit

77 Here we successfully "pseudo-immortalized" cochlear progenitor cells using the "condi

78 Human telomerase immortalized corneal epithelial (hTCEpi) cells were used

79 Human immortalized dental pulp cells were driven toward an odo

80 In contrast, immortalized DPCs have high resemblance to intact dermal

81 We have taken an alternative approach, immortalizing early adult erythroblasts generating a sta

82 ion of preneoplastic epithelial cells is not immortalizing, EBV can modulate oncogenic and cell death

83 iques were used to examine miR expression in immortalized esophageal epithelia (IEE) and esophageal a

84 on of AKT signaling in cancer cell lines and immortalized esophageal epithelial cells.

85 The immortalized expression proved a powerful confirmation o

86 e generated either from double back-cross of immortalized F2 (IF2) to the two parents, from random-cr

87 For example, when analyzing the same immortalized F2 rice population genotypic data examined

88 lecules were evaluated for two conditionally immortalized fetal NSC lines derived from the cortical a

89 ts (TDLUs), and overexpression of miR-132 in immortalized fibroblasts and in fibroblasts co-cultured

90 Viral entry into TAg-immortalized fibroblasts could largely be rescued by PDG

91 a overexpression in either HeLa cells or TAg-immortalized fibroblasts, suggesting additional restrict

92 ld-type YAP, or constitutively active YAP in immortalized FTSECs, induced cell proliferation, migrati

93 One technique involves immortalizing GAL4 expression in neuroblasts and their d

94 Primary and immortalized GAR22beta(-/-) Sertoli cells moved faster t

95 exogenous GDF9 induced FSHbeta expression in immortalized gonadotropes and in mouse primary pituitary

96 We observed that knockdown of AE2 sensitized immortalized H69 human cholangiocytes to not only bile s

97 single-cell movement and signaling in human immortalized HaCaT keratinocytes treated with soluble or

98 able tissues from genetically engineered and immortalized HEK293 cells with well-characterized electr

99 the mechanism by which that occurs, using an immortalized hematopoietic progenitor cell line, EML-C1,

100 rogression, we performed in vitro studies on immortalized hepatic stellate cells (LX-2).

101 An immortalized hepatocyte cell line (HHL-17) stably expres

102 ach, we generated and subsequently subjected immortalized heterozygous R349P desmin knock-in myoblast

103 d found that ectopic expression of TRIM24 in immortalized HMECs (TRIM24 iHMECs) greatly increased cel

104 36, increased proliferation and migration of immortalized HOSE cell lines.

105 Primary human HSCs and immortalized HSCs (LX2 cells) were incubated with condit

106 lthough the MLL-CHD fusion protein failed to immortalize HSPCs in myeloid conditions in vitro, it cou

107 e required to maintain telomere function and immortalize human cells with limited lifespan.

108 The ARAF mutations were shown to transform immortalized human airway epithelial cells in a sorafeni

109 In immortalized human airway smooth muscle (ASM) cells, Sul

110 ls, immortalized cells, and in cocultures of immortalized human and murine cells).

111 tion thrombin directly injured conditionally immortalized human and rat podocytes.

112 t-Jakob disease are taken up and degraded by immortalized human astrocytes similarly to abnormal PrP

113 devised a strategy to generate conditionally immortalized human beta cell lines based on Cre-mediated

114 We determined, using immortalized human breast epithelial cells, that elevate

115 ty of (a) an in vitro model using hTERT/Cdk4 immortalized human bronchial epithelial cell lines to id

116 inesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells (HBEC) by

117 titutively increased 5-20-fold in hTERT/CDK4-immortalized human bronchial epithelial cells (HBECs) be

118 Telomerase immortalized human bronchial epithelial cells (HBECs) wi

119 2C also influences lysosomal organization in immortalized human bronchial epithelial cells (HBECs).

120 owever, have been hampered by the lack of an immortalized human cell line derived from oligodendrocyt

121 sing for the identified compounds in several immortalized human cell lines as well as normal diploid

122 Ectopic expression of PGBD5 in primary immortalized human cells was sufficient to promote cell

123 on the integrity of tight monolayers of the immortalized human cerebral microvascular endothelial ce

124 experiments were carried out with telomerase-immortalized human corneal epithelial cells (HCLE).

125 We derived immortalized human DPC lines from balding (BAB) and non-

126 itro model for UVB-induced skin cancer using immortalized human epidermal keratinocyte (HaCaT) cells

127 Further analysis of UBTF1/2 DNA binding in immortalized human epithelial cells and their isogenical

128 A workflow was established using telomerase-immortalized human epithelial cells that revealed highly

129 miR-155-5p expression was also observed when immortalized human fetal airway epithelial (FeAE) cells

130 ls of the microenvironment using primary and immortalized human fibroblasts from normal ovary and tum

131 ypersensitivity to oxidative stress in hTERT-immortalized human foreskin fibroblasts (HFF-hTERT).

132 nse of pocket epithelium-derived, telomerase-immortalized human gingival keratinocytes (TIGKs) to mic

133 We used conditionally immortalized human glomerular endothelial cells (GEnCs),

134 Primary or immortalized human hepatic stellate (LX2) cells were exp

135 epatocellular carcinoma (HepG2) cell line or immortalized human hepatocytes (IHH) and activation of i

136 r Ab-dependent cell-mediated cytotoxicity of immortalized human hepatocytes in the presence of CD55-b

137 CV-infected hepatoma cells (Huh7.5 cells) or immortalized human hepatocytes inhibited C3 convertase a

138 Hepatoma cell line and immortalized human hepatocytes transiently transfected o

139 TRPV3 channels endogenously expressed in an immortalized human keratinocyte cell line (HaCaT) and in

140 Incubation of primary or immortalized human keratinocytes with Leishmania infantu

141 the stem cell renewal factor beta-catenin in immortalized human mammary epithelial and carcinoma cell

142 there have been contradictory reports on an immortalized human mammary epithelial cell line (HMLE) t

143 omotes breast cancer initiation in models of immortalized human mammary epithelial cells (HMECs).

144 acting upstream to induce EMT in normal and immortalized human mammary epithelial cells in an appare

145 xpression promotes tumorigenic phenotypes in immortalized human mammary epithelial MCF10A cells and,

146 DESIGN, SETTING, AND MATERIAL: Immortalized human meibomian gland epithelial cells were

147 found that compared with normal primary and immortalized human melanocytes, SIRT3 is significantly o

148 Immortalized human mesothelial cells and primary mesothe

149 Using immortalized human myoblasts with a titratable DUX4 tran

150 Using immortalized human myoblasts, we performed RNA-seq analy

151 Using immortalized human myometrial (hTERT-HM) cells stably ex

152 blastoma multiforme (GBM) model derived from immortalized human neural stem/progenitor cells (hNSCs)

153 Rac exchange factor 2 (PREX2) using the same immortalized human NRAS(G12D) melanocytes as the origina

154 man oral keratinocytes (NHOKs) and papilloma-immortalized human oral keratinocyte (HOK16B) cells, we

155 n a panel of ovarian cancer cells but not in immortalized human ovarian surface epithelial cells.

156 In this study, we utilized immortalized human pancreatic CAFs to investigate molecu

157 Expression of P5P6 in immortalized human pancreatic duct epithelial (HPDE) cel

158 Overexpression of R431C mutant ANLN in immortalized human podocytes results in enhanced podocyt

159 -based metabolite profiling was performed on immortalized human prostate epithelial cells transformed

160 on for Schwann cell transformation in vitro (immortalized human Schwann cells) and MPNST formation in

161 Next, immortalized human T cells (Jurkats) expressing a functi

162 nt to provide IL-2-independent growth of Tax-immortalized human T cells and increase the tumor format

163 s from wild-type and Elf3 knockout mice, and immortalized human T/C-28a2 and murine ATDC5 cell lines

164 TRPV4 to the plasma membrane of primary and immortalized human TM (hTM) cells, and to human and mous

165 KSHV replication, we xeno-grafted telomerase-immortalized human umbilical vein endothelial cells that

166 AE immortalizes human CD34(+) cord blood cells in long-term

167 xpression in human umbilical cord, HUVECs or immortalized HUVECs (HUV-ST).

168 n umbilical vein endothelial cells and their immortalized hybridoma line, EA.hy926.

169 The transposon-tagged lines have been immortalized in seed stocks and can be accessed through

170 terovirus 71 (EV71), and that contrary to an immortalized intestinal cell line, enteroids induced ant

171 In the first model, an immortalized keratinocyte cell line (NIKS) was used, in

172 tastatic melanoma cell line (SKMEL- 147) and immortalized keratinocyte cells (HaCaT).

173 expression and DNA methylation using normal immortalized keratinocyte lines, NIKS, NIKS-16, NIKS-18,

174 ed cell populations of normal, spontaneously immortalized keratinocytes (NIKS) and NIKS stably transf

175 Immortalized keratinocytes (p.Ile482Lys) showed altered

176 , rare cells positive for Lgr6 expression in immortalized keratinocytes and show that their frequency

177 tiviral restriction activity was observed in immortalized keratinocytes transfected with the religate

178 y genes that are regulated by alpha3beta1 in immortalized keratinocytes.

179 netheless, hTERT-W930F, but not hTERT-V791Y, immortalizes limited-lifespan human cells.

180 Observations were confirmed in an immortalized line (BEAS-2B) by QRT-PCR and protein assay

181 umors and other solid tumors, and also in an immortalized line of human CAFs.

182 Telomerase-immortalized lines of control and R258C human dermal fib

183 Primary human LSECs (HLSECs) and immortalized liver endothelial cells (TMNK-1) were expos

184 e in multiple lung cell lines, including the immortalized lung cell BEAS-2B.

185 vels modulate KRAS-induced transformation of immortalized lung epithelial cells.

186 Using EBV-immortalized lymphoblastoid cell lines (LCLs) as a model

187 man cancers and transform B lymphocytes into immortalized lymphoblastoid cell lines in vitro.

188 were increased in proband versus control EBV-immortalized lymphoblastoid cell lines.

189 neutralization by the 72A1 MAb, efficiently immortalized macaque B cells in vitro, and successfully

190 ected in the membrane-containing fraction of immortalized macrophages after caspase-11 activation by

191 Using immortalized macrophages, we validate the ubiquitin prot

192 Cai levels were significantly higher in immortalized malignant hyperthermia-susceptible B cells

193 noclonal antibodies (mAbs) manufactured from immortalized mammalian cell lines are becoming increasin

194 Depleting HOXA5 in immortalized MCF10A or transformed MCF10A-Kras cells red

195 mor-suppressor protein to the perinucleus in immortalized MEF cells is correlated with the translocat

196 use human pluripotent stem cells to generate immortalized megakaryocyte progenitor cell lines that ca

197 otential of Hs294T melanoma cells and normal immortalized Mel-ST melanocytes.

198 PARP1 also transformed TERT-immortalized melanocytes expressing BRAF(V600E).

199 and tracked DAT's postendocytic itinerary in immortalized mesencephalic cells.

200 iopsies (n = 13), and primary peritoneal and immortalized mesothelial cells (MeT5A) by immunohistoche

201 zed with EBV gp350 is capable of efficiently immortalizing monkey B cells in vitro and reproduces acu

202 xpression, and adhesion of human primary and immortalized monocytes (Mono Mac 6) were measured.

203 fer NAI resistance in avian viruses grown in immortalized monolayer cells, especially those of the N3

204 We report that overexpression of HSPB8 in immortalized motor neurones decreased the accumulation o

205 the compounds showed negligible toxicity in immortalized mouse cortical neurons Neuro2A and primary

206 rt explants, adult rat epicardial cells, and immortalized mouse embryonic epicardial cells as model s

207 ogene-induced transformation using G0s2-null immortalized mouse embryonic fibroblasts (MEF).

208 s major defects in cell cycle progression in immortalized mouse embryonic fibroblasts (MEFs) from PIN

209 ces SMAD1/5/8 phosphorylation in a subset of immortalized mouse endothelial cell lines, but not in pr

210 and modulate in vitro cellular rhythms in an immortalized mouse fibroblast line (NIH 3T3).

211 We have found that in an immortalized mouse hepatocyte cell line in which efficie

212 We report here that in an immortalized mouse hepatocyte cell line, AML12HBV10, in

213 ethanol-induced lipophagy was studied in an immortalized mouse hepatocyte line, AML12.

214 e autophagy in osteosarcoma U-2 OS cells and immortalized mouse hippocampal HT22 cells, characterized

215 describe a genome-wide CRISPR/Cas9 screen in immortalized mouse macrophages aiming at the unbiased id

216 enriched in mouse Schwann cells compared to immortalized mouse motor neurons (MN-1), and is predicte

217 d a decrease in Synpo mRNA and protein in an immortalized mouse podocyte cell line.

218 Pkm-knockdown immortalized mouse podocytes had higher levels of toxic

219 In immortalized mouse podocytes, JAK2 knockdown decreased T

220 DHPS or DOHH induced tolerance to anoxia in immortalized mouse renal proximal cells.

221 of a GFP-based NF-kappaB reporter system in immortalized murine bone marrow-derived macrophages (iBM

222 Immortalized murine cementoblasts (OCCM.30), similar to

223 e chromosomes 9, 10, 12, or 14 in tetraploid immortalized murine embryonic fibroblasts.

224 aracterized an in vitro system of transduced immortalized murine macrophages expressing either WT or

225 Hsp90 inhibitor, on LPS-induced response in immortalized murine macrophages.

226 to F. novicida infection in both primary and immortalized murine macrophages.

227 Here, we developed immortalized murine myoblast cell lines to examine the p

228 blasts but is downregulated by H-Ras(V12) in immortalized NIH 3T3 cells through a mechanism involving

229 the AGS and MKN1 gastric cancer and HFE-145 immortalized non-neoplastic gastric mucosa cell lines.

230 Using the immortalized non-tumorigenic human ovarian surface epith

231 We developed an in vivo assay based on the immortalized nontumorigenic breast cell line MCF10A and

232 ncer cells and BPH-1 cells but not in RWPE-1 immortalized nontumorigenic prostate epithelial cells or

233 strate that nicotine up-regulates NeuroD1 in immortalized normal bronchial epithelial cells and a sub

234 down in ESCC cell lines (KYSE450 and T.Tn), immortalized normal esophageal epithelial cell lines (NE

235 In immortalized normal human astrocytes (NHAs) and syngenei

236 ate that PML depletion in U2OS cells or TERT-immortalized normal human diploid fibroblasts results in

237 an papillomavirus 16 (HPV 16) E6 and E7 gene-immortalized normal human epidermal keratinocytes, we de

238 man telomerase reverse transcriptase (hTERT)-immortalized normal human urothelial (NHU) and bladder c

239 pot and UC-specific rare PIK3CA mutations in immortalized normal human urothelial cells (NHUC) and mo

240 Expression of the fusions in immortalized normal human urothelial cells (NHUC) induce

241 cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells.

242 er methylation in an EBV-infected telomerase-immortalized normal oral keratinocyte (NOKs) cell line w

243 When immortalized normal prostate 267B1 cells were transfecte

244 owever, no effect was observed in the RWPE-1-immortalized normal prostate epithelial cells.

245 arian cancer cell lines relative to those in immortalized normal surface epithelial cells and that su

246 ar subtypes of breast cancer, as well as two immortalized ("normal") human breast cell lines.

247 has little effect on virus growth in either immortalized or primary monkey kidney cells.

248 ssion programs that control the behaviors of immortalized or transformed keratinocytes remain underex

249 shed to map epigenetic changes in telomerase-immortalized oral keratinocytes.

250 ntly amplified gene that potently transforms immortalized ovarian and fallopian tube secretory epithe

251 26 ovarian cancer cell lines, HGSOC tumours, immortalized ovarian surface epithelial cells and fallop

252 milar phenotype and destroyed autologous and immortalized ovarian tumor cells, following earlier puls

253 Immortalized patient B cells displayed impaired IkappaBa

254 A detailed analysis of immortalized patient-derived B cells that contained vari

255 ation 873 EFO-CLO aligned and 344 EFO unique immortalized permanent cell lines.

256 sibility of inactivating PERV activity in an immortalized pig cell line.

257 ultured myotubes differentiated ex vivo from immortalized plectin-deficient myoblasts revealed them t

258 Here, we established an immortalized polyclonal human parietal epithelial cell (

259 and chromatin opening during adipogenesis of immortalized preadipocytes derived from mouse brown adip

260 EBVDeltaCTCF166 virus-immortalized primary B lymphocytes showed a decrease in

261 most cancers are carcinomas, we selected an immortalized primary baby mouse kidney (iBMK) cell model

262 c histone acetylation levels, as well as for immortalizing primary cells.

263 tent of NER in diverse cell types, including immortalized, primary and stem-like cells.

264 Introduction of FOXA1 and HOXB13 into an immortalized prostate cell line reprogrammed the AR cist

265 anced expression of YAP is able to transform immortalized prostate epithelial cells and promote migra

266 at hypoxia induces F77 epitope expression in immortalized prostate RWPE1 cells, which express F77 ant

267 ssue recombination studies in nude mice with immortalized prostatic epithelial cells expressing IL-1a

268 in directly suppresses 1alpha-hydroxylase in immortalized proximal tubular cells.

269 Here, we utilized primary and immortalized PSC obtained from mice and patients with CP

270 Exposure of immortalized PT cell lines to physiologically relevant l

271 Expression of exogenous PrP(C) in immortalized PT cells showed localization on the plasma

272 Immortalized rat renal proximal tubular cells (IRPTCs) a

273 that displays strong regulatory activity in immortalized rat Schwann (S16) cells.

274 Compared with wild-type cells, PC1-depleted immortalized renal collecting duct cells had higher leve

275 is in human telomerase reverse transcriptase immortalized retinal pigmented epithelial and mouse inne

276 Human IgG/M binding to primary RMEC, immortalized RMEC (iRMEC), and iRMEC-deficient in B4GALN

277 -stimulated cell transformation of the HaCaT immortalized skin cell line and mutation of NFAT3 at Ser

278 Both primary and immortalized Spag6-deficient MEFs proliferated at a much

279 system of gastric organoids co-cultured with immortalized stomach mesenchymal cells (ISMCs).

280 Activity of WNT in media collected from immortalized stomach mesenchymal cells correlated with i

281 Organoids maintained in co-culture with immortalized stomach mesenchymal cells express robust nu

282 In gastric organoids cocultured with immortalized stomach mesenchymal cells, antagonists of W

283 thened (vismodegib) and then cocultured with immortalized stomach mesenchymal cells, to assess prolif

284 tion and invasion compared to commonly used, immortalized TB cell lines and primary cells from term p

285 elect for stabilizing mutations in p53 that "immortalize" the cultures and that, after serial passage

286 Although immortalized, these cells nonetheless retain normal grow

287 Human mammary epithelial cells immortalized through TERT expression and human carcinoma

288 DC) mice shortened over the generations, and immortalized TIN2(+/DC) mouse embryonic fibroblasts (MEF

289 ctivation does not cooperate with MLL-AF4 to immortalize/transform hESC-derived hematopoietic cells,

290 onstrate a prominent role for alpha3beta1 in immortalized/transformed keratinocytes in regulating fib

291 lines based on Cre-mediated excision of the immortalizing transgenes.

292 uPA expression in TSC2-null tumor cells and immortalized TSC2-null angiomyolipoma cells, but not in

293 We propose that in an immortalized ("undead") model of AiP, signaling back and

294 ntroduced wild-type (WT) or mutant IDH1 into immortalized, untransformed human astrocytes, then monit

295 ntigen deletions were cultured in cell lines immortalized using simian virus 40 (SV40) T antigen, sug

296 s [PBMCs], CD14(+) monocytes, and telomerase-immortalized vascular endothelial [TIVE] cells), from vi

297 blastoma cell proliferation, including cells immortalized via the telomerase-independent ALT mechanis

298 In culture, GR-deficient primary or immortalized white and brown preadipocytes showed severe

299 use haematopoietic stem and progenitor cells immortalized with the fusion protein MLL-AF9 to generate

300 Conditionally immortalized, young adult mouse colonic (YAMC) epithelia