ライフサイエンスコーパス: immortalized cell

1 cancer and how it promotes transformation in immortalized cells.

2 ctively in cancer cells and not in normal or immortalized cells.

3 reased in response to UVB in HFK, but not in immortalized cells.

4 sion was upregulated in primary HFK, but not immortalized cells.

5 pression was significantly increased only in immortalized cells.

6 as shown to induce tumorigenic phenotypes in immortalized cells.

7 redominantly localized in the nucleus in the immortalized cells.

8 ells but is present in cancerous tissues and immortalized cells.

9 with the same efficiency in normal and hTERT-immortalized cells.

10 nts, ZNF217-transduced cultures gave rise to immortalized cells.

11 d EGFR levels comparable with those of E6/E7-immortalized cells.

12 er genomic instability, such as malignant or immortalized cells.

13 ivity upon an endogenous target gene only in immortalized cells.

14 f endogenous target genes both in mortal and immortalized cells.

15 icts previous experiments using trypsinized, immortalized cells.

16 gthening of telomeres in telomerase-negative immortalized cells.

17 t induction of apoptosis in both primary and immortalized cells.

18 f CSF-1 was found to induce apoptosis in the immortalized cells.

19 nd differentiation potential, or have become immortalized cells.

20 at are T-cell-immunodeficient can reject EBV-immortalized cells.

21 P-1 and NF-kappaB transactivation in the HPV-immortalized cells.

22 ion, and tested them in primary cultured and immortalized cells.

23 ivated in the majority of cancer tissues and immortalized cells.

24 7), characteristically expressed on in vitro-immortalized cells.

25 ed in normal somatic cells but is present in immortalized cells.

26 the levels of hTR in primary, precrisis, and immortalized cells.

27 al AAV serotypes and a number of primary and immortalized cells.

28 erase activity were observed in the parental immortalized cells.

29 ting that this phenomenon is not specific to immortalized cells.

30 was maintained and could activate ERK1/2 in immortalized cells.

31 c defects that we observe are not evident in immortalized cells.

32 ts in normal cells but it is disconnected in immortalized cells.

33 proliferation of normal cells but transforms immortalized cells.

34 duced apoptotic and proliferation changes in immortalized cells.

35 by alpha3beta1 and TGFbeta is a property of immortalized cells.

36 apoptosis in cancer cells, but not in normal/immortalized cells.

37 terns, and expression of hTERT in cancer and immortalized cells.

38 ry keratinocytes, Id3 is upregulated only in immortalized cells.

39 Notably, unlike immortalized cells, all treated cell populations eventua

40 Immortalized cells also expressed SV40 large T antigen.

41 nuous expression of cooperating oncogenes in immortalized cells, although essential for anchorage-ind

42 nit of telomerase, which is highly active in immortalized cells and >85% of human cancers but is quie

43 on of ITPR1 induced TDP-43 nuclear export in immortalized cells and primary neurons and strongly pote

44 used to transfer mtDNA into rapidly dividing immortalized cells and, thereby, respiratory-deficient t

45 ucible gene in glial-derived cells including immortalized cells, and appears to be transcriptionally

46 etbp1-immortalized cells compared with other immortalized cells, and are induced shortly after Setbp1

47 shly prepared primary cells, isogenic cells, immortalized cells, and cancer cell lines.

48 models tested (e.g., between primary cells, immortalized cells, and in cocultures of immortalized hu

49 ansposition in up to 91% of actively growing immortalized cells, and we demonstrated that L1 retrotra

50 cultured keratinocytes, while expression by immortalized cells appears to be independent of the exog

51 ositive cytokeratin staining showed that the immortalized cells are keratinocytes; cell surface level

52 se results support a model in which HPV16 E7-immortalized cells are primed to undergo apoptosis, give

53 This analysis revealed that common immortalized cells are related to adult muscle precursor

54 We have immortalized cells at several stages along this pathway

55 (BCL-2) to early-infected (MCL-1/BCL-2) and immortalized cells (BFL-1).

56 ration of many cell types, primary cells and immortalized cells, by inducing a G1 arrest.

57 sent at dramatically higher levels in Setbp1-immortalized cells compared with other immortalized cell

58 2 phosphorylation was observed in c-Myc from immortalized cells compared with primary cells.

59 Immortalized cells contained structurally intact HRX-ENL

60 Surprisingly, as the resulting immortalized cells containing active telomerase continue

61 o three passages of CVB3 in primary, but not immortalized, cell cultures.

62 er, rhythms of peripheral tissue explants or immortalized cells damp partially or completely.

63 s rhythmicity to other cells was compared in immortalized cells derived from the suprachiasmatic nucl

64 RPKD nephrectomy specimens and conditionally immortalized cells derived from these cysts.

65 The immortalized cells differentiate efficiently into mature

66 More importantly, the immortalized cells displayed characteristics typical of

67 The hTERT-immortalized cells divided in basic fibroblast growth fa

68 Suppression of either gene in Setbp1-immortalized cells drastically reduces their colony-form

69 cells is smaller than that produced in other immortalized cells due to cleavage.

70 The metabolic support provided by the immortalized cells equaled that observed after transplan

71 These immortalized cells exhibited "prostaspheres" in nonadher

72 Immortalized cells exhibited a CD4(+)CD25(+)CD3(-) pheno

73 rganotypic raft cultures, however, the hTERT-immortalized cells exhibited a maturation delay on termi

74 These immortalized cells exhibited low p53 levels at late pass

75 Moreover, the immortalized cells exhibited no oncogenicity, and no up-

76 ever, the DHS compartment in pluripotent and immortalized cells exhibits higher mutation rates than t

77 Variable proportions of immortalized cells expressed B7-1/B7-2 molecules and FAS

78 to E6 + E7-immortalized cells, the Myc + E7-immortalized cells expressed high levels of p53 protein

79 Immortalized cells expressed stem cell markers that incl

80 Finally, combinatorial screenings on immortalized cells followed by in vivo targeting establi

81 s of the biosynthetic pathways in cloned EBV-immortalized cells from patients with IgA nephropathy in

82 As controls, we showed that EBV-immortalized cells from patients with lupus nephritis an

83 The immortalized cells had a signature comparable to MDV-tra

84 These immortalized cells have a decreased capacity to differen

85 tably, similar to parental normal cells, Rho-immortalized cells have WT p53 and intact G(1) cell cycl

86 roduction of HRAS(V12) or KRAS(V12) into the immortalized cells, however, allowed them to form s.c. t

87 f transposon insertion sites from tumors and immortalized cells identified more than 200 frequently m

88 e for the antitumor response elicited by EBV-immortalized cells in athymic mice.

89 her demonstrate the usefulness of telomerase-immortalized cells in studying this cellular phenotype.

90 Although the potential use of telomerase-immortalized cells in the clinic remains controversial,

91 In addition, in contrast to drug-treated, immortalized cells in vitro, mature motor neurons rarely

92 Patient-derived cells as well as immortalized cells in which PARN is disrupted show decre

93 Overexpression of c-Myc in immortalized cells increases cell proliferation, inhibit

94 Adenoviral transduction of hCLCA2 into immortalized cells induces p53, CDK inhibitors p21 and p

95 ely active NFATc1 mutant (caNFATc1) in these immortalized cells inhibits their differentiation into m

96 dylinositol 3-kinase/PKB pathway, whereas in immortalized cells, insulin-stimulated phosphorylation w

97 cerns associated with the transplantation of immortalized cells into human patients.

98 the improper dependency of H3K27me3 by mC in immortalized cells is likely to be fundamental to cancer

99 ata have shown that DNA repair in telomerase-immortalized cells is normal.

100 d cells and required for the survival of EBV-immortalized cells, lead to a number of studies demonstr

101 pid initiation of this checkpoint both in an immortalized cell line (mIMCD3) and in second-passage IM

102 ed from supernatant of an Epstein-Barr virus-immortalized cell line and identified as fragments of ca

103 AT(4) receptor in epithelial HK-2 cells (an immortalized cell line derived from adult human proximal

104 to rodent models, we explored the use of an immortalized cell line derived from human dorsal root ga

105 mor-tropic properties of HB1.F3.C1 cells, an immortalized cell line derived from human fetal telencep

106 Here, we use Oli-neu cells, an immortalized cell line derived from primary murine oligo

107 nd other reasons, we created a conditionally immortalized cell line derived from the OSN lineage, whi

108 Lysate proteins from an immortalized cell line from a MMTV-neu mouse model and f

109 rowth factor (bFGF), we used a conditionally immortalized cell line from rat hippocampal neurons (H19

110 iation, we have investigated a conditionally immortalized cell line from rat hippocampal neurons (H19

111 ng on the neural crest, we have generated an immortalized cell line from young Hensen's node.

112 of either normal human keratinocytes or the immortalized cell line HaCaT.

113 Expression in the immortalized cell line HC11 correlated with slow or arre

114 , and PC-3 cell lines, HEK293 cells, the EBV-immortalized cell line IB4, and the Burkitt's lymphoma c

115 Furthermore, inducing OPN expression in an immortalized cell line increased cell proliferation.

116 An immortalized cell line obtained from human retina was in

117 ization of Na+-dependent GSH transport in an immortalized cell line of human cerebrovascular endothel

118 resident immune cells of the brain, and the immortalized cell line of human microglia-SV40.

119 An immortalized cell line representing the primitive erythr

120 The conditionally immortalized cell line should prove useful in identifyin

121 The aim of this study was to obtain an immortalized cell line that exhibits characteristics of

122 -conditioned medium (BSN-CM) derived from an immortalized cell line thought to originate in the early

123 s and human dermal microvascular endothelial immortalized cell line to delineate the cellular signali

124 ChR) expressed in hair cell precursors in an immortalized cell line UB/OC-2 developed from the organ

125 mal somatic tissues, placenta, sperm, and an immortalized cell line, a visualization tool that has be

126 studies in UB/OC-1 cells, an organ of Corti immortalized cell line, showed that R-PIA reduced cispla

127 th factors rapidly induced PKD activation in immortalized cell lines (e.g. Swiss 3T3 and Rat-1 cells)

128 production in two estrogen-responsive, human immortalized cell lines (hFOB/ER3 and hFOB/ER9) that dis

129 B cells in vitro results in establishment of immortalized cell lines (lymphoblastoid cell lines (LCL)

130 transformation has been shown in vitro with immortalized cell lines and in vivo using retroviral tra

131 NA is expressed in several human tissues and immortalized cell lines and is only expressed during the

132 sosomal phenotypes and cell toxicity in both immortalized cell lines and neurons.

133 ectious B. burgdorferi strain N40 to several immortalized cell lines and primary cultured cells, incl

134 (2) the multiplexed, on-chip sorting of both immortalized cell lines and primary immune cells with an

135 -based ontology that contains information of immortalized cell lines and relevant experimental compon

136 ction of hsp70 gene expression have utilized immortalized cell lines and temperatures above the physi

137 ssues, but is upregulated in the majority of immortalized cell lines and tumors.

138 These immortalized cell lines are capable of maintaining HPV-3

139 These immortalized cell lines are highly proliferative and the

140 orly understood, in part because appropriate immortalized cell lines are not available.

141 iteria for selecting study subjects for whom immortalized cell lines are preferable to merely extract

142 ficantly higher levels of CpG methylation in immortalized cell lines as compared to primary murine fi

143 nolayers indicated that AP activated ENaC in immortalized cell lines as well as post-transplant, prim

144 Ectopically expressed NLRP2 in immortalized cell lines assembles an inflammasome and in

145 hiPSC-CMs may be advantageous over immortalized cell lines because they possess similar fun

146 ce to primary bronchial epithelial cells and immortalized cell lines by up-regulating eukaryotic cell

147 more, our results raise the possibility that immortalized cell lines can be used for replacement of s

148 h-regulatory genes by de novo methylation in immortalized cell lines could be reversed, possibly rest

149 n OLs cultured from jp and normal CNS and in immortalized cell lines derived from jp and normal OLs.

150 ne receptor adhesion-related kinase (Ark) in immortalized cell lines derived from migratory but not p

151 Two immortalized cell lines derived from the day 11.5 embryo

152 f AAV vectors and adenovirus (Ad) vectors in immortalized cell lines from CF patients and in nasal ep

153 The BCL-6 immortalized cell lines had a phenotype consistent with

154 The CD133(+) cells from these immortalized cell lines had high proliferative potential

155 To address these issues, immortalized cell lines have been generated.

156 ndary recipients and could be established as immortalized cell lines in liquid cultures.

157 ent replication in primary cells and certain immortalized cell lines in vitro and, in all likelihood,

158 pacity and could be readily established into immortalized cell lines in vitro.

159 ansforming primary human CD4(+) T cells into immortalized cell lines indistinguishable from patient-d

160 icroarray expression data sets obtained from immortalized cell lines of the individuals represented i

161 er current industry standard assays that use immortalized cell lines or animal models.

162 Several immortalized cell lines serve as models for procholecyst

163 CPR can be used not only with immortalized cell lines such as fibroblasts and Jurkat T

164 -infected p53-deficient B cells gave rise to immortalized cell lines that could be maintained by CD40

165 itions by using dominant mutants of Cdc42 in immortalized cell lines that may introduce nonspecific e

166 y of genetic diseases such as cancer and for immortalized cell lines that might be used in research a

167 kinases (IKK-1 and IKK-2) were identified in immortalized cell lines that regulate NF-kappa B activat

168 logical assays that have been performed with immortalized cell lines to be applied to spheroids.

169 f RhoA signaling function is from studies in immortalized cell lines utilizing inhibitors or dominant

170 A panel of immortalized cell lines was challenged with the RAD51-st

171 Several immortalized cell lines were established from the livers

172 The primary line and the telomerase-immortalized cell lines were treated with either ultravi

173 ng (ChIP-seq) analyses have focused on a few immortalized cell lines whose activities and physiology

174 A screen of human tissues and immortalized cell lines with this antibody reveals AIPL1

175 The availability of a model with immortalized cell lines would remove the considerable ba

176 Two independent HPV16 E6-immortalized cell lines, alphaE6#1 and alphaE6#2, that s

177 In contrast, two independent HPV16 E7-immortalized cell lines, alphaE7#1 and alphaE7#2, both o

178 ads from 46 primary cell types, 42 cancer or immortalized cell lines, and 26 tissues.

179 HRV-C cannot be propagated in immortalized cell lines, and currently sinus organ cultu

180 s including porcine fetal cells, stem cells, immortalized cell lines, and marrow stromal cells are un

181 to exhibit significant promoter activity in immortalized cell lines, and these elements could intera

182 pathways were conducted using established or immortalized cell lines, and when HBx was expressed in t

183 l human ovarian surface epithelial cells and immortalized cell lines, four of the seven ovarian carci

184 cell culture tools, including primary cells, immortalized cell lines, human stem cells, and their mor

185 In contrast to immortalized cell lines, in NHBEs strong retinoid-induce

186 o assist endocytic exit, which works well on immortalized cell lines, was of little value because of

187 s enhanced bacterial adhesion to primary and immortalized cell lines.

188 wth suppressive effects on normal primary or immortalized cell lines.

189 for association with the FcR gamma-chain in immortalized cell lines.

190 ompetent primary sheep endothelial cells and immortalized cell lines.

191 anel of human and nonhuman primary cells and immortalized cell lines.

192 to phorbol ester-treated cells or a panel of immortalized cell lines.

193 , B cells infected by the virus readily form immortalized cell lines.

194 that control cellular growth and to generate immortalized cell lines.

195 utilizing both primary cells and established immortalized cell lines.

196 factors are required for postentry events in immortalized cell lines.

197 ial agents when delivering genes to multiple immortalized cell lines.

198 otprints is not an artifact of commonly used immortalized cell lines.

199 pecies induce cytoskeletal reorganization in immortalized cell lines.

200 te lines compared to the less progressed but immortalized cell lines.

201 DNA directly from white blood cells or from immortalized cell lines.

202 l human mammary epithelial cells and benign, immortalized cell lines.

203 A knockdown was employed in human normal and immortalized cell lines.

204 HDR studies have focused on transformed and immortalized cell lines.

205 ition characteristic of fibroblasts and many immortalized cell lines.

206 atic tissues, and particularly so in various immortalized cell lines.

207 h were recurrently affected in the set of 25 immortalized cell lines.

208 termine cell polarity in lower eukaryotic or immortalized cells, little is known about the transcript

209 Immortalized cells maintain telomere length through eith

210 omere dysfunction and segregation defects in immortalized cells maintaining telomeres by either the a

211 Interestingly, this transgene also immortalized cells of the thyrotrope lineage that expres

212 Immortalized cells or enriched primary hematopoietic ste

213 rmalities, whereas populations of cdk4/hTERT-immortalized cells or hTERT-immortalized cells that had

214 or because cells with a disrupted (EGFR(-/-) immortalized cells) or neutralized (EGFR blocking antibo

215 the selection of rare, spontaneously arising immortalized cells, or the use of an entire viral genome

216 Late-passage immortalized cells (passage 30) showed a 25-fold increas

217 The cloned immortalized cells proliferate in culture at 33 degrees

218 Knockdown of E2 in immortalized cells reestablishes in a reversible manner

219 Remarkably, the immortalized cells retained the capacity for myogenic di

220 More importantly, these immortalized cells showed anchorage-independent growth a

221 However, Tax-immortalized cells stay dependent on IL-2, suggesting th

222 t 100-fold more selective for AML than solid immortalized cells such as HEK293 or human peripheral bl

223 Herein, a non-transformed, immortalized cell system was used to investigate the eff

224 ine inhibits growth in a non-transformed/non-immortalized cell system, possibly through an elevation

225 In human tumors and immortalized cells, telomeres are often maintained at a

226 r CD133 expression was detected in the hTERT-immortalized cells than in primary prostate cells.

227 All three types [EBV-immortalized cells that express a broad spectrum of the

228 ns of cdk4/hTERT-immortalized cells or hTERT-immortalized cells that had lost expression of p16INK4A

229 ed cells and ovarian cancer cells but not in immortalized cells that had not been transformed.

230 tosis but ultimately selecting for surviving immortalized cells that have sustained either p53 mutati

231 promyelocytic leukemia nuclear body found in immortalized cells that maintain telomeres in a telomera

232 In contrast to E6 + E7-immortalized cells, the Myc + E7-immortalized cells expr

233 In tumours and immortalized cells, this decline is halted through the a

234 he precisely opposite response of normal and immortalized cells to constitutive activation of the MAP

235 rocell-mediated transfer of chromosomes into immortalized cells to identify putative senescence-induc

236 e likely to contribute to the ability of EBV-immortalized cells to modulate immune responses, adhesio

237 surmise that additional genes are altered in immortalized cells to suppress the apoptotic pathway and

238 of PTX and Cs(+) were also observed in GH(3) immortalized cells transiently expressing ET(A) receptor

239 expression of these mutants failed to render immortalized cells tumorigenic, partial suppression of e

240 Compared with immortalized cells, tumorigenic cells had greater activa

241 e 1% of the human genome in both primary and immortalized cell types.

242 ata has revealed that while both primary and immortalized cells undergo growth arrest in suspension,

243 elomere structural proteins TRF1 and TRF2 in immortalized cells using the alternative lengthening of

244 roportion of the p53 protein in the Myc + E7-immortalized cells was localized to the cytoplasm, poten

245 Rho-immortalized cells were anchorage dependent and were una

246 from all three genotypes were the same, and immortalized cells were obtained from all cell cultures

247 orescence microscopy studies showed that the immortalized cells were phenotypically similar and respo

248 , HVS deltaSTP/c-ras- and HVS deltaSTP/v-ras-immortalized cells were principally CD4+ CD8+ double-pos

249 Both normal and immortalized cells were resistant to TRAIL-induced apopt

250 Immortalized cells were unable to induce leukemias after

251 established as a potent hCAR deactivator in immortalized cells; whether it inhibits hCAR activity un

252 y inactive, high molecular mass complexes in immortalized cells, which are converted into enzymatical

253 s shown to induce and maintain conditionally immortalized cells, which was accompanied by increased t

254 ility complex (MHC) was expressed by >97% of immortalized cells, while class II MHC and intercellular

255 sulting in the long run in the appearance of immortalized cells with high proliferative activity.