ライフサイエンスコーパス: immune evasion

1 e involvement of complex viral mechanisms of immune evasion.

2 l a metabolic target and mechanism of cancer immune evasion.

3 microenvironment to promote oncogenesis and immune evasion.

4 he parasite's genome and plays a key role in immune evasion.

5 olecule provided a direct mechanism of tumor immune evasion.

6 g and developing novel targets against tumor immune evasion.

7 t easily adaptable to sequence diversity and immune evasion.

8 ntify a previously unknown viral strategy of immune evasion.

9 role of bacterial metabolism in host innate immune evasion.

10 vailability of peptides for presentation and immune evasion.

11 s, an essential step for tissue invasion and immune evasion.

12 evolutionary dynamics and sites of selective immune evasion.

13 c neoantigens that are unmasked during tumor immune evasion.

14 erstanding RCA disease-related mutations and immune evasion.

15 cluding growth factor receptor signaling and immune evasion.

16 leukocyte antigen (HLA) loss may facilitate immune evasion.

17 sistence by increasing bacterial fitness and immune evasion.

18 ns are important for viral pathogenicity and immune evasion.

19 yse human phagocytic cells and contribute to immune evasion.

20 s phosphorylation event mediates US3-induced immune evasion.

21 ost receptors while also diversifying to aid immune evasion.

22 n, which may lead to antigenic variation and immune evasion.

23 al adhesion kinase (FAK) promotes anti-tumor immune evasion.

24 estigate the mechanism of action of Pfs47 on immune evasion.

25 mmune cells to these tumors, which may allow immune evasion.

26 are known to play important roles in tumour immune evasion.

27 lection of CovRS mutations and in GAS innate immune evasion.

28 significant roles in host cell invasion and immune evasion.

29 mechanisms involved in host defense or viral immune evasion.

30 evolution, including amino acid changes and immune evasion.

31 ) are required for full effectiveness of the immune evasion.

32 virus entry, replication, morphogenesis, and immune evasion.

33 on, G-F interactions, G oligomerization, and immune evasion.

34 maintain self-tolerance and to promote tumor immune evasion.

35 lance between the host immune system and EBV immune evasion.

36 alance between host immune responses and EBV immune evasion.

37 fied exosomes contribute to virus spread and immune evasion.

38 n maintaining bloodstream stage identity and immune evasion.

39 retion of TGF-beta is a potent mechanism for immune evasion.

40 y molecule and add antigens that block HSV-2 immune evasion.

41 ch encodes a lipid A deacylase important for immune evasion.

42 ion and emphasizes cording as a mechanism of immune evasion.

43 id (HA) capsule that plays critical roles in immune evasion.

44 esses numerous virulence factors that aid in immune evasion.

45 subunit vaccine that attempts to block HSV-2 immune evasion.

46 advances our understanding of KSHV-mediated immune evasion.

47 is implicated in Ebola virus cell entry and immune evasion.

48 ein, and thereby define a novel mechanism of immune evasion.

49 cells, and describe a new mechanism of virus immune evasion.

50 of M. genitalium infection, persistence, and immune evasion.

51 two critical effectors involved in bacterial immune evasion.

52 ent and induce PD-1 signaling and associated immune evasion.

53 nduce tumor cell apoptosis or decrease tumor immune evasion.

54 repurposed for multiple functions, including immune evasion.

55 nces between them in polymerase function and immune evasion.

56 ges in receptor usage and thereby to lead to immune evasion.

57 nses, providing a mechanism that may promote immune evasion.

58 n both domains that partially contributed to immune evasion.

59 hence their likely primary role is enabling immune evasion.

60 dictates the fate of ingested DNA in DCs for immune evasion.

61 glec-7 ligands to interfere with cancer cell immune evasion.

62 orB interactions contribute to host adaptive immune evasion.

63 s an essential role in viral replication and immune evasion.

64 sponses by M. tuberculosis may contribute to immune evasion.

65 ponses and hypothesise new modes of pathogen immune evasion.

66 ng, highlighting a novel strategy for innate immune evasion.

67 of metastatic disease, which is dependent on immune evasion.

68 uses immune inhibitory receptors to achieve immune evasion.

69 e mutational inactivation of CREBBP promotes immune evasion.

70 regulators of host defense and mediators of immune evasion.

71 This immune evasion activity of Vif is dependent on the cellu

72 onses have the potential to exploit pathogen immune-evasion adaptations, a capability that might endo

73 ation of neutrophil activity is critical for immune evasion among extracellular pathogens, yet the me

74 mportant functions including DNA competence, immune evasion and biofilm formation.

75 rtant S. aureus virulence factor involved in immune evasion and biofilm formation.

76 expression can be altered as a mechanism of immune evasion and can have both diagnostic and prognost

77 ancer (PDAC), where it coordinately mediates immune evasion and drug resistance.

78 fusion activation, and defines parameters of immune evasion and immune recognition.

79 cell-mediated immunity, in part due to viral immune evasion and immunodeficiency resulting from CD4(+

80 hema in mouse models of NSCLC reverses tumor immune evasion and modulates T cell exhaustion state tow

81 genic signals, therefore, can mediate cancer immune evasion and resistance to immunotherapies, pointi

82 ression of cell surface proteins involved in immune evasion and stress responses; and (iv) attenuated

83 s reveal an essential role of CpsA in innate immune evasion and suggest that LCP proteins have functi

84 tic mechanisms by which T. pallidum promotes immune evasion and survival, and demonstrate the excepti

85 r a growth arrest of Salmonella facilitating immune evasion and the establishment of a long-term nich

86 Here, we review the role of NLRC5 in cancer immune evasion and the future prospects for cancer resea

87 suppressive enzyme in human tumors, leads to immune evasion and tumor tolerance.

88 e toxin-hemolysin (CyaA) plays a key role in immune evasion and virulence of the whooping cough agent

89 ed ways to exploit these cells, facilitating immune evasion and virus dissemination.

90 surveillance makes C3 a target for microbial immune evasion and, if improperly engaged, a trigger poi

91 accessory factor enhances viral infectivity, immune evasion, and AIDS progression.

92 f viral replication, viral persistence, host immune evasion, and cellular transformation--have been a

93 and exit dormancy, resistance to apoptosis, immune evasion, and co-option of other tumor and stromal

94 rovides mechanisms for parasite development, immune evasion, and disease pathology.

95 structural basis of resistance to apoptosis, immune evasion, and loss of cell junctions seen in H. py

96 ding of pathogenesis, antibiotic resistance, immune evasion, and mechanism of antimicrobial action.

97 n, metastasis, cancer stem cell maintenance, immune evasion, and resistance to chemotherapy and radia

98 ctural protein 1 (NS1), essential for innate immune evasion, and the nuclear export protein (NEP), re

99 a novel role for JAK2/STAT1 in EGFR-mediated immune evasion, and therapies targeting this signaling a

100 eoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prognosis of canc

101 serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and m

102 bility of HIV-1 target tissue broadening and immune evasion are considered.

103 Genomic instability and immune evasion are hallmarks of cancer.

104 ations suggest that bacterial metabolism and immune evasion are linked by virtue of this moonlighting

105 r validates E7 as a key component of the HPV immune evasion armor.

106 merging antibiotic resistance and formidable immune evasion arsenal have emphasized the need for more

107 In addition to multiple immune evasion-associated functions, EBV BILF1 has trans

108 these findings suggest a mechanism of viral immune evasion at the very earliest phase of infection.

109 presents a strategy that tumor cells use for immune evasion, but the underlying mechanisms are unclea

110 septicum-host interaction, pathogenesis, and immune evasion, but their exact role and the overall nat

111 Thus, ITAMi can be exploited for immune evasion by a pathogen and may represent a paradig

112 rk provides a clear molecular description of immune evasion by a persistent virus.

113 and its ability to assist the virus in rapid immune evasion by being prepackaged within the virion, t

114 ponema denticola FhbB protein contributes to immune evasion by binding factor H (FH).

115 ecruitment to tumors is a major mechanism of immune evasion by cancer cells, our data highlight the i

116 IDO1, KMO, KYNU) that play a pivotal role in immune evasion by certain other microbial pathogens by d

117 D47 is a cell-surface molecule that promotes immune evasion by engaging signal-regulatory protein alp

118 inflammatory forms of cell death, as well as immune evasion by establishing residency in M2 macrophag

119 duct of human cytomegalovirus promotes viral immune evasion by hijacking the endoplasmic reticulum (E

120 Immune evasion by HIV-1 during acute infection is critic

121 Our studies revealed a strategy of immune evasion by MNV via the induction of a CD8(+) T ce

122 tion of annexin1 is a critical mechanism for immune evasion by Mtb.

123 This work illustrates a striking example of immune evasion by persistent viruses.

124 l discuss the molecular mechanisms of innate immune evasion by select NNS viruses.

125 rate an important role for indolepyruvate in immune evasion by T. brucei.

126 The molecular mechanisms of immune evasion by the parasite are poorly understood.

127 receptor enzyme suspected to be involved in immune evasion by the parasite at the adult stage.

128 odium falciparum malaria pathogenesis and in immune evasion by the parasite.

129 mmunity and are therefore the key targets of immune evasion by the virus.

130 t a potential therapeutic target to overcome immune evasion by tumour cells.

131 efore, it may be possible to counteract EBOV immune evasion by using treatments that bypass the VP35-

132 N-glycan shielding is one mechanism by which immune evasion can be achieved.

133 Importantly, this mechanism of immune evasion can be circumvented with small-molecule C

134 understand the evolution of poxvirus innate immune evasion capabilities, providing a better understa

135 This viral immune evasion casts new light on the roles of CTLs and

136 ipulate the IL-10 response as a mechanism of immune evasion during chronic systemic and biofilm model

137 -risk HPV E7 may contribute to virus-induced immune evasion during HPV persistence.

138 ns that we hypothesize might facilitate host immune evasion during infection.

139 fic protein, ORF52, has an important role in immune evasion during KSHV primary infection, through in

140 in play important roles in pathogenicity and immune evasion during RABV infection.

141 t al. (2017) determine that norovirus innate immune evasion enables infection of intestinal epithelia

142 ligands indicated additional HBs-independent immune evasion events.

143 tify EBV-encoded miR-BART16 as a novel viral immune-evasion factor that interferes with the type I IF

144 plement system by upregulating expression of immune evasion factors in response to changes in tempera

145 within mRNAs control expression of bacterial immune evasion factors, including CssA, in the 5'-untran

146 which is attributable to a large spectrum of immune evasion factors.

147 o antigens that induce antibodies that block immune evasion from antibody and complement.

148 sights into the mechanisms of host and viral immune evasion from RIG-I, explaining the complexity of

149 ur results indicate that, in addition to its immune evasion function, KSHV ORF52 is required for the

150 rse microbial evolutionary relationships and immune evasion function.

151 ion in vitro Both viruses also encode innate immune evasion functions.

152 Deletion of immune evasion genes from the poxvirus genome is an attr

153 by the critical involvement of two putative immune evasion genes in FV3 resistance to IFN- and IFN-l

154 Dual deletion of type I and type II IFN immune evasion genes in NYVAC markedly enhanced its immu

155 Dual deletion of type I and type II IFN immune evasion genes in NYVAC poxvirus improves its immu

156 port that deletion of type I and type II IFN immune evasion genes in NYVAC poxvirus resulted in the r

157 eading frame 50 (ORF50), transcripts for the immune evasion genes K3 and K5 were detected, with some

158 Given that the virus expresses immune evasion genes or uses proteins with intrinsic pro

159 combinant viruses deficient for the putative immune evasion genes, the viral caspase activation and r

160 n the balance of E1A and E1B mRNAs and in E3 immune evasion genes.

161 onment and heterogeneous mechanisms of tumor immune evasion has also expanded.

162 We propose that Pfs47-mediated immune evasion has been critical for the globalization o

163 exclusion underpins antigenic variation and immune evasion in African trypanosomes.

164 A greater understanding of the processes of immune evasion in chronic infections and malignant tumor

165 Our findings demonstrate a mechanism of immune evasion in IDH-MUT gliomas and suggest that speci

166 Here we study the phenomena of immune evasion in malignant melanoma cells.

167 tutes a tumor-intrinsic mechanism underlying immune evasion in MIBC.

168 ) receptor and its ligand (PD-L1) facilitate immune evasion in multiple myeloma (MM).

169 Furthermore, this variant displays robust immune evasion in nonhuman primate and human serum sampl

170 PD-1-blocking antibody, could inhibit tumor immune evasion in patients with relapsed or refractory H

171 , we investigated the role of Pfs47-mediated immune evasion in the adaptation of P. falciparum to evo

172 Immune evasion in this developmental context entails sil

173 ltiple ways to promote viral replication and immune evasion in vivo.

174 ys, including cell signaling, cell cycle and immune evasion, in their development.

175 onment in nude mice, exhibited signatures of immune evasion, increased stemness, increased calcium si

176 ch plays critical roles in envelope folding, immune-evasion, infectivity, and immunogenicity.

177 PAF function, suggesting that mimicry-driven immune evasion is a common paradigm among respiratory pa

178 Although host immune evasion is a common strategy used by successful h

179 Immune evasion is a hallmark of cancer.

180 Immune evasion is a necessary feature of viruses that es

181 Immune evasion is an emerging hallmark of cancer progres

182 Among other potential explanations, immune evasion is considered to be a main driver of thei

183 alance between host immune control and viral immune evasion is pivotal to viral pathogenesis, and we

184 infection, suggesting that CpsY function in immune evasion is specific to the human host.

185 n modulate host immune responses, and innate immune evasion is thought to play a vital role in PRRSV

186 in herpes simplex virus, LAT functions as an immune evasion locus.

187 nts in microbial resilience to disturbances, immune evasion, maintenance of physiologic processes, an

188 ng acute myeloid leukemia (AML), its role in immune evasion may be just as important.

189 These results suggest a novel immune evasion mechanism by which the HSV-1 LAT may cont

190 s function may have evolved to counteract an immune evasion mechanism deployed by HSV-1.

191 An immune evasion mechanism employed by HSV-1 is retention

192 phisms at noncontact residues may be a major immune evasion mechanism for HCV, facilitating viral per

193 aken together, our findings indicate a novel immune evasion mechanism in which incorporation of host

194 esults identify a bacterium-dependent, tumor-immune evasion mechanism in which tumors exploit the Fap

195 These data describe a novel immune evasion mechanism of HAV.

196 These results represent a novel tumor immune evasion mechanism through impairing multiple comp

197 em has on iDC function could be an important immune evasion mechanism used by HIV-1 to establish infe

198 rotein kinase US3 plays a major role in this immune evasion mechanism, and its kinase activity is req

199 erum survival, but phase variation can be an immune evasion mechanism, and thus, this modification ma

200 r study reveals an EGFR-IFRD1-mediated viral immune evasion mechanism, which can also be exploited by

201 ifically targeted MOV10 as a possible innate immune evasion mechanism.

202 nd that proteolysis of galectin-3 is a novel immune evasion mechanism.

203 I interferon receptor IFNAR1 chain as a new immune-evasion mechanism in colorectal cancers.

204 silencing of TH1-type chemokines is a novel immune-evasion mechanism of tumours.

205 heir weak immunogenic nature and the various immune evasion mechanisms active in advanced tumors.

206 in a delicate balance between virus-encoded immune evasion mechanisms and host antiviral immunity.

207 EBV is an important human pathogen whose immune evasion mechanisms are only partly understood.

208 We also directly compare the innate immune evasion mechanisms between arenaviruses and other

209 Of the EBV immune evasion mechanisms identified to date, none could

210 Below we discuss immune evasion mechanisms in leukemia and lymphoma, high

211 odel thus permits examination of the role of immune evasion mechanisms in vivo.

212 many pathogens, whereas their involvement in immune evasion mechanisms is prominent among pathogens t

213 Observations: Immune evasion mechanisms of these viral infections have

214 in inhibition disrupts two major BF-specific immune evasion mechanisms that trypanosomes harness to e

215 This study suggests that EAV employs complex immune evasion mechanisms that warrant further investiga

216 osis survives within macrophages and employs immune evasion mechanisms to persist in the host.

217 virulence determinants, biofilm growth, and immune evasion mechanisms, comparatively little is known

218 ely targeted by Nef- and Vpu-dependent viral immune evasion mechanisms.

219 r insights regarding the pathogen's possible immune evasion mechanisms.

220 spond, suggesting existence of complementary immune evasion mechanisms.

221 tissues is associated with colonization and immune evasion mechanisms.

222 aled that NLRC5 is a major target for cancer immune evasion mechanisms.

223 , which complements the known PRRSV-mediated immune-evasion mechanisms.

224 growth/proliferation, self-renewal capacity, immune evasion, migration and invasion as well as resist

225 We recovered the known immune evasion molecules PD-L1 and CD47, and confirmed t

226 V lesions persist because of virally encoded immune evasion molecules that inhibit antiviral response

227 g, which suggests the presence of phagosomal immune evasion molecules.

228 nctions, despite the presence of CMV-encoded immune evasion molecules.

229 the two viruses and in the expression of E3 immune evasion mRNAs.

230 sly found that cHLs have a genetic basis for immune evasion: near-uniform copy number alterations of

231 n mechanistic differences in replication and immune evasion observed for MARV and EBOV.

232 e immune cells, which might both promote the immune evasion of Acanthamoeba and limit the induced inf

233 in this locus are not the sole mediators of immune evasion of African malaria parasites.

234 Our findings point to a mechanism of immune evasion of cells with a mesenchymal phenotype and

235 Therefore, Pic may contribute to immune evasion of E. coli and S. flexneri, favoring inva

236 study provides new insights on mechanisms of immune evasion of malaria parasites and highlights the i

237 rotein isoforms has possible implications in immune evasion of the obligate pathogen T. pallidum duri

238 suggests a potential active site modulating immune evasion of the Plasmodium parasite across patient

239 ion for LGALS3BP that might be important for immune evasion of tumor cells during cancer progression.

240 PD-L1 on tumor cells is sufficient for tumor immune evasion or simply correlates with an inflamed tum

241 are well characterized and knowledge of the immune evasion pathways exploited by these malignancies

242 This method of immune evasion poses a challenge for the development of

243 However, the immune evasion principles underlying serum resistance in

244 onment (TME), have emerged as key players in immune evasion programs that differentially control the

245 However, the multiple immune evasion properties of HIV have hampered these eff

246 ed in the structural strength, motility, and immune evasion properties of the infective sporozoites.

247 arr virus (EBV) BNLF2a gene product provides immune evasion properties to infected cells through inhi

248 (HSV-2) displays previously uncharacterized immune evasion properties toward NK cells.

249 P, may provide the sporozoites not only with immune evasion properties, but also with lubricating cap

250 nes enzyme with 5'-nucleotidase activity and immune evasion properties.

251 est the existence of a hitherto unidentified immune evasion protein further enhancing protection agai

252 ar fibrinogen-binding protein (Efb) is a key immune evasion protein of S. aureus that intercepts comp

253 The present work identifies an additional immune evasion protein, BDLF3, that is expressed late in

254 Vaccinia virus (VACV) encodes an innate immune evasion protein, E3, which contains an N-terminal

255 nucleosis and malignant tumors, harbors many immune-evasion proteins that manipulate the adaptive and

256 and the impact of this process on successful immune evasion, remain unclear.

257 s in expression of virulence factors, innate immune evasion, skin invasion, and virulence.

258 haracterization of the mechanisms underlying immune evasion strategies as well as the pathogenesis of

259 n Staphylococcus aureus has highly efficient immune evasion strategies for causing a wide range of di

260 nt significantly add to the understanding of immune evasion strategies of T. forsythia and expand the

261 Major neutralizing antibody immune evasion strategies of the HIV-1 envelope glycopro

262 r understanding of the immunosuppression and immune evasion strategies of these deadly viruses may gu

263 proteins (Env), gp120 and gp41, have evolved immune evasion strategies that render the elicitation of

264 ogether, our data further confirm that viral immune evasion strategies that target MIRRs can be trans

265 ium tuberculosis infection that orchestrates immune evasion strategies through the induction of NQO1

266 x virus 1 (HSV-1), have evolved a variety of immune evasion strategies to avoid being detected and de

267 Unfortunately, many cancer cells use immune evasion strategies to avoid their eradication by

268 ic responses is a prominent feature of viral immune evasion strategies to prevent premature clearance

269 infection is supported by a variety of viral immune evasion strategies, but, remarkably, 20% to 30% o

270 may have promoted the evolution of bacterial immune evasion strategies.

271 ced CD40-induced N-Ras activation as a novel immune evasion strategy and the potential for Ras isofor

272 Variation within this motif may provide an immune evasion strategy for transmitted/founder viruses

273 of MHC class I has been described as a major immune evasion strategy in many cancers.

274 edes Fc functionality and contributes to the immune evasion strategy of S. pyogenes.

275 flammatory cytokine secretion, perhaps as an immune evasion strategy or to postpone cytokine-induced

276 ce factor, and highlights a potential innate immune evasion strategy that may be employed by other ba

277 In conclusion, using a viral immune evasion strategy that shows broad immune-ablating

278 e E2(412-423) epitope, which may serve as an immune evasion strategy to impede induction of antibodie

279 Understanding this novel EBOV immune evasion strategy will provide valuable insights i

280 CV utilizes conformational flexibility as an immune evasion strategy, contributing to the limited imm

281 As part of EBV's immune evasion strategy, the virus encodes a multifuncti

282 with superinfection and may also serve as an immune evasion strategy.

283 This study characterizes an immune-evasion strategy used by malaria parasites and hi

284 nrichment and drug sensitivity identified an immune-evasion subtype that showed increased sensitivity

285 Focusing on the immune-evasion subtype, bioinformatic analysis of microR

286 croRNAs and downregulation of miR-29b in the immune-evasion subtype.

287 virus deploys GIF, a member of the poxvirus immune evasion superfamily, to antagonize GM-CSF (granul

288 locations of these loci, structural bases of immune evasion that are shared with PMBL.

289 mmune response to DENV and the mechanisms of immune evasion that DENV has developed to manipulate cel

290 ptive binK alleles promoted colonization and immune evasion that were mediated by cell-associated mat

291 n also fuels inflammation and supports tumor immune evasion, thereby serving as an immunological driv

292 Immune evasion through antigenic variation depends on ti

293 phenotype and suggest a strategy to overcome immune evasion through induction of the immunoproteasome

294 ly event in FL evolution that contributes to immune evasion via decreased antigen presentation.

295 ion, but its role in viral pathogenicity and immune evasion was not known.

296 the bacterial and host factors that lead to immune evasion, which can result in acute or chronic dis

297 of epitopes on viral envelopes vulnerable to immune evasion will aid in defining targets of vaccine i

298 ing the mechanisms of monkeypox virus innate immune evasion will help us to understand the evolution

299 These findings support a role for DC-HIL in immune evasion within the melanoma microenvironment.

300 aluation of mechanisms underlying CAR T cell immune evasion within the tumor microenvironment for the