ライフサイエンスコーパス: immune mechanism

1 inhibits HCV replication by a novel, innate immune mechanism.

2 N-gamma mice was not mediated by an adaptive immune mechanism.

3 evolutionary conservation of the underlying immune mechanism.

4 uted to the evolutionary preservation of the immune mechanism.

5 ous leukemia (CML), and evidence supports an immune mechanism.

6 cally reduces tumorigenicity, possibly by an immune mechanism.

7 plete knowledge of protective and pathogenic immune mechanism.

8 ary response integrating innate and adaptive immune mechanisms.

9 ection and elucidated C3a-dependent adaptive immune mechanisms.

10 rigorously maintained by a number of innate immune mechanisms.

11 , but little is known about their intestinal immune mechanisms.

12 imal models has impeded studies of antiviral immune mechanisms.

13 mplex underscore HCV-mediated attenuation of immune mechanisms.

14 confer comprehensive protection via multiple immune mechanisms.

15 ponse that includes both innate and adaptive immune mechanisms.

16 ted by activated innate immunity or acquired immune mechanisms.

17 provide insight into poorly understood host immune mechanisms.

18 ergy metabolism, gene expression, and innate immune mechanisms.

19 adaptive immune response more towards innate immune mechanisms.

20 pletion of T lymphocytes, implicating innate immune mechanisms.

21 in pathway, angiogenesis, AR chaperones, and immune mechanisms.

22 signals to macrophages, rather than adaptive immune mechanisms.

23 ccurs independently of conventional adaptive immune mechanisms.

24 , but little is known about their intestinal immune mechanisms.

25 sponses by reprogramming innate and adaptive immune mechanisms.

26 o antigens not studied here or through other immune mechanisms.

27 angiogenesis and the tolerance of tumours to immune mechanisms.

28 ed for disease, little is known about innate immune mechanisms.

29 irus infection because of other compensatory immune mechanisms.

30 nce of B. burgdorferi, presumably via innate immune mechanisms.

31 t is triggered by antigen-independent innate immune mechanisms.

32 in part to a combination of inflammatory and immune mechanisms.

33 evidence that this complication is caused by immune mechanisms.

34 suppressor mechanisms, pathogen insults, and immune mechanisms.

35 ped numerous ways to modulate host-initiated immune mechanisms.

36 y not be mediated by adaptive virus-specific immune mechanisms.

37 y to meningeal and pulmonary TB by different immune mechanisms.

38 both TLR2-dependent and -independent innate immune mechanisms.

39 -cell dependent) and type II (IgG dependent) immune mechanisms.

40 lied VSV depends on both innate and adaptive immune mechanisms.

41 y exclusive clinical phenotypes and opposing immune mechanisms.

42 uch as PSA, through both innate and adaptive immune mechanisms.

43 hrough the activation of innate and adaptive immune mechanisms.

44 gh tumor intrinsic [1,2,4,12], but also host immune mechanisms [17-23].

45 phenotype increases resistance against host immune mechanisms, a phenomenon that could contribute to

46 e 1 interferon (T1-IFN) signaling are innate immune mechanisms activated upon viral infection.

47 tory tract, a site where innate and adaptive immune mechanisms actively target infectious agents, we

48 The principal immune mechanism against biotrophic pathogens in plants

49 pe I interferons (IFN-I) is a crucial innate immune mechanism against viral infections.

50 ritical role in disease development, but the immune mechanisms against pathobionts remain poorly unde

51 Although bacterial innate immune mechanisms against phage abound, the only documen

52 Immune mechanisms also affect treatment outcome, and cer

53 s biology approach in studying tumor-related immune mechanism and consequent selection of therapeutic

54 clear to what extent genetic defects control immune mechanisms and confer resistance to T-cell-based

55 e regulation of hematopoiesis through innate immune mechanisms and illustrate the expansive cell-cell

56 sclerosis seems to result more from diffuse immune mechanisms and neurodegeneration.

57 range of functions that may drive unexpected immune mechanisms and provide new tools for immunotherap

58 ction, HIV-1 must counteract cellular innate immune mechanisms and redirect cellular processes toward

59 t decades, and several studies on underlying immune mechanisms and risk factors for formation of thes

60 However, its underlying immune mechanisms and the genetic etiology for differenc

61 ch provide a measure of a range of different immune mechanisms and their interactions.

62 mmation mediated by both innate and adaptive immune mechanisms and where the inflammatory response in

63 ns that thwart individual innate or adaptive immune mechanisms, and an overall replication strategy t

64 des allow us to target selectively different immune mechanisms, and certain of those show features th

65 ata suggest that many such reactions involve immune mechanisms, and genetic association studies have

66 T3SS effectors target host innate immune mechanisms, and T3SS-defective mutants are cleare

67 esponses, the effects of pathogens on innate immune mechanisms, and the potential impact of virally i

68 We investigated the immune mechanisms (antibody and T-cell responses) of lon

69 Our results show that innate immune mechanisms are activated immediately after influe

70 Conversely, innate immune mechanisms are also central to noninflammatory cl

71 Innate immune mechanisms are crucial in defense against bacteri

72 Negative feedback immune mechanisms are essential for maintenance of hepat

73 m genome-wide studies, showing that not only immune mechanisms are important determinants of host res

74 Immune mechanisms are involved in the pathophysiology of

75 monstrated that multiple innate and adaptive immune mechanisms are necessary for efficient antiviral

76 Innate immune mechanisms are not so effective against biofilms

77 inflammatory phase, both innate and adaptive immune mechanisms are operative.

78 Intrinsic innate immune mechanisms are the first line of defense against

79 esist bubonic plague and used it to identify immune mechanisms associated with resistance.

80 Insights into the immune mechanisms at play in skin diseases including acn

81 These studies indicate that innate immune mechanisms bridge to and enhance the adaptive imm

82 MicroRNAs (miRNAs) regulate specific immune mechanisms, but their genome-wide regulation of T

83 These studies define an innate immune mechanism by which pathogenic fungi regulate host

84 n of CXCR4-regulated tumoral, stem cell, and immune mechanisms by adjunctive CXCR4 antagonists may he

85 e T4SS may contribute to evasion of adaptive immune mechanisms by B. abortus.

86 athogenic Yersinia species neutralize innate immune mechanisms by injecting type three secretion effe

87 The immune mechanisms by which early host-mycobacterium inte

88 contribute to a better understanding of the immune mechanisms by which the hygiene hypothesis operat

89 The data also delineate innate immune mechanisms by which TLI/ATS/CTX conditioning may

90 erspective on how understanding tissue-based immune mechanisms can be used to guide therapeutic appro

91 Although immune mechanisms can suppress tumour growth, tumours es

92 ipheral immune response or by endogenous CNS immune mechanisms, can affect CNS neurodegeneration.

93 immunopathology, mediated through different immune mechanisms, can influence parasite fitness and ho

94 In addition, SPBAANGAS-GAS-GAS induces immune mechanisms capable of containing a CNS infection

95 To dissect the difference in protective immune mechanisms conferred by these two vaccine strains

96 Evidence suggests that immune mechanisms contribute to myocardial injury and fi

97 Thus, unique immune mechanisms contribute to the differential respons

98 rkers that reflect inflammatory or cytotoxic immune mechanisms contributing to its onset.

99 ase (IDO) is believed to be the major innate immune mechanism controlling C. trachomatis infection in

100 ic risk is shared, affecting function of the immune mechanisms controlling self-tolerance.

101 However, the innate immune mechanisms controlling sunburn development are no

102 ation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or pr

103 inst carriage is serotype specific and which immune mechanisms drive carriage.

104 rtant first step to identifying dysregulated immune mechanisms driving adverse maternal or neonatal o

105 estigate the maturation of pulmonary mucosal immune mechanisms during early life because they are mos

106 Currently, the immune mechanisms elicited during biofilm growth and the

107 course will improve our understanding of how immune mechanisms evolve and guide the introduction of n

108 timal resistance to both innate and adaptive immune mechanisms following needle inoculation.

109 In this article, we describe an immune mechanism for inflammatory activation of human br

110 tive neutrophil function are critical innate immune mechanisms for bacterial clearance.

111 Eukaryotes employ complex immune mechanisms for protection against microbial patho

112 s-tumor responses and dissect the underlying immune mechanisms for this, we compared the ability of H

113 While many studies have focused on immune mechanisms for trachoma during chronic stages of

114 Because of this long history, innate immune mechanisms found in modern eukaryotic organisms t

115 Here, we report a novel innate immune mechanism functioning against respiratory syncyti

116 To understand the underlying immune mechanisms, graft infiltrating and peripheral blo

117 Genes involved in both adaptive and innate immune mechanisms have been identified, notably includin

118 ver 30 years, and both melanocyte stress and immune mechanisms have been thought to be mutually exclu

119 ounteract these elements, a number of innate immune mechanisms have evolved that can lead to lung inf

120 Immune mechanisms have evolved to cope with local entry

121 Studies of plant immune mechanisms have led to strategies of engineering

122 eral theories, involving both immune and non-immune mechanisms, have been proposed.

123 Immune mechanisms important in asthma such as Th2 cells

124 results suggest that ADCC might be an active immune mechanism in EC that helps to maintain durable su

125 alloantibodies cannot solely account for the immune mechanism in platelet refractoriness.

126 These findings support an immune mechanism in the etiology of childhood ALL involv

127 nity for harnessing an endogenous protective immune mechanism in the treatment of sepsis.

128 ur current understanding of inflammatory and immune mechanisms in atherosclerosis.

129 ovel role for Th1 and Th17-mediated adaptive immune mechanisms in chronic pelvic pain.

130 us spread or the appearance of RABV-specific immune mechanisms in CNS tissues.

131 study was undertaken to investigate possible immune mechanisms in fatal herpes simplex virus type 1 (

132 c diseases, identification of new allergens, immune mechanisms in host defense, factors involved in a

133 characterization of the innate and adaptive immune mechanisms in human iPSC lines derived from perip

134 To investigate potential adaptive immune mechanisms in IPF, we compared phenotypes and eff

135 An involvement of immune mechanisms in its pathophysiology has been propos

136 ges of infection, less research has targeted immune mechanisms in primary ocular infections, events t

137 e focuses on the role of adaptive and innate immune mechanisms in the pathogenesis of celiac disease

138 ncreasing evidence for involvement of innate immune mechanisms in the pathogenesis of idiopathic infl

139 sociation studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclero

140 Mucosal immune mechanisms in the upper and lower respiratory tra

141 ssed patients demonstrates the importance of immune mechanisms in this therapy, and transplant recipi

142 poptosis of tumor cells and triggers several immune mechanisms, including a T-helper type 1 (T(H)1) r

143 remaining question is whether virus-specific immune mechanisms, including cytotoxic T lymphocytes (CT

144 stigation of evolutionarily conserved innate immune mechanisms, including NF-kappaB-dependent transcr

145 study presents new insight into fundamental immune mechanisms, including the chemotactic recruitment

146 t it is currently unknown how cutaneous host immune mechanisms influence the composition, diversity,

147 The pathogenetic immune mechanisms involved (cell-mediated versus humoral

148 ghts into the comprehensive understanding of immune mechanisms involved during primary HCMV infection

149 dimension to our understanding of the innate immune mechanisms involved in controlling intramacrophag

150 proaches to T1D, and how these relate to the immune mechanisms involved in disease development.

151 his study provide more details on the innate immune mechanisms involved in DNA vaccination and furthe

152 current understanding of the cell types and immune mechanisms involved in each of these steps leadin

153 of this study was to identify the underlying immune mechanisms involved in formation of inflammatory

154 to the interplay between adaptive and innate immune mechanisms involved in HIV-1 immunity and unveil

155 erapy (SLIT) and to begin to investigate the immune mechanisms involved in successful immunotherapy w

156 We investigate here the immune mechanisms involved in the development of CLAD af

157 do not use injection drugs suggests that the immune mechanisms involved with a successful response to

158 evelop or be greatly enhanced through innate immune mechanisms involving IL-33, natural helper cells,

159 Signaling via innate immune mechanisms is considered pivotal for T cell-media

160 HER3 signaling in tumors influences cellular immune mechanisms is therefore warranted.

161 ulative effect of these eosinophil-dependent immune mechanisms is to promote the Th2 polarization cha

162 ion injury (IRI), but the role of regulatory immune mechanisms is unknown.

163 olled drug-resistant disease through a novel immune mechanism, it may offer a fine strategy for salva

164 The immune mechanism leading to the generation of protective

165 Immune mechanisms leading to aSS could be initiated in t

166 Innate immune mechanisms leading to liver injury subsequent to

167 ity and mortality, yet little is known about immune mechanisms leading to NV control.

168 a mouse model that allows deciphering of the immune mechanisms leading to orexin(+) neuron loss and n

169 To evade host immune mechanisms, many bacteria secrete immunomodulator

170 erns of demyelination suggest that different immune mechanisms may be involved in tissue damage.

171 ria and cardiovascular risk, suggesting that immune mechanisms may contribute to the development of d

172 Stimulation of multiple innate immune mechanisms may prove a generalizable property of

173 oocysts, without considering that different immune mechanisms may target different developmental sta

174 stulates that CS therapy, by reducing innate immune mechanisms, may promote C. albicans colonization

175 t the patients' tumor and suggesting that an immune mechanism mediating the observed antitumor effect

176 Viral interference and innate antiviral immune mechanisms might be more important determinants o

177 this novel concept of modulating endogenous immune mechanisms might be translated to a broad spectru

178 gh increased antigen penetration, additional immune mechanisms might explain the increased susceptibi

179 the interplay between virulence factors and immune mechanisms might have evolved to benefit both par

180 y important for understanding the protective immune mechanisms needed to protect an immunocompromised

181 a knockin approach can provide insight into immune mechanisms not possible using conventional geneti

182 The findings establish a candidate innate immune mechanism of action for a human autoimmunity "ris

183 The immune mechanism of ALP-induced severe cutaneous adverse

184 , revealing a previously unrecognized innate immune mechanism of intestinal tissue protection.

185 r and humoral immune responses; however, the immune mechanism of protection remains unknown.

186 We sought to study the immune mechanism of TH2/TH17-predominant and TH2/TH17-lo

187 ars increasingly clear that not only are the immune mechanisms of allergy and anti-helminth immunity

188 as identify gaps in our knowledge about the immune mechanisms of allergy and tolerance to foods.

189 recent developments in our understanding of immune mechanisms of clinical manifestations of food all

190 As such, a deeper understanding of the immune mechanisms of conventional and targeted cancer th

191 The innate immune mechanisms of host cells are diverse in nature an

192 s lagged far behind our understanding of the immune mechanisms of IgE-mediated food allergy.

193 gh most attention has been focused on innate immune mechanisms of inflammatory carcinogenesis, more r

194 the pathophysiology of food allergy and the immune mechanisms of oral tolerance.

195 scientific information available concerning immune mechanisms of protection allow protection in the

196 However, the immune mechanisms of protection conferred by this vaccin

197 nd is valuable for clarifying nonimmune (and immune) mechanisms of demyelination induced by TMEV as w

198 e earlier and stronger effects than top-down immune mechanisms on within-host community dynamics.

199 opulations, passively and naturally acquired immune mechanisms operating faster than pitting may exis

200 These data highlight the redundant immune mechanisms operative at this mucosal site and the

201 Rather, innate immune mechanisms or an intact epithelial barrier may be

202 cterial resistance to an IFN-gamma-dependent immune mechanism other than NOS2.

203 ate that flagellin induces additional innate immune mechanisms over those induced by VSV alone.

204 it has to avoid being killed by host innate immune mechanisms, particularly the complement system.

205 tivities of other essential type-2-dependent immune mechanisms, Pla2g1b(-/-) mice failed to expel the

206 r of activated B cells (NF-kappaB)-dependent immune mechanisms plays a major role in the pathogenesis

207 Immune mechanisms preventing inappropriate immune reacti

208 dels for this disease; therefore, underlying immune mechanisms regulating GM-CSF-specific IgG in aPAP

209 odium immunity is multimodal, with different immune mechanisms regulating ookinete and oocyst surviva

210 allows the investigation of T cell-mediated immune mechanisms relevant to vaccine design.

211 rgeted by peroral arsenic and the associated immune mechanisms remain poorly defined.

212 cers, but its effect on endogenous antitumor immune mechanisms remains largely unknown.

213 Evaluation of immune mechanisms required for bacterial containment and

214 To understand the immune mechanisms required for the rapid control of bact

215 Identifying immune mechanisms responsible for antibody-mediated reje

216 rejection and could provide insight into the immune mechanisms responsible for lung allograft rejecti

217 e we review our current understanding of the immune mechanisms responsible for oral tolerance and how

218 Immune mechanisms responsible for pathogen clearance fro

219 here is little knowledge about the long-term immune mechanisms responsible for sustained allergen tol

220 experimental and clinical studies; however, immune mechanisms responsible for this sex-based dispari

221 cute stages of the infection and analyze the immune mechanisms responsible for viral clearance.

222 To analyze the immune mechanisms responsible for viral control, five ma

223 A better understanding of oral mucosal immune mechanisms should lead to improved prevention of

224 teractions between the microbiota and innate immune mechanisms, such as the inflammasome-mediated res

225 itors with anti-tumor activity likely via an immune mechanism, supporting SHP-1 as a novel target for

226 IDO1 is a lung-specific innate immune mechanism that controls pulmonary Francisella inf

227 ngs reveal that RegIIIgamma is a fundamental immune mechanism that promotes host-bacterial mutualism

228 cells is emerging as the key maternal-fetal immune mechanism that regulates placentation.

229 Protection appears to be by immune mechanisms that allow SLE-prone mice better to co

230 This study provides evidence for specific immune mechanisms that are associated with a model of op

231 e present therapies that target inflammatory/immune mechanisms that are currently enrolling patients,

232 provide a new understanding of the intrinsic immune mechanisms that can contribute to the onset of ir

233 t is important to identify negative feedback immune mechanisms that can regulate T cell activity.

234 Many of the details of immune mechanisms that change with age are currently not

235 in PBMC.IMPORTANCE The detailed knowledge of immune mechanisms that contribute to HIV control is a pr

236 eu mAb (4D5) would enhance the FcR-dependent immune mechanisms that contribute to its antitumor activ

237 scored the incomplete understanding of basic immune mechanisms that contribute to the pathogenesis of

238 Imbalance in the regulatory immune mechanisms that control intestinal cellular and b

239 kines in murine bone marrow and the cellular immune mechanisms that control local cytokine secretion

240 ver an intricate relationship between innate immune mechanisms that control response to self and to r

241 ulosis infection and to ascertain protective immune mechanisms that could be exploited to develop mor

242 ngal pathogens depends on subversion of host immune mechanisms that detect conserved cell wall compon

243 raft survival, and ignore specific risks and immune mechanisms that differentially contribute to allo

244 The precise immune mechanisms that drive the progression from benign

245 As such, understanding the innate immune mechanisms that enable this T cell response has i

246 y cirrhosis (PBC) result from failure in the immune mechanisms that establish and maintain self-toler

247 een monkey (AGM) model was used to elucidate immune mechanisms that facilitate viral clearance but ma

248 In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid

249 ells and allergic effector cells by adaptive immune mechanisms that involve allergen-specific IgG1 an

250 Identifying the immune mechanisms that lead to control of initial infect

251 e its host, balanced with sophisticated host immune mechanisms that maintain viral latency.

252 field, and on consideration of the allergic immune mechanisms that may influence positive or negativ

253 r persistence in vaccinated animals, and the immune mechanisms that mediate protection are unknown.

254 d developed, deployed, and optimized complex immune mechanisms that monitor and control this microbia

255 Understanding the early innate immune mechanisms that participate in the development of

256 olve within the context of self-tissues, the immune mechanisms that prevent the autoimmune attack of

257 However, the innate immune mechanisms that promote natural antitumor T cell

258 our understanding of the innate and adaptive immune mechanisms that protect against ubiquitous fungal

259 This study details enhancement of numerous immune mechanisms that provide an explanation for the im

260 The immune mechanisms that provoke concomitant inflammation

261 lar watershed following activation of innate immune mechanisms that provoke hypoxia, and superoxide a

262 nd epithelial barrier repair, yet the innate immune mechanisms that selectively drive GC functions ha

263 Defining immune mechanisms that suppress the underlying Th2-drive

264 We show that the two immune mechanisms that target ookinetes-epithelial nitra

265 Immune mechanisms that terminate acute HAV infection, an

266 To determine an underlying immune mechanism, the murine B16 melanoma model and the

267 significantly to our understanding of basic immune mechanisms, the involvement of cytokines in sever

268 essential determinants of the circadian and immune mechanisms, the transcription factors CLOCK and N

269 As with many immune mechanisms, there is a degree of functional overl

270 ll growth with the promotion of the adaptive immune mechanisms through the stimulation of DC maturati

271 o find empirical support for behavioural and immune mechanisms through which human-provided resources

272 s) act in an evolutionarily conserved innate immune mechanism to provide essential protection for ger

273 rscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

274 efense that includes physical, chemical, and immune mechanisms to combat environmental stress.

275 ediated immune responses can regulate innate immune mechanisms to defend against microbial pathogens.

276 ic sites of the body employ different innate immune mechanisms to defend against potential infections

277 gical organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens

278 d that PSA requires both innate and adaptive immune mechanisms to generate protection.

279 system integrates with more primitive innate immune mechanisms to maintain immune homeostasis, holds

280 results suggest that tadpoles use different immune mechanisms to resist different stages of trematod

281 evolved to subvert these organ-specific host immune mechanisms to survive and grow in infected organs

282 ntal factors could foster the involvement of immune mechanisms to the abnormal developmental trajecto

283 is of the transition from reliance on innate immune mechanisms to the appearance of adaptive immunity

284 murine leukemia virus (MuLV) via an adaptive immune mechanism, to assess the contribution of cellular

285 noted in clinical outcomes and modulation of immune mechanisms toward effective therapy.

286 ew recently published data that suggest that immune mechanisms underlie most of these observed epidem

287 A key immune mechanism underlying the safety of VSVDeltaG-CHIK

288 fic T effector cells appear to be one of the immune mechanisms underlying immunity against tuberculos

289 This study provides insights into the immune mechanisms underlying the protective role of GBV-

290 will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

291 rains that control retroviruses via adaptive immune mechanisms, we found that of all steps in viral r

292 Host immune mechanisms were involved in tumor elimination bec

293 ance when given intranasally and induce both immune mechanisms when injected.

294 Rather, HD6 possesses a unique innate immune mechanism whereby it self-assembles into oligomer

295 These results identify a cellular immune mechanism whereby TGF-beta signaling blockade lic

296 These data indicate that an innate immune mechanism which is present from birth i.e., IgM-A

297 Some approaches suppress CNS immune mechanisms, while others harness the immune syste

298 es of genetic-environmental interactions and immune mechanisms will lead to better therapeutics.

299 of the intestinal microbiota in shaping host immune mechanisms, with particular emphasis on allergic

300 Little is known about innate immune mechanisms within the cardiac myocyte that determ