ライフサイエンスコーパス: immune reconstitution

1 w-level viral replication to thereby improve immune reconstitution.

2 val after RCI by regulating myelopoiesis and immune reconstitution.

3 luence the survival of T cells during normal immune reconstitution.

4 ation, innate immune activation, and reduced immune reconstitution.

5 perienced immune system may affect antiviral immune reconstitution.

6 ery of thymic activity in adults, leading to immune reconstitution.

7 ttle is known about these populations during immune reconstitution.

8 recovery or worsen outcomes associated with immune reconstitution.

9 graft-versus-host reactions permits superior immune reconstitution.

10 m/progenitor cells, ADA gene expression, and immune reconstitution.

11 are generated after infection, also promote immune reconstitution.

12 tion has been reported to result in enhanced immune reconstitution.

13 d thus may be a determinant of the extent of immune reconstitution.

14 active or recently treated PCP subjected to immune reconstitution.

15 e, such as in the fetus and neonate or after immune reconstitution.

16 graft-versus-malignancy and promoting rapid immune reconstitution.

17 the tumor-specific T-cell compartment during immune reconstitution.

18 to depletion of CD4(+) T cells and limiting immune reconstitution.

19 y and oxidative stress and an improvement in immune reconstitution.

20 e cases the brain can become a target of the immune reconstitution.

21 atory T cells in opportunistic infection and immune reconstitution.

22 factor that limits approaches to accelerate immune reconstitution.

23 ixed chimerism result in clinically relevant immune reconstitution.

24 y immunodeficiency that is caused by delayed immune reconstitution.

25 ents in those who have achieved CMV-specific immune reconstitution.

26 m followed by graft reinfusion for blood and immune reconstitution.

27 r many disorders, is intertwined with T cell immune reconstitution.

28 nt as adjunctive therapy with ART to improve immune reconstitution.

29 ore reduce treatment duration and facilitate immune reconstitution.

30 ded engraftment, acute and chronic GVHD, and immune reconstitution.

31 he mechanism of Treg-dependent regulation of immune reconstitution.

32 may be related to T-cell repopulation and/or immune reconstitution.

33 lead to resolution of viremia without T-cell immune-reconstitution.

34 e alloreactive lymphocytes and have compared immune reconstitution after allodepleted donor T cells w

35 In patients with HIV, immune reconstitution after antiretroviral therapy (ART)

36 pair the survival of naive T cells and limit immune reconstitution after antiretroviral therapy.

37 Here, we evaluated immune reconstitution after autologous CD34(+) PBPC tran

38 humans, rhesus macaques, and mice, and with immune reconstitution after chemotherapy and autologous

39 y a disease flare and HBV DNA clearance with immune reconstitution after chemotherapy is stopped.

40 -IL-22-TEC axis may be useful for augmenting immune reconstitution after clinical hematopoietic trans

41 Immune reconstitution after HAART initiation did not res

42 g the beneficial effects of this approach to immune reconstitution after haplo-HSCT.

43 nitoring of lymphoid malignancies, assessing immune reconstitution after hematopoietic cell transplan

44 t-IgG)-cultured cells for accelerating early immune reconstitution after hematopoietic cell transplan

45 red DC provides a novel strategy for de novo immune reconstitution after human HCT and a practical an

46 valuate the incidence of late infections and immune reconstitution after preemptive R treatment of EB

47 -versus-host disease (GVHD), GVL effect, and immune reconstitution after transplant.

48 n before treatment and affects the extent of immune reconstitution after treatment.

49 Immune-reconstitution after highly active antiretroviral

50 It is associated with better immune reconstitution and a quite powerful graft-versus-

51 ory T (T(SCM)) cells, which possess superior immune reconstitution and antitumor response capabilitie

52 However, delayed immune reconstitution and associated infectious morbidit

53 Detailed analysis of T- and B-cell immune reconstitution and donor chimerism was compared b

54 0, 1.08], respectively) after accounting for immune reconstitution and graft-versus-host disease.

55 IT and reduced GvHD severity independent of immune reconstitution and graft-versus-tumor effects.

56 Secondary outcomes included measures of immune reconstitution and HIV resistance.

57 determined whether the iC9-T cells produced immune reconstitution and if any resultant graft-versus-

58 These data suggest that immune reconstitution and immunocompetence are maintaine

59 We prospectively evaluated immune reconstitution and immunocompetence.

60 late, and no antithymocyte globulin (ATG) on immune reconstitution and outcome.

61 y T cells (Tregs) have been shown to enhance immune reconstitution and prevent graft-versus-host dise

62 Therefore, we investigated their role during immune reconstitution and re-establishment of immune tol

63 invasive CMV disease in its relationship to immune reconstitution and viral dynamics.

64 The 2 groups had comparable immune-reconstitution and viral burden.

65 T cells resulted in consistent engraftment, immune reconstitution, and acceptable rates of GVHD.

66 posi's sarcoma did not always correlate with immune reconstitution, and activity against other solid

67 pairment of MMUD RIC HSCT, can enhance early immune reconstitution, and appears to be suitable for pr

68 to engraftment, lineage-specific chimerism, immune reconstitution, and discontinuation of immunoglob

69 went homeostatic peripheral expansion during immune reconstitution, and in lymphopenic individuals re

70 K cells influenced donor T-cell engraftment, immune reconstitution, and long-term outcomes in childre

71 T-cell dosing as it relates to engraftment, immune reconstitution, and relapse.

72 on, ganciclovir resistance, quality of life, immune reconstitution, and safety.

73 ic in vitro derived effector CD8 T cells for immune reconstitution approaches, which would be amenabl

74 on or through improvements in the quality of immune reconstitution are required.

75 decreased GVHD, but hematologic recovery and immune reconstitution are slow.

76 r extreme longevity and robust potential for immune reconstitution, are central players in many physi

77 findings suggest T-cell repopulation and/or immune reconstitution as putative mechanisms for bone lo

78 neumocystis infection both in the setting of immune reconstitution as well as new acquisition of infe

79 Patients with superior immune reconstitution, as defined by an increase in seru

80 long-term follow-up and detailed analysis of immune reconstitution associated with a different suicid

81 sistent hemorheologic abnormalities, despite immune reconstitution associated with potent antiretrovi

82 rms of stem cell transduction and subsequent immune reconstitution, but have also highlighted the pot

83 a (GVL) effect, as well as the impairment of immune reconstitution by immunomodulatory drugs leading

84 Our results indicate that Tregs enhance immune reconstitution by preventing GvHD-induced damage

85 proof that the goal of controlled selective immune reconstitution can be achieved is still awaited.

86 treatment preserved long-term posttransplant immune reconstitution characterized by more donor thymic

87 nticipated by CMV viremia, and (3) no T-cell immune reconstitution despite previous viremia episodes.

88 ent for older XSCID children with inadequate immune reconstitution despite prior bone marrow transpla

89 the majority of T cells supporting long-term immune reconstitution did not carry the suicide gene and

90 ce injected with CD4 T cells also develop an immune reconstitution disease (IRD) manifesting as weigh

91 Immune reconstitution disease (IRD) represents a syndrom

92 resurgent CD4 T cells, a phenomenon known as immune reconstitution disease.

93 Long-term immune reconstitution does not explain this event, which

94 hes to moderate T cell depletion and improve immune reconstitution during HIV-1 infection.

95 The patient seroconverted after immune reconstitution during receipt of highly active an

96 patterns and kinetics of CMV-specific T-cell immune reconstitution: during the early time-points, pat

97 ificant differences in the profile of T-cell immune reconstitution emerged between D+ and D-.

98 compatibility complex HLA alleles, influence immune reconstitution, especially when HAART is initiate

99 Antiretroviral therapy (ART)-mediated immune reconstitution fails to restore the capacity of t

100 n African setting, and how this changes with immune reconstitution following HAART is unknown.

101 fected Malawian adults and then investigated immune reconstitution following HAART.

102 ed HIV load prior to HAART (P=.005) and poor immune reconstitution following initiation of HAART (P=.

103 ic variability of immune response to HIV and immune reconstitution following initiation of highly act

104 Efforts to augment GVL and immune reconstitution have been limited by GVHD, the att

105 Attempts to improve immune reconstitution have until now been unsuccessful,

106 Following immune reconstitution, hematopoietic stem cell transplan

107 Even with suppression of viral loads and immune reconstitution, HIV-positive individuals exhibit

108 of JCV VP1-specific T-cell responses during immune reconstitution in 1 of the patients.

109 ly analyze and compare clinical outcomes and immune reconstitution in 13 consecutive SCID-X1 patients

110 We monitored T(reg)s during immune reconstitution in 21 patients with leukemia under

111 tus, mechanism, and clinical implications of immune reconstitution in adults with hematologic maligna

112 herapeutic thymus restoration and peripheral immune reconstitution in adults.

113 with hematopoietic engraftment and improved immune reconstitution in allo-HSCT recipients with aGVHD

114 nst malaria and non-malaria infections after immune reconstitution in ART-treated individuals in sub-

115 of adjunctive antifibrotic agents to improve immune reconstitution in HIV infection.

116 ale for consideration of IL-7 as an agent of immune reconstitution in HIV-1 infection.

117 the gut that could prevent efficient mucosal immune reconstitution in HIV-infected individuals despit

118 populations, cellular immune activation, and immune reconstitution in HIV-infected individuals receiv

119 Influenza-specific CD4(+) T-cell immune reconstitution in HIV-infected patients on HAART

120 ontribution of this subset to posttransplant immune reconstitution in humans.

121 ffective therapy for selective CD4(+) T-cell immune reconstitution in hypoleptinemic states such as t

122 We monitored T(reg) cells during immune reconstitution in individuals with cancer who did

123 exerts marked stimulating effects on T cell immune reconstitution in mice and primates.

124 evere combined immune deficiency can lead to immune reconstitution in most patients, although a minor

125 cytes expressing a safety switch may promote immune reconstitution in patients undergoing haploidenti

126 immune repertoire, we examined the long-term immune reconstitution in patients with MS who received H

127 HIV-1-infected subjects generally allows for immune reconstitution in peripheral blood, reconstitutio

128 omogenate were increased following CD4+CD25- immune reconstitution in Pneumocystis-infected SCID mice

129 the gene into donor T cells given to enhance immune reconstitution in recipients of haploidentical st

130 n the decision to stop CTX after ART-induced immune reconstitution in regions with high infectious di

131 on of inflammation and facilitation of rapid immune reconstitution in those with only a limited respo

132 uman hematopoietic progenitors and performed immune reconstitutions in NOD/LtSz-scid IL2Rgamma(null)

133 Therefore, partial immune-reconstitution in AIDS, attributable to reduced t

134 Thymopoietic failure characterized post-CBT immune reconstitution, in marked contrast to results in

135 gmented and accelerated cellular and humoral immune reconstitution, including antitumor immunity, aft

136 e aGvHD but profoundly impairs donor-derived immune reconstitution, increasing infection and disease

137 Cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) may

138 ioration, known as cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS), up

139 sed by paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS).

140 Adverse events, including CM immune reconstitution inflammatory syndrome (CM-IRIS), a

141 Central nervous system-immune reconstitution inflammatory syndrome (CNS-IRIS) i

142 thogens in HIV-infected patients who develop immune reconstitution inflammatory syndrome (IRIS) after

143 The immunopathogenesis of CM immune reconstitution inflammatory syndrome (IRIS) after

144 velop active cytomegalovirus retinitis as an immune reconstitution inflammatory syndrome (IRIS) after

145 losis are at risk of tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) and d

146 Cryptococcal meningitis (CM)-related immune reconstitution inflammatory syndrome (IRIS) compl

147 Patients who experienced immune reconstitution inflammatory syndrome (IRIS) event

148 deficiency virus (HIV) is the development of immune reconstitution inflammatory syndrome (IRIS) in ap

149 Immune reconstitution inflammatory syndrome (IRIS) in hu

150 arly detection of MRI findings suggestive of immune reconstitution inflammatory syndrome (IRIS) in na

151 The immunopathogenesis of immune reconstitution inflammatory syndrome (IRIS) in pa

152 ring the HIV epidemic and the development of immune reconstitution inflammatory syndrome (IRIS) in pa

153 or HIV infection and can cause a devastating immune reconstitution inflammatory syndrome (IRIS) in th

154 Immune Reconstitution Inflammatory Syndrome (IRIS) is a

155 Immune reconstitution inflammatory syndrome (IRIS) is a

156 Tuberculosis immune reconstitution inflammatory syndrome (IRIS) is a

157 Immune reconstitution inflammatory syndrome (IRIS) is a

158 Immune reconstitution inflammatory syndrome (IRIS) is a

159 Immune reconstitution inflammatory syndrome (IRIS) is a

160 Immune reconstitution inflammatory syndrome (IRIS) is a

161 The management of corticosteroid refractory immune reconstitution inflammatory syndrome (IRIS) is cu

162 Furthermore, the role of unmasking immune reconstitution inflammatory syndrome (IRIS) is un

163 Immune reconstitution inflammatory syndrome (IRIS) refle

164 mmunopathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) remai

165 Concerns about the immune reconstitution inflammatory syndrome (IRIS) remai

166 Immune reconstitution inflammatory syndrome (IRIS) was r

167 with raised intracranial pressure (ICP) and immune reconstitution inflammatory syndrome (IRIS) were

168 The incidence of immune reconstitution inflammatory syndrome (IRIS) when

169 the CSF even though all patients experienced immune reconstitution inflammatory syndrome (IRIS), 11 p

170 relapse of talaromycosis, development of the immune reconstitution inflammatory syndrome (IRIS), and

171 hen administered postinfection in a model of immune reconstitution inflammatory syndrome (IRIS), both

172 these patients is neurological tuberculosis-immune reconstitution inflammatory syndrome (IRIS), but

173 All of them experienced immune reconstitution inflammatory syndrome (IRIS), but

174 systemic infection with Tropheryma whipplei, immune reconstitution inflammatory syndrome (IRIS), is a

175 This clinical response, known as the immune reconstitution inflammatory syndrome (IRIS), occu

176 cal outcome of PML and PML in the setting of immune reconstitution inflammatory syndrome (IRIS), we t

177 mary outcomes: mortality, drug toxicity, and immune reconstitution inflammatory syndrome (IRIS).

178 tory symptoms that are collectively known as immune reconstitution inflammatory syndrome (IRIS).

179 oorly understood inflammatory disease termed immune reconstitution inflammatory syndrome (IRIS).

180 ays to a few weeks after PLEX, indicative of immune reconstitution inflammatory syndrome (IRIS).

181 ial translocation for their association with immune reconstitution inflammatory syndrome (IRIS).

182 cult to interpret secondary to KS-associated immune reconstitution inflammatory syndrome (IRIS).

183 elerates fungal clearance during PcP-related immune reconstitution inflammatory syndrome (IRIS).

184 iral therapy (ART), perhaps due to unmasking immune reconstitution inflammatory syndrome (IRIS).

185 isk factors for tuberculosis (TB)-associated immune reconstitution inflammatory syndrome (IRS) in sol

186 87 (10%) of 834 versus 84 (10%) of 841 had immune reconstitution inflammatory syndrome (p=0.56).

187 sis ('inflammatory PML'), reminiscent of PML-immune reconstitution inflammatory syndrome (PML-IRIS).

188 cal leukoencephalopathy (PML) and full-blown immune reconstitution inflammatory syndrome (PML-IRIS).

189 Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) co

190 Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) fr

191 Tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in

192 HIV-tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is

193 nesis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) re

194 of HIV-1-infected TB patients at risk of TB immune reconstitution inflammatory syndrome (TB-IRIS), i

195 re all-cause mortality and the TB-associated immune reconstitution inflammatory syndrome (TB-IRIS).

196 ing antiretroviral therapy (ART) may develop immune reconstitution inflammatory syndrome (TB-IRIS).

197 orted in treated HIV patients, including CNS immune reconstitution inflammatory syndrome and neurosym

198 occal CSF clearance and a lower incidence of immune reconstitution inflammatory syndrome and relapse

199 that PML can present during the course of an immune reconstitution inflammatory syndrome and that it

200 n was inversely related to the occurrence of immune reconstitution inflammatory syndrome at the time

201 The incidence of recognized cryptococcal immune reconstitution inflammatory syndrome did not diff

202 New syndromes such as the immune reconstitution inflammatory syndrome have emerged

203 e factors associated with the development of immune reconstitution inflammatory syndrome in HIV patie

204 Immune reconstitution inflammatory syndrome occurred in

205 ptoms, 2 patients presented criteria for the immune reconstitution inflammatory syndrome of the CNS,

206 Incidence of paradoxical immune reconstitution inflammatory syndrome was 5% (two

207 The presence of immune reconstitution inflammatory syndrome was determin

208 Tuberculosis-associated immune reconstitution inflammatory syndrome was more com

209 Therefore, a murine model of PcP-related immune reconstitution inflammatory syndrome was used to

210 ed, of whom 22 (10 with clinically diagnosed immune reconstitution inflammatory syndrome) fulfilled t

211 ng to acute inflammatory responses (known as immune reconstitution inflammatory syndrome) shortly aft

212 maging and to analyse their association with immune reconstitution inflammatory syndrome, and surviva

213 e been most extensively updated are those on immune reconstitution inflammatory syndrome, tuberculosi

214 treated rabies, indicative of a neurological immune reconstitution inflammatory syndrome.

215 itive predictive value of 88% for absence of immune reconstitution inflammatory syndrome.

216 ly after ART initiation, possibly because of immune reconstitution inflammatory syndrome.

217 nitiation and the clinical predictors of TBM immune reconstitution inflammatory syndrome.

218 nce for Kaposi sarcoma as a manifestation of immune reconstitution inflammatory syndrome.

219 ns from antiretroviral drug toxicity and the immune reconstitution inflammatory syndrome.

220 une pathology, without clinically recognized immune reconstitution inflammatory syndrome.

221 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome.

222 asked cases, which we define as "unmasked TB-immune reconstitution inflammatory syndrome." With more

223 the compartmentalisation (or CSF escape) and immune reconstitution inflammatory syndromes.

224 was discontinued, changes consistent with an immune-reconstitution inflammatory syndrome developed.

225 T-cell immune reconstitution (IR) after allogeneic hematopoieti

226 Successful immune reconstitution (IR) is associated with improved o

227 Timely immune reconstitution (IR) is suggested to prevent VR.

228 The pulmonary host response during immune reconstitution (IR)-mediated clearance of PcP in

229 onclude that the evaluation of the antiviral immune reconstitution is a promising and appealing syste

230 tation are also at risk during the time when immune reconstitution is incomplete or while they are re

231 tion antiretroviral therapy, suggesting that immune reconstitution is not complete until the CD4 incr

232 tive conditioning, although the mechanism of immune reconstitution is unclear.

233 However, it also delays immune reconstitution, leading to frequent infections an

234 ansplant is, however, complicated by delayed immune reconstitution, leading to increased risks of fat

235 of disease, control of GVHD, enhancement of immune reconstitution, less toxic regimens, and preventi

236 vasculopathy may manifest as a result of an immune reconstitution-like syndrome after starting ART.

237 antiretroviral therapy (ART), suggesting an immune reconstitution-like syndrome.

238 In an immune reconstitution model, adoptive transfer of Gr-1+C

239 ll depletion might contribute to the delayed immune reconstitution observed after unrelated umbilical

240 Immune reconstitution occurred equivalently in chimeras

241 Immune reconstitution of autologous hematopoietic stem-c

242 could be involved in the incomplete mucosal immune reconstitution of cART-treated HIV-infected indiv

243 Immune reconstitution of CD4Treg, CD4Tcon, and CD8 T cel

244 Immune reconstitution of CMV-specific CTLs (CMV-CTLs) is

245 and evaluation of novel approaches aimed at immune reconstitution of human gut-associated lymphoid t

246 lymphoid hosts, an approach that allowed the immune reconstitution of nonpermissive mice following in

247 Following immune reconstitution of this novel strain with HSCs fro

248 We have studied the immune reconstitution of Vdelta2negative (Vdelta2neg) ga

249 Long-term immune reconstitution on antiretroviral therapy (ART) ha

250 s, emphasizing the critical impact of robust immune reconstitution on efficient control of viral infe

251 in peripheral blood without impairing early immune reconstitution or increasing risk for infections.

252 Maternal immune reconstitution or lowering breast milk CMV levels

253 pplicable cell therapy for promoting GVL and immune reconstitution, particularly in MHC-mismatched ha

254 blood transplantation (UCBT) is the delay in immune reconstitution, placing patients at increased ris

255 During immune reconstitution post-transplantation we observed s

256 V) specific cytotoxic T lymphocytes (CTL) as immune reconstitution postallogeneic transplant in a pha

257 , the presence of Tregs during the period of immune reconstitution preserves optimal TCR diversity an

258 y and their low absolute numbers also delays immune reconstitution, producing higher infection-relate

259 Despite the immune reconstitution promoted by combined antiretrovira

260 The mechanism of immune reconstitution reactions is complex and variable,

261 However, delayed immune reconstitution remains a great challenge.

262 er, how these genetic variants impact T cell immune reconstitution remains poorly understood.

263 pulated grafts, but its effect on subsequent immune reconstitution remains undetermined.

264 are consistent with delayed and insufficient immune reconstitution resulting in high infection-relate

265 sence of Foxp3(+) Tregs during the period of immune reconstitution results in the development of TCR

266 After immune reconstitution, some of these cases may show long

267 mmunosuppression influence the occurrence of immune reconstitution syndrome (IRS) in solid organ tran

268 cribes the association of allograft loss and immune reconstitution syndrome (IRS) in the course of Cr

269 New onset CNS lesions may represent immune reconstitution syndrome and seemed to be associat

270 Because immune reconstitution syndrome may occur in HIV-infected

271 Two possible mechanisms include (1) an immune reconstitution syndrome, supported by stereotypic

272 ntuberculous mycobacteria, old PTB scar, and immune reconstitution syndrome.

273 ion and treatment of Cryptococcus-associated immune reconstitution syndrome.

274 ter diagnosis and fulfilled the criteria for immune reconstitution syndrome.

275 ation, 52% met the criteria for tuberculosis immune reconstitution syndrome.

276 atients fulfilling criteria for tuberculosis immune reconstitution syndrome; liver biopsy remains a u

277 these functions may also play a role in some immune reconstitution syndromes observed during initiati

278 , once considered fatal, is now managed with immune reconstitution therapy; however, surviving patien

279 The goal of this study was to understand how immune reconstitution through antiretroviral therapy (AR

280 blishing a molecular diagnosis enables early immune reconstitution through prompt therapeutic interve

281 affected infants through their diagnosis and immune reconstitution was 87% (45/52), 92% (45/49) for i

282 tive expansion of donor-derived lymphocytes; immune reconstitution was by endogenous, host-derived AD

283 This poor immune reconstitution was characterised by a low influen

284 The pattern of immune reconstitution was characterized by heterogeneous

285 Immune reconstitution was comparable in both groups, how

286 Immune reconstitution was demonstrated by normalization

287 Enhanced functional immune reconstitution was demonstrated in CD62L(-) T-cel

288 Immune reconstitution was highly predictive of outcome f

289 xicity, activity and the impact of rhIL-7 on immune reconstitution were monitored.

290 is simple to apply, has potential to improve immune reconstitution while limiting alloreactivity afte

291 ufficiently diverse TCR repertoire to permit immune reconstitution with antiretroviral therapy alone,

292 both of which deplete naive T cells to limit immune reconstitution with antiretroviral treatment.

293 idal amphotericin-based regimens, and prompt immune reconstitution with ART are priorities for improv

294 Despite immune reconstitution with combination antiretroviral th

295 apidly converted, and there was preferential immune reconstitution with donor CD4(+) Th2 and Th1 cell

296 rst-line treatment regimens results in rapid immune reconstitution with residual low-level microbial

297 oidentical donor T cells, resulting in rapid immune reconstitution with very few viral infections.

298 Despite the immune-reconstitution with antiretroviral therapy (ART),

299 establish a strategy for augmenting GVL and immune reconstitution without elaborate T-cell manipulat

300 ubsets with defined trafficking patterns for immune reconstitution without the risk of GVHD.