ライフサイエンスコーパス: immune regulation

1 at these cells are 'multitalented masters of immune regulation'.

2 ast (OC) cell fusion, as well as DC-mediated immune regulation.

3 re responsible for various aspects of T-cell immune regulation.

4 in lipid metabolism, cellular signaling and immune regulation.

5 lation may impact multiple players in innate immune regulation.

6 as butyrate, which affect DNA integrity and immune regulation.

7 mplicated in both apoptotic cell removal and immune regulation.

8 c oxide synthase (iNOS) produced by MDSCs in immune regulation.

9 t understanding of the functions of GATA3 in immune regulation.

10 was shifted toward immune activation versus immune regulation.

11 gly shown that the lungs are a major site of immune regulation.

12 on, and plays roles in tissue remodeling and immune regulation.

13 iR-155) one of the first to be implicated in immune regulation.

14 heralded a major shift in T-cell biology and immune regulation.

15 he beta-lactam hapten and/or an imbalance in immune regulation.

16 ubjects them to prolonged states of negative immune regulation.

17 phasis on recent developments in the area of immune regulation.

18 es for high- and low-affinity iNKT clones in immune regulation.

19 helial barrier disruption and alterations in immune regulation.

20 and MMPs/TIMPs may be involved in the local immune regulation.

21 ritic cells (DCs) are important mediators in immune regulation.

22 as enhanced in the absence of IL-10-mediated immune regulation.

23 and intermittent diarrhea suggested impaired immune regulation.

24 indicating the significant role of Tregs in immune regulation.

25 , thus revealing a novel mechanism for local immune regulation.

26 to LC motility/migration and LC migration to immune regulation.

27 me with previously defined roles in adaptive immune regulation.

28 eptibility genes that control key aspects of immune regulation.

29 s an important role in bacterial killing and immune regulation.

30 ession may be attributable to dysfunction of immune regulation.

31 ouse bacterial load, suggesting some role in immune regulation.

32 as a mechanism of regulatory T cell-mediated immune regulation.

33 icating a potential role for this pathway in immune regulation.

34 by epithelial barrier disruption and altered immune regulation.

35 se that is also linked to both metabolic and immune regulation.

36 sis, tissue development, carcinogenesis, and immune regulation.

37 function of B7-H3, B7x, HHLA2, and TMIGD2 in immune regulation.

38 mmensal microbiota, the IL-23/Th17 axis, and immune regulation.

39 metabolic physiological processes, including immune regulation.

40 lays an important role in several aspects of immune regulation.

41 e with proteinase 3 ANCA, suggesting greater immune regulation.

42 TGF-beta plays a crucial role in immune regulation.

43 ification of potentially novel mechanisms of immune regulation.

44 A axis in controlling energy homeostasis and immune regulation.

45 s of cell communication that are critical in immune regulation.

46 many of the induced proteins are involved in immune regulation.

47 cytes that have been shown to be involved in immune regulation.

48 properties that affect T cell activation and immune regulation.

49 e in axon guidance, vascular patterning, and immune regulation.

50 T-cells (Tregs) have catalyzed the field of immune regulation.

51 animal models suggest a role for polySia in immune regulation.

52 mportant role of miRNAs in estrogen-mediated immune regulation.

53 y T cells (CD25(+) Tregs) play a key role in immune regulation.

54 for the pathogenesis of atopic diseases and immune regulation.

55 s therefore identified as a major new hub of immune regulation.

56 iology, host defense against infections, and immune regulation.

57 ing evidence supports a role for exosomes in immune regulation.

58 substantial barrier to the understanding of immune regulation.

59 y infection affects the long-term quality of immune regulation.

60 ation, smooth muscle cell proliferation, and immune regulation.

61 g light on unappreciated mechanisms of neuro-immune regulation.

62 genetic diseases that reveal new concepts of immune regulation.

63 pies for MS patients that promote heightened immune regulation.

64 ed, which participates in several aspects of immune regulation.

65 s a cell surface death receptor critical for immune regulation.

66 ed for the gas exchange and is important for immune regulation.

67 n immunity, ranging from pathogen killing to immune regulation.

68 is due to the absence of negative control by immune regulation.

69 ative contribution of these two cytokines in immune regulation.

70 ve on the discovery of DCs and their role in immune regulation.

71 1 and promote antibody-mediated immunity and immune regulation.

72 m for autoimmune progression and escape from immune regulation.

73 ) have been recognized as central players in immune regulation.

74 IL-18 axis is critical to H. pylori-specific immune regulation.

75 ning targets downstream of mTOR that promote immune regulation.

76 n molecules (SLAMs) play an integral role in immune regulation.

77 inflammatory equilibrium critical to innate immune regulation.

78 tance of TDP-43-mediated InSAC biogenesis in immune regulation.

79 on, contributing to failure of Treg-mediated immune regulation.

80 (androgen/AR) play significant roles in both immune regulations.

81 PTDM is associated with altered immune regulation after HSCT and could represent a targe

82 idermal growth factor receptor signaling and immune regulation, among others, also displayed associat

83 (MSCs) have been suggested to participate in immune regulation and airway repair/remodeling.

84 ds raises the risk of RLB-associated loss of immune regulation and an increased risk of immune inflam

85 beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense, is a target

86 is study was to better understand the innate immune regulation and associated IFN- and transforming g

87 Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development.

88 ations for neurogenesis, dopamine signaling, immune regulation and behavior.

89 y cells provides an avenue for understanding immune regulation and biologic processes linked to intes

90 hat TLR9 and MyD88 play central roles in the immune regulation and development of protective immunity

91 o address the contributions of RRV vCD200 to immune regulation and disease in vivo, we generated a fo

92 The CD2-CD58 interaction in immune regulation and disease pathology has provided new

93 Monocytes have been implicated in immune regulation and disease progression in patients wi

94 ing several cellular processes, most notably immune regulation and DNA repair, but also cellular prol

95 ature and provide examples of the nuances of immune regulation and dysregulation that can be targeted

96 s recent studies that implicate granzymes in immune regulation and extracellular proteolytic function

97 ce by poorly understood mechanisms, but both immune regulation and graft acceptance develop without e

98 ts with CD40L and plays an essential role in immune regulation and homeostasis.

99 , have provided new insights into aspects of immune regulation and host defense that were previously

100 gest a role for STAT6 polymorphisms in early immune regulation and implications on early atopic disea

101 -lived Klrg1(+) suppressor cells to optimize immune regulation and maintain homeostasis of the Treg c

102 I3K/AKT/mTOR pathways, and genes involved in immune regulation and metabolism) for single nucleotide

103 ulatory factors (IRFs) have crucial roles in immune regulation and oncogenesis.

104 nes provide new reagents to study flavivirus immune regulation and pathogenesis.

105 Immune regulation and phagocytosis are mechanisms for CD

106 udy reveals a new mechanism for HSC-mediated immune regulation and potentially for other conditions,

107 cells may be a biomarker for fading regional immune regulation and progression to overt diabetes.

108 nd previously unknown mechanism of antitumor immune regulation and provide new insights into our unde

109 nd previously unknown mechanism of antitumor immune regulation and provide new insights into our unde

110 s unfolds previously unidentified details of immune regulation and provides new insight into homeosta

111 inding may assist in reconstituting impaired immune regulation and restoring peripheral tolerance thr

112 onship between the specificity of peripheral immune regulation and self-nonself discrimination.

113 ed important insights into the mechanisms of immune regulation and served as a proof-of-concept for p

114 Understanding the pivotal role of RLRs in immune regulation and signaling crosstalk in antiviral i

115 T cell biology in the context of intestinal immune regulation and speculate on their potential clini

116 ant roles for the matrix microenvironment in immune regulation and suggest unique strategies for immu

117 lammatory responses and participate in local immune regulation and the tissue remodeling/repair event

118 on and maturation, and a potential target of immune regulation and therapy.

119 d NKT cells, which play an important role in immune regulation and tumor rejection.

120 ing system fulfilling important functions in immune regulation and tumor surveillance.

121 oding RNAs involved in telomere maintenance, immune regulation and tumour progression, providing deep

122 n and related genes lead to a loss of normal immune regulation and underlie hemophagocytic lymphohist

123 number of pathways, including inflammation, immune regulation, and cell-cycle control.

124 hich polymorphisms in the IL-2RA gene affect immune regulation, and consequently upon susceptibility

125 vation in vasculogenesis during development, immune regulation, and endothelial/epithelial-mesenchyma

126 idate their role in innate immune responses, immune regulation, and inflammatory diseases.

127 o modulates processes such as cell invasion, immune regulation, and microenvironment modification tha

128 , likely reflecting tradeoffs in metabolism, immune regulation, and other functions of mitochondria.

129 tor 2 (FPR2) play key roles in host defense, immune regulation, and resolution of inflammation.

130 -derived AAM have properties associated with immune regulation, and the different physiological prope

131 unctions such as host-pathogen interactions, immune regulation, and tumor evasion.

132 erse roles of Blimp-1 in lineage commitment, immune regulation, and tumorigenesis.

133 etted by genetic weaknesses in mechanisms of immune regulation; and subsequent multilineage immunopat

134 inflammatory responses and are important for immune regulation, angiogenesis, wound healing, and tiss

135 cells) are innate-like T cells important in immune regulation, antimicrobial protection, and anti-tu

136 Age-related changes in immune regulation are likely to account for the age-asso

137 to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout

138 Review will focus on the different modes of immune regulation, both direct and indirect, by EVs.

139 only point to a fundamental role for GBA in immune regulation but also suggest that GBA mutations in

140 coprotein folding, cellular homeostasis, and immune regulation but are involved in multiple disease c

141 s and their ligands play a prominent role in immune regulation but many have also been implicated in

142 any seminal insights about the mechanisms of immune regulation, but their relevance to humans has bee

143 al dietary element with antioxidant roles in immune regulation, but there is little understanding of

144 iNKT cells play important roles in immune regulation by bridging the innate and acquired im

145 Immune regulation by CD4+CD25+FoxP3+ regulatory T-cells

146 In this study, mechanisms of immune regulation by MAT vaccines in vitro and in allerg

147 EAE; our finding identifies a new aspect of immune regulation by PARPs in autoimmune CNS pathology.

148 (HSCs) may play an important role in hepatic immune regulation by producing numerous cytokines/chemok

149 shing DNA damage as a downstream mediator of immune regulation by reactive oxygen species.

150 targeting Stat3 that may underlie selective immune regulation by the AAR.

151 Immune regulation by the eye takes the form of several a

152 which suggests a role for CD8(+) T cells in immune regulation by the ICOS-B7h pathway.

153 munologists and dermatologists to understand immune regulation by UV radiation affected immunology in

154 her necessary for induction of this systemic immune regulation by UVB radiation, because ablation of

155 Mendelian analysis of disorders of immune regulation can provide insight into molecular pat

156 osis (FHL) is a life-threatening disorder of immune regulation caused by defects in lymphocyte cytoto

157 histiocytosis (HLH) is an inborn disorder of immune regulation caused by mutations affecting perforin

158 Diet also impacted immune regulation, cell cycle control/gene expression, c

159 Mice deficient in HO-1 exhibit defective immune regulation characterized by a proinflammatory phe

160 Therefore, modulating CD46-induced immune regulation could be integral to the development o

161 This new method of peripheral immune regulation could potentially contribute to develo

162 infection, environmental toxins, or impaired immune regulation, create a microenvironment that foster

163 cycle progression, glycogen metabolism, and immune regulation; deregulation is associated with disea

164 The current study shows that TGF-beta immune regulation develops 30 days posttransplant, but i

165 e that STIM1 is required for T cell-mediated immune regulation during chronic Mtb infection.

166 Better understanding of the complexities of immune regulation during HAND can improve diagnosis and

167 ook at the interplay of lipid metabolism and immune regulation during host infection.

168 ittle is known about how Tregs contribute to immune regulation during memory responses to previously

169 Hippo signaling plays a key role in adaptive immune regulation during the post-MI recovery phase.

170 i et al. (2013) expose a unique mechanism of immune regulation during viral infection, which is media

171 resentation (e.g., CD83, CD86 and CD209) and immune regulation (e.g., CD101) on circulating APCs.

172 To understand the mechanisms of immune regulation employed by the host to control this i

173 Because PI3K/AKT signaling is critical for immune regulation, Ezrin-deficient MPhis are hyperinflam

174 However, immune regulation fails to control the underlying tissue

175 thogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtype

176 periphery and cause autoimmune diseases when immune regulation goes awry.

177 -derived macrophages, suggesting that global immune regulation has a significant impact on nanopartic

178 The role of prostaglandin E2 in immune regulation has been better defined.

179 physiological mechanism of perforin-mediated immune regulation has never been demonstrated in a disea

180 encoding a functionally distinct protein for immune regulation has not been addressed.

181 The biological relevance of this feature in immune regulation has not been evaluated.

182 ype 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of m

183 Defects in immune regulation have been implicated in the pathogenes

184 ingly, the first insights into Foxo-mediated immune regulation have instead revealed direct control o

185 pproaches using nanoparticles engineered for immune regulation have yielded promising results in prec

186 entify a novel potential mechanism of innate immune regulation, help define the therapeutic window fo

187 E3 ubiquitin ligase, Roquin, is involved in immune regulation; however, its role in immunity to M. t

188 onjugation system plays an important role in immune regulation; however, the ubiquitin-specific prote

189 y initial studies on immune cell culture and immune regulation, I returned to an analysis of the path

190 expression profiles that highlight cues for immune regulation in a major pest.

191 tial progress in understanding mechanisms of immune regulation in allergy, asthma, autoimmune disease

192 ents on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune disease

193 layed type hypersensitivity assay to measure immune regulation in both the recipient antidonor and do

194 ne bound receptor (CD40) that is critical to immune regulation in colon biopsies collected from monke

195 We examined TIGIT-mediated immune regulation in different murine cancer models and

196 mechanisms of inflammatory infiltration and immune regulation in DMD.

197 derscore the roles of HCV proteins in innate immune regulation in establishing a chronic infection.

198 ng an explanation for the apparent defect in immune regulation in HO-1(-/-) mice.

199 a novel mechanism for inflammation mediated immune regulation in human cancer.

200 mechanisms of immune activation or negative immune regulation in human skin.

201 rovides a model to investigate mechanisms of immune regulation in humans, given that the disease form

202 f the current understanding of signaling and immune regulation in melanoma and implications for respo

203 Mechanistic insights into gene and immune regulation in melanoma have led to the developmen

204 We also emphasize how defining the immune regulation in metabolic tissues has broadened the

205 odulation of IL-2 receptor restores impaired immune regulation in MS by increasing the proportion of

206 Defective NK-mediated immune regulation in MS is mainly attributable to a CD4(

207 T(reg) cells as the underlying mechanism of immune regulation in MSC-mediated allograft survival.

208 This apparent loss of immune regulation in obese adipose tissue contributes to

209 e known mechanisms that underlie the loss of immune regulation in obesity-associated adipose tissue i

210 relationship between small RNA pathways and immune regulation in other organisms.

211 receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma an

212 -cell compartment as an additional defect in immune regulation in patients with chronic ITP that may

213 urther investigate the role of granzyme B in immune regulation in response to viral infections, we ch

214 ith recent studies demonstrating evidence of immune regulation in some instances.

215 new mechanism of alpha4 nAChR signaling and immune regulation in T cells, possibly accounting for th

216 ght have therapeutic potential for promoting immune regulation in the context of autoimmune disease.

217 une activation, we studied perforin-mediated immune regulation in the context of mixed chimerism usin

218 of cytotoxic immune dysfunction and aberrant immune regulation in the COPD lung that may explain both

219 ng pathogen invasion plays a central role in immune regulation in the gut.

220 5+FoxP3+ Treg cells, which may contribute to immune regulation in the liver.

221 r the role of neuroinflammation and aberrant immune regulation in the pathophysiology of AD.

222 f local Treg cell populations, also to local immune regulation in the skin.

223 Thus, immune regulation in the tumor landscape may often be dr

224 a deeper understanding of the complexity of immune regulation in the tumor microenvironment, has pro

225 nd young transgenic animals, suggesting that immune regulation in this model was not impacted by agin

226 to target RMC in situ to promote Ag-specific immune regulation in transplantation and to usher in a n

227 herapeutic targets that could restore proper immune regulation in type 1 diabetes by augmenting the I

228 to the skin draining LNs, where they induce immune regulation in vivo by activating NKT cells.

229 tive Stat6 in T cells is sufficient to alter immune regulation in vivo, we mated Stat6VT transgenic m

230 ed in HCV infection, thus providing targeted immune regulation in vivo.

231 These data reveal a mechanism of immune regulation in which CTLA-4 acts as an effector mo

232 s have identified multiple genes involved in immune regulation including BANK1, C8orf13-BLK, IL-23R,

233 TNF-alpha plays an important role in immune regulation, inflammation, and autoimmunity.

234 cognition is innate and linked to a profound immune regulation (innate apoptotic immunity [IAI]) invo

235 these results indicate that B cell-mediated immune regulation is best characterized by the cytokine

236 The impact of LAP to immune regulation is best characterized in professional

237 Immune regulation is critical for the maintenance of per

238 a variety of lymphoid cells, and its role in immune regulation is just beginning to be elucidated.

239 on of the complexity of post-transcriptional immune regulation is needed.

240 , the role of TNFRp75-dependent signaling in immune regulation is poorly defined.

241 Here, a modified model of immune regulation is proposed in which a nonspecific imm

242 however, their role in local versus systemic immune regulation is unknown.

243 lectively, our results show that CpG-induced immune regulation leads to a dampening of the host immun

244 This defect in immune regulation led to a nonspecific upregulation of e

245 These studies have revealed a new immune regulation loop consisting of T cell-derived IFN-

246 ental data in relation to the role of LAIR-1 immune regulation may be overestimated when applied to a

247 One important area where SLAM-mediated immune regulation may have keen importance is in the fie

248 We propose that immune regulation may prolong pneumococcal colonization

249 ts correlates with carcinogen resistance and immune regulation mediated by tumour-associated immune c

250 rectal cancer progression in which disrupted immune regulation, mTOR-Stat3 signaling, and epithelial

251 e intersection of two key pathways of innate immune regulation, NLR and STING, to fine tune host resp

252 OR) signaling pathway has been implicated in immune regulation, not only by suppressing T cell respon

253 se needs to be proinflammatory; and finally, immune regulation of autoreactive responses must fail.

254 As TLR2 has been implicated in immune regulation of helminth infections and as alternat

255 istic evidence supporting its role in innate immune regulation of islet-directed autoimmunity.

256 ed it as a powerful system to study adaptive immune regulation of organogenesis.

257 g metastatic spread, including evidence that immune regulation of primary tumors may be distinct from

258 These data demonstrate that the immune regulation of SerpinB2 expression plays a critica

259 schaemia; however, their contribution to the immune regulation of Th2-skewed allergic rhinitis (AR) a

260 nuclear cell subsets in parasite control and immune regulation of the CNS.

261 ated with stemness has implications for both immune regulation of tumor growth as well as regenerativ

262 TGF-beta1 is a master cytokine in immune regulation, orchestrating both pro- and anti-infl

263 /beta-catenin/Foxo1 signaling in TLR4 innate immune regulation, our study provides a rationale for th

264 pecific CD8 T cell activation, but efficient immune regulation, partially mediated by IL-10R-signalin

265 Defective immune regulation plays a permissive role enabling effec

266 or HC, suggests a possible role of HLA-G in immune regulation possibly mediated by enhanced host Tre

267 Transplacental immune regulation refers to the concept that during preg

268 mitochondrion-dependent cell death of DCs in immune regulation remain to be elucidated.

269 , the functions of IL-31-IL-31R signaling in immune regulation remain unknown.

270 rin in the maintenance of DC homeostasis for immune regulation remains to be determined.

271 The in vivo role of JKAP in immune regulation remains unclear.

272 Despite loss of detectable TGF-beta immune regulation, renal allografts continue to function

273 T cells assist in viral clearance, but immune regulation serves to limit these responses and to

274 onses, and nearly all the miRNAs involved in immune regulation show modulation during aging.

275 On the other hand, miRNAs are involved in immune regulation, such as regulatory T (Treg) cell diff

276 ptance is associated with TGF-beta-dependent immune regulation, suggesting a role for T regulatory ce

277 sion, we demonstrate a novel role for GP2 in immune regulation that could provide a platform for new

278 appaB activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiqui

279 CTL activation, functionally shape systemic immune regulation that may modify risk of inflammatory d

280 y plays a critical role in the lung-specific immune regulation that prevents spontaneous inflammation

281 to elucidate the role of SlpA in protective immune regulation, the NCK2187 strain, which solely expr

282 on, differentiation, plastic adaptation, and immune regulation, thereby mediating tumorigenesis, meta

283 n non-HCV-specific CD4 T cells suggests that immune regulation through antigen-specific Treg inductio

284 egulatory T cells (T(reg)) play key roles in immune regulation through multiple modes of suppression.

285 infection by secreting cytokines crucial for immune regulation, tissue homeostasis, and repair.

286 he maintenance of an organism's health, from immune regulation to fat metabolism.

287 controls multiple aspects of T cell-mediated immune regulation to limit injurious inflammation during

288 nonapoptotic roles of caspases ranging from immune regulation to spermatogenesis, in highly speciali

289 me B in the regulatory T cell compartment in immune regulation to viral infections.

290 f lymphocytes, which play important roles in immune regulation, tumor surveillance, and host defense

291 , we hypothesized that it modulates vascular immune regulation under homeostatic conditions and dysre

292 etic or CD8(+) T cell chimerism, above which immune regulation was reestablished.

293 Although first implicated in immune regulation, we propose that NLRX1 function extend

294 en T cells unresponsive to TGF-beta-mediated immune regulation were used as donor T lymphocytes.

295 merges as a factor with diverse functions in immune regulation, which are in some cases cell-type spe

296 disease at 1 year, and genes associated with immune regulation, which showed increased levels in pati

297 (T1D) is thought to be caused by a defective immune regulation with regulatory T (Treg) cells playing

298 e of infection depends on multiple layers of immune regulation, with innate immunity playing a decisi

299 t cellular proliferation, communication, and immune regulation within the cutaneous microenvironment.

300 tenance of antihypergesia can be achieved by immune regulation without actual engraftment of BMSCs.