ライフサイエンスコーパス: immune system

1 des a route for engagement of PLA2R with the immune system.

2 tolerant biofilms that resist killing by the immune system.

3 he TA polymers that interact with the innate immune system.

4 tities caused by dysregulation in the innate immune system.

5 elated to cell type-specific function in the immune system.

6 fications to the local and systemic maternal immune system.

7 invasion of host tissues, and evasion of the immune system.

8 latory interactions between both arms of the immune system.

9 inical studies to fruitfully interrogate the immune system.

10 ly useful effects without involvement of the immune system.

11 nase signaling with established roles in the immune system.

12 rategies to inhibit or avoid the host innate immune system.

13 an exoskeleton that has been co-opted as an immune system.

14 ts is shaped decisively by the status of the immune system.

15 ight the risk of unbridled activation of the immune system.

16 al role of the gut microbiota in shaping the immune system.

17 tions and are critical for regulation of the immune system.

18 e that affects every aspect of the mammalian immune system.

19 tant and diverse role in the function of the immune system.

20 in infancy is important in maturation of the immune system.

21 ecognition of self and non-self cells by the immune system.

22 ncers and contributes to evasion of the host immune system.

23 ed belonged to the IgM isotype of the innate immune system.

24 ce damage to an allograft by the recipient's immune system.

25 ngage in a dynamic equilibrium with the host immune system.

26 w insights into the shaping of the childhood immune system.

27 perinatal outcomes in a host with an intact immune system.

28 ells may be recognized and eliminated by the immune system.

29 er nutrient availability or evasion from the immune system.

30 home to damaged tissues and can modulate the immune system.

31 strategies to avoid their eradication by the immune system.

32 thought to be required for activation of the immune system.

33 lectively exposed in the ZAM to the maternal immune system.

34 gC4 augments bacterial clearance by the host immune system.

35 well as development and function of the host immune system.

36 nvolved in the modulation and evasion of the immune system.

37 d also a potent stimulator of the eukaryotic immune system.

38 therapy to tilt the balance in favor of the immune system.

39 d factors important for escape from the host immune system.

40 merged as important regulators of the innate immune system.

41 or reconstituted with a near-complete human immune system.

42 in response to peripheral activation of the immune system.

43 nto the logical organization of the complete immune system.

44 that plays a crucial role in cancer and the immune system.

45 utrient acquisition and priming of the plant immune system.

46 s dictated by multiples cues from the innate immune system.

47 ted with several abnormalities of the innate immune system.

48 tory process initiated by lymphocytes of the immune system.

49 ucosa without being rejected by the maternal immune system.

50 lular responses, particularly throughout the immune system.

51 pioid receptors, and T cells of the adaptive immune system.

52 are crucial viral sensors in the host innate immune system.

53 ptors (TLRs) are major players of the innate immune system.

54 e involved in entry and targeted by the host immune system.

55 ist in maintaining homeostasis of the animal immune system.

56 re easily accessible and recognizable by the immune system.

57 urface molecules that signal to cells of the immune system.

58 ate growth and differentiation events in the immune system.

59 this bacterium is normally tolerated by the immune system.

60 typically disposed of without activating the immune system.

61 t cancer cells can exploit to circumvent the immune system.

62 ritical regulators of gene expression in the immune system.

63 ary relationship between innate and adaptive immune systems.

64 gulation by bridging the innate and acquired immune systems.

65 tem cells that develop into functional human immune systems.

66 ogical function, including the endocrine and immune systems.

67 portant role in both the innate and adaptive immune systems.

68 integration of the circadian, metabolic, and immune systems.

69 rmonal signaling is important for regulating immune system activity and, more generally, for governin

70 uto-antibodies produced by the patient's own immune system after exposure to cancer proteins are prom

71 d profound activation of cells of the innate immune system after food challenge, including monocytes,

72 notherapies that harness the activity of the immune system against tumors are proving to be an effect

73 ents the cancer from being eliminated by the immune system and allows disease to progress from a very

74 phages represent critical arms of the innate immune system and are considered regulators and effector

75 The interactions between the immune system and cancer cells are continuous, dynamic,

76 both initiate and sustain activation of the immune system and cause vascular changes associated with

77 the anti-CCR4 antibody required the adaptive immune system and CD4+ T cells.

78 al life is a key time for development of the immune system and colonization of the host by microbiota

79 are essential components of the host innate immune system and define first-line of defence against p

80 mostly genes related to glucose metabolism, immune system and development were differentially expres

81 m the microbiome that educates the mammalian immune system and enhances nutrition to relationships th

82 a is accompanied by activation of the innate immune system and involves inflammasome-dependent format

83 regulatory T cells (Treg cells) modulate the immune system and maintain self-tolerance, but whether t

84 at guide the maintenance and function of the immune system and on lymphoid organs that coordinate bot

85 on hepatic and neuronal regions, leaving the immune system and specifically monocyte-derived dendriti

86 The growth and maturity of the peripheral immune system and subsequent development of pulmonary im

87 of interaction and communication between the immune system and the nervous system.

88 It can also take advantage of the developing immune system and the not-yet-stabilized gut microbiota

89 tra-cellular signaling proteins of the human immune system and their response to several perturbation

90 eries of age-related changes that affect the immune system and, with time, lead to increased vulnerab

91 ons for understanding the complexity of host immune systems and the diverse functions of noncoding RN

92 NK cells are part of the innate immune system, and are able to identify and kill hazardo

93 an emphasis on the viral evasion of the host immune system, and discusses how to harness the immune s

94 a pattern recognition molecule of the innate immune system, and evidence suggests that it modulates d

95 molecular pattern recognition by the innate immune system, and how this may influence adaptive immun

96 ote the signalling of senescent cells to the immune system, and it may contribute to chronic inflamma

97 r extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implicati

98 The relevance of the innate immune system, and monocytes in particular, has emerged

99 fic way, operating in neuronal response, the immune system, and stress response.

100 tweight and virtually invisible to the human immune system, and they thus have revolutionary potentia

101 ng between the intestinal microbiota and the immune system, and we will discuss how a dietary-induced

102 tor NF-kappaB plays an important role in the immune system, apoptosis and inflammation.

103 le for T. denticola activation of the innate immune system are currently not well defined.

104 Accordingly, both the gut microbiota and immune system are implicated in the etiopathogenesis or

105 atory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated

106 f the interactions between components of the immune system as well as the overwhelming amounts of dat

107 l for normal development and function of the immune system, as evidenced by the severe immune abnorma

108 t direct suppressive effects on the adaptive immune system, as serum from stroke patients inhibited t

109 ells (B10 cells) play a critical role in the immune system balance by negatively regulating inflammat

110 Thus, by acting as a fine switch in the immune system, BiG emphasizes the differential roles of

111 n the target tissue (cholangiocytes) and the immune system (bone marrow).

112 been assumed to be due to immaturity of the immune system, but the mechanism remains unclear.

113 tablish infection and avoid clearance by the immune system by mechanisms that are not well understood

114 uss the role of early-life regulation of the immune system by the microbiota and how it can be relate

115 e demonstrate that TCP14 regulates the plant immune system by transcriptionally repressing a subset o

116 bial metabolites in the function of the host immune system by which they influence disease processes

117 ary from activating different subsets of the immune system, by controlling transcriptional activators

118 ances in immuno-oncology have shown that the immune system can be activated to induce long-term, dura

119 idins provide a novel mechanism by which the immune system can discriminate between viable and nonvia

120 mplify the creative solutions that the human immune system can evolve to recognize a conserved motif

121 The immune system can mount T cell responses against tumors;

122 However, growing evidence suggests that the immune system can play surprising roles in sodium homeos

123 study two different mechanisms by which the immune system can select for broadly neutralizing capaci

124 uingly, our data support a notion that plant immune systems can respond to pathogenic ncRNAs, which h

125 Animal immune systems change dramatically during the ageing pro

126 ticular challenge for pathogens are external immune systems, chemical defence systems comprised of po

127 The plant innate immune system contains a limited NLR repertoire that fun

128 ticle, we tested whether the platelet innate immune system contributes to responses to oxPCCD36 and a

129 er understanding of how multiple arms of the immune system cooperate to achieve an optimal antiviral

130 The complexity of the immune system creates challenges in exploring its import

131 asite maturation represents a host-mediated, immune system-dependent mechanism for limiting parasite

132 Immune system-derived cytokines stimulate the hypothalam

133 nderlie enteric symbiont-stimulated systemic immune system development, and indicate that these proce

134 Bd because the early-life microbiota, during immune system development, predicted later-life infectio

135 r childhood psychosocial stressors to affect immune system development, which in turn can affect brai

136 ization and physiology, and suggest that the immune system distributes its TCR sequences unevenly, at

137 ytes plays a major role in tumor escape from immune system during cancer progression.

138 could provide antigens for activation of the immune system during the allergic response.

139 une system, and discusses how to harness the immune system effectively as a therapeutic tool in selec

140 dy state, while the presence of the adaptive immune system elevates their activation state.

141 tions provide novel evidence that the innate immune system employs protective mechanisms aimed at mit

142 omotes competent innate and acquired mucosal immune systems, epithelial renewal, barrier integrity, a

143 recognition of encapsulated allergen by the immune system, especially by IgE antibodies, is prevente

144 It has become apparent that the immune system evolved multiple mechanisms for controllin

145 The immune system focuses on and responds to very few repres

146 known function with potential effects on the immune system, followed by breeding to homozygosity and

147 plex microbial management role of the innate immune system for controlled accommodation of beneficial

148 ethods now allow us to interrogate the human immune system for multiple markers of inflammation at a

149 Immune tolerance is necessary to prevent the immune system from reacting against self, and thus to av

150 Defective immune system function is implicated in autism spectrum

151 How plants merge immune system function with normal growth and developmen

152 rget for cell therapies to restore effective immune system function.

153 ) that play important roles in digestive and immune system functioning, yet cetacean microbiomes rema

154 have broadened our comprehension of how the immune system functions in the brain and can readily ove

155 CLO showed stronger effects on immune system genes than cortisol, which was characteriz

156 type block and the expression pattern of key immune system genes.

157 otypes and identify 5 novel loci enriched in immune system genes.

158 contrast, flies with a constitutively active immune system had microbiota readily distinguishable fro

159 astrointestinal tract and associated mucosal immune system harbor a large repertoire of metabolites o

160 larly interspaced short palindromic repeats) immune system has been adapted for genome-scale screenin

161 The bacterial CRISPR-Cas9 immune system has been harnessed as a powerful and versa

162 The mammalian immune system has evolved over many millennia to be best

163 The functional relevance of the innate immune system has not yet been dissected in P0106-125-in

164 cell interactions in different areas of the immune system has offered an unprecedented opportunity t

165 The innate immune system has recently been shown to promote tissue

166 Historically, only cells of the adaptive immune system have been considered capable of retaining

167 Recently, however, cells of the innate immune system have been shown to be capable of displayin

168 n the role that both stress and an activated immune system have in neuropathology, innate immune trai

169 ecially their interplay with the host innate immune system, have not been well investigated.

170 ind placebo-controlled crossover design, the immune system in 22 sample donors was transiently activa

171 etic approach to investigate the role of the immune system in a large sample of post-mortem brain of

172 g evidence implicating a role for the innate immune system in AD initiation and progression.

173 d to manipulate individual components of the immune system in an in vivo environment.

174 ome-editing system is a part of the adaptive immune system in archaea and bacteria to defend against

175 urvival and the ability to escape the innate immune system in blood.

176 gulation of various components of the innate immune system in both diseases, including inflammasome a

177 lammatory signaling molecules and the innate immune system in directing brain masculinization, the ev

178 ne the activation of the innate and adaptive immune system in obesity; inflammation within diabetic i

179 s, resulting in a fundamentally restructured immune system in older individuals.

180 hlight the roles of p53, senescence, and the immune system in preventing the outgrowth of aneuploid c

181 he roles of specific components of the human immune system in protection from S. aureus infection.

182 The type I-F CRISPR adaptive immune system in Pseudomonas aeruginosa (PA14) consists

183 The adaptive immune system in Pseudomonas aeruginosa (type I-F) relie

184 infection of pathogens, and guiding the host immune system in response to foreign invasions.

185 The role of the immune system in schizophrenia remains controversial des

186 cuss the role and mechanisms of the maternal immune system in simultaneously mediating maternal-fetal

187 s a compelling case for considering the host immune system in studies of restriction factor mechanism

188 important, yet poorly defined, role for the immune system in the development of secondary neurologic

189 role of scavenger receptor function and the immune system in the development of this age-related dis

190 Analysis of the immune system in the kidney relies predominantly on flow

191 Involvement of the immune system in tumour progression is at the forefront

192 ese clinical findings suggest a role for the immune system in vulnerability to stress-related psychia

193 robial peptides are components of the innate immune systems in animals and plants as natural defense

194 iological function of CRISPR-Cas as adaptive immune systems in bacteria.

195 tunities for understanding the complexity of immune systems in differentiating "self" and "nonself,"

196 ted (cas) genes make up RNA-guided, adaptive immune systems in prokaryotes whose effector proteins ha

197 Gut microbiota and the immune system interact to maintain tissue homeostasis, b

198 complement are key components of the innate immune system involved in the opsonization, phagocytosis

199 parasite Trypanosoma brucei against the host immune system is a dense coat that comprises a variant s

200 he dialog between nociceptor neurons and the immune system is a fundamental aspect of inflammation, b

201 Activation of cells in the adaptive immune system is a highly orchestrated process dictated

202 The innate immune system is activated in a number of degenerative a

203 A central element of this immune system is an RNA-guided surveillance complex capa

204 The immune system is composed of diverse cell types that coo

205 development of the human microbiome and the immune system is important to enable the development of

206 echanism, the regulatory architecture of the immune system is likely to include the added dimensions

207 endocrine disrupting chemicals (EDCs) on the immune system is unclear.

208 The immune system is under circadian influence; time-of-day

209 The sooner the immune system launches, the greater the chances the host

210 hils are multifunctional cells of the innate immune system linked to allergic inflammation.

211 wo-way interaction between the brain and the immune system makes it possible for childhood psychosoci

212 The gut microbiome in infancy influences immune system maturation, and may have an important impa

213 , in combination with their abundance in the immune system, may have a significant role in regulating

214 Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes.

215 cellular matrix (ECM), lipid, cell survival, immune system, metabolism, or unknown/other pathway.

216 As sentinels for the immune system, MG also detect "danger" signals (pathogen

217 The host's mucosal immune system must tolerate commensals while fighting pa

218 ood are essential for establishing an active immune system necessary to prevent disease later in life

219 creased exposure of beta-(1,3)-glucan to the immune system occurs when the mannan layer is altered or

220 lex (MHC) is a key component of the adaptive immune system of all vertebrates and consists of the mos

221 ectly, taking advantage of the many ways the immune system of humans can be manipulated.

222 nteraction mechanism of destruxin A with the immune system of P. xylostella at genomic level is still

223 The innate immune system of patients with Alzheimer's disease and m

224 The innate immune system of plants recognizes microbial pathogens a

225 Unexpected findings from the immune system of sea urchin larvae potentially provide i

226 The immune system of vertebrate species consists of many dif

227 bind, conferred a selective advantage in the immune systems of infected hosts to recall of memory B c

228 t of aging on cells of the (mostly adaptive) immune system, on soluble molecules that guide the maint

229 autoimmune complications driven by adaptive immune system overactivation, and that CD163 is key medi

230 The results from trials targeting these immune system pathways have provided important lessons f

231 by breeding to homozygosity and testing for immune system phenotypes.

232 an increased risk for diseases in which the immune system plays a critical role.

233 of native PvRBPs, suggesting that the human immune system produced functional binding-inhibitory ant

234 n less effective in songbirds, likely due to immune system properties.

235 ent studies are supporting the idea that the immune system provides support for the nervous system at

236 re critical components of the human adaptive immune system, providing versatile scaffolds to display

237 garding the mechanism by which the mammalian immune system recognizes these viruses.

238 Here it is not clear how the immune system reconciles receptor binding of self-protei

239 The development of the tsetse fly immune system relies on a cue from an endosymbiotic bact

240 since how conventional treatments impact on immune system remains unclear, proper integration is sti

241 unodeficient mice reconstituted with a human immune system represent a promising tool for translation

242 teric microbiota and the innate and adaptive immune system represent prime candidates that impact on

243 BACKGROUND & AIMS: The innate immune system responds not only to bacterial signals, bu

244 yndrome associated with a maladaptive innate immune system response that leads to deleterious cardiac

245 coprotein related to virus invasion and host immune system response.

246 ics and smoking play important roles in host immune system response.

247 ve damage to host tissues and evasion of the immune system response; they are major contributors to m

248 epth systems analysis of innate and adaptive immune system responses to implanted biomaterials in rod

249 In contrast, necroptotic cells alert the immune system, resulting in inflammation and tissue dama

250 d cells (ILCs) have an important role in the immune system's response to different forms of infectiou

251 d virus determines the initial damage to the immune system, setting the pace for later disease progre

252 nst enzymatic attack through the host innate immune system, such as the cell wall hydrolase lysozyme.

253 c leukemia (ALL), and the involvement of the immune system suggests that vaccination may also play a

254 re tissue-resident "first responders" of the immune system that function to protect epithelial barrie

255 ukocyte migration is a crucial issue for the immune system that is mainly organized through the activ

256 c4e), a C-type lectin receptor of the innate immune system that is strongly up-regulated in response

257 NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and localiz

258 pattern-recognition receptors of the innate immune system that sense pathogen-derived nucleic acids.

259 interaction between lentiviruses and primate immune systems that may contribute to pathogenesis.

260 CRISPR-Cas are prokaryotic adaptive immune systems that provide protection against bacteriop

261 PR-Cas systems in prokaryotes are RNA-guided immune systems that target and deactivate foreign nuclei

262 biological processes, including the adaptive immune system, the development of neoplasms, and the per

263 ns have been extensively investigated in the immune system, their role in cancer progression remains

264 arms race between viral suppressors and the immune system they target.

265 ated that T. denticola stimulates the innate immune system through Toll-like receptor 2 (TLR2); howev

266 EM2 in regulating the response of the innate immune system to Abeta pathology.

267 ancements that enable broad profiling of the immune system to better understand the response to infec

268 a large panel of irrelevant antigens to the immune system to block or misdirect protective responses

269 immune mechanisms, while others harness the immune system to clear deleterious products and cells.

270 One of the mechanisms used by the mucosal immune system to maintain homeostasis is the secretion o

271 odeficiency" is the inability of the encoded immune system to protect an otherwise healthy host from

272 t process in haematopoiesis, which forms the immune system to protect the host from pathogen invasion

273 int blockade immunotherapies enable the host immune system to recognize and destroy tumour cells.

274 rests in usurping the power of the patient's immune system to recognize and eliminate GBM.

275 eucine-rich repeat (NLR) proteins enable the immune system to recognize and respond to pathogen attac

276 n, and release neuropeptides that act on the immune system to regulate inflammation.

277 The ability of the adaptive immune system to respond to arbitrary pathogens stems fr

278 y concentrate on adjuvants that modulate the immune system to support enhanced TH1 responses and decr

279 teraction depends on the ability of the host immune system to suppress viral replication and the abil

280 native therapeutic approach that teaches the immune system to tolerate contact allergens by expanding

281 Harnessing immune system to treat cancer requires simultaneous gene

282 of a vomeronasal Fpr can reverse back to the immune system under inflammatory conditions via the prod

283 ify and characterise individual cells of the immune system under label-free conditions would be a sig

284 veals a conversation between the nervous and immune systems using distinct receptors.

285 othesized that an assessment of the adaptive immune system, using CD4+ T-lymphocyte transcriptomics,

286 o detect potential infections, the mammalian immune system utilizes several families of pattern recog

287 The immune system varies in cell types, states, and location

288 hese data suggest that the activation of the immune system via peripheral endotoxin increases neurona

289 al peptides that play a vital role in insect immune system was up-regulated after the injection of de

290 However, they are also found in cells of the immune system, where their role has been less studied.

291 ew will consider the aspects of the neonatal immune system which might contribute to the development

292 ne such factor involves dysregulation of the immune system, which has been linked to the pathophysiol

293 ggest altered development of the offspring's immune system, which in turn results in dysregulated fun

294 a recent discovery of the adaptive bacterial immune system, which is based on clustered regularly int

295 these dead cells falls on phagocytes of the immune system, which surveil their surroundings for dyin

296 tes interacting with the innate and adaptive immune system, which would set the basis for preventativ

297 mentally caused by replacement of the host's immune system with donor cells, although the heterogenei

298 taneum, which has a well-documented external immune system with strong inhibitory effects against B.

299 nces 1024 Plants have evolved a multilayered immune system with well-orchestrated defense strategies

300 lude autonomic, neuroendocrine, enteric, and immune systems, with pathology resulting in disruption t