ライフサイエンスコーパス: immune-privileged

1 r MSCs suggest that MSCs may not actually be immune privileged.

2 protective effects, and are considered to be immune privileged.

3 brain parenchyma, a site that is considered immune privileged.

4 cells derived from autologous iPSCs will be immune-privileged.

5 Fetal tissue is considered to be immune privileged and is under extensive investigation a

6 oscientists, we are taught that the brain is immune privileged and thus unlikely to be affected by th

7 topically, forms the anterior surface of the immune privileged anterior chamber.

8 The cornea is an immune privileged barrier tissue that relies primarily o

9 neurons in the healthy brain were considered immune-privileged because they did not appear to express

10 their multipotent differentiation, and their immune-privileged behavior, reveals, at least in part, t

11 Neonates are not immune privileged but generate TH2 or TH1 responses, dep

12 of Fas ligand (FasL) renders certain tissues immune privileged, but its expression in other tissues c

13 Neonatal porcine Sertoli cells (NPSC) are immune privileged cells showing innate phagocytic and an

14 PI-9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protects these c

15 plore the tumor-specific CTL response in the immune-privileged central nervous system using P511 mast

16 Vigorous immune responses are induced in the immune privileged CNS by injury and disease, but the mol

17 d function of NK cells in the traditionally "immune-privileged" CNS is controversial.

18 In the immune-privileged cornea, epithelial wounds heal rapidly

19 transient progeny virion replication in the immune-privileged cornea.

20 LX are highly expressed in the avascular and immune-privileged cornea.

21 ese data refute the tenet that the cornea is immune privileged due to lack of resident lymphoreticula

22 d for latent pathogens and persistence in an immune-privileged enteric niche.

23 al cells contributes to the generation of an immune-privileged environment at the maternal-fetal inte

24 d SCID mice, could survive in the relatively immune-privileged environment of dialysis membrane chamb

25 Our data demonstrate that the immune-privileged environment within the eye induces a t

26 Although intraocular tumors reside in an immune-privileged environment, T cells can circumvent im

27 The CNS is an immune-privileged environment, yet the local control of

28 tion that guide migration of T cells in this immune-privileged environment.

29 ve expression of FasL and hence maintain an "immune privileged" environment within the testicle.

30 ta2-treated Ag-pulsed APC mimic APC from the immune privileged eye, and provide signals that generate

31 required to initiate inflammation within the immune privileged eye, as compared with nonprivileged si

32 om primary uveal melanomas that arise in the immune-privileged eye, prime and boost IFNgamma-secretin

33 We previously showed that, within the immune-privileged eye, tumors expressing high levels of

34 cognate antigens are sequestered within the immune-privileged eye.

35 However, GCs are considered to be immune privileged for antiviral CD8 T cells.

36 ration of tumor antigens within a relatively immune privileged location present serious problems for

37 wn that it is very difficult to abrogate the immune privileged mechanism called anterior chamber-asso

38 ery few events are capable of overcoming the immune-privileged mechanisms in the eye.

39 nt, as well as potentially contribute to the immune-privileged nature of the brain.

40 ring maturation that could contribute to the immune-privileged nature of the CNS or potentially influ

41 rowth, played a key role in formation of the immune-privileged niche, and predicted poor prognosis in

42 Human uveal melanoma arises in an immune privileged ocular environment in which both adapt

43 fective immune modulation in the classically immune-privileged ocular haven.

44 AP-1 in the recruitment of leukocytes to the immune-privileged ocular tissues during acute inflammati

45 We now know that the brain is not an immune privileged organ.

46 The liver is considered to be an immune-privileged organ that favors the induction of tol

47 The brain, previously thought of as an immune-privileged organ, is now known to communicate ext

48 Although the inner ear has been known as an immune-privileged organ, there is emerging evidence indi

49 Despite being considered an immune-privileged organ, we detect a mycobacteria-specif

50 nfected macrophages or if ranavirus exploits immune privileged organs, such as the brain, in order to

51 s ligand (CD95L) inhibits T cell function in immune-privileged organs such as the eye and testis, yet

52 clear placental viral infections within the immune-privileged placenta.

53 wo factors, their low immunogenicity and the immune-privileged properties of the eye.

54 controversy remains as to whether hESCs have immune-privileged properties.

55 e photoreceptors and synaptic regions of the immune-privileged retina implies a role in visual transm

56 The CNS is considered an immune privileged site because its repertoire of highly

57 One clinical example of the function of an immune privileged site is the success of human corneal t

58 The lens has been considered to be an immune privileged site not susceptible to the immune pro

59 The eye is an immune privileged site that is styled to maintain the vi

60 esence of parenchymal cells from the eye (an immune privileged site) express B7-2 in a manner that eq

61 Although once believed to be an immune privileged site, it is now known that antimicrobi

62 Although intraocular tumors reside in an immune privileged site, some tumors are rejected nonethe

63 or this molecule in tumor surveillance in an immune privileged site.

64 sult implies that the subretinal space is an immune-privileged site and a favorable site for gene tra

65 notherapy because primary tumors arise in an immune-privileged site and may express antigens to which

66 Immune-privileged site DLBCL (IP-DLBCL) patients reporte

67 e barriers in the mammalian body, creates an immune-privileged site for postmeiotic spermatid develop

68 ted cells that line the subretinal space, an immune-privileged site in the eye.

69 nt infection in the seminiferous tubules, an immune-privileged site in the testis protected by the bl

70 ined the fate of such grafts placed in a non-immune-privileged site of adult recipient mice.

71 ent of systemic tolerance associated with an immune-privileged site suggests a mechanism involving NK

72 cades the brain has been considered to be an immune-privileged site that excludes circulating cells f

73 Although intraocular tumors reside in an immune-privileged site where immune responses are suppre

74 The central nervous system (CNS) is an immune-privileged site where the role of immune cells an

75 tudy documents that tumors growing within an immune-privileged site within the eye develop a tumor es

76 The eye is an immune-privileged site, and FasL expression is a major p

77 n be elicited by introducing antigen into an immune-privileged site, such as the eye, or directly int

78 As an immune-privileged site, the eye, and particularly the ou

79 Therefore, this model for immune-privileged site-mediated tolerance provided us wi

80 s lining the anterior chamber of the eye, an immune-privileged site.

81 across the BTB to exert their effects at the immune-privileged site.

82 duced by the introduction of antigen into an immune-privileged site.

83 body PE, and retina PE of the inner eye, an immune-privileged site.

84 tissue as to the qualities of the eye as an immune-privileged site.

85 f the PD-1:PD-L1 interaction in creating an "immune-privileged" site for initial viral infection and

86 It is expressed in immune privileged sites and is implicated in establishin

87 ter the hypothesis that B cell follicles are immune privileged sites and suggest that strategies to a

88 rticipation in inflammatory responses within immune privileged sites such as the brain and eye is les

89 The induction of peripheral tolerance via immune privileged sites such as the eye requires splenic

90 In immune privileged sites such as the eye, CD95 ligand (Fa

91 sion helps control inflammatory reactions in immune privileged sites such as the eye.

92 ic infections in humans, mainly localized in immune privileged sites, such as the brain and the eye.

93 IFN-dependent MHC regulation, as evident in immune privileged sites.

94 sponse in controlling lymphocyte function in immune privileged sites.

95 Diffuse large B-cell lymphoma arising in immune-privileged sites (eg, the central nervous system)

96 nance of tolerance, as Fas ligand can create immune-privileged sites and prevent graft rejection by i

97 if somatic stem-cell niches more broadly are immune-privileged sites by examining the haematopoietic

98 Thus, dysregulated innate immunity at immune-privileged sites may be an essential mechanism tr

99 , suggesting that tumor cells originating in immune-privileged sites may have enhanced capacity for i

100 Implantation of RPE cells in immune-privileged sites of the eye induces a deviant imm

101 Tissues derived from immune-privileged sites sometimes possess special charac

102 in view of the immune deviation existing in immune-privileged sites such as the brain and eye, where

103 g how EBOV disseminates into and persists in immune-privileged sites was impossible due to the absenc

104 nous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and muri

105 se the brain and testis are considered to be immune-privileged sites, the expression pattern of cdr2

106 are immune-suppressive environments, called immune-privileged sites, where multiple mechanisms coope

107 ion and promoted the establishment of cancer immune-privileged sites.

108 e highlight a dilemma that is central to all immune-privileged sites.

109 d, suggesting that lymphoid follicles may be immune-privileged sites.

110 n the development of peripheral tolerance in immune-privileged sites.

111 virus can persist in survivors for months in immune-privileged sites; however, viral relapse causing

112 ccommodate and even differentiate in the non-immune-privileged space beneath the kidney capsule.

113 he accessibility for routine surgery and its immune privileged state make the eye an ideal target for

114 l inflammation that subvert the normal eye's immune privileged state.

115 especially TGF-beta2, that contribute to the immune privileged status of the anterior chamber.

116 tures of the corneal graft contribute to its immune privileged status: (a) absence of donor-derived,

117 this class Ib protein may contribute to the immune-privileged status of the anterior chamber.

118 ged self during healing and suggest that the immune-privileged status of the CNS may contribute to fa

119 n (IRBP) in the periphery, thus revoking its immune-privileged status.

120 t even though the retina is often considered immune-privileged, suppression of host immune-mediated c

121 long been reported to be hypoimmunogenic or 'immune privileged'; this property is thought to enable M

122 The cornea is an immune privileged tissue that, when grafted orthotopical

123 as much to the qualities of the graft as an immune-privileged tissue as to the qualities of the eye

124 tinal pigment epithelium (RPE) behaves as an immune-privileged tissue when transplanted extraocularly

125 endritic cells (DC) reside in the cornea, an immune-privileged tissue, is unknown.

126 sed on the cell surface of many tumor cells, immune-privileged tissues and activated lymphocytes.

127 er, CX3CR1(hi) patrolling monocytes serve as immune-privileged vehicles to transport MCMV via the blo

128 rast to the notion that ES-derived cells are immune-privileged, we show in this study that NK cells f