ライフサイエンスコーパス: immune-related

1 ight index components of asthma that are not immune-related.

2 Immune-related abnormalities are commonly reported in sc

3 The immune-related activity of AQP was confirmed in vivo in

4 Given the frequency of immune related adverse events and increasing use of ICB,

5 their use can also be associated with unique immune-related adverse effects (irAEs).

6 However, given its mechanism of action, immune-related adverse effects have been reported with t

7 Despite increasing reports of immune-related adverse effects related to ipilimumab the

8 er, these new treatments are associated with immune-related adverse effects that can involve differen

9 tentially providing key information to limit immune-related adverse effects.

10 safety defined as any grade 3 or greater or immune-related adverse event (AE) and the change in HIV-

11 Vitiligo, a clinically visible immune-related adverse event could be associated with cl

12 oduces a diverse and unpredictable number of immune-related adverse events (IRAE).

13 ndard treatment for metastatic melanoma, but immune-related adverse events (irAEs) are common and can

14 Grade 3 or 4 immune-related adverse events (irAEs) were observed in 1

15 quency of autoimmune flares and conventional immune-related adverse events (irAEs), and efficacy, in

16 ssociated with unique side effects, known as immune-related adverse events (irAEs), which need to be

17 que set of adverse effects may occur, called immune-related adverse events (irAEs).

18 inflammatory responses and toxicities termed immune-related adverse events (irAEs).

19 ansferases (two patients), grade 3 endocrine immune-related adverse events (two patients), and grade

20 hysicians should be aware of these potential immune-related adverse events and consider drug-associat

21 To explore this, we analyzed immune-related adverse events and immune responses in me

22 erapy: we have characterized the spectrum of immune-related adverse events and learned how to mitigat

23 ration for evaluation of efficacy as well as immune-related adverse events associated with anti-CTLA-

24 e adds to the expanding literature regarding immune-related adverse events associated with ipilimumab

25 immune system did not seem to exacerbate the immune-related adverse events associated with ipilimumab

26 iated with numerous cancers, but high-grade, immune-related adverse events can occur, particularly wi

27 Serious immune-related adverse events did not differ between gro

28 The most common grade 3-4 immune-related adverse events in the ipilimumab group we

29 Grade 3 or 4 immune-related adverse events included diarrhoea or coli

30 A variety of dermatologic immune-related adverse events including maculopapular er

31 ts are typically well tolerated, the risk of immune-related adverse events increases with combination

32 Grade 3 or 4 immune-related adverse events occurred in 10 to 15% of p

33 Grade 3 or 4 immune-related adverse events occurred in 36% of patient

34 Immune-related adverse events of any grade arose in 50 o

35 Immune-related adverse events of grade 3 or 4 occurred i

36 Six patients exhibited immune-related adverse events of mild-to-moderate intens

37 to checkpoint protein inhibitors that induce immune-related adverse events that are autoinflammatory

38 The most common grade 3 immune-related adverse events were diarrhoea (six patien

39 ontinued to receive ipilimumab, grade 3 or 4 immune-related adverse events were observed exclusively

40 There were more immune-related adverse events with ipilimumab than with

41 th a unique pattern of adverse events called immune-related adverse events, and occasionally, unusual

42 Immune-related adverse events, including one death, were

43 nt immune activation while avoiding limiting immune-related adverse events.

44 21 patients had grade 2 or greater immune-related adverse events.

45 udy drugs (2.1%), and 7 were associated with immune-related adverse events.

46 in, gastrointestinal, endocrine, and hepatic immune-related adverse events.

47 3 patients with new lesions associated with immune-related adverse events.

48 Usually, side effects are immune-related adverse events.

49 mumab group, 5 patients (1.1%) died owing to immune-related adverse events.

50 tients required dose interruption because of immune-related adverse events: one (4%) of 25 each had g

51 symptomatic hypophysitis (a protocol-defined immune-related AE) was identified 266 days after BMS-936

52 Overall rates of grade 3 and 4 immune-related AEs were 15%, 20%, and 6% for phased ipil

53 (8%) were treated with systemic steroids for immune-related AEs.

54 s were of all treatment-related AEs, select (immune-related) AEs, time to onset and resolution, and u

55 ny of the commonly regulated transcripts are immune related and include the complement components C1q

56 okine signaling and upstream inflammation in immune-related and other chronic diseases.

57 nctional analysis of these miRNA targets, 12 immune-related biological processes were found to be sig

58 l mucosa, and transcriptional differences in immune-related biological processes.

59 al (PFS), best overall response rate (BORR), immune-related BORR (irBORR), overall survival (OS), and

60 rview of the current therapeutic success and immune-related burden of secondary effects of checkpoint

61 Incidence of infection-related and immune-related cancer was higher during kidney function

62 Prominent immune-related cargos of plant trafficking pathways are

63 As expected, immune-related categories show the largest enrichment si

64 d association signal is not only produced by immune-related categories, but also by most other catego

65 Adverse events consistent with immune-related causes were observed.

66 own to play an immunoregulatory role in many immune-related cell types, and activation of PPARgamma w

67 nstrate a novel enrichment method to capture immune-related cells from clinical airway secretions usi

68 nding of their biology and interactions with immune-related cells.

69 ceptors, which are expressed on NK and other immune-related cells.

70 We further investigated immune-related changes in the aged liver and found that

71 , our results establish the critical role of immune-related changes, with key contributions for CD40L

72 ent with baseline psoriasis died of presumed immune-related colitis after a 1-week delay prior to rep

73 hort A died of drug-related complications of immune-related colitis.

74 e crucial given the risk of life-threatening immune-related complications associated with these thera

75 FA patients have high susceptibility to immune-related complications such as infection and postt

76 the authors collected personal histories of immune-related conditions and use of immune-modulating t

77 lts suggest that disordered immunity in some immune-related conditions can lead to NHL.

78 ted diseases were more likely and those with immune-related conditions were not less likely to initia

79 tic strategy for many mucosal and nonmucosal immune-related conditions, such as inflammatory bowel di

80 ety of human diseases, especially cancer and immune-related conditions.

81 s health-related conditions, and 5) selected immune-related conditions.

82 CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer ther

83 y have therapeutic potential in a variety of immune-related cutaneous diseases.

84 m, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pa

85 tion was employed to measure mRNA levels for immune-related cytokines and transcriptional regulators,

86 Immune-related deficiencies are well-known complications

87 In addition, a significant number of immune related DEGs were identified.

88 s in survival between these two tumor types, immune-related differences in cell content are potential

89 on signatures predicted clinical outcome and immune-related differences in the microenvironment.

90 sponse mechanisms that are shared with other immune-related disease modules.

91 gest that TLR1 polymorphisms could influence immune-related disease through Teff resistance to Treg s

92 tified in genome-wide association studies of immune-related disease, suggesting that both alleles are

93 of circadian homeostasis is associated with immune-related disease.

94 roxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA

95 of the implicated loci were associated with immune-related diseases (including asthma, connective ti

96 nding and management of other lymphatic- and immune-related diseases in general.

97 ), associations with genes implicated in non-immune-related diseases including lipid profiles, anthro

98 ribution of allelic variants to the onset of immune-related diseases remain mostly unknown.

99 als receiving immunomodulatory therapies for immune-related diseases such as multiple sclerosis.

100 ymorphisms have been associated with several immune-related diseases, and VDR and vitamin D itself mo

101 tment revises downward the h(2) estimate for immune-related diseases, as expected because of high LD

102 Hormonal imbalances are documented in immune-related diseases, but it is unclear whether this

103 has been used as treatment for a variety of immune-related diseases, including immune thrombocytopen

104 ers, is associated with an increased risk of immune-related diseases, including several cancers.

105 us on the role of osteopontin in a series of immune-related diseases, particularly those where signif

106 ctivation of immune cells and their roles in immune-related diseases.

107 is important for understanding and treating immune-related diseases.

108 new immunomodulatory drugs in the therapy of immune-related diseases.

109 rtcut to identifying potential mechanisms of immune-related diseases.

110 hought to be associated with a wide range of immune-related diseases.

111 s of gene expression, neutrophil biology and immune-related diseases.

112 aking them attractive targets for modulating immune-related diseases.

113 n/AR may help in treatment and management of immune-related diseases.

114 effects of SCIT on the risk of other chronic immune-related diseases.

115 could be a potential therapeutic target for immune-related diseases.

116 vary considerably in their susceptibility to immune-related diseases.

117 n the initiation and development of adaptive immune related disorders.

118 ing via C-type lectin receptors, and several immune-related disorders are associated with CARD9 alter

119 g of Fbxo3 might be a promising strategy for immune-related disorders characterized by a heightened h

120 on and pleiotropy with other psychiatric and immune-related disorders were estimated.

121 Chronic pain may accompany immune-related disorders with an elevated level of serum

122 linked polyubiquitin have been implicated in immune-related disorders.

123 thobiology of a wide array of infectious and immune-related disorders.

124 reatment of multiple sclerosis (MS) or other immune-related disorders.

125 ved between PTSD and 6 mental disorders or 9 immune-related disorders.

126 y whether higher IFITM mRNA levels and other immune-related disturbances in the prefrontal cortex are

127 In contrast, immune-related effector gene promoters within naive T ce

128 ade 3-4 adverse events were gastrointestinal immune-related events (11 in the 10 mg/kg group, two in

129 Understanding the mechanisms by which immune-related events in the periphery can influence bra

130 Immune-related events in the periphery can remotely affe

131 ese observations support the hypothesis that immune-related exposures, especially atopy, are associat

132 creased expression and lack of activation of immune-related factor NF-kappaB.

133 us-specific, host genetic, environmental and immune-related factors are likely to determine the progr

134 d regulatory factors, secreted proteins, and immune-related factors, and represent powerful tools for

135 eukaryotic life and play a broader, possibly immune-related function outside venom.

136 sociated genes are significantly enriched in immune-related functions and closer with each other in t

137 eled top-to-bottom approach and demonstrated immune-related functions for them, further validating th

138 Many of these genes have immune-related functions involved in signaling pathways,

139 e reconnoitering, as well as a number of non-immune-related functions necessary for proper embryogene

140 nities to mannose-binding lectin, suggesting immune-related functions of paucimannosylation in activa

141 , and describe how novel gene regulatory and immune-related functions of these ncRNAs may impact the

142 ts show that numerous genes, some with known immune-related functions, predispose to SLE.

143 od cells is necessary to maintain the cells' immune-related functions.

144 determine if differences in early postinjury immune-related gene expression are associated with subse

145 formation has been associated with a unique immune-related gene expression signature composed of dis

146 factor that mediates cytokine regulation of immune-related gene expression.

147 s for variants in the functionally important immune-related gene MBL2.

148 However, a robust map of immune-related gene networks in circulating human cells,

149 greatly affected expression of inflammation/immune related genes over the course of the ASRV infecti

150 ser captured portal tracts were enriched for immune related genes when compared with hepatocytes but

151 These loci are enriched for immune-related genes (such as OAS1/2/3, TLR1/6/10, and T

152 infection, we examined common variants in 11 immune-related genes among Jamaican children born to HTL

153 The overall enrichment of immune-related genes among those differentially expresse

154 eads to a significant upregulation of innate immune-related genes and an increase in the number of ce

155 origination of several evolutionarily novel immune-related genes and gene families.

156 ate interrelationships between expression of immune-related genes and immunity pathways in the host w

157 s infection resulted in the up-regulation of immune-related genes and the down-regulation of many coa

158 are integrated with the regulation of other immune-related genes are not known.

159 conditional deletion of Tet1 and found that immune-related genes are the most highly dysregulated.

160 al transcripts and expression levels of host immune-related genes at 1 day post infection (dpi) were

161 found: (1) A divergent expression pattern of immune-related genes between lines of different genetic

162 However, the numbers of expressed immune-related genes between these two comparisons were

163 ccurrence of inherited damaging mutations in immune-related genes compared to patients with solitary

164 with an almost complete lack of induction of immune-related genes during the initial 24 hrs post-expo

165 We discovered AS events for >100 immune-related genes encoding receptor-like kinases, NB-

166 A total of 149 immune-related genes in 20 gene families were identified

167 The expression of immune-related genes in mammary epithelial cells indicat

168 identify signatures of positive selection on immune-related genes in the ancient but not the modern g

169 er, these findings demonstrate activation of immune-related genes in the PFCTX during inflammatory pa

170 and paralogs of 245 Drosophila melanogaster immune-related genes in these recently sequenced genomes

171 that these miRNAs regulate several critical immune-related genes including SLC11A1, PIGE-108A11.3 an

172 The analysis of the immune-related genes indicated that SE infection induced

173 e studies suggesting that high expression of immune-related genes indicates active and targetable dis

174 ted the hypothesis that genetic variation in immune-related genes is a determinant of susceptibility

175 study demonstrates that genetic variation in immune-related genes is associated with susceptibility t

176 The higher expression of immune-related genes might be more beneficial to enhance

177 ancer 730-Immune Panel, and we identified 23 immune-related genes or signatures linked to response an

178 Several immune-related genes possess this cAMP-responsive elemen

179 age, detoxification, nutrient recycling, and immune-related genes relevant for facilitating interacti

180 Recent studies found an enrichment of immune-related genes subjected to natural selection, sug

181 FBR1, the proto-oncogene MYB as well as many immune-related genes such as CCR7 and FCRL3, reinforcing

182 early somatic mutations in oncogenesis- and immune-related genes that may represent key initiators o

183 characterization of several inborn errors of immune-related genes that underlie inherited human susce

184 Additionally, increased expression of immune-related genes was correlated with longer time to

185 An unexpectedly large set of immune-related genes was induced by afferent deprivation

186 ecretory antigenic target 6, and mRNA for 45 immune-related genes was measured by quantitative real-t

187 Expression profiling for immune-related genes was performed on select HIV-positiv

188 ting and activated T cells, identifying many immune-related genes with differential expression.

189 is of the DR revealed a dramatic increase in immune-related genes, and dysregulation of genes importa

190 creased levels of proinflammatory cytokines, immune-related genes, and schizophrenia as well as brain

191 e common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic au

192 Among the differentially expressed immune-related genes, B3GNT2 is implicated in autoimmune

193 p-scoring upregulated module was enriched in immune-related genes, consistent with activation of micr

194 Other immune-related genes, Il2rg, Fcgr2b, C1qb, Ptprc, and Cc

195 We also identified 466 immune-related genes, which may be useful for studying T

196 ffected the transcriptional response of most immune-related genes, with age effects being more stimul

197 o synonymous mutation rate even greater than immune-related genes.

198 m deep transcriptome analyses to investigate immune-related genes.

199 ibility complex, a region that contains many immune-related genes.

200 e function by reducing methylation levels of immune-related genes.

201 or Notch pathway components and inflammation/immune-related genes.

202 variants that dysregulate the expression of immune-related genes.

203 endothelial mRNA expression of a variety of immune-related genes.

204 hips containing more than 700 neuroendocrine-immune-related genes.

205 A expression of a subset of inflammatory and immune-related genes.

206 ader role for CIITA beyond the MHC involving immune-related genes.We provide new insights into allele

207 underscored by the recent identification of immune-related genetic risk factors for AD, including co

208 n signal at the HLA locus and imply that the immune-related genetic susceptibility to PD is likely to

209 genes in human are predominantly enriched in immune related GO terms while viral HGT genes are tend t

210 Immune-related grade 3 to 4 AEs occurred in 31% and 2% o

211 novel virulence-related microbial genes and immune-related host genes, many of which have been valid

212 Our results raise the possibility that an immune-related imbalance in the relative metabolism of K

213 inate in the caudal brainstem that propagate immune-related information from the periphery with multi

214 -lasting maladaptive response to an in utero immune-related insult.

215 The genes identified were mainly immune related, involving interferon gamma pathways and

216 standing of the mechanism of action of these immune-related lncRNAs, discuss their impact on physiolo

217 D may be the result of positive selection on immune related loci in the genome to fight infection.

218 recent study with high-density genotyping of immune-related loci in individuals with Asian ancestry i

219 d evidence for association at six additional immune-related loci not previously implicated in PBC and

220 eralized vitiligo and SNPs in two additional immune-related loci, RERE (P=7.07x10(-15)) and GZMB (P=3

221 d its dysregulation has been associated with immune-related malignancies.

222 Subtype associations for several immune-related markers-including PD1, PDL1, CD3 and CD8-

223 Higher tissue transcript levels of immune-related markers-including the recently discovered

224 nervous system (CNS) is endowed with several immune-related mechanisms that contribute to its protect

225 The correlation between immune-related modules and schizophrenia was replicated

226 Here, we show that the immune-related molecule B7-1/CD80 is a critical mediator

227 udies demonstrated surprising dual roles for immune-related molecules and their effector mechanisms d

228 llus fumigatus induces the release of innate immune-related molecules from phagocytic cells early in

229 ls and a significant upregulation of several immune-related monocyte genes compared with control subj

230 e BSC group (P = .43), the most common being immune related, nonfebrile neutropenia, gastrointestinal

231 The immune-related objective response rate and immune-relate

232 The coprimary end points were the immune-related objective response rate and the 20-week i

233 mismatch repair-deficient colorectal cancer (immune-related objective response rate, 71% [5 of 7 pati

234 he most common grade 3-4 adverse events were immune-related, occurring in 101 (26%) patients in the i

235 imilar levels as full-length Md1 in the main immune-related organs of zebrafish and are highly induce

236 vations together with the discovery of other immune-related p53 target genes provide new insights int

237 h immune protection, without the significant immune-related pathogenic risk associated with type I IF

238 Krabbe disease, placing patients at risk of immune-related pathologies, and identifies a novel targe

239 f immune homeostasis comes from a variety of immune-related pathologies, such as autoimmune diseases,

240 ce infected with the acr2 mutant and reduced immune-related pathology.

241 .6x10(-5)), and trans-regulation of genes in immune-related pathways (P=1.6x10(-32)).

242 LA) and non-HLA genes, most of which involve immune-related pathways and modifiers of immune function

243 is revealed enrichment of cell migration and immune-related pathways in CTC clusters, suggesting surv

244 Immune-related pathways included leukocyte trafficking a

245 y (GO) analyses revealed lower expression of immune-related pathways such as chemokine receptor activ

246 trix and transport, as well as oncogenic and immune-related pathways transduced by plasma membrane re

247 ene signature reflecting bone remodeling and immune-related pathways was upregulated in high compared

248 d, blood, and brain tissues are enriched for immune-related pathways, consistent with other expressio

249 dramatic decreases in expression of numerous immune-related pathways, including Ag presentation and T

250 markers (e.g. IL10), and modulated multiple immune-related pathways.

251 of cigarette smoking revealed enrichment for immune-related pathways.

252 nches of medicine, the marked variability in immune-related phenotypes and the highly complex network

253 y be successfully used for ASD patients with immune-related phenotypes.

254 types declined with time, which could be an immune-related problem and/or due to other factors intri

255 In the spleen, immune-related processes including NK cell cytotoxicity

256 The primary end point was immune-related progression-free survival (irPFS).

257 e immune-related objective response rate and immune-related progression-free survival rate were 40% (

258 ective response rate, 71% [5 of 7 patients]; immune-related progression-free survival rate, 67% [4 of

259 ated objective response rate and the 20-week immune-related progression-free survival rate.

260 shown to exert metabolic, inflammatory, and immune-related properties and thereby could be implicate

261 ghly expressed in microglia and highlight an immune-related protein-protein interaction network enric

262 nflammatory cytokines, chemokines, and other immune-related proteins.

263 asize that altering the function of a single immune-related receptor can dramatically change the repa

264 na shows evidence of glial activation and an immune-related response after IOP elevation, similar to

265 vival and best overall response measured per immune-related response criteria (irRC) and Response Eva

266 nary toxicity were prospectively assessed by Immune-related Response Criteria and Common Terminology

267 Response was assessed by using immune-related response criteria and modified WHO criter

268 y end points were objective response rate by immune-related response criteria and safety.

269 nation of tumour progression outlined by the immune-related response criteria and the RANO working gr

270 -month disease control rate according to the immune-related response criteria served as the primary e

271 se (PR) using RECIST criteria (two PRs using immune-related response criteria), and three instances o

272 CR was defined per investigator assessment, immune-related response criteria, and potential predicto

273 response rate evaluated by investigators per immune-related response criteria.

274 2%, with a complete response rate of 33% per immune-related response criteria.

275 ion Criteria in Solid Tumors version 1.1 and immune-related response criteria.

276 An immune-related response occurs with activation of cytoki

277 ical activity (conventional, unconfirmed, or immune-related response or stable disease for >/=24 week

278 Proof-of-concept is established for immune-related rheumatoid arthritis and inflammatory bow

279 isks associated with specific treatments and immune-related risk factors have not been quantified.

280 ious adverse events (SAEs), five of whom had immune-related SAEs, including two with adrenal insuffic

281 Although the number of available immune-related scRNA-seq datasets increases rapidly, the

282 e, we created the JingleBells repository for immune-related scRNA-seq datasets ready for analysis and

283 collected the raw data of publicly available immune-related scRNA-seq datasets, aligned the reads to

284 and treatment is often accompanied by severe immune-related side effects, suggesting the importance o

285 mune cells of the brain, express and secrete immune-related signaling molecules that alter synaptic t

286 sceptible patients show early alterations in immune-related signaling pathways, epigenetic modulation

287 erferon-gamma, T-cell receptor, and expanded immune-related signaling pathways.

288 NF-kappaB signaling and the emergence of an immune-related signature in OA cartilage over time.

289 We identified immune-related signatures correlating with clinical bene

290 Proliferation and immune-related signatures determined three ILC transcrip

291 e association studies (GWAS) have identified immune-related single-nucleotide polymorphisms (SNPs) as

292 identified two main subtypes of ILCs: (i) an immune related subtype with mRNA up-regulation of PD-L1,

293 Patients with HIV-1 immune-related thrombocytopenia (HIV-1-ITP) have a uniqu

294 Patients with HIV-1 immune-related thrombocytopenia have a unique antibody (

295 ts with advanced melanoma but cause frequent immune-related toxic effects.

296 ers, suggesting that markers associated with immune-related traits might also play a role in AD.

297 These alternations in many immune-related transcripts and biological processes resu

298 ight be associated with nutrient uptake, and immune-related transcripts including antimicrobial pepti

299 Recent breakthroughs in novel immune-related treatment strategies for cancer have spur

300 Immune-related treatment-related events occurred in 22 p