ライフサイエンスコーパス: immunity

1 particular iron, which leads to "nutritional immunity".

2 uired for participation of Tregs in anti-WNV immunity.

3 eby enhancing suppression of Th1 anti-tumour immunity.

4 implications for blood disorders, aging, and immunity.

5 system, and how this may influence adaptive immunity.

6 ture RRCs express genes implicated in innate immunity.

7 ther it was evaluated by humoral or cellular immunity.

8 pamycin is used to stimulate vaccine-induced immunity.

9 dering the metastases susceptible to mucosal immunity.

10 thway of autophagy has a fundamental role in immunity.

11 duces memory potential and impairs antitumor immunity.

12 s essential for T cell function and adaptive immunity.

13 nt and a significant role in regulating oral immunity.

14 es new insights into human anti-tuberculosis immunity.

15 e transcriptional regulation of plant innate immunity.

16 fector cell interaction in mediating humoral immunity.

17 n were produced through maternal educational immunity.

18 and may contribute to protective anticancer immunity.

19 cyte respiratory burst is crucial for innate immunity.

20 les disease to progress unabated by adaptive immunity.

21 e cell subsets involved in antiviral humoral immunity.

22 an essential component of long-lived T cell immunity.

23 is not required for generation of effective immunity.

24 supramolecular organization are critical for immunity.

25 central regulator in energy homeostasis and immunity.

26 syndrome, suggesting abnormality of adaptive immunity.

27 rtly on induction of sustainable host T-cell immunity.

28 g the generation of CT26-specific protective immunity.

29 l circuits that regulate innate and adaptive immunity.

30 tumour microenvironment restricts antitumour immunity.

31 and an antigenically variable target of host immunity.

32 ls initiate and maintain innate and adaptive immunity.

33 on while preserving and enhancing protective immunity.

34 ets that likely compromise anti-tumor T cell immunity.

35 ence of spontaneous or therapeutic antitumor immunity.

36 TLR4 agonist capable of inducing anti-tumor immunity.

37 r of defense-induced lignification and basal immunity.

38 early modulation of the host microbiota and immunity.

39 is (ADCP) activity, implicated in protective immunity.

40 roduction source of ET-1 in inflammation and immunity.

41 e responses that are required for anti-tumor immunity.

42 pand upon demand, thereby providing lifelong immunity.

43 ng antibodies, as well as weak cell-mediated immunity.

44 cytokines are central mediators of mammalian immunity.

45 s transgenerational inheritance of antiviral immunity.

46 ssions might reduce its impact on population immunity.

47 for complete and long-lasting anti-influenza immunity.

48 ons between DNA replication, DNA repair, and immunity.

49 instability locally and restores anti-tumor immunity.

50 nate link between viral infection and B cell immunity.

51 ent vaccine adjuvant of humoral and cellular immunity.

52 t not reflect alterations in tissue-specific immunity.

53 DB1 as a novel, negative regulator of innate immunity.

54 mpromise both leukemia and pathogen-specific immunity.

55 f STKR1 function, SnRK1 signaling, and plant immunity.

56 iological context: suppression of anti-tumor immunity.

57 ing reflexively regulate innate and adaptive immunity.

58 ic clearance of parasites, and regulation of immunity.

59 ological processes, including hemostasis and immunity.

60 s immune and metabolic correlates of vaccine immunity.

61 te overlapping pathways to promote antitumor immunity.

62 B7-1 interactions, reinvigorating anticancer immunity.

63 al toll-like receptors and antiviral humoral immunity.

64 harnessing these receptors to augment tumor immunity.

65 withstand numerous stresses imposed by host immunity.

66 e that GAS employs to circumvent host innate immunity.

67 MC38 tumor cells allows effective antitumor immunity.

68 out the molecular mechanisms driving vaccine immunity.

69 e new insight into the regulation of humoral immunity.

70 ue and aim to elicit protective CTL-mediated immunity.

71 es in cancer cells while inducing anti-tumor immunity.

72 nd an important regulator of pain and innate immunity.

73 iagnose and identify correlates of long-term immunity.

74 r an essential role of a DNA sensor in human immunity.

75 also the first record of phages evading that immunity (1) .

76 itates the emergence of potent CD8(+) T-cell immunity able to durably suppress virus replication.

77 nsmission has the benefit of increasing herd immunity above that achieved by direct vaccination alone

78 thogen-specific SIgA in addition to systemic immunity achieved by injected vaccines.

79 Adaptive immunity, addressed here, integrates the activities of d

80 t CD8(+) T cells are required for protective immunity against a naturally occurring murine pathogen t

81 In the wake of an epidemic, established immunity against a particular disease can limit spread a

82 consensus vaccines induce superior levels of immunity against a wide divergence of influenza subtypes

83 hetic enzymes as a means to strengthen plant immunity against biotrophic pathogens.

84 eading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD)

85 Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin

86 l motility are essential for adaptive T-cell immunity against infectious pathogens and cancers.

87 Taken together, PRELP enhances host innate immunity against M. catarrhalis through increasing compl

88 Moreover, IFN-lambda-mediated sterilizing immunity against murine norovirus requires the capacity

89 I proteins initiates CD8(+) T cell-mediated immunity against pathogens and cancers.

90 MRA cells have been implicated in protective immunity against pathogens such as dengue virus (DENV).

91 4 TRM cells play a critical role in adaptive immunity against reinfection and memory induced by natur

92 ons about the strength of naturally acquired immunity against rotavirus gastroenteritis (RVGE), mirro

93 th the batA mutant strain elicits protective immunity against subsequent infection with wild-type bac

94 -directed therapy aimed at manipulating host immunity against TB.

95 e to look for variants that provide enhanced immunity against viral infection.

96 as likely evolved to both sustain protective immunity and avoid autoantibody production.

97 tablish a link between Type III-A CRISPR-Cas immunity and central nucleic acid metabolism.

98 y in metazoans predates interferon-inducible immunity and comprises primordial innate defense.

99 SOCS2 limits adaptive anti-tumoral immunity and DC-based priming of T cells in vivo, indica

100 eostasis to key determinants of anti-tumoral immunity and escape, revealing co-opting of tissue-speci

101 issue-specific regulation of CD1d-restricted immunity and further suggest that alterations in lipid m

102 H3N8 IIV but provided limited cross-reactive immunity and heterologous protection against H3N2 CIV.

103 efit from learning about the vaccine-induced immunity and identifying correlates of malaria protectio

104 e one strategy to boost vaccination-promoted immunity and improve outcomes associated with highly pat

105 itic cells (pDCs) are important in antiviral immunity and in maintaining tolerance to inert antigens.

106 munodeficiency virus type 1 (HIV-1)-specific immunity and increase clearance of HIV-1-expressing cell

107 Moreover, hyperactive immunity and increased enterocyte death resulted in the

108 ression, pathogen elimination, regulation of immunity and inflammation, maternal DNA inheritance, met

109 ibe how macrophages change during protective immunity and inflammation.

110 ore unrecognized regulatory event underlying immunity and inflammatory disease, and a novel target fo

111 ests the commensal microbiome regulates host immunity and influences brain function; findings that ha

112 ay reflect impaired maturation of intestinal immunity and integrity in boys with a risk of JIA.

113 Given this role in adaptive immunity and its highly monomorphic nature in the human

114 ay be targeted to promote long-lived humoral immunity and resistance to malaria.

115 ctivated vaccines by eliciting local mucosal immunity and systemic B cell- and T cell-mediated memory

116 nique interaction patterns regulating innate immunity and viral infection.

117 kshop 'Complex Systems Science, Modeling and Immunity' and subsequent discussions regarding the poten

118 This effect has been termed 'trained innate immunity', and is underwritten by stable epigenetic chan

119 ne microenvironment to promote innate type 2 immunity, and also to integrate systemic metabolic and t

120 sues play important roles in homeostasis and immunity, and CRS significantly impairs these normal fun

121 ria within the microbiota that regulate lung immunity, and delineate the host signaling axis they act

122 ctious agents boost humoral but not cellular immunity, and have poorly-understood mechanisms.

123 roinvasiveness, induction of strong adaptive immunity, and protection of mice from wild-type (WT) WNV

124 in tumor-associated blood vessels and tumor immunity, and provide an update on mTOR inhibitors.

125 light on the interaction between metabolism, immunity, and tissue communication.

126 t interactions relevant to drug response and immunity, and we highlight how such improvements enable

127 Both innate and adaptive immunities are involved.

128 alidate that the prime targets of protective immunity are conformational epitopes at the dimer interf

129 sceptibility to infection or graft-vs.-tumor immunity are hampered by the lack of a physiologically r

130 tal principles of innate control of adaptive immunity are well established, it is not fully understoo

131 igate the prognostic role of host antitumour immunity as represented by baseline quantities of TILs i

132 This response is selective for TH 2 immunity as TH 1 and TH 17 immunity is largely unaffecte

133 s.IgE is an important mediator of protective immunity as well as allergic reaction, but how high affi

134 potential for this process to influence lung immunity as well.

135 ma cells is sufficient to suppress antitumor immunity, as deletion of PD-L1 on highly immunogenic MC3

136 suggested a role for PLC2 in MAMP-triggered immunity, as it is rapidly phosphorylated in vivo upon t

137 ecular understanding of type-2-cell-mediated immunity, as well as new areas such as the microbiome.

138 el inborn error of IL-12-dependent IFN-gamma immunity associated with susceptibility to paracoccidioi

139 We assessed cutaneous immunity based on the extent of erythema and induration

140 cer Atlas (PCA), integrating multi-omics and immunity - basic tenets of the neoplastic process.

141 pidemiological modelling suggests that cross-immunity between RSV, HMPV and human parainfluenzaviruse

142 PPD/polyIC invokes antitumor immunity, but unlike many immunotherapies does not need

143 n avirulent pathogen that elicits protective immunity, but we discovered that it can nonetheless disr

144 o opposing mechanisms: protection from fatal immunity by amphiregulin expression and augmentation of

145 e kinase Akt in the generation of protective immunity by CD8(+) T cells.

146 y spots (MSs), that contribute to peritoneal immunity by collecting antigens, particulates, and patho

147 HIV-associated dysregulation of adaptive immunity by depletion of CD4 Th cells most likely contri

148 R-Cas systems provide microbes with adaptive immunity by employing short DNA sequences, termed spacer

149 (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J recombination in developing

150 l enteric fungi safeguard local and systemic immunity by providing tonic microbial stimulation that c

151 e HLA-E plays an important role in antiviral immunity by regulating natural killer and CD8(+) T cells

152 servations of species-specific regulation of immunity by vitamin D, the VDREs are present in primate

153 can cross MHC class I barriers and that Th1 immunity can be imparted to Th2-biased offspring; in som

154 ersistent infection demonstrates that innate immunity can control both early and persistent viral rep

155 We conclude that lactational transfer of immunity can cross MHC class I barriers and that Th1 imm

156 nated activation of both innate and adaptive immunity can effectively reduce the risk of tumor recurr

157 Suppression of TH2 immunity can occur as a consequence of either deletion o

158 y and genes related to extracellular matrix, immunity, cell adhesion, epigenetic regulation, and airf

159 rt of melanoma patients reveal how tumor and immunity co-evolve during anti-PD-1 therapy.

160 ffecting the expression of genes involved in immunity, defense, and development.

161 the microbiota where flies with constitutive immunity defined the gut microbiota of their cohabitants

162 ration of TTP expression enhances anti-tumor immunity dependent on degradation of PD-L1 mRNA.

163 re neutralized by adjacently encoded cognate immunity determinants.

164 portant new strategy for understanding human immunity directly, taking advantage of the many ways the

165 or all vaccine type-related cancers and herd immunity effects from vaccinating girls and boys.

166 udies will be needed to assess possible herd immunity effects with meningococcal serogroup B vaccines

167 about the establishment of effective B cell immunity elicited by vaccination, not just against HIV-1

168 In this review, we address how social immunity emerges from its mechanistic components to prod

169 approach to initiate local antigen-specific immunity, enhance previously existing systemic immunity

170 ver, T cells are also critical in protective immunity, especially in immune-compromised patients.

171 at the interface between innate and acquired immunities following their recruitment to inflamed tissu

172 rent efforts focus on understanding cellular immunity for targeted vaccine development.

173 ned by a combination of a lack of homologous immunity, frequent reinfections, weak competition betwee

174 ible for the high diversity of T6SS effector-immunity gene profiles observed for V. cholerae and clos

175 Each sitA is associated with a cognate sitI immunity gene, and in some cases a sitB accessory gene.

176 clusters each encode a pair of effector and immunity genes downstream of those encoding the T6SS str

177 merous strains possess long arrays of orphan immunity genes encoded in the 3' region of their T6SS cl

178 we found one that evaded the CRISPR-encoded immunity >40,000x more often than the others.

179 ination, the hallmark of vertebrate adaptive immunity, has the potential to generate a vast diversity

180 the principal antigens that invoke effective immunity have remained unchanged, distinct A:cc5 epidemi

181 ically examined the biomarkers of protective immunity however the biomarkers of attenuation in the pa

182 cyclic dinucleotide (CDN)-driven anti-viral immunity; however, a major hindrance is STING's cytosoli

183 rimary function of most T3SEs is to suppress immunity; however, the plant can evolve nucleotide-bindi

184 helminth infection potently inhibits T cell immunity; however, whether helminthes prevent T cell pri

185 as been associated with avoidance of humoral immunity, i.e., B cell activation and antibody neutraliz

186 l of infection yet still elicited protective immunity.IMPORTANCE The vaccinia virus (VACV) K1 protein

187 hanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism.

188 e associated with vaccine-induced protective immunity in challenge studies involving nonhuman primate

189 eed-Sternberg (HRS) cells to evade antitumor immunity in classical Hodgkin lymphoma (cHL).

190 The role of adaptive immunity in early cancer development is controversial.

191 Effective anti-tumour immunity in humans has been associated with the presence

192 s, suggesting that there may be minimal herd immunity in humans.

193 efore a novel functional component of T-cell immunity in latent TB and potential correlate of protect

194 Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immu

195 has emerged as a key mechanism of antiviral immunity in metazoans, including the selective eliminati

196 may provide a link between mucosal and joint immunity in patients with RA.

197 icrobial peptides contributing to the innate immunity in plants.

198 ecular link between thermosensory growth and immunity in plants.

199 tinued circulation in wild birds and limited immunity in the human population.

200 We report a lack of cross-genotype immunity in the largest cohort of people to date.

201 nes and how they may influence pathology and immunity in the upper genital tract.

202 site of attack is essential for preinvasive immunity; in postinvasive immunity, the encasement of pa

203 lays a paramount role in mammalian antiviral immunity including direct targeting of viruses and their

204 translation in response to pattern-triggered immunity induction through interaction with poly(A)-bind

205 insights into the intricate germline-somatic-immunity interaction landscape.

206 Immunity, intestinal barrier function, host metabolism a

207 se findings provide a mechanism for adaptive immunity involvement in the kidney defect in sodium hand

208 -avidity epitope SSIEFARL induced protective immunity irrespective of gene expression context.

209 , we used IAV to investigate how host innate immunity is activated.

210 This lack of anti-tumour immunity is attributed to an absence of cell surface maj

211 Mucosal immunity is considered important for protection against

212 Adaptive immunity is driven by the expansion, somatic hypermutati

213 omaterials for the enhancement of anticancer immunity is given, including the perspectives of deliver

214 Adaptive cellular immunity is initiated by antigen-specific interactions b

215 elective for TH 2 immunity as TH 1 and TH 17 immunity is largely unaffected.

216 However, loss of immunity is not universal; some key functional responses

217 f a chronic infection in which antimicrobial immunity is protective in the vast majority of infected

218 Therefore, the biological role of CCRL2 in immunity is still unclear.

219 Central to CD8(+) T cell-mediated immunity is the recognition of peptide-major histocompat

220 ytotoxic function, the role of which in lung immunity is unclear.

221 In this issue of Immunity, Liew et al. (2017) reveal a critical role for

222 ses, including the gene-silencing and innate immunity machineries.

223 s corroborated previous findings that innate immunity may be involved in the progression of PTSD, yet

224 of nonmedical vaccine exemptions and waning immunity may have had on the resurgence of pertussis in

225 ggesting that NK cells, but not HCV adaptive immunity, may contribute to HCV viral control following

226 trix protein upregulated in asthma by type 2 immunity mediators.

227 flammatory response essential for functional immunity.MicroRNAs (miR) are important regulators of gen

228 and use maternal viral e antigen to educate immunity of the offspring to support its persistence aft

229 The effect of previous immunity on incidence was also investigated with a dynam

230 g our experimental model, impact of adaptive immunity on S. aureus colonisation could be assessed.

231 munity, enhance previously existing systemic immunity or re-target responses to the mucosae.

232 wn to produce antigenic peptides in adaptive immunity, our findings demonstrate its new role in produ

233 ens Consistent with the established effector-immunity paradigm for antibacterial T6SS substrates, the

234 of various human developmental, disease, or immunity pathways.

235 riving the disease progression in the innate immunity pathways.

236 activation, as it links innate and adaptive immunity, promoting potent B cell responses.

237 ere we make progress by studying the colicin immunity protein Im9.

238 to neighboring bacteria and produce specific immunity proteins that protect against self-intoxication

239 erties that improve SseB-mediated protective immunity provided by circulating memory.

240 Neu5Gc in Homo likely had complex effects on immunity, providing greater capabilities to clear sublet

241 MPs to trigger cell death and PAMP-triggered immunity (PTI) independent of their enzymatic activity i

242 eptors (PRRs) and activate pattern-triggered immunity (PTI).

243 neurovascular regulation through the innate immunity receptor CD36 (cluster of differentiation 36),

244 Tumor exosomes are emerging as antitumor immunity regulators; however, their effects on secondary

245 r findings provide a detailed information on immunity-related DEGs and reveal the potential of P. xyl

246 The mouse immunity-related GTPase (IRGM1) was overexpressed in emb

247 s, and a wide variety of innate and adaptive immunity-related proteins.

248 liver effectors into plant cells to suppress immunity-related signaling.

249 57BL/6 mice, but the mechanism of protective immunity remains undefined.

250 Mucosal immunity remodeled with increased in anti-inflammatory c

251 Thus, understanding how sex impacts immunity requires the elucidation of complex interaction

252 17 cells compromise antiviral and antifungal immunity, respectively, explaining the infectious suscep

253 nfection decreases humoral and cell-mediated immunity responses to hepatitis B vaccination is still c

254 aling, and sugar allocation related to plant immunity, revealing the complex nature of SSR resistance

255 In this issue of Immunity, Riffelmacher et al. (2017) show that autophagy

256 In this issue of Immunity, Shan et al. (2017) highlight that effector-to-

257 wever, part of the effect was caused by herd immunity, since vaccinated infants were more likely to b

258 In this issue of Immunity, Spath et al. (2017) show that the dysregulated

259 at we have described as maternal educational immunity such that by young adulthood, all immune cells

260 ovel inborn error of innate and/or intrinsic immunity that causes impaired (ds)RNA sensing, reduced I

261 utionarily conserved arms of cell-autonomous immunity that restrict replication of intracellular path

262 al for preinvasive immunity; in postinvasive immunity, the encasement of pathogen structures inside h

263 ie Metchnikoff and the discovery of cellular immunity, the phagocytic clearance of cellular debris ha

264 (HNSCC) and biomarkers that predict altered immunity, thereby enabling personalized treatment.

265 od1 and Nod2 proteins contribute to adaptive immunity, this study investigated their role in alloanti

266 MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple targe

267 apia mince hydrolysate (TMH) enhanced innate immunity through induction of IL-1beta and COX-2 express

268 out of the context of the infection, innate immunity to a DeltaICP0 virus was largely compromised, a

269 ure to a previous pandemic strain stimulates immunity to a pandemic strain identified decades later.

270 This is potentially problematic, since prior immunity to a scaffold may inhibit immune responses to t

271 plant systemic acquired resistance and basal immunity to bacterial pathogen infection.

272 clearance and generated species-transcending immunity to blood-stage malaria in mice.

273 cells have an established role in protective immunity to Bordetella pertussis, but this evidence is b

274 accine in 24 healthy adults, with or without immunity to CMV and vaccinia virus (previous DryVax smal

275 tivating inflammasomes that are important in immunity to cytosolic bacteria, DNA viruses, or HIV.

276 T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen.

277 ses multiple pathways to harness host innate immunity to enhance its replication.

278 Our data indicate that naturally occurring immunity to HSV-2 may be protective against infection wi

279 te mechanisms whereby HIV impairs protective immunity to M. tuberculosis, we evaluated the frequency,

280 play an essential role in naturally acquired immunity to malaria.

281 This is believed to undermine immunity to other pathogens and to accelerate immunosene

282 ggesting that a deeper understanding of host immunity to these viruses may lead to enhanced strategie

283 efit little from high surrounding population immunity to transmission and will sustain transmission a

284 ORC1 downstream of TBK1 in control of innate immunity, tumorigenesis, and disorders linked to chronic

285 multiple 'targeted' inhibitors on antitumor immunity, underscoring the complex effects resulting fro

286 IgA nephropathy targeting intestinal mucosal immunity upstream of disease manifestation.

287 antial effects on chronic pathology, natural immunity, vaccine development strategies, immune disorde

288 In this issue of Immunity, Van Braeckel-Budimmir et al. (2017) reveal tha

289 addition to disease resistance, the costs of immunity vary between individuals with different life-hi

290 We found that impairment of humoral immunity was most outspoken in the first year after lung

291 ggest that a sufficiently high level of herd immunity was reached during the first wave.

292 Postinvasive immunity was shown to limit pathogen growth in the epith

293 n for DENV vaccines on the basis of cellular immunity, we wanted to compare the cellular immune respo

294 rences to the adult in nearly all aspects of immunity, which at least partially explain the increased

295 f antipneumococcal antibody-mediated mucosal immunity while informing vaccine development.

296 lasticity and longevity to provide long-term immunity while other effector cells develop into termina

297 istent infection model to study heterologous immunity with LCMV.

298 ociated stroma (TAS) to configure protective immunity within the tumor microenvironment.

299 ced innate immune response and lack adaptive immunity, would be susceptible to the infection and deve

300 In this issue of Immunity, Zhu et al. (2017) report that tumor-associated