ライフサイエンスコーパス: immunity (against|to)

1 s the first capable of generating protective immunity against a broad spectrum of lethal pathogen cha

2 eatment-induced) does not confer sterilizing immunity against a future infection.

3 al immune responses and conferred protective immunity against a lethal challenge dose of homologous i

4 toxicity in animals and achieved protective immunity against a lethal influenza challenge seven mont

5 those of human bnAbs, and conferred complete immunity against a mixture of simian-human immunodeficie

6 t CD8(+) T cells are required for protective immunity against a naturally occurring murine pathogen t

7 , is required for both pre- and postinvasive immunity against a nonadapted powdery mildew fungus (Blu

8 In the wake of an epidemic, established immunity against a particular disease can limit spread a

9 These findings indicate that immunity against a particular HCV genotype does not offe

10 ed whether alpha-GalCer generates protective immunity against a swine influenza (SI) virus infection

11 consensus vaccines induce superior levels of immunity against a wide divergence of influenza subtypes

12 out of the context of the infection, innate immunity to a DeltaICP0 virus was largely compromised, a

13 ure to a previous pandemic strain stimulates immunity to a pandemic strain identified decades later.

14 This is potentially problematic, since prior immunity to a scaffold may inhibit immune responses to t

15 s and their consequences for cell-autonomous immunity to a wide variety of microbial pathogens.

16 optimally activating a CD4+ T cell-mediated immunity against actinic keratoses and, potentially, can

17 lipid raft cholesterol that regulates innate immunity to adenovirus in endosomes.IMPORTANCE Early reg

18 ermine how this interaction regulates innate immunity to adenovirus.

19 uction site for cytotoxic T lymphocyte (CTL) immunity to airborne pathogens and intranasal vaccines.

20 particularly ones that may provide long-term immunity against all four serotypes.

21 tory-based therapies to enable host-mediated immunity to assist in the detection and eradication of C

22 insights regarding mechanisms of protective immunity against B. mallei and B. pseudomallei, includin

23 tter establish surrogates of antigen-induced immunity against B. pseudomallei as well as provide valu

24 Although both OGs and macerozyme-induced immunity to B. cinerea in Col-0, only OGs also induced i

25 ification during infection is higher and the immunity to B. cinerea is compromised in pmei10, pmei11,

26 RM cells in immunity to B. pertussis Natural immunity to B. pertussis induced by infection is conside

27 ned the role of respiratory CD4 TRM cells in immunity to B. pertussis Natural immunity to B. pertussi

28 structure (MARCO) promotes protective innate immunity against bacterial and parasitic infections; how

29 inding protein 1 (NOG1), functions for plant immunity against bacterial pathogens.

30 plant systemic acquired resistance and basal immunity to bacterial pathogen infection.

31 ine/threonine kinase that provides efficient immunity against bacteriophages by inducing abortive inf

32 ight into where AIDS vaccines should produce immunity to be the most effective.

33 hetic enzymes as a means to strengthen plant immunity against biotrophic pathogens.

34 clearance and generated species-transcending immunity to blood-stage malaria in mice.

35 cells have an established role in protective immunity to Bordetella pertussis, but this evidence is b

36 e towards M1 macrophages for reactivation of immunity against breast cancer.

37 We believe this is first study of functional immunity to C. jejuni in chicken and shows antibody is i

38 e valuable tools to shape and drive cellular immunity against cancer and intracellular infection.

39 ophages are used clinically, e.g., to induce immunity against cancer.

40 purpose to promote adaptive T cell-mediated immunity against cancer.

41 rs IL-12p70 and IL-23 are important for host immunity against Candida spp.

42 This process may impair protective immunity against certain opportunistic infections with p

43 lack GP1 N-linked glycans provided effective immunity against challenge with ma-EBOV or a more distan

44 ults confirm the central role of antibody in immunity to chlamydia reinfection, and demonstrate a key

45 Natural infection induces partial immunity to Chlamydia trachomatis Identification of chla

46 onstrated a significant role for antibody in immunity to chlamydial infection.

47 To provide protective immunity against circulating primary HIV-1 strains, a va

48 ed apoptosis in mediating effector-triggered immunity to circumvent pathogen inhibition of immune sig

49 umans are likely to have limited preexisting immunity to CIV-H3N2 and that CIV-H3N2 x pdmH1N1 reassor

50 As natural immunity to clade B arises early in life, we hypothesize

51 wn 3- to 6-month lag in recovery of specific immunity to CMV after initiating cART and suggest that "

52 accine in 24 healthy adults, with or without immunity to CMV and vaccinia virus (previous DryVax smal

53 AS infection requires cell- and Ab-mediated immunity to control acute and persistent infection, resp

54 MV) persists in most humans, requires T cell immunity to control, yet tissue immune responses remain

55 ever, there is a lack of clear correlates of immunity to Ct infection in humans.

56 the specific roles of IL-1 elements in host immunity to cutaneous viral infection remain elusive.

57 tivating inflammasomes that are important in immunity to cytosolic bacteria, DNA viruses, or HIV.

58 Subjects with no preexisting immunity to DENV developed neutralizing antibodies to al

59 her, these findings suggest that preexisting immunity to DENV may impact protective immune responses

60 Our data indicate that immunity to DENV might drive greater ZIKV replication an

61 When subjects with preexisting immunity to DENV were vaccinated, they developed higher

62 eading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD)

63 Initiation of TH1 immunity to dietary antigen was dependent on interferon

64 T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen.

65 the specific microbes that elicit protective immunity to different infections is less clear.

66 entage was Foxp3(+), resulting in equivalent immunity to direct immunization.

67 nt parasites play a vital role in protective immunity against disease pathology upon reinfection thro

68 icited robust humoral, mucosal, and cellular immunity against diverse virus strains.

69 about the cross-reactivity of cell-mediated immunity against drifted strains in children.

70 edary-derived viruses, suggesting population immunity against dromedary viruses.

71 e that IL-17A is an important effector of MG immunity to E. coli and suggest that an early increased

72 amental role for TSLP and Th2 cells in tumor immunity against early-stage cancers.

73 lar requirements for robust and long-lasting immunity against EBV infection.

74 ed and whether the recipient has preexisting immunity to EBV but can be as high as 20%.

75 ed sensor has numerous other advantages like immunity to electromagnetic interference, fast response,

76 sor possesses additional advantages such as, immunity to electromagnetic interference, low cost, capa

77 This does not induce broad, cross protective immunity against emergent subtypes.

78 ses multiple pathways to harness host innate immunity to enhance its replication.

79 or further understanding how HCV evades host immunity to establish persistence.

80 We manipulate in vivo resources and immunity to explain interactions between two rodent mala

81 Th17 cell responses orchestrate immunity against extracellular pathogens but also underl

82 Bacteria and archaea employ adaptive immunity against foreign genetic elements using CRISPR-C

83 asitic infections; however, its role in host immunity against fungal pathogens, including the major h

84 homeostasis is a prerequisite to protective immunity against gastrointestinal infections.

85 T cell immunity to GroEL (BPSL2697) was specifically impaired i

86 e that IL-25 is critical for host protective immunity against H. polygyrus bakeri infection, highligh

87 cteristic Th2 effector functions and provide immunity to H. polygyrus Through selective deletion of I

88 We previously described CD4(+) T-cell immunity against HBsAg and polymerase in chimpanzees aft

89 BsAg) sometimes develop humoral and cellular immunity to HBV proteins such as core and polymerase tha

90 a novel antiviral mechanism in liver innate immunity against HCV infection and provide insights to s

91 sRNAs-induced intracellular antiviral innate immunity against HCV, suggesting the potential applicati

92 nce hepatocyte-mediated intracellular innate immunity against HCV.

93 necessary for the development of protective immunity to helminth parasites but also cause the inflam

94 y, patients who already had high preexisting immunity to HER2-ICD did not respond to therapy with inc

95 andidates to examine induction of protective immunity against heterologous pathogens.

96 ially that delivered via CD40, raised robust immunity against HIV-1 as measured by monitoring potenti

97 olypropylene sulfide nanoparticles to induce immunity against HIV-1.

98 ne profile to potentially induce more robust immunity against HIV.

99 s in HIV cure and prevention and in boosting immunity against HIV.

100 ovel correlates and mechanisms of protective immunity to HIV vaccination, thus offering a glimpse of

101 ble virus replication, indicating protective immunity against homologous strains.

102 (DENV-1-4) is thought to result in lifelong immunity to homotypic reinfection (ie, reinfection with

103 p16 with Ad.alphaPD1 could improve antitumor immunity against HPV-related tumors and that p16 may enh

104 Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin

105 Our data indicate that naturally occurring immunity to HSV-2 may be protective against infection wi

106 s are critical components of vaccine-induced immunity to human immunodeficiency virus type 1 (HIV-1)

107 an pulmonary endothelium possesses intrinsic immunity to human influenza viruses, in part due to the

108 at wanes over time; or 3) full but temporary immunity against HZ.

109 stalk of IBV contribute to cross-protective immunity to IBV of both lineages.

110 lic GMP-AMP synthase is essential for innate immunity against infection and cellular damage, serving

111 mlo12 triple mutant plants exhibit complete immunity against infection by otherwise virulent obligat

112 Induction of B-cell immunity against infection depends on the initiation of

113 mmatory caspases and pyroptosis in mediating immunity to infection and clearance of pathogens.

114 gammadelta T cells play a role in protective immunity to infection at mucosal surface, but also media

115 eting needs for maternal-fetal tolerance and immunity to infection is an important research and clini

116 al details of gammadeltaT cell antimicrobial immunity to infection remain largely unexplored.

117 Such conditioning may have evolved to allow immunity to infection while limiting subsequent autoimmu

118 s by promoting mechanisms that dampen innate immunity to infection.

119 T cells provide protective immunity against infections by differentiating into effe

120 ously unappreciated role of H2-O (HLA-DO) in immunity to infections may suggest new approaches in ach

121 hylactic vaccines provide protective humoral immunity against infectious agents, vaccines that elicit

122 One of these functions is to contribute to immunity against infectious diseases, but dysregulation

123 l motility are essential for adaptive T-cell immunity against infectious pathogens and cancers.

124 ported across the placenta can provide vital immunity against infectious pathogens for infants.

125 Immunity to infectious agents involves a coordinated res

126 structural resistance to the environment and immunity to infectious agents.

127 to understand population-level exposure and immunity to infectious diseases.

128 4(+) T cells in helping B cells and inducing immunity against influenza virus.

129 various types of infections, but its role in immunity to influenza A virus (IAV) is not well studied.

130 Molecular understanding of serological immunity to influenza has been confounded by the complex

131 wever, the mechanisms by which aging impacts immunity to influenza lung infection remain unclear.

132 d help us better understand how differential immunity to influenza skews immune responses toward coin

133 responses; however, humans have preexisting immunity to influenza viral antigens, particularly antib

134 e candidates in humans that have preexisting immunity to influenza.

135 d pTreg cells, and repress underlying strong immunity to ingested protein antigens.

136 ratio and lower detection limits, along with immunity against interference factors like ascorbic acid

137 generation and prevented protective humoral immunity to intestinal helminth infection.

138 Immunity to intestinal helminth infections has been well

139 Immunity to intestinal helminth infections requires the

140 mmunity is considered optimal for protective immunity against intracellular Ags.

141 s play critical roles in innate and adaptive immunity against intracellular pathogens.

142 otoxic T cells) are major cells that provide immunity against intracellular pathogens.

143 in mammals) is indispensable for intestinal immunity against invading bacteria.

144 To acquire CRISPR-Cas immunity against invasive mobile genetic elements, proka

145 t DCs are dispensable as APCs for protective immunity against LCMV infection.

146 CD11c(+) cells phenocopies enhanced adaptive immunity to Leishmania.

147 B/Bris att candidate stimulated sterilizing immunity against lethal homologous challenge and complet

148 nterestingly, vDeltaK1L conferred protective immunity against lethal VACV challenge.

149 ed immmunopathology in lung, yet sterilising immunity to lethal dose WT challenge was achieved after

150 Taken together, PRELP enhances host innate immunity against M. catarrhalis through increasing compl

151 investigate the effect of vitamin D on host immunity to M. tuberculosis in the context of the granul

152 mbination of the 2 vaccines yielded stronger immunity to M. tuberculosis infection.

153 d in immune regulation; however, its role in immunity to M. tuberculosis is unknown.

154 te mechanisms whereby HIV impairs protective immunity to M. tuberculosis, we evaluated the frequency,

155 dendritic cells help CD4(+) T helper 1 cell immunity against malaria through PD-L2's competition wit

156 Our results support the hypothesis that immunity to malaria is a higher-order phenomenon related

157 Acquired immunity to malaria is inefficient, even after repeated

158 Whole-sporozoite vaccines confer sterilizing immunity to malaria-naive individuals by unknown mechani

159 play an essential role in naturally acquired immunity to malaria.

160 lood cell play an important role in clinical immunity to malaria.

161 onally variant targets of naturally acquired immunity to malaria.

162 t contributes to the development of clinical immunity to malaria.

163 eover, APOBEC-3s are involved in host innate immunity against many viruses.

164 3 (CXCR3) chemokine pathway promotes T cell immunity to many viral pathogens, but its importance in

165 ONY treatment induced effective long-lasting immunity against MB49 cancer cells.

166 Immunity to measles and receipt of PEP was determined fo

167 ls many physiological processes ranging from immunity to memory.

168 Immunity against microbes depends on recognition of path

169 Helminth infections inhibit host immunity against microbial pathogens, which has largely

170 ogy of SP and its effect on immune cells and immunity to microbial infection.

171 e findings will provide insight into natural immunity to Mtb and will guide development of novel vacc

172 n that has been shown to control host innate immunity to Mtb infection.

173 eed the threshold correlated with protective immunity against multiple strains of Zika virus.

174 Moreover, IFN-lambda-mediated sterilizing immunity against murine norovirus requires the capacity

175 NO and TLR9 are important elements of innate immunity to mycobacteria, and these features of bdMphi b

176 CD4 T cells are critical for protective immunity against Mycobacterium tuberculosis (Mtb), the c

177 t previous disease results in less-effective immunity against Mycobacterium tuberculosis (Mtb).

178 udy, we investigated lactational transfer of immunity to Mycobacterium tuberculosis in MHC class I-mi

179 ulosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has bee

180 We studied the induction of adaptive immunity to neonatal infection with a murine retrovirus,

181 Survival was associated with enhanced T cell immunity to nine of fifteen immunodominant antigens anal

182 f DNA methylation and demethylation in plant immunity against nonviral pathogens.

183 TEM cells associated with strong protective immunity against ocular herpesvirus infection and diseas

184 +) T cells associated with strong protective immunity against ocular herpesvirus infection and diseas

185 ons confer serotype-specific protection, and immunity against other serotypes develops only after sub

186 ng if oral vaccination provides non-specific immunity to other infections so that the consequences of

187 ll axis may also have broad implications for immunity to other microbial infections and cancers, wher

188 This is believed to undermine immunity to other pathogens and to accelerate immunosene

189 This model may be relevant to understanding immunity to other persistent pathogen infections.

190 These results suggest that protective immunity against P. falciparum can be achieved via multi

191 egulators that we successfully implicated in immunity to P. capsici.

192 Immunity to P. falciparum declined prior to 2004, preced

193 The first layer of immunity against pathogenic microbes relies on the detec

194 I proteins initiates CD8(+) T cell-mediated immunity against pathogens and cancers.

195 MRA cells have been implicated in protective immunity against pathogens such as dengue virus (DENV).

196 play an important role in promoting mucosal immunity against pathogens, but the mechanistic basis fo

197 pertoire and cell state to provide effective immunity against pathogens.

198 GI tract and for establishing local adaptive immunity against pathogens.

199 egulate multiple immune responses, including immunity to pathogens and tumors, allergic inflammation,

200 candidate nuclear factors that may underpin immunity to pathogens in crops.

201 mer has primarily been implicated in passive immunity to pathogens while the latter mediates host-com

202 emory CD4 T cells are critical for effective immunity to pathogens, the mechanisms underlying their g

203 Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis a

204 rs of daughter cells necessary for effective immunity to pathogens.

205 lay critical roles in immune homeostasis and immunity to pathogens.

206 ce points to their role in the regulation of immunity to pathogens/tumors and in autoimmune/metabolic

207 interference-mediated silencing of pixr, or immunity against PIXR in mice, impairs the ability of B.

208 frequently in humans lacking robust adaptive immunity to Plasmodium falciparum Nevertheless, the host

209 The germplasm with immunity to PM are good sources of resistance for PM res

210 ression of GAE1 and GAE6 in Arabidopsis, and immunity to Pma ES4326 was compromised in gae6 and gae1

211 r pneumococcal colonization or that acquired immunity to pneumococci is an accumulation of individual

212 neously generates potent systemic antitumour immunity against poorly immunogenic B16F10 in the skin.

213 e detection of absorption, provides inherent immunity to power fluctuations, calibration-free operati

214 rain boundaries (</=15 degrees ) have better immunity to precipitation and grain boundary acid attack

215 rientations near to {100} have potential for immunity to precipitation and grain boundary acid attack

216 Plants depend on innate immunity to prevent disease.

217 abundant TEM and TRM will necessarily erode immunity to previously encountered pathogens as the resu

218 ge migration inhibitory factor regulate host immunity to promote parasite persistence.

219 ticular HCV genotype does not offer expanded immunity to protect against subsequent infections with a

220 via Relish2 in Ae. aegypti, as prophylactic immunity to protect mosquitoes during the vulnerable sta

221 response to cell stress and activate innate immunity to provide a pivotal mechanism by which an orga

222 ls and natural killer cells of cell-mediated immunity to provide tumor (B16-ova-Melanoma) protection

223 ine gradients that are essential for mucosal immunity against pulmonary bacterial pathogens.

224 thogens, but its importance in CD8(+) T cell immunity to recurrent herpes has been poorly elucidated.

225 ggest that eosinophils promote host cellular immunity to reduce influenza virus replication in lungs,

226 ERBs with MARV induces long-term protective immunity against reinfection and indicates that other fa

227 4 TRM cells play a critical role in adaptive immunity against reinfection and memory induced by natur

228 Mucosal immunity to reinfection with a highly virulent virus req

229 and prevents development of potent adaptive immunity to reinfection.

230 l blood-stage malaria or develop sterilizing immunity to reinfections.

231 Additionally, pre-existing immunity to related flaviviruses could generate cross-re

232 ons about the strength of naturally acquired immunity against rotavirus gastroenteritis (RVGE), mirro

233 ) has previously been shown to confer robust immunity against RSV infection in mice, cotton rats, and

234 Immunity to rubella virus (RV) is commonly determined by

235 sults as positive and (ii) the definition of immunity to RV as the 10-IU/ml usual cutoff as well as t

236 r understand the requirements for protective immunity against S. aureus.

237 IL-10 deficiency in mice restores protective immunity to S. aureus infection, and adjuvancy with a st

238 n infection, we show that lack of protective immunity to S. aureus systemic reinfection is associated

239 es, all of which are associated with natural immunity against Salmonella In vaccinated mice, a signif

240 reatment developed subsequent heterosubtypic immunity against secondary virus infection.

241 ria and archaea to acquire sequence-specific immunity against selfish genetic elements such as viruse

242 015, we estimated vaccine-induced population immunity against serotype-2 poliomyelitis for 1 January

243 Immunity against serotype-2 poliomyelitis was forecasted

244 of these NP adjuvants in inducing protective immunity against simian immunodeficiency virus (SIV).

245 ogical observations have long indicated that immunity against SM is acquired relatively rapidly, but

246 at a distant site leads to robust antitumor immunity against spontaneous breast carcinogenesis in mi

247 acquired anti-LTA Abs rescue TLR2-dependent immunity to staphylococcal LTA in individuals with inher

248 Humans do not usually develop effective immunity to Staphylococcus aureus reinfection.

249 th the batA mutant strain elicits protective immunity against subsequent infection with wild-type bac

250 tussis is thought to result in 4-20 years of immunity against subsequent symptomatic pertussis infect

251 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis.

252 pecific antibody fails to generate antitumor immunity against syngeneic B16F10 tumors in mice.

253 fector cells, which are essential in vaccine immunity against systemic dimorphic fungi.

254 We put forward the hypothesis that sustained immunity to T. gondii requires repeated antigenic stimul

255 SS provides the potential to elicit humoral immunity to target Plasmodium at multiple stages of its

256 -directed therapy aimed at manipulating host immunity against TB.

257 e may provide insight into protective T cell immunity to TB.

258 In addition, the protective immunity against the cysts remains largely unknown.

259 bidopsis thaliana BAG6 is required for basal immunity against the fungal phytopathogen Botrytis ciner

260 n for RIG-I like receptor in regulating host immunity against the live attenuated West Nile virus (WN

261 n for RIG-I-like receptor in regulating host immunity against the NS4B-P38G vaccine.

262 represent an early warning to activate host immunity against the pathogen.

263 Human innate immunity against the veterinary pathogen Trypanosoma bru

264 long-lived cellular and neutralizing humoral immunity against the viral hemagglutinin.

265 unctional SARD4 is required for proper basal immunity to the bacterial pathogen Pseudomonas syringae

266 ic status, body mass index, season, baseline immunity to the challenge virus, affectivity, and childh

267 mine the contribution of B cells and humoral immunity to the control of TB in nonhuman primates durin

268 R from flax (Linum usitatissimum) conferring immunity to the flax rust fungus.

269 While immunity to the infecting serotype is long-lived, hetero

270 Because a major cause of failure is lack of immunity to the infecting virus in a naive donor, more r

271 parasite Leishmania major, while conferring immunity to the intestinal trematode Schistosoma mansoni

272 atment with mAb to IL-10 restored protective immunity to the mutant mice.

273 complex protein Nup88/MOS7 is essential for immunity to the necrotrophic fungus Botrytis cinerea The

274 e examined the role of gammadelta T cells in immunity to the respiratory pathogen Bordetella pertussi

275 the wider population, presumably due to herd immunity against their seasonal H1 antigen.

276 Immunity to these infections is dependent on the ability

277 ogy approaches could enhance intrinsic cross-immunity to these paramyxoviruses and approaches to cont

278 ggesting that a deeper understanding of host immunity to these viruses may lead to enhanced strategie

279 The Sr35 resistance gene confers immunity against this pathogen's most virulent races, in

280 efit little from high surrounding population immunity to transmission and will sustain transmission a

281 This includes maintaining high population immunity to transmission up until OPV13 cessation, meeti

282 rast, many therapeutic strategies to augment immunity against tumors have focused predominantly on st

283 Memory CD8(+) T cells confer long-term immunity against tumors, and anticancer vaccines therefo

284 es in several autoimmune diseases or promote immunity to tumors.

285 activation gene-3 (LAG-3) signals to improve immunity to tumors.

286 ect of CD4(+) T cells in inducing protective immunity to vaccination with a T-dependent influenza vir

287 f efficacy as well as mechanisms controlling immunity to vaccination.

288 in antigen induction of humoral and cellular immunity against viral challenges.

289 ette (ABC) transporter essential to cellular immunity against viral infection.

290 e to look for variants that provide enhanced immunity against viral infection.

291 e SPL-IKKepsilon-IFN axis during host innate immunity against viral infection.

292 oth positive and negative regulators of host immunity to virus infection.

293 ntegration of selective autophagy into plant immunity against viruses and reveal potential viral stra

294 first infection confers long-term protective immunity against viruses of the infecting serotype, a se

295 ll and antibody ID despite its importance in immunity to viruses and other pathogens.

296 -Cas systems that confer microorganisms with immunity to viruses are present in only 10% of 1,724 sam

297 est new approaches in achieving neutralizing immunity to viruses.

298 id and high-throughput method for evaluating immunity to VZV.

299 ress has been made in characterizing humoral immunity to Zika virus (ZIKV) in humans, little is known

300 and 4 serotypes suggesting that pre-existing immunity to Zika virus could potentially enhance infecti