ライフサイエンスコーパス: immunodominant epitope

1 r of memory CD8 T cells (specific to the two immunodominant epitopes).

2 a vaccine expressing the same Ag without its immunodominant epitope.

3 the recombinant EspA filaments forming a new immunodominant epitope.

4 ingle amino acid modification, I129V, in the immunodominant epitope.

5 the S protein (residues 528-635) is a major immunodominant epitope.

6 eactivity, suggesting the destruction of the immunodominant epitope.

7 cells also failed to induce tolerance to an immunodominant epitope.

8 mains, and there was no evidence of a single immunodominant epitope.

9 acterial activity while safely expelling the immunodominant epitope.

10 s approaching those of CTLp specific for the immunodominant epitope.

11 7-negative EL4 cells develop CTL only to one immunodominant epitope.

12 he fate of this peptide from a cryptic to an immunodominant epitope.

13 s recognizing virion protein 22 aa 49-57, an immunodominant epitope.

14 n highly focused on a very limited number of immunodominant epitopes.

15 ar or higher avidity than those specific for immunodominant epitopes.

16 ation with T Ag-expressing cells lacking the immunodominant epitopes.

17 pe VII collagen, the domain known to contain immunodominant epitopes.

18 y when self-tolerance limits the response to immunodominant epitopes.

19 ic mice that are centrally tolerant to these immunodominant epitopes.

20 cept one of these regions was encoded within immunodominant epitopes.

21 y landscape in favor of MHC I complexes with immunodominant epitopes.

22 ed from human and swine HEV contain the same immunodominant epitopes.

23 class II molecules and included most of the immunodominant epitopes.

24 can distort the capture of the physiological immunodominant epitopes.

25 an important influence on the generation on immunodominant epitopes.

26 esponse is to create vectors that lack these immunodominant epitopes.

27 ssed HLA class II molecules and knowledge of immunodominant epitopes.

28 ffectively compete with T cells specific for immunodominant epitopes.

29 oligoclonal and focused on a small number of immunodominant epitopes.

30 the cellular and humoral immune responses to immunodominant epitopes.

31 he size of the CD8(+) T cell response to two immunodominant epitopes.

32 rnary epitopes and V1/V2-mediated masking of immunodominant epitopes.

33 a and directed against three promiscuous and immunodominant epitopes.

34 Donors reacted to diverse immunodominant epitopes.

35 st both virally encoded and tumor-associated immunodominant epitopes.

36 tivity, Ins1 B5-14 and Ins1/2 A2-10 were the immunodominant epitopes.

37 ered a fusion protein of mouse IgG1 with the immunodominant epitope 12-26 from bacteriophage lambda c

38 To identify immunodominant epitopes, 33 peptides overlapping human t

39 essive effector memory CTLs specific for the immunodominant epitope 40-48 of myelin oligodendrocyte g

40 Epitope mapping of LipC identified 6 immunodominant epitopes, 5 of which map to the exposed s

41 Nevertheless, a polymorphism in the immunodominant epitope #7 (S73T) showed a 56-99% reducti

42 Five immunodominant epitopes accounted for more than half of

43 the production of peptides encompassing the immunodominant epitope and destruction of the subdominan

44 c CD4+ T cells are directed against a single immunodominant epitope and exist independently of Ab res

45 may serve to amplify the CTL response to the immunodominant epitope and prevent the emergence of immu

46 r data indicate that E6 aa48-57 contains the immunodominant epitope and that a CRT/E6 DNA vaccine may

47 suggest that iB-1 is an immunogenic but not immunodominant epitope and that anti-iB-1 antibodies do

48 responses to rLACK are skewed away from the immunodominant epitopes and are diversified to include t

49 lt in impaired CD8 T cell responses to known immunodominant epitopes and decline in heterosubtypic im

50 Progress in defining the immunodominant epitopes and how neutralizing antibodies

51 nactivated SARS-CoV recognized the two major immunodominant epitopes and one antigenic site located a

52 Those moieties represent the immunodominant epitopes and the most functional ones.

53 eleted or mutated to alanine, eliminated the immunodominant epitope, and we used this information to

54 of memory CD8 T cells to only one of the two immunodominant epitopes, and p75R deficiency had a minim

55 t epitopes, the 32-kDa protein contained two immunodominant epitopes, and the 16-kDa protein containe

56 onymous/synonymous mutations and encompassed immunodominant epitopes, and their locations were not es

57 echanisms for class II-mediated selection of immunodominant epitopes are complex and differ for each

58 Immunodominant epitopes are few selected epitopes from c

59 Immunodominant epitopes are known to suppress a primary

60 Autoantigen-derived immunodominant epitopes are resistant to digestion by ca

61 eral blood of human subjects and to identify immunodominant epitopes associated with viral infection.

62 he Leishmania major LACK antigen contains an immunodominant epitope at amino acids 156 to 173 (LACK(1

63 ecombinant OGDC-E2 was judged to express the immunodominant epitope, because when sera from patients

64 This immunodominant epitope bound stably to DQ2.2.

65 he amplification of the CTL response to this immunodominant epitope, but also to the recognition of f

66 trates that a single amino acid change in an immunodominant epitope can eliminate an immune response

67 nduced CD8(+) T-cell responses against three immunodominant epitopes can increase the incidence of el

68 The immunodominant epitope, CII (186-192), contains a QGPRG

69 MBP residues 111-129 compose an immunodominant epitope cluster restricted by HLA-DRB1*04

70 nalysis revealed a minimal determinant of an immunodominant epitope, comprising critical residues at

71 at these responses are heterogeneous with no immunodominant epitopes consistently recognized.

72 Located within a single CP subunit is an immunodominant epitope consisting of residues 169 to 180

73 we have shown that the regions flanking the immunodominant epitope constitute a portable motif that

74 oci restricted the dominant regions, and the immunodominant epitopes could be predicted using bioinfo

75 and transient exposure of non-neutralizing, immunodominant epitopes could hinder the induction of br

76 ed CD8+ T cells, including those recognizing immunodominant epitopes, decline with combination therap

77 Efficient presentation of an immunodominant epitope derived from glutamate decarboxyl

78 mice with bioactive CpG ODN combined with an immunodominant epitope derived from herpes simplex virus

79 lls indicated that nearly 20-fold more of an immunodominant epitope derived from kappa L chains was b

80 linical trial data in mice, we introduced an immunodominant epitope derived from ovalbumin (OVA; SIIN

81 DC increased cross-presentation of E75, the immunodominant epitope derived from the HER2 protein, an

82 Here, we have identified an immunodominant epitope derived from the S. typhimurium G

83 tope V is weakly cross-presented relative to immunodominant epitopes derived from the same protein Ag

84 In this study, we show that two immunodominant epitopes derived from the tumor Ags (TAs)

85 eceptor retinoid binding protein or with its immunodominant epitope encoded by residues 161-180.

86 unctionality, whereas those specific for the immunodominant epitope exhibit increased functionality i

87 We recently identified the immunodominant epitope for polyoma virus-specific CTL as

88 We previously identified the immunodominant epitope for polyoma virus-specific CTL in

89 This epitope has been termed the immunodominant epitope for the FVB/N mouse, but we propo

90 to 62 of Hsp20, which contained one or more immunodominant epitopes for each animal.

91 vant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive

92 opulation of CD8(+) T cells specific for the immunodominant epitope formed by H-2Db and the influenza

93 Phosphocholine (PC) is the immunodominant epitope found on the surface of Streptoco

94 xicity against the immunizing peptides or an immunodominant epitope from an influenza recall antigen.

95 ers containing a peptide corresponding to an immunodominant epitope from human GAD65 were used to ana

96 d carboxyl-terminal extension containing the immunodominant epitope from influenza hemagglutinin anti

97 The in vitro binding of an immunodominant epitope from the myelin basic protein (MB

98 approximately 85% of cells specific for the immunodominant epitope from the viral matrix (M) protein

99 and memory TCR repertoires for each of three immunodominant epitopes from lymphocytic choriomeningiti

100 Unlike most pathogens, many of the immunodominant epitopes from Mycobacterium tuberculosis

101 s on and responds to very few representative immunodominant epitopes from pathogenic insults.

102 topes that can be as strong as those seen in immunodominant epitopes from the "conventionally process

103 II-restricted processing and presentation of immunodominant epitopes from the major house dust mite a

104 MEFA-6) which incorporates all of the major immunodominant epitopes from the seven functional region

105 D8(+) T cell responses of cattle against two immunodominant epitopes from Theileria parva (Tp1(214-22

106 human cells specific for OspA(165-184), the immunodominant epitope, from five DRB1*0401(+) patients,

107 The immunodominant epitope, gD (362-370), was identified wit

108 blood and mucosal tissues, with responses to immunodominant epitopes generally shared by both sites;

109 The four immunodominant epitopes have been tested for immunogenic

110 thermore, this vaccination approach subverts immunodominant epitope hierarchies by enhancing response

111 Immunodominant epitopes highly conserved across genotype

112 T cell tolerance to the H-2-D(b)-restricted immunodominant epitope I of T Ag by 6 mo of age, before

113 We found a single, highly immunodominant epitope in 46% (23/50) of the donors.

114 the CD8(+) T cell response specific for the immunodominant epitope in C57BL/6 mice, derived from gly

115 nocytogenes or vaccinia virus expressing the immunodominant epitope in C57BL/6 mice.

116 We have identified an immunodominant epitope in citrullinated alpha-enolase, t

117 mpatibility complex (MHC) protein I-Au is an immunodominant epitope in experimental autoimmune enceph

118 e early CTL response was focused on a highly immunodominant epitope in gp 160, there was rapid elimin

119 similar, indicating that MT(389-397) is the immunodominant epitope in H-2k mice.

120 These results indicate that the immunodominant epitope in PLA2R is exclusively located i

121 n the brain even when those reactive with an immunodominant epitope in Tat are lost from the rest of

122 121-130 presented in the context of Db is an immunodominant epitope in TMEV infection and that the fr

123 ts to the importance of internal residues as immunodominant epitopes in (1-->2)-beta-mannans and to t

124 ein specifically recognized multiple, unique immunodominant epitopes in autologous tumor idiotype.

125 Whether the immunodominant epitopes in B95.8 are shared in virus fro

126 inst factor VIII are mainly directed against immunodominant epitopes in C2, A3, and A2 domains.

127 We studied the CD8(+) T cell response to six immunodominant epitopes in five HIV-infected subjects us

128 es, and HLA tetramer binding against defined immunodominant epitopes in gag, pol, env, and nef as wel

129 ein (PLP) 175-192, that are considered to be immunodominant epitopes in HLA-DR4 individuals.

130 peptide pool demonstrates a pivotal role for immunodominant epitopes in the generation of a clonal re

131 These findings implicate immunodominant epitopes in the pathology of ANCA-associa

132 Furthermore, CTLs to some of the immunodominant epitopes involve highly conserved T cell

133 core shells with an antibody specific to the immunodominant epitope is compared to the constructs wit

134 dicated that, like serum autoantibodies, the immunodominant epitope is directed against the inner lip

135 The immunodominant epitope is DRB1-restricted and was observ

136 tive Darwinian selective pressure against an immunodominant epitope is presented.

137 d modulation of effector T cells specific to immunodominant epitopes is a central issue in autoimmune

138 The PPI/PI immunodominant epitope LALEGSLQK was localized at the C-

139 The mapped 12-amino acid immunodominant epitope lies within a "hinge" region betw

140 EBA autoantibodies recognize four major immunodominant epitopes localized within the amino-termi

141 Two major immunodominant epitopes located in the C-terminal region

142 ain these epitopes but lack the variable and immunodominant epitopes located in the globular head of

143 g without limiting virus viability, and also immunodominant epitopes located in variable regions.

144 ominant epitope and prevent the emergence of immunodominant epitope-loss viruses and virus-induced tu

145 This immunodominant epitope may be a uniquely accessible surf

146 according to the binding motif of the human immunodominant epitope MBP 85-99 and the binding pockets

147 Its immunodominant epitope, MBP 85-99, forms a complex with

148 ern that the combination of several normally immunodominant epitopes might result in a new hierarchy

149 We show that ANT1 encompasses multiple immunodominant epitopes (namely, ANT1 21-40, ANT1 31-50,

150 A single Db-restricted immunodominant epitope (NP(366)) was previously known in

151 amma-producing CD8+ T cells specific for the immunodominant epitope NS3-1073 in 26 of 30 mice (86%) t

152 s optica (NMO) patients, which recognize the immunodominant epitope of aquaporin-4, exhibit Th17 pola

153 y using a human T-cell line specific for the immunodominant epitope of Bet v 1 and in vivo in an adju

154 mer covalently loaded with OspA(164-175), an immunodominant epitope of Borrelia burgdorferi.

155 Mapping of the immunodominant epitope of E6 revealed that an E6 peptide

156 Specifically, an immunodominant epitope of EV71 that maps to the virus ca

157 nerated TCR transgenic NOD mice for a second immunodominant epitope of GAD65, peptide 206-220 (G206).

158 Both TCR are responsive to an immunodominant epitope of glutamic acid decarboxylase 65

159 t viral replication through targeting of the immunodominant epitope of group-associated antigen (Gag)

160 Interestingly, the display of the immunodominant epitope of HEL, 106-116/E(d), and of a do

161 terminal residues, Trp62/63, which flank the immunodominant epitope of hen egg lysozyme (HEL 52-61),

162 nses to the COOH-terminal PFR of the H-2A(k) immunodominant epitope of hen egg lysozyme (HEL) 52-61.

163 HLA-DR53 and H-2Ek, extensive mimicry of the immunodominant epitope of HLA-DR53 by several carcinogen

164 ctively to a synthetic peptide containing an immunodominant epitope of HuCOAg (peptides 69-83).

165 racterisation of the genetic basis of a key, immunodominant epitope of meningococcal LPS.

166 me(v+/-)) and B10.PL wild-type mice with the immunodominant epitope of myelin basic protein (MBP Ac1-

167 on the nature of the anchor residues of the immunodominant epitope of myelin basic protein (MBP) 85-

168 Amino acid residues 111-129 represent an immunodominant epitope of myelin basic protein (MBP) in

169 An immunodominant epitope of myelin basic protein (MBP), VH

170 , we demonstrated that analog peptides of an immunodominant epitope of myelin basic protein (residues

171 The immunodominant epitope of OspA for T helper cells was id

172 The immunodominant epitope of OspA in the context of HLA-DRB

173 tested a "worst case" scenario in which the immunodominant epitope of OVA (SIINFEKL) and its in vitr

174 ronal hnRNP A1 is contained within the human immunodominant epitope of tax and suggests that molecula

175 f CD8(+) T cells that recognize the Tax11-19 immunodominant epitope of Tax protein expressed by human

176 nia in which antibody is directed against an immunodominant epitope of the beta3 (glycoprotein IIIa [

177 t recombinant L. monocytogenes expressing an immunodominant epitope of the LCMV glycoprotein (GP33) w

178 h frequency of CD4+ T cells specific for the immunodominant epitope of the viral hemagglutinin (HA) p

179 In addition to an immunodominant epitope of the viral nucleoprotein (NP) t

180 CD8(+) T cell immunodominant epitopes of alpha-NAC were mapped by appl

181 These results demonstrate that immunodominant epitopes of carefully selected M. tubercu

182 cted autoreactive CD4(+) T cells recognizing immunodominant epitopes of Dsg3 initiate the production

183 s of eight SMS patients recognised different immunodominant epitopes of GAD65 compared with T cells f

184 tigen receptor (TCR) specific for one of the immunodominant epitopes of GAD65, peptide 286-300 (G286)

185 Determination of immunodominant epitopes of MHC class I-restricted self-A

186 the antibody response and suggested that the immunodominant epitopes of OspC reside in the variable d

187 tive immunity is not necessarily directed at immunodominant epitopes of pathogens and may be improved

188 Interestingly, the immunodominant epitopes of PDC-E2, BCOADC-E2, and OGDC-E

189 ead consistent with periodic turnover of the immunodominant epitopes of PfEMP1 associated with severe

190 ells specific for the three H2(b)-restricted immunodominant epitopes of T-Ag.

191 The immunodominant epitopes of the 30- and 32-kDa proteins i

192 The immunodominant epitopes of these major extracellular pro

193 used overlapping sets of peptides to map the immunodominant epitopes of this autoantigen.

194 ully identified the physiologically selected immunodominant epitopes of two model antigens: hemagglut

195 V)-specific CD8 T cells recognize a strongly immunodominant epitope on glycoprotein B (gB498) and can

196 ce, activated CD8(+) T cells specific for an immunodominant epitope on HSV-1 glycoprotein B (gB-CD8 c

197 ice, half of these cells are specific for an immunodominant epitope on HSV-1 glycoprotein B, whereas

198 that this immune response is directed at an immunodominant epitope on the bacterial surface.

199 dy the specificity of the CTL response to an immunodominant epitope on the dengue virus NS3 protein.

200 Antibodies reactive with an immunodominant epitope on the F glycoprotein of this vir

201 I occurs as a result of the expression of an immunodominant epitope on the P2 molecule.

202 E-1 TAAs to investigate presentation of this immunodominant epitope on the surface of a variety of ca

203 The BclA protein is the immunodominant epitope on the surface of Bacillus anthra

204 maintain a 1:1 ratio of cells recognizing an immunodominant epitope on viral glycoprotein B (gB498-50

205 gineered FVIII molecules has further defined immunodominant epitopes on FVIII and may provide a thera

206 chronic graft loss; thus, identification of immunodominant epitopes on major histocompatibility comp

207 ker of HIV-1-ITP elicited due to exposure of immunodominant epitopes on talin-H as a result of a dise

208 nal and monoclonal antibodies indicated that immunodominant epitopes on the capsid protein as well as

209 In this study, we identified two major immunodominant epitopes on the M protein located in the

210 209 through 276, indicating that one or more immunodominant epitopes on Topo I is located between ami

211 rating encephalitogenic T cells specific for immunodominant epitopes on various myelin proteins that

212 s infection is often focused on one or a few immunodominant epitopes, one approach to circumvent this

213 e lambda repressor cI sequence p1-102 or its immunodominant epitopes (p12-26, p73-88) can be elicited

214 of MHC class I molecules in complex with two immunodominant epitopes (PA(224-233)/D(b) and PB1(703-71

215 Specifically, the amino-terminal immunodominant epitope, peptide 5 (P5), stimulates stron

216 -) mice were expanded in the presence of the immunodominant epitope present in the MHV transmembrane

217 line immunodeficiency virus (FIV) comprising immunodominant epitopes present in the third variable do

218 ered antigen processing and the hierarchy of immunodominant epitope presentation.

219 nown to bind to M3 molecules, fMIGWII is the immunodominant epitope presented by M3 during infection

220 unodominance effect, whereby the presence of immunodominant epitopes prevents recognition of nondomin

221 ed target cells coated with two of the three immunodominant epitopes previously defined for LCMV (gly

222 Among the HPV6-specific sera there was no immunodominant epitope recognized by all sera.

223 An immunodominant epitope recognized by anti-topo I autoant

224 In addition, 26D1 epitope is immunodominant epitope recognized by both antibodies eli

225 We now show that the immunodominant epitope recognized by CD4+ Th cells from

226 We previously identified TB10.4(20-28) as an immunodominant epitope recognized by H2-K(d)-restricted

227 specific for listeriolysin O (LLO)91-99, the immunodominant epitope recognized by H2-Kd-restricted T

228 Since there is not one immunodominant epitope recognized by most hosts, strateg

229 nd the PDTRP fragment, which is a well-known immunodominant epitope recognized by several anti-MUC1 m

230 The mutated PPP1R3B peptide represents the immunodominant epitope recognized by tumor-reactive T ce

231 entameric B subunit of CT (CTB) contains the immunodominant epitopes recognized by antibodies that ne

232 virus (HIV) escape mutations often arise in immunodominant epitopes recognized by MHC class I allele

233 Here, we identified the immunodominant epitope region in PLA2R by probing isolat

234 elated with overall sequence homology, and 2 immunodominant epitope regions of Phl p 12 were identifi

235 rity of dominant over subdominant responses, immunodominant epitopes represent the preferred vaccine

236 Eight (72%) of 11 recognized > or =1 immunodominant epitope, representing either a new or an

237 The elimination of the immunodominant epitope response also eliminated the resp

238 or residue, thereby abrogating activation of immunodominant epitope responses.

239 e presented by this allele, and suggest that immunodominant epitopes restricted by common HLA alleles

240 Mutational analysis of the immunodominant epitopes revealed that single amino acid

241 hat memory CD8 T cells specific for a single immunodominant epitope (S436 or S525) substantially prot

242 This report, therefore, indicates that immunodominant epitopes should be defined, not only by t

243 K288S/Y176F, a variant mutated in one of the immunodominant epitopes, showed reduced antigenicity.

244 The vaccine-elicited immunodominant epitope-specific CD8(+) T lymphocyte resp

245 The availability of immunodominant epitope-specific CTL capable of recognizi

246 sed by virus isolates to mutate away from an immunodominant epitope-specific CTL response are not wel

247 oss-presentation coupled with competition by immunodominant epitope-specific T(CD8) contributes to th

248 These results showed that P5 contains an immunodominant epitope specifically associated with DTH

249 of the previously defined HLA-A2-restricted immunodominant epitope SSX-2(41-49).

250 ur-TCR-Tg]) expressing a TCR recognizing the immunodominant epitope (Sur20-28) of murine survivin dur

251 duced frequency of T cells responding to the immunodominant epitope Talpha146-162 indicating a degree

252 suggesting that circulating viruses may lack immunodominant epitopes targeted through HLA-A2.

253 s revealed flanking residues proximal to the immunodominant epitope that increased the production and

254 ctural and immunobiological definition of an immunodominant epitope that is a candidate immunogen for

255 N specifically inhibited the response to two immunodominant epitopes that are known to be dependent o

256 mor cells is to identify and slightly modify immunodominant epitopes that elicit T-cell responses.

257 Moreover, the immunodominant epitopes that were most discriminatory be

258 thogen has made it difficult to characterize immunodominant epitopes that would allow the identificat

259 The 30-kDa protein contained nine immunodominant epitopes, the 32-kDa protein contained tw

260 e was shifted from the previously identified immunodominant epitope to a novel epitope when the antig

261 with the non-immunodominant peptide enabled immunodominant epitopes to induce T-cell activation (p=0

262 ocytes to secrete cytokines or present viral immunodominant epitopes to virus-specific T cells.

263 jor histocompatibility complex (MHC) class I immunodominant epitopes using an overlapping peptide scr

264 dent increase in the surface exposure of the immunodominant epitope (V86-T98) as determined by antibo

265 An immunodominant epitope, VV-e7r130, did not generate cros

266 T-cell IFN-gamma immunity to OprF and its immunodominant epitopes was characterized.

267 the number of mutations within HBV core gene immunodominant epitopes was lower at TW28 and was negati

268 ost and parasite may be responsible for this immunodominant epitope, we screened for antibody-reactiv

269 Antibodies specific for the immunodominant epitope were raised in rabbits or were pu

270 Specific responses against an immunodominant epitope were seen using IFN-gamma ELISPOT

271 human leukocyte antigen (HLA) restriction of immunodominant epitopes were defined using HLA class II

272 One to 3 major cN1A immunodominant epitopes were identified.

273 Several minor immunodominant epitopes were reactive with about 50% of

274 Immunodominant epitopes were the most efficacious in lon

275 epitopes are Tc2, in contrast to CTL for the immunodominant epitope, which are of the Tc1 type.

276 clonal, polymeric IgA antibody that binds an immunodominant epitope within the O-antigen (O-Ag) compo

277 designated as pML-MIT3, that coexpresses the immunodominant epitopes within the three distinct lipoyl