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1 hielding other sites that might otherwise be immunogenic.
2 t A. terreus conidia were significantly less immunogenic.
3 aged 50-65 years and found it to be safe and immunogenic.
4 idates rendered RSV overattenuated or poorly immunogenic.
5 re simultaneously aggregation prone and auto-immunogenic.
6 Both vaccination regimens were immunogenic.
7 HSPs), in the extracellular environment, are immunogenic.
8 cated more efficiently in vivo, and was more immunogenic.
9 tly expressed, the secreted pre-F was poorly immunogenic.
10 says, they have been considered to be poorly immunogenic.
11 G/MVA-CMDR HIV-1 vaccine regimen is safe and immunogenic.
12 ed that the syngenic mouse iPSC lines can be immunogenic.
13 acteria used in mouse colonizations from the immunogenic 33-mer gluten peptide were characterized by
15 cularly rapid variation was observed at some immunogenic accessory loci, including a phage protein an
17 hese studies, rVSV-ZEBOV was reactogenic but immunogenic after a single dose and warrants further eva
18 ce, while MVvac2-H2 additionally proved more immunogenic after a single, human-range dose in genetica
19 lous bacteria and the fact that these highly immunogenic Ags seem to be actively released during in v
20 ssing (TEIPP) constitute a novel category of immunogenic Ags that are selectively presented on transp
21 n and Extavia, which are reported to be more immunogenic among IFNbeta products in clinical usage, co
22 ecific epitope mismatches known to be highly immunogenic and (2) immunosuppressive minimization in pa
23 ic transcriptomic signature characterized by immunogenic and a metabolic aberrations, indicating that
25 njugate vaccines (Vi-conjugate vaccines) are immunogenic and can be used from infancy but there are n
26 hallenged with NFM15-35 Although NFM15-35 is immunogenic and cross-reactive with MOG at the polyclona
27 nt on a safe, well-tolerated vaccine that is immunogenic and deployable in regard to manufacturing, s
29 id spike containing a serine in this loop is immunogenic and elicits antibodies that neutralize all H
32 a protein-nanoparticle is significantly more immunogenic and gives significantly better transmission-
33 rated with synthetic mRNA (TriMixDC-MEL) are immunogenic and have antitumor activity as a monotherapy
35 ecroptosis-deficient cancer cells are poorly immunogenic and hence escape natural and therapy-elicite
36 ed FP and SF derived MSCs and examined their immunogenic and immunomodulatory properties before and a
37 S2 conjugated to diphtheria toxoid is highly immunogenic and induces Abs that recognize and neutraliz
38 vaccine candidate is expected to be safe and immunogenic and is available for clinical development.
40 spite the observations that BB0405 is poorly immunogenic and not recognized during mouse or human inf
42 Delta170) vectors, the F1 virus was the most immunogenic and protective against wt RSV challenge.
45 imal-derived glycoproteins are also strongly immunogenic and rabbit ATG induces serum sickness diseas
46 y in cotton rats, the candidates were highly immunogenic and reduced RSV loads in both the upper and
48 AHSV serotypes, taking into account not only immunogenic and safety properties but also virus product
50 AS03B-adjuvanted H5N1 influenza vaccine was immunogenic and showed an acceptable safety profile in a
51 s that two different pathways of activation, immunogenic and tolerogenic, induce different changes in
52 chanisms faces many challenges including the immunogenic and toxic effects of these non-natural syste
54 neurovirulence of the virus, but it remained immunogenic, and a single immunization protected mice ag
57 ccine candidate, DB1, was attenuated, highly immunogenic, and protective against RSV challenge in cot
59 ruses represent an excellent option as safe, immunogenic, and protective live-attenuated vaccines.
60 ndid#1 is a safe, genetically stable, highly immunogenic, and protective vaccine candidate against Bo
62 sed sites not previously identified as being immunogenic, and this increase is significantly greater
63 (1) squamous; (2) pancreatic progenitor; (3) immunogenic; and (4) aberrantly differentiated endocrine
64 n enabling strong immune responses to poorly immunogenic antigens, via display on multimerisation sca
66 le inactivated virus vaccines (WIVs) were as immunogenic as seasonal WIVs, as they induced similar le
67 different glycosylation patterns and is more immunogenic, as evidenced by the induction of higher tit
69 ally, pyocins are stable in the lung, poorly immunogenic at high concentrations and efficacy is maint
70 We demonstrate that in BALB/c mice R21 is immunogenic at very low doses and when administered with
79 and we predicted SPAG5 and TSSK6 as putative immunogenic cancer/testis antigens in multiple cancers.
80 d conjugates of a native siderophore and the immunogenic carrier protein cholera toxin subunit B (CTB
84 ve provided new insight into the identity of immunogenic CD1 antigens and the mechanisms that control
85 y in syngeneic mice through the induction of immunogenic cell death (ICD) as well as interfering in t
88 ccinia virus VVWR-TK(-)RR(-)-Fcu1 can induce immunogenic cell death and generate a systemic immune re
89 ecessor Delta-24-RGD, Delta-24-RGDOX induced immunogenic cell death and recruit lymphocytes to the tu
91 ng of NSCLC cells but also elicited signs of immunogenic cell death including an endoplasmic reticulu
93 ical evidence indicates that the capacity of immunogenic cell death to (re-)activate an anticancer im
94 uppression in the TME and induction of tumor immunogenic cell death, leading to activation and expans
95 cell death pathways have emerged, including immunogenic cell death, necroptosis, pyroptosis, and net
100 We show that HBsAg-AS01 induces a distinct immunogenic cellular signature within the blood and drai
101 d when oncolytic treatment was combined with immunogenic chemotherapy or with immune checkpoint block
102 y of cancer immunotherapy, radiotherapy, or 'immunogenic' chemotherapy by leveraging responses to tum
103 rveillance that continuously eliminates many immunogenic clones, resulting in lower clonal heterogene
104 eading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis.
106 nhance vaccine efficacy by generating a more immunogenic CSP-based particle vaccine and therefore dev
107 t that certain chemotherapeutic drugs elicit immunogenic danger signals in dying cancer cells that ca
108 fits and disadvantages of methods to recover immunogenic DB and inactivate contaminating viral partic
112 ovel myelin-specific therapy that works with immunogenic DCs, hence without the in vivo conversion co
113 unfit for normal hematopoiesis but prone to immunogenic death, leading to neutrophil extracellular t
114 ever, previous studies have shown that these immunogenic designer peptides are not always effective.
115 er, a naturally occurring deletion within an immunogenic domain is present at high frequencies in Afr
116 T cell immunity when appropriately selected immunogenic drugs (e.g., oxaliplatin combined with cyclo
119 s a surface-exposed membrane antigen that is immunogenic during spirochete infection, despite the gen
122 ins in bread is important to avoid potential immunogenic effects of undigested peptides, including fo
126 RSV F expressed from the pre-N position was immunogenic, eliciting complement-independent RSV-neutra
127 amed airways can lose tolerance over time to immunogenic entities released on frequent eosinophil deg
128 at barrier sites where constant exposure to immunogenic environmental agents may induce destructive
130 ids so that it is homologous with a known H3 immunogenic epitope sequence significantly improved the
131 s can also explain amino acid preferences in immunogenic epitopes and highlight opportunities for str
132 QVPDPNVPDAFVVIADR(156),are found to be major immunogenic epitopes that are localized on the outer sur
136 struct appears to be suitably attenuated and immunogenic for further development as a bivalent intran
140 that RNA:DNA hybrids may represent a common immunogenic form of nucleic acids in AGS and provide the
141 se its stability in the pre-F form, the most immunogenic form that elicits highly functional virus-ne
142 ains, the domains do not rely on potentially immunogenic framework mutations and maintain the structu
145 We propose that aberrant accumulation of immunogenic GAD65 in Golgi membranes facilitates inappro
148 We have previously described promiscuous and immunogenic HLA-DR-restricted peptides derived from huma
149 as Pfs25-EPA/Alhydrogel(R) appeared safe and immunogenic, however, the level of Pfs25-specific antibo
150 conclusion, we identified an attenuated and immunogenic i.n. vaccine candidate expressing GP from th
156 Both candidate vaccines were attenuated and immunogenic in ferrets, inducing antibodies that neutral
159 ccines of H7N9 subtype are consistently less immunogenic in humans than vaccines developed for other
160 silico-predicted A2-binding ESO peptides are immunogenic in humans, namely those that have high pepti
163 l P2-VP8-P[8] vaccine was well tolerated and immunogenic in infants, providing a novel approach to va
165 remembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protectio
166 crotonate tautomerase (4-OT) family, was pro-immunogenic in mice when fused to a range of pathogen an
167 at have normal immune systems, but much less immunogenic in patients with hematologic malignancies wh
168 se PE38 is a bacterial protein, it is highly immunogenic in patients with solid tumors that have norm
171 that liver-resident CD103(+) DCs are highly immunogenic in response to hepatotropic viral infection
172 rified recombinant H7 HA appear to be poorly immunogenic in that they induce low levels of HI and MN
177 highly conserved and experimentally verified immunogenic influenza A epitopes as putative non-seasona
178 of allergies do not provide epitope specific immunogenic information and hence lack critical informat
180 ger RNAs (mRNAs) highly translatable and non-immunogenic is one such feature that directly implicates
182 f production of both surface and periplasmic immunogenic lipoprotein isoforms has possible implicatio
183 ch, we show for the first time that a highly immunogenic lipoprotein TP0435 can be differentially pro
184 he human immunodeficiency virus was bound to immunogenic liposomes for potent antibody generation for
185 of selecting and defining linear peptides as immunogenic markers of Cry1A(b)-type toxins in transgeni
186 mor immunity, as deletion of PD-L1 on highly immunogenic MC38 tumor cells allows effective antitumor
188 ith multiple recurrent lesions, where poorly immunogenic melanoma phenotypes were found to evolve in
189 ion and, further, establishes a long-lasting immunogenic memory, which determines disease severity of
190 hese issues, we focused on the use of highly immunogenic merozoite surface protein 8 (MSP8) as a vacc
192 n efficacious in a variety of cancer with an immunogenic microenvironment, but is associated with tox
196 eta/tau (AV-1953R) B cell epitopes, based on immunogenic MultiTEP platform and evaluate the immunogen
197 the VipA/B sheath was exploited to generate immunogenic multivalent particles for vaccine delivery.
200 ic T cell receptor (TCR) to target different immunogenic mutations in cyclin-dependent kinase 4 (CDK4
205 ave the potential to simultaneously identify immunogenic neoantigens and tumor-reactive T cell clonot
206 ated self-antigens and constitute a class of immunogenic neoantigens that are unmasked during tumor i
207 ent Food and Drug Administration approval of immunogenic oncolytic virus (OV) has opened a new era in
208 olymorphisms (SNPs) in the genes of 16 major immunogenic Ov proteins: Ov-CHI-1/Ov-CHI-2, Ov16, Ov-FAR
210 ct sizes and the often polymorphic nature of immunogenic parasite proteins make the robust identifica
211 dendritic cells effectively shuts down their immunogenic pathways and implicates transcriptional and
212 US-immunized C57BL/6J mice, we identified an immunogenic peptide within the mycobacterial ribosomal l
218 mbinant human factor H devoid of potentially immunogenic plant-specific sugar residues on protein N-g
219 within human insulin mRNA encoding a highly immunogenic polypeptide that is targeted by T cells in T
220 ctural motifs present in the core of the key immunogenic polysaccharide lipoarabinomannan (LAM).
221 Autophagy-deficient DCs exhibited reduced immunogenic potential and failed to prime autoantigen-sp
223 reveal new information on the antigenic and immunogenic potential of E2-based immunogens and provide
227 atography tandem mass spectrometry and their immunogenic potential was evaluated using peripheral blo
228 evant antigenic targets, regardless of their immunogenic potential, must be efficiently presented by
229 in target cells has the ability to increase immunogenic presentation of tumor Ags, which results in
230 elf-proteins in antigen-presenting cells are immunogenic, promoting cytokine production by the cells
231 subunit vaccines, a direct comparison of the immunogenic properties and protective efficacies of the
232 ype, while also retaining ligand binding and immunogenic properties indistinguishable from wild type,
233 ophagy, certain chemotherapeutic agents with immunogenic properties may enhance anti-tumor immunity b
236 ted to well-characterized viruses with known immunogenic/protective T-cell target antigens, precludin
239 e to growth regulation without expression of immunogenic proteins would be an important mechanism for
241 veloping, Ab responses against the two major immunogenic regions of the VlsE molecule in the human ho
243 rotected against PDA and was associated with immunogenic reprogramming of innate and adaptive immunit
244 cted against oncogenesis and phenocopied the immunogenic reprogramming of the tumour microenvironment
245 the tricarboxlyic acid cycle, as well as an immunogenic response consistent with increased tumor inf
246 rmacologic inhibition results in an enhanced immunogenic response leading to reduced tumor growth.
252 (iii) describe our efforts to make new less-immunogenic RITs by identifying and removing T- and B-ce
253 e potential for implementation of a safe and immunogenic RSV vaccine within the context of global hea
254 mismatches in HLA-DRB3, 4, and 5 are not of immunogenic significance after HLA 10/10 matched allogen
255 adly neutralizing antibodies to identify the immunogenic sites of a dominant viral antigen-the pentam
261 n aerobic sites and suppressed expression of immunogenic SPI-1 components contributes to the restrain
264 d transfusions from a single donor (a highly immunogenic stimulus), or until platelet refractoriness.
265 ing LPS as a ligand represented a pathogenic immunogenic stimulus, physical disruption of cell-cell c
266 e manner would provide an off-the-shelf, non-immunogenic strategy to improve clinical care of severe
268 aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA su
269 ic cells (DCs) promote either tolerogenic or immunogenic T cell responses, the latter upon sensing mi
270 D65 peptides presented by DC focus on highly immunogenic T cell targets, whereas HLA-DR-binding pepti
271 dulate their ability to prime tolerogenic or immunogenic T cells by expressing a core antigen present
272 eveloped without clear identification of the immunogenic targets expressed by human cancers in vivo.
274 high levels of genomic instability are more immunogenic than other cancers with a less extensive bur
276 cells is distinctly glycosylated and is more immunogenic than sE2 produced in mammalian cells, sugges
277 ealing therapeutics, as they are likely less immunogenic than the full-length protein and more conven
278 nhanced H expression were significantly more immunogenic than their parental strain in outbred mice,
283 STING incites spontaneous immunity during immunogenic tumor growth and accordingly, STING agonists
284 New evidence suggests that tumors express immunogenic, tumor-specific epitopes generated from the
285 y and demonstrated efficacy against a poorly immunogenic tumour, make CPMV an attractive and novel im
287 entify neoantigen quality as a biomarker for immunogenic tumours that may guide the application of im
291 x(CpG) adjuvant were identified as promising immunogenic vaccines for ongoing pre-clinical assessment
293 latory T cells was reprogrammed to eliminate immunogenic virus-induced tumor cells in response to CD1
297 topes in the gp120 V3 region that are highly immunogenic when SOSIP trimers are evaluated in animal m
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