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1 ins resides within an homologous, C-terminal immunoglobulin domain.
2 ound to IL-23 exclusively via its N-terminal immunoglobulin domain.
3 cause of specific substitutions in the first immunoglobulin domain.
4 s, each encoding half or a complete variable immunoglobulin domain.
5 polysialylation of N-glycans on the adjacent immunoglobulin domain.
6 polysialylation of N-glycans on the adjacent immunoglobulin domain.
7 o 104 of the N-terminal variable domain-like immunoglobulin domain.
8 interaction, predominantly through the first immunoglobulin domain.
9 d unfolding of a small protein with only one immunoglobulin domain.
10 aspase prodomains contain a death domain and immunoglobulin domains.
11 h structure of FN3 closely resembles that of immunoglobulin domains.
12 pre-TCR that lacked all of its extracellular immunoglobulin domains.
13 , a 45-55-kDa transmembrane protein with two immunoglobulin domains.
14 acellular portions of which consist of seven immunoglobulin domains.
15 the Z-disk of the sarcomere, is composed of immunoglobulin domains.
16 ne-bound gene containing three extracellular immunoglobulin domains.
17 soforms differing at any one of the variable immunoglobulin domains.
18 ing different combinations of three variable immunoglobulin domains.
19 diverse group of proteins composed solely of immunoglobulin domains.
20 e vertebrate protein composed solely of four immunoglobulin domains.
21 n such muscle, and contains tandem arrays of immunoglobulin domains.
22 om lepidopteran insects, is composed of four immunoglobulin domains.
23 and bioengineering of isolated antibody and immunoglobulin domains.
24 st in the PEVK-region and then in individual immunoglobulin domains.
26 nce tags in zebrafish we identified secreted immunoglobulin domain 4 (sid4), a gene encoding a solubl
27 This isoform consists of two extracellular immunoglobulin domains, a transmembrane domain and a cyt
29 omains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V dom
31 expression of the inhibitory receptor T cell immunoglobulin domain and mucin domain 3 (Tim-3) after s
33 ucine-rich repeats, a fibronectin domain, an immunoglobulin domain and short intracellular tails capa
34 resists forces much higher than the typical immunoglobulin domain and that the force distribution is
35 lular domain of TMIGD1 contains two putative immunoglobulin domains and mediates self-dimerization.
36 immunoglobulin superfamily containing three immunoglobulin domains and one fibronectin type III repe
37 t that N-CAM-N-CAM binding involves all five immunoglobulin domains and prompt the hypothesis that in
38 n cell-adhesion molecule (CAM) that contains immunoglobulin domains and regulates the EGFR signaling
39 inetics of multidomain protein constructs of immunoglobulin domains and the ability of different homo
40 eins corresponding to each of the individual immunoglobulin domains and the combined FnIII 1-2 and pr
41 a predicted transmembrane protein with five immunoglobulin domains and three fibronectin type III re
42 g of an extracellular region containing five immunoglobulin domains and two fibronectin type III (FnI
43 ar basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are m
45 f 282 amino acids with a signal sequence, an immunoglobulin domain, and a COOH-terminal hydrophobic t
46 een two cysteine residues resembling a V-set immunoglobulin domain, and another region containing a m
47 estral genes into those specifying bona fide immunoglobulin domains, and the generation of multiple c
48 erall fold and disposition of the two C2-set immunoglobulin domains are similar to the D1D2 domains o
49 y cDNA clones consists of V-type and C2-type immunoglobulin domains as well as a hydrophobic signal s
50 x with CAR (2.8 angstroms) reveal an unusual immunoglobulin-domain assembly for JAML and a charged in
52 d in the conformation of the four N-terminal immunoglobulin domains, because x-ray diffraction showed
54 bled with a TCRalpha mutant that lacked both immunoglobulin domains, but shortening of the TCRalpha c
55 like receptors (PIR), contain two additional immunoglobulin domains, but show strong sequence and fun
56 e limited to the relative disposition of the immunoglobulin domains C epsilon 3 and C epsilon 4 in Ig
57 The N-terminal binding site, consisting of immunoglobulin domains C1 and C2 connected by a flexible
58 sequence alone, in the absence of any other immunoglobulin domains, can mediate cardiolipin binding,
60 Because of its structural homology to the immunoglobulin domain, combinatorial libraries of FN3 de
61 on of CD27 or Fc receptor-like 4 (FCRL4), an immunoglobulin domain containing a receptor with strong
62 we examined the importance of the conserved immunoglobulin domain, containing the homophilic binding
65 the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two i
66 o their structural features: TIGIRR-1 (three immunoglobulin domain-containing IL-1 receptor-related)
67 nhibited in a dominant-negative manner by an immunoglobulin domain-containing palladin fragment lacki
68 We now show that SynCAM is a brain-specific, immunoglobulin domain-containing protein that binds to i
69 urther demonstrate that PMP22 interacts with immunoglobulin domain-containing proteins known to regul
70 ut not neurotrophin-3, selectively regulated immunoglobulin domain-containing splice variants of NRG,
72 trained conformation of the second and third immunoglobulin domains creates a binding site that is co
73 X-ray structures of the amino-terminal four immunoglobulin domains (D1-D4) of two distinct Dscam iso
74 alpha indicates that the mouse CD8alphaalpha immunoglobulin-domain dimer does not undergo significant
75 nteraction between SpA and the Fab-region of immunoglobulin domains encoded by the V(H)3 gene family
76 n of intimin comprises an articulated rod of immunoglobulin domains extending from the bacterium surf
77 The overall fold places it within the V-type immunoglobulin domain family and reveals close homology
78 rofascin molecules, all of which contain six immunoglobulin domains, five fibronectin repeats, a tran
80 dicating that the secondary structure of the immunoglobulin domain folds are preserved on complex for
81 ition states for folding of TI I27, the 27th immunoglobulin domain from human cardiac titin, and that
83 s, which resembles the N-terminal half of an immunoglobulin domain from the immense skeletal muscle p
84 nd quantify rare misfolding events in tandem immunoglobulin domains from the I band of titin under na
85 icity, by determining the properties of five immunoglobulin domains from the I-band in three differen
86 r dynamics simulation of force-induced titin immunoglobulin domain I27 unfolding led to the discovery
87 eplicated in BioVU, rs993312 in Sema domain, immunoglobulin domain (Ig), short basic domain, secreted
88 r homodimers mediated by the four N-terminal immunoglobulin domains (Ig1-4), arranged in a horseshoe
89 lation of two N-glycans located on the fifth immunoglobulin domain (Ig5) of NCAM requires the presenc
90 ymer that is added to N-glycans on the fifth immunoglobulin domain (Ig5) of the neural cell adhesion
92 REM-1) signaling (eg, CCL2, CCL3, and single immunoglobulin domain IL1R1 related [SIGIRR]) and IL-36
94 erefore illustrates the critical role of the immunoglobulin domain in regulation of the localization
95 able mechanical strength, similar to that of immunoglobulin domains in the giant muscle protein titin
97 s bound to N-CAM, and in solution all of the immunoglobulin domains inhibited the aggregation of N-CA
100 mutations in the Sns fibronectin-binding or immunoglobulin domains lead to morphologically abnormal
101 c cell surface molecule called Tim-3 (T cell immunoglobulin domain, mucin domain) has been identified
102 e T(H) type 1 (T(H)1)-specific Tim-3 (T cell immunoglobulin domain, mucin domain) protein functions t
103 ino terminus, a long stretch (>40) of tandem immunoglobulin domains, multiple tandem epidermal growth
104 ial N-linked glycosylation site in the first immunoglobulin domain of CD22 completely abrogates ligan
105 on motif Asp-Gly-Glu-Ala (DGEA) in the sixth immunoglobulin domain of CHL1, suggesting that CHL1 func
106 amer through direct interactions between the immunoglobulin domain of gp130 and site III of viral IL-
108 ion of purified N-CAM, the recombinant third immunoglobulin domain of N-CAM, or N-CAM antibodies eith
109 rystal structure of TIGIT bound to the first immunoglobulin domain of nectin-2 indicated that the rec
112 lular portion of PECAM, or of only the first immunoglobulin domain of PECAM, fused to the Fc portion
114 We also report the crystal structure of the immunoglobulin domain of TLT-1 determined at the resolut
116 r between the second and third extracellular immunoglobulin domains of fibroblast growth factor recep
118 Previously, we demonstrated that one of the immunoglobulin domains of palladin (Ig3) is both necessa
119 ave similar architectures, with the variable immunoglobulin domains of the heavy and light chain each
120 studied the unfolding by force of one of the immunoglobulin domains of the muscle protein titin using
121 long term evolution of these characteristic immunoglobulin domains over the 450 million years since
123 hrough junctional localization of the Alcama immunoglobulin-domain protein, which functions to restab
124 the zig gene family, which code for secreted immunoglobulin domain proteins required for maintaining
125 ide analysis of members of a small family of immunoglobulin domain proteins, we found that OIG-8, a p
127 This may be due to the loss of its native immunoglobulin domain structure or to the requirement fo
128 ution solution structure, which comprises an immunoglobulin domain that is intimately coupled to a no
129 ructure reveals a highly bent arrangement of immunoglobulin domains that form an extended convex surf
130 f the immunoglobulin superfamily, having six immunoglobulin domains, thirteen fibronectin repeats and
133 would be predicted to encode for at least 68 immunoglobulin domains, two fibronectin domains, one cal
135 exceptional preservation of their N-terminal immunoglobulin domains, which results in maintenance of
137 wo (D1-D2) or three (D0-D1-D2) extracellular immunoglobulin domains, with the D1 and D2 domain recogn
138 at both antibodies interacted with the third immunoglobulin domain within the extracellular region of
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