ライフサイエンスコーパス: immunoglobulin gene

1 receptor beta chain gene and the heavy chain immunoglobulin gene.

2 le exception of somatic hypermutation in the immunoglobulin gene.

3 tor for OCT factors during the activation of immunoglobulin genes.

4 biochemical mechanisms of diversification of immunoglobulin genes.

5 some cases carrying functionally inactivated immunoglobulin genes.

6 ic processes during somatic hypermutation of immunoglobulin genes.

7 with increasing rates of somatic mutation in immunoglobulin genes.

8 SHM) and class-switch recombination (CSR) of immunoglobulin genes.

9 ellular genes, including proto-oncogenes and immunoglobulin genes.

10 h recombination and somatic hypermutation in immunoglobulin genes.

11 tion (SHM) and class switch recombination of immunoglobulin genes.

12 se in mutations of C during hypermutation of immunoglobulin genes.

13 ion by PCR of a single or limited numbers of immunoglobulin genes.

14 on that links one c-myc allele to one of the immunoglobulin genes.

15 d induction of somatic cell hypermutation of immunoglobulin genes.

16 may participate in somatic hypermutation of immunoglobulin genes.

17 (OCA-B, OBF-1) to stimulate transcription of immunoglobulin genes.

18 issue- and stage-restricted transcription of immunoglobulin genes.

19 f polymerase chain reaction amplification of immunoglobulin genes.

20 primarily by rearrangement and expression of immunoglobulin genes.

21 ns result from the same process that targets immunoglobulin genes.

22 and undergo secondary V(D)J recombination of immunoglobulin genes.

23 may play a role in somatic hypermutation of immunoglobulin genes.

24 se that direct transcription from rearranged immunoglobulin genes.

25 ber tandem repeats and switch regions of the immunoglobulin genes.

26 ally regulated transcriptional activation of immunoglobulin genes.

27 mers for highly conserved regions of TCR and immunoglobulin genes.

28 amplifies the variable region repertoire of immunoglobulin genes.

29 ection from a phage display library of mouse immunoglobulin genes.

30 hallmarks of somatic mutation of endogenous immunoglobulin genes.

31 ermutation and class switch recombination of immunoglobulin genes.

32 s (GCs) to proliferate and hypermutate their immunoglobulin genes.

33 rocesses by deaminating cytosine residues in immunoglobulin genes.

34 quired affinity-enhancing mutations in their immunoglobulin genes.

35 inase (AID) deaminates cytosine to uracil in immunoglobulin genes.

36 s no physical evidence of uracil residues in immunoglobulin genes.

37 A (RPA), an AID cofactor, was restricted to immunoglobulin genes.

38 cholera vaccine were compared by analysis of immunoglobulin genes.

39 switch recombination, and gene conversion of immunoglobulin genes.

40 nd perhaps in somatic hypermutation (SHM) of immunoglobulin genes.

41 zing radiation or V(D)J recombination of the immunoglobulin genes.

42 II pauses or stalls during transcription of immunoglobulin gene, AID is likely to promote MCMs.

43 Though largely specific for immunoglobulin genes, AID also acts on a limited set of

44 Immunoglobulin gene analysis was unique and demonstrated

45 Transcription of the rearranged immunoglobulin gene and expression of the enzyme activat

46 Antibodies are encoded by the immunoglobulin genes and AID acts as a transcription-dep

47 switch recombination within their rearranged immunoglobulin genes and also participate in a number of

48 We sequenced the VH immunoglobulin genes and germline progenitors of two rat

49 6 patients with somatically mutated CLL-cell immunoglobulin genes and identified 2 patients with mult

50 on, including appropriate expression of both immunoglobulin genes and other early B-cell-restricted g

51 in loci; it can instigate DNA lesions in non-immunoglobulin genes and thus stringent checks are in pl

52 lated to ensure ordered recombination of the immunoglobulin genes and to avoid genomic instability.

53 sively differentiating cells, an analysis of immunoglobulin genes and transcripts indicated that pro-

54 is necessary for production of a functional immunoglobulin gene, and renders the cells highly sensit

55 Immunoglobulin genes are assembled during lymphoid devel

56 among which expressions of mitochondria and immunoglobulin genes are differentially perturbed in ped

57 f AID's promiscuity and its predilection for immunoglobulin genes are unknown.

58 opriate reference DNA enabled us to identify immunoglobulin genes as novel cancer targets playing a r

59 B lymphopoiesis requires that immunoglobulin genes be accessible to RAG1-RAG2 recombin

60 The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, lead

61 Rearrangement of T-cell receptor (TCR) and immunoglobulin genes by a common V(D)J recombination mac

62 Blimp-1 induced the transcription of immunoglobulin genes by controlling the 3' enhancers of

63 relies on the somatic diversification of the immunoglobulin genes by V(D)J recombination, somatic hyp

64 Somatic mutations of immunoglobulin genes characterize mature memory B cells,

65 iously known to be involved in mRNA editing, immunoglobulin gene class switching, and immunoglobulin

66 d that HGAL is dispensable for GC formation, immunoglobulin gene class-switch recombination, and soma

67 we have previously shown to hypermutate its immunoglobulin genes constitutively.

68 and this report addresses the nature of the immunoglobulin genes controlling the host antibody respo

69 damage induced sister chromatid exchange and immunoglobulin gene conversion are unaffected.

70 n by disruption of XRCC3 not only suppresses immunoglobulin gene conversion but also prevents the abe

71 t induce DSBs, (ii) defective in HR-mediated immunoglobulin gene conversion, and (iii) exhibit an inc

72 e (AID) converts DNA cytosines to uracils in immunoglobulin genes, creating antibody diversification.

73 unable to generate somatic hypermutations of immunoglobulin genes) displayed anti-nontypeable H influ

74 iters, but the role of ATM in antigen-driven immunoglobulin gene diversification has not been defined

75 AID is required for immunoglobulin gene diversification in B lymphocytes, bu

76 d deaminase, acting in the shared pathway of immunoglobulin gene diversification.

77 cific factor that deaminates DNA to initiate immunoglobulin gene diversification.

78 rporation of dUTP in DNA, and for increasing immunoglobulin gene diversity during the acquired immune

79 ns as the frequency of mutation in noncoding immunoglobulin gene DNA is the same in high- and low- af

80 function is to potentiate diversification of immunoglobulin gene DNA.

81 as the rearrangement of T-cell receptor and immunoglobulin genes during lymphoid development or the

82 beyond about 1 to 2 kb from the promoter of immunoglobulin genes during SHM must be due to special c

83 which leads to mutations at C:G basepairs in immunoglobulin genes during somatic hypermutation.

84 s of these xenoantibodies were compared with immunoglobulin genes encoding antibodies that react with

85 hat overexpress TCL1 under control of the mu immunoglobulin gene enhancer, develop a CD5+ B cell lymp

86 Allelic exclusion of immunoglobulin genes ensures the expression of a single

87 of B cells with a diverse representation of immunoglobulin genes, exhibiting antigen-driven positive

88 present an IFN response, cell proliferation, immunoglobulin gene expression, viral dose-dependent gen

89 Together, these data add to the selectin and immunoglobulin gene families a new inducible endothelial

90 tebrate major histocompatibility complex and immunoglobulin gene families.

91 s of evolution, involving random mutation of immunoglobulin genes followed by natural selection by T

92 may expand B cells carrying largely distinct immunoglobulin genes following antigenic challenge.

93 tion and the DNA cleavage events involved in immunoglobulin gene formation, and because Tn5-derived t

94 blood from the same patient showed that the immunoglobulin genes from both compartments had dominant

95 further tested these programs using 30 human immunoglobulin genes from Genbank and here highlight ins

96 Cloning of immunoglobulin genes from HA-specific B cells isolated f

97 By expressing immunoglobulin genes from individual cells, we identifie

98 gate revealed that they all used heavy-chain immunoglobulin genes from the V(H)3 family, two expresse

99 NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration.

100 Evidence for somatic hypermutation of immunoglobulin genes has been observed in all of the spe

101 ell diversification in patients with mutated immunoglobulin genes has not been previously presented.

102 Molecular analyses of immunoglobulin genes have delineated two or more subgrou

103 ures in HCL were examined in a series of 130 immunoglobulin gene heavy chain rearrangements, includin

104 L) with unmutated (U-CLL) or mutated (M-CLL) immunoglobulin gene heavy-chain variable region (IGHV) d

105 n-activated B-cell clones expand and undergo immunoglobulin gene hypermutation and selection.

106 particularly useful for analysing endogenous immunoglobulin gene hypermutation in several mouse strai

107 To test the hypothesis that immunoglobulin gene hypermutation in vivo employs a path

108 ng, immunoglobulin gene class switching, and immunoglobulin gene hypermutation.

109 ed apoptosis and suggest that members of the immunoglobulin gene (Ig) superfamily, like cell surface

110 h recombination and somatic hypermutation of immunoglobulin genes (Ig) in B lymphocytes.

111 ained from high-throughput DNA sequencing of immunoglobulin genes (Ig-seq) can be applied to detect B

112 on (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igkappa, and Iglambda).

113 se by activation of AID and hypermutation of immunoglobulin gene in B cells, leading to HCV-associate

114 S does not impact on the rate of mutation of immunoglobulin genes in B lymphocytes, suggesting that t

115 The c-myc gene is translocated to one of the immunoglobulin genes in Burkitt's lymphoma resulting in

116 in T-helper lymphocytes, and suppression of immunoglobulin genes in early stages of disease.

117 ypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during a

118 d undergo secondary diversification of their immunoglobulin genes in germinal centres (GCs).

119 ymphomagenesis has been inferred by studying immunoglobulin genes in human lymphomas and by engineeri

120 These genes catalyze the rearrangement of immunoglobulin genes in immature B lymphocytes and of T

121 e inferred to be copied by pol during SHM of immunoglobulin genes in mice.

122 argeted hypermutation of variable regions of immunoglobulin genes in response to stimulation by antig

123 Analysis of the repertoire of rearranged immunoglobulin genes in the B cells of microdissected fo

124 ductive V gene rearrangement, the functional immunoglobulin genes in the B lymphocytes of man and mou

125 in prokaryotes and by V(D)J recombination of immunoglobulin genes in vertebrates.

126 It has been postulated that certain immunoglobulin genes (including 2a2) are rearranged pref

127 Hypermutation of immunoglobulin genes is a key process in antibody divers

128 The expression of immunoglobulin genes is controlled in part by the DNA-bi

129 B-cell-specific transcription of immunoglobulin genes is mediated by the interaction of a

130 ypermutation mechanism is targeted solely to immunoglobulin genes is no longer tenable.

131 Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antib

132 tic hypermutation in the variable regions of immunoglobulin genes is required to produce high affinit

133 e propose that diversification of functional immunoglobulin genes is triggered by AID-mediated deamin

134 ion (CSR) and somatic hypermutation (SHM) of immunoglobulin genes, is essential for the removal of de

135 onstrated with antibody-deficient muMT mice (immunoglobulin-gene knockout mice), and CD4(+) spleen T

136 cells, AID deaminates cytosine in the DNA of immunoglobulin genes, leading to the accumulation of mut

137 ies hyperdiploidy or translocations into the immunoglobulin gene loci are considered as initiating ev

138 inging c-MYC into the vicinity of one of the immunoglobulin gene loci.

139 Thus, AID is required for all three immunoglobulin gene modification programs (gene conversi

140 namic programming method that uses conserved immunoglobulin gene motifs to improve performance of ali

141 with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T ba

142 ow a markedly reduced level of non-templated immunoglobulin gene mutation, indicating a defect in tra

143 notype and a post-germinal center pattern of immunoglobulin gene mutation.

144 status and presence of specific somatic and immunoglobulin gene mutations have been shown to be reli

145 h respect to clinical course and presence of immunoglobulin gene mutations in the CLL cells.

146 alter genomic sequence and structure at the immunoglobulin genes of B lymphocytes: gene conversion,

147 ell markers, such as expression of unmutated immunoglobulin genes or the zeta-associated protein of 7

148 liest jawed vertebrates possess a primordial immunoglobulin gene organization where each gene cluster

149 ion, class switching, and gene conversion in immunoglobulin genes, possibly via the spliceosome trans

150 Hypermutation in immunoglobulin genes produces a high frequency of substi

151 l as a reduction in mRNA levels of secretory immunoglobulin gene products such as mu(s) and J chain a

152 tions showed the highest frequency of clonal immunoglobulin gene products.

153 arget the somatic hypermutation process, the immunoglobulin gene promoter located upstream of the var

154 The B-cell lymphoma is monoclonal for immunoglobulin gene rearrangement and is phenotypically

155 for DNA double-strand break (DSB) repair and immunoglobulin gene rearrangement and may play a role in

156 nal center B cells creates the potential for immunoglobulin gene rearrangement and the generation of

157 Functional immunoglobulin gene rearrangement is a sine qua non for

158 This analysis also demonstrated that immunoglobulin gene rearrangement is less precise than p

159 machinery that is responsible for secondary immunoglobulin gene rearrangement, we examined the expre

160 cked at the progenitor B cell stage prior to immunoglobulin gene rearrangement.

161 on from B-0 (also known as B-2) occurs after immunoglobulin gene rearrangement.

162 mammalian DNA double-strand break repair and immunoglobulin gene rearrangement.

163 ssociated antigens (11/15), exhibited clonal immunoglobulin gene rearrangements (13/13), contained Ep

164 Both neoplasms contained clonal immunoglobulin gene rearrangements and clonal EBV genome

165 Hairy cells possess clonal immunoglobulin gene rearrangements and express monoclona

166 Molecular analysis detecting immunoglobulin gene rearrangements and ocular cytokine l

167 t microbes can induce specific signatures of immunoglobulin gene rearrangements and that pathogen exp

168 Analysis of immunoglobulin gene rearrangements and viral terminal re

169 ne conversion but also prevents the aberrant immunoglobulin gene rearrangements associated with RAD18

170 Immunoglobulin gene rearrangements document the monoclon

171 ents occur in developing macronuclei, as for immunoglobulin gene rearrangements in mammals, but not d

172 Analysis of immunoglobulin gene rearrangements indicated that the ly

173 Clonal CD27(+)ALDH(high) B cells, sharing immunoglobulin gene rearrangements with lymph node HRS c

174 ll antigen receptor through nested secondary immunoglobulin gene rearrangements, a process termed rec

175 nt is a highly ordered process that involves immunoglobulin gene rearrangements, antigen receptor exp

176 cillary testing included PCR for heavy chain immunoglobulin gene rearrangements, immunohistochemistry

177 Southern blot analysis for immunoglobulin gene rearrangements, terminal repeat anal

178 nds, and Rag1 is a transposase that mediates immunoglobulin gene rearrangements.

179 is that should occur following nonproductive immunoglobulin gene rearrangements.

180 ressed the transgene and excluded endogenous immunoglobulin gene rearrangements.

181 reaction for clone-specific T-cell receptor/immunoglobulin gene rearrangements.

182 We propose that secondary immunoglobulin-gene rearrangements outside organized lym

183 The data further suggest that selected immunoglobulin genes recognize specific protein structur

184 Immunoglobulin gene recombination can result in the asse

185 kage promotes interactions between c-myc and immunoglobulin gene regulatory elements that affect c-my

186 t tolerant of the DNA breaks associated with immunoglobulin gene remodeling mechanisms involved in th

187 , presumably due to bystander effects of the immunoglobulin gene remodeling that takes place at these

188 MBL and subsequent CLL and characterized the immunoglobulin gene repertoire of the prediagnostic B-ce

189 of the breast, but little is known about the immunoglobulin gene repertoire of these tumor-infiltrati

190 ic hypermutation and switch recombination of immunoglobulin genes require the activity of the activat

191 The establishment of allelic exclusion in immunoglobulin genes requires differential treatment of

192 re used to clone, sequence, and identify the immunoglobulin genes responsible for encoding rat xenoan

193 Single-cell immunoglobulin gene retrieval analysis shows that these

194 results may help explain the GC-richness of immunoglobulin gene segment joins (N regions) and the lo

195 mal cell and cytokine dependency, functional immunoglobulin gene segment rearrangement, and subsequen

196 nhairpin coding ends associated with various immunoglobulin gene segments in cells undergoing V(D)J r

197 R modules in agnathans (jawless fish) and of immunoglobulin gene segments in gnathostomes (jawed vert

198 eudogenes, and, additionally, 70 pseudogenic immunoglobulin gene segments.

199 mbination of extrachromosomal and endogenous immunoglobulin gene segments.

200 r circulating tumour DNA encoding the clonal immunoglobulin gene sequence could be detected in the se

201 Previous studies of immunoglobulin gene sequences in patients with allergic

202 metimes oncogenic) mutations at numerous non-immunoglobulin gene sequences.

203 ytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usua

204 mode of action is probably a combination of immunoglobulin gene specific activation of AID and a per

205 ne deaminase (AID), that is required for all immunoglobulin gene-specific modification reactions (som

206 HIV have aberrant and unstable expression of immunoglobulin genes suggestive of a high degree humoral

207 ecule-1 (PECAM-1) is a 130-kDa member of the immunoglobulin gene superfamily (IgSF) that is present o

208 nt of mouse 5A11/Basigin, is a member of the immunoglobulin gene superfamily and has been named 5A11/

209 ciated glycoprotein (MAG) is a member of the immunoglobulin gene superfamily and is thought to play a

210 1 (PECAM-1, CD31) is a 130-kDa member of the immunoglobulin gene superfamily expressed on endothelial

211 ial cell adhesion molecule-1 (PECAM-1) is an immunoglobulin gene superfamily member expressed constit

212 at mediate compaction: protein zero (P0), an immunoglobulin gene superfamily member, or proteolipid p

213 Structurally, KIM-1 is a member of the immunoglobulin gene superfamily most reminiscent of muco

214 -1 (PECAM-1, CD31) is a 130-kd member of the immunoglobulin gene superfamily that is expressed on the

215 olecule-1 (PECAM-1) is 130-kDa member of the immunoglobulin gene superfamily that localizes to cell-c

216 Myelin protein zero (MPZ) is a member of the immunoglobulin gene superfamily with single extracellula

217 of huMUC18, a cell adhesion molecule in the immunoglobulin gene superfamily, causes a non-metastatic

218 a cell adhesion/recognition molecule of the immunoglobulin gene superfamily, regulates axon growth a

219 n kinase (MLCK) gene, a muscle member of the immunoglobulin gene superfamily, yields both smooth musc

220 B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily.

221 at, and murine genes that are members of the immunoglobulin gene superfamily.

222 haring sequence homology with members of the immunoglobulin gene superfamily.

223 noma-associated antigen pE4, a member of the immunoglobulin gene superfamily.

224 s encoding antigen receptors on lymphocytes (immunoglobulin genes, T cell receptor genes and NK recep

225 Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the

226 Immunoglobulin genes then experience further diversifica

227 otic gene BCL2 to the regulatory elements of immunoglobulin genes, thereby disrupting 1 heavy-chain a

228 duced deaminase (AID) initiates diversity of immunoglobulin genes through deamination of cytosine to

229 ID) is a B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombinat

230 Because of the extreme diversity in immunoglobulin genes, tolerance mechanisms are necessary

231 iption factor that activates B-cell-specific immunoglobulin gene transcription and is required for ea

232 Immunoglobulin gene transcription was enhanced when Brig

233 ncing the generation of genetic lesions (c- :immunoglobulin gene translocation, -6 overexpression) as

234 l of human Burkitt's lymphoma that bears MYC/Immunoglobulin gene translocations.

235 e (AID) deaminates deoxycytidine residues in immunoglobulin genes, triggering antibody diversificatio

236 During somatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-i

237 sporadic B-CLL display a similar pattern of immunoglobulin gene usage and frequency of somatic mutat

238 ith no apparent tendency for conservation of immunoglobulin gene usage between individuals.

239 s unique and demonstrated a clonal bias; the immunoglobulin gene usage was considerably different fro

240 s exhibited close similarities in phenotype, immunoglobulin gene usage, and mutation status, and expr

241 velopment, low B- and T-cell numbers, normal immunoglobulin gene use, limited B- and T-cell repertoir

242 tic similarity between the human and macaque immunoglobulin genes used to encode some V3-directed MAb

243 (RT-PCR) amplified variable regions of mouse immunoglobulin genes using a strong anion exchange (AEX)

244 in the context of developmentally regulated immunoglobulin gene V(D)J recombination, somatic hypermu

245 tation, switch recombination, and reactivate immunoglobulin gene V(D)J recombination.

246 lineage-specific gene expression program and immunoglobulin gene V(H) to DJ(H) recombination.

247 Immunoglobulin gene variable domains encoding the antibo

248 rom nonautoreactive B cells that diversified immunoglobulin genes via SHM.

249 fied, indicating that machinery to rearrange immunoglobulin genes was intact.

250 PCR for immunoglobulin genes was polyclonal in reactive lymphoid

251 lonality by PCR of T-cell receptor gamma and immunoglobulin genes were categorized in 122 EBV(+) lesi

252 Mice transgenic for human immunoglobulin genes were immunized with OspA from B. bu

253 Transgenic mice with human immunoglobulin genes were immunized with the recombinant

254 Transgenic mice carrying human immunoglobulin genes were used to isolate HuMAbs that ne

255 echnique to amplify clonospecific rearranged immunoglobulin genes, which have applications as markers

256 ned by assembly and sequential expression of immunoglobulin genes, which in turn are regulated by the

257 s commonly bear chromosome translocations to immunoglobulin genes, which points to a role for antibod