ライフサイエンスコーパス: immunoglobulin heavy chain

1 y the loss of individual contacts across the immunoglobulin heavy chain.

2 re-B cells that have successfully rearranged immunoglobulin heavy chain.

3 omain of gp130 fused to the Fc region of the immunoglobulin heavy chain.

4 s with completed V(D)J rearrangements of the immunoglobulin heavy chain.

5 ciated with unassembled, incompletely folded immunoglobulin heavy chains.

6 e sequenced gene rearrangements encoding the immunoglobulin heavy chain, a major determinant of epito

7 a (CLL) samples that expressed more than one immunoglobulin heavy-chain allele and five samples that

8 er they did or did not express more than one immunoglobulin heavy-chain allele.

9 ection of class switch recombination in both immunoglobulin-heavy chain alleles in single cells from

10 pro-B- to pre-B-cell transition and impairs immunoglobulin heavy chain allelic exclusion, hallmarks

11 iants were not restricted to samples lacking immunoglobulin heavy-chain allelic exclusion and most li

12 V-DJ recombination in a transgenic model of immunoglobulin heavy-chain allelic exclusion.

13 hain allele and five samples that had normal immunoglobulin heavy-chain allelic exclusion.

14 highest levels detected in plants expressing immunoglobulin heavy chain alone.

15 pt were found in those plants that expressed immunoglobulin heavy chain alone.

16 DnaJ family member that binds to unassembled immunoglobulin heavy chains along with the BiP chaperone

17 s of the VRC01-class derive from the IGHV1-2 immunoglobulin heavy chain and neutralize a wide spectru

18 To determine the localization of immunoglobulin heavy chains and complement activation in

19 and the lysis of B cells in preparation for immunoglobulin heavy-chain and light-chain amplification

20 ination (CSR) and accumulation of unresolved immunoglobulin heavy chain-associated DSBs.

21 Immunoglobulin heavy chain binding protein (BiP) and two

22 inding protein homologous protein (chop) and immunoglobulin heavy chain binding protein (bip) levels.

23 ly up-regulated (4-8-fold) the expression of immunoglobulin heavy chain binding protein (Bip), calpac

24 te binding protein with sequence identity to immunoglobulin heavy chain binding protein (BiP).

25 Whereas immunoglobulin heavy chain binding protein mRNA was sign

26 of C/EBP homologous protein-10, CHOP-10, and immunoglobulin heavy chain binding protein, BiP, implica

27 induce expression of the molecular chaperone immunoglobulin heavy chain binding protein.

28 Here, we show that loss of the BiP (immunoglobulin heavy-chain binding protein) co-chaperone

29 BiP (immunoglobulin heavy-chain binding protein) is the endop

30 bAB favors cleavage of the newly synthesized immunoglobulin heavy chain-binding protein (BiP) to yiel

31 d, as was the endoplasmic reticulum protein, immunoglobulin heavy chain-binding protein, that co-immu

32 ed expression of UPR target genes, including immunoglobulin heavy chain-binding protein/glucose-regul

33 nd identified ER lumenal molecular chaperone immunoglobulin heavy-chain-binding protein (BiP) as limi

34 complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3), the center of the c

35 Immunoglobulin heavy chain class switch recombination (C

36 Immunoglobulin heavy chain class switch recombination (C

37 king GQN1 a strong candidate for function in immunoglobulin heavy chain class switch recombination.

38 regulate the Iepsilon promoter that controls immunoglobulin heavy chain class switching to IgE.

39 mature B cells are moderately defective for immunoglobulin heavy-chain class switch recombination.

40 ps in vitro, a potential intermediate during immunoglobulin heavy-chain class switch recombination.

41 e activation-induced deaminase (AID) acts at immunoglobulin heavy-chain class switch regions during m

42 The only immunoglobulin heavy-chain classes known so far in teleo

43 cogenic chromosomal abnormalities as well as immunoglobulin heavy chain complementarity region 3 area

44 and exon skipping with the gene encoding the immunoglobulin heavy-chain complex (Igh) and reporter co

45 DNA recombination reaction that replaces one immunoglobulin heavy-chain constant region (Ch) gene wit

46 These include polymorphic genes encoding immunoglobulin heavy chains (defined by serologic marker

47 re of signals that govern the development of immunoglobulin heavy chain-dependent B cells is largely

48 sed CSR and substantial levels of IgH locus (immunoglobulin heavy chain, encoded by Igh) chromosomal

49 ement of genomic DNA that occurs to form the immunoglobulin heavy-chain-encoding sequence in developi

50 ession in B lymphocytes by incorporating the immunoglobulin heavy chain enhancer (E micro ) with and

51 SREBP-1, the transcription factor binding to immunoglobulin heavy chain enhancer 3', and the aryl hyd

52 ell survival to regions juxtaposed to active immunoglobulin heavy chain enhancer elements, chromosoma

53 appaB and Sp1 transcription factors with the immunoglobulin heavy chain enhancer region are important

54 ich CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associa

55 The immunoglobulin heavy chain enhancer, or mu enhancer, is

56 placing an oncogene under the control of the immunoglobulin heavy chain enhancer.

57 ed by means of next-generation sequencing of immunoglobulin heavy chains from circulating memory B ce

58 Chromosomal rearrangements involving the immunoglobulin heavy chain gene (IGH) at 14q32 are obser

59 that establishes the structure of the 2.8-Mb immunoglobulin heavy chain gene (IgH) locus in pro-B cel

60 B cell development and rearrangement of the immunoglobulin heavy chain gene (Igh).

61 0 years, and in prognostic groups defined by immunoglobulin heavy chain gene (V(H)) mutation status a

62 efect in the VH to DJH rearrangement step of immunoglobulin heavy chain gene assembly even though the

63 interaction of these factors with the human immunoglobulin heavy chain gene enhancer regions in t(14

64 In a cell-free system based on the immunoglobulin heavy chain gene enhancer, we show that T

65 required for the complete activation by the immunoglobulin heavy chain gene enhancer.

66 activation of c-myc promoter activity by the immunoglobulin heavy chain gene enhancer.

67 n a loss of promoter activity induced by the immunoglobulin heavy chain gene enhancer.

68 within the bcl-2 5' flanking region and the immunoglobulin heavy chain gene enhancers.

69 2: 18 of 29 (62%) had a translocation of the immunoglobulin heavy chain gene IGH@ on 14q32 to CRLF2 i

70 rimers to amplify the CDR3 VDJ region of the immunoglobulin heavy chain gene in combination with an i

71 factor PU.1 is an important regulator of the immunoglobulin heavy chain gene intronic enhancer, or mu

72 Regulation of the immunoglobulin heavy chain gene is controlled in part by

73 Translocation of the bcl-2 gene to the immunoglobulin heavy chain gene is the most common alter

74 It positively induces gene rearrangements at immunoglobulin heavy chain gene loci by transcriptionall

75 HS) 1, 2, 3, and 4) located 3' of the murine immunoglobulin heavy chain gene play a role in activatin

76 t role in the lineage-specific regulation of immunoglobulin heavy chain gene rearrangement.

77 ndergo clonal expansion following successful immunoglobulin heavy chain gene rearrangement.

78 was used to confirm amplification of clonal immunoglobulin heavy chain gene rearrangements and to es

79 Clonal immunoglobulin heavy chain gene rearrangements were demo

80 on initiation factor-I (TFII-I), to activate immunoglobulin heavy chain gene transcription in the nuc

81 gene driven by the powerful enhancer of the immunoglobulin heavy chain gene, leading to uncontrolled

82 onal machinery to the variable region of the immunoglobulin heavy chain gene.

83 shown to be important for expression of the immunoglobulin heavy chain gene.

84 nd the mechanisms underlying the role of the immunoglobulin heavy-chain gene (IgH) 3' enhancers on bc

85 visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B ce

86 neration sequencing approach to characterize immunoglobulin heavy-chain gene (IGH) repertoires in pat

87 14;18) lymphomas, bcl-2 is juxtaposed to the immunoglobulin heavy-chain gene (IgH), resulting in incr

88 within the bcl-2 5' flanking region and the immunoglobulin heavy-chain gene enhancers.

89 tic factors such as interphase cytogenetics, immunoglobulin heavy-chain gene mutational analysis, and

90 rs (interphase cytogenetics) but not others (immunoglobulin heavy-chain gene mutational status, zeta-

91 D45, CD19, CD5, CD10, kappa, and lambda) and immunoglobulin heavy-chain gene rearrangement by reverse

92 angement occurred in the absence of complete immunoglobulin heavy-chain gene rearrangement.

93 ion on a polymerase chain reaction (PCR) for immunoglobulin heavy-chain gene rearrangements in the fi

94 Southern blot hybridization showed immunoglobulin heavy-chain gene rearrangements in the tu

95 rk that regulates B cell fate commitment and immunoglobulin heavy-chain gene recombination.

96 and relevant secondary surrogate markers of immunoglobulin heavy-chain gene, including methylation o

97 Recent work studying immunoglobulin-heavy chain gene rearrangement postulates

98 Sequence analysis of the immunoglobulin heavy chain genes (IgH) has demonstrated

99 region-binding transcriptional regulator of immunoglobulin heavy chain genes and of E2F1-dependent c

100 ed as at least 1 of the following: unmutated immunoglobulin heavy chain genes, deletion 17p or 11q, o

101 M variable genes are most similar to that of immunoglobulin heavy chain genes.

102 ve variant of CLL characterized by unmutated immunoglobulin heavy-chain genes and with a single nucle

103 ses the interaction of p/CIP with the murine immunoglobulin heavy chain germ line epsilon promoter in

104 at in all donors a heavily biased use of two immunoglobulin heavy chain germlines generated high affi

105 amorphous deposits of a truncated monoclonal immunoglobulin heavy chain (HC) bearing a deletion of th

106 rd complementarity determining region of the immunoglobulin heavy chain (HCDR3).

107 The immunoglobulin heavy chain (IgH) 3' regulatory region mo

108 ulated contraction of the locus encoding the immunoglobulin heavy chain (Igh) and controlled expressi

109 g (V(D)J) recombination at loci encoding the immunoglobulin heavy chain (Igh) and immunoglobulin ligh

110 ng the 3' enhancers of the loci encoding the immunoglobulin heavy chain (Igh) and kappa-light chain (

111 ceptor spectratyping, and deep sequencing of immunoglobulin heavy chain (IGH) and T-cell receptor del

112 Immunoglobulin heavy chain (IgH) class switch recombinat

113 tes DNA double-strand break (DSB) repair and immunoglobulin heavy chain (IgH) class switch recombinat

114 Immunoglobulin heavy chain (IgH) class switch recombinat

115 Immunoglobulin heavy chain (IgH) class-switch recombinat

116 ks (DSBs) into switch (S) regions that flank immunoglobulin heavy chain (IgH) constant region exons.

117 ty of 0.8 and sensitivity of 0.65 to 0.95 by immunoglobulin heavy chain (IGH) gene arrangement testin

118 comprehensive view of DNA methylation at the immunoglobulin heavy chain (IgH) gene locus prior to and

119 The immunoglobulin heavy chain (IgH) gene locus spans severa

120 lated recombination and transcription of the immunoglobulin heavy chain (IgH) gene locus.

121 A clonal rearrangement of the immunoglobulin heavy chain (IgH) gene was identified in

122 Immunoglobulin heavy chain (IgH) genes are formed, teste

123 monstrated in knock-in mouse models carrying immunoglobulin heavy chain (IgH) genes encoding self-rea

124 In particular, the rearrangement of immunoglobulin heavy chain (IgH) genes in murine PDCs an

125 B cell-specific expression of immunoglobulin heavy chain (IgH) genes utilizes two cis

126 merase chain reaction (PCR) amplification of immunoglobulin heavy chain (IgH) genes.

127 which we determined the progenitor B cell by immunoglobulin heavy chain (IgH) genotyping.

128 hieved on tissue-specific genes, such as the immunoglobulin heavy chain (IgH) in B cells remains uncl

129 romatin remodeling constraints as endogenous immunoglobulin heavy chain (IgH) loci and examined the r

130 terized by complicon formation involving the immunoglobulin heavy chain (Igh) locus and the c-myc onc

131 determine the exact breakpoints in both the immunoglobulin heavy chain (IGH) locus and the partner c

132 dentify a novel susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a hap

133 e 3' regulatory region (3' RR) of the murine immunoglobulin heavy chain (IgH) locus contains multiple

134 Chromosomal translocations involving the immunoglobulin heavy chain (IGH) locus define common sub

135 V(D)J recombination at the immunoglobulin heavy chain (IgH) locus follows the 12/23

136 ncoded by a gene found to translocate to the immunoglobulin heavy chain (IgH) locus in some mucosa-as

137 VDJ rearrangement in the mouse immunoglobulin heavy chain (Igh) locus involves a combin

138 ns based on the sequence of their rearranged immunoglobulin heavy chain (IgH) locus is an important t

139 The intronic enhancer (E mu) of the immunoglobulin heavy chain (IgH) locus is critical for V

140 double-strand breaks (DSBs) within two large immunoglobulin heavy chain (IgH) locus switch (S) region

141 Transcription at the immunoglobulin heavy chain (Igh) locus targets CSR-assoc

142 We identify the immunoglobulin heavy chain (IGH) locus to be associated

143 We identified a TTR in the mouse immunoglobulin heavy chain (Igh) locus, which contains r

144 d by chromosome translocations involving the immunoglobulin heavy chain (IgH) locus.

145 ype switching to IgE in human subjects using immunoglobulin heavy chain (IGH) mutational lineage data

146 Production of immunoglobulin heavy chain (IgH) protein feeds back to t

147 The production of immunoglobulin heavy chain (IgH) protein in pro-B cells

148 We studied the molecular features of the immunoglobulin heavy chain (IGH) rearrangements in 165 p

149 In plasma cells, immunoglobulin heavy chain (IgH) secretory-specific mRNA

150 nslocations, which are mediated by errors in immunoglobulin heavy chain (IgH) switch recombination or

151 Chromosomal translocations involving immunoglobulin heavy chain (Igh) switch regions and an o

152 as and frequently have chromosomal breaks in immunoglobulin heavy chain (IgH) switch regions, suggest

153 uid specimens and more recently by molecular-immunoglobulin heavy chain (IGH) translocation or cytoki

154 The characterization of immunoglobulin heavy chain (IGH) translocations provides

155 severely defective for recombination of all immunoglobulin heavy chain (IgH) V gene segments, but th

156 B-cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segmen

157 in most cases and typically carry rearranged immunoglobulin heavy chain (IGH) variable (V) region gen

158 Immunoglobulin heavy chain (IgH) variable region exons a

159 pre- and post-HCT relapse risk, we performed immunoglobulin heavy chain (IgH) variable, diversity, an

160 and survival impact of del(6)(q22) and BCL6, immunoglobulin heavy chain (IGH), and MYC gene rearrange

161 Of 51 MBL samples in which immunoglobulin heavy chain (IGH)V-D-J genotypes could be

162 Genes encoding immunoglobulin heavy chains (Igh) are assembled by rearr

163 The immunoglobulin heavy-chain (IgH) gene locus undergoes ra

164 The first steps of murine immunoglobulin heavy-chain (IgH) gene recombination take

165 - and growth factor-induced up-regulation of immunoglobulin heavy-chain (IgH) genes and in E2F1-depen

166 sed a defect in somatic rearrangement in the immunoglobulin heavy-chain (IgH) locus and a block in th

167 FISH-based techniques, rearrangements of the immunoglobulin heavy-chain (IgH) locus at 14q32 have bee

168 Large-scale contraction of the immunoglobulin heavy-chain (Igh) locus facilitates rearr

169 The immunoglobulin heavy-chain (Igh) locus is organized into

170 The murine immunoglobulin heavy-chain (Igh) locus provides an impor

171 The immunoglobulin heavy-chain (IgH) locus undergoes large-s

172 Translocations at the immunoglobulin heavy-chain (IgH) locus, 14q32, are likel

173 itiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, leading to defec

174 Tumor-related immunoglobulin heavy-chain (IgH) rearrangements are mark

175 Immunoglobulin heavy-chain (IgH) translocations are seen

176 All identified SNPs are clustered around the immunoglobulin heavy chain (IGHC) locus on chromosome 14

177 The pre-BCR constitutes an immunoglobulin heavy chain (Igmu) and a surrogate light

178 )-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific

179 tes to transcriptional activation by the Emu immunoglobulin heavy chain intron enhancer by binding to

180 ion strongly reduces the ability of a distal immunoglobulin heavy chain intronic enhancer to stimulat

181 lear matrix attachment regions (MARs) of the immunoglobulin heavy chain intronic enhancer.

182 (HCs) is the frequent expression of multiple immunoglobulin heavy chain isotypes, with dominance of i

183 rs, interleukin-10, chemokine receptors, and immunoglobulin heavy-chain isotypes, was measured.

184 ulin heavy chain gene in combination with an immunoglobulin heavy chain joining region consensus prim

185 obulin heavy chain transcription) binding to immunoglobulin heavy chain loci after B-cell activation

186 boundaries of R-loops are well-documented at immunoglobulin heavy chain loci in mammalian B cells.

187 include, among others, translocations of the immunoglobulin heavy chain locus (IgH).

188 d by the spatio-temporal organization of the immunoglobulin heavy chain locus (Igh).

189 t link c-myc or other proto-oncogenes to the immunoglobulin heavy chain locus (IgH, encoded by Igh).

190 Translocations into the immunoglobulin heavy chain locus and aneuploidy are near

191 and antisense strand DNA mutagenesis at the immunoglobulin heavy chain locus and some other regions

192 The human immunoglobulin heavy chain locus contains 39 functional

193 presence of one of the translocations in the immunoglobulin heavy chain locus influenced the expressi

194 cular lymphoma, bcl-2 is translocated to the immunoglobulin heavy chain locus leading to deregulation

195 In this report, we have used the immunoglobulin heavy chain locus to address the role of

196 The previously reported association of the immunoglobulin heavy chain locus with immunoglobulin G i

197 initiated by deamination of C-->U within the immunoglobulin heavy chain locus, catalyzed by activatio

198 erted into its physiological position in the immunoglobulin heavy chain locus.

199 c, occurs extensively in the V region of the immunoglobulin heavy chain locus.

200 d acquired a translocation of c-myc into the immunoglobulin heavy chain locus.

201 t derived from the large VH-CH intron of the immunoglobulin heavy chain locus.

202 lities and recurrent translocations into the immunoglobulin heavy chain locus.

203 pairs at the region downstream of JH4 in the immunoglobulin heavy chain locus.

204 enic translocations juxtaposes c-myc and the immunoglobulin heavy-chain locus (IgH) and is found in B

205 ently generated at switch (S) regions in the immunoglobulin heavy-chain locus (Igh), consistent with

206 00 kb apart within switch (S) regions in the immunoglobulin heavy-chain locus (IgH).

207 The profiling of S(mu) and immunoglobulin heavy-chain locus (IgH-VH) mutations in f

208 ves the rearrangement of germline DNA in the immunoglobulin heavy-chain locus and is stimulated by cy

209 The break at the immunoglobulin heavy-chain locus on chromosome 14 is an

210 Productive rearrangement of the immunoglobulin heavy-chain locus triggers a major develo

211 Immunoglobulin heavy-chain locus V(D)J recombination req

212 ble, diversity, joining rearrangement at the immunoglobulin heavy-chain locus, a permanent genetic ch

213 cDNA, Myc(His), head to head into the mouse immunoglobulin heavy-chain locus, Igh, just 5' of the in

214 ad to head into different sites of the mouse immunoglobulin heavy-chain locus, Igh, mimic the chromos

215 variable gene segments and compaction of the immunoglobulin heavy-chain locus.

216 d to recombine variable gene segments at the immunoglobulin heavy-chain locus.

217 e nuclear repositioning or compaction of the immunoglobulin heavy-chain locus.

218 s revealed that translocations involving the immunoglobulin-heavy chain locus occurred exclusively in

219 induce a DNase I-hypersensitive site at the immunoglobulin heavy chain micro enhancer in vitro.

220 wer abundance of secretory-specific forms of immunoglobulin heavy-chain mRNA.

221 (A) site and was necessary for processing of immunoglobulin heavy-chain mRNA.

222 Furthermore, immunoglobulin heavy chain ongoing mutation status, whic

223 by the presence of clonal rearrangements of immunoglobulin heavy chain or T-cell receptor gamma chai

224 fluorescent protein under the control of an immunoglobulin heavy chain promoter and selected for hig

225 ane protein 1 (LMP1) under the control of an immunoglobulin heavy-chain promoter and enhancer develop

226 nsensus MORE (ATGCATATGCAT) or on MOREs from immunoglobulin heavy chain promoters (AT[G/A][C/A]ATATGC

227 as the heptamer/octamer motif) are found in immunoglobulin heavy chain promoters.

228 Immunoglobulin heavy chain rearrangement (V(H)-to-DJ(H))

229 BLIN-4E and BLIN-4L have the identical immunoglobulin heavy chain rearrangement and a CD10(+)/C

230 rogenase isozyme 5, beta2-microglobulin, and immunoglobulin heavy chain rearrangement studies have im

231 r immunoglobulin lambda chain 5, and contain immunoglobulin heavy-chain rearrangements, suggesting th

232 oth the major histocompatibility complex and immunoglobulin heavy chain region as major determinants.

233 trated both at the cyclin D1 promoter and 3' immunoglobulin heavy-chain regulatory regions only in ma

234 The immunoglobulin heavy chain repertoire is generated by so

235 ss 6.5 years to show that the BM plasma cell immunoglobulin heavy chain repertoire is remarkably stab

236 continues to contract while the diversity of immunoglobulin heavy chain repertoire recovers.

237 sfected with Bright and/or Btk along with an immunoglobulin heavy chain reporter construct.

238 The highly repetitive human immunoglobulin heavy chain sequence was analyzed using w

239 Younger age and mutated immunoglobulin heavy chain status were significant risk

240 fic model system, it was determined that the immunoglobulin heavy chain subunit of the IgM BCR of nor

241 myeloid genes in vitro, including gp91-phox, immunoglobulin heavy chain, the T-cell receptor beta and

242 n switch from the membrane-bound form of the immunoglobulin heavy chain to its secreted form by activ

243 Bright (B-cell regulator of immunoglobulin heavy chain transcription) binding to imm

244 Bright, for B cell regulator of immunoglobulin heavy chain transcription, binds A+T-rich

245 s been characterized both as an activator of immunoglobulin heavy-chain transcription and as a proto-

246 apsulated bacteria and molecular analysis of immunoglobulin heavy chain transcripts were studied for

247 m these B cells lack functionally rearranged immunoglobulin heavy-chain transcripts, as shown by PCR-

248 Using immunoglobulin heavy chain transgenic mice, we show that

249 year PFS was 53.9% for patients with mutated immunoglobulin heavy chain variable (IGHV) gene (IGHV-M)

250 sex, Rai stage, CD38 status, ZAP-70 status, immunoglobulin heavy chain variable (IGHV) gene mutation

251 in of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each h

252 nd that these changes are more pronounced in immunoglobulin heavy chain variable (IGHV)-unmutated CLL

253 phenotypic features of 13 cases of I-SLL and immunoglobulin heavy chain variable (VH) gene sequences

254 Multivariate modeling revealed immunoglobulin heavy chain variable gene (IGHV) mutation

255 This effect was independent of treatment, immunoglobulin heavy chain variable gene (IGHV) status,

256 be predicted by analysis of mutations in the immunoglobulin heavy chain variable gene (IGHV).

257 A mutated immunoglobulin heavy chain variable gene and trisomy 12

258 s had high-risk features: 94% with unmutated immunoglobulin heavy chain variable gene rearrangement,

259 ulation of poor prognostic markers-unmutated immunoglobulin heavy chain variable genes, ZAP-70/CD38 p

260 ressing unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain variable genes.

261 ct relative to CD38 and ZAP-70 expression or immunoglobulin heavy chain variable region (IGHV) status

262 Such enhanced expression was more evident in immunoglobulin heavy chain variable region (IGHV)-mutate

263 < .001), and the absence of mutation in the immunoglobulin heavy chain variable region (IgV(H)) (P <

264 repertoires by several mechanisms, including immunoglobulin heavy chain variable region (V(H)) replac

265 by the identification of a single rearranged immunoglobulin heavy chain variable region (VH) sequence

266 carrying CHD2 mutations also present mutated immunoglobulin heavy chain variable region genes (IGHVs)

267 ell expression of ZAP-70, CD38, or unmutated immunoglobulin heavy chain variable region genes (U-IGHV

268 revealed that CL1/CL2 combination score and immunoglobulin heavy chain variable region mutation stat

269 tment, whereas CL1/CL3 combination score and immunoglobulin heavy chain variable region mutation stat

270 induction of Noxa and Puma, independently of immunoglobulin heavy chain variable region mutational st

271 ltivariable models of PFS and OS showed that immunoglobulin heavy chain variable region mutational st

272 Next-generation sequencing of an immunoglobulin heavy chain variable region repertoire be

273 The tumor immunoglobulin heavy chain variable region was more freq

274 onic lymphocytic leukemia (CLL), analysis of immunoglobulin heavy chain variable regions for somatic

275 s also showed activation of their endogenous immunoglobulin heavy chain variable regions.

276 Chromosomal abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene m

277 3 as well as established prognostic markers (immunoglobulin heavy chain variable-region mutation stat

278 undance of RNA polymerase II (Pol II) at the immunoglobulin heavy-chain variable (Igh-V) region compa

279 Of the immunoglobulin heavy-chain variable (IGHV) genes express

280 The presence of immunoglobulin heavy-chain variable (IGHV) genes was det

281 In chronic lymphocytic leukemia (CLL), the immunoglobulin heavy-chain variable (IgVH) region may be

282 Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments

283 ter memory B cells that usually have mutated immunoglobulin heavy-chain variable (VH) genes.

284 During B lymphocyte development, immunoglobulin heavy-chain variable (VH), diversity (DH)

285 some 17p13.1 deletion, and 75% had unmutated immunoglobulin heavy-chain variable genes.

286 , and IgM CD19-positive B cells expressing 6 immunoglobulin heavy-chain variable region (VH) subgroup

287 ecting TP53 and the mutational status of the immunoglobulin heavy-chain variable region are important

288 s systematic review, we examined the role of immunoglobulin heavy-chain variable region gene (IGHV) m

289 Use of immunoglobulin heavy-chain variable region gene families

290 positive results (P = .0002) and had mutated immunoglobulin heavy-chain variable region gene status (

291 e high Rai risk, 71% were nonmutated for the immunoglobulin heavy-chain variable region gene, 34% wer

292 eukemia (CLL) B cells that express unmutated immunoglobulin heavy-chain variable region genes (IgV(H)

293 espect to the somatic mutation status of the immunoglobulin heavy-chain variable region genes.

294 70), the mutational status of the rearranged immunoglobulin heavy-chain variable-region (IgV(H) ) gen

295 time to first treatment irrespective of the immunoglobulin heavy-chain variable-region gene (IGHV) m

296 , the CLL cells usually express an unmutated immunoglobulin heavy-chain variable-region gene (IgV(H))

297 , we performed high-throughput sequencing of immunoglobulin heavy chain VDJ rearrangements of naive,

298 stinct RNA transcriptome signature and human immunoglobulin heavy chain (VH) repertoire that was rela

299 whose population is dramatically expanded in immunoglobulin heavy chain Vh11 knock-in mice.

300 hains only, without expression of the normal immunoglobulin heavy chain, which constitutes light-chai