ライフサイエンスコーパス: immunoglobulin variable region

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1 osome core histones, ribonucleoproteins, and immunoglobulin variable regions.

2 ship in either the heavy- or the light-chain immunoglobulin variable regions.

3 We describe a single immunoglobulin variable region domain that specifically

4 cells, acquire N-glycosylation sites in the immunoglobulin variable regions during somatic hypermuta

5 erases introduce nucleotide substitutions in immunoglobulin variable regions during somatic hypermuta

6 Immunoglobulin variable region exons are assembled in de

7 However, although transcription through immunoglobulin variable region exons is required for SHM

8 at HCV-associated lymphomas use a restricted immunoglobulin variable region gene repertoire.

9 It is believed that immunoglobulin-variable region gene (IgV) somatic hyperm

10 CLL B cells that have nonmutated immunoglobulin variable region genes (V genes) expressed

11 Analysis of immunoglobulin variable region genes has revealed somati

12 Targeted hypermutation of immunoglobulin variable region genes occurs in B cells d

13 ntroduction of many point mutations into the immunoglobulin variable region genes.

14 Genomic features including unmutated immunoglobulin variable region heavy chain (IgVH) genes,

15 were Rai stage of 1 or higher and unmutated immunoglobulin variable region heavy chain (IgVH).

16 ed to the discovery of new prognostic tools (immunoglobulin variable-region heavy chain gene mutation

17 ts from human blood and spleen revealed that immunoglobulin variable region (IgV) gene unmutated CLL

18 Immunoglobulin variable region (IgV) genes are diversifi

19 ic hypermutation (SHM) targets primarily the immunoglobulin variable region (IgV) genes in germinal c

20 shown that >50% of CLLs display hypermutated immunoglobulin variable region (IgV) sequences and a mor

21 Partitioning the human immunoglobulin variable region into variable (V), divers

22 Targeted diversification of immunoglobulin variable regions is induced by activation

23 We used the immunoglobulin variable regions isolated from sorted sin

24 todomains at 2.4 A resolution reveals paired immunoglobulin variable region-like domains with a strik

25 chimeric antigen receptors (CARs) encompass immunoglobulin variable regions or receptor ligands as t

26 The restriction of immunoglobulin variable region promoter activity to B ly

27 Immunoglobulin variable region promoters are predominant

28 Somatic mutations within the immunoglobulin variable region were almost exclusively p

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