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3 ne protein and member of a family of related immunoglobulin-like adhesion molecules, as a potential t
4 Here we genetically targeted a stretch of 14 immunoglobulin-like and fibronectin type 3 domains that
6 a string of globular domains including eight immunoglobulin-like and three fibronectin-like domains t
13 The mu3A C-terminal domain consists of an immunoglobulin-like beta-sandwich organized into two sub
14 tations, we have solved the structure of the immunoglobulin-like C1 domain of MyBP-C by X-ray crystal
15 '-D''-alpha1-alpha2 subdomain grafted on the immunoglobulin-like core of FaeG hosts the carbohydrate
18 sialylation of the N-glycans on the adjacent immunoglobulin-like domain (Ig5), and acidic residues on
20 LT-1 extracellular domain, suggest that this immunoglobulin-like domain autonomously plays an as yet
22 ular fragment of TLT-1 consists of a single, immunoglobulin-like domain connected to the platelet cel
23 lipoprotein remnant receptor family known as immunoglobulin-like domain containing receptor 1 (ILDR1)
24 ILDR1 encodes the evolutionarily conserved immunoglobulin-like domain containing receptor 1, a puta
26 hicken CAR, or with the heterologous type C2 immunoglobulin-like domain from IgSF11, another IgSF mem
27 engage a conserved hydrophobic groove in the immunoglobulin-like domain III (D3) of the "c" splice is
29 d by six leucine-rich repeat domains and one immunoglobulin-like domain in their extracellular moieti
33 affecting a conserved residue in the second immunoglobulin-like domain of titin, was introduced in a
39 g site on the apical surface between the two immunoglobulin-like domains (D1D2) of the receptor and s
40 nal actin-binding domain and 24 filamin-type immunoglobulin-like domains (FLN) that form tail-to-tail
41 ure of the agrin-responsive first and second immunoglobulin-like domains (Ig1 and Ig2) of the MuSK ec
43 Here, we found that leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is highly expresse
44 receptor antagonist leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1), for further study
45 in LRIG2, encoding leucine-rich repeats and immunoglobulin-like domains 2, a protein implicated in n
48 t has not been reported in tandem repeats of immunoglobulin-like domains and that is presumably conse
49 riant of human peroxidasin 1 comprising four immunoglobulin-like domains and the catalytically active
50 All methods indicate that the extracellular immunoglobulin-like domains are monomeric in solution an
51 ke related immune receptors, GPVI contains 2 immunoglobulin-like domains arranged in a perpendicular
52 mbrane glycoprotein, with four extracellular immunoglobulin-like domains containing three intrachain
53 in malignant transformation, we removed two immunoglobulin-like domains from the extracellular domai
56 indicate that 1C3 inhibits clustering of the immunoglobulin-like domains of GPVI on collagen/CRPs, a
58 e crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa r
61 e complex shows how AlkC uses unique HLR and immunoglobulin-like domains to induce a sharp kink in th
63 The extracellular domain of Tvc contains two immunoglobulin-like domains, IgV and IgC, which presumab
64 , both elastin and HTE bind to the same LigB immunoglobulin-like domains, including LigBCon4, LigBCen
65 arge modular protein composed mainly of many immunoglobulin-like domains, is a potent cross-linker of
66 spite previous assignment to the C2 class of immunoglobulin-like domains, the structure of IgD1 revea
68 , heparanase 2, and leucine-rich repeats and immunoglobulin-like domains-2 (LRIG2), which is mutated
72 n, the crystal structure of the CD8alphabeta immunoglobulin-like ectodomains were determined in compl
73 transmembrane protein, is composed of three immunoglobulin-like extracellular loops as well as a cyt
74 ment of FLNa containing Ig repeat 10 or with immunoglobulin-like filamin A repeat (IgFLNa)10 alone.
75 6IIe mutation maps within a highly conserved immunoglobulin-like fold (Ig10 domain) located in the sp
76 gy, consisting of two domains: an incomplete immunoglobulin-like fold (pilin body) and an N-terminal
77 N domain resolved to 2.0 A reveals a variant immunoglobulin-like fold and potential heparin-binding s
78 antigenic motifs in a single-domain chimeric immunoglobulin-like fold generated a vaccine that greatl
79 na by NMR and shown that it adopts a type of immunoglobulin-like fold not previously reported in lowe
80 ZP-N region, the ZP-C region also adopts an immunoglobulin-like fold, despite sharing no sequence ho
84 and carboxy-terminal domains of E2 each form immunoglobulin-like folds, consistent with the receptor
85 HSP27 and alphaB-crystallin associated with immunoglobulin-like (Ig) domain-containing regions, but
86 ers, is built from approximately 300 regular immunoglobulin-like (Ig) domains and FN-III repeats.
88 e ectodomain of neogenin is composed of four immunoglobulin-like (Ig) domains followed by six fibrone
89 Kettin is a large actin-binding protein with immunoglobulin-like (Ig) repeats, which is associated wi
90 elasticity; secondary structures of titin's immunoglobulin-like (Ig-) and fibronectin type III-like
92 terminal actin-binding domain followed by 24 immunoglobulin-like (IgFLN) domains and we find that mig
93 transmission, are derived from extracellular immunoglobulin-like (IgL) domains and cytoplasmic immuno
95 ) disease, and more recently the killer cell immunoglobulin-like (KIR) locus has been implicated in d
96 for NK cell inhibition via inhibitory killer immunoglobulin-like (KIR) receptors and interrupts their
97 (Sn, Siglec-1, CD169), a sialic acid-binding immunoglobulin-like lectin (Siglec) expressed on subsets
99 CD33 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family of inhibitory
102 D22 is a B cell-specific sialic acid-binding immunoglobulin-like lectin (Siglec) whose function as a
106 responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory r
108 l differentiation marker sialic acid-binding immunoglobulin-like lectin F and overproduced TNF and IL
109 crophages (AMs; CD11c(+) sialic acid-binding immunoglobulin-like lectin F(+)) in vivo and likewise de
110 mbrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that regulates innate immunit
112 y on 2 families of GBPs, sialic acid-binding immunoglobulin-like lectins (siglecs) and selectins, tha
114 e CD33-related subset of sialic acid-binding immunoglobulin-like lectins (Siglecs) consists of immuno
115 rom the siglec family of sialic acid-binding immunoglobulin-like lectins, for the glycosaminoglycan-b
116 We report that certain Sialic-acid-binding immunoglobulin-like-lectins (siglecs) are expressed in h
118 lement regulators is mediated by leptospiral immunoglobulin-like (Lig) proteins, previously shown to
120 ation by dimerization of the membrane-distal immunoglobulin-like loop and a C-terminal postsynaptic d
127 ly, we and others have shown that Leptospira immunoglobulin-like proteins (Lig) of Leptospira spp. bi
128 cloning and characterization of leptospiral immunoglobulin-like proteins LigA and LigB of Leptospira
130 , NK cells that express an inhibitory killer immunoglobulin-like receptor (iKIR) for which the respec
132 atural killer (NK) cell receptor, the killer immunoglobulin-like receptor (KIR) 3DS1, and its presume
133 ow that the number of activating killer cell immunoglobulin-like receptor (KIR) copies in rhesus monk
135 tion (PCR) assays to compare NKG2 and killer immunoglobulin-like receptor (KIR) gene expression in NK
137 analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on th
140 played by the inherited repertoire of killer immunoglobulin-like receptor (KIR) genes therefore may i
142 killer (NK) receptors, in particular, killer immunoglobulin-like receptor (KIR) KIR3DL2, a receptor f
144 class I ligands for donor inhibitory killer immunoglobulin-like receptor (KIR) receptors, as predict
146 tural killer (NK) cells that use killer-cell immunoglobulin-like receptor (KIR) to recognize the feta
148 cell alloreactivity mediated by killer cell immunoglobulin-like receptor (KIR)-HLA interactions may
149 ations before 2004, patient C2C2 killer cell immunoglobulin-like receptor (KIR)-ligand phenotype, and
150 explore the association between killer cell immunoglobulin-like receptor (KIR)/HLA and human immunod
153 d myelomonocytic cells, CD94/NKG2, leukocyte immunoglobulin-like receptor (LILR), and killer immunogl
155 B2 (LILRB2) and its mouse orthologue paired immunoglobulin-like receptor (PIRB) are receptors for se
158 or lacking the inhibitory receptor leukocyte immunoglobulin-like receptor 1 (LIR1) were differentiall
159 but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism
161 ogens are specifically detected by leukocyte immunoglobulin-like receptor A2 (LILRA2), an orphan acti
163 ssion of inhibitory receptors such as paired immunoglobulin-like receptor B (PIR-B) and their functio
164 d the role of the inhibitory receptor paired immunoglobulin-like receptor B (PIR-B) in the regulation
165 investigate the potential function of paired immunoglobulin-like receptor B (PIR-B), also known as le
168 xpression cloning, we have found that paired immunoglobulin-like receptor B (PirB), which has been im
171 a subset of RIFINs binds to either leucocyte immunoglobulin-like receptor B1 (LILRB1) or leucocyte-as
172 for trophoblast HLA-G stimulating leukocyte immunoglobulin-like receptor B1 receptors on decidual le
173 e immune-inhibitory receptor human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse o
174 yelomonocytic HLA class I receptor leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4), while bi
175 B) and its human ortholog LilrB2 (leukocyte immunoglobulin-like receptor B2), present in human brain
176 ng positions 9, 99, 116, and 156, and killer immunoglobulin-like receptor binding position 77 of HLA-
178 ents (n=222) and controls (n=191) for killer immunoglobulin-like receptor gene polymorphisms did not
179 important for NK cell function, killer cell immunoglobulin-like receptor inhibitory signaling affect
180 s knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocyte
181 ors for improved outcome were missing killer immunoglobulin-like receptor ligand (PFS and OS), human
182 1/5-positive granulocytes and missing killer immunoglobulin-like receptor ligand as positive independ
183 he model for OS also included missing killer immunoglobulin-like receptor ligand, human antimouse ant
184 ns (Rho-GTPase-activing protein 5, leukocyte immunoglobulin-like receptor subfamily A member 4 precur
185 al regulatory protein) and LILRB1 (leukocyte immunoglobulin-like receptor subfamily B member 1) showi
186 receptor B (PIR-B), also known as leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB
187 9x10(-16); R(2)=0.02) and with the leukocyte immunoglobulin-like receptor subfamily B member 5 (LILRB
188 ucts (RAGE) is an ubiquitous, transmembrane, immunoglobulin-like receptor that exists in multiple iso
189 NK cells predominately expressed killer cell immunoglobulin-like receptor, and self-killer cell immun
190 feron gamma receptor 2 (IFNGR2); killer cell immunoglobulin-like receptor, three domain, long cytopla
192 d on days -6 through -2), followed by killer immunoglobulin-like receptor-human leukocyte antigen (KI
193 lobulin-like receptors, a fraction of killer immunoglobulin-like receptor-positive-expressing cells t
194 netic studies suggest a role for killer cell immunoglobulin-like receptor/HLA (KIR/HLA) compound geno
196 iller (NK) cells and their activating killer immunoglobulin-like receptors (aKIRs) influence the immu
197 omodulatory CD33-related sialic acid-binding immunoglobulin-like receptors (CD33rSiglecs) and maximum
198 tor function depends on specific killer-cell immunoglobulin-like receptors (KIR) and HLA interactions
199 mans, interactions between inhibitory killer immunoglobulin-like receptors (KIR) and human MHC (HLA)
202 -B27 and immune receptors such as the killer immunoglobulin-like receptors (KIR) found on a range of
203 ting and inhibitory forms of the killer cell immunoglobulin-like receptors (KIR) in natural killer (N
205 function can be modulated by the killer cell immunoglobulin-like receptors (KIR) which interact with
206 ally mediated through binding of killer-cell immunoglobulin-like receptors (KIR) with HLA class I lig
207 human leukocyte antigens (HLA), killer-cell immunoglobulin-like receptors (KIR), major histocompatib
208 nate immunity as ligands for the killer cell immunoglobulin-like receptors (KIR), which modulate natu
213 n interaction between inhibitory killer cell immunoglobulin-like receptors (KIRs) and HLA class I lig
215 oreactivity, determined by donor killer-cell immunoglobulin-like receptors (KIRs) and recipient HLA,
216 lex (MHC) class I, including the killer cell immunoglobulin-like receptors (KIRs) and the C-type lect
217 wo such families of NK receptors, the killer immunoglobulin-like receptors (KIRs) and the killer cell
218 Epistatic interactions between killer cell immunoglobulin-like receptors (KIRs) and their cognate H
219 pon diverse interactions between killer cell immunoglobulin-like receptors (KIRs) and their HLA class
221 ls are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interacti
222 lymorphic sets of molecules: the killer-cell immunoglobulin-like receptors (KIRs) and their major his
225 Because the HLA-C locus and killer cell immunoglobulin-like receptors (KIRs) are of key importan
226 ules as ligands to NK cell inhibitory killer immunoglobulin-like receptors (KIRs) as a means of immun
228 attenuated by ligation of inhibitory killer immunoglobulin-like receptors (KIRs) by HLA class I mole
230 e the crucial role of activating killer-cell immunoglobulin-like receptors (KIRs) in NK cell-mediated
231 role of NK cells expressing specific killer immunoglobulin-like receptors (KIRs) in the control of h
234 been attributed to mismatches between killer immunoglobulin-like receptors (KIRs) on NK cells and the
238 ity and reproduction are diverse killer cell immunoglobulin-like receptors (KIRs) that recognize poly
240 asing age, T cells gain expression of killer immunoglobulin-like receptors (KIRs) that transmit negat
243 se receptor families such as the killer cell immunoglobulin-like receptors (KIRs), and (ii) indirect
244 cluding the activating and inhibitory killer immunoglobulin-like receptors (KIRs), and human leukocyt
245 iller (NK) cells possess little or no killer immunoglobulin-like receptors (KIRs), high interferon-ga
247 re a group of genes encoding the killer cell immunoglobulin-like receptors (KIRs), which have known a
249 ession pattern of immunomodulatory leukocyte-immunoglobulin-like receptors (LILR) and a strong and se
251 the activating receptor NKp46 and the killer immunoglobulin-like receptors 2DL1/S1 and 3DL1, reduced
252 he association of natural killer cell killer immunoglobulin-like receptors and human leukocyte antige
253 e frequently expressed educating killer cell immunoglobulin-like receptors compared with NK cells in
254 closely monitored by NK cells, whose killer immunoglobulin-like receptors encode MHC-I-specific acti
256 rus binding to a sialic acid receptor and to immunoglobulin-like receptors used by most other enterov
257 globulin-like receptor, and self-killer cell immunoglobulin-like receptors were required for robust I
258 )M-CSFR(+)) showed more expression of killer immunoglobulin-like receptors, a fraction of killer immu
259 eptors, mannose-binding lectin, CD14, killer immunoglobulin-like receptors, and matrix metalloprotein
260 immune-cell-specific genes, including novel immunoglobulin-like receptors, and neofunctionalization
261 ontains the allelic sequences of killer-cell immunoglobulin-like receptors, IPD-MHC, a database of se
262 ontains the allelic sequences of Killer-cell Immunoglobulin-like Receptors, IPD-MHC, is a database of
263 uch as human leukocyte antigens, killer-cell immunoglobulin-like receptors, major histocompatibility
268 hy, we show how the CFTR N terminus binds to immunoglobulin-like repeat 21 of filamin A (FlnA-Ig21).
270 ntains the partial eleventh and full twelfth immunoglobulin-like repeats (LigBCen2R) and 47 amino aci
271 CFTR N terminus also binds to several other immunoglobulin-like repeats from filamin A in vitro.
272 he Lig surface proteins containing imperfect immunoglobulin-like repeats that are shared or differ be
273 tilization of different surfaces of a single immunoglobulin-like scaffold to generate binding protein
276 the full activation of TAMs and that soluble immunoglobulin-like TAM domains act as specific ligand a
278 ibits substantially increased binding to the immunoglobulin-like transcript (ILT) receptor 4, an inhi
280 Cs) were identified and expressions of CD86, immunoglobulin-like transcript 3 (ILT3) and ILT4 were an
281 regulation of the surface receptor ILT3, the immunoglobulin-like transcript 3 that is normally found
282 ) ) and regulatory dendritic cells (DCregs) (immunoglobulin-like transcript 3(+) /4(+) ); (2) liver b
283 how that primary human neutrophils expressed immunoglobulin-like transcript 4 (ILT4) inhibitory recep
284 lecule B*3503 binds with greater affinity to immunoglobulin-like transcript 4 (ILT4), an inhibitory M
285 Interaction of HLA-G with its receptor, immunoglobulin-like transcript 4 on dendritic cells (DCs
289 sessed expression of PIR-B human homologues (immunoglobulin-like transcript [ILT]-2 and ILT-3) in col
291 imeric structure, partly held together by an immunoglobulin-like trimerization domain that is C-termi
293 eater degree with the gB receptor the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) th
295 herpesvirus entry mediator (HVEM) or paired immunoglobulin-like type 2 receptor alpha (PILRalpha).
297 herpesvirus entry mediator (HVEM), or paired immunoglobulin-like type-2 receptor alpha (PILRalpha).
299 re composed of alphabeta subunits displaying immunoglobulin-like variable domains that recognize pept
300 The structure of TLT-1 is similar to other immunoglobulin-like variable domains, particularly those
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