ライフサイエンスコーパス: immunoglobulin-like domain

1 e in the Trk receptors resides in the second immunoglobulin-like domain.

2 nalogous region of UL18 using its N-terminal immunoglobulin-like domain.

3 l describes the aggregation of Titin I27, an immunoglobulin-like domain.

4 ranslational folding on the ribosome of this immunoglobulin-like domain.

5 to residues 71 to 289, a region including an immunoglobulin-like domain.

6 egulate Trio localization via binding to the immunoglobulin-like domain.

7 beta-propeller architecture and a C-terminal immunoglobulin-like domain.

8 The RhoA-binding site was mapped to the Trio immunoglobulin-like domain.

9 eptor, Flt-1 (or VEGFR-1), consists of seven immunoglobulin-like domains.

10 MHVR and Bgp1(b) comprised of the first two immunoglobulin-like domains.

11 elf-aggregate but did not bind to any of the immunoglobulin-like domains.

12 plasmic chaperones that are comprised of two immunoglobulin-like domains.

13 coprotein consisting of 318 aa including two immunoglobulin-like domains.

14 titin and most likely involves unfolding of immunoglobulin-like domains.

15 riking resemblance to the all-beta Greek key immunoglobulin-like domains.

16 istinctive bend between the second and third immunoglobulin-like domains.

17 inhibitory immunoreceptors that bear C2-type immunoglobulin-like domains.

18 a second cysteine-rich motif followed by two immunoglobulin-like domains.

19 efacept is a chimeric protein combining CD58 immunoglobulin-like domain 1 with human IgG1 Fc.

20 Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a pan-ErbB nega

21 Here, we found that leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is highly expresse

22 receptor antagonist leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1), for further study

23 Leucine-rich repeats and immunoglobulin-like domains-1 (LRIG1) is a transmembrane

24 iant of FGF receptor 1 (FGFR1) consisting of immunoglobulin-like domains 2 (D2) and 3 (D3) has been d

25 2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF re

26 in LRIG2, encoding leucine-rich repeats and immunoglobulin-like domains 2, a protein implicated in n

27 , heparanase 2, and leucine-rich repeats and immunoglobulin-like domains-2 (LRIG2), which is mutated

28 exons, IIIc and IIIb, for the second half of immunoglobulin-like domain 3 (D3) in FGFRs.

29 Leucine-rich repeats and immunoglobulin-like domains 3 (Lrig3) was identified by

30 t of several different species revealed that immunoglobulin-like domain 4 is the most conserved extra

31 iated molecule"), contains two extracellular immunoglobulin-like domains, a transmembrane domain, and

32 edicted protein containing two extracellular immunoglobulin-like domains, a transmembrane segment, an

33 The second domain is close to the second immunoglobulin-like domain (amino acid residues 342-394)

34 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail contai

35 e protein that contains a novel six-cysteine immunoglobulin-like domain and a mucin domain; it is nam

36 The ectodomain of MuSK comprises three immunoglobulin-like domains and a cysteine-rich domain (

37 ansmembrane protein with three extracellular immunoglobulin-like domains and a cytosolic tail contain

38 plasma membrane glycoprotein containing two immunoglobulin-like domains and a single charge-containi

39 dothelial cell-specific receptors with seven immunoglobulin-like domains and a split kinase domain.

40 hydrophobic interface between the two C2-set immunoglobulin-like domains and parallel pairing of thei

41 t has not been reported in tandem repeats of immunoglobulin-like domains and that is presumably conse

42 riant of human peroxidasin 1 comprising four immunoglobulin-like domains and the catalytically active

43 rane proteins that contain two extracellular immunoglobulin-like domains and therefore belong to this

44 f a putative extracellular segment with five immunoglobulin-like domains and three fibronectin III-li

45 he predicted beta-strand c and d of hIL-18BP immunoglobulin-like domain, and most had hydrophobic sid

46 threonine kinase domain, two SH3 domains, an immunoglobulin-like domain, and spectrin-like repeats.

47 eletion of neuregulin isoforms containing an immunoglobulin-like domain are myasthenic.

48 ess, whereas sequences in or near the fourth immunoglobulin-like domain are required for interaction

49 All methods indicate that the extracellular immunoglobulin-like domains are monomeric in solution an

50 LIR-1 D1D2 is composed of two immunoglobulin-like domains arranged at an acute angle t

51 ke related immune receptors, GPVI contains 2 immunoglobulin-like domains arranged in a perpendicular

52 r graphics models of the human TrkA and TrkC immunoglobulin-like domains as a guide, the residues inv

53 LT-1 extracellular domain, suggest that this immunoglobulin-like domain autonomously plays an as yet

54 The LigB immunoglobulin-like domain binds to the 17th to 27th exo

55 It consists of two immunoglobulin-like domains bisected by a subunit bindin

56 of all three domains belongs to the I-set of immunoglobulin-like domains, but shows several unusual f

57 ular fragment of TLT-1 consists of a single, immunoglobulin-like domain connected to the platelet cel

58 lipoprotein remnant receptor family known as immunoglobulin-like domain containing receptor 1 (ILDR1)

59 ILDR1 encodes the evolutionarily conserved immunoglobulin-like domain containing receptor 1, a puta

60 LRIG1 (leucine-rich repeat and immunoglobulin-like domain containing), a member of the

61 mbrane glycoprotein, with four extracellular immunoglobulin-like domains containing three intrachain

62 f these deviations in the sequences of other immunoglobulin-like domain-containing receptors may help

63 res revealed a collagen-binding site in each immunoglobulin-like domain (D1 and D2).

64 This molecule contains four tandem external immunoglobulin-like domains (D1-D4), a transmembrane dom

65 extracellular portion of CD4 comprises four immunoglobulin-like domains (D1-D4).

66 The hSC structure comprises five immunoglobulin-like domains (D1-D5) arranged as a triang

67 and an extracellular region comprising five immunoglobulin-like domains (D1-D5).

68 ar portion of CAR comprises two glycosylated immunoglobulin-like domains, D1 and D2.

69 g site on the apical surface between the two immunoglobulin-like domains (D1D2) of the receptor and s

70 lar portion of the protein contains a single immunoglobulin-like domain displaying 46% sequence ident

71 Moreover, the presence of the first immunoglobulin-like domain encoded by another alternativ

72 The second immunoglobulin-like domain, encoded by exon 4, was requi

73 nal actin-binding domain and 24 filamin-type immunoglobulin-like domains (FLN) that form tail-to-tail

74 f 528 amino acids and contains three C2-type Immunoglobulin-like domains followed by one fibronectin

75 with an extracellular region composed of two immunoglobulin-like domains followed by two fibronectin

76 and a new and unexpected arrangement of four immunoglobulin-like domains forming a horseshoe.

77 clude the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit.

78 hicken CAR, or with the heterologous type C2 immunoglobulin-like domain from IgSF11, another IgSF mem

79 in malignant transformation, we removed two immunoglobulin-like domains from the extracellular domai

80 A number of beta-sandwich immunoglobulin-like domains have been shown to fold usin

81 ker between the IgII and IgIII extracellular immunoglobulin-like domains, have been documented in mor

82 [HveC(143t)], two [HveC(245t)], or all three immunoglobulin-like domains [HveC(346t)] of the extracel

83 Attempts to identify which of the five immunoglobulin-like domains (Ig I-V) and the two fibrone

84 inly of three segment types: serially linked immunoglobulin-like domains (Ig segments), interrupted b

85 ure of the agrin-responsive first and second immunoglobulin-like domains (Ig1 and Ig2) of the MuSK ec

86 sialylation of the N-glycans on the adjacent immunoglobulin-like domain (Ig5), and acidic residues on

87 A protein consisting of the fifth immunoglobulin-like domain (Ig5), which contains the rep

88 nd IIIc, which form the extracellular, third immunoglobulin-like domain (IgIII) and adjacent linker r

89 The extracellular domain of Tvc contains two immunoglobulin-like domains, IgV and IgC, which presumab

90 engage a conserved hydrophobic groove in the immunoglobulin-like domain III (D3) of the "c" splice is

91 In this postfusion conformation, the immunoglobulin-like domain III (DIII) and the stem regio

92 ing exons encoding the COOH-terminal half of immunoglobulin-like domain III and the transmembrane dom

93 otein containing leucine-rich repeats and an immunoglobulin-like domain in its extracellular region,

94 The second immunoglobulin-like domain in the extracellular domain o

95 d by six leucine-rich repeat domains and one immunoglobulin-like domain in their extracellular moieti

96 Tandem arrays of immunoglobulin-like domains in humans show significantly

97 eptor tyrosine kinase that consists of seven immunoglobulin-like domains in its extracellular portion

98 s in or near the first of four extracellular immunoglobulin-like domains in MuSK are required for agr

99 epsilon 3 and C epsilon 4 in IgE and the two immunoglobulin-like domains in the alpha-chain of Fc eps

100 CAM), a transmembrane glycoprotein with four immunoglobulin-like domains in the murine biliary glycop

101 , both elastin and HTE bind to the same LigB immunoglobulin-like domains, including LigBCon4, LigBCen

102 ot observed with Trio constructs lacking the immunoglobulin-like domain, indicating that RhoA acts to

103 arge modular protein composed mainly of many immunoglobulin-like domains, is a potent cross-linker of

104 unoglobulin-related receptors (KIR) with two immunoglobulin-like domains (KIR2D) modulate the lysis o

105 in (IL)-1 receptors with three extracellular immunoglobulin-like domains, limited homology (28%), and

106 Like titin, obscurin contains multiple immunoglobulin-like domains linked in tandem, but in con

107 Downstream of this domain was an immunoglobulin-like domain of 89 amino acids.

108 ricted to regions encoding the extracellular immunoglobulin-like domain of CD79b.

109 monstrated that seven amino acids within the immunoglobulin-like domain of hIL-18BP were important fo

110 Here we demonstrate that the sixth immunoglobulin-like domain of human L1 (L1-Ig6) can func

111 rmed dimers, suggesting a role for the third immunoglobulin-like domain of HveC in oligomerization.

112 in the coding region of the first N-terminal immunoglobulin-like domain of ICAM-1, present at high fr

113 three-dimensional model of the extracellular immunoglobulin-like domain of ICOS was used to map the r

114 by mutation of an RGD sequence in the sixth immunoglobulin-like domain of L1.

115 sMHVR-Ig, which comprised the virus-binding immunoglobulin-like domain of MHVR fused to the Fc porti

116 fate chains and a specific site on the first immunoglobulin-like domain of PTPsigma.

117 udies show that a small portion of the first immunoglobulin-like domain of PVR contacts viral residue

118 of the LigA repeat region was limited to an immunoglobulin-like domain of the bacterial intimin bind

119 inserts into a hydrophobic pocket within the immunoglobulin-like domain of the GDI molecule leading t

120 roteins are similar except for an additional immunoglobulin-like domain of the phi29 protein.

121 A single immunoglobulin-like domain of the T-cell receptor (varia

122 The extracellular immunoglobulin-like domain of the Trk receptors adjacent

123 affecting a conserved residue in the second immunoglobulin-like domain of titin, was introduced in a

124 rystal structure of PlGF bound to the second immunoglobulin-like domain of VEGFR1 at 2.5 A resolution

125 an be applied in the structure prediction of immunoglobulin-like domains of diverse modular proteins.

126 indicate that 1C3 inhibits clustering of the immunoglobulin-like domains of GPVI on collagen/CRPs, a

127 While moieties in the immunoglobulin-like domains of L1 have been implicated i

128 ARD) is responsible for interacting with the immunoglobulin-like domains of MALT1.

129 e crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa r

130 All SynCAM genes encode proteins with three immunoglobulin-like domains of the V-set, C1-set, and I-

131 ns to investigate how misfolding between the immunoglobulin-like domains of titin is prevented.

132 cellular region of KDR is comprised of seven immunoglobulin-like domains, of which the first three ha

133 ding to the receptor occurs within the first immunoglobulin-like domain, or V-domain, of HveC.

134 The structure has tandem immunoglobulin-like domains positioned at an acute, 60-d

135 Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) marks inte

136 Computations of bending rigidities for immunoglobulin-like domain proteins reveal no clear sepa

137 ns comprising its extracellular portion, the immunoglobulin-like domain proximal to the membrane (Trk

138 an antagonist that interacts with the fourth immunoglobulin-like domain reduced LTP when applied befo

139 truncated form of TRKB containing the second immunoglobulin-like domain (residues 248-398) was expres

140 s of two main segment types: serially linked immunoglobulin-like domains (tandem Ig segments) interru

141 s implies that the amino acids in the second immunoglobulin-like domain that determine Trk specificit

142 egulin-1 form has a distinct heparin-binding immunoglobulin-like domain that enables it to adhere to

143 Gamma-HRG contains the EGF-like and immunoglobulin-like domains that are commonly found in o

144 FcalphaRI has two immunoglobulin-like domains that are oriented at approxi

145 mbrane protein containing five extracellular immunoglobulin-like domains that is structurally related

146 mino acids at corresponding positions in its immunoglobulin-like domain, the exceptions being the con

147 ed that siglec-5 contains four extracellular immunoglobulin-like domains, the N-terminal two of which

148 spite previous assignment to the C2 class of immunoglobulin-like domains, the structure of IgD1 revea

149 e complex shows how AlkC uses unique HLR and immunoglobulin-like domains to induce a sharp kink in th

150 racellular domain of KIM-1 is composed of an immunoglobulin-like domain topping a long mucin-like dom

151 a functional adhesive site within the first immunoglobulin-like domain (V domain) of nectin-1.

152 ain an extracellular region comprising three immunoglobulin-like domains (V-set amino-terminal domain

153 tructure shows that s-IL1R consists of three immunoglobulin-like domains which wrap around IL-1beta i

154 mum set of residues in the human TrkC second immunoglobulin-like domain, which does not bind nerve gr

155 The overall fold consists of two immunoglobulin-like domains with an acute interdomain hi

156 ving the major beta sheets of the respective immunoglobulin-like domains with poor shape complementar

157 m Ig segments (consisting of serially linked immunoglobulin-like domains) with the unique PEVK segmen