ライフサイエンスコーパス: immunologic

1 features of the disease, including fibrosis, immunologic abnormalities, and endothelial dysfunction.

2 rmal tight junctions and did not exhibit any immunologic abnormalities, indicating that interactions

3 tion with MITF was measured before and after immunologic activation.

4 istinct T cell subsets are tailored to their immunologic activities.

5 to assess the pharmacokinetics and in vitro immunologic activity of the different dosing regimens.

6 sistance and shifted the focus to markers of immunologic activity with greater success.

7 colorectal cancer and have shown evidence of immunologic activity.

8 ial species and systematically analyzed host immunologic adaptation to colonization.

9 ly expand further afield to encompass unique immunologic adaptations.

10 ata suggests that recurrent NPC may had more immunologic advantage than primary NPC, especially the G

11 Clinical and immunologic analysis of patients was also performed and

12 We performed molecular and immunologic analysis of patients with CID, anhidrosis, a

13 A and protein expression, SOCE measurements, immunologic analysis of peripheral blood lymphocyte popu

14 The underlying immunologic and cellular processes involved in driving f

15 the bronchial microbiome are associated with immunologic and clinical features of the disease.

16 on mutant alleles underlie several different immunologic and clinical phenotypes, which can be assign

17 nce of differential response by age, further immunologic and epidemiologic studies are needed.

18 s of Ugandan children designed to understand immunologic and genetic factors associated with neurocog

19 Conceivably, the immunologic and genomic footprint of this resistance is

20 of pan- and isoform-specific JAKi in mice by immunologic and genomic profiling.

21 timing and frequency of AD-MSC treatment on immunologic and graft survival as well as graft vasculop

22 is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms.

23 In all circumstances, immunologic and nonimmunologic mechanisms are thought to

24 hages can be either increased or depleted by immunologic and pharmacologic agents, at least in vitro,

25 s enabling tumors to grow, spread, and avoid immunologic and therapeutic destruction.

26 V-associated cancers may differ depending on immunologic and virologic context during development.

27 Immunologic and virologic responses to antiretroviral th

28 ent transplantation and to determine whether immunologic and/or clinical parameters may be predictive

29 ent transplantation and to determine whether immunologic and/or clinical parameters may be predictive

30 ilability, quality, and complications due to immunologic and/or infectious issues.

31 plain this phenomenon, including angiogenic, immunologic, and cellular dormancy.

32 tures: personalized care based on molecular, immunologic, and functional endotyping of the disease, w

33 rting at day 0 combined with close clinical, immunologic, and histologic monitoring.

34 With clear effects on physiologic, immunologic, and metabolic processes in human health, ab

35 nd their lungs were analyzed by biochemical, immunologic, and morphometric methods.

36 sses in CKD5 arterioles and of inflammatory, immunologic, and stress-response cascades in PD arteriol

37 Novel pharmacological, immunologic, and surgical therapies are leading to impro

38 red these regimens with respect to clinical, immunologic, and virologic outcomes using data from pros

39 We have developed an integrated immunologic approach to investigate the clinical relevan

40 t evidence of the clinical efficacy of novel immunologic approaches using biological agents in patien

41 n detail by using flow cytometry, functional immunologic assay transcriptional profiling, and antigen

42 Most of the immunologic assays confirmed a protective effect of H. p

43 al infarction patients, with detailed safety immunologic assessments and magnetic resonance imaging-b

44 Safety and immunologic assessments were performed, and long-term fo

45 ammation or from a common, yet-to-be-defined immunologic background leading to immune deviations.

46 Sensitization to HLA remains a significant immunologic barrier to successful transplantation.

47 ed xenograft rejection (DXR) becomes a major immunologic barrier to successful xenotransplantation.

48 Donor-specific antibodies create an immunologic barrier to transplantation.

49 guide the development of protocols for novel immunologic-based therapies.

50 nses in treatment-naive patients (used as an immunologic baseline) were compared with those in patien

51 environmental factors can contribute to the immunologic basis of allergic reactions, the molecular u

52 ality control, and may exhibit a distinctive immunologic behavior.

53 B7-H3, a region critical to its function in immunologic blockade and unique among anti-B7-H3 antibod

54 Upregulated genes clustered in immunologic, cell adhesion, and keratin-related processe

55 ect in these patients and characterize their immunologic cellular abnormalities.

56 Potential triggers of relapse are immunologic challenges and environmental insults, both o

57 Data support the similarity of efficacy and immunologic changes between children and adults treated

58 xamine in the GRASS trial the time course of immunologic changes during 2 years of sublingual and sub

59 ment, the overall pattern of hematologic and immunologic changes suggest that posttreatment reactions

60 the intestine is emerging as a new site for immunologic changes that affect whole-body metabolism.

61 s immunotherapy (SCIT) are biomarkers of the immunologic changes that can lead to treatment efficacy.

62 re are important age-related physiologic and immunologic changes that complicate the presentation, di

63 fter adjusting for clinical, histologic, and immunologic characteristics and treatment, we identified

64 a better understanding of the molecular and immunologic characteristics of SS has allowed for the id

65 e previously reported heterogeneity of local immunologic characteristics of tuberculous granulomas in

66 uvant within a fusion protein determines its immunologic characteristics.

67 The immunologic characterization comprises flow cytometry, E

68 Immunologic checkpoint blockade with ipilimumab, a monoc

69 /PD-L1 approaches will likely be used as new immunologic checkpoint blocking antibodies begin clinica

70 In this first evaluation of an immunologic checkpoint inhibitor in healthy HIV-1-infect

71 Programmed death 1 (PD-1) is an immunologic checkpoint that limits immune responses by d

72 ity of suitable matched donors and potential immunologic complications.

73 By understanding the immunologic composition of this gradient, more effective

74 etransplant recipients who often have unique immunologic condition and risk profile and represent an

75 Patients with PHTS were assessed for immunologic conditions, lymphocyte subsets, forkhead box

76 This article postulates potential immunologic consequences of inhibiting components of the

77 rove coverage for global virus variants, the immunologic consequences of this strategy have been poor

78 ity criteria that focus on pharmacologic and immunologic considerations in this patient population an

79 une response, correlated in humans to poorer immunologic control of infection and more severe disease

80 ined by slow viral expansion and inefficient immunologic control.

81 has been made recently in understanding host immunologic controls of bNAb induction and maturation in

82 l mechanistic studies helping to explain the immunologic correlates of food allergy and food desensit

83 Understanding immunologic correlates of protection generated in vaccin

84 Secondary end points included safety and immunologic correlative studies.

85 plementation decisions will likely depend on immunologic data and their long-term correlation with di

86 However, also for these agents, in vivo immunologic data in humans are largely lacking.

87 neic stem cell transplantation corrected the immunologic defect in 1 patient.

88 2m on other members of the MHC-I family, the immunologic defect is more extensive than in patients wi

89 milial phenotype variations, and the type of immunologic defects in NS were evaluated.

90 resentation, with combined developmental and immunologic defects, is associated with a combined defic

91 Serologic and immunologic deficits were most frequent in older HIV-inf

92 we provide the first extensive clinical and immunologic description of beta2m deficiency in 2 siblin

93 We investigated the immunologic differences between steroid-sensitive (SS) a

94 ially curative treatment for hematologic and immunologic diseases.

95 Hypertension is considered an immunologic disorder.

96 e for prevention or treatment of Th1-related immunologic disorders and have implications at the level

97 coidosis and celiac disease are both chronic immunologic disorders involving multiple organ systems,

98 ymphocytes play a central role in many human immunologic disorders, including autoimmune and alloimmu

99 This observed immunologic distinction between mothers of children with

100 d protein 4-Ig reducing disease symptoms and immunologic disturbance, resulting in increased survival

101 l at 3 years, reflecting a lack of a durable immunologic effect.

102 While the immunologic effectors stimulated by these naked HER2 ant

103 R2 and delivers of a variety of cytotoxic or immunologic effectors with great selectivity to these ca

104 ransduction inhibitors, which impede desired immunologic effects in vivo Cancer Res; 76(9); 2561-72.

105 TLA-4 alone, or in combination have distinct immunologic effects in vivo.

106 However, the full scope of clinical and immunologic effects of CCR5 blockade in HSCT has not bee

107 sought to evaluate the clinical, safety, and immunologic effects of EPIT for the treatment of peanut

108 er, evidence in humans is circumstantial, as immunologic effects of norepinephrine have not been inve

109 To study the immunologic effects of this approach, we characterized b

110 ain n-3 polyunsaturated fatty acids can have immunologic effects on the developing fetus through seve

111 r, RAS activation in hematopoietic cells has immunologic effects that diverge from those of RAS stimu

112 There is a high unmet medical need to define immunologic endotypes of AD because it has significant i

113 Because parasite infections elicit a similar immunologic environment as allergic diseases, the associ

114 emerged as important in cancer pathogenesis, immunologic escape, and resistance to therapy.

115 solution of select AEs (those with potential immunologic etiology), and impact of select AEs and supp

116 Immunologic evaluation included assessment of serum trou

117 ic cause of MHC-I deficiency, but no further immunologic evaluation was performed.

118 Clinical, virologic, and immunologic evaluations were performed at baseline and e

119 nduction of bnAbs is to define the viral and immunologic events that occur during HIV-1 infection, an

120 ctive of viral set point, offering the first immunologic evidence of CD8(+)T cell dysfunction during

121 outcomes are determined by molecular and/or immunologic factors and identification of tumor/microenv

122 The immunologic factors contributing to these favorable outc

123 The role of immunologic factors in the development of gastrointestin

124 Here we develop the idea that immunologic factors influence the appearance of GI cance

125 t is essential that we understand better the immunologic factors underlying both original antigenic s

126 Nutritional, socioeconomic, and immunologic factors were assessed by logistic regression

127 Immunologic factors were highly significant predictors o

128 VL confirmation of immunologic failure is more effective and less costly th

129 for SOC, 16.97 years with VL confirmation of immunologic failure, and 17.25 years for adaptive VL.

130 ffective murine model to facilitate study of immunologic features of ABOi transplantation and to impr

131 We sought to describe the molecular and immunologic features of beta2m deficiency in 2 Turkish s

132 ized the clinical, laboratory, virologic and immunologic features of KICS by evaluating symptomatic a

133 nd memory B cells and recapitulated abnormal immunologic features typical of patients with CVID with

134 ZIKV infection was supported by clinical and immunologic findings.

135 t only as a physical barrier, but also as an immunologic first line of defense.

136 n together, our study suggests that CLL cell immunologic function is not only modulated by microenvir

137 ught to explore the expression and potential immunologic function of the tryptophan metabolism enzyme

138 D56(+)) were analyzed regarding DC, specific immunologic function, occurrence of systemic reactivatio

139 ractions between host nutritional health and immunologic function, which contribute to the varied phe

140 y, the effect of IL-15 SA on physiologic and immunologic functions of mice was evaluated.

141 ts and osteocytes have their own independent immunologic functions.

142 We performed immunologic, genetic, and biochemical studies in the pat

143 We used a combination of immunologic, genetic, microarray, and pharmacologic appr

144 Immunologic graft rejection is one of the main causes of

145 bility for cure because of the potential for immunologic graft-versus-lymphoma effect, but there are

146 lassification that includes the clinical and immunologic heterogeneity of these patients.

147 allude to the possibility of restoration of immunologic homeostasis and thus a state of tolerance as

148 which ultimately regulate both metabolic and immunologic homeostasis in the adipose tissue niche.

149 results implicate a possible contribution of immunologic host effects in accounting for the therapeut

150 disease of the small intestine caused by an immunologic hypersensitivity reaction to dietary wheat g

151 gene-level computational methods, as well as immunologic hypotheses, can help narrow down this genome

152 nsplant approach that takes advantage of the immunologic immaturity and normal developmental properti

153 o apoptosis are 2 mechanisms contributing to immunologic improvement following viral suppression in p

154 d suggest that, in this type of drug-induced immunologic injury, the primary reaction involves bindin

155 Modulation of immunologic interactions in cancer tissue is a promising

156 Here we discuss emerging views on immunologic interactions occurring in the lungs for M. t

157 A major approach for immunologic intervention in tuberculosis involves redire

158 and as such represent important targets for immunologic intervention.

159 The development of immunologic interventions that can target the viral rese

160 In the search for effective immunologic interventions to prevent and treat HIV-1 inf

161 ility of whole-genome analyses combined with immunologic investigation in patients with unresolved im

162 y function impairment and progressive and/or immunologic kidney disease.

163 otential for causing harmful postvaccination immunologic (Koch-type) reactions.

164 We sought to construct the immunologic landscape in the airways of children with se

165 nal hypersensitivity pneumonitis (OHP) is an immunologic lung disease resulting from lymphocytic and

166 cell markers CD44, CD133, and c-Met and the immunologic markers human leukocyte antigen class II and

167 , this option historically provided a better immunologic match.

168 e control occurs through chemotherapeutic or immunologic means, which decrease or prevent transmissio

169 lative studies support, at least in part, an immunologic mechanism of activity.

170 of developing tuberculosis, but the precise immunologic mechanism of Mycobacterium tuberculosis cont

171 Little is currently known regarding the immunologic mechanism(s) that initiate peanut allergy.

172 cted in more precise ways to target specific immunologic mechanisms and pathways.

173 une dysregulation, and describe the possible immunologic mechanisms behind causes and consequences of

174 el for peanut allergy and to investigate the immunologic mechanisms involved in peanut allergen sensi

175 We sought to study the immunologic mechanisms of action for novel vaccines targ

176 ss new research leading to understanding the immunologic mechanisms of bnAb induction, and address is

177 teractions and, as well, led to insight into immunologic mechanisms of control of bnAb development.

178 ification of IgE facilitated the analysis of immunologic mechanisms of reaginic hypersensitivity.

179 dings evoke the possibility of unanticipated immunologic mechanisms subtending the potent antitumor e

180 iew of the range of possible biochemical and immunologic mechanisms that may contribute to the differ

181 for food allergy hold promise; however, the immunologic mechanisms underlying these therapies are no

182 gene-deficient mice were used to dissect the immunologic mechanisms.

183 fectively with therapy and generated durable immunologic memory.

184 ormal physiologic processes that provide for immunologic memory.

185 ADCs also induced immunologic memory.

186 n vivo and to have the capacity to establish immunologic memory.

187 We used radiometric, immunologic, metabolomic, and biochemical assays to meas

188 mic nervous system dysfunction, genetics and immunologic/microbiome.

189 matous inflammation and address the aberrant immunologic milieu arising in a mouse model of filaggrin

190 ed and AIDS patients should be combined with immunologic monitoring, enhancement of coverage of HIV-t

191 lasma asprosin, and its loss of function via immunologic or genetic means has a profound glucose- and

192 admission are most commonly due to surgical, immunologic, or infectious complications.

193 Immunologic outcomes included measurement of basophil CD

194 Immunologic outcomes included measurement of spontaneous

195 been implemented to monitor TMA exposure and immunologic outcomes.

196 ssessed for clinical sensitivity to OVA, and immunologic parameters were assessed.

197 Clinical, microbiologic, and immunologic parameters were statistically analyzed.

198 the wild-type virus and disease severity and immunologic parameters were studied.

199 parameters, as well as a slight influence on immunologic parameters, signaling the need for additiona

200 nction, hearing and vestibular function, and immunologic parameters.

201 overview of the current understanding of the immunologic pathophysiology of sepsis, followed by a det

202 pproach is likely to provide an insight into immunologic pathways and mechanisms of disease.

203 cGVHD, suggesting that aGVHD may invoke the immunologic pathways responsible for cGVHD.

204 Investigation of the immunologic pathways underlying allergic sensitization t

205 y fundamental questions about this important immunologic phenomenon.

206 ences that help to explain the wide range of immunologic phenotypes that result from different mutati

207 associations between filaggrin mutations and immunologic phenotypes.

208 ia FcepsilonRI, we identified three distinct immunologic phenotypes.

209 -expressing CD8(+) T cells was the strongest immunologic predictor of future SCC and correlated with

210 aborted HIV infections providing a source of immunologic priming.

211 has demonstrated that it is fundamentally an immunologic process that ultimately results in inflammat

212 based approach to understand the genetic and immunologic processes controlling the development of HIV

213 ool for understanding the biology of diverse immunologic processes.

214 SC (AdMSC) display and induce a differential immunologic profile, upon ongoing AdMSC suppressive acti

215 es in infants are associated with a distinct immunologic profile.

216 concentration of IL-10 without changing the immunologic profile.

217 d hypoglycemic events, and induced favorable immunologic profiles at 24 months, well over 1 year afte

218 tumors are uniform in that they have complex immunologic profiles, which allow them to escape immune

219 ver, some HIV-1-controllers have evidence of immunologic progression with marked CD4(+)T-cell decline

220 ntification of HIV-1-controllers at risk for immunologic progression, and provide avenues for persona

221 ompromised patients had similar VZV-specific immunologic properties except for lower T-cell frequenci

222 Anti-inflammatory and immunologic properties of cannabinoids have been reporte

223 Immunologic properties were characterized in vitro by us

224 ge over norepinephrine with respect to their immunologic properties.

225 esentation, thereby influencing an antigen's immunologic properties.

226 Correlates of immunologic protection requisite for an efficacious herp

227 Genetic, immunologic, protein, and cellular functional analyses w

228 onic ischemic cardiomyopathy without adverse immunologic reaction.

229 In this study, posttreatment clinical and immunologic reactions were compared following single-dos

230 motes cardiac regeneration without provoking immunologic reactions.

231 r the use of preparative chemotherapy, other immunologic reconstitution parameters were not affected,

232 LV-mediated GT allowed immunologic reconstitution, although it was suboptimal c

233 As such, they offer the prospect of immunologic rehabilitation and a platform from which to

234 ninvasive biomarker platforms for monitoring immunologic rejection.

235 None of the patients had graft infection or immunologic rejection.

236 Objective: To investigate whether immunologic response to HPV16 is associated with patient

237 To investigate whether immunologic response to HPV16 is associated with patient

238 occurs in HLA-Cw6(+) patients, the specific immunologic response to this innate stimulus that causes

239 itive reporter systems that do not induce an immunologic response would provide useful information.

240 ble, well-tolerated, and capable of inducing immunologic responses against tumor cells.

241 Cancer and sepsis have surprisingly similar immunologic responses and equally dismal long term conse

242 differences in physiologic, tumorigenic, and immunologic responses between the two ablative modalitie

243 Probiotics have been hypothesized to affect immunologic responses to environmental exposures by supp

244 Immunologic responses to the vector and transgenic prote

245 ial increased protection against malaria and immunologic responses.

246 lls were analyzed for regulatory T cells and immunologic responses.

247 derstand the molecular mechanisms underlying immunologic responses.

248 rol group including 39 patients with a lower immunologic risk (MFI between 500 and 3000 at day 0) who

249 Our high immunologic risk program included 95 patients with high

250 ted mismatches in isolation confer increased immunologic risk.

251 primary cells, were used to investigate the immunologic role of KYNU and tryptophan metabolites.

252 The broad immunologic roles of autophagy span innate and adaptive

253 5(+) T cells are critical for maintenance of immunologic self-tolerance.

254 tor FOXP3 play a pivotal role in maintaining immunologic self-tolerance.

255 broadly expressed; intersects two important immunologic signaling networks; and impacts autoimmunity

256 ibody competition profile could represent an immunologic signature of protection.

257 We sought to identify a specific immunologic signature that predicted protection from sub

258 ably, microarray studies revealed absence of immunologic signatures of rejection in most isolated end

259 oth graft loss and rejection, independent of immunologic stability, etiology, and immunosuppression t

260 vides a high-level assessment of a patient's immunologic state and guides the diagnosis and treatment

261 potential and caution and reflection of the immunologic state at the time of conversion.

262 s that result in interruption of the default immunologic state of tolerance.

263 sitivity, and specificity in detecting graft immunologic status, superior to CCT.

264 known to respond to both innate and adaptive immunologic stimuli.

265 ot be sustained in the presence of an innate immunologic stimulus, such as IL-33.

266 In vitro immunologic studies performed on subjects' baseline PBMC

267 Immunologic studies were carried out by means of flow cy

268 g a combination of genomics, proteomics, and immunologic studies, we investigated the role of MR and

269 s, which may allow further physiological and immunologic studies.

270 tients with CU can be categorized into three immunologic subgroups based on their basophil reactivity

271 Purpose Immunologic surveillance of minimal residual disease in

272 ay be atheroprotective inducing a Th1-to-Th2 immunologic switch.

273 describe two brothers with hematopoietic and immunologic symptoms reminiscent of Wiskott-Aldrich synd

274 Polarization of granzyme B to the immunologic synapse and interaction of mutant Rab27A (p.

275 molecular contacts to possibly stabilize the immunologic synapse and potently induce antibody-depende

276 Decreasing the cortical actin density at the immunologic synapse or decreasing the lytic granule size

277 zation of the actin meshwork openings at the immunologic synapse revealed that the cortical actin act

278 e IS but could be exocytosed on reaching the immunologic synapse.

279 d delayed granzyme B polarization toward the immunologic synapse.

280 phosphatase network that is polarized at the immunologic synapse.

281 polarization, and recruitment of PTEN to the immunologic synapse.

282 ncreased in size but able to polarize to the immunologic synapse; however, they were unable to proper

283 indicating that these genes might be primary immunologic targets involved in DXR.

284 cytes with cell lines prior to molecular and immunologic tests.

285 eutics and targeted molecular, cellular, and immunologic therapies, it is important to identify diffe

286 as epigenetic, noncoding-RNA, and cell-based immunologic therapies.

287 nistration of IL-33 with an antigen impaired immunologic tolerance in the lungs that had been establi

288 to investigate how IL-33 affects established immunologic tolerance in vivo.

289 to key roles for both central and peripheral immunologic tolerance mechanisms in limiting bnAb develo

290 IgG antibodies can act to induce and sustain immunologic tolerance to foods.

291 33 dysregulated lung Treg cells and impaired immunologic tolerance to inhaled antigens.

292 d in affecting previously established airway immunologic tolerance.

293 to environmental antigens generally leads to immunologic tolerance.

294 Immunologic treatment failure was moderate to substantia

295 Overall, 30.4% had immunologic treatment failure with cumulative treatment

296 WHO criteria were used to define immunologic treatment failure.

297 An effect of these immunologic treatments on pruritus and the disturbed mic

298 and the increasing success of strategies in immunologic tumor therapy, which include checkpoint inhi

299 Here, we review the immunologic underpinnings of Treg therapy and technical

300 Although its mechanism (immunologic vs nonimmunologic) remains unclear, this fin