ライフサイエンスコーパス: immunological

1 le expression of skeletal, neurological, and immunological abnormalities.

2 ter a diagnosis has been made based on extra-immunological abnormalities.

3 bstinence reversed most, but not all, of the immunological abnormalities.

4 including maternal infection and subsequent immunological activation may increase the risk of autism

5 phagocytosis, suggesting a range of anti-HIV immunological activities, warranting further clinical tr

6 However, the origin of its immunological activity is still unknown.

7 Interestingly, the immunological activity of RT does not exhibit linear dos

8 Its immunological activity resided in the phytosphingosine t

9 peripheral nerves exerts its biological and immunological activity via high-affinity neurokinin 1 re

10 Thus, we sought to determine whether immunological activity would influence myocardial struct

11 However, RT also mediates consistent immunological activity, not only as an "on-target effect

12 Therefore, metabolic and immunological alterations associated with chronic oral c

13 tigenicity, apparently by inducing selective immunological amnesia.

14 Immunological analyses revealed that the induction of EA

15 d at multiple time points, and comprehensive immunological analyses were performed.

16 Immunological analysis confirmed the found abundance dif

17 Immunological analysis shows that while the CTLs express

18 d on pharmacokinetics, target occupancy, and immunological analysis, we chose 10 mg/kg every 2 weeks

19 ave the potential to quantify physiological, immunological and behavioural responses of livestock and

20 reatment protection and more tolerance-prone immunological and epigenetic modifications than OIT alon

21 The immunological and histological analysis confirmed the po

22 microglia, and they play important roles in immunological and inflammatory processes.

23 ing tumor cells and supports tumor growth by immunological and metabolic mechanisms.

24 (TB), as well as to identify the fundamental immunological and molecular mechanisms affected by SP110

25 le abnormal JAK1 activity has been linked to immunological and neoplastic diseases.

26 ruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian mi

27 nisms, LMW agents appear to act through both immunological and non-immunological mechanisms.

28 ransepithelial migration and other important immunological and physiological processes at the mucosal

29 erpretation of serial tests is confounded by immunological and technical variability.

30 lure (TF) patients with respect to clinical, immunological and virological characteristics.

31 a provide the host with the right metabolic, immunological, and neurological components to support he

32 Here, we describe the surgical, immunological, and neurorehabilitation details with func

33 advancement of biotechnology, molecular and immunological approaches have revolutionized fungal dise

34 he host response to MERS-CoV infection using immunological assays and transcriptome analysis.

35 to their potential in the development of non-immunological assays with high sensitivity, affinity and

36 aintain robustness and reproducibility among immunological assays.

37 ophagoides farinae, and in standard cellular immunological assays.

38 Here, we report the immunological assessment of novel and economically manuf

39 Even with this accomplishment, addressing immunological barriers to transplantation remains a majo

40 disease in otherwise healthy people, but the immunological basis for this remains unexplained.

41 Glycation of food allergens may alter their immunological behaviour.

42 es could experience stronger demographic and immunological benefits from provisioning that affect par

43 To assess how fungal immunological biomarkers are related to fixed airflow ob

44 atacept- and tacrolimus-treated patients and immunological biomarkers for acute rejection were invest

45 ed with major depressive disorder (MDD), and immunological biomarkers of depression remain a focus of

46 cell lines) have been used to determine the immunological capacity of the ligand, by measuring cell

47 Allergy immunotherapy targets the immunological cause of allergic rhinoconjunctivitis and

48 an antiangiogenic drug, but it also acts on immunological cells.

49 eceptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance

50 emory T cells, is one of the most consistent immunological changes in humans during aging.

51 The examination of the immunological changes observed during the establishment

52 of APCs in distinct tissues, influencing the immunological character of allergic inflammation.

53 sed preschool children may have clinical and immunological characteristics more amenable to treatment

54 However, the immunological characteristics of Amb a 1 isoforms are no

55 ommon variable immunodeficiency, while extra-immunological characteristics were not apparent at that

56 of the T cell antigen receptor (TCR) and of immunological-checkpoint molecules such as 4-1BB, PD-1 a

57 enomic variation, repeat vaccination, birth (immunological) cohort effects, and potential within-seas

58 Immunological comparison was carried out using Western b

59 addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species t

60 inherently intricate surgical technique and immunological complexity.

61 comprised in SMA, we analyzed the spleen and immunological components in SMA mice.

62 investigated the physical, biochemical, and immunological components of retinal injury after alkali

63 ntrol and elimination activities may enhance immunological conditions for the expansion of artemisini

64 to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations

65 r translational studies on the metabolic and immunological consequences of glucocorticoid-associated

66 The immunological consequences of IFN activation, while impo

67 Immunological control may contribute to achievement of d

68 uired for the host to establish an effective immunological control.

69 de new mechanistic insight into the historic immunological conundrum for how Tcrb allelic exclusion i

70 Several groups have demonstrated immunological cross-reactivity between ZIKV and other fl

71 Glucose-based PD fluids reduce immunological defenses in the peritoneal cavity.

72 tis E Virus (HEV) infections are limited and immunological determinants of viral persistence remain l

73 evelopment and suggests a potential role for immunological development in SMA.

74 early in life, can perturb the metabolic and immunological development of lab mice.

75 our current understanding of the homeostatic immunological dialogue between the host and its microbio

76 ucocorticoid (steroid) treatment to identify immunological differences between steroid-sensitive (SS)

77 on of host genetic and nongenetic factors to immunological differences in humans remains largely unde

78 Despite these immunological differences, Schistocephalus was equally s

79 anistic modeling to define new mechanisms of immunological disease and to accelerate the translation

80 screening, diagnosis, and treatment of human immunological disease.

81 correlated with the inflammatory response or immunological disease.

82 mpare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects

83 ry disease' in MF mononuclear cells, and in 'immunological diseases' in MF granulocytes.

84 d as a potential target for the treatment of immunological disorders.

85 ffective medical therapies against cancer or immunological disorders.

86 IFN-gamma-inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic G

87 tumor immune evasion, thereby serving as an immunological driver of tumorigenesis.

88 upplementation also changed the nutrient and immunological dynamics of host microbiota in responding

89 MCS recipients are debilitated and have some immunological dysfunction.

90 r continues, a cascade of events can trigger immunological dysfunction.

91 d sleep coalesces with specific hormonal and immunological dysregulations.

92 ledge on the basic mechanisms underlying the immunological effect of AIT is vast, the specific mechan

93 pendent cell-mediated phagocytosis (CDCP) by immunological effector molecules mediated the clearance

94 r delivery strategies to further enhance the immunological effects of doxorubicin has not been adequa

95 nearly 20 years ago as distinct clinical and immunological entities caused by dysregulation in the in

96 ysis of features of these antibodies and the immunological environment that enables their induction.

97 Immunological evaluations of the resultant conjugates in

98 This study provides the immunological evidence base for continuing annual influe

99 indings provide structural, biochemical, and immunological evidence that the bacterial epoxide hydrol

100 We then performed immunological experiments to measure in vitro cytokine p

101 We conducted a direct test of an immunological explanation of the finding that gay men ha

102 microbiome, and also metabolic, genetic, and immunological factors.

103 om a combination of intrinsic and extrinsic (immunological) factors.

104 ment in which anatomical, physiological, and immunological features act in concert to foster a partic

105 Trial designs should consider the distinct immunological features of each transplanted organ, Treg

106 atotropic infections in laboratory mice with immunological features resembling those seen in human vi

107 re unknown, but they may be linked to unique immunological features that allow bats to act as asympto

108 Varied immunological findings have been reported in children wi

109 These chemical and immunological findings provide new insights into antigen

110 edefinition of ADE in the context of complex immunological flavivirus interactions to provide a more

111 Data on long-term immunological follow up and vaccination responses after

112 Here we present long-term immunological follow up of a cohort of 55 lung transplan

113 m4 homolog with distinct differences in both immunological function and sensitivity to membrane compo

114 en together, these data demonstrate that the immunological function of IgA is substantially more exte

115 ew strategies for measuring a broad swath of immunological functions as a means of discovering previo

116 y its endogenous human promotor to study the immunological functions of POP2.

117 globulin G (IgG) mediates a wide spectrum of immunological functions that influence both innate and a

118 node periphery is an important site for many immunological functions, from pathogen containment to th

119 ent in mouse ILC except NK cells, defined by Immunological Genome Project studies, is significantly o

120 r HLA-matched cell transplantation to reduce immunological graft rejection.

121 CyTOF may, for example, uncover the immunological heterogeneity and differentiation of Lange

122 tically evaluate possibilities for restoring immunological homeostasis under conditions of metabolic

123 that would otherwise lead to a disruption of immunological homeostasis.

124 ell differentiation from HSCs by maintaining immunological homoeostasis in the bone marrow microenvir

125 tralizing antibodies as well as an antiviral immunological host response.

126 To address immunological IgE cross-reactivity on molecular level, s

127 been suggested that Tregs could restore the immunological imbalance in DED.

128 g microspheres are capable of overcoming the immunological imbalance of Tregs and CD4(+) IFN-gamma(+)

129 Immunological immaturity of the neonate might result in

130 Here, we summarize some of the immunological implications of HIV-1 diversity, and outli

131 de high proliferative activity, an increased immunological infiltrate, a basal-like and a mesenchymal

132 the impact of lymphatic biology in any given immunological interaction is a key step toward integrati

133 zed, such as adaptive viral genetic changes, immunological interactions with other circulating flaviv

134 A better understanding of the complex immunological interplay within the microenvironment is r

135 These observations offer a basis for immunological intervention to combat chronic infection w

136 This review synthesizes immunological knowledge derived from basic mouse studies

137 findings illustrate the complex genetic and immunological landscapes underpinning human interactions

138 uccessfully limit pathogen dissemination, an immunological link between the entry tissue of the patho

139 age subpopulation cell-surface expression of immunological markers and phagocytic ability were assess

140 class-restricted AHAs and their potential as immunological markers in healthy donors (HDs) and patien

141 lammatory arthritis; however, the underlying immunological mechanism remains unknown.

142 ghlights the importance in understanding the immunological mechanisms controlling this emerging infec

143 Although the immunological mechanisms driving this outcome are in nee

144 Immunological mechanisms involved in sensitization were

145 An in depth understanding of these complex immunological mechanisms of protection against HIV-1 wil

146 The immunological mechanisms sustaining this response in the

147 studies are providing novel hypotheses about immunological mechanisms that may be responsible for pre

148 for antibody determination and describe the immunological mechanisms that may mediate antibody-induc

149 into host defenses against pathogens and the immunological mechanisms that most effectively fight inf

150 The immunological mechanisms underlying C-IRIS are incomplet

151 Immunological mechanisms underlying OR differ according

152 To investigate immunological mechanisms underlying the boosting of alle

153 AllergoOncology that aims to delineate these immunological mechanisms with juxtaposed clinical conseq

154 be mediated in part by antiviral as well as immunological mechanisms.

155 ar to act through both immunological and non-immunological mechanisms.

156 -specific Vgamma4 cells function in adaptive immunological memory against B. pertussis.

157 ting in cure of some mice and development of immunological memory against B78 and wild type B16 tumor

158 The mice cured from ReACT also developed immunological memory against tumor rechallenge.

159 Understanding immunological memory formation depends on elucidating ho

160 brates, insects use immune cells to generate immunological memory in the form of stable vDNAs that ge

161 Mathematical modeling reveals that long-term immunological memory is maintained in a manner that is e

162 n is currently available regarding prolonged immunological memory post-RABV vaccination.

163 Characterising the longevity of immunological memory requires establishing the rules und

164 e propose a model of T cell memory, in which immunological memory state is encoded epigenetically, th

165 uality of humoral immunity and generation of immunological memory to vaccines is critical for protect

166 vailable regarding the mechanisms underlying immunological memory, which can broaden humoral response

167 nt T cells in vitro, suggesting long-lasting immunological memory.

168 i-CTLA-4 Ab to achieve tumor eradication and immunological memory.

169 , thereby providing the host with long-lived immunological memory.

170 partment as a potential major contributor to immunological memory.

171 Current immunological methods enable only steady-state detection

172 The portal circulation has a distinct immunological milieu characterised by a pathological neu

173 estigated the impact of IDH mutations on the immunological milieu in LGG.

174 ot) laboratory mice as a useful and relevant immunological model system.

175 nalization with poly(ethylene glycol) and/or immunological modulators, prevent robust macrophage reco

176 and quaternary structure with functional and immunological mutational analysis across E1E2 in order t

177 Regulatory signals provide negative input to immunological networks promoting resolution of acute and

178 innate immunity foundation on which complex immunological novelties arose.

179 fits that might depend on both on-target and immunological off-target effects.

180 does not worsen the short-term clinical and immunological outcomes of virally suppressed HIV-positiv

181 S using a Upsilon-retroviral vector improved immunological parameters substantially but were complica

182 ivation of MIP-1beta in NK cells as the four immunological parameters that best predict decreased inf

183 inical disability scores, viral markers, and immunological parameters were obtained for patients and

184 he immunoproteasome and outlines its role in immunological pathways and its potential in alloimmunity

185 several days after peak viraemia implicating immunological pathways.

186 Although generally beneficial from an immunological perspective in maintaining IgG populations

187 Immunological phenomena, including skewed cytokine produ

188 r events and resolution of hematological and immunological phenotype at a median follow-up of 18 mont

189 vels of GINS1 activity did not influence the immunological phenotype, which was uniform.

190 6 kinase are biologically active and induced immunological phenotypes consistent with T. gondii strai

191 Patients who present with unique immunological phenotypes provide an opportunity to bette

192 variety of disease states, as well as other immunological phenotypes, as a highly parallelizable dia

193 patients with a wide age range and different immunological phenotypes.

194 cts of the microbiome on innate and adaptive immunological players from epithelial cells and antigen-

195 antitative data into meaningful discovery of immunological principles, predictive models, and strateg

196 Allelic exclusion describes the essential immunological process by which feedback repression of se

197 , we first summarize what is known about the immunological process of HIV bnAb development, the chall

198 g of basic mycological, pharmacological, and immunological processes has led to important advances in

199 They demonstrate the importance of studying immunological processes in females and males separately

200 ute to many physiological, developmental and immunological processes in plants.

201 Our findings highlight unique immunological processes leading to BOS and RAS.

202 C-II)-restricted CD4(+) T cells are distinct immunological processes that are strictly MHC-II-depende

203 The cellular immunological processes that underlie the drug-specific

204 ly become clear that IgA also mediates other immunological processes, little remains known about the

205 ays involved in hepatic lipid metabolism and immunological processes.

206 late gene expression programs underlying key immunological processes.

207 owed statistically significant enrichment in immunological processes.

208 match rates in ICP and can provide a better immunological profile in CP recipients who have a high E

209 ntifies three T helper subsets with distinct immunological properties in both healthy individuals and

210 ents need to be tailored based on the unique immunological properties of this organ.

211 Here, we compared the physicochemical and immunological properties of three most important Amb a 1

212 Their immunological properties were further evaluated in vitro

213 opyranoside, which could possess interesting immunological properties.

214 immunity with vaccines is attractive for the immunological protection against pathogen entry directly

215 as chemical, biochemical, pharmaceutical and immunological purposes.

216 or was created to detect Brettanomyces using immunological reactions and impedance spectroscopy analy

217 surface passivation does not always prevent immunological reactions to 2D nanomaterials but also sug

218 cells (HSCs) induce hepatic inflammation and immunological reactions; we therefore investigated their

219 We thus propose GAS6 as a key immunological regulator of host-commensal interactions i

220 ants, gender mismatches have higher rates of immunological rejection.

221 Large-scale DNA sequencing of immunological repertoires offers an opportunity for the

222 Immunological requirements for rejection and tolerance i

223 ocytes of the brain and help orchestrate the immunological response by interacting with infiltrating

224 Cancer cells can induce an immunological response resulting in the production of tu

225 responsible for co-ordinating the peripheral immunological response to injury.

226 Most of the patients demonstrated an immunological response to pembrolizumab.

227 The definition of the immunological response to Zika (ZIKV) infection in human

228 We investigated the clinical and immunological response, focusing on the immune mediators

229 that is well known for triggering anti-tumor immunological response.

230 of urban pollution may prompt a more severe immunological response.

231 Immunological responses after stings varied in bee and v

232 nimal models to study HBV infection in vivo, immunological responses against the virus and viral path

233 While immunological responses associated with T1R have been in

234 ino acid catabolism in the modulation of the immunological responses in MS patients.

235 Nonetheless, a better understanding of the immunological responses induced by PD-1 blockade in canc

236 Recent efforts to dissect immunological responses to ZIKV have provided significan

237 These immunological responses were coincident with a suppressi

238 These robust immunological responses were sustained for 1 year.

239 natal regulatory B cells, thereby inhibiting immunological responses.

240 organ development, brain function and govern immunological responses.

241 oss and may be a useful tool to stratify the immunological risk for AMR.

242 We analyzed 598 standard immunological risk recipients.

243 phenotype of LTBI, providing a rationale for immunological risk stratification to improve targeting o

244 This work demonstrates a major immunological role for an endocannabinoid.

245 These findings reveal a non-immunological role of IL-17 modulating circuit function

246 atalysis remain elusive despite its critical immunological roles and off-target effects in tumorigene

247 derstanding of pathogenesis of diseases with immunological roots.

248 role in the establishment and maintenance of immunological self-tolerance and homeostasis.

249 LRP12 and the microbiome each contributed to immunological signaling that culminated in colon inflamm

250 The clinical and immunological significance of this finding is bidirectio

251 he door for investigating the biological and immunological significance of this glycosaminoglycan mod

252 h a severely active disease shows an overall immunological skin involvement showing a peculiar gene p

253 ferent germline origins arrive at equivalent immunological solutions to virus neutralization.

254 linked to host metabolic, developmental, and immunological states.

255 ch factors combine to represent the inherent immunological status - or 'cancer-immune set point' - of

256 of acute rejection, independent of age, era, immunological status, and initial immunosuppression.

257 gulated in response to various metabolic and immunological stimuli that promote macrophage M2 polariz

258 ion loads, this natural variation can reveal immunological strategies underlying adaptation to infect

259 o raw clinical and molecular data related to immunological studies has created a tremendous opportuni

260 ion conformation has hindered structural and immunological studies.

261 sources for further in-depth virological and immunological study.

262 This immunological switch defines a critical 'time window' fo

263 ular contact through the establishment of an immunological synapse (IS) between the NK cell and the t

264 lls because it initiates the assembly of the immunological synapse and mediates firm adhesion to the

265 into the area of cellular contact to form an immunological synapse from where T cell signaling is ini

266 trating the recruitment of LAT to the T-cell immunological synapse in data acquired by iPALM providin

267 tribution of the beta2 integrin LFA-1 to the immunological synapse is compromised in Cav1-knockout T

268 e (PIP2) and that alterations in PIP2 at the immunological synapse regulate cortical actin in CTLs, p

269 ligands, B cell Siglecs are recruited to the immunological synapse, resulting in suppression of BCR s

270 Building on previous studies at the T cell immunological synapse, we quantitatively assess the stru

271 of the fibrous actin meshwork at the T cell immunological synapse, whose structure has been shown to

272 of cytotoxic substances from granules at the immunological synapse.

273 istance that facilitates localization to the immunological synapse.

274 ing receptor turnover and maintenance of the immunological synapse.

275 ify the requirement of RIAM for formation of immunological synapses and in resulting T cell functions

276 nd exclude protein kinase C (PKC)-theta from immunological synapses formed on supported lipid bilayer

277 ing the formation of KIR2DS2 ligand-specific immunological synapses.

278 Current immunological techniques used to detect pathogens in pla

279 High-throughput immunological testing of such lymphocytes in combination

280 efore to design interventions that can break immunological tolerance and halt cancer progression, whe

281 discuss how metabolic workload can modulate immunological tolerance and review the molecular mechani

282 Importantly, experimentally breaching immunological tolerance in wild-type mice also leads to

283 ft is stably accepted, rejected, or achieves immunological tolerance is dependent on the frequency an

284 s for self-antigens and it has been proposed immunological tolerance may present a barrier to their p

285 Autoantigen-specific immunological tolerance represents a central objective f

286 Lastly, peripheral signs of altered immunological tolerance unfold in mutant mice and in imm

287 The achievement of immunological tolerance using helminth-derived products

288 early young adulthood, while an increase in immunological tolerance with aging suppresses disease on

289 ective and safe treatment in LAR, increasing immunological tolerance, and reducing the clinical sympt

290 likely depend, in part, on the induction of immunological tolerance, because the high levels of immu

291 ional heterogeneity is a critical feature of immunological tolerance.

292 ponse that later subsided suggested acquired immunological tolerance.

293 regnancy is one of the strongest inducers of immunological tolerance.

294 ory T cells (Tregs) are a central element of immunological tolerance.

295 -27 is pivotal to safeguarding Treg-mediated immunological tolerance.

296 The ability of microbes to set the immunological tone of tissues, both locally and systemic

297 Pr20 is an immunological tool and potential therapeutic agent.

298 ndidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in prec

299 NCE We developed several novel molecular and immunological tools to study the interactions among HCV,

300 In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut