ライフサイエンスコーパス: immunological synapse

1 es relevant to T cells, and translocation to immunological synapse).

2 ting cytotoxic granules for secretion at the immunological synapse.

3 r-target cell interface of the CD16-mediated immunological synapse.

4 olecules including the CD8 coreceptor to the immunological synapse.

5 f these phosphatases with ligated TCR at the immunological synapse.

6 to phosphorylate stathmin molecules near the immunological synapse.

7 get cells contacted by the T cell through an immunological synapse.

8 ll and an antigen-presenting cell termed the immunological synapse.

9 ters directly, that is, as they occur in the immunological synapse.

10 he transpresentation of IL-15 as part of the immunological synapse.

11 avidity of the beta(2) integrin LFA-1 in the immunological synapse.

12 ately drive receptor cluster dynamics at the immunological synapse.

13 ellular localization and its delivery to the immunological synapse.

14 required to efficiently recruit CD28 to the immunological synapse.

15 e T cell receptor (TCR) at the center of the immunological synapse.

16 lasma membrane directs lytic granules to the immunological synapse.

17 ese interactions promote the formation of an immunological synapse.

18 ules at the T cell-APC interface to form the immunological synapse.

19 rin and granzymes at the NK cell-target cell immunological synapse.

20 n of signaling molecules PKC- and lck at the immunological synapse.

21 PKC-theta was sequestered away from the Treg immunological synapse.

22 osphate (PI(4,5)P(2)) at the APC side of the immunological synapse.

23 and delayed CD3 epsilon localization to the immunological synapse.

24 tivation and signal transduction through the immunological synapse.

25 stalk region mediating the formation of the immunological synapse.

26 ell activation process through the so-called immunological synapse.

27 ough localization to the cSMAC region of the immunological synapse.

28 reaction-diffusion process in an established immunological synapse.

29 cruited to the central region (cSMAC) of the immunological synapse.

30 s in the rapid displacement of CD28 from the immunological synapse.

31 istal pole to an existing or a newly forming immunological synapse.

32 cific T lymphocytes at a junction termed the immunological synapse.

33 cell receptor/antigen complexes known as an immunological synapse.

34 tin filaments and signaling molecules at the immunological synapse.

35 t result are collectively referred to as the immunological synapse.

36 ith TCR/CD3 microcluster localization at the immunological synapse.

37 and the formation of LAT nanoclusters at the immunological synapse.

38 ing receptor turnover and maintenance of the immunological synapse.

39 g as well as more efficient formation of the immunological synapse.

40 l forces that regulate LFA-1 activity at the immunological synapse.

41 ake is shaped locally by the geometry of the immunological synapse.

42 keleton regulates receptor activation at the immunological synapse.

43 gen 1 (LFA-1) form a concentric array at the immunological synapse.

44 of cytotoxic substances from granules at the immunological synapse.

45 g domain and thus no longer localizes at the immunological synapse.

46 membrane remodelling during formation of the immunological synapse.

47 istance that facilitates localization to the immunological synapse.

48 freely mobile ligands, a key feature of the immunological synapse.

49 tionality of filamentous-actin at the T cell immunological synapse.

50 ound within CD8(+) T cell lipid rafts at the immunological synapse.

51 ing the formation of KIR2DS2 ligand-specific immunological synapses.

52 n and recruitment of cytosolic organelles to immunological synapses.

53 oskeleton as well as in the formation of the immunological synapses.

54 various morphologies, including Kupfer-type immunological synapses.

55 s in the formation or composition of anergic immunological synapses.

56 longed contacts from stable junctions called immunological synapses.

57 in information transfer at both neuronal and immunological synapses.

58 ocompatibility class II+ APCs, suggestive of immunological synapses.

59 nel components to existing and newly forming immunological synapses.

60 only form polarized clusters at Kupfer-type immunological synapses.

61 nd CD45 exclusion from the signaling foci of immunological synapses.

62 ally regulates the formation and function of immunological synapses.

63 on, leading to impaired formation of NK-cell immunological synapses.

64 As previously reported in immunological synapses, a significant nonrecoverable fra

65 of the HIV envelope (Env) in the CD4 T cell immunological synapse affects synapse formation and intr

66 venting the recruitment of active Lck to the immunological synapse after TCR engagement and limiting

67 The stability of immunological synapses allows receptor-ligand interactio

68 Prior to transfer, bacteria localize to the immunological synapse, an intimate DC/T cell contact str

69 amin A and impaired the assembly of a mature immunological synapse and central co-accumulation of PKC

70 FA-1 is to enhance TCR signaling through the immunological synapse and deliver distinct signals in CD

71 the stabilization of F-actin and Vav1 at the immunological synapse and for efficient calcium response

72 ression of V3 sequestered PKC-theta from the immunological synapse and interfered with its functions.

73 lls because it initiates the assembly of the immunological synapse and mediates firm adhesion to the

74 ired for F-actin accumulation at the NK cell immunological synapse and NK cell cytotoxicity ex vivo.

75 ected secretion requires the formation of an immunological synapse and occurs stepwise with actin reo

76 amolecular activation cluster (cSMAC) of the immunological synapse and optimal TCR/costimulatory rece

77 ngagement, beginning with an overview of the immunological synapse and progressing to regulators of T

78 signaling of PD-1/PD-L complexes within the immunological synapse and provide a basis for manipulati

79 addition, GAKIN dynamically localizes to the immunological synapse and regulates the redistribution o

80 as an important functional component of the immunological synapse and reveal a crucial role for GJs

81 s evidence of the exploitation of the normal immunological synapse and T cell activation process by H

82 a is essential for the formation of a mature immunological synapse and T cell activation.

83 ew focuses on recent work characterizing the immunological synapse and the signaling pathways involve

84 okine signaling at two successive scales: in immunological synapses and in dense multicellular enviro

85 ify the requirement of RIAM for formation of immunological synapses and in resulting T cell functions

86 he formation of T cell and NK cell cytotoxic immunological synapses and in target cell killing.

87 e micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses de

88 erable fractions of interacting molecules in immunological synapses and other stable cell-bilayer jun

89 on target cells, effector T cells establish immunological synapses and secrete cytokines.

90 tes the formation of lamellipodia and normal immunological synapses and thereby enables T cell activa

91 Mitochondria accumulate at neuronal and immunological synapses and yeast bud tips and associate

92 on in narrow junctions between immune cells (immunological synapses) and global signaling throughout

93 cts with multiple signaling molecules at the immunological synapse, and characterizing these interact

94 d antigen-presenting cells, formation of the immunological synapse, and other immune cell interaction

95 This interface has become known as the immunological synapse, and this review examines some of

96 ncreasing valency by recruiting LFA-1 to the immunological synapse, and ultimately for promoting intr

97 unoregulatory molecules participating in the immunological synapse are stored in secretory lysosomes.

98 Immunological synapses are a key feature of the system i

99 or signaling and the subsequent formation of immunological synapses are active processes dependent on

100 Immunological synapses are initiated by signaling in dis

101 Immunological synapses are specialized intercellular con

102 Kupfer-type immunological synapses are thought to mediate intercellu

103 These results suggest that HIV uses the immunological synapse as a conduit not only for selectiv

104 study, we assessed the role of Tim-3 at the immunological synapse as well as its interaction with pr

105 T cell to an APC induces the formation of an immunological synapse as well as reorientation of the mi

106 not sufficient for CD28 localization to the immunological synapse, as truncation of the cytosolic ta

107 ed that surface-anchored N protein prevented immunological synapse assembly by naive CD4(+) T cells a

108 volved in the formation and signaling of the immunological synapse at the dendritic cell side.

109 Recognition of antigen leads to formation of immunological synapses at the interface between the cell

110 In this respect, formation of the immunological synapse bears striking similarities to cil

111 horylation and transient localization to the immunological synapse before movement to the DPC.

112 tem, we developed a biophysical model of the immunological synapse between a cytotoxic lymphocyte and

113 of T-cell recognition is the formation of an immunological synapse between a T cell and a cell that i

114 er-side protein density patterns in a hybrid immunological synapse between a T-cell and a supported b

115 A distinct immunological synapse between Ag-stimulated NK cells and

116 y donor DCs contributes to generation of the immunological synapse between DCs and CD4 T cells, and t

117 ow that STIM1 and Orai1 are recruited to the immunological synapse between primary human T cells and

118 rogen peroxide from the neutrophils into the immunological synapse between the neutrophils and T cell

119 east in part by structurally undermining the immunological synapse between the NK cell and its target

120 These microclusters coalesced within the immunological synapse between the NK cell and its target

121 tion of cytokines and lytic factors into the immunological synapse between the T cell and antigen-pre

122 ptor molecules that mediate formation of the immunological synapse between the target cancer cell and

123 in which this is done is by the formation of immunological synapses between cells.

124 Nef disturbs the organization of immunological synapses between infected CD4(+) T lymphoc

125 G was associated with an increased number of immunological synapses between memory CD4(+) T cells and

126 ses these clusters were found in Kupfer-type immunological synapses between T cells and infected astr

127 ent on an increased frequency of Kupfer-type immunological synapses between T cells and tumor cells.

128 synthesized perforin rapidly appears at the immunological synapse, both in association with and inde

129 to translocate around the nucleus toward the immunological synapse but is unable to dock at the plasm

130 PKC-theta) translocates to the center of the immunological synapse, but the underlying mechanism and

131 CD22 and Siglec-G are recruited to the immunological synapse by sialic acid ligands on the Ag-b

132 Although accumulation of TCRs at the immunological synapse centre correlates with T-cell func

133 extracellular microvesicles that bud at the immunological synapse centre.

134 n disrupts the NK cell's ability to organize immunological synapse components including decreases in

135 ight on signaling pathways downstream of the immunological synapse critical for T-cell activation and

136 de actin flow in lamellipodia, growth cones, immunological synapses, dendritic spines, and filopodia

137 failed to detect an increased proportion of immunological synapses displaying the characteristic Kup

138 contributes to the reverse signaling in the immunological synapse, downstream of MHCII glycoproteins

139 coalescing key signaling molecules into the immunological synapse during T cell activation, thereby

140 n in the immune system, was recruited to the immunological synapse during T cell priming as both GJs

141 endritic cells (DCs) and is recruited to the immunological synapse during T cell priming.

142 invariant chain to accumulate stably at the immunological synapse during T cell-APC interactions.

143 studies showed that KSR1 is recruited to the immunological synapse during T-cell activation and that

144 As mitochondria translocate to the immunological synapse during TCR activation, we hypothes

145 the secretory lysosomes and polarizes toward immunological synapse during the process of target cell

146 ze the in vivo structure of antigen-specific immunological synapses during an effective immune respon

147 microtubule-organizing center (MTOC) to the immunological synapse enables the directional secretion

148 act, the CTL centrosome rapidly moves to the immunological synapse, focusing microtubule-directed rel

149 ated Erk1/2 signal pathway in the context of immunological synapse for recruitment and amplification

150 s provide new insights into the mechanism of immunological synapse formation and also demonstrate how

151 ter et al. (2015) define the early events of immunological synapse formation and granule release.

152 show that UNC-45A is disposable for NK cell immunological synapse formation and lytic granules reori

153 he Unc119-regulated pathway is essential for immunological synapse formation and T cell activation.

154 odeling, and T cells exhibited dysfunctional immunological synapse formation and T-cell signaling, wh

155 nteracts with LFA-1, a critical molecule for immunological synapse formation between T cells and APCs

156 Immunological synapse formation between T cells and targ

157 tigate the biophysical mechanisms that drive immunological synapse formation in B cells by means of M

158 an important role in leukocyte trafficking, immunological synapse formation, and numerous cellular i

159 t of T cell receptor (TCR) microclusters and immunological synapse formation, but no study has integr

160 s at the ASM/T cell interface, indicative of immunological synapse formation, in association with T c

161 artment of human CD4(+) T cells, and, during immunological synapse formation, it transiently redistri

162 ng demonstrates that at the initial stage of immunological synapse formation, LZTFL1 is concentrated

163 dual receptor systems that play key roles in immunological synapse formation, shear-dependent thrombu

164 CD8(+) T cell motility, and promotes stable immunological synapse formation.

165 ies involved in TCR signaling, as well as on immunological synapse formation.

166 ment of VAV1, which are important for stable immunological synapse formation.

167 In contrast, there was a large impairment in immunological synapse formation.

168 ults showed that the HIV Env did not disrupt immunological synapse formation.

169 osome regulation during fever contributes to immunological synapse formation.

170 The immunological synapse formed between a cytotoxic T lymph

171 dent exocytosis of cytolytic granules at the immunological synapse formed between the two cells.

172 The immunological synapse formed by a T lymphocyte on the su

173 Priming of T cells takes place via an immunological synapse formed with an antigen-presenting

174 It is postulated that HIV exploits immunological synapses formed between CD4 T cells and an

175 Confocal imaging of immunological synapses formed between primary T lymphocy

176 l previous studies have looked at aspects of immunological synapses formed by anergic T cells, but it

177 heir NK cells and the F-actin content at the immunological synapses formed by their NK cells.

178 nd exclude protein kinase C (PKC)-theta from immunological synapses formed on supported lipid bilayer

179 ation of both membranes and receptors as the immunological synapse forms.

180 into the area of cellular contact to form an immunological synapse from where T cell signaling is ini

181 ion, ciliogenesis, membrane trafficking, and immunological synapse function.

182 ultiple antigen receptor microclusters by an immunological synapse has parallels to bundling of multi

183 ntigen presenting cell junction, known as an immunological synapse if symmetric and stable and as a k

184 adhesion and costimulatory molecules in the immunological synapse impact upon the overall force of t

185 ytic compartments, which are released at the immunological synapse in a differentially regulated mann

186 ring Ag presentation, CD6 is targeted to the immunological synapse in a ligand binding-dependent mann

187 -bound molecules from APCs directly from the immunological synapse in a process termed trogocytosis.

188 tion by recruiting vinculin and talin to the immunological synapse in an Arp2/3-dependent manner, the

189 trating the recruitment of LAT to the T-cell immunological synapse in data acquired by iPALM providin

190 yzed Lck and F-actin redistribution into the immunological synapse in stimulated human primary CD4(+)

191 highlights the importance of DNAM-1 and the immunological synapse in T cell-mediated antitumor immun

192 R-T cells through the selective formation of immunological synapses, in which the sCAR-T cell, switch

193 domain mutant, HS1 failed to localize to the immunological synapse, indicating that Itk serves to rec

194 so found that a single pMHC localized to the immunological synapse induced the slow formation of a lo

195 is was dependent on the formation of compact immunological synapses, interaction of the adaptor Vav1

196 tion that is similar in some respects to the immunological synapse involved in T-cell activation and

197 rane rafts and signaling proteins to form an immunological synapse is a hallmark of T cell stimulatio

198 The immunological synapse is a stable intercellular structur

199 While immune cells lack a cilium, the immunological synapse is a surrogate cilium as it utiliz

200 tribution of the beta2 integrin LFA-1 to the immunological synapse is compromised in Cav1-knockout T

201 The immunological synapse is part of the immune response, wh

202 inase C-theta (PKC-theta) recruitment to the immunological synapse is required for full Teff activati

203 The immunological synapse is the location of sustained TCR s

204 s that one of the principal functions of the immunological synapse is to facilitate cytokine secretio

205 hesis predicts that formation of Kupfer-type immunological synapses is necessary for polarized distri

206 proper accumulation of K(+) channels at the immunological synapse (IS) a signaling zone that forms b

207 ing the transient accumulation of CD4 at the immunological synapse (IS) and its significance for T ce

208 NDE1 and dynein failed to accumulate at the immunological synapse (IS) and MTOC translocation was in

209 ected secretion of cytolytic granules at the immunological synapse (IS) and requires dynamic rearrang

210 The formation of a dynamic, actin-rich immunological synapse (IS) and the polarization of cytol

211 ular contact through the establishment of an immunological synapse (IS) between the NK cell and the t

212 ion of B cell adhesion, thereby facilitating immunological synapse (IS) formation and B cell activati

213 reover, modulating CD3 ubiquitylation alters immunological synapse (IS) formation and Erk phosphoryla

214 beling was enhanced in fat-1 cells following immunological synapse (IS) formation by CD3-specific Ab

215 ells and live images of T-cell migration and immunological synapse (IS) formation revealed that funct

216 The immunological synapse (IS) formed between immune cells a

217 was recruited to the cytoplasmic side of the immunological synapse (IS) in activated T cells.

218 d the role of cytoskeleton remodeling at the immunological synapse (IS) in cytokine secretion.

219 The immunological synapse (IS) is one of the most pivotal co

220 The Treg immunological synapse (IS) recruited fourfold more Dlgh1

221 Agonist MHC-peptide complexes in the immunological synapse (IS) signal through T cell recepto

222 ficiency on NK cell activation and cytotoxic immunological synapse (IS) structure and function.

223 T cells form an immunological synapse (IS) that sustains and regulates s

224 sition their centrosome to the center of the immunological synapse (IS) to drive polarized secretion

225 proteins characterising what is known as the immunological synapse (IS) was an important discovery sh

226 city requires the formation of an actin-rich immunological synapse (IS) with a target cell and the po

227 mune homeostasis and self-tolerance, form an immunological synapse (IS) with antigen-presenting cells

228 e, we discuss the flexibility of the primary immunological synapse (IS) with respect to motility.

229 CRAC) channels and the formation of a stable immunological synapse (IS) with the antigen-presenting c

230 The immunological synapse (IS), a highly organized structure

231 to the recruitment of the centrosome to the immunological synapse (IS), a specialized cell-cell junc

232 cells (APCs) results in the formation of an immunological synapse (IS), assembly of a signaling scaf

233 omplexes is a defining characteristic of the immunological synapse (IS), but its impact on cell commu

234 antigen-presenting cells (APCs), called the immunological synapse (IS), includes receptors and signa

235 lation, PKCtheta is rapidly recruited to the immunological synapse (IS), the region of contact betwee

236 basis of membrane protein patterning in the immunological synapse (IS), which encompass membrane mec

237 l role in modulating signaling events at the immunological synapse (IS).

238 hin a specialized membrane domain termed the immunological synapse (IS).

239 l, and negatively regulates stability of the immunological synapse (IS).

240 accumulation of diacylglycerol (DAG) at the immunological synapse (IS).

241 These are collectively known as the immunological synapse (IS).

242 ace between T cells and APCs is known as the immunological synapse (IS).

243 T cell and antigen-presenting cell, i.e. the immunological synapse (IS).

244 n the antigen-presenting cells (APCs) at the immunological synapse (IS).

245 We analyzed formation of immunological synapses (IS) in self-reactive T cell clon

246 n cluster (cSMAC) have been defined in model immunological synapses (IS).

247 igible effect on actin polymerization at the immunological synapse, leading to gaps in our understand

248 gnaling, establish a molecular basis for the immunological synapse localization of PKC-theta and indi

249 in V3 required for association with CD28 and immunological synapse localization.

250 Centrosome reorientation to the immunological synapse maintains the specificity of T-cel

251 naling plays a role in CTL function, and the immunological synapse may represent a modified cilium.

252 amolecular activation cluster (pSMAC) of the immunological synapse mediate formation of a tight adhes

253 ssary and sufficient for localization to the immunological synapse mediated by association with the c

254 PKCtheta distribution at the immunological synapse mirrors the distribution of tyrosi

255 mic instability of mitotic microtubules, the immunological synapse, neutrophil motility in a 3D matri

256 ficient to stimulate the formation of the NK immunological synapse (NKIS), with recruitment of NKG2D

257 an NK cells, UNC-45A localize at the NK cell immunological synapse of activated NK cells and is part

258 OGT) isoforms and accumulation of OGT at the immunological synapse of murine T cells.

259 mplicated in centrosome reorientation to the immunological synapse of T lymphocytes.

260 e addition of zinc, at functional inhibitory immunological synapses of NK cells with HLA-C(+) cells.

261 to super raft formation associated with the immunological synapse on colonic memory CD4+ T cells and

262 -MHC in the uropod, consistent with a motile immunological synapse or "kinapse." However, in the pres

263 We conclude that the immunological synapse orchestrates TCR sorting and relea

264 Ezrin-/- T cells exhibited normal immunological synapse organization based upon localizati

265 toxic lymphocytes showed specific defects in immunological synapse organization with these targets, r

266 MHC complexes relative to the highly dynamic immunological synapse periphery.

267 e, we have gained an appreciation of how the immunological synapse provides directionality and contex

268 e (PIP2) and that alterations in PIP2 at the immunological synapse regulate cortical actin in CTLs, p

269 ll receptor (TCR) signal transduction at the immunological synapse remains poorly understood.

270 r (TCR)-induced translocation of SLAT to the immunological synapse required Lck-mediated phosphorylat

271 that CD28 recruitment and persistence at the immunological synapse requires TCR signals and CD80 enga

272 Although cytotoxic immunological synapses restrict killing to antigenic tar

273 ligands, B cell Siglecs are recruited to the immunological synapse, resulting in suppression of BCR s

274 during T-cell immune surveillance and at the immunological synapse results in dynamic TCR quaternary

275 We propose that this reorganization of the immunological synapse sequesters the T cell antigen rece

276 ulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with t

277 The immunological synapse stops T-cell migration to allow a

278 hat the cell-to-cell contacts observed in an immunological synapse that involve the CD4(+) T cell and

279 ribe some of the many characteristics of the immunological synapse that make it a vital part of inter

280 ivated in vivo at steady state, forming true immunological synapses that polarized and anchored T cel

281 The role of the center of the immunological synapse (the central supramolecular activa

282 d granzymes from cytotoxic granules into the immunological synapse to destroy target cells as a criti

283 V envelope is recruited to the center of the immunological synapse together with the T cell receptor

284 ules themselves, so that TPCs migrate to the immunological synapse upon CTL activation.

285 ecular activation complex (cSMAC) within the immunological synapse upon T cell receptor (TCR) activat

286 ion of polarization of lytic granules to the immunological synapse upon target cell recognition.

287 d the distal pole complex (DPC) opposite the immunological synapse via association with the ezrin-rad

288 indispensable for THEMIS recruitment to the immunological synapse via the transmembrane adapter link

289 We found that the high aspect ratio of the immunological synapse was insufficient in this regard, a

290 Because activated ERK is localized at the immunological synapse, we investigated its role by showi

291 Building on previous studies at the T cell immunological synapse, we quantitatively assess the stru

292 induces the recruitment of PIP5Kbeta to the immunological synapse, where it regulates filamin A and

293 uitment of both LFA-1 and lipid rafts to the immunological synapse, which correlates with reduced tum

294 CD2 was identified biochemically and at the immunological synapse, which elicited CD16 signaling aft

295 recapitulates the domain organization of the immunological synapse, which is characterized by central

296 ction between T cells and APCs, known as the immunological synapse, which mediates efficient delivery

297 c F-actin architecture in the context of the immunological synapse, which then amplifies the downstre

298 of the fibrous actin meshwork at the T cell immunological synapse, whose structure has been shown to

299 h immobilized TCR ligands and formed smaller immunological synapses with APCs, likely due to defectiv

300 g, we found that anergic T cells make mature immunological synapses with characteristic central and p