ライフサイエンスコーパス: immunological tolerance

1 an antigen-specific nonresponsiveness (i.e. immunological tolerance).

2 regnancy is one of the strongest inducers of immunological tolerance.

3 mbrane protein involved in the regulation of immunological tolerance.

4 c medullary epithelial cells, which promotes immunological tolerance.

5 response and is instrumental in maintaining immunological tolerance.

6 y T cells (Tregs) in the dominant control of immunological tolerance.

7 beta cells as well as the reestablishment of immunological tolerance.

8 e secretion in DCs and macrophages to induce immunological tolerance.

9 erentially contributes to the maintenance of immunological tolerance.

10 tory DCs and TGF-beta+ macrophages to induce immunological tolerance.

11 ing alone without exogenous insult can break immunological tolerance.

12 play an important role in the maintenance of immunological tolerance.

13 sponses and to facilitate the development of immunological tolerance.

14 Treg) are instrumental in the maintenance of immunological tolerance.

15 and suggests a role for plasmacytoid DC2 in immunological tolerance.

16 ory T cells (Tregs) are a central element of immunological tolerance.

17 e in peripheral B-cell anergy, one aspect of immunological tolerance.

18 SK can be prevented by establishing specific immunological tolerance.

19 is a disorder of lymphocyte homeostasis and immunological tolerance.

20 s the others can lead to partial or complete immunological tolerance.

21 y, allograft rejection, and the induction of immunological tolerance.

22 apoptosis and may be critical for peripheral immunological tolerance.

23 tical for the development and maintenance of immunological tolerance.

24 rine retrovirus, under conditions leading to immunological tolerance.

25 onses and, therefore, uniquely necessary for immunological tolerance.

26 lls are immunosuppressive cells that support immunological tolerance.

27 d rapamycin, not the free form, could induce immunological tolerance.

28 ecific for the 2F5 epitope is constrained by immunological tolerance.

29 organs that should be targeted to reinstate immunological tolerance.

30 of B cell activation and the maintenance of immunological tolerance.

31 -27 is pivotal to safeguarding Treg-mediated immunological tolerance.

32 eported to participate in the maintenance of immunological tolerance.

33 ct roles in the scenario by which it assures immunological tolerance.

34 protein expression and may help to maintain immunological tolerance.

35 and produce IL-10 are required for systemic immunological tolerance.

36 ral role in the induction and maintenance of immunological tolerance.

37 heral tissue Ag expression to prompt central immunological tolerance.

38 responses and allowing the establishment of immunological tolerance.

39 , but also their impact on the regulation of immunological tolerance.

40 ional heterogeneity is a critical feature of immunological tolerance.

41 proposed to participate in the regulation of immunological tolerance.

42 es against pathogens and tumours, as well as immunological tolerance.

43 tor Foxp3 have a pivotal role in maintaining immunological tolerance.

44 ant role in the induction and maintenance of immunological tolerance.

45 ponse that later subsided suggested acquired immunological tolerance.

46 cells play an essential role in maintaining immunological tolerance.

47 controls B cell development, signaling, and immunological tolerance.

48 has a fundamental role in the achievement of immunological tolerance after transplantation.

49 central role of T cells in the induction of immunological tolerance against i.v. Ags has been well d

50 Hepatic induction of tissue-protective immunological tolerance against particulate antigens is

51 efore to design interventions that can break immunological tolerance and halt cancer progression, whe

52 vide an effective means of inducing longterm immunological tolerance and has been documented in a mon

53 This crosstalk is likely to affect immunological tolerance and homeostasis within the gut a

54 th mild symptoms may harm the development of immunological tolerance and impose a burden on families

55 l drugs and therapeutic vaccines to overcome immunological tolerance and induce the recovery phenotyp

56 mensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.

57 this feat is managed is key to understanding immunological tolerance and intervention in treating dis

58 as a central role in the dominant control of immunological tolerance and maintenance of immune homeos

59 esponse, occupying a key role in maintaining immunological tolerance and present an attractive therap

60 rotective immune responses while maintaining immunological tolerance and preventing autoimmunity.

61 RE) gene is crucial for establishing central immunological tolerance and preventing autoimmunity.

62 die perinatally, the roles of Bax and Bak in immunological tolerance and prevention of autoimmune dis

63 nd an ancillary role for Bax in safeguarding immunological tolerance and prevention of autoimmune dis

64 discuss how metabolic workload can modulate immunological tolerance and review the molecular mechani

65 sing the crucial contributions of RA to both immunological tolerance and the elicitation of adaptive

66 is not known whether these serpins influence immunological tolerance and the risk for autoimmune dise

67 Tim-3 induces immunological tolerance, and engagement of the Tim-3 imm

68 ective and safe treatment in LAR, increasing immunological tolerance, and reducing the clinical sympt

69 ) regulatory T cells (T(reg) cells) maintain immunological tolerance, and their deficiency results in

70 aches based on induction of antigen-specific immunological tolerance are being explored for treatment

71 t may also be important for the induction of immunological tolerance, as well as for the regulation o

72 likely depend, in part, on the induction of immunological tolerance, because the high levels of immu

73 When immunological tolerance breaks down, autoimmune destruct

74 ells) are critically involved in maintaining immunological tolerance, but this potent suppression mus

75 opoietic chimerism results in donor-specific immunological tolerance by apoptosis-mediated deletion o

76 cting (Bcl2-interacting) mediator, maintains immunological tolerance by deleting autoreactive lymphoc

77 The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic e

78 Induction of immunological tolerance by MBP(89-101) therefore inactiv

79 ive regulator of mucosal immunity, promoting immunological tolerance by preventing excessive T cell r

80 Aire impacts immunological tolerance by regulating the expression of

81 tocols constitute important tools to achieve immunological tolerance by Treg vaccination.

82 vity, independent of their predicted role in immunological tolerance, by regulating tissue remodeling

83 Thus, immunological tolerance can be achieved by direct modula

84 Immunological tolerance can be mediated by anergy, in wh

85 ates and HIV-1 provides direct evidence that immunological tolerance can impair humoral responses to

86 paucity of T(R) cells and a fatal breach in immunological tolerance, causing highly aggressive multi

87 eg cells develop and how they participate in immunological tolerance, contrasting, when possible, iTr

88 he role of hepatitis B e-antigen in creating immunological tolerance during hepatitis B virus infecti

89 which argues against a failure to establish immunological tolerance during implantation.

90 The establishment and maintenance of immunological tolerance entails both central and periphe

91 To analyze efficacy and better understand immunological tolerance, escape mechanisms, and side eff

92 resents an important mechanism of peripheral immunological tolerance for mature autoreactive B cells

93 Immunological tolerance guards against spurious immune r

94 critically important for the maintenance of immunological tolerance, immune homeostasis, and prevent

95 ow 60 years since the first demonstration of immunological tolerance in animal models of transplantat

96 both natural and therapeutic acquisition of immunological tolerance in childhood will provide insigh

97 of autoantigen genes in the thymus, driving immunological tolerance in maturing T cells.

98 lling and is required for the maintenance of immunological tolerance in mice.

99 have been used in vivo to induce Ag-specific immunological tolerance in Th1 responses, including tiss

100 f inhibitory signaling in the maintenance of immunological tolerance in the B lineage.

101 Induction of immunological tolerance in utero has potential applicati

102 Importantly, experimentally breaching immunological tolerance in wild-type mice also leads to

103 onditioning regimen (NMCR) aimed at inducing immunological tolerance, including splenectomy, whole bo

104 eral lymphocytes-a new approach to translate immunological tolerance into clinically applicable proto

105 The concept of immunological tolerance is central to our understanding

106 Immunological tolerance is constantly being maintained i

107 Immunological tolerance is crucial to avoid autoimmune a

108 ft is stably accepted, rejected, or achieves immunological tolerance is dependent on the frequency an

109 tion apply as to non-tolerant hosts and that immunological tolerance is permanently lost.

110 o far described that achieves organ-specific immunological tolerance is that which controls periphera

111 Achievement of immunological tolerance (long-term antigen unresponsiven

112 46a in Treg cells resulted in a breakdown of immunological tolerance manifested in fatal IFNgamma-dep

113 are potentially useful in immunotherapy, but immunological tolerance may block their function.

114 s for self-antigens and it has been proposed immunological tolerance may present a barrier to their p

115 hough common genetic pathways affect general immunological tolerance mechanisms in autoimmunity, the

116 t that intranasal exposure to Ags results in immunological tolerance mediated by functionally impaire

117 Maternal immunological tolerance of the semiallogeneic fetus invo

118 results have implications for mechanisms of immunological tolerance operating in chronic HBV infecti

119 Aire is an important regulator of immunological tolerance, operating in a minute subset of

120 sponse may open the way for the induction of immunological tolerance (or unresponsiveness in the abse

121 recipient strains), resulting in "classical" immunological tolerance, or by bone marrow infusion to s

122 abetes involves a number of steps: defective immunological tolerance, priming of anti-islet autoimmun

123 The liver is known to favor the induction of immunological tolerance rather than immunity.

124 Autoantigen-specific immunological tolerance represents a central objective f

125 The maintenance of immunological tolerance requires the deletion of self-re

126 e a better therapeutic strategy for inducing immunological tolerance than blocking the ligands for bo

127 New approaches to induce antigen-specific immunological tolerance that control both cellular and h

128 It is the loss of immunological tolerance that leads to autoimmunity.

129 ogy of these cells, including maintenance of immunological tolerance to "self" and regulation of immu

130 y approaches may facilitate the induction of immunological tolerance to a donor organ or protect it l

131 the lungs for many weeks, does not result in immunological tolerance to a yeast challenge in adult mi

132 Systemic immunological tolerance to Ag encountered in the eye res

133 ions that the microbiota plays in regulating immunological tolerance to allergen exposure outside the

134 e rapamycin, are capable of inducing durable immunological tolerance to co-administered proteins that

135 nditioned) recipients can produce a state of immunological tolerance to donor and host.

136 epatitis (AIH) is characterized by a loss of immunological tolerance to hepatocytes.

137 show that anti-TNF-alpha-treated mice showed immunological tolerance to islet cell proteins.

138 utoimmune hepatitis and attempted to restore immunological tolerance to liver autoantigens.

139 transforming rat proto-oncogene, demonstrate immunological tolerance to neu that is similar to what i

140 Attempts to achieve immunological tolerance to porcine tissues in nonhuman p

141 Although immunological tolerance to self Ags represents an import

142 dentifies T(reg) cells as vital mediators of immunological tolerance to self and Foxp3 as the mediato

143 ity against pathogens as well as maintaining immunological tolerance to self antigens.

144 B cells, is important in the maintenance of immunological tolerance to self-Ags.

145 utoreactive anergic B cell as an enforcer of immunological tolerance to self-Ags.

146 ated disease that is associated with loss of immunological tolerance to self-antigens.

147 f T cells that are essential for maintaining immunological tolerance to self.

148 To understand the mechanisms involved in immunological tolerance to skin-associated antigens, we

149 roclimate is critical for maternal and fetal immunological tolerance to sustain viable pregnancy, but

150 mbats autoimmunity or allergy by reinstating immunological tolerance to target antigens without compr

151 We examined, therefore, whether induction of immunological tolerance to the adhesion molecule that is

152 on their normal tissues do, in fact, exhibit immunological tolerance to the Ag, recapitulating the co

153 t tumors can be hindered by the induction of immunological tolerance to the target Ag as a result of

154 ed research in high school, experimenting on immunological tolerance to transplantation antigens.

155 to investigate the mechanisms that regulate immunological tolerance to tumor antigens and will facil

156 In an attempt to establish immunological tolerance toward GAD65 in NOD mice, and th

157 The liver is essential for inducing immunological tolerance toward harmless antigens to main

158 gp41-specific BnAb, 2F5, to demonstrate that immunological tolerance triggered by self-reactivity of

159 Lastly, peripheral signs of altered immunological tolerance unfold in mutant mice and in imm

160 The achievement of immunological tolerance using helminth-derived products

161 Donor-specific immunological tolerance using high doses of bone marrow

162 ation is also critical to the development of immunological tolerance via both deletional and regulato

163 cells play an essential role in maintaining immunological tolerance via their suppressive function o

164 atitis B surface antigen, indicating that no immunological tolerance was induced by prior fetal immun

165 s important for induction and maintenance of immunological tolerance, we engineered two retroviral co

166 rough BDCA2 is an effective method to induce immunological tolerance, which may be useful for treatin

167 ro with Ag/CTB conjugate induced Ag-specific immunological tolerance, which was further enhanced by a

168 early young adulthood, while an increase in immunological tolerance with aging suppresses disease on

169 rom a resistant strain coexist in a state of immunological tolerance with cells from a susceptible st

170 pressive macrophages as crucial mediators of immunological tolerance with the concomitant therapeutic

171 tory (Treg) cells have a fundamental role in immunological tolerance, with transcriptional and functi