ライフサイエンスコーパス: immunopathology

1 ion, and its inhibition leads to exaggerated immunopathology.

2 in joint-associated tissues, which prevented immunopathology.

3 response resulted in CD4(+)-T-cell-dependent immunopathology.

4 cts against development of lung eosinophilic immunopathology.

5 y, these cells mediated little virus-induced immunopathology.

6 may be useful for inhibiting immune complex immunopathology.

7 t play distinct roles in immunity as well as immunopathology.

8 gens, or arthritogenic peptides, might drive immunopathology.

9 efense is elicited through processes such as immunopathology.

10 olled, hyperactive CD8(+) T cells to prevent immunopathology.

11 tribute to the promotion of viral spread and immunopathology.

12 CM) to study the roles of IRGM1 and IRGM3 in immunopathology.

13 hanisms might protect against immune complex immunopathology.

14 mune activation may also contribute to fetal immunopathology.

15 d its expansion could control virus-mediated immunopathology.

16 ay be needed to fully suppress Th17-mediated immunopathology.

17 cerbate rather than prevent coronavirus lung immunopathology.

18 environment are not required for this severe immunopathology.

19 Ngamma-producing former TH17 cells and fatal immunopathology.

20 ts contributes to limiting T. gondii-induced immunopathology.

21 s are important for our understanding of HIV immunopathology.

22 t M. tuberculosis by preventing PMN-mediated immunopathology.

23 ntiviral immune responses can trigger lethal immunopathology.

24 gainst inappropriate CTL differentiation and immunopathology.

25 touch within hours to protect the host from immunopathology.

26 responses to CNS viral infections that limit immunopathology.

27 differentiation in hypoxia, which can limit immunopathology.

28 D-mannose may have clinical applications for immunopathology.

29 al infection, thereby contributing to airway immunopathology.

30 une responses while reducing T cell-mediated immunopathology.

31 ion responsible for exacerbating asthma-like immunopathology.

32 ential for confronting infection but causing immunopathology.

33 e Bcr1 pathways in contributing to vaginitis immunopathology.

34 cterial clearance, but failed to reduce lung immunopathology.

35 the antiviral immune response and constrain immunopathology.

36 Paneth cell death, dysbiosis and intestinal immunopathology.

37 he driving stimulus for hemophagocytosis and immunopathology.

38 e, lung cellular and cytokine responses, and immunopathology.

39 ccumulated T(FH) cells and developed a fatal immunopathology.

40 P. berghei to A. gambiae without triggering immunopathology.

41 burden, although it moderately improved lung immunopathology.

42 s can modulate P. aeruginosa-induced corneal immunopathology.

43 immune defense mechanisms that are linked to immunopathology.

44 re protected with lower bacterial burden and immunopathology.

45 e balanced by regulatory networks that limit immunopathology.

46 -1 must be balanced with the need to prevent immunopathology.

47 flammasome activation can also contribute to immunopathology.

48 may safely suppress other FcgammaR-dependent immunopathology.

49 t clinical outcome, bacterial loads, or lung immunopathology.

50 e 13 infection increased CD8 T cell-mediated immunopathology.

51 roaches to overcome glucocorticoid-resistant immunopathology.

52 role in mediating H. pylori-related gastric immunopathology.

53 target pathogens, but cell death results in immunopathology.

54 MICA, which could contribute to the vascular immunopathology.

55 oth immune-mediated virus elimination and of immunopathology.

56 point perpetuates a destructive response and immunopathology.

57 to functions of this transcription factor in immunopathology.

58 ntial for preventing excessive T cell-driven immunopathology.

59 ould also lead to increased inflammation and immunopathology.

60 parasite clearance as well as to acute-stage immunopathology.

61 ss allergens and, in this way, contribute to immunopathology.

62 ion of inflammatory monocytes that triggered immunopathology.

63 type I IFN signaling and diminution of lung immunopathology.

64 orate organ damage in the setting of sterile immunopathology.

65 onses yet avoid inappropriate activation and immunopathology.

66 ote efficient viral clearance while limiting immunopathology.

67 ontributing to this process while preventing immunopathology.

68 robiota, activation of immune responses, and immunopathology.

69 ng NETs with DNase protects mice from type-2 immunopathology.

70 for viral clearance, they also contribute to immunopathology.

71 ing a novel strategy of host protection from immunopathology.

72 L-27, regulate ILC2 cells to restrict type 2 immunopathology.

73 sponsive to antigenic stimulation to prevent immunopathology.

74 sociated with a failure to resolve pulmonary immunopathology.

75 liver, where they can regulate immunity and immunopathology.

76 with host immunity, but the other can cause immunopathology.

77 ost defence and tissue repair but can induce immunopathology.

78 clinical implications for local immunity and immunopathology.

79 tic cells to reduce M. tuberculosis-elicited immunopathology.

80 st a potential role in both host defence and immunopathology.

81 further implicating SHP2 in lupus-associated immunopathology.

82 also associated with reductions in pulmonary immunopathology.

83 ate into Foxp3(+) Treg cells that suppressed immunopathology.

84 rs of modern immunology and a pathfinder for immunopathology.

85 ponses that may result in host defense or in immunopathology.

86 , but early IFN-I administration ameliorates immunopathology.

87 d protects the cerebellum from infection and immunopathology.

88 (ILC2 cells) and infection-associated type 2 immunopathology.

89 have been implicated in both protection and immunopathology.

90 sing increased susceptibility to RSV-induced immunopathology.

91 attractive therapeutic target in a range of immunopathologies.

92 sponses including factors that contribute to immunopathologies.

93 lso associated with the development of human immunopathologies.

94 ne interventions (including vaccination) and immunopathologies.

95 ent of protective immunity, but also mediate immunopathologies.

96 lting in chronic inflammatory and autoimmune immunopathologies.

97 First, the recognition that host immunopathology affects lesional TB drug distribution me

98 d indeed increase the risk of developing HLH immunopathology after lymphocytic choriomeningitis virus

99 imuli but whose overactivation can result in immunopathologies and sometimes even death.

100 damental role in balancing viral control and immunopathology and also functions to regulate T cell re

101 ls (Tregs) play a key role in HIV-associated immunopathology and are susceptible to maraviroc-mediate

102 vation are necessary for induction of type 2 immunopathology and aspirin sensitivity.

103 itation of signaling is essential to prevent immunopathology and autoimmune disease.

104 d, on the other, the requirement to minimize immunopathology and autoimmunity.

105 inth infection, both by controlling damaging immunopathology and by inhibiting protective immunity.

106 , NZM.Taci-/-, and NZM.Br3-/- mice had renal immunopathology and clinical disease that were at least

107 In murine schistosomiasis, immunopathology and cytokine production in response to p

108 wever, excess inflammation may contribute to immunopathology and disease progression (e.g. inflammati

109 se cytokines can contribute to host-mediated immunopathology and disease progression.

110 rprisingly, IFNgamma-knockout mice developed immunopathology and hemophagocytosis comparable to that

111 in the GR(lck-Cre) mice was associated with immunopathology and hyperactive Th1 cell function as rev

112 However, its role in cancer immunopathology and immunotherapy is poorly understood.

113 le Treg activity results in autoimmunity and immunopathology and impairs the quality of pathogen-spec

114 ethasone therapy improved ampicillin-induced immunopathology and improved outcomes in mice with sever

115 In allergic lung disease models, immunopathology and local Th2 and ILC2 accumulation is r

116 , and we recently showed that IL-17 mediates immunopathology and lung injury after influenza infectio

117 ted mice exhibited protection against ocular immunopathology and maintained corneal mechanosensory fu

118 sts hypercytokinemia is the driving cause of immunopathology and morbidity/mortality in hyperinflamma

119 AV) is frequently characterized by extensive immunopathology and proinflammatory signaling that can p

120 generating a testable 'metapathway' model of immunopathology and providing new insights for treatment

121 nses is a potential strategy for controlling immunopathology and related diseases.

122 , genetic depletion of IRAK-M did not affect immunopathology and renal dysfunction during early posti

123 ore the development of clinical symptoms and immunopathology and reveal a role for soluble TNF in med

124 of the factors that influence HIV-1-induced immunopathology and subsequent CD4(+) T-cell decline is

125 iosis, because it mediates ehrlichia-induced immunopathology and supports bacterial replication, perh

126 ncreased viral load; however, the heightened immunopathology and susceptibility to subsequent asthma

127 lls, which restricts C. difficile-associated immunopathology and the accumulation of IFN-gamma-expres

128 Very recent experimental data about the immunopathology and the determinants of autoantibody for

129 miology, clinical and neuroimaging features, immunopathology and therapy of NMO and NMO spectrum diso

130 ng CD8(+) T cells, which is known to mediate immunopathology and toxic shock in a murine model of fat

131 ws that greater immunity could predispose to immunopathology and transmission at the lung apex.

132 ling that shape the delicate balance between immunopathology and viral clearance.

133 is hypothesized to arise because of greater immunopathology and/or autoimmunity.

134 responses to promote viral clearance, limit immunopathology, and enhance survival.

135 H17-like phenotype in Aspergillus-associated immunopathology, and identifies key players, i.e. TLR2 a

136 system by preventing autoimmunity, limiting immunopathology, and maintaining immune homeostasis.

137 volves early Toll-like receptor (TLR)-driven immunopathology, and resolution of inflammation is neede

138 influencing multiple facets of HIV-1-related immunopathology, and that a greater focus on this parame

139 into the regulation of hepatic injury, liver immunopathology, and transplant tolerance.

140 demonstrate that reductions in pulmonary TB immunopathology are dependent on hematopoietic VitD resp

141 Bacterial superinfection and associated lung immunopathology are major contributors to hospitalizatio

142 Both host defense and immunopathology are shaped by the ordered recruitment of

143 Highlighting immunopathology as a death cause, infected animals are r

144 RSV-associated illness is in part caused by immunopathology associated with a robust type 2 response

145 Antibiotic-induced immunopathology associated with bacterial cell wall lysi

146 -10 overproduction substantially reduced the immunopathology associated with GVHD.

147 ectin-1 contributes to lung inflammation and immunopathology associated with persistent fungal exposu

148 cific pathogens while minimizing the risk of immunopathology at steady state.

149 MPhis; differential suppression facilitating immunopathology at the expense of immunity.

150 estrained IL-17 signaling is associated with immunopathology, autoimmune disease, and cancer progress

151 R229Q) microbiota further contributed to the immunopathology because its transplant into WT recipient

152 Lung TCD8 impairment may prevent immunopathology but also contributes to recurrent lung i

153 he JAK1/2 not only prevents the onset of HLH immunopathology but also is effective against existing H

154 gen conditions adaptive immune responses and immunopathologies, but we know little about its variatio

155 cA during MRSA skin infection contributes to immunopathology by altering peptidoglycan structure.

156 enzyme-linked immunosorbent assay; for renal immunopathology by immunofluorescence and histopathology

157 kotrienes (cysLTs) facilitate mucosal type 2 immunopathology by incompletely understood mechanisms.

158 ling in protection against virally triggered immunopathology by negatively regulating activation of t

159 factor beta (TGF-beta), Breg cells suppress immunopathology by prohibiting the expansion of pathogen

160 ect evidence of modulation of gluten-induced immunopathology by the microbiota.

161 tonomously suppress their responses to limit immunopathology by upregulating inhibitory receptors suc

162 Protection against eosinophilic immunopathology by vaccines containing delta inulin adju

163 suggest that control of infection-associated immunopathology can be based on a unified defense operat

164 energy and protein, and the damage caused by immunopathology can sometimes outweigh the protective be

165 ked improvement of clinical outcome and lung immunopathology caused by bacterial superinfection requi

166 to control pulmonary fungal replication and immunopathology caused by induced type 2 Th2 cell respon

167 eptors and their activating lipid ligands in immunopathologies combined with complementary and focuse

168 d mononuclear cells, and extensive pulmonary immunopathology compared with wild-type (WT)-->WT chimer

169 r clinical outcome, bacterial infection, and immunopathology, despite its moderate reducing effects o

170 terns nor the impact of Il10 on LCMV-induced immunopathology differed conspicuously between these two

171 The mechanisms protecting from immunopathology during acute bacterial infections are in

172 r that plays a crucial role in limiting host immunopathology during bacterial infections by controlli

173 egulator of HIFs, led to lethal CTL-mediated immunopathology during chronic infection, and VHL-defici

174 aintenance of the Th17 cell lineage, but not immunopathology during experimental autoimmune encephalo

175 nterplay between host antiviral immunity and immunopathology during hepatitis E virus (HEV) infection

176 ion of neutrophils to protective immunity or immunopathology during infection with monocytic Ehrlichi

177 IFN-gamma) drives antiparasite responses and immunopathology during infection with Plasmodium species

178 ially protects against severe egg-associated immunopathology during infection, while allowing worm-an

179 flammation at mucosal surfaces, and regulate immunopathology during infectious responses.

180 ding which of these cell types contribute to immunopathology during inflammatory diseases.

181 ggest that Tim3 could be targeted to prevent immunopathology during influenza infection and demonstra

182 sine receptor A(2A) were more susceptible to immunopathology during intraperitoneal infection with T.

183 showed reduced viral clearance and enhanced immunopathology during LCMV infection.

184 a mutant could restore the capacity to cause immunopathology during murine vaginitis to this avirulen

185 cterial replication indirectly and promoting immunopathology during severe infection with an intracel

186 l that increases inflammasome activation and immunopathology during skin infection.

187 acteristics of effector T-cell responses and immunopathology during subsequent heterologous infection

188 est an association between this cytokine and immunopathology during tuberculosis-IRIS.

189 t in vivo and contributes to protection from immunopathology during viral clearance.

190 ever, the in vivo inflammatory responses and immunopathology elicited by acute challenge with the sta

191 with MCMV (LCMV+MCMV), they had more severe immunopathology, enhanced viral burden in multiple organ

192 e history of LCMV infection intensifies MCMV immunopathology, enhances MCMV burden in multiple organs

193 lpha or solTNF-alpha in regulating pulmonary immunopathology following influenza infection are unclea

194 The severity of immunopathology from non-infectious inflammation is main

195 In pulmonary tuberculosis, MMP-driven immunopathology generates matrix degradation products.

196 of NK-cell cytotoxicity in limiting HLH-like immunopathology, highlighting the important role of NK c

197 promotes Th1 and Th17 responses and gastric immunopathology, IL-18 is required for Treg differentiat

198 GM-CSF rather than IL-17 induces spontaneous immunopathology in a mouse model of CNS inflammation.

199 for programming of CD8(+) T cells to mediate immunopathology in a self-tissue.

200 3 elicits antifungal resistance with limited immunopathology in A. fumigatus infection.

201 with A/WSN/33 causes significant disease and immunopathology in C57BL/6 mice but not in B6.Cg-Kit(W-s

202 While T cells-mediated immunopathology in CHIKV infections has been reported, t

203 it is possible that DNA traps contribute to immunopathology in chronic inflammatory diseases, such a

204 Protection against gluten-induced immunopathology in clean SPF mice was reversed after sup

205 a expansion, further enhanced gluten-induced immunopathology in conventional SPF mice.

206 ed interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), how

207 rant state was found to protect mice against immunopathology in Gram-negative and Gram-positive infec

208 arginase-expressing gMDSCs to regulate liver immunopathology in HBV infection.

209 the development of Th17 cell-mediated severe immunopathology in helminthic disease.

210 MAPCs to control T cell responses that drive immunopathology in human autoimmune disease and allograf

211 The increased immunopathology in infected IDO1-knockout mice was assoc

212 ively and negatively modulate gluten-induced immunopathology in mice.

213 by drinking-water supplementation suppressed immunopathology in mouse models of autoimmune diabetes a

214 litis (EAE) is a valuable model for studying immunopathology in multiple sclerosis (MS) and for explo

215 hown to confer protection as well as promote immunopathology in mycoplasma disease.

216 y attenuated for bacterial burden as well as immunopathology in NHPs.

217 ay in the perpetuation of IL-12/Th1-mediated immunopathology in PBC.

218 e potent regulators of antiviral T cells and immunopathology in persistent viral infection.

219 This increase results in exacerbating immunopathology in select organs, ranging from transient

220 However, the severity of immunopathology in the context of alloimmune diseases su

221 s-host interactions take place, resulting in immunopathology in the form of inflammation, immune acti

222 or cells (MDSCs) to suppress T cell-mediated immunopathology in this setting.

223 in vitro and is associated with significant immunopathology in vivo, FIV-C36 (referred to here as hi

224 multiple sclerosis and causes characteristic immunopathology in which central nervous system (CNS) de

225 avoid excessive inflammation and consequent immunopathology, including the anti-inflammatory cytokin

226 Lymphoid tissue immunopathology is a characteristic feature of chronic H

227 The extent to which intestinal immunopathology is caused by insufficient Roquin express

228 le of TCD8 impairment in viral clearance and immunopathology is unclear.

229 antimycobacterial mediator that ameliorates immunopathology, is measurable in exhaled breath in indi

230 but persistent MAVS signalling leads to host immunopathology; it remains unknown how these signalling

231 truction is an initial event in tuberculosis immunopathology, leading to caseous necrosis and comprom

232 was not observed, and this absence of severe immunopathology may have contributed to the recovery and

233 egation is important for innate immunity and immunopathology mediated by eosinophils and clarify how

234 nization but failed to induce robust vaginal immunopathology (neutrophil recruitment, interleukin-1be

235 uction of IL-1beta, which contributes to the immunopathology observed in cutaneous leishmaniasis pati

236 ull life cycle and recapitulates some of the immunopathology observed in patients with chronic infect

237 of IL-23 in TLR9(-/-) mice recapitulated the immunopathology observed in WT mice.

238 Extensive immunopathology occurs in human immunodeficiency virus (

239 The immunopathology of ABPA, ABPM, and SAFS is incompletely

240 be used to further our understanding of the immunopathology of bovine tuberculosis and to produce mo

241 Bacterial burden and pulmonary immunopathology of chimeric mice lacking TLR2 in the hem

242 h in protection and in the cytokine-mediated immunopathology of dengue, how the balance is maintained

243 The diverse immunopathology of granulomas and cavities generates a p

244 w SHIVC109F.PB4-derived viruses to study the immunopathology of HIV-1 clade C infection and to evalua

245 ing a useful generic model to understand the immunopathology of human PBC.

246 (IM), as a fatal illness that magnifies the immunopathology of IM in boys with the X-linked lymphopr

247 IL-10 and its homologs may contribute to the immunopathology of IRIS in these patients.

248 examine new paradigms for understanding the immunopathology of MS, present recent data defining the

249 her, these findings provide insight into the immunopathology of neuropsychiatric complications that a

250 The role of the macrophage in the immunopathology of periodontitis has not been well defin

251 activation molecule directly related to the immunopathology of the disease and is a potential clinic

252 against infection and may contribute to the immunopathology of the disease.

253 nd cytokine production, resulting in altered immunopathology of the lungs compared to A2AP-deficient

254 ion are discussed in relation to the complex immunopathology of this condition.

255 The end-stage immunopathology of type 1 diabetes resulting in beta-cel

256 elopment of a memory response nor exacerbate immunopathology of vaccinated mice over at least a 4-mon

257 studies to address mechanisms underlying the immunopathology of VZV-associated posterior uveitis.

258 th significantly increased lung eosinophilic immunopathology on day 6 postchallenge, this was not see

259 , nor its progeny, is solely responsible for immunopathology or autoimmunity.

260 ts including cross-reactive antiviral T cell immunopathology, or a combination of both remains undete

261 erleukin-4 (IL-4) responses, suggesting that immunopathology predominantly reflects an inadequate vac

262 to intrarenal complement activation as renal immunopathology progresses.

263 quence was to better describe and manipulate immunopathology relevant to disease.

264 al cell that is responsible for driving full immunopathology remains unidentified.

265 ysiological contributions of SAPs to vaginal immunopathology require hypha formation, other hypha-ass

266 Immunopathology required antigen-specific CD4 T cells an

267 ntion strategies directed against Th2-driven immunopathologies such as allergies.

268 t their relative contribution in controlling immunopathology, such as colitis and other untoward infl

269 ted CD73(-/-) mice against T. gondii-induced immunopathology, suggesting that the absence of CD73-gen

270 icated in regulation of polymerase activity, immunopathology, susceptibility to secondary bacterial i

271 lammation, epithelial regeneration, and lung immunopathology that are dysregulated during influenza v

272 pe 2 immunity and subsequent Th2-biased lung immunopathology that facilitates C. neoformans growth an

273 ld play an important role in the detrimental immunopathology that is seen in aspergillosis.

274 c NET overflow is a novel viral mechanism of immunopathology that may be responsible for characterist

275 nd macrophages are targets of HIV-1-mediated immunopathology, the impact of high viremia on activatio

276 med with new criteria for defining vaginitis immunopathology, the purpose of this study was to determ

277 T cells, particularly Th1 cells, in corneal immunopathology, the relative contribution of recently d

278 in limiting CNS autoimmunity and preventing immunopathology, these data define a detrimental role of

279 ugh to escape eradication but elicits enough immunopathology to ensure its transmission.

280 t host stresses while the pathogen waits for immunopathology to promote its transmission.

281 in and inflammation of the joints, a similar immunopathology to rheumatoid arthritis.

282 lation of LDHA in T cells protects mice from immunopathology triggered by excessive IFN-gamma express

283 Additionally, gastric immunopathology was accelerated in Helicobacter pylori-i

284 dose challenge with LCMV clone 13, increased immunopathology was associated with a reduced number of

285 ponses, during challenge with PICV increased immunopathology was directly associated with these cross

286 e alleviating effect of Il10 on LCMV-induced immunopathology was found to be operative in delayed-typ

287 Furthermore, LPDA1-derived immunopathology was independent of neutrophil infection

288 cell response and its role in protection and immunopathology, we characterized the plasmablast respon

289 whether SHP2 alters autoimmunity and related immunopathology, we treated MRL/lpr mice with an SHP2 in

290 Clinical features and airway immunopathology were assessed.

291 protein 2, and severe lung neutrophilia and immunopathology were linked to the poor clinical outcome

292 Viral clearance and associated immunopathology were measured after infection of WASP-de

293 t both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived in

294 they have decreased protection and enhanced immunopathology when reexposed to one of the two viruses

295 ates of parasite replication and reduced gut immunopathology, whereas wild-type (WT) mice experienced

296 treatment of MRSA skin infection exacerbates immunopathology, which is IL-1 dependent.

297 unctions may serve to reduce T cell-mediated immunopathology while still allowing for effective antiv

298 ses characterized by HBV replication without immunopathology, whilst L-arginine decreased.

299 orchestrates inflammatory responses and lung immunopathology with diminished survival.

300 ign of novel therapeutic options to minimize immunopathology without impairing beneficial host defens