ライフサイエンスコーパス: immunophilin

1 otein has been identified and shown to be an immunophilin.

2 ggesting a cytoskeletal localization for the immunophilin.

3 tide repeat (TPR) domain protein, such as an immunophilin.

4 B transporters and the TWISTED DWARF1 (TWD1) immunophilin.

5 -binding proteins form the FKBP subfamily of immunophilins.

6 ved family of intracellular receptors called immunophilins.

7 in similar to the heat-shock protein-binding immunophilins.

8 o the FK-506 binding protein (FKBP) class of immunophilins.

9 pathways independent of calcineurin and the immunophilins.

10 d hormones, and on small molecules that bind immunophilins.

11 NA synthesis and in steroid receptor-binding immunophilins.

12 p23, and one of three high molecular weight immunophilins.

13 is inhibited by dominant factors related to immunophilins.

14 -modified channels and channels deficient in immunophilin 12-kDa FK506-binding protein.

15 A5 did not interact with the closely related immunophilins AIPL1, FKBP51, or FKBP52.

16 52 genes have been found to encode putative immunophilins, among which 23 are putative FKBPs and 29

17 Cyclophilin D (CypD) is a mitochondrial immunophilin and a key positive regulator of the mitocho

18 The expression of many immunophilin and parvulin genes is ubiquitous except for

19 ne-regulated FK506-binding protein 5 (FKBP5) immunophilin and small Ras family G protein cell growth

20 FKBP46 belongs to the high-molecular-weight immunophilins and shares many characteristic features wi

21 ential interactions between Hsp90-associated immunophilins and target proteins such as steroid recept

22 In addition, immunophilins and their chemical ligands are providing u

23 Immunophilins and XAP2 associated with these complexes b

24 ltiprotein complex containing hsp90, p23, an immunophilin, and often some hsp70.

25 iprotein complexes containing hsp90, p23, an immunophilin, and often some hsp70.

26 molecular chaperone components, including an immunophilin, and p23.

27 risk recipients, avoid immediate exposure to immunophilin antagonists, and perform biopsy frequently

28 Competition assays demonstrated that both immunophilins antagonize one another, and binding assays

29 ast, the high molecular weight hsp90-binding immunophilins appear to play a role in protein trafficki

30 Plant immunophilins are a broadly conserved family of proteins

31 Immunophilins are a family of conserved proteins found i

32 Immunophilins are components of many steroid receptor co

33 Immunophilins are defined as receptors for immunosuppres

34 Immunophilins are intracellular receptors for the immuno

35 Immunophilins are intracellular receptors of the immunos

36 We propose that immunophilins are modulators of the cortisol-HPA axis re

37 Immunophilins are protein chaperones with peptidylprolyl

38 Immunophilins are studied in both plants and animals for

39 These results suggest that immunophilins are TRPC channel accessory proteins that p

40 unosuppressant, rapamycin, binds to the same immunophilin as FK506 but inactivates a protein kinase p

41 d, tetratricopeptide repeat (TPR)-containing immunophilin, associates with nascent plasma membrane io

42 An immunophilin-based mechanism could account for the toxic

43 to identify targets of kinase inhibitors and immunophilin binders.

44 ctivity of the channels for their respective immunophilin binding partner.

45 o, nuclear movement of p53 is inhibited when immunophilin binding to dynein is competed for by expres

46 These data show that immunophilin binding to hsp90 via TPR domains is conserv

47 Sanglifehrin A belongs to a novel family of immunophilin-binding ligands.

48 ntaining hsp90, hsp70, p60, p23, and several immunophilins can assemble steroid receptors and oncogen

49 Several recent studies indicate that immunophilins can regulate neuronal survival and nerve r

50 racting protein (AIP), a survivin-associated immunophilin, causes embryonic lethality in mice by embr

51 does not express caveolin, does not form an immunophilin-caveolin complex, and does not transport ne

52 of caveolin is part of a heat-shock protein-immunophilin chaperone complex consisting of caveolin, h

53 In addition, immunophilin chaperones that form complexes with caveoli

54 The steroid-induced immunophilin cochaperone FKBP51 inhibits PR- and GR-medi

55 Deletion of Fkbp52, an immunophilin cochaperone for PR, results in uterine-spec

56 c studies in mice for a potential role of an immunophilin cochaperone in the etiology of human endome

57 on distinct from where the immunosuppressant-immunophilin complex bind.

58 hreonine phosphatase calcineurin by the drug-immunophilin complex.

59 receptor engagement and dependent upon drug-immunophilin complexes and, presumably, calcineurin acti

60 study of glucocorticoid receptor (GR).hsp90.immunophilin complexes in mammalian cells, there is cons

61 FK506.FKBP12 drug-immunophilin complexes inhibited the interaction of NFAT

62 se known to be the cellular target of ligand-immunophilin complexes, increase 3-fold during myogenesi

63 specifically inhibited by immunosuppressant immunophilin complexes, which enabled its function in re

64 ly shown that immunoadsorption of the FKBP52 immunophilin component of steroid receptor.hsp90 heteroc

65 ins suggest that the association of RelA and immunophilins could be direct.

66 omyces cerevisiae, CsA and FK506 bind to the immunophilins cyclophilin A and FKBP12 and the resulting

67 ous CrkII, but not CrkI, associates with the immunophilins, cyclophilin A, and 12-kDa FK506-binding p

68 The immunophilins, cyclophilins, catalyze peptidyl cis-trans

69 ocomplexes contain the cyclosporin A-binding immunophilin CyP-40.

70 We have shown recently that the immunophilins CyP-40 and FKBP52/hsp56 bind to a common s

71 (SQUINT) is the Arabidopsis ortholog of the immunophilin CyP40 (cyclophilin 40) and promotes microRN

72 FKBP52 and FKBP51, the cyclosporin A-binding immunophilin CyP40, and protein phosphatase PP5.

73 suggesting that transcriptionally regulated, immunophilin-dependent but calcineurin-independent targe

74 ovide strong support for the hypothesis that immunophilin dFKBP59 is part of the TRPL-INAD signaling

75 in-1 palmitoylation because agents that bind immunophilins did not inhibit palmitoylation.

76 Each of the three receptor-associated immunophilins displays interactions with progesterone re

77 How the two structurally distinct immunophilin-drug complexes bind the same target has rem

78 Genetic evidence supports a model in which immunophilin-drug complexes inhibit calcineurin to preve

79 p53.hsp90.immunophilin.dynein complexes can be formed by incubatin

80 Cyclophilin-40 (CyP40) is part of the immunophilin family and is found in Hsp90-containing pro

81 This is by far the largest immunophilin family identified in any organism.

82 gs such as cyclosporin and FK506 defines the immunophilin family of proteins, and the FK506-binding p

83 interact with cyclophilin B, a member of the immunophilin family of proteins.

84 ble explanation for why plants have a larger immunophilin family than animals.

85 e that cyclophilin A (CyPA), a member of the immunophilin family, is secreted by VSMCs in response to

86 A) an intracellular protein belonging to the immunophilin family.

87 , an agent that competes with FK-506 for the immunophilin, FK binding protein 12, does not inhibit ca

88 Rapamycin binds intracellularly to the immunophilin FK506 binding protein 12 (FKBP12), and the

89 Immunophilin FK506-binding protein 52 (FKBP52) is a coch

90 1, also called FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs).

91 (i) the identification of a homologue of the immunophilin FKBP-12 with dorsal anterior expression in

92 1046, a non-immunosuppressive ligand of the immunophilin FKBP12 (FK-506-binding protein 12 kDa), has

93 Disruption of the association between immunophilin FKBP12 and Ry1R with FK 506 or rapamycin co

94 The immunophilin FKBP12 binds the skeletal muscle Ca2+ relea

95 The immunophilin FKBP12 binds to TbetaR-I and inhibits its s

96 hese regions, creating a pocket in which the immunophilin FKBP12 can fit.

97 ransition state for folding/unfolding of the immunophilin FKBP12 has been characterised using a combi

98 ough interaction screens have shown that the immunophilin FKBP12 interacts with TGF-beta type I recep

99 The immunophilin FKBP12 is an evolutionarily conserved abund

100 The immunophilin FKBP12 is one of the most abundant and cons

101 The data presented demonstrate that the immunophilin FKBP12 is present in retina and specificall

102 ere performed on rat retinal tissue, and the immunophilin FKBP12 was found to be present in retina.

103 The immunophilin FKBP12, the phosphatase calcineurin, and Ca

104 omain of TRAF2 and TRAF6 with repeats of the immunophilin FKBP12, we demonstrate that their effector

105 cin, which inhibits mTOR in complex with the immunophilin FKBP12.

106 hydrophobic ligand-binding site in the small immunophilin FKBP12.

107 on requires binding of the antibiotic to the immunophilin FKBP12.

108 the mTOR inhibitor rapamycin to the cellular immunophilin FKBP12.

109 rotein containing regions of homology to the immunophilins FKBP12 and FKBP52.

110 A 12-kDa immunophilin (FKBP12) is an integral component of the sk

111 sive potency and in its interaction with the immunophilin, FKBP12.

112 t encodes a protein similar to the mammalian immunophilin, FKBP12.

113 n of its COOH-terminal domain (CTD) with the immunophilin FKBP13.

114 The immunophilin, FKBP20-2, belongs to the FK-506 binding pr

115 In this paper, we report on insect immunophilin FKBP46 and its associated kinase.

116 Moreover, we demonstrate that the insect immunophilin FKBP46 can be phosphorylated by human and S

117 Finally, the Sf9 nuclear immunophilin FKBP46 was identified as a death-associated

118 Over-expression of the FK506-binding immunophilin FKBP51 also causes a generalized state of g

119 ntron boundaries as the structurally related immunophilin FKBP51 gene (FKBP5).

120 Several studies suggest a role for the immunophilin FKBP51 in NF-kappaB activation, but the und

121 We recently reported that the immunophilin FKBP51 is a scaffolding protein that can en

122 cation, while knockdown of FKBP5, coding for immunophilin FKBP51, was associated with increased basel

123 Hsp90 binding immunophilins FKBP51 and FKBP52 modulate steroid recepto

124 nding of hormone-induced substitution of one immunophilin (FKBP51) for another (FKBP52), and concomit

125 ation revealed two key binding proteins, the immunophilin FKBP52 and the beta1-subunit of L-type volt

126 idence that both hsp90 and the FK506-binding immunophilin FKBP52 play a role in receptor movement fro

127 The immunophilin FKBP52 serves as a cochaperone for steroid

128 Immunophilin FKBP52 serves as a cochaperone to govern no

129 iRNA knockdown of FKBP4 gene, coding for the immunophilin FKBP52, inhibited cortisol-activated GR nuc

130 90-organizing protein Hop, the FK506-binding immunophilins FKBP52 and FKBP51, the cyclosporin A-bindi

131 om DLD-1 human colon cancer cells contain an immunophilin (FKBP52, CyP-40, or PP5) as well as dynein.

132 is now clear that the large molecular weight immunophilins, FKBP52 and FKBP51, play important regulat

133 Immunophilin FKBP59, another member of the signalplex, b

134 Given that the immunophilin FKBP65 does not exhibit LH activity, it is

135 ith a role for HSC/HSP70 similar to that for immunophilins, FKBPs and CyP40.

136 interaction between TRPC6 and the endogenous immunophilin found in HEK cells.

137 east Saccharomyces cerevisiae, the nucleolar immunophilin, Fpr3, is phosphorylated at tyrosine and de

138 g pathway in and the purification of several immunophilins from Vicia faba plants.

139 In this study, we investigated three immunophilin genes involved in the Arabidopsis thaliana

140 This immunophilin has unique spatiotemporal expression in the

141 uman FKBP12, a 12 kDa FK506-binding protein (immunophilin), has been characterised.

142 In plants, high-molecular-weight immunophilins have been shown to regulate cell divisions

143 ng support for the inositolphosphate-binding immunophilin having an apparent mass of 12 kD, and it is

144 B virus X-associated protein 2 (XAP2) is an immunophilin homolog and core component of the aryl hydr

145 nal half (amino acids 1-169), containing the immunophilin homology region, similarly reduced PDE4A5 a

146 m has been defined, and it is shown that key immunophilin (IMM) components of the trafficking machine

147 involved in the binding are common for both immunophilin-immunosuppressant complexes, a significant

148 in phosphatase, is the common target for two immunophilin-immunosuppressant complexes, cyclophilin A-

149 ar basis of regulation of CN activity by the immunophilin-immunosuppressant.

150 bility of calmodulin to stimulate binding of immunophilin/immunosuppressant to calcineurin.

151 Studies have identified immunophilins in all organisms examined including bacter

152 s study, we have surveyed the genes encoding immunophilins in Arabidopsis genome.

153 A striking feature of immunophilins in Arabidopsis is that a large fraction of

154 ther family of PPIases that are unrelated to immunophilins in protein sequences and drug binding prop

155 The physiological roles of the immunophilins in regulating steroid receptor function ha

156 of differential roles for FKBP51 and FKBP52 immunophilins in the control of steroid receptor subcell

157 peptide repeat (TPR) proteins (also known as immunophilins) in hormone-free steroid receptor complexe

158 cyclosporin A and FK506, when complexed with immunophilins, inactivate the protein phosphatase calcin

159 Immunophilins, including FK506-binding proteins (FKBPs),

160 n trapped in the endoplasmic reticulum in an immunophilin-independent pathway.

161 However, immunophilin inhibitors suppressed the ability of CrkII-

162 that the PPIase domains of the hsp90-binding immunophilins interact directly with cytoplasmic dynein

163 To evaluate TRPC-immunophilin interactions in vivo, immunoprecipitations

164 atic activity, calcineurin-immunosuppressant/immunophilin interactions, or Ca2+ binding.

165 Taken as a whole, these studies identify immunophilin interchange as the earliest known event in

166 The TWD1/FKBP42 co-chaperone immunophilin is required for exit of ABCB19 from the ER,

167 omerase activity of this membrane-associated immunophilin is strongly inhibited by nanomolar concentr

168 Nevertheless, the physiological function of immunophilins is poorly understood in any organism.

169 he RyR because, to detect the receptor-bound immunophilin, it was necessary to add FKBP12 to the puri

170 similar amounts of cyclophilin A and FKBP12, immunophilins known to be intracellular-binding targets

171 GR reporter gene assays under conditions of immunophilin ligand and dexamethasone treatment that yie

172 Furthermore, in this model, we show that the immunophilin ligand FK506 but not cyclosporin A prevents

173 de in the development of inhibitors based on immunophilin ligand polyketides, which target the TOR-me

174 Rapamycin is an immunosuppressive immunophilin ligand reported as having neurotrophic acti

175 ons also respond differentially to FK506, an immunophilin ligand with well-established neuroprotectiv

176 present report, a novel nonimmunosuppressive immunophilin ligand, GPI-1046 (3-(3-pyridyl)-1-propyl (2

177 irst step, we treated L929 cells with select immunophilin ligands [FK506, rapamycin, cyclosporin A (C

178 The immunophilin ligands are neurotrophic in intact animals.

179 We propose that these immunophilin ligands can protect neurons from Ca(2+)-ind

180 specific calcineurin inhibitor, mimicked the immunophilin ligands in its neurotrophic effect.

181 As expected, all four immunophilin ligands increased both the intracellular co

182 Although immunosuppressant immunophilin ligands promote neurite outgrowth in vitro,

183 Neurotrophic potencies of the immunophilin ligands resemble their potencies in binding

184 The immunophilin ligands show particular promise as a novel

185 ep and diurnal rhythm regulation, effects of immunophilin ligands, and cell surface oligosaccharides

186 Agents such as phosphodiesterase inhibitors, immunophilin ligands, and recombinant human erythropoiet

187 ve and regenerative therapies, including the immunophilin ligands, hold promise to reduce the morbidi

188 pressive properties of these clinically used immunophilin ligands, this holds promise for the neuropr

189 Since nonimmunosuppressive immunophilin ligands, which are devoid of calcineurin in

190 et of rapamycin (mTOR) binding region yields immunophilin ligands, WYE-592 and ILS-920, with potent n

191 s FKBP12, in contrast to previously reported immunophilin ligands.

192 tudy reveals a novel functional role for the immunophilin-like component of a soluble receptor comple

193 Mutation of the immunophilin-like FK506-binding protein TWISTED DWARF1 (

194 he 90-kDa heat shock protein (hsp90) and the immunophilin-like hepatitis B X-associated protein 2 (XA

195 tor (AhR) has been shown to interact with an immunophilin-like molecule known as AhR-interacting prot

196 imer of the 90-kDa heat shock protein and an immunophilin-like molecule, ARA9.

197 In addition, the immunophilin-like protein XAP2 was able to partially pro

198 Here, we show that hsp90.binding immunophilins link p53.hsp90 complexes to dynein and tha

199 These immunophilins link to cytoplasmic dynein indirectly thro

200 The immunophilins link to dynein indirectly via the dynamiti

201 and we show by peptide competition that the immunophilins link via their tetratricopeptide repeat do

202 plasmic shuttling, we analyzed whether these immunophilins modulate NF-kappaB signaling.

203 d the action of bastadin, suggesting that an immunophilin modulates Ry3R in parotid acini.

204 the peptidylprolyl-isomerase activity of the immunophilin nor its association with Hsp90.

205 r heterocomplexes exist depending upon which immunophilin occupies the TPR-binding region of hsp90.

206 Here, we report that an immunophilin of the chloroplast thylakoid lumen is requi

207 Here we show that an immunophilin of the cyclophilin type, CYP38, plays a cri

208 e, we ask if wheat germ lysate also contains immunophilins of the FK506-binding class (FKBPs) that bi

209 ant homologue to show that two hsp90-binding immunophilins of wheat, wFKBP73 and wFKBP77, bind to dyn

210 and so we examined in vivo the influences of immunophilins on hormone-dependent gene activation in th

211 ast mutant strains defective in calcineurin, immunophilins or other genes with the immunosuppressants

212 eterocomplexes that contain hsp90 and either immunophilins or, in the case of protein kinases, p50.

213 novel targets dependent upon calcineurin or immunophilins or, perhaps, specific targets of either Cy

214 nsity to dynamically associate with an Hsp90-immunophilin-p23 complex through its regulatory domain.

215 tively compete with trimeric hHSF1 for Hsp90-immunophilin-p23 complex, counteracting assembly of the

216 of genomic DNA encoding Schistosoma mansoni immunophilin p50 (Smp50) was identified on a 14-kb genom

217 Finally, two immunophilins, peptidyl-prolyl cis-trans isomerase F and

218 in indirectly through the association of the immunophilin peptidylprolyl isomerase (PPIase) domain wi

219 have previously proposed that hsp90 and the immunophilin play a role in receptor trafficking.

220 Although all immunophilins possess peptidyl-prolyl isomerase activity

221 These hsp90-binding immunophilins possess the signature peptidylprolyl isome

222 FKBP52 is a high molecular mass immunophilin possessing peptidylprolyl isomerase (PPIase

223 lin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian c

224 It is suggested that immunophilins promote the assembly of multiprotein compl

225 tion between the activin receptor R1 and the immunophilin protein FKBP12 can be disrupted by the smal

226 The immunophilin protein FKBP8 interacts with Bcl2/Bcl-XL an

227 ar mass of approximately 52 kDa (FKBP52), an immunophilin protein that interacts with physiological T

228 The protein targeted by the immunophilin-rapamycin complex is a member of a newly de

229 plex of the immunosuppressant rapamycin, its immunophilin receptor Fpr1p and Tor1p or Tor2p results i

230 imus (FK506) bind to unrelated intracellular immunophilin receptors, cyclophilin (CyP) and FK506-bind

231 The present data demonstrate that immunophilins regulate CrkII, but not CrkI activity in T

232 omplexes it is typically bound to one of the immunophilin-related co-chaperones: the peptidylprolyl i

233 is B virus X-associated protein 2 (XAP2), an immunophilin-related protein sharing homologous regions

234 cant implication in clinical applications of immunophilin-related therapeutic drugs.

235 Arabidopsis knock-out mutations in these immunophilins result in an increased susceptibility to P

236 To aid in the detection of the immunophilin's location in the receptor, we exchanged th

237 two groups of proteins (collectively called immunophilins) share little sequence homology, but both

238 ing each of the TRPC proteins along with the immunophilins showed that TRPC3, -C6, and -C7 interact w

239 Like immunophilins, Shut-down contains an FK506-binding prote

240 C3G) binding to CrkII, whereas inhibitors of immunophilins, such as cyclosporine A (CsA) and FK506, i

241 espectively), as well as high molecular mass immunophilins, such as FKBP59, and the small acidic prot

242 at contain TPR motifs include members of the immunophilin superfamily, organelle-targeting proteins,

243 FKBP52 is a steroid receptor-associated immunophilin that binds via a tetratricopeptide repeat (

244 e chaperones interact with Cyclophilin D, an immunophilin that induces mitochondrial cell death, and

245 FK506-binding protein 52 (FKBP52) is an immunophilin that possesses peptidylprolyl cis/trans-iso

246 FKBP52 is a widely expressed FK506-binding immunophilin that possesses peptidylprolyl isomerase act

247 06-binding protein 12.6/1b (FKBP1b), a small immunophilin that stabilizes RyR-mediated Ca2+ release i

248 y described progesterone receptor-associated immunophilin that, similar to FKBP52 and cyclophilin 40,

249 d animal cells contain high molecular weight immunophilins that bind via tetratricopeptide repeat (TP

250 We report a novel group of dual-family immunophilins that contain both CyP and FKBP domains for

251 FK506-binding proteins (FKBP) are immunophilins that interact with the immunosuppressive d

252 m cells contain one of several hsp90-binding immunophilins that link the complex to cytoplasmic dynei

253 e the fact that they bind to the same set of immunophilins, the FK506 binding proteins (FKBP).

254 These drugs exert their effects via immunophilins, the protein receptors for these agents.

255 The linkage of immunophilins to the dynein motor is indirect by means o

256 ADPH oxidase subunit p67 phox, hsp90-binding immunophilins, transcription factors, the PKR protein ki

257 of p53 or GR heterocomplexes with hsp90 and immunophilins was not affected by PFTalpha either in viv

258 of the FK506-binding protein (FKBP) class of immunophilins, was isolated.

259 this study was twofold: to determine whether immunophilins were present in the rat retina and to dete

260 Surprisingly, yeast mutants lacking all 12 immunophilins were viable, and the phenotype of the dode

261 The immunophilin, which can be of the FK506- or cyclosporin

262 Here we report that a novel Drosophila immunophilin, which we have named Zonda, is critically r

263 n this study, we investigated the ability of immunophilins, which function as peptidyl-prolyl isomera

264 eterocomplexes in L cell cytosol contains an immunophilin with high affinity FK506 binding activity,

265 propose that PP5 possesses properties of an immunophilin with low affinity FK506 binding activity an

266 A shows homology to cyclophilins, a class of immunophilins with a peptidyl-prolyl cis-trans isomerase

267 The association of immunophilins with the TRPC channels in rat brain lysate

268 ociated with FK506-binding proteins (FKBPs); immunophilins, with cis-trans peptidyl-prolyl isomerase

269 t belong to a subgroup of proteins, known as immunophilins, with peptidylprolyl cis-trans isomerase (

270 se (PDE4) isoform PDE4A5 interacted with the immunophilin XAP2 in a yeast two-hybrid assay.

271 d inserted in the vicinity of genes encoding immunophilin, zinc finger protein Sma-Zic, and others, a