ライフサイエンスコーパス: immunoregulatory

1 biologically active form of vitamin D and is immunoregulatory.

2 L and CD40, and exert a hitherto undescribed immunoregulatory action by enhancing IL-10 production an

3 Cytokines exert a vast array of immunoregulatory actions critical to human biology and d

4 These results indicated the immunoregulatory activities of licorice.

5 splants are acutely rejected, suggesting the immunoregulatory activities of liver nonparenchymal cell

6 ore, our uveitis data suggest that intrinsic immunoregulatory activities of other single chain IL-12

7 We have shown potent immunoregulatory activity of hepatic stellate cells (HSC

8 146a with a selective antagomir restored the immunoregulatory activity of nBMSCs.

9 Despite considerable progress regarding the immunoregulatory activity of this lectin, the role of en

10 atory T and Breg cells orchestrate a general immunoregulatory activity, which can be summarized as su

11 C in the injured spinal cord and explain its immunoregulatory activity.

12 Dendritic cells (DCs), the essential immunoregulatory and APCs, are major producers of the ce

13 with tumourigenesis, we found enrichment of immunoregulatory and cytoskeletal remodelling pathways,

14 LNs following oxidative stress, exhibits an immunoregulatory and hypostimulatory phenotype that is m

15 studies have shown that these compounds are immunoregulatory and immunosuppressive and thus may incr

16 ors (e.g., sirolimus; SRL) appear to be more immunoregulatory and might promote a tolerant state for

17 nchymal stem cells (AMCs) demonstrate unique immunoregulatory and precardiac properties.

18 rth and involves epigenetic modifications in immunoregulatory and proinflammatory pathways.

19 ature associated with HCC that includes both immunoregulatory and proliferative genes and that can al

20 IM-4hiCD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allo

21 strains of mice that have demonstrated novel immunoregulatory and remodelling/repair functions for th

22 tive products, interesting cardioprotective, immunoregulatory, and cardioregenerative properties have

23 Mesenchymal stem cells (MSCs) possess immunoregulatory, anti-inflammatory, and proangiogenic p

24 es in cancer are adoptive T-cell therapy and immunoregulatory antibodies.

25 Targeted interventions of this immunoregulatory axis may ameliorate tissue pathology in

26 pical HLA-F--and KIR receptors, acting in an immunoregulatory capacity centered on the inflammatory r

27 of IL-10 overexpression on the phenotype and immunoregulatory capacity of B cells.

28 miR-125a stabilizes both the commitment and immunoregulatory capacity of Treg cells.

29 atory 1 (BR1) cells and to investigate their immunoregulatory capacity through suppression of cellula

30 t here that CNIs compromise the overall Treg immunoregulatory capacity to a greater extent than would

31 gulator of immune activation that stabilizes immunoregulatory capacity while repressing the different

32 can protect against autoimmunity, including immunoregulatory CD4(-)CD8(-) double-negative (DN) T cel

33 Surprisingly, LRBA limits immunoregulatory cell numbers in tissues where GvHD is p

34 be more resistant to suppression mediated by immunoregulatory cell subsets, making them attractive fo

35 adipose tissue (VAT)-localized reduction in immunoregulatory cells and increase in proinflammatory i

36 Administering immunoregulatory cells to patients as medicinal agents i

37 our results demonstrate that recruitment of immunoregulatory cells to the diseased spinal cord in AL

38 ion, and was followed by the accumulation of immunoregulatory cells, including IL-10-producing monocy

39 Our findings indicate that the immunoregulatory changes of pregnancy reduce CTL selecti

40 In contrast, established immunoregulatory characteristics of Tregs had no functio

41 h by limited costimulation and triggering of immunoregulatory checkpoints that attenuate T-cell respo

42 We identify the immunoregulatory chemokine (C-C motif) ligand 28 (CCL28)

43 hibitory factor (MIF), a proinflammatory and immunoregulatory chemokine, were elevated in CLL patient

44 nstruct the generation of a highly effective immunoregulatory circuit encompassing tolerogenic DCs an

45 Here, we highlight immunoregulatory circuits engaging epithelial and mesenc

46 These data identify critical immunoregulatory circuits in B cells that may be targete

47 mmunity, whereas stimulation of Gal-1-driven immunoregulatory circuits will help to mitigate exuberan

48 Recently, we identified key immunoregulatory components of Streptococcus pneumoniae,

49 Hence, DCP acts as an immunoregulatory compound enhancing the antimycobacteria

50 ugh Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of VCAN proteolysis remain

51 We tested immunoregulatory CTLA4-Ig explicitly for its effect on T

52 n inhibitory factor (MIF), a proinflammatory immunoregulatory cytokine expressed constitutively, were

53 In the present study, we tested whether immunoregulatory cytokine fusion proteins of IL-10/Fc, T

54 alterations that reduce the function of the immunoregulatory cytokine IL-10 contribute to colitis in

55 The immunoregulatory cytokine IL-10 suppresses T-cell immuni

56 nd antimicrobial functions, to producing the immunoregulatory cytokine IL-10 was defined during exten

57 ile limiting CD4(+) T-cell production of the immunoregulatory cytokine IL-10.

58 S was found to be partially dependent on the immunoregulatory cytokine IL-10.

59 ion and whose expression correlates with the immunoregulatory cytokine IL-10.

60 A novel role for the macrophage-derived immunoregulatory cytokine IL-27 was identified in modula

61 Here, we show that the immunoregulatory cytokine interleukin-27 is upregulated

62 The immunoregulatory cytokine macrophage migration inhibitor

63 um of pregnant women are associated with the immunoregulatory cytokine TGF-beta1 and activated latent

64 Interleukin-10 (IL-10) is a key immunoregulatory cytokine that functions to prevent infl

65 IL-10 is an immunoregulatory cytokine that has broad effects across

66 -3 (IL-3), a hematopoietic growth factor and immunoregulatory cytokine, to resistance to blood-stage

67 IL-10 is an immunoregulatory cytokine, which in other infections can

68 plored whether IgA could regulate this other immunoregulatory cytokine.

69 inase family and is involved in signaling of immunoregulatory cytokines (type I and III IFNs, IL-6, I

70 Immunoregulatory cytokines may influence the hepatitis C

71 daptive response by their ability to produce immunoregulatory cytokines.

72 sformed cells and are important producers of immunoregulatory cytokines.

73 ion was further boosted with TCR agonists or immunoregulatory cytokines.

74 This conclusion suggests a deleterious immunoregulatory effect of TLR5 that may be mediated by

75 The exact role of IL-10 with its multiple immunoregulatory effects during CMV infection is not cle

76 have been shown to exert a range of similar immunoregulatory effects in murine and human experimenta

77 defense by desensitizing macrophages to the immunoregulatory effects of adenosine.

78 Here we investigate in detail the immunoregulatory effects of ChABC after SCI in rats.

79 Here, we discuss the tumorigenic and immunoregulatory effects of ER stress in cancer, and we

80 Although the immunoregulatory effects of FTY720 have been tested in c

81 We suggest that these immunoregulatory effects of PAD inhibition in CIA are co

82 In this study, we investigated immunoregulatory effects of the antimicrobial peptide RN

83 of a coinfecting pathogen can have profound immunoregulatory effects on an ongoing immune response.

84 used to delineate the commensal microbiota's immunoregulatory effects on osteoblastogenesis, osteocla

85 erase hydrolyses acetylcholine, which exerts immunoregulatory effects partly through TNF-alpha pathwa

86 We found that solTNF-alpha mediates these immunoregulatory effects primarily through TNFR1, becaus

87 unotherapy, but tools to broadly limit their immunoregulatory effects remain lacking.

88 Thus, CPT11 exhibited detrimental immunoregulatory effects that offset 5FU benefits when a

89 ns have attracted attention for their potent immunoregulatory effects.

90 ndence of these different cytokines in their immunoregulatory effects.

91 hanistic framework for how PSGs modulate the immunoregulatory environment at the maternal-fetal inter

92 lled preparation of Mycobacterium vaccae, an immunoregulatory environmental microorganism, reduced su

93 Conversely, the immunoregulatory enzyme IDO blocked loss of Eos and prev

94 onal DC populations and upregulated both the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO

95 ounds identified one potential target as the immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO

96 Indoleamine 2, 3-dioxygenase (IDO) is an immunoregulatory enzyme that breaks down tryptophan (Trp

97 Synthetic peptide immunoregulatory epitopes are a new class of immunothera

98 omical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the

99 eurons that likely contribute to assembly of immunoregulatory factors prior to infection, a more rapi

100 m1(+) effector regulatory T cells expressing immunoregulatory factors, such as Il10, Areg, Fgl2, and

101 Breast milk contains immunoregulatory factors, such as nano-sized vesicles na

102 Although immunoregulatory factors, such as Prostaglandin E2 (PGE2

103 on mTOR blockade, hMSCs also enhanced their immunoregulatory features.

104 the TIM-3 signaling events involved in this immunoregulatory function are yet to be established.

105 This NK's immunoregulatory function depends on the production of i

106 This previously unrecognized immunoregulatory function of D-mannose may have clinical

107 The results document a novel immunoregulatory function of eosinophils in helminth inf

108 However, the immunoregulatory function of ILC2s in the inflamed liver

109 ure, surface markers, IL-5 independence, and immunoregulatory function that is capable of polarizing

110 d to express neuronal stem cell markers lose immunoregulatory function when transferred into mice sen

111 lls, a group of innate T cells with critical immunoregulatory function.

112 sets, which are cell subsets associated with immunoregulatory function.

113 hat CB contains an abundance of B cells with immunoregulatory function.

114 demonstrate diminished Foxp3 expression and immunoregulatory function.

115 hesized by mononuclear phagocytes and exerts immunoregulatory functional activities on lymphocytic an

116 Its direct immunoregulatory functions and ability to induce novel n

117 superfamily (TNFRSF) members have important immunoregulatory functions and are of clear interest for

118 echanisms by which TFR cells exert their key immunoregulatory functions are largely unknown.

119 highly expressed in the lung where it exerts immunoregulatory functions dependent on being loaded wit

120 Therefore, our results suggest novel immunoregulatory functions for IFN-gamma to orchestrate

121 ains have revealed an expanded repertoire of immunoregulatory functions for this cell.

122 we review the most important features of the immunoregulatory functions for this enzyme.

123 In addition to their antimicrobial activity, immunoregulatory functions have been published for sever

124 Here we show that the IL-12p35 subunit has immunoregulatory functions hitherto attributed to IL-35.

125 esses, has recently been identified to exert immunoregulatory functions in a variety of inflammatory

126 Galectin-3 (gal3) is known for its immunoregulatory functions in infectious, autoimmune, an

127 gammadelta T cells have been shown to have immunoregulatory functions in several experimental autoi

128 and in vitro, suggesting that IDO may induce immunoregulatory functions of B cells in atherosclerosis

129 In this review we discuss the immunoregulatory functions of coinhibitory pathways and

130 The immunoregulatory functions of vitamin D have been well d

131 2RA) and new candidate loci with established immunoregulatory functions such as ADGRL2, TENM3, ANKRD3

132 Treg) lineage has been noted to exert potent immunoregulatory functions that contribute to specific g

133 lammation and cancer, associated with innate immunoregulatory functions that critically depend on lig

134 suggest that sIL-27Ralpha may play important immunoregulatory functions under normal and pathological

135 is important in delivering antimicrobial and immunoregulatory functions, and granzyme B, a critical c

136 g toward TH2 responses, which, together with immunoregulatory functions, are thought to limit the pot

137 ownstream of multiple receptor families with immunoregulatory functions, including members of the TNF

138 ting evidence that the microbiome has potent immunoregulatory functions.

139 eases is closely related to inflammatory and immunoregulatory functions.

140 ets, each of which is endowed with different immunoregulatory functions.

141 obial activity against diverse pathogens and immunoregulatory functions.

142 including antiviral, antiproliferative, and immunoregulatory functions.

143 homozygous loss-of-function mutation of the immunoregulatory gene Dock2 in several colonies of Irf5-

144 nt discovery of a homozygous mutation in the immunoregulatory gene guanine exchange factor dedicator

145 eration generally associated positively, and immunoregulatory gene sets negatively, with variant burd

146 revealed several rare, damaging variants in immunoregulatory genes as novel candidate mutations.

147 cyte injury/morphology and downregulation of immunoregulatory genes.

148 The immunoregulatory human leukocyte antigen (HLA) complex h

149 LR4 signaling was required for production of immunoregulatory IL-10 associated with prolonged allogra

150 In this review, we discuss the immunoregulatory influence of histamine on a number of g

151 ustrates how genomics yields new fundamental immunoregulatory insights as well as how research genomi

152 PDCs can thus orchestrate the beneficial immunoregulatory interaction of commensal microbial mole

153 Immunoregulatory interventions that act prophylactically

154 ate (immunostimulatory, IS-SNA) or regulate (immunoregulatory, IR-SNA) immunity by engaging TLRs have

155 article, we show that galectin-1 (Gal-1), an immunoregulatory lectin widely expressed in mucosal tiss

156 regulated MZB cell surface expression of the immunoregulatory ligand PDL1 in an ATF3-dependent manner

157 linc1992 THRIL (TNFalpha and hnRNPL related immunoregulatory LincRNA).

158 Here, we identify an immunoregulatory lincRNA, lincRNA-EPS, that is precisely

159 e elucidated the role of macrophage PGE2, an immunoregulatory lipid, in successful survival of Leishm

160 o-inflammatory (M1) and anti-inflammatory or immunoregulatory (M2).

161 ino acids such as arginine and tryptophan by immunoregulatory macrophages is one pathway that suppres

162 amma effects and promotes the development of immunoregulatory macrophages.

163 ses B. cinerea-induced activation of the key immunoregulatory MAPKs MPK3/MPK6 and reduces MPK3 protei

164 icroscopic parasitemia and expression of the immunoregulatory markers Tim-3 and CD57 were associated

165 Collectively, our study unravels a novel immunoregulatory mechanism of NAD(+) that regulates Treg

166 te B-cell help and are involved in an innate immunoregulatory mechanism through induction of itBreg c

167 unctions, increasingly provides insight into immunoregulatory mechanisms and thereby provides opportu

168 We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically pe

169 omplex set of interdependent and independent immunoregulatory mechanisms of IFN-beta, IL-27, and IL-1

170 Amino acid catabolism has been implicated in immunoregulatory mechanisms present in several diseases,

171 olerogenic responses via STING by activating immunoregulatory mechanisms such as indoleamine 2,3 diox

172 the need for novel approaches to circumvent immunoregulatory mechanisms that limit the induction of

173 However, the immunoregulatory mechanisms that prevent autoantibody pr

174 Remarkably, although immunoregulatory mechanisms were activated, they only pa

175 are robust new players involved in human MSC immunoregulatory mechanisms, and the higher suppressive

176 cacy is often inhibited through a variety of immunoregulatory mechanisms, including the PD1/PDL1 T-ce

177 r immunosuppressive activity through several immunoregulatory mechanisms, including the production of

178 tiple specific molecules, mobilizing various immunoregulatory mechanisms.

179 rated and therefore evolved roles in driving immunoregulatory mechanisms.

180 ase severity may be the outcome of lapses in immunoregulatory mechanisms; because as much, if not mor

181 Histamine is a key immunoregulatory mediator and can dampen proinflammatory

182 IL-17, but decreased the levels of systemic immunoregulatory mediators TGF-beta, myeloid-derived sup

183 ellate cells (HSC) are a major source of the immunoregulatory metabolite all-trans retinoic acid (ATR

184 ed at least in part through induction of the immunoregulatory molecule CD39 in DCs.

185 One key immunoregulatory molecule is Tim3.

186 NZB mice, despite the efficient induction of immunoregulatory molecules and high viremia, Cl13 genera

187 nly act as pro-inflammatory mediators but as immunoregulatory molecules that control the activation s

188 in C57BL/6 and BALB/c mice abundant negative immunoregulatory molecules, associated with T-cell exhau

189 regates in the peritoneum where they produce immunoregulatory molecules, including TSG6, that reduce

190 he immune response through the production of immunoregulatory molecules.

191 Patients with ACLF have increased numbers of immunoregulatory monocytes and macrophages that express

192 tion of T cell proliferation and function by immunoregulatory myeloid cells are an essential means of

193 central role for IFN-Is in orchestrating an immunoregulatory network leading to the dampening of pro

194 The complex immunoregulatory network of the epithelial barrier surve

195 populations and, in particular, the role of immunoregulatory networks in influencing antimalarial im

196 ns, but also highlight the broader impact of immunoregulatory networks on vaccine efficacy.

197 We review several key cellular and molecular immunoregulatory networks operational during Toxoplasma

198 Induction of immunoregulatory networks requires prolonged desensitiza

199 emergence, establishment, and maintenance of immunoregulatory networks that shape the immune response

200 act as effectors in both innate and adaptive immunoregulatory networks.

201 NK cells are more long-lived than canonical, immunoregulatory NK cells.

202 the long-sought foreign ligand for this key immunoregulatory NKR family and reveal how it controls t

203 k of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may prot

204 The liver is an immunoregulatory organ in which a tolerogenic microenvir

205 estern environment deprive the infant of the immunoregulatory organisms with which humans co-evolved,

206 o-evolved, while encouraging exposure to non-immunoregulatory organisms, associated with more recentl

207 Thus, we define an immunoregulatory pathway in which RAPA-sensitive mTORC1

208 response controls these parasites, many host immunoregulatory pathways and cellular networks are comm

209 e whereby both amino acid auxotrophy and the immunoregulatory pathways controlled by amino acids can

210 rders, due to their unique ability to induce immunoregulatory pathways in their hosts.

211 Altogether, our data expand the knowledge of immunoregulatory pathways of tick salivary proteins and

212 adult brain, differences in bioenergetic and immunoregulatory pathways were the major sources of hete

213 x stress response, metabolism, inflammation, immunoregulatory pathways, and tissue repair, providing

214 genes and 22 proteins, several important in immunoregulatory pathways, were expressed after conversi

215 verlapping and unique functions of these key immunoregulatory pathways.

216 r suppressive function, p53 controls several immunoregulatory pathways.

217 arkers, and strategies to bolster endogenous immunoregulatory pathways.

218 eads to the induction of macrophages with an immunoregulatory phenotype and the downregulation of inf

219 e an essential role for IL-10 in inducing an immunoregulatory phenotype in B cells that exerts substa

220 Indeed, this treatment induced an immunoregulatory phenotype in Th17 cells, which was mark

221 that predictive genomic biomarkers, but not immunoregulatory phenotyping, may be able to discriminat

222 ons, respectively, represent the extremes of immunoregulatory plasticity in the macrophage population

223 Here we review the current findings on the immunoregulatory plasticity of MSCs in disease pathogene

224 cells have recently been characterized as an immunoregulatory population highly enriched in the colon

225 plays a critical role in the control of the immunoregulatory potential of BMSCs.

226 Given the importance of DN T cells in immunoregulatory processes and their potential as target

227 ddition to host protection, it is clear that immunoregulatory processes are common in infected indivi

228 tory state also was temporally supplanted by immunoregulatory processes, suggesting a mechanism under

229 -overexpressing B cells acquired a prominent immunoregulatory profile comprising upregulation of supp

230 que splenic CD19(+) B cell with a functional immunoregulatory program is generated that promotes the

231 s function in T cells to coordinate distinct immunoregulatory programs within the lung that are permi

232 Here we demonstrate that B cells with immunoregulatory properties are enriched within both the

233 H2S antiviral and immunoregulatory properties could represent a novel trea

234 ent activation possesses proinflammatory and immunoregulatory properties critical for the development

235 ctively, our results describe key beneficial immunoregulatory properties for GIP in DIO and reveal th

236 ct human IL-10-producing B-cell subsets with immunoregulatory properties have been described.

237 enuate the effector potential while boosting immunoregulatory properties in Teff.

238 Human B cells with immunoregulatory properties in vitro (Bregs) have been d

239 Here, we will discuss non-classical immunoregulatory properties of C3 and C5 cleavage fragme

240 In an effort to highlight the varied immunoregulatory properties of fibroblastic reticular ce

241 The potent immunoregulatory properties of IL-10 can counteract prot

242 , we have shown that the cytokine IL-34, the immunoregulatory properties of which have not been previ

243 Helminths have strong immunoregulatory properties that may be exploited in tre

244 ed efficient cytokine producers endowed with immunoregulatory properties, but they can also become cy

245 ns, as well as the characterization of their immunoregulatory properties, is an emerging topic under

246 stromal cells (MSCs) possess reparative and immunoregulatory properties, making them attractive cand

247 ary polyunsaturated fatty acids (PUFAs) have immunoregulatory properties.

248 differential CD10 expression, exert opposite immunoregulatory properties.

249 of cells prior to apoptosis abolishes their immunoregulatory properties.

250 r isolation, to better define their specific immunoregulatory properties.

251 (NKT) cells are innate-like lymphocytes with immunoregulatory properties.

252 iously uncharacterized function of PSA as an immunoregulatory protease that could help to create an e

253 Human eosinophils contain stores of the immunoregulatory protein galectin-10.

254 t astrocyte-derived Gal-9 may function as an immunoregulatory protein in response to ongoing neuroinf

255 Expression of certain immunoregulatory proteins is modulated by prosurvival tr

256 ical Hodgkin lymphoma (cHL) express multiple immunoregulatory proteins that shape the cHL microenviro

257 radical prostatectomy to identify potential immunoregulatory proteins.

258 ersion increases systemic Tregs, DCregs, and immunoregulatory proteogenomic signatures in liver trans

259 provide crucial information on the different immunoregulatory qualities of PD-1 and IL-10 in progress

260 We investigated the contribution of the immunoregulatory receptor CD33 to a uniquely human postr

261 FCRL4 is an immunoregulatory receptor expressed by a subpopulation o

262 ber of the human gastric microbiota, elicits immunoregulatory responses implicated in protective vers

263 rogravity, radiation, and stress alter human immunoregulatory responses, which can in turn impact an

264 o generate adequate protective and balancing immunoregulatory responses.

265 nclusion that mast cells can mediate a novel immunoregulatory role during hematopoietic cell transpla

266 osed beekeepers suggest a similar functional immunoregulatory role for B cells in allergen tolerance

267 APCs, has been detected in B cells, yet its immunoregulatory role has only been explored on T cells.

268 Thus, mTOR plays an important immunoregulatory role in the germinal center, at least p

269 gammadeltaT cells play a crucial immunoregulatory role in the lung, maintaining normal ai

270 In this study, we aimed to investigate the immunoregulatory role of GIP in a murine model of diet-i

271 The immunoregulatory role of Lyst on TLR signaling pathways

272 39 expressed by Tregs may participate in the immunoregulatory role of Tregs.

273 ted antithrombotic activity, Efb can play an immunoregulatory role via inhibition of P-selectin-PSGL-

274 Despite this immunoregulatory role, it has been shown that Treg may a

275 or 1 (PDL-1/PD-1) pathway plays an important immunoregulatory role, particularly in the context of T

276 To examine their immunoregulatory role, we profiled miRNA expression in t

277 Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan metabo

278 CD40 plays dual immunoregulatory roles in Leishmania major infection and

279 e revealed that Mac-1 also plays significant immunoregulatory roles, and genetic variants in ITGAM, t

280 x production but additionally play important immunoregulatory roles, including choreographing immune

281 ells were originally named 'Treg' to reflect immunoregulatory roles, this also captures emerging, reg

282 ltures to assess their anti-inflammatory and immunoregulatory roles.

283 allergy, as well as more recently described immunoregulatory roles.

284 of apoptotic cells (ACs) is usually a potent immunoregulatory signal but can also promote inflammatio

285 ared with B6.Sle1b mice, indicating that Mer immunoregulatory signaling in APCs regulates B cell sele

286 IL-27R is an immunoregulatory signaling nod in autoimmune and infecti

287 es are exposed to metabolic, homeostatic and immunoregulatory signals of local or systemic origin tha

288 clearing apoptotic cells (ACs) and inducing immunoregulatory signals.

289 ab use (and hoped-for achievement of a truer immunoregulatory state), group B received lower TAC and

290 akes it an excellent model to identify novel immunoregulatory strategies that account for its niche a

291 viral perturbation, suggesting unrecognized immunoregulatory strategies.

292 lls and an increase in CD4(+)CD25(+)Foxp3(+) immunoregulatory T cells (Treg) in the periphery.

293 renal disease and increased the frequency of immunoregulatory T cells (Tregs) compared with leptin-su

294 Invariant NKT cells (iNKT) are potent immunoregulatory T cells that recognize CD1d via a semi-

295 s, and drive development of Foxp3-expressing immunoregulatory T cells.

296 eprogram intraepithelial CD4(+) T cells into immunoregulatory T cells.

297 t natural killer T (iNKT) cells are a potent immunoregulatory T-cell subset in both humans and mice.

298 rticular interest for the development of new immunoregulatory therapies.

299 d how this knowledge could be used to direct immunoregulatory therapy with antigen-specific regulator

300 ds to the activities of antibodies targeting immunoregulatory TNFRs expressed by T cells.