ライフサイエンスコーパス: immunostimulatory

1 issle 1917 and Thermus thermophilus were non-immunostimulatory.

2 to innocuous Ags that are not by themselves immunostimulatory.

3 ase pairs (bp) in length has been considered immunostimulatory.

4 acrophages and that these ssDNAs were highly immunostimulatory.

5 phocytes in order to evaluate their possible immunostimulatory abilities.

6 Whilst the mechanism behind its immunostimulatory action is not fully understood, the ab

7 ies of hIL-10 but lost the ability to induce immunostimulatory activities on some cells.

8 HDE immunostimulatory activities predicted the aeroallergen

9 Commensal bacteria possess immunostimulatory activities that can modulate host resp

10 eficient in SRA/CD204 display more effective immunostimulatory activities upon TLR4 engagement than t

11 opment, depending on their host-damaging and immunostimulatory activities.

12 destabilize double-stranded RNA reducing its immunostimulatory activities.

13 whose levels did not correlate exactly with immunostimulatory activities.

14 that enhancing FcgammaRIIB binding conferred immunostimulatory activity and considerably greater anti

15 for the inhibitory FcgammaRIIB in anti-CD40 immunostimulatory activity and suggest that isotype will

16 , Ca(2+), HMDM) with comparable efficacy and immunostimulatory activity as that of C3a in activating

17 l moieties have been shown to possess unique immunostimulatory activity creating a need for access to

18 diated XBP1 silencing in tDCs restored their immunostimulatory activity in situ and extended survival

19 In the present study, we characterized the immunostimulatory activity of pure synthetic hemozoin (s

20 The immunostimulatory activity of the intestinal microflora

21 The immunostimulatory activity of these compounds was also o

22 This endogenous immunostimulatory activity required nucleic acid and pro

23 4 ligation, and stronger proinflammatory and immunostimulatory activity than wild-type (WT) liver mDC

24 The dependence on FcgammaRIIB for immunostimulatory activity was not absolute, however, be

25 In order to correlate bioactive content with immunostimulatory activity we compared the abilities of

26 lecular components of Wigglesworthia exhibit immunostimulatory activity within tsetse is representati

27 ver targeting, increased half-life, enhanced immunostimulatory activity, and reduced cytotoxicity.

28 owever, the honeys differed greatly in their immunostimulatory activity, even within the same honey t

29 Thus, although haptens have immunostimulatory activity, it is distinct from classica

30 Because of their immunostimulatory activity, several TLR agonists are bei

31 new type of pathobionts that possess strong immunostimulatory activity, which is critical for alveol

32 dent chaperone grp170 (Ad.sgrp170), a potent immunostimulatory adjuvant and antigen carrier.

33 PC function, GM-CSF is being evaluated as an immunostimulatory adjuvant in a number of clinical trial

34 umor antigen material together with a highly immunostimulatory adjuvant.

35 , alone and in combination with a variety of immunostimulatory adjuvants, have induced various levels

36 Interestingly, beryllium did not act as an immunostimulatory agent as it does in Anurans and mammal

37 is demonstrated that monotherapy using this immunostimulatory agent significantly suppresses the tum

38 s a novel small molecule immunomodulator and immunostimulatory agent that triggers protective host in

39 r the therapeutic efficacy of a new systemic immunostimulatory agent, the Toll-like receptor-7 (TLR7)

40 rrently used in the clinic: cancer vaccines, immunostimulatory agents, adoptive T cell therapy, and i

41 , a US Food and Drug Administration-approved immunostimulatory agonist for Toll-like receptor-4, prom

42 Altogether, the results describe a novel immunostimulatory agonist targeted to the cytosolic RIG-

43 Immunostimulatory agonists such as anti-CD137 and interl

44 r microenvironment from immunosuppressive to immunostimulatory and contributed to inhibition of ovari

45 neable sequence and combined gene silencing, immunostimulatory and cytotoxic capacity of p-shRNA make

46 cular, we discuss the antagonism between the immunostimulatory and immunosuppressive effects of RT as

47 A delicate balance between immunostimulatory and immunosuppressive signals mediated

48 However, IFN signaling can be both immunostimulatory and immunosuppressive, and the factors

49 dulating immune responses on an axis between immunostimulatory and immunosuppressive.

50 hese data show that concomitant targeting of immunostimulatory and inhibitory checkpoints with immuno

51 lipids, or as a variant lacking GPL which is immunostimulatory and invasive in macrophage infection m

52 CpG(A)-STAT3 siRNA is immunostimulatory and nontoxic for normal human leukocyt

53 unity in patients with COPD by examining the immunostimulatory and tolerogenic properties of pulmonar

54 ors is a primary obstacle to the efficacy of immunostimulatory and vaccine approaches.

55 g Toll-like receptor 2 (TLR2) and are highly immunostimulatory and yet without apparent toxicity in a

56 The combination of radiotherapy with immunostimulatory anti-PD1 and anti-CD137 mAbs was condu

57 In patients with RRMM, elotuzumab, an immunostimulatory antibody, appears to provide clinical

58 ture of Rv0315 at 1.70 A resolution, a novel immunostimulatory antigen of Mtb, and demonstrate that R

59 ion, tRNA(Tyr) from Escherichia coli was not immunostimulatory, as were all tested eukaryotic tRNAs.

60 ion of Panx1 channels drives accumulation of immunostimulatory ATP versus immunosuppressive adenosine

61 s into the tumor, where they showed distinct immunostimulatory attributes.

62 Gs significantly overexpress mRNA of various immunostimulatory bactericidal proteins and alarmins, re

63 response was induced by surface exposure of immunostimulatory beta-glucans and was mediated by activ

64 ced by other factors, including unidentified immunostimulatory bioactives and immunosuppressive compo

65 proteins to each other in relation to their immunostimulatory capabilities.

66 nflammasome assembly and activation, and the immunostimulatory capacity and apoptotic predilection of

67 These data highlight the potential immunostimulatory capacity of a group of novel drugs, sr

68 role of hSOCS1 in negatively regulating the immunostimulatory capacity of DCs and imply a translatio

69 xpression resulted in the enhancement of the immunostimulatory capacity of DCs for T cell activation

70 uction by ECP and offer new insight into the immunostimulatory capacity of ECP.

71 Thus, the potent immunostimulatory capacity of IL-10-deficient DCs is due

72 Furthermore, the immunostimulatory capacity of rMG309c was localized spec

73 esis and may have implications regarding the immunostimulatory capacity of RNAP III transcripts.

74 Herein, we increased the immunostimulatory capacity of SPIONs by coating them wit

75 ation, PGE(2) has unfavorable effects on the immunostimulatory capacity of these cells.

76 ere was to determine the characteristics and immunostimulatory capacity, in vivo, of antigen and adju

77 optosis inducers but might also change their immunostimulatory capacity.

78 hat suppresses dendritic cell maturation and immunostimulatory capacity.

79 cipitation of infected cell lysates isolated immunostimulatory CCHFV RNA.

80 Moreover, like dendritic cells, immunostimulatory CD11b(+)Gr-1(+) cells can strongly cro

81 Adoptive transfer of these immunostimulatory CD11b(+)Gr-1(+) cells from ascites of

82 rt the unexpected finding that proliferating immunostimulatory CD11c(+) MHC class II(+) cDCs derived

83 environment) from an immunosuppressive to an immunostimulatory cell type.

84 transformed from immunosuppressive to highly immunostimulatory cells capable of triggering potent ant

85 ng-term functional memory following a single immunostimulatory challenge, leading to enhanced product

86 on other subsequent, and temporally distant, immunostimulatory challenges.

87 Therefore, introducing immunostimulatory chaperone grp170 in situ strongly prom

88 beta-cells; induced exosomal release of the immunostimulatory chaperones calreticulin, Gp96, and ORP

89 al release of intracellular autoantigens and immunostimulatory chaperones may play a role in the init

90 new concept that VBL may be used to design "immunostimulatory" chemotherapy regimens.

91 yinosinic:polycytidylic acid (poly I:C), and immunostimulatory complexes (ISCOMs).

92 This study is the first to reveal the immunostimulatory component of wheatgrass with well defi

93 erived from the outer membrane, they contain immunostimulatory components, especially lipopolysacchar

94 They differed in their contents of immunostimulatory components, including apalbumins, arab

95 s a major periodontal pathogen that contains immunostimulatory components.

96 eviously suggested that c-di-GMP is a potent immunostimulatory compound recognized by mouse and human

97 ke receptor (TLR)4 agonists are known potent immunostimulatory compounds.

98 rs enhanced the in vivo antitumor effects of immunostimulatory CpG DNA; however, TIM-3 overexpression

99 ed, delivering both tumor antigen(s) and the immunostimulatory CpG molecule to antigen-presenting cel

100 all interfering RNAs, and miRNAs, constitute immunostimulatory CpG motifs as an integral part of thei

101 tion with an oligodeoxynucleotide containing immunostimulatory CpG motifs, these Ags induce, in mice

102 Immunostimulatory CpG oligonucleotides (ODN) activate ce

103 tudy show the potential of using tumoricidal/immunostimulatory CpG-siRNA oligonucleotides as a novel

104 n to lipopolysaccharide (LPS), poly(I.C) and immunostimulatory (CpG) DNA.

105 unized with F and G proteins adjuvanted with immunostimulatory (CpG) oligodeoxyribonucleotides admixe

106 IL2 is an immunostimulatory cytokine for key immune cells includin

107 Among immunotherapeutic strategies, the immunostimulatory cytokine IL-15 could represent a serio

108 CP promotes marked release of the prototypic immunostimulatory cytokine IL-1beta.

109 anism, we evaluated NK cell responses to the immunostimulatory cytokine IL12.

110 dy-cytokine fusion protein consisting of the immunostimulatory cytokine interleukin-2 (IL-2) genetica

111 The immunostimulatory cytokine interleukin-2 (IL-2) is a gro

112 We reported that the immunostimulatory cytokine LIGHT (TNFSF14) in the microe

113 IL-15 is an immunostimulatory cytokine trans-presented with the IL-1

114 IL15, a potent immunostimulatory cytokine, both potentiates host T-cell

115 mokine ligand 17, and down-regulation of the immunostimulatory cytokine, IL-12.

116 d mice showed increased mRNA and protein for immunostimulatory cytokines and chemokines, as well as e

117 t upon specific recognition of TEM8 secreted immunostimulatory cytokines and killed tumor endothelial

118 Increased production of immunostimulatory cytokines in subjects carrying the hig

119 cytotoxic effect, were properly activated by immunostimulatory cytokines, and degranulated in the pre

120 E-cadherin-stimulated DCs failed to release immunostimulatory cytokines, exhibiting an entirely diff

121 with our previous evidence for reduction in immunostimulatory cytokines, is consistent with the obse

122 d reciprocal effects on suppressive MDSC and immunostimulatory DC expansion.

123 Immunostimulatory DCs are highly desired for the develop

124 ion, the ability of NK1R agonists to promote immunostimulatory DCs remains unexplored.

125 ata demonstrate that NK1R signaling promotes immunostimulatory DCs, and provide relevant insight into

126 nderstanding of the mechanisms and impact of immunostimulatory defective viral genomes generated duri

127 itional therapies have targeted T cells, yet immunostimulatory dendritic cells (DCs) are critical in

128 utoimmune diseases that show accumulation of immunostimulatory DNA and C3a.

129 AI in activation of NF-kappaB in response to immunostimulatory DNA appears to be analogous to sensing

130 FN-inducible protein 16 (IFI16), which bound immunostimulatory DNA directly and activated the stimula

131 CpG-containing immunostimulatory DNA sequences (ISS), which signal thro

132 micronuclei represent an important source of immunostimulatory DNA.

133 B activation as well as IFNbeta induction by immunostimulatory DNA.

134 of these, eRNA41H, combines (i) eRNA11a, an immunostimulatory dsRNA expressed by convergent transcri

135 Together, our data suggest HDACi are immunostimulatory during cancer treatment and that combi

136 To investigate the potential immunostimulatory effect of interleukin (IL) 2 as a huma

137 In this study, we demonstrated that the immunostimulatory effect of PIKA resulted in an increase

138 The mechanism behind the immunostimulatory effect of the cationic liposomal vacci

139 activity of chemotherapeutic agents-a direct immunostimulatory effect on DCs (chemomodulation)-and th

140 er reports, fibroblasts are shown to have an immunostimulatory effect upon activated T lymphocytes.

141 Moreover, a similar immunostimulatory effect was observed when the CD1d upre

142 nding that many chemotherapeutic agents have immunostimulatory effects has provided the impetus to co

143 rastuzumab, as both compounds mediated their immunostimulatory effects in strict dependence of target

144 nomodulatory actions are partly mediated via immunostimulatory effects in the liver.

145 s, indicating that SR-A is able to attenuate immunostimulatory effects of adjuvants or "danger" molec

146 (Stat3) plays a key role in down-modulating immunostimulatory effects of CpG.

147 reveals a key role for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade.

148 Antihistone IgG, which neutralizes the immunostimulatory effects of histones, suppressed intrar

149 In addition to well-established immunostimulatory effects of the microbiota, the presenc

150 Therefore, AHCC exerts immunostimulatory effects on intestinal epithelial cells

151 Thus, LGG+Bb12 induced systemic Th1 immunostimulatory effects on oral AttHRV vaccine that co

152 ffects on tumor cells as well as by indirect immunostimulatory effects on T and NK cells.

153 ed, the immunosuppressive drug rapamycin has immunostimulatory effects on the generation of memory CD

154 tumors can provoke parallel tumoricidal and immunostimulatory effects that bridge innate and adaptiv

155 LPS exerts potent immunostimulatory effects through activation of the TLR4

156 RNA molecules can cause potent cytotoxic and immunostimulatory effects through the activation of patt

157 ed cytosine/guanine (CpG) motifs, has potent immunostimulatory effects when coadministered with NY-ES

158 strands and the corresponding duplexes lack immunostimulatory effects, enhance nuclease resistance a

159 resulting in both cell autonomous as well as immunostimulatory effects.

160 re various species have different per capita immunostimulatory effects.

161 tone release during GN elicits cytotoxic and immunostimulatory effects.

162 has been suggested that some AGEs could have immunostimulatory effects.

163 lting in the elevation of exosome-associated immunostimulatory endogenous danger/damage associated mo

164 depletion of CD20(+) B cells creates a less immunostimulatory environment in the SLO reflected by re

165 higher amounts of potential celiac disease's immunostimulatory epitopes when compared to modern varie

166 Strong immunostimulatory events such as immunotherapy or infect

167 These islet MSC-like cells release highly immunostimulatory EXOs that could activate autoreactive

168 ed, thus allowing for controlled delivery of immunostimulatory factors and presentation of pathogen-a

169 respond to local inflammatory signals in an immunostimulatory fashion, the immune functions of skin-

170 Notably, when expressed in a more immunostimulatory form, the self-peptide inhibited the f

171 mune response to muramyl dipeptide (MDP), an immunostimulatory fragment of bacterial cell wall, but i

172 provides a novel strategy for augmenting the immunostimulatory function of DCs for inducing an effect

173 rganisms to benefit from the antioxidant and immunostimulatory functions that carotenoids fulfill.

174 (CD80 and CD86) molecules and have impaired immunostimulatory functions, such as antigen uptake and

175 ith integrated IL-15, a cytokine with potent immunostimulatory functions.

176 kine secretion and cell death in response to immunostimulatory fungal components.

177 sequences by site-specific mutagenesis in an immunostimulatory gene promoter allows its transcription

178 some of the oncogenic/inflammatory and Th-1 immunostimulatory genes are differentially regulated in

179 growth while inhibiting its binding to Th-1 immunostimulatory genes in growing tumors, including in

180 associated carbohydrate antigens (TACAs) and immunostimulatory glycolipids that hold promise as immun

181 Additionally, in vitro methylation of this immunostimulatory Gm18-negative tRNA with recombinant tr

182 l modification analysis, we identify several immunostimulatory 'hot spots' within the miRNA guide str

183 umor cells in vivo, that coexpression of the immunostimulatory IFN-beta gene would enhance the immune

184 cellular matrix and secrete higher levels of immunostimulatory IL-12p70 while producing reduced level

185 contrast to other cytokines that are usually immunostimulatory, IL-21 can induce apoptosis of murine

186 Uromodulin/Tamm-Horsfall protein is not immunostimulatory in the tubular lumen, but through unkn

187 rammed necrotic cell death causes release of immunostimulatory intracellular components after cell-me

188 P III), yet how these transcripts remain non-immunostimulatory is incompletely understood.

189 herical nucleic acids (SNAs) that stimulate (immunostimulatory, IS-SNA) or regulate (immunoregulatory

190 that induction of IDO-1 by a TLR-9 agonist, immunostimulatory (ISS) DNA, critically contributes to i

191 CD154 is an immunostimulatory ligand for CD40 that markedly influenc

192 focused on transcription induced by defined immunostimulatory ligands, such as lipopolysaccharide.

193 g profiles of other anti-cancer mAb, such as immunostimulatory mAb that stimulate or block immune rec

194 ge of the mechanisms of action of anti-CD137 immunostimulatory mAbs such as those currently undergoin

195 herapy can be synergistically augmented with immunostimulatory mAbs to act both on irradiated tumor l

196 -sized membrane vesicles that contain potent immunostimulatory materials.

197 , little is known regarding the induction of immunostimulatory mediators by ECP.

198 tic cells (DC) to selectively supplement the immunostimulatory miRNA miR-155.

199 racts with programmed death-1 (PD-1) and the immunostimulatory molecule CD80 and functions as a check

200 erived cyclic-di-AMP to be the key bacterial immunostimulatory molecule, the mechanism for IFNbeta ex

201 proteins convert inactive DNA into a potent immunostimulatory molecule.

202 hods for colocalized delivery of antigen and immunostimulatory molecules (i.e., adjuvants) are needed

203 TLR ligands and other allergen-nonspecific immunostimulatory molecules are ubiquitous in ambient ai

204 latory danger signals, arming the virus with immunostimulatory molecules can further improve efficacy

205 A can be exploited to generate a spectrum of immunostimulatory molecules for vaccine and therapeutics

206 antigens in the vesicle core and lipid-based immunostimulatory molecules in the vesicle walls under e

207 ovides rapid access to an important class of immunostimulatory molecules including the first reported

208 inflammatory response through the actions of immunostimulatory molecules referred to as damage-associ

209 ng environments contain allergen-nonspecific immunostimulatory molecules that influence the airway hy

210 nd pathogen-derived nucleic acids are highly immunostimulatory molecules that play a major role in th

211 NETs are toxic to the endothelium, expose immunostimulatory molecules, activate plasmacytoid dendr

212 une suppressive factors while inhibiting Th1 immunostimulatory molecules.

213 come about through the inhalation of Ag with immunostimulatory molecules.

214 n, in macrophages treated with LPS and other immunostimulatory molecules.

215 sses by refined adoptive T-cell transfer and immunostimulatory monoclonal Ab (mAbs).

216 pharmacodynamics and antitumor properties of immunostimulatory monoclonal antibodies (mAb) in setting

217 Elotuzumab, an immunostimulatory monoclonal antibody targeting signalli

218 me contains only a fraction of the number of immunostimulatory motifs present in murine CMV.

219 otal mammalian DNA, or DNA fragments lacking immunostimulatory motifs, fail to induce B cell prolifer

220 ted by these cancer-induced granulocyte-like immunostimulatory myeloid (CD11b(+)Gr-1(+)) cells, there

221 summary, the normal dermis contains typical immunostimulatory myeloid DCs identified by CD11c and BD

222 screening tool for the synthesis of new non-immunostimulatory nanocarriers.

223 report the development of a dual-functional, immunostimulatory nanomicellar carrier that is based on

224 st handled by antigen-presenting cells as an immunostimulatory nanoparticle.

225 s and an enhanced type I IFN response to the immunostimulatory nucleic acid polyinosinic:polycytidyli

226 by which RNase H2 may suppress generation of immunostimulatory nucleic acids.

227 cuss here an unexpected source of endogenous immunostimulatory nucleic acids: the reverse-transcribed

228 tive Hexose Correlated Compound (AHCC) is an immunostimulatory nutritional supplement.

229 We previously reported immunostimulatory oligodeoxynucleotides containing CpG m

230 model of melanoma subject to treatment with immunostimulatory oncolytic viruses and dendritic cell v

231 Host-damaging and immunostimulatory oral bacteria cooperatively induce bon

232 lated to vessel normalization correlate with immunostimulatory pathways, especially T lymphocyte infi

233 correlated with global downregulation of DC immunostimulatory phenotype and function.

234 +)Gr1(+) cells in the pancreas to acquire an immunostimulatory phenotype.

235 1c(+) cells invaded by cps were converted to immunostimulatory phenotypes, which expressed increased

236 Here we determined whether immunostimulatory plant-derived arabinogalactan proteins

237 ols the maturation, cytokine production, and immunostimulatory potency of DCs--restricted systemicall

238 ling the maturation, cytokine production and immunostimulatory potency of dendritic cells (DCs).

239 We analyzed the immunostimulatory potential of transfer RNA (tRNA) from

240 Gm18)-2'-O-methyltransferase (trmH) regained immunostimulatory potential.

241 through regulatory mechanisms that limit the immunostimulatory presentation of self antigens.

242 istinction, however, is that RET/PTCs induce immunostimulatory programs, suggesting that, in the case

243 Interferon-alpha (IFNalpha) has potent immunostimulatory properties and antiproliferative effec

244 We evaluated the immunostimulatory properties and overall virulence of cl

245 hetic CpG oligonucleotides (ODN) have potent immunostimulatory properties exploited in clinical vacci

246 te that CD20-targeted delivery overcomes the immunostimulatory properties of CpG-containing ON therap

247 Additionally, tunable immunostimulatory properties of described nanoparticles

248 We suggest that the immunostimulatory properties of honey may be influenced

249 3 kinase complex and, given the known strong immunostimulatory properties of IL-21 on CD8+ T, natural

250 Analysis of the immunostimulatory properties of interleukin-12 and its d

251 Given the known immunostimulatory properties of MPL and QS-21, the objec

252 ications of similar approaches in overcoming immunostimulatory properties of RNA-directed therapeutic

253 lack of invasiveness of S. maltophilia, the immunostimulatory properties of this organism and its in

254 In vitro evaluation of immunostimulatory properties revealed new potent TLR2 li

255 s (CpG ODN) are TLR9 ligands with attractive immunostimulatory properties, but intratumoral administr

256 ing lipoplexes in gene therapy lies in their immunostimulatory properties, so far attributed to the n

257 a low-toxicity derivative of LPS with useful immunostimulatory properties, which is nearing regulator

258 represents a novel TLR7 agonist with strong immunostimulatory properties.

259 TLR4, suggesting that MMTV intensifies these immunostimulatory properties.

260 ties of honey, and hence contribute to their immunostimulatory properties.

261 y increased externalization of bactericidal, immunostimulatory proteins, and autoantigens, including

262 aring mice at advanced stages of disease are immunostimulatory rather than being immunosuppressive.

263 Agonistic antibodies directed against immunostimulatory receptors belonging to the tumor necro

264 The adverse immunostimulatory responses were abrogated by selective

265 s," could be designed to efficiently deliver immunostimulatory RNA (isRNA) to TLR-expressing cells to

266 ted by the incorporation of RIG-I-activating immunostimulatory RNA into the vector backbone.

267 Immunostimulatory RNA was isolated from CCHFV-infected c

268 Toll-like receptor (TLR) 7 and 8 sensing of immunostimulatory RNA, independent of their miRNA-target

269 echanism for the intracellular metabolism of immunostimulatory RNA, with implications for specific au

270 Here we tested the immunostimulatory role of this lipid A modification.

271 oration of lipid A plays both protective and immunostimulatory roles and that host-derived CAMPs may

272 QS-21 is a potent immunostimulatory saponin that is currently under clinic

273 These studies show that a weakly immunostimulatory self-peptide can induce thymic and per

274 Moreover, a strongly immunostimulatory self-peptide expressed by B cells indu

275 at a key subset of these ncRNAs functions as immunostimulatory "self-agonists" and directly activates

276 existing VLP vaccines not naturally carrying immunostimulatory sequences.

277 n immune response, and the avoidance of this immunostimulatory signal is the reason for the observed

278 To increase the immunostimulatory signal, CD40L was engineered, by delet

279 HSPs and oxidative stress, may initiate the immunostimulatory signaling through glial TLRs.

280 c by the host only when malignant cells emit immunostimulatory signals (so-called "damage-associated

281 In the absence of co-administered immunostimulatory signals, APC-targeting can induce anti

282 refore assessed the efficacy of modified non-immunostimulatory siRNAs in a uniformly lethal non-human

283 These findings suggest that the class of immunostimulatory siRNAs may benefit from activation of

284 , nanotechnology can enhance the efficacy of immunostimulatory small molecules and biologics by alter

285 ate sensors despite massive transcription of immunostimulatory small RNAs (EBV-EBERs).

286 We previously developed an immunostimulatory strategy based on targeted Stat3 silen

287 y of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pn

288 ere it plays a key role in the activation of immunostimulatory T cells and acts as the primary recept

289 Liver-resident pDCs are considerably less immunostimulatory than those from secondary lymphoid tis

290 wn that ODNs containing two 5'-ends are more immunostimulatory than those with one 5'-end.

291 t infection of DCs with TriGAS may be highly immunostimulatory through mechanisms that enhance antige

292 bunit from LT-IIb-B(5) renders this molecule immunostimulatory through TLR2.

293 These findings indicate that SIV encodes immunostimulatory TLR ligands and that pDC, mDC, and mon

294 Accordingly, DNPs lacking immunostimulatory TLR9 ligands in DNA stimulated IFN-alp

295 bits C/EBPbeta activation, thus promoting an immunostimulatory transcriptional program that restores

296 The effect of the immunostimulatory transgene on overall virus potency can

297 Oncolytic adenoviral vectors that express immunostimulatory transgenes are currently being evaluat

298 by directing the conjugation of ubiquitin to immunostimulatory transmembrane proteins.

299 o occurred despite the continued presence of immunostimulatory viral Ag, indicating that the initial

300 TLR7 agonists are highly immunostimulatory without inducing dominant proinflammat