ライフサイエンスコーパス: impaired @1 function

1 ntiation, increased epidermal thickness, and impaired barrier function).

2 y defined glucocorticoid responsiveness, and impaired GR function.

3 were used to determine the ability to detect impaired LV function.

4 the mutation preventing H1 opening markedly impaired FAK function.

5 urther reduced protein synthesis in HSCs and impaired HSC function.

6 by overexpression of dominant negative Rab11 impaired NET function.

7 europsychiatric-related disease symptoms via impaired PFC function.

8 ory phenotype, which could contribute to the impaired TFH function.

9 death in these mice was not associated with impaired lung function.

10 and develop interventions for children with impaired lung function.

11 cytokine signature in pulmonary tissue, and impaired lung function.

12 pleural thickening, increased stiffness and impaired lung function.

13 essive sIgE production and directly affected impaired lung function.

14 epi LXA4, increased IL-8 concentrations, and impaired lung function.

15 ory of childhood violence victimization have impaired brain function.

16 s in WC-independent transcription of frq and impaired clock function.

17 ion of transplanted kidneys in patients with impaired graft function.

18 tion of transplanted kidney in patients with impaired graft function.

19 isordered endocardial-myocardial contact and impaired heart function.

20 ing from injury, disease or aging results in impaired motor function.

21 and produces signatures of brain injury and impaired motor function.

22 inflammation, apoptosis, cyst formation, and impaired renal function.

23 It is an early marker of impaired renal function.

24 sessment of concomitant valve disease and/or impaired renal function.

25 ctions, and all-cause death in patients with impaired renal function.

26 an be elevated by overweight, older age, and impaired renal function.

27 dly increased risk that is independent of an impaired renal function.

28 because of the complexity of their care and impaired renal function.

29 xaban-treated patients with normal or mildly impaired renal function.

30 na, hospital admission for heart failure, or impaired renal function.

31 described as a sensitive marker in detecting impaired renal function.

32 development of diabetes, and development of impaired renal function.

33 and increased T-circle formation, suggesting impaired RTEL1 function.

34 te-cell synapses but simultaneously severely impaired their function.

35 S. mutans, and FLAG tagging of the peptides impaired their function.

36 ation limits LV backflow under conditions of impaired valve function.

37 er regulatory factor-1 that have selectively impaired ductal function.

38 d production of peripheral B lymphocytes and impaired immune function.

39 tence and may reactivate in individuals with impaired immune function.

40 have an increased incidence of cancer due to impaired immune function.

41 ations between exposure and hypertension and impaired kidney function.

42 ap may be informative; or, in the context of impaired kidney function.

43 of metformin in patients with significantly impaired kidney function.

44 ipofuscin material, damaged mitochondria and impaired muscle function.

45 structure in the sieve areas associated with impaired phloem function.

46 long-term immune alterations associated with impaired thymic function.

47 ession of intestinal junctional proteins and impaired barrier function.

48 at E17.5 in Hsd11b2(-/-) fetuses, suggesting impaired cardiac function.

49 +/- 2.7%; p < 0.01), and was associated with impaired cardiac function.

50 all change in synapses numbers, but strongly impaired synapse function.

51 arousal in seizures as a novel mechanism for impaired cortical function.

52 ng per se without the confounding effects of impaired physical function.

53 ing per se without the confounding impact of impaired physical function.

54 ted with reduced ceramide levels in skin and impaired platelet function.

55 hippocampal neurons, increased anxiety, and impaired cognitive function.

56 ased expression of CD16, perforin, CD57, and impaired cytolytic function.

57 erized by a reduced LV ejection fraction and impaired diastolic function.

58 fic CD8(+) T cells from Nlrc5(-/-) mice have impaired effector functions.

59 scle fat content, impaired leg strength, and impaired metabolic function.

60 ed progressive pulmonary fibrosis leading to impaired pulmonary function.

61 reased, implying a molecular response to the impaired lusitropic function.

62 also had delayed progesterone withdrawal and impaired myometrial function.

63 ed from healthy volunteers and patients with impaired neutrophil function.

64 vated blood pressure and are associated with impaired endothelial function.

65 isk by promoting a proinflammatory state and impaired endothelial function.

66 therapeutic strategy in disorders involving impaired hippocampal function.

67 ecies mechanistically linked TAZ mutation to impaired cardiomyocyte function.

68 dict a poor outcome, probably as a result of impaired mitochondrial function.

69 scle atrophy, reduced force development, and impaired mitochondrial function.

70 e population of processing intermediates and impaired mitochondrial function.

71 represent a potentially remediable cause of impaired socioeconomic function.

72 uses developmental cardiac abnormalities and impaired cardiovascular function.

73 sive-compulsive disorder (OCD) are caused by impaired frontostriatal function.

74 d host proteome in CD patients indicative of impaired mitochondrial functions.

75 iarrheal episodes (25% vs 46%; P = .048) and impaired intestinal function (48% vs 72%; P = .027).

76 Importantly, we demonstrate that impaired p53 function, a characteristic of many cancers,

77 Ad-GsKO mice had impaired BAT function, absent browning of WAT, and reduc

78 posure was associated with elevated risks of impaired adult functioning across all outcome measures.

79 finition for cardiac PGD comprising severely impaired systolic function affecting one or both ventric

80 ADAP-deficient TRM cells exhibited impaired effector function after Ag rechallenge, correla

81 An impaired renal function also leads to 1,25-vitamin D3 de

82 ropensity for asthma; hay fever; eczema; and impaired lung function, also in children without an esta

83 cally uninvolved skin in TGM3/KO mice showed impaired barrier function and higher susceptibility to F

84 ng in brown adipose tissue (BAT), leading to impaired BAT function and thermoregulation.

85 and age-related changes that could underlie impaired brain functioning and impact social and communi

86 post-acute phase of injury who have markedly impaired CC functioning and structural integrity that is

87 many Parkinson's disease patients including impaired cognitive function and increased anxiety-like b

88 Chronic exposure to PPIs impaired endothelial function and accelerated human endo

89 l depletion from the endothelium, triggering impaired eNOS function and limiting BH4 rescue through N

90 , we test whether cannabis abusers (CA) have impaired frontal function and reactivity to dopaminergic

91 In conclusion, pretransplant COPD, impaired graft function and the occurrence of serious po

92 Similarly, patients with AD show impaired insulin function and glucose metabolism.

93 Substitutions at the dimer interface impaired IreB function and stability in vivo, indicating

94 including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2R

95 um metabolite concentrations may result from impaired kidney function and can be used to estimate fil

96 Impaired kidney function and earlier menopause were asso

97 TMA in humans, these mice exhibited severely impaired kidney function and hypertension.

98 to determine whether the association between impaired kidney function and venous thrombosis can be ex

99 Factors explaining the association between impaired kidney function and venous thrombosis have not

100 ion largely explains the association between impaired LA function and higher risk of HF hospitalizati

101 eover, chemical inhibition of 15-LO function impaired LSC function and attenuated CML in mice.

102 (COPD) is a complex disease characterized by impaired lung function and airway obstruction resulting

103 th lymphangioleiomyomatosis correlating with impaired lung function and angiomyolipoma presence.

104 are associated with childhood onset, atopy, impaired lung function and in some, smoking.

105 Deletion of any of these channels results in impaired macrophage function and increased susceptibilit

106 resents a potentially important link between impaired metabolic function and degenerative disorders.

107 suggest that APOO represents a link between impaired mitochondrial function and cardiomyopathy onset

108 ng of cardiac mitochondrial function because impaired mitochondrial function and dynamics and contrac

109 and oxidation in skeletal muscle, leading to impaired mitochondrial function and increased oxidative

110 Loss of FXN causes impaired mitochondrial function and iron homeostasis.

111 on of either parkin or RET in neuronal cells impaired mitochondrial function and morphology.

112 in critically ill patients is accompanied by impaired mitochondrial function and structure, and by in

113 se changes are likely to be accounted for by impaired mitochondrial function and to involve phospholi

114 d anesthetics causes neurotoxicity including impaired neurocognitive function and abnormal behavior.

115 csq-1 deletion impaired pharynx function and caused missed pumps during

116 Night blindness can result from impaired photoreceptor function and a subset of cases ha

117 , obtained by a knockdown approach, leads to impaired photoreceptor function and abnormally shaped ph

118 ematopoietic TFs implicated in patients with impaired platelet function and number include runt-relat

119 ut integral part of the cellular response to impaired proteasome function and altered proteostasis.

120 s (mAbs) N29 and KIM-127, is associated with impaired pulmonary function and airway eosinophilia, res

121 riant together with its normal version) have impaired receptor function and showed sleep disturbances

122 ients than before are receiving diagnoses of impaired renal function and nephrosclerosis-age-associat

123 sure-volume catheterization studies revealed impaired systolic function and prolonged diastolic relax

124 H exposure was significantly associated with impaired Treg function and increased methylation in the

125 agmentation results in enhanced, rather than impaired, mitochondrial function and is mediated, in par

126 structures are one of the main indicators of impaired biological function, and hence, the ability to

127 to attenuate neuronal cell death, vasospasm, impaired cognitive function, and clearance of cerebral b

128 critical RNA- and DNA-binding proteins, (c) impaired cytoskeleton function, and (d) non-neuronal cel

129 contributes to defective IRE1alpha activity, impaired ER function, and prolonged ER stress in obesity

130 ssion characterized by reduced extraversion, impaired executive function, and decreased positive emot

131 gatroban is contraindicated in patients with impaired liver function, and activated partial thrombopl

132 elative to WT, with accelerated weight loss, impaired lung function, and exacerbated alveolar inflamm

133 significantly inhibited nuclear maturation, impaired mitochondria function, and damaged the spindle

134 y day of life five abcd1 mutants demonstrate impaired motor function, and overall survival to adultho

135 al complications, including muscle weakness, impaired physical function, and decreased health-related

136 l physical and psychological symptom burden, impaired physical function, and inferior survival compar

137 Diabetes mellitus, impaired renal function, and reduced 6-minute walk dista

138 PAD patients often have impaired renal function, and the blood concentration of

139 correlation with reduced TACI expression and impaired TACI function, APRIL or BAFF did not activate t

140 D patients, altered fibrinogen structure and impaired fibrinogen function are associated with neutrop

141 HF myocardium exhibited impaired contractile function as evidenced by reduced ma

142 Considering multiple reports implicating impaired lysosome function as a driver of increased amyl

143 hildhood cancer survivors may be at risk for impaired psychosexual functioning as a direct result of

144 evealed that infection with CVB3 resulted in impaired heart function, as illustrated by a drastically

145 Impaired kidney function, as measured by reduced estimat

146 Cohen syndrome patients likely results from impaired COH1 function at the Golgi complex, causing dec

147 d prolyl-hydroxyproline-were associated with impaired executive function at the false-detection rate

148 ) had stable graft function and 16 (36%) had impaired graft function at the time of dnDSA detection.

149 nt profile of empagliflozin in patients with impaired kidney function at baseline was similar to that

150 en urinary cadmium(UCd) and hypertension and impaired kidney function at low exposure levels (UCd: GM

151 Consequently, impaired PKD functions attenuate activity-dependent chan

152 This report shows that impaired SERCA2 function, both in DD keratinocytes and i

153 ith clinical end points in participants with impaired kidney function, but not in participants with n

154 Furthermore, Alox15 deletion impaired LSC function by affecting cell division and apo

155 A composite of death, dialysis, or sustained impaired renal function by day 30 after surgery did not

156 outcomes, including respiratory infections, impaired lung function, cardiac infarctions, and cancers

157 required for normal VLDL secretion and that impaired TM6SF2 function causally contributes to NAFLD.

158 diac remodeling post-MI leads to progressive impaired cardiac function caused by a disarray of severa

159 TCs) was halted in the embryonic thymus, and impaired NIK function caused a selective loss of IL-17 e

160 We found that obese mice have impaired lymphatic function, characterized by leaky capi

161 aged Calstabin2 KO mice exhibited a markedly impaired cardiac function compared with WT littermates.

162 ignificant left ventricular hypertrophy, and impaired diastolic function compared with all other grou

163 ior research demonstrating that smokers have impaired inflammatory functioning compared with non-smok

164 Children on antihypertensive medication had impaired physical functioning compared with other LT pat

165 Impaired physical functioning correlated with decreased

166 ng of the mouse EAE spinal cord reveals that impaired neurological function correlates with the depol

167 In patients with impaired renal function creatinine/eGFR levels remained

168 Strain imaging detects impaired systolic function despite preserved global LVEF

169 Impaired visual function, detected as a deficit in the s

170 It is generally accepted that impaired immune function due to immunosuppression is a p

171 o-pituitary-adrenal (HPA) axis activity with impaired hippocampal function during aging, the idea has

172 s with hypertension was mainly attributed to impaired kidney function (eGFR: 30%; urinary albumin: 5%

173 r 1.73 m(2); n=722) to 57%-61% with severely impaired renal function (eGFR<30 ml/min per 1.73 m(2); n

174 Impaired microglial function, either through aberrant ac

175 l pathways for stillbirth frequently involve impaired placental function, either with fetal growth re

176 : +44%) shortly after exposure (30 min), and impaired motor functions (falls: +83%; time top: -43%; t

177 The trajectory consisting of impaired lung function from birth throughout childhood i

178 Specificity decreased with impaired renal function from 93%-95% with normal functio

179 110 and 75 mg BID in patients with normal or impaired renal function (glomerular filtration rate >80

180 Those with impaired graft function had more graft failures; however

181 Eighty-eight percent of patients with impaired graft function had rejection.

182 Those patients with impaired graft function had significantly lower estimate

183 siological causes remain uncertain, although impaired myometrial function has been implicated.

184 Children and adults with asthma and impaired lung function have been reported to have low-gr

185 cterized by enlarged ventricular dimensions, impaired cardiac function, heart failure and high risk o

186 activation associated with HIV infection and impaired pTfh function heighten deficiencies in antibody

187 centration was significantly associated with impaired ventricular function, highlighting the importan

188 To avoid long-term costs of impaired academic functioning, households below 150% of

189 Impaired mitochondrial function impacts many biological

190 ncers, as well as multiple myeloma-exhibited impaired muscle function, implicating a role for the tum

191 CN maturational profiles can reliably detect impaired attention functioning in youth.

192 There is evidence of an impaired barrier function in EoE that might allow pathog

193 R1 in intestinal epithelial cells results in impaired barrier function in vitro.

194 -volume conductance catheterization revealed impaired cardiac function in 2-month-old male transgenic

195 es (DNMTs) in embryonic heart and results in impaired cardiac function in adulthood.

196 This study deepens our understanding of impaired cardiac function in diabetes, identifies GCH1 a

197 TNC deficiency further impaired cardiac function in response to pressure overlo

198 scent marijuana use is often associated with impaired cognitive function in adulthood.

199 mans and have implications for understanding impaired cognitive function in disorders affecting conne

200 rning and memory processes may contribute to impaired cognitive function in individuals with METH-ind

201 Various components of impaired community functioning in schizophrenia followed

202 down-regulation of BK channel activation and impaired coronary function in diabetes.

203 R phosphorylation profile and stability, and impaired dPER function in the circadian negative feedbac

204 led to increased oxidative stress as well as impaired endothelial function in ApoE-deficient mice.

205 n, and in silico homology modeling predicted impaired GAP function in the corresponding mutant.

206 l mechanism of late up-regulation of EP4 and impaired gliding function in EP4cKO(S100a4) tendon repai

207 h in the immediate posttransplant period and impaired islet function in the longer term.

208 erebellum appear to be the most sensitive to impaired ITPR1 function in humans.

209 rthermore, human SHROOM3 variants can induce impaired kidney function in animal models.

210 w may lead to smaller kidneys and subsequent impaired kidney function in later life.

211 exacerbated cystic and fibrotic lesions and impaired kidney function in these mice, consequently lea

212 atopic dermatitis (AD), asthma, wheezing and impaired lung function in a prospective study of Danish

213 alanced by an opposite effect resulting from impaired lymphatic function in ubiquitous Panx1-deficien

214 erglycemia are independently associated with impaired microvascular function in the retina and skin.

215 Furthermore, we found impaired mitochondrial function in hepatocytes of Zdhhc1

216 Metabolic syndrome also associates with impaired nerve function in people without polyneuropathy

217 in vitro and in vivo and has been linked to impaired neurocognitive function in humans.

218 These data indicate that impaired neurocognitive function in some children with C

219 oss results in demyelination, which leads to impaired neurological function in a broad array of disea

220 studying molecular mechanisms underlying the impaired neuronal functions in FXS.

221 lysis of molecular mechanisms underlying the impaired neuronal functions in FXS.

222 first year postinfection was associated with impaired protein function in some controllers.

223 I is associated with increased mortality and impaired renal function in the first postoperative year.

224 homeostatic response gone awry and underlie impaired synaptic function in HAND.

225 thology are associated with inflammation and impaired synaptic function in the hippocampal CA1 region

226 ock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differ

227 nger regulatory factor-1, which specifically impaired ductal function, increased the severity of acut

228 Statin myalgia was associated with impaired muscle function, increased abdominal adiposity,

229 ating gluten-specific CD4(+) T cells but had impaired suppressive function, indicating that Treg cell

230 Incorporation of impaired cognitive function into routine preoperative ri

231 Impaired conduit function is associated with impaired ea

232 Impaired DHCR7 function is associated with a spectrum of

233 he JAK1-deficient cells demonstrate that the impaired JAK1 function is mainly attributable to the eff

234 nitive dysfunction is solely attributable to impaired renal function is unclear.

235 Impaired social functioning is pervasive in schizophreni

236 al studies showed that the Glu185Lys variant impaired autophagic function leading to the accumulation

237 Altered protein turnover due to impaired COP1 function led to accumulation and enhanced

238 We propose that impaired mitochondrial function marks the progression fr

239 Impaired ECFC function may contribute to arrested alveol

240 Increased inflammation and impaired endothelial function may be pathways by which c

241 We hypothesize that ethanol-impaired giantin function may be related to altered traf

242 metabolism of these drugs in the setting of impaired kidney function may subject patients with CKD t

243 production of eotaxin-3 [encoded by CCL26]), impaired barrier function (mediated by loss of desmoglei

244 ith excessive manganese accumulation was the impaired motor function observed in the Zip14 KO mice.

245 Impaired mitochondrial function occurred before intracel

246 Here we report that impaired channel function of TRPM7 in MKs causes macroth

247 ced proliferation, target tissue homing, and impaired effector function of allogenic donor T cells.

248 An impaired mitochondrial function of atherosclerotic-MSCs

249 lying amino acids, and may contribute to the impaired protein function of the Polg mutant mice.

250 numbers of hematopoietic stem cells (HSCs), impaired radioprotective function of hematopoietic proge

251 ce checkpoint dysfunction is associated with impaired suppressive function of WAS regulatory T cells.

252 Multiple tumor-derived KDM2B mutations impaired the function of KDM2B to target c-Fos degradati

253 1 and Id3) in Gfi-1(-/-) mice did not rescue impaired HPC function or erythropoiesis.

254 Hyperkalemia is common in patients with impaired kidney function or who take drugs that inhibit

255 nfants are predisposed to illness because of impaired lung function or whether respiratory illness re

256 nd epigenetic errors that eventually lead to impaired organ function or catastrophic transformation s

257 interval (CI): 1.104, 1.953; P = 0.008) and impaired kidney function (OR = 1.902, 95% CI: 1.054, 3.4

258 Impaired mitochondrial function, oxidative stress and fo

259 llation (P < .001), diabetes (P < .001), and impaired renal function (P < .001); and had higher N-ter

260 Impaired cardiac function persists in the era of effecti

261 m testosterone level less than 275 ng/mL and impaired sexual function, physical function, or vitality

262 For most PTCs, impaired secretion/function produced by readthrough-medi

263 Obesity was associated with impaired diastolic function regardless of MS status, as

264 olecular and cellular mechanisms involved in impaired neutrophil function remain incompletely defined

265 etween higher sputum endotoxin levels and an impaired lung function response to oral corticosteroids,

266 Impaired MCUC function, resulting from down-regulation o

267 neurons lack rootlets and have dramatically impaired sensory function, resulting in behavior defects

268 iated with focal or global brain overgrowth, impaired TBCK function results in progressive loss of br

269 We used mice of both sexes to show that impaired Tcf4 function results in consistent microcephal

270 Impaired ventricular function (right or left ventricular

271 Impaired RV function (RV ejection fraction </=50%) was p

272 e a cellular and molecular framework for how impaired torsinA function selectively disrupts neural ci

273 ale-early-childhood-onset-atopic-wheeze-with-impaired-lung-function showed female predominance, high

274 pheral arterial, cardiovascular disease, and impaired renal function significantly so, among HIV-infe

275 Poor glycaemic control and impaired renal function substantially increased the risk

276 ilencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA re

277 sis and may contribute to the development of impaired adrenocortical function that is thought to cont

278 AP-HSV showed impaired vasomotor function that was associated with inc

279 ere, we show SDHD-G12S and SDHD-H50R lead to impaired PTEN function through alteration of its subcell

280 Several studies have linked impaired AMPK function to peripheral metabolic diseases

281 chanisms linking fibrosis, inflammation, and impaired ventricular function to DPP4 inhibition in prec

282 s. 0.017 +/- 0.002 s(-1)), and significantly impaired diastolic function (transmitral early diastolic

283 Here we demonstrate that impaired JunB function via gene silencing or overexpress

284 Impaired executive function was defined as a score >/=2

285 sociation between 4-hydroxyphenylacetate and impaired executive function was replicated in the second

286 Further, impaired myocardial function was strongly correlated wit

287 In univariate analysis impaired pulmonary function was significantly associated

288 Impaired renal function was determined via urinary album

289 a gradient of increasing severity, all-cause impaired visual function was associated with adverse soc

290 infarction, peripheral arterial disease, and impaired renal function were significantly more prevalen

291 UpperB exposure impaired mitochondrial function, whereas LowerB exposure

292 Choline deficiency also impaired mitochondria function, which was observed by a

293 r people face a high risk of muscle loss and impaired physical function, which may contribute to sarc

294 cellular TFV-DP concentrations, both equally impaired barrier function, while wound closure was more

295 The LQT mutant K526E revealed a severely impaired channel function with a right shift in the volt

296 hear stress further deteriorates the already impaired endothelial function with attendant endothelial

297 They had impaired lung function with high Feno values and total I

298 We show that these animals have severely impaired cardiac function, with a median survival of 22

299 tion in HEK293 Tet-on G1 and G2 cells led to impaired mitochondrial function, with markedly reduced m

300 to supraphysiological glucose concentration impaired SOCs function without altering the expression l