ライフサイエンスコーパス: impairment

1 uster synthesis is the primary cause of this impairment.

2 th renal TILs correlated with renal function impairment.

3 developmental defects nor signs of cognitive impairment.

4 mprove recovery from persistent sensorimotor impairment.

5 on therapy, and substantial hepatic or renal impairment.

6 of predictability in post-stroke functional impairment.

7 s progressive and may lead to serious visual impairment.

8 hinitis and/or ocular symptoms suffered work impairment.

9 We report anatomically specific patterns of impairment.

10 or chronic liver disease (CLD) with hepatic impairment.

11 eference values for the emergence of balance impairment.

12 ajor cause of age-related vascular cognitive impairment.

13 zed scaling, erythema, and epidermal barrier impairment.

14 l concurrent medical disorders and cognitive impairment.

15 of hepatic steatosis to subclinical vascular impairment.

16 entions to modify attention bias and related impairment.

17 protect these mice from developing cognitive impairment.

18 x III, causing its structural and functional impairment.

19 macrophages of patients with mild cognitive impairment.

20 psychotic symptoms, and short-term cognitive impairment.

21 maintaining eye health and preventing visual impairment.

22 erve were associated with post-HCT cognitive impairment.

23 erious mental health problems and functional impairment.

24 of schizophrenia and mechanisms of cognitive impairment.

25 spasticity and (3) global neurodevelopmental impairment.

26 und muscle action potentials and presynaptic impairment.

27 ins in patients suffering visual and hearing impairment.

28 comes and the impact on blindness and visual impairment.

29 lination might augment sensorineural hearing impairment.

30 l use in the treatment of vascular cognitive impairment.

31 than 60 years of age with severe functional impairment.

32 rmulations may lead to a mild ocular surface impairment.

33 ic reticulum (ER), leading to its functional impairment.

34 neuronal apoptosis and later neurocognitive impairment.

35 ngle (NFT) formation, resulting in cognitive impairment.

36 e neural basis of social behavior and social impairment.

37 ied characteristics associated with any IADL impairment.

38 at cortical tau is associated with cognitive impairment.

39 terized by rapidly progressive severe visual impairment.

40 s well as contextual fear and spatial memory impairments.

41 metacognitive and perceptual decision making impairments.

42 tated earlier hearing aid fitting for milder impairments.

43 grooming, hyperanxiety and social behavioral impairments.

44 mage, often resulting in long-term cognitive impairments.

45 motor neuron dysfunction and motor behavior impairments.

46 strategies largely fail to ameliorate these impairments.

47 n that correlate with more severe behavioral impairments.

48 rs characterized by cognitive and behavioral impairments.

49 of AD-like pathophysiological and cognitive impairments.

50 In the 10 years after the initial impairment, 16% (CI, 14% to 18%) had 1 or more episodes

51 h low testosterone and age-associated memory impairment (AAMI).

52 tionship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum.

53 tion was independently associated with renal impairment (adjusted odds ratio [aOR] = 2.1; 95% confide

54 Cognitive impairment after major noncardiac surgery and critical i

55 SK2656157 would be beneficial against memory impairment after TBI.

56 The risks and implications of cognitive impairment after WBRT should be considered at the time o

57 e the gliovascular damage and working memory impairments after hypoperfusion possibly via endothelial

58 er of people with moderate and severe visual impairment also increased, from 159.9 million (80% UI 68

59 g 10 probable AD, 15 amnestic mild cognitive impairment (aMCI), and 10 cognitively healthy controls (

60 sociated with an increased risk of cognitive impairment and a small worsening in executive function.

61 euroanatomical alterations in mild cognitive impairment and Alzheimer's disease that can complement e

62 Contemporary data for causes of vision impairment and blindness form an important basis of reco

63 pulation-based data for the causes of vision impairment and blindness from 1980 to 2014.

64 keratitis is a major global cause of visual impairment and blindness, often affecting marginalized p

65 complication and its potential for severe VA impairment and blindness.

66 -intensity pulsed (LIP) ultrasound on memory impairment and central nervous system injury in a rat mo

67 independent of measures of anxiety or motor impairment and could be overcome by strong motivational

68 ng were pooled separately for mild cognitive impairment and dementia trials.

69 cation, and change in scores on the physical-impairment and everyday-activities domains of the Migrai

70 y, of which 13 had severe neurodevelopmental impairment and four died in early childhood.

71 We examined functional impairment and impairment in activities of daily living

72 naling cascade, culminating with contraction impairment and myofibril disruption in cardiomyocytes.

73 velop cognitive abnormalities, i.e. learning impairment and nesting behaviors based on passive avoida

74 s are not safe in patients with severe renal impairment and patients on dialysis.

75 human brain tissue correlated with cognitive impairment and reductions in synapsin expression.

76 CI, 26% to 30%) recovered from their initial impairment and remained independent throughout this peri

77 retinal disease is a common cause of visual impairment and represents a highly heterogeneous group o

78 he light of a strong linkage between the DDR impairment and the occurrence of common human diseases s

79 city, correlate with measures of behavioural impairment and the segregation of resting-state networks

80 ins of S. aureus) inducing barrier integrity impairment and tight junction damage.

81 he association between global neurocognitive impairment and visual field variability in patients diag

82 le and female) displayed mild spatial memory impairments and disrupted cingulate network connectivity

83 in ASD that considers both the individual's impairments and the biases of potential social partners.

84 y controls, 197 patients with mild cognitive impairment, and 180 patients with AD with dementia, plas

85 To describe the ocular findings, visual impairment, and association of structural complications

86 ssion critically drives Abeta-induced memory impairment, and strategies aimed at reducing Ephexin5 le

87 are independently associated with cognitive impairment, and that these lesions are likely to cause d

88 ysfunction, sleep disturbance, and cognitive impairment-and analysed all remaining AEs grouped by sys

89 These radiation-induced cognitive impairments are accompanied by functional and structural

90 Dendritic spine and synapse impairments are features of many neurological disorders,

91 son's disease and impulse control disorders, impairments are observed across subtypes of decisional i

92 highlight the notion that glucose metabolic impairments arising from disrupted NAc D2R signaling are

93 roponin identified fewer patients with renal impairment as low risk and more as high risk, but with l

94 tation identified 17% of patients with renal impairment as low risk for the primary outcome (negative

95 hinning disorder that leads to severe vision impairment As opposed to corneal transplantation; cornea

96 ing were associated with increased cognitive impairment, as assessed by Mini-Mental State Examination

97 th neonatal onset epilepsy and developmental impairment, as well as generalized and focal seizures an

98 sensus Cognitive Battery (MCCB) in cognitive impairment associated with schizophrenia and to examine

99 that may contribute to epilepsy or cognitive impairments associated with lissencephaly.

100 Serious respiratory morbidity, neurosensory impairment at 18 to 21 months of age, and a composite ou

101 inson's disease, the occurrence of cognitive impairment at 2 year follow-up can be predicted with goo

102 r early detection and the improvement of the impairment before the initiation of therapy.

103 the risk of visual impairment/severe visual impairment/blindness by 1.75 times (95% CI, 1.03-2.98) d

104 ined rate of academic, motor, and behavioral impairments but was associated with a reduced risk of mo

105 sign, not only for the presence of cognitive impairment, but also for cerebral small vessel disease (

106 Unexpectedly, respiratory impairment by mdivi-1 occurs without mitochondrial elong

107 In the CNS, mild cognitive impairment can be attributed to obesity-induced alterati

108 seases, the degree of coronary microvascular impairment carries important prognostic relevance.

109 majority of amyloid positive mild cognitive impairment cases, its cortical distribution overlapping

110 eptible to the progression of neurocognitive impairment caused by ageing in individuals with HIV.

111 KCalpha, reverses diabetes-induced autophagy impairment, cellular organelle stress and apoptosis, lea

112 ency in the mouse generated severe cognitive impairments, characterized by both a high occurrence of

113 % in microglial activation in mild cognitive impairment cohort over 14 months, which was associated w

114 lular mechanism for the attention and memory impairments comorbid with chronic pain.

115 were more likely to report subjective memory impairment compared to those without TBI even after adju

116 had an increased hazard for global cognitive impairment compared with those in the lowest quartile (h

117 nd function contribute to age-related memory impairment, complementing findings in the rodent and hum

118 iolipin stabilization reverted the energetic impairment, confirming the initial mitochondrial role.

119 on the Wide Range Achievement Test-4), motor impairment (defined as a percentile rank of </=5 on the

120 a prediction algorithm for global cognitive impairment (defined as Mini Mental State Examination [MM

121 the proportion of moderate or severe vision impairment (defined as presenting visual acuity of <6/18

122 The primary outcome was neurosensory impairment, defined as poor performance in one or more d

123 res of schizophrenia, such as working memory impairments, depend on distributed neural circuitry incl

124 titution Test (DSST) score and relative DSST impairment (DSST score </=28, lowest quartile in study c

125 Intravitreal Aflibercept Injection in Vision Impairment Due to DME)-in a multicenter setting.

126 abilization criteria in patients with visual impairment due to macular edema secondary to branch reti

127 with a history of TBI, 2 with mild cognitive impairment due to suspected Alzheimer disease) underwent

128 were independently associated with cognitive impairment during and after hospitalization.

129 is the first study to identify computational impairments during decision making in generalized anxiet

130 tiple viewpoints, and has revealed selective impairments during scene discrimination following hippoc

131 doptees and the adult remission of cognitive impairment, extended early deprivation was associated wi

132 robands affected by severe specific language impairment, followed by independent validations with San

133 d social participation may prevent cognitive impairment following natural disaster.

134 CVAQC), (2) VR QoL with the Impact of Vision Impairment for Children (IVI-C), and (3) HR QoL with the

135 Proteasome impairment has been detected in cardiomyopathies, heart

136 ntral clinical issue for RDEB, wound healing impairment has been only marginally investigated.

137 ent for listeners with sensorineural hearing impairment (HI).

138 ratio [HR] = 0.57, p < 0.05; mild cognitive impairment: HR = 0.19, p < .01), indicating that normal

139 ognitive, social, behavioural, and emotional impairments, implicated as antecedents to schizophrenia

140 was associated with a reduced risk of motor impairment in 11-year-old children with very low birth w

141 uctural complications of uveitis with visual impairment in a cohort of survivors of Ebola virus disea

142 We examined functional impairment and impairment in activities of daily living (ADL) (defined

143 tely leading to neurodegeneration and memory impairment in AD.

144 and WPAI-AS (Work Productivity and Activity Impairment in allergy) in 1288 users in 18 countries.

145 Memory impairment in Alzheimer's disease is a manifestation of

146 ted in a region-specific manner to cognitive impairment in Alzheimer's disease.

147 ace Flight Induced Ocular Changes and Visual Impairment in Astronauts" by Alperin et al This article

148 follow-up neurocognitive testing had severe impairment in at least 1 neurocognitive domain at the mo

149 sed the lysosomal dysfunction, relieving the impairment in autophagic flux and further stimulated aut

150 ventricular cardiac dysfunction and vascular impairment in baboons who were IUGR at birth because of

151 understanding of the basis for intellectual impairment in Down syndrome is hindered by the large num

152 at such defects may contribute to functional impairment in DS, and that these phenotypes, present in

153 t neuroinflammation and subsequent cognitive impairment in HIV-positive patients.

154 mRFP) reporter mice and transgenic mice with impairment in IL-10 receptor signaling were used to test

155 eases and in the development of symptoms and impairment in individual patients.

156 pyramidal cells, and we observed a profound impairment in mGlu3-LTD following a single, 20-min restr

157 The results suggest an impairment in mitochondrial pyruvate metabolism, resulti

158 c and molecular bases for neurodevelopmental impairment in model mice in vivoSIGNIFICANCE STATEMENT O

159 alpha-synuclein have been linked to neuronal impairment in Parkinson's disease and related neurodegen

160 osis (MS) to explore their impact on balance impairment in patients with MS, considering the role of

161 retinal blood vessels commonly causes vision impairment in proliferative retinopathies, including ret

162 to date the long-term trajectories of social impairment in psychotic disorders have rarely been studi

163 oL) in allergic rhinitis (AR), the degree of impairment in QoL in nonallergic rhinitis (NAR) remained

164 common pathological mechanism leading to PVI impairment in schizophrenia and some forms of autism.

165 sive infections are associated with a severe impairment in SIV-specific antibody production.

166 ed to confer some protection against hearing impairment in some older adults warrants replication in

167 report, for the first time, a nerve terminal impairment in SV trafficking selectively in MB neurons b

168 xploring the genetic and molecular basis for impairment in the disease.

169 Impairment in Theory of Mind (ToM), the ability to infer

170 igh-frequency stimulation trains suggests an impairment in vesicle mobilization.

171 ively, our results illustrate that cognitive impairment in zebrafish could be associated with Se-indu

172 aused lasting attentional dysfunction due to impairments in attentional preparedness, selective atten

173 oligophrenin-1 is associated with cognitive impairments in both human and mouse.

174 n Tpl2(-/-) mice are not caused primarily by impairments in CD4 T cell function but result from defec

175 Impairments in certain cognitive processes (e.g., workin

176 sed to childhood victimization had pervasive impairments in clinically relevant cognitive functions,

177 Kmo(-/-) mice exhibited impairments in contextual memory and spent less time tha

178 with inflammatory bowel disease (IBD) report impairments in daily activities, social interactions and

179 Accumulating evidence suggests that impairments in early brain development caused by trisomy

180 ively, domain-specific accounts suggest that impairments in face and word processing need not go hand

181 ing in higher toxicity in cells, and severer impairments in locomotion, egg-laying, and survival in C

182 a expression, and, most notably, age-related impairments in mitochondrial biogenesis and mitochondria

183 euron and circuit and which is vulnerable to impairments in neuropsychiatric disorders.

184 ain injury (B-TBI) induced lasting cognitive impairments in novel object recognition and less severe

185 Impairments in object recognition, spatial memory retent

186 it underpinnings that may underlie cognitive impairments in offspring of mothers that abuse marijuana

187 We found impairments in oxidative phosphorylation and changes in

188 isruption of the left angular gyrus leads to impairments in simulation and memory.

189 to how Abeta and tau interdependently cause impairments in synaptic function in AD.

190 in a significant increase in body weight and impairments in their working memory together with decrea

191 ia spectrum disorders, have been linked with impairments in Theory of Mind (ToM).

192 pment of interventions that target cognitive impairments in this chronic and debilitating mental illn

193 most common inheritable form of intellectual impairment, including autism.

194 ndition that involves renal microcirculation impairment, infiltration of inflammatory cells with loca

195 r lymphoid differentiation of HSPCs, and its impairment is a key mechanism underpinning the lymphopen

196 This threat memory impairment is also reflected in increased behavioural su

197 cells suggests that hippocampal neurogenesis impairment is an important factor underlying these cogni

198 ANGPT1 impairment is associated with angioedema, and ANGPT1 var

199 Data are inconclusive as to whether this impairment is attributable to surgery and anesthesia exp

200 ons to ageing-induced atrophy and functional impairment is still unsettled.

201 Neurodevelopmental impairment is the most common comorbidity associated wit

202 Purpose Cognitive impairment is well-recognized after myeloablative alloge

203 A- and b-waves showed progressive impairment later from 2 and 3 months of age onwards, res

204 ongenital infection that can cause long-term impairment (LTI).

205 n included: caring for people with cognitive impairment; managing the emotions of patients, families

206 out appropriate medical intervention, visual impairment may become a great burden to our healthcare s

207 /macrophages of patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) are defectiv

208 h high risk of progression to mild cognitive impairment (MCI) or AD.

209 l marker for progression from mild cognitive impairment (MCI) to dementia.

210 opic imaging in subjects with mild cognitive impairment (MCI), patients with Parkinson disease (PD),

211 ults with normal cognition or mild cognitive impairment (MCI).

212 Male reproductive impairment might result from factors that affect sperm p

213 eceiving treatments were evaluated for motor impairment, mortality, and spinal cord viral load.

214 naptic activity is associated with cognitive impairment observed in a number of psychiatric and neuro

215 son for diagnostic exclusion was symptoms or impairment occurring exclusively in the context of heavy

216 ses revealed that the age-related myocardial impairment occurs in parallel with shifts in the composi

217 Compared with controls, patients reported impairment of all aspects of fecal control (P < 0.05), e

218 of place cell firing appears to indicate an impairment of attentional processes.

219 estasis is a clinical disorder defined as an impairment of bile flow, and that leads to toxic bile ac

220 on and suggest that, in Alzheimer's disease, impairment of brain insulin signaling might occur via ta

221 s C virus (HCV) infection is associated with impairment of cognitive function and mood disorders.

222 Depending on the specific impairment of each participant, we modified the interfac

223 the essential process of translation through impairment of EF-Tu function.

224 ng prion permissive cells, we determined how impairment of endocytosis affects productive infection b

225 ress alters CA1 circuit function through the impairment of endogenous NPY release, potentially contri

226 d vascular/endothelial ER stress, associated impairment of endothelium-dependent vasorelaxation, and

227 However, the impairment of estrogenic relaxation was evident after th

228 Compared with matched peers, significant impairment of fecal control prevails after TEPT in HD pa

229 Ablation or functional impairment of Foxp3(+) Tregs in vivo at the start or sto

230 al glomerular filtration barrier, results in impairment of glomerular permselectivity.

231 the same animal model, whether the reported impairment of HDL cardioprotective function was associat

232 Impairment of host colonization using antibiotics also c

233 The impairment of HR by HPV oncogenes may be targeted for tr

234 We found that impairment of humoral immunity was most outspoken in the

235 and Akkermansia, which also involved in the impairment of intestinal barrier after FMT.

236 at (tam)Arl13b(-/-) basal bodies, suggesting impairment of intraflagellar transport.

237 nce that persistent immune activation causes impairment of lymphocytes to respond to chemotactic stim

238 onal changes in lysosomal pH, which leads to impairment of lysosomal enzyme activity and disruption o

239 hylester (Mg-proto MME), consistent with the impairment of Mg-proto MME cyclase activity.

240 the lack of recovery from metformin-induced impairment of mitochondrial energy metabolism (glucose o

241 ative stress and significant ultrastructural impairment of mitochondrial morphology with a loss of in

242 Thus, impairment of parasite maturation represents a host-medi

243 decrease in MGDG In NgDelta0-elo1 lines, the impairment of photosynthesis is consistent with a role o

244 eloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs.

245 In contrast to the well-known significant impairment of quality of life (QoL) in allergic rhinitis

246 tor CXCR3, which correlated with significant impairment of renal Treg infiltration.

247 fibres went through significant atrophy and impairment of specific force (isometric force/cross-sect

248 Disruption of the pathway resulted in an impairment of specifically noise-cued fear conditioning.

249 xpression of APP and that the Abeta-mediated impairment of synaptic plasticity is accompanied by pres

250 nc-104's function is disrupted, and leads to impairment of synaptic structure and function by restrai

251 associated with LV concentric remodeling and impairment of systolic and diastolic function parameters

252 ke and insulin resistance (IR) to functional impairment of the heart.

253 f aged donor hepatocytes or the regenerative impairment of the recipient livers.

254 Our study provides genetic evidence that impairment of trophoblast-specific GATA2/GATA3 function

255 RAGE-knockout mice displayed striking impairment of tumor cell growth compared with wild-type

256 od revealed high concentrations and suggests impairment of water quality, particularly since 2011.

257 6 stabilized its substrate AXIN1, leading to impairment of WNT3a-induced beta-catenin activation and

258 In children, impairments of cognitive function are important manifest

259 These results provide evidence that impairments of the fundamental cellular processes, like

260 greater rates of cognitive decline (greater impairment on the 11-item Alzheimer's Disease Assessment

261 s of CCT in older adults with mild cognitive impairment or dementia.

262 its occur before the onset of mild cognitive impairment or dementia.

263 titis: OR 1.30; depression: OR 1.47; hearing impairment: OR 1.91) (all P < .05).

264 99.9%), in comparison with 56% without renal impairment (P<0.001) with similar performance (negative

265 bit mild cerebellar foliation defects, motor impairments, partial pontine nucleus migration defects,

266 Secondary outcomes were level of impairment, physical and social functioning, psychologic

267 r-smokers without obstruction or respiratory impairment, PRM(FSA) increased 2.7% per decade, ranging

268 The observed impairments proved to be decisive in vivo because silenc

269 e best correlation with the later functional impairment (R(2) =0.94).

270 is frequently associated with communicative impairment, regardless of intelligence level or mental a

271 did not have increased risk of neurosensory impairment (risk difference [RD], 0.01; 95% CI, -0.07 to

272 the ELM, and significant macular functional impairment (RS decrease) vs SND-.

273 level 4, American Spinal Injury Association Impairment Scale category A).

274 gnosed as having MCI or subjective cognitive impairment (SCI).

275 Physical-impairment scores improved by 4.2 and 4.8 points in the

276 s (95% CI, 1.01-1.43) and the risk of visual impairment/severe visual impairment/blindness by 1.75 ti

277 ctors for osteonecrosis of the jaw and renal impairment should be assessed, and any pending dental or

278 ND reporting the most severe physical health impairments showed reduced left anterior insular volume

279 n underlying mechanism of age-related memory impairment.SIGNIFICANCE STATEMENT Alterations in episodi

280 teacher, and self-reports of ADHD symptoms, impairment, substance use, and other mental disorders, w

281 thy-causing mutations may lead to proteasome impairment, such as altered calcium handling and increas

282 such as addiction, psychosis, and cognitive impairment) than cannabis with lower concentrations of T

283 egeneration (AMD) is a major cause of visual impairment that affects the central retina.

284 nied by cognitive problems, including memory impairments that contribute to poor quality of life.

285 h low testosterone and age-associated memory impairment, treatment with testosterone for 1 year compa

286 rade facilitation and alcohol induced memory impairment using two independent tasks.

287 ciation of measured and self-reported visual impairment (VI) with cognition in older US adults.

288 Functional impairment was a composite of poor academic performance

289 During 24569 person-years, mild cognitive impairment was diagnosed in 104 (5.1%) individuals, and

290 This impairment was more profound in naive B cells from CVID

291 ression, however, risk for subjective memory impairment was no longer significant (RR [95% CI]: 1.18

292 Consistent with these impairments, we observed addictive-like behavior in DIO-

293 l activity, and obesity), people with vision impairment were more likely than those without to report

294 e; those with subcortical vascular cognitive impairment were more likely to have hypertension, diabet

295 .8 years]), the combined rates of functional impairment were not significantly different between the

296 Too few cases of cognitive impairment were reported for a statistically reliable an

297 ity, psychiatric symptom severity, and sleep impairment were significantly worse in patients with con

298 e with Alzheimer's disease-related cognitive impairment were younger, more likely to have a positive

299 rch has shown that this can lead to specific impairments when transcoding numerals from dictation to

300 vtx/vtx mutant mice exhibit profound hearing impairment, which is associated with enlarged endolympha