ライフサイエンスコーパス: impede

1 tter inputs decay, and forest growth remains impeded.

2 As such, viral replication is impeded.

3 However, overexpression of TIRR impedes 53BP1 function by blocking its localization to d

4 hat limit the performance of AR research and impede accelerated, intensive development of AR-focused

5 out-of-pocket costs of PCSK9 inhibitors may impede access and reduce long-term adherence.

6 tures surrounding the RBS pocket in MACV GP1 impede access of JUNV-elicited antibodies.

7 ional review and revision of provisions that impede access to opioids, disproportionate to their (int

8 expression of the subset repressor IRF8, and impedes access of JunD to regulatory regions of alternat

9 jacent 5'TOP motif of TOP mRNAs, effectively impeding access of eIF4E to the cap and preventing eIF4F

10 necessary ingredients, while simultaneously impeding access.

11 migration and proliferation, resulting from impeded actin dynamics, cell spreading, and cell cycle a

12 y that replication fork progression might be impeded, adding to increased genomic instability and con

13 at can be quantified in single cells in situ impede advances in our deep understanding of normal cell

14 Moreover, Arid1a deletion impedes AHR expression and impairs the maintenance of NK

15 Loss of this subunit impedes alkylation adduct repair kinetics and increases

16 d optical absorption of several biomolecules impedes an effective in vivo pH imaging in tumors.

17 ver, the cellular heterogeneity of the brain impedes an understanding of how MECP2 mutations contribu

18 he lack of long-term instrumental data often impede analyses attempting to associate changes in land

19 expectations, social life will be seriously impeded and, in turn, expectations leading to satisfacto

20 cell-to-cell transmission, was significantly impeded as shown by green fluorescent protein (ie, infec

21 ed as an isolated intracranial thrombus that impedes ascending blood flow) in the context of acute st

22 r to the target sequence could substantially impede association of the transcription factor Egr-1 wit

23 ng to specially engineered quantum dots with impeded Auger decay, we demonstrate a considerable reduc

24 Functional status declines with aging, thus impeding autonomy.

25 Second, CYCLO impeded autophagosome-lysosome fusion as evidenced by th

26 that knockdown of Kv3.4 by a specific shRNA impedes axon initiation, elongation, pathfinding, and fa

27 Vimentin interacts with Jagged, impedes basal recycling endocytosis of ligands, but is r

28 sisted for 40 years, and improvements may be impeded based on the current public reporting of overall

29 or SmCalp2 perform this cleavage function to impede blood clot formation around the worms in vivo.

30 perfusion of Egfl7(-/-) placentas marked by impeded blood conductance through sites of narrowed vess

31 targeting of UBAP1 and TLR adaptors by PumA impedes both cytokine and TLR receptor signalling, highl

32 fecting the architecture of the translocase, impedes both protein and tRNA import.

33 , Gpr132 deletion reduces M2 macrophages and impedes breast cancer lung metastasis in mice.

34 ffect is still far from understood, which is impeded by a lack of clarity on their structures.

35 eries for grid-scale energy storage has been impeded by a lack of electrolytes that undergo redox eve

36 ellular and behavioural phenotypes have been impeded by a lack of experimental tools.

37 f melt generation in rifting environments is impeded by a paucity of direct observations of mantle me

38 nt of all TFs, including pioneer factors, is impeded by condensed H3K27me3-containing chromatin.

39 ns revealed that dermal invasion is directly impeded by dermal fibroblasts.

40 nd understanding of multimodal HSI have been impeded by difficulties in registration of the different

41 iplex-formation, and that dsDNA extension is impeded by formation of RNA secondary structure in the i

42 protected amines, but its widespread use is impeded by safety issues (the need to handle azides).

43 es using ion mobility spectrometry (IMS) was impeded by small collision cross section differences (co

44 sting that intracellular activities are less impeded by smaller engineered insertions.

45 However, progress in such systems is impeded by the inability to access more than a fraction

46 who are frequently exposed to infections is impeded by the inflammatory response, which causes iron-

47 Such efforts are impeded by the lack of a physiologically relevant, pre-c

48 ature of this Mott insulating phase has been impeded by the lack of knowledge about the low-energy el

49 to develop anti-prion therapeutics have been impeded by the lack of screening models that faithfully

50 studies on perovskite thin-film devices are impeded by the morphological and compositional heterogen

51 , clinical application of cytokines is still impeded by their multiple toxic side effects.

52 e show that small molecule inhibitors of UGM impede C. glutamicum growth, suggesting that the galacta

53 e, neuropathy-associated KIF1Bbeta mutations impede cargo transport, providing a direct link between

54 ve markers for MOB interneurons has strongly impeded cell-type-selective investigation of interneuron

55 weights, restores B-cell follicle formation, impedes cell cycle progression of pretumor B cells, and

56 at low oxidative concentrations of H2O2 also impede chemokinesis and chemotaxis of previously activat

57 AhR ligands induces Cyp1a1 but not Ccno and impeded ciliogenesis.

58 he time and cost of the approval process may impede clinical translation.

59 nce of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcri

60 actose and siallylactose that are thought to impede colonisation by pathogens and encourage an approp

61 assifications, and the incurred consequences impede communication among researchers.

62 d protocols and common analytical frameworks impedes comparisons among studies, hindering the develop

63 cancer treatment, because it is critical to impede compensatory signaling mechanisms that can engend

64 e Mo layer likely hinders O2 gas permeation, impeding contact with active Pt.

65 ergy acquisition is sedimentation because it impedes coral heterotrophic feeding and their ability to

66 6) in vivo increases PD-L1 protein levels by impeding cyclin D-CDK4-mediated phosphorylation of speck

67 ous H2 at concentrations exceeding 3000 ppmv impeded DCM degradation.

68 heir structure remains poorly defined, which impedes detailed study of their gating and ion permeatio

69 uickly to invasive growth of a pathogen, can impede development of F. oxysporum.

70 stinguish malignant from benign tissue, both impeding diagnosis of early and metastatic cancer stages

71 6 mediate the down-regulation of BMI1, which impedes DNA repair while elevated levels can sensitize b

72 fically interfered with this interaction and impeded DnaB function in DNA replication, but not its ac

73 ed, with many gaps, ambiguities, and errors, impeding downstream applications.

74 resulting condensed, highly crosslinked ECM impeded drug permeation, protecting tumor cells from exp

75 and discusses progress toward and challenges impeding drug development for inhibiting or evading P-gp

76 ts-promoted acetylation of lys(101) of ECHS1 impedes ECHS1 activity by impairing enoyl-CoA binding, p

77 periphery of tidal marshes can facilitate or impede ecosystem migration in response to rising sea lev

78 asing concentration of octanol increased the impeding effect, but only up to 10-20 mol %.

79 Low affinity of IL-10Rbeta for cytokines has impeded efforts aimed at crystallizing cytokine-receptor

80 g and its effect on thermal conductivity has impeded efforts to improve the thermoelectric figure of

81 l complexity it manifests upon ingestion has impeded efforts to unambiguously identify the specific s

82 eir low-temperature properties are distinct, impeding efforts to understand the phenomena within a si

83 vious studies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAPII).

84 ensin silencing in AMPK-depleted fibroblasts impedes enhanced cell spreading, traction stress, and fi

85 Our results illuminate how PR may indirectly impede ER action by reducing the bioavailability of tran

86 O. tsutsugamushi also impedes ERAD during this time period.

87 ablished fibrosis in a chronic DSS model and impeded ex vivo pro-fibrotic protein secretion from sten

88 restrain mouse haESCs from diploidization by impeding exit from naive pluripotency and by shortening

89 letion of the F1L N-terminal region does not impede F1L antiapoptotic activity in the context of a vi

90 Enabling and impeding factors were thematically analysed.

91 care professionals and identify enabling and impeding factors.

92 anding of plant responses to extreme drought impedes forecasts of both forest and crop productivity u

93 the disordered formin homology 1 domain and impede formin-mediated actin filament elongation.

94 ed, is known to activate the p53 pathway and impede full-length MDM2's negative regulation of p53.

95 ion for these findings is that preterm birth impedes function of the cerebellum even in the absence o

96 tion of immune cells into adipose depots and impede further angiogenesis.

97 to the channel's entry port, where they can impede further translocation.

98 bending the semiconductor bands, and finally impeding further charge transfer.

99 connected by suitable habitat that does not impede gene flow.

100 se proteins, including RBMX and RBMXL1, that impede gene induction during cellular reprogramming.

101 g normal B-cell differentiation programs and impeding germinal center exit.

102 S409A, the Neto2 S409D phosphomimetic mutant impeded GluK1 trafficking to synapses.

103 ied by lesions of the contralateral amygdala impede goal-directed response selection, implicating BDN

104 o gain insight into why loss of hda function impedes growth.

105 of capsid-host interactions that promote or impede HIV-1 infection may provide unique insight to exp

106 e 3G (A3G) is a host restriction factor that impedes HIV-1 replication.

107 us and found that calcium chelation severely impedes hyphal growth indicating a critical requirement

108 phosphorylation in endothelial cells, which impedes ICAM-1 clustering in response to HLA class I Ab

109 Na(+) access to the droplet surface, thereby impeding IEM ejection.

110 med at discovering small-molecule inhibitors impeding IL-15/IL-15R interaction.

111 This sustained signaling may impede immune recovery and foster viral persistence.

112 ures, they inhibited B-cell differentiation, impeded immunoglobulin secretions, and expanded Foxp3(+)

113 High vaccine costs, however, impede implementation in endemic countries.

114 focus on identifying and modifying barriers impeding improved glycemic control in black persons with

115 our understanding of mosquito behaviour that impede innovation.

116 chelation can promote gastric stability and impede intestinal release, for peptides intended for use

117 patients and culture-based infection models impedes investigation of the underlying factors contribu

118 th local changes in polymer packing that may impede ion transport to different extents within the sam

119 hub for activation of the MAPK pathway, and impedes IQGAP1-dependent phosphorylation of ERK1/2 (pERK

120 Here, we report that this phosphorylation impedes ITCH binding to its cognate E2 ubiquitin ligase,

121 ts with2-aminoimidazole based compounds that impede its function.

122 rGMPs are expected to distort the mtDNA and impede its replication, and elevated rGMP incorporation

123 Persistent Vangl2 stabilizes Celsr1 and impedes its internalization, suggesting that dissociatio

124 rimental challenge for most materials, which impedes its wide recognition.

125 loprotease zinc-containing active site, thus impeding its proteolysis of the endogenous protein subst

126 down of YTHDF2 enhanced lytic replication by impeding KSHV RNA degradation.

127 xpression of SIRT1 during IL-1beta challenge impeded LEF1 levels and MMP13 gene expression.

128 er cultures, but further development appears impeded, likely because of lack of a lineage-stabilizing

129 ensitivity to ischemia reperfusion (I/R) and impedes liver regeneration (LR).

130 binding of the host replicative helicase but impeding loader self-assembly and ATPase activity.

131 pound whose entry requires endocytosis), and impedes Lucifer yellow uptake (a marker of fluid phase e

132 es were immediately toxic to hair cells, and impeding lysosome delivery increased AG-induced death.

133 n SR-AI-deficient Mvarphi cell line revealed impeded M2 polarization and decreased phagocytic capacit

134 Mutations within POLG impede maintenance of mtDNA and cause mitochondrial dise

135 have shown that a deletion of laminin alpha2 impedes male fertility by disrupting ectoplasmic special

136 Fgf20 deficiency does not impede mammary gland induction, but compromises mammary

137 rmacological Gpr132 inhibition significantly impedes mammary tumor malignancy.

138 se changes tend to benefit a few species but impede many, the expected outcome is generally decreasin

139 anied by a loss of haploid spermatids due to impeded meiosis.

140 mpLA and EspP creates an energy barrier that impedes membrane insertion.

141 nse to weak co-evolutionary interactions and impede migration in the opposite direction, as a result

142 Targeting wild-type MLL degradation impedes MLL leukemia cell proliferation, and it downregu

143 gnaling to MuSCs during recovery from injury impedes muscle repair and strength.

144 itors from NFI-A myeloid cell-deficient mice impeded myeloid cell maturation and promoted immune repr

145 suggest that mutated desmin already markedly impedes myocyte structure and function at pre-symptomati

146 tinase enzyme, STAM-binding protein (STAMBP) impedes NALP7 trafficking to lysosomes to increase NALP7

147 The complexity of the lignin structure also impedes necessary and decisive information to understand

148 ated fatty acids have recently been shown to impede NLRP3 activity.

149 y to elicit efficient gene knockdown without impeding normal cellular function.

150 tic pathway, and enters the nucleus where it impedes nucleosome assembly.

151 in late-stage clinical development and might impede oncogenic signaling from mutant RAC1.

152 of clarity regarding prediction quality have impeded optimal use.

153 There are however unresolved physics issues impeding optimal implementation, including estimation of

154 proved neutrophil migratory accuracy without impeding other neutrophil functions in a double-blind ra

155 Numerous challenges impede our progress: patient phenotypes may not match kn

156 cificity of Human Cytomegalovirus (HCMV) has impeded our understanding of antiviral adaptive immune r

157 rential processing are unknown, and this has impeded our understanding of the dysregulation of oncomi

158 Next, we explore factors that have impeded our understanding of the GC and Tfh-cell process

159 tments are regularly isolated in the clinic, impeding our ability to control infections.

160 ng its larval growth phase has been limited, impeding our ability to understand how morphogen pattern

161 r cell biology remains poorly characterized, impeding our understanding of how basal processes and en

162 ocal density of key centriolar precursors to impede overduplication.

163 GAT211 did not impede paclitaxel-induced tumor cell line toxicity.

164 production cost of mammalian cell expression impedes patient access to such treatments.

165 sphorylation of Thr(6) or Tyr(8) on UNG2 can impede PCNA binding without affecting UNG2 catalytic act

166 nished descending sensory prediction signals impede perceptual learning and may, therefore, underpin

167 Mutations that impede phase separation reduce organism fitness during p

168 -like autophagy-activating kinase1 (Ulk1) by impeding phosphorylation of, and thus inactivating, a ne

169 generating nuclear data for polyploids have impeded phylogenetic study of these groups.

170 on of A kinase-anchoring protein 12 (AKAP12) impeded platinum adduct clearance and prevented cAMP-med

171 This lack of clarity may be impeding policy action.

172 matal conductance among cultivars apparently impedes positive scaling between mesophyll conductance a

173 Cellular heterogeneity impedes precise understanding of the molecular component

174 that the non-lethal risk cues differentially impeded prey reproductive success that varied by clone,

175 ceptors (NMDARs) within cortical circuits to impede processing and to promote aggression.

176 proves the efficiency of iPSC generation and impedes processing of miR-125b, leading to Rybp upregula

177 rge number of SVOC/surface combinations have impeded progress in understanding sorption of SVOCs on i

178 eplication challenges are present that could impede progression of the replication fork.

179 stimated population dynamics and potentially impeding projection of deterministic and stochastic popu

180 NF-kappaB pathway, retards inflammation and impedes proliferation at the early stages of regeneratio

181 RNA-mediated knockdown of FcRn in the cornea impeded protection against ocular HSV-1 challenge in vac

182 ls function in a critical temporal window to impede protective immunity through cytotoxic-T-lymphocyt

183 (+)Foxp3(+) regulatory T cells (T reg cells) impedes protective responses, resulting in chronic infec

184 nt member of the unique alpha-kinase family, impedes protein synthesis by phosphorylating eEF-2.

185 ciated enzymes that help resolve replication-impeding R-loops.

186 AD51, sequesters RAD51 in the cytoplasm, and impedes RAD51 binding to DNA.

187 n of TGF-beta, BMP, or Wnt pathways does not impede reactionary dentine formation, although inhibitio

188 A main challenge that significantly impedes REBa2Cu3Ox (RE = rare earth) coated conductor ap

189 in significant skeletal muscle cachexia that impedes recovery.

190 Providing income supports without impeding recovery remains an important policy challenge.

191 D)-induced remodeling to identify mechanisms impeding recovery.

192 in highly variable, as observed in patients, impeding reliable one-dimensional association with phase

193 odendrocyte progenitor cells (OPCs), thereby impeding remyelination, in the demyelinating disease mul

194 events formation of structural barriers that impede replication at fragile regions in the genome.

195 are stable DNA structures that are known to impede replication fork progression.

196 Here, we demonstrate that impeding replication by small-molecule-mediated stabiliz

197 interfere with DNA replication by slowing or impeding replication fork progression.

198 n this emerging group, and multiple barriers impede research in adult CHD.

199 Inconsistency in trial outcomes may impede research synthesis and indicates the need for dis

200 of data-sharing practices that unnecessarily impede research.

201 lability has been limited and variable, thus impeding research and clinical studies.

202 s of participants and poor trial recruitment impeding research.

203 rtship behaviour of treated couples was also impeded resulting in a reduction of mating rates by up t

204 lix inside a hydrophobic crevice of NCS-1 to impede Ric8a interaction.

205 ncing upper plate-motion setting can locally impede rollback and maintain flat slabs until slab teari

206 Restoration of miR-874 expression impeded S phase progression, suppressing aggressive grow

207 P reduces initial mosquito infection by 50%, impedes salivary gland invasion 10-fold, and causes a co

208 ng destruction complex activity, but also by impeding signalosome assembly.

209 Here, we have shown that oil impeded snail movement to clean habitat over a short dis

210 stals-50 unit cells per edge, on average-has impeded structural characterization by conventional mean

211 The lack of small-animal models has impeded studies of antiviral immune mechanisms.

212 the precise mechanisms whereby HIV infection impedes successful T cell-mediated control of M. tubercu

213 g, how pharmacological agents may promote or impede such signalling and the pathogenic effects of gan

214 identify legal and regulatory barriers that impede telehealth adoption or delivery, propose steps to

215 te to accelerate the [4+2] cycloaddition and impede the [6+4] cycloaddition through interactions with

216 to a complex response that could improve or impede the anti-tumour effect of serine and glycine star

217 al representation of the previous task might impede the buildup of a neural task representation.

218 e uncovered that ER stress responses further impede the development of protective anti-cancer immunit

219 adaptations to therapeutic pressure by BTICs impede the discovery of effective anti-BTIC therapies an

220 barriers protect against pathogens but also impede the establishment of essential symbiotic partners

221 options and discuss promising strategies to impede the evolution of drug resistance.

222 Structural barriers impede the optimal delivery of clinical care for prisone

223 complex etiology of the condition have long impeded the advancement of the development of pharmacolo

224 porcine endogenous retroviruses (PERVs) has impeded the clinical application of this approach.

225 e, SASPs, and activation of Stat3 as well as impeded the development of fibrosis.

226 strain and after several washing cycles has impeded the fabrication of electronic devices on textile

227 The S4-S5 linker mutation, G546L, impeded the faster phase of voltage sensor stabilization

228 nce targets for commensal E. coli Mucin gels impeded the motility of E. coli by acting as a physical

229 mentation, and resource limitations may have impeded the potential impact of CHWs for achieving HIV g

230 L, the best-known molecular target of ABHD5, impeded the proliferation and invasion, suggesting an AT

231 s in relating sound levels to abundance have impeded the use of passive acoustics to conduct quantita

232 ing density separation, the organic fraction impedes the ability to conduct reliable analyses.

233 tary metal-oxide-semiconductor architectures impedes the achievement of three-dimensional interconnec

234 impacts Ca(2+) release from the lysosome and impedes the activity of specific lysosomal enzymes indic

235 gand complex structures with diverse ligands impedes the application of structure-based drug design (

236 es 112-150) in its coiled-coil 1 domain that impedes the binding of linear (M1-linked) di-ubiquitin t

237 o a significant decline in power density and impedes the commercialization of PRO technology.

238 ete repression causes expression leak, which impedes the construction of larger synthetic regulatory

239 The size and complexity of the Hsp90 system impedes the detailed investigation of their interplay us

240 ansient wake of heterosubtypic immunity that impedes the emergence of novel flu viruses.

241 scales, the ergodicity of the fast subsystem impedes the equilibration of the whole system because of

242 We observe that the presence of ssRNA impedes the extension of dsDNA, specifically at low forc

243 the human ClC-Kb channel in mammalian cells impedes the functional study of CLCNKB mutations, and th

244 ibitor, PX-12 (untested in prostate cancer), impedes the growth of CRPC cells to a greater extent tha

245 Similarly, elevated expression of GFI1 impedes the in vitro expansion of murine pre-leukemic ce

246 licates the predictability of outcome, which impedes the integration of acupuncture into mainstream p

247 buted to the TiBw architecture that severely impedes the movements of dislocation and grain boundary

248 ack of intuitive and integrative web servers impedes the progress of making effective use of emerging

249 netrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in

250 adult worms (macrofilariae) and temporarily impedes the release of such progeny by female macrofilar

251 Herein, we show that SIRT2 impedes the TPPP/p25-promoted microtubule assembly indep

252 xists, the scarcity of hominin fossils often impedes the understanding of which hominins occupied a s

253 is integral to cell identity maintenance by impeding the activation of genes for alternate cell fate

254 ly the development of psoriatic arthritis by impeding the Adam17-mediated release of TNF.

255 inary group of experts to discuss challenges impeding the conduct of HABP/VABP trials.

256 results suggest a new therapeutic target for impeding the development of DIC.

257 r work highlights critical HIV-2 RT residues impeding the development of excision-mediated NRTI resis

258 hat androgens cause these sex differences by impeding the LT-biosynthetic 5-LO/FLAP complex assembly.

259 ol inhibited mitophagy and autophagy through impeding the PI3K Class III/Belin-1 pathway.

260 the flavin through a nonproductive pathway, impeding the signaling efficiency.

261 are heterozygous for the orthologous factor, impeding the study of complex phenotypes and critically

262 zes the closed state of the channel, thereby impeding the transition into a conducting state.

263 ty, accuracy, and precision) are key drivers impeding the uptake of FDS by the majority of users.

264 reactions, and limited power output severely impede their practical applications.

265 of 3' untemplated addition, a mechanism that impedes their biogenesis, whereas TRC miRNAs appear to e

266 ly and have relatively low efficiency, which impedes their extensive use in developing countries.

267 expression in metastatic breast cancer cells impedes their metastatic colonization of the lungs of mi

268 ith mitochondrial quality control mechanisms impedes their roles in maintenance of lung health.

269 ly used MTGs have low substrate specificity, impeding their biotechnological use as enzymes that do n

270 uld negatively impact spirochete survival by impeding their swim speed, thereby enabling their captur

271 Enabling and impeding themes included: Teaching Approaches, Clinical/

272 man Brain Mapping and identify barriers that impede these practices, including how the discipline mus

273 rface contamination especially with biofilms impede this characterization.

274 ha7nAChR - ferroportin signaling pathway may impede this mechanism.

275 indings suggest that critical water deficits impeding tissue growth occurred at relatively high water

276 ition, lipid oxidation in treated muscle was impeded to some extent.

277 precise, medicine-based approach to directly impede transcription and overcome aberrant pathways in a

278 where they likely facilitate DNA bending and impede transcription bubble collapse.

279 TA box and transcription start sites did not impede transcription but rather, enhanced it: the level

280 the hypothesis that deactivated Cas9 enzyme impedes transcription across expanded microsatellites.

281 use site to positions further downstream but impedes transcription through the +1 nucleosome genome-w

282 B2 signaling can be activated in SCs but not impede transdifferentiation of denervated SCs to regener

283 whereas N2-methylguanosine (m2G) moderately impeded translation.

284 ization of the transcription factor IRF3 and impeded translocation of IRF3 to the nucleus after viral

285 tes a disruption in coral tissue that likely impedes translocation of energy within a colony.

286 Biopolymeric matrices can impede transport of nanoparticulates and pathogens by en

287 tion of lymphoid organ homing molecules, and impeded Treg cell homing to non-lymphoid organs, causing

288 Combined systemic distribution of AZA and RA impedes tumor growth and prolongs survival.

289 hat KLF4 dysregulation either facilitates or impedes tumor progression, making it important to clarif

290 verexpression slowed TRC growth in vitro and impeded tumorigenesis in vivo.

291 hat inhibition of IL6 signaling dramatically impedes tumorigenesis following partial hepatectomy with

292 Although IFNgamma can impede tumour growth by acting directly on cancer cells,

293 refore presents a therapeutic opportunity to impede tumour relapse.

294 ties in interrogating individual neurons has impeded understanding of the underlying transcriptional

295 over, the replacement of lithium metal anode impedes unwanted side reactions between the dissolved in

296 IFITM proteins impede viral entry, and ZMPSTE24 expression is necessary

297 ion and cause immunosuppressive effects that impede virus clearance.

298 GLI potentiates Tsix expression and impedes XCI.

299 The region responsible for impeding XRN1 includes a G-rich portion that likely form

300 e decay of m(6)A-modified maternal mRNAs and impedes zygotic genome activation.