ライフサイエンスコーパス: impediment

1 s passed through the initial segment without impediment.

2 s as well as previously thought due to mucus impediment.

3 are produced to provide instruction without impediment.

4 )3 kinase activity partially alleviates this impediment.

5 is simply neglected or calibrated for as an impediment.

6 Stat5 overexpression is able to bypass these impediments.

7 nanoparticles has been limited by technical impediments.

8 well as repriming replication downstream of impediments.

9 e Carnivorans may harbor comparatively fewer impediments.

10 operties and are perceived as insurmountable impediments.

11 e genome duplication in the presence of such impediments.

12 mpered by both computational and statistical impediments.

13 m of, but closely coupled to, G4 replication impediments.

14 ased catalysts has been limited by technical impediments.

15 g on the future strategies to surmount these impediments.

16 cargo-associated motor behaviour to react to impediments.

17 based metabolomics data by reducing existing impediments.

18 stance, and hyponatremia represent treatment impediments.

19 To overcome the first impediment, a fusion protein of recombinant NAGLU and a

20 It is essential to understand how impediments alter ecological dynamics via their influenc

21 y enter severe hypothermia could remove this impediment and enable the wide adoption of hypothermia a

22 ith HF, details risk factors and health care impediments, and presents an agenda for future investiga

23 d on carbon-free energy sources, but a major impediment are the costs.

24 Replication forks encounter impediments as they move through the genome, including n

25 ucing end of the substrate imposed by steric impediments at the aglycone-binding site.

26 as at primary clinics or the bedside, faces impediments because they may require highly trained pers

27 ys, we found that CD47(-/-) PMN exhibited no impediment, but slightly enhanced response to and transm

28 Nevertheless, this impediment can be overcome through an E-->K adaptive mut

29 Thus, a replication impediment constitutes a formidable challenge to these o

30 extension step that presents a considerable impediment due to displacement of the 5' template base,

31 The emissions reduction impediment due to infrastructural inertia is significant

32 taking a few steps backward, can bypass the impediments encountered along the translocation path.

33 Multiple impediments exist to achieving value, including misalign

34 rpentinite ores represent the most important impediment for a large scale implementation of sequester

35 d, asymptomatic carrier state is a political impediment for control and potential eradication of foot

36 give rise to resistive switching is a major impediment for engineering reliable and reproducible dev

37 consequence of an ASYNAPTIC1 (Hop1)-mediated impediment for intersister repair.

38 generated by hot spot turnover may create an impediment for recombination in hybrids, potentially lea

39 A major impediment for regeneration of axons within the CNS is t

40 and shape of molecular orbitals presents no impediment for retrieving molecular structure with adequ

41 d computational skill to analyze the data-an impediment for the general public.

42 tified as the most significant thermodynamic impediment for the reduction of CO.

43 nd evolution is by far the single unresolved impediment for their practical applications.

44 They therefore represent major impediments for anticancer therapies, particularly for i

45 verlapping in microscopic digital images are impediments for developing fully automated identificatio

46 of most CPPs, has emerged as one of the main impediments for efficient intercellular transport.

47 of beta3 subunits are some of the molecular impediments for functional expression of malpha6mbeta2be

48 her surveillance radar data, we examined two impediments for nocturnally migrating songbirds in easte

49 One of the main impediments for obtaining DNA sequences from ancient hum

50 le highlighting important knowledge gaps and impediments for randomized controlled trials.

51 Major impediments for structural and biophysical studies of pe

52 lecular elements in alpha6 could be specific impediments for the expression of functional alpha6beta4

53 A central impediment has been the challenge of visualizing invasiv

54 These impediments have greatly hampered the genetic manipulati

55 r species of Drosophila in the face of these impediments, I initiated experimental populations of the

56 s necessary alternative solutions to a major impediment imposed by substitution of the conserved P-lo

57 engue virus infection has been a significant impediment in advancing our understanding of the early e

58 This delta2 "activated" state overcomes its impediment in ATP hydrolysis, with the subsequent releas

59 ss of neuropathic pain mechanisms is a major impediment in developing effective clinical treatments.

60 Drug resistance is a major impediment in medical oncology.

61 However, the main impediment in moving from elegant models with few free p

62 The impediment in OC differentiation culminated in a high tr

63 Fib(AEK) mice exhibited a profound impediment in Staphylococcus aureus clearance following

64 ex-forming sequences has been a considerable impediment in the elucidation of quadruplex folds.

65 lanted cells in host tissue is a substantial impediment in the progress of cellular therapy.

66 It also poses the greatest impediment in the treatment of many CNS diseases because

67 ted mutagenesis in obligates remains a major impediment in understanding microbial pathogenesis.

68 n vitro model of metastasis has been a major impediment in understanding the molecular regulation of

69 onverging target of most, if not all, growth impediments in the CNS.

70 One of the largest impediments in the development of microfluidic-based sma

71 The results highlight important impediments in the development of these formulations and

72 actions from neighboring plants and physical impediments in the rhizosphere.

73 nts when replication is disrupted by certain impediments in vivo.

74 reased activities resulted in serious growth impediments in yeast and bacterial cells instead of impr

75 The taxonomic impediment is characterized by dwindling classical taxon

76 However, the fundamental impediment is that the previously explored materials and

77 An approach to overcoming this impediment is to reduce the space of possible models to

78 lack of animal models capable of identifying impediments limiting bnAb induction and ranking vaccine

79 by payment systems and policies that create impediments, misunderstanding, and sometimes misinformat

80 To overcome this impediment, NMR spin relaxation dispersion experiments a

81 nce and which (2) can explain the associated impediment of conscious perception for additional stimul

82 Impediment of DNA replication can lead to DNA damage and

83 nitors changes of cellular NS levels via the impediment of MDM2 function.

84 and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induc

85 Not only does it remove impediments of secondary structure in the DNA, it also m

86 ibility of a MOF may constitute an intrinsic impediment on its experimental realization.

87 l inspection of images will impose a serious impediment on the pace of biological discovery.

88 ogical models for this purpose faces several impediments, particularly the existence of strong, non-a

89 at DRIM represents a response to replication impediment per se rather than to specific defects in the

90 g immunotherapy has been hampered by various impediments related to the stability and isolation proce

91 transgenesis in parasitic nematodes, several impediments remain before this methodology can become a

92 This variation can either be an impediment, slowing the process of replication, or an op

93 The replicative machinery encounters many impediments, some of which can be overcome by lesion byp

94 circumvent significant inherent quantitative impediments, such as of computational complexity.

95 Instead of antagonizing the growing list of impediments, tackling a common target that mediates axon

96 These studies also highlight the impediments, technical and otherwise, that will have to

97 ters and presents technological advances and impediments that determine the application of these meth

98 Due to technical impediments that have made it difficult to focus on sing

99 I propose that one impediment to a better understanding of the brain is tha

100 ome segregation represent the most important impediment to a successful pregnancy.

101 of HNSCC cells is sufficient to remove this impediment to ABT-737.

102 chain facilities appears to be a significant impediment to access to renal transplants.

103 has been increasingly recognized as a major impediment to achieving effective immunosuppression.

104 Significant liver fibrosis remains an impediment to achieving SVR with short-duration DAA ther

105 An impediment to achieving this is that the current researc

106 he dorsal root ganglion (DRG) is a potential impediment to action potential (AP) propagation towards

107 compared with that of the anode have been an impediment to advance the lithium-ion battery technology

108 A major impediment to advances in understanding, preventing, and

109 utilizes HIV-1 as the challenge virus is an impediment to AIDS research; existing models generally e

110 s-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transpl

111 ct DNA from degradation may pose a potential impediment to application of DNA barcoding and metagenom

112 m presents a combined physical and molecular impediment to axon regeneration.

113 ar matrix in a spinal lesion site is a major impediment to axonal regeneration in mammals.

114 which is unique to MACV GP1, is an important impediment to binding of neutralizing antibodies and con

115 purification and reconstitution is a primary impediment to biophysical studies and to obtaining high-

116 epatitis C virus (HCV) infection has been an impediment to both furthering understanding of virus bio

117 One impediment to broad adoption of ecosystem service inform

118 lack of solid clinical evidence is the main impediment to broader use.

119 Poor access to surgical care is a major impediment to cancer care in sub-Saharan Africa.

120 f tumor immunity and therefore a significant impediment to cancer immunotherapy.

121 ning antitumor immunity remains a persistent impediment to cancer immunotherapy.

122 Tumor hypoxia is an inherent impediment to cancer treatment that is both clinically s

123 Multidrug resistance (MDR) is a major impediment to cancer treatment.

124 ent amounts of high-quality cells remains an impediment to cell-based therapies.

125 thogens using WGS and is therefore a serious impediment to clinical and epidemiological sequencing fo

126 r on tumor metastasis, which is the greatest impediment to clinical management of cancers today.

127 of cellulase enzymes remains a key economic impediment to commercialization of biofuels.

128 A major impediment to comparing the loss of EH during past and c

129 is world heritage ecosystem has been a major impediment to conservation efforts.

130 T or remain untreated due to an inability or impediment to coronary sinus (CS) lead implantation.

131 f finding the native topology can be a major impediment to correct folding to the biologically active

132 of the intra-domain disulfide bond is not an impediment to correction of antibody folding or to inter

133 on, which is identified as another potential impediment to CPP-mediated intercellular transport.

134 ble structural heterogeneity and are a major impediment to crystallization studies.

135 ity for polymerization and aggregation is an impediment to crystallization.

136 of vaginal dysbiosis has been a significant impediment to developing optimal treatment and preventio

137 the setting of advanced disease, remains an impediment to durable clinical responses.

138 Inadequate funding levels are a major impediment to effective global biodiversity conservation

139 -based chemotherapy remains a major clinical impediment to effective management of epithelial ovarian

140 med and can take 48 h or longer, which is an impediment to effective therapy.

141 Drug resistance is a major impediment to effective treatment of breast cancer.

142 A major impediment to effectively utilizing untargeted metabolom

143 A major impediment to expanding PET applications to study the br

144 The degree and nature of the impediment to flux, as well as the potential approaches

145 is after spinal cord injury (SCI) is a major impediment to functional recovery.

146 uantify receptor protein isoforms is a major impediment to functional studies.

147 lethality of Myb-null mutations has been an impediment to identifying roles for c-Myb during lymphoc

148 Significant impediment to improvement has been the requisite use of

149 A major impediment to improving the treatment of concussion is o

150 Furthermore, tsetse's PM is not a physical impediment to infection establishment, but instead serve

151 A major impediment to investigating such processes at the subcel

152 d microstructure of AM parts remains a major impediment to its widespread adoption.

153 inhibition of Tat-transactivation as a major impediment to latency reactivation.

154 The results suggest that one main impediment to learning the optimal strategy in the Monty

155 Chronic allograft rejection is a major impediment to long-term transplant success.

156 asmodium falciparum malaria has been a major impediment to malaria control and threatens prospects fo

157 A major impediment to novel drug development has been the paucit

158 Here we show that the critical impediment to observations of such phase transformations

159 hotomies as scientifically inadequate and an impediment to our ability to integrate the diverse infor

160 that the trabecular meshwork is the primary impediment to outflow and its ablation benefits those ey

161 t the duplicated ACCase in Arabidopsis is an impediment to plastid transformation provides a rational

162 An impediment to potential treatment identification has bee

163 ization of ischemic neural tissue is a major impediment to preservation of function in central nervou

164 tential treatments is often cited as a major impediment to progress and discourages researchers and p

165 A substantial impediment to progress in trials of new therapies in neu

166 aria, need for intravenous treatment, and an impediment to quinidine.

167 Failure of remyelination is a critical impediment to recovery in multiple sclerosis (MS).

168 ilure to undergo remyelination is a critical impediment to recovery in multiple sclerosis.

169 PCs and oligodendrocytes, and as a prominent impediment to remyelination.

170 nt threat to public health and a significant impediment to socio-economic development worldwide.

171 Their extreme reactivity presents an impediment to structural characterization, but their bio

172 ng persistence in most humans and is a major impediment to success of kidney grafts.

173 ardiotoxicity, the most significant clinical impediment to successful anthracycline treatment.

174 A key impediment to successful cancer therapy with adenoviral

175 -glycoprotein (Pgp) represents a significant impediment to successful cancer treatment.

176 Multidrug resistance continues to be a major impediment to successful chemotherapy in cancer patients

177 Toxicity is another major impediment to successful chemotherapy, leading to an imp

178 Resistance to endocrine therapy is a major impediment to successful treatment of breast cancer.

179 to chemotherapeutic drugs, which is a severe impediment to successful treatment.

180 isorders require special care but are not an impediment to successful treatment.

181 A major impediment to synthesizing compounds from CO2 is the dif

182 es, brain pathology and imaging, but a major impediment to testing ASD hypotheses is the lack of huma

183 r genome sequencing projects remains a major impediment to the accessibility of high-throughput seque

184 A major impediment to the broad adoption of MPL in research labo

185 mutagenesis by retroviral vectors is a major impediment to the clinical application of hematopoietic

186 patient morbidity and cost; and has been an impediment to the completion of randomized controlled tr

187 of the sub-Arctic represents a considerable impediment to the construction of roads, thereby greatly

188 undergoing antiretroviral therapy is a major impediment to the cure of HIV/AIDS.

189 Viral diversity is considered a major impediment to the development of an effective HIV-1 vacc

190 complexity of this disease has been a major impediment to the development of appropriate metrics of

191 fic biology of these pathways is an enduring impediment to the development of clinical NR small-molec

192 A major impediment to the development of novel treatment strateg

193 vices and circuits, and can be a significant impediment to the development of practical applications

194 enovirus myocarditis, which is a significant impediment to the development of treatment or prevention

195 We show that unless there is some physical impediment to the diversity of signals possible, then po

196 herapeutic is currently the most significant impediment to the effective management of hemophilia A.

197 A major impediment to the effective treatment of patients with p

198 a represents a substantial knowledge gap and impediment to the eventual licensing of new antiviral dr

199 rial by the growth front, posing a potential impediment to the growth of complex structures.

200 enerational genetic changes is a fundamental impediment to the identifiability of mathematical models

201 ma and Ehrlichia, removing a major technical impediment to the identification of new targets for vacc

202 A major impediment to the implementation of insecticide resistan

203 An impediment to the investigation of mechanisms that drive

204 ght-sensitive proteins remains a significant impediment to the optical control of most cell-biologica

205 nt-3-en-2-one removes a significant previous impediment to the overall route.

206 The lack of authentic standards has been an impediment to the rapid identification of such metabolit

207 y in this rearrangement relies on the steric impediment to the rotation around the C-N bond in the ch

208 memory B cell markers has been a significant impediment to the study of memory.

209 ediated by preexisting antibodies is a major impediment to the success of transplants across allogene

210 to currently available therapies is a major impediment to the successful treatment of hematological

211 pothesize that the proline codons present an impediment to the translation of mgtL, which can be alle

212 A major impediment to the use of adeno-associated virus (AAV)-me

213 obust technology in mouse and human, a major impediment to the use of iPS cells for therapeutic purpo

214 One impediment to the use of tumor necrosis factor-related a

215 The most serious impediment to the worldwide spread of heavy ion therapy

216 ity of their chemical structures is a severe impediment to their further development.

217 ver and above actual math ability--can be an impediment to their math achievement.

218 One impediment to these applications is fluctuations of sing

219 tinum(IV) complexes in vivo is a significant impediment to these complexes being successfully employe

220 A key impediment to this downscaling is that we lack a fully d

221 strongly agreed that fellow turnover was an impediment to training.

222 arse, and this gap in knowledge is a serious impediment to translational research aimed at understand

223 rrying 2 APOL1 risk alleles should not be an impediment to transplantation.

224 stretches, where harsh terrain is seen as an impediment to travel.

225 A major impediment to tuberculosis control in Africa is the diff

226 One impediment to understanding how HSV gE/gI and US9 functi

227 A fundamental impediment to understanding the brain is the availabilit

228 in the hantavirus community is a significant impediment to understanding the ecology and evolutionary

229 ductivity and the pseudogap state remains an impediment to understanding the high transition temperat

230 A major impediment to understanding the impact of environmental

231 ose) (PAR) in a homogeneous form has been an impediment to understanding the interactions of PAR with

232 Perhaps the biggest impediment to understanding these networks is that we ha

233 e interphalangeal joints) presented a slight impediment to visualization.

234 and show that background photons are a chief impediment to voltage sensing.

235 , livestock, and fisheries sectors act as an impediment to, or an opportunity for, enhanced resilienc

236 There are many impediments to acceptable and accurate administration of

237 d hyperalgesia and tolerance are significant impediments to achieving adequate pain relief with opioi

238 Finally, we focus on the current impediments to adopting such an approach in a wider cont

239 Impediments to animal movement are ubiquitous and vary w

240 In this article, we review the historical impediments to automation in the microbiology laboratory

241 he host spinal cord, which contains numerous impediments to axon growth.

242 ssue at the injury site are considered major impediments to axon regeneration.

243 To test for the role of intrinsic impediments to axon regrowth, we analyzed cell growth co

244 or nSNPs show opposite patterns, forecasting impediments to building diagnostic tools aiming to simul

245 cy and holds great promise for resolving the impediments to developing practical direct ethanol fuel

246 pical older patient with MDS have been major impediments to development of effective novel therapies.

247 Major impediments to development of vaccines and drugs for Pla

248 Impediments to DNA replication are known to induce gross

249 howed that the cross-link constituted strong impediments to DNA replication in HEK293T cells, with th

250 hat imposes cell cycle delays in response to impediments to DNA replication.

251 ninstructional premutagenic lesions that are impediments to DNA synthesis.

252 es is needed to successfully negotiate these impediments to drug delivery.

253 One of the several impediments to effective oncolytic virus therapy of canc

254 Impediments to enzyme replacement therapy are the absenc

255 There are major impediments to finding improved DEET alternatives becaus

256 The impediments to integration were many, but they are gradu

257 However, the parasite faces no apparent impediments to invading the entire archipelago, with unk

258 ity in those disorders, as well as potential impediments to its application.

259 As practice reduces the impediments to more complex computation, the chunking st

260 Rather than simply acting as impediments to movement, interactions of trafficking car

261 e barriers and 10% cited a single barrier as impediments to optimal adherence.

262 owding, environmental degradation, and other impediments to productivity.

263 Major impediments to progress in understanding, early diagnosi

264 in alterations in the disorder, highlighting impediments to progress, recent developments, and promis

265 Although we identify multiple impediments to progress, we conclude that the current st

266 t often cited the following factors as major impediments to pursuing basic investigation: pressure to

267 axon regrowth and extrinsic, scar-associated impediments to regeneration results in significant regen

268 ing intrinsic and scar-associated, extrinsic impediments to regeneration results in significant regro

269 Thus, as in the CNS, impediments to reinnervation in the PNS arise after init

270 The precise impediments to replication fork progression at telomeric

271 ural alterations in DNA can serve as natural impediments to replication fork stability and progressio

272 ensure that this process is not disrupted by impediments to replication.

273 natural responses scientists use to surmount impediments to research.

274 ed an RNA-Seq simulator that models the main impediments to RNA alignment, including alternative spli

275 records represent one of the most insidious impediments to seafood traceability, and suggest that wi

276 rctic Peninsula for environmental or trophic impediments to shoreward expansion.

277 While these factors form impediments to statistical rigor, they can to a large ex

278 Among impediments to successful gout management are diagnostic

279 , this work largely removes any instrumental impediments to the adoption of QDs as routine tools for

280 PRn-mediated toxicity may result from broad impediments to the dynamics of cell structure and inform

281 into functional groups that help explain the impediments to the emergence of maraviroc-associated R5

282 s that escape the primary tumor mass are key impediments to the eradication of tumors in glioma patie

283 One of the major impediments to the implementation of displacement chroma

284 phorylation by ZAP70, appear to be the major impediments to the phosphorylation of SLP76 (SRC homolog

285 The lack of impediments to the replication of the VSV core in eukary

286 HD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT.

287 esistance and long term toxicity are serious impediments to their use, thus requiring the development

288 n a potential outbreak scenario and identify impediments to these efforts, we studied 84 invasive ser

289 are unable to unwind quadruplexes, which are impediments to transcription, translation, or replicatio

290 Major impediments to understand the transport mechanism are th

291 One of the major impediments to using electroorganic synthesis is the nee

292 We suggest that such impediments to variation in signal form will be uncommon

293 y (ART) is important, but there are multiple impediments to VL testing in resource-constrained settin

294 This self-pairing presents an impediment toward binding of the RNA by nucleic acid-bas

295 A major impediment toward understanding its nontemplating roles

296 with schizophrenia and represent significant impediments toward successful psychosocial functioning w

297 To overcome this impediment, we have developed a robust NMR restraint gui

298 We overcome these impediments with high-resolution measurements on the str

299 replisome to continue DNA synthesis without impediment, with leading strand re-priming by DnaG.

300 In asthma, focal airflow impediment within the lungs can be markedly persistent o