ライフサイエンスコーパス: imperfect

1 ality to detected variants is imperative but imperfect.

2 omography and computed tomography scans, are imperfect.

3 vior, but knowledge of their interactions is imperfect.

4 , and PTLD tumor light chain restriction was imperfect.

5 ting and cardiac magnetic resonance, remains imperfect.

6 s (MS), and existing diagnostic criteria are imperfect.

7 kelihood identified, so Bayesian learning is imperfect.

8 Diagnostic consistency in plus disease is imperfect.

9 Human behavior is imperfect.

10 SF was good but agreement between titres was imperfect.

11 CIS who were treated with local excision are imperfect.

12 iated diagnostic and treatment paradigms are imperfect.

13 monitoring strategy, even when compliance is imperfect.

14 nitive identification remain both scarce and imperfect.

15 alic acid production and disease severity is imperfect.

16 ssessment of individual risks remains highly imperfect.

17 nd models for predicting target activity are imperfect.

18 e-directed mutagenesis method is popular but imperfect.

19 xpression of the PrD of Gts1p, containing an imperfect 28 residue glutamine-alanine repeat, was suffi

20 n a family with hypomineralized amelogenesis imperfect a (AI), a condition in which tooth enamel form

21 Our imperfect ability to detect and report disease hinders a

22 ppa = 0.55-0.62, P < 0.01) and had a strong, imperfect ability to discriminate between persons retain

23 o be causal are not always so, mainly due to imperfect ability to predict the pathogenicity of varian

24 hysical activity estimates corrected with an imperfect accelerometer measurement might over- or under

25 tion versus kinetic limitations arising from imperfect accommodation of organic species into the part

26 Because of imperfect accuracy assessment, the best assessment curre

27 on of ribonucleotides in the nucleus and the imperfect accuracy of replicative DNA polymerases in cho

28 Our model estimates that the impact of imperfect adherence was worst in children, highlighting

29 7.7 to 20.9 lifetime cases per 1000 persons [imperfect adherence] vs. 31.3 lifetime cases per 1000 pe

30 0 865 to 30 869 life-years per 1000 persons [imperfect adherence]).

31 ain optimal control policies in the event of imperfect, aggregated data.

32 Although at least one imperfect amphipathic repeat sequence (KAKEGV) is requir

33 Because of its imperfect amphipathicity, protegrin binds weakly, at mos

34 tion in DSA- recipients and (d) alone, is an imperfect AMR marker needing correlation with routine hi

35 their transient (time-dependent) response is imperfect and a small amount of heat is scattered.

36 However, this modularity is imperfect and also restricted to short peptide stretches

37 e same time, cluster analysis is known to be imperfect and depends on the choice of algorithms, param

38 Second, surveillance methods are imperfect and fail to detect some individuals.

39 Acknowledging the imperfect and incomplete relationship between Ag-stimula

40 Management strategies are imperfect and involve burdensome long-term dietary exclu

41 ies are long lasting and full of detail, yet imperfect and malleable.

42 Although our therapies are imperfect and many patients remain symptomatic, appropri

43 or identifying in vivo targets of an RBP are imperfect and not amenable to examining small numbers of

44 Results reveal imperfect and obligatory within- and across-modality int

45 gesting that the discrimination mechanism is imperfect and occasionally leads to autoimmunity due to

46 induced by oral poliovirus vaccine (OPV) is imperfect and potentially allows immunized individuals t

47 These models are imperfect and refinement would allow more accurate progn

48 rget duplex structures that include perfect, imperfect and seedless duplexes.

49 They are thus imperfect and should be interpreted as the best availabl

50 type or fitness from nucleotide sequence are imperfect and that predicting the timing and course of e

51 y, yet diagnostic agreement among experts is imperfect and the precise factors involved in clinical d

52 Current control strategies are imperfect and there is an unmet need for new antiviral t

53 maller have a longer G1, the compensation is imperfect and they still bud at smaller cell sizes.

54 eripheral clinical specimens, which may have imperfect and uncertain sensitivity and specificity, so

55 hypothesized that our reference standard was imperfect and used statistical modeling to investigate t

56 induced by oral poliovirus vaccine (OPV) is imperfect and wanes with time, permitting transmission o

57 can be challenging when diagnostic tests are imperfect and when some individuals go for long periods

58 However, negative selection is imperfect, and autoreactive T cells exist in healthy ind

59 itial assembly reaction can be predominently imperfect, and completion involves the slow correction o

60 Current renal function measures are imperfect, and cystatin C (CysC) is promoted as a better

61 Current diagnostic tests are imperfect, and modern therapy is nonspecific.

62 the steady-state assumption is biologically imperfect, and several key stoichiometric coefficients a

63 However, imaging modalities are imperfect, and some will ultimately have no HCC on expla

64 ssay sensitivity and specificity were indeed imperfect, and we were able to draw several conclusions

65 Although imperfect AREs make up 99.9% of the motifs, the degree o

66 redictions of climate change in the suite of imperfect Atmosphere Ocean Science (AOS) computer models

67 new environment in order to strike an often imperfect balance between the host and the infectious pa

68 es in two dimensions can be stopped, even by imperfect barriers perforated by a series of gaps.

69 Targets are determined by imperfect base pairing of the microRNA to the 3'-UTR of

70 gonaute protein complexes, mature miRNAs use imperfect base pairing to recognize sequences in messeng

71 ssed and functional miRNAs, i.e. that due to imperfect base pairing, two distinct microRNAs (miRNAs)

72 changes in stability induced by mutations of imperfect base pairs, as in naturally occurring polymorp

73 ow that STAU1-binding sites can be formed by imperfect base-pairing between an Alu element in the 3'

74 PF1088 is dependent upon the presence of an imperfect BRE and is abolished when the pf1089 BRE is re

75 and 10-year IBTR probabilities demonstrated imperfect calibration and discrimination, with a concord

76 However, predictive germination was imperfect, calling for some degree of bet hedging.

77 . cristinae metapopulation show that locally imperfect camouflage reduces population size and that th

78 even when detection of symptomatic plants is imperfect, can lead to very effective control.

79 Imperfect capture success, diagnostic sensitivity, and v

80 lenticulo-sutural dysplasia and osteogenesis imperfect, caused by mutations in the COPII coatomer com

81 from the convolution effects associated with imperfect cell synchronization.

82 This is necessary to accommodate for imperfect centering during endoscopy and the nonuniform

83 e found that Bmp9 knockout in mice led to an imperfect closure of the DA.

84 The ectodomain itself forms an imperfect coil that may undergo conformational shifts to

85 metallic electrode, allowed by the intrinsic imperfect compactness of the functionalization layers, w

86 While this is an imperfect comparison, the data suggest that the separati

87 perativity and low miRNA cooperativity, (ii) imperfect complementarity between miRNA and mRNA was pre

88 tic gene expression by binding to regions of imperfect complementarity in mRNAs, typically in the 3'

89 s) often possess multiple binding sites with imperfect complementarity to a given sRNA.

90 lian miRNAs tend to bind to target mRNAs via imperfect complementarity, understanding exactly which t

91 rently repress multiple mRNA targets through imperfect complementarity.

92 CACE estimates in stepped wedge trials with imperfect compliance could enhance reporting and interpr

93 ma and how any benefits might be affected by imperfect compliance or increased variability in the hom

94 olved rDNA sequence variation resulting from imperfect concerted evolution of the ribosomal DNA regio

95 he computational gene model predictions were imperfect, containing errors such as missing exons, pred

96 between the system and the environment, and imperfect control of the system parameters.

97 adening in ensemble measurements, as well as imperfect control over size, shape, faceting, surface re

98 nding to cognate oriP DNA, which comprise 20 imperfect copies of a 30-bp dyad symmetry enhancer and a

99 Imperfect copies of these U1 snRNA genes, also located o

100 xtraordinary variety of phenotypes that show imperfect correlation with mutations in the GBA gene.

101 btained by both methods (n = 38 samples) was imperfect; correlation between log-transformed titres (r

102 or DNA one nucleotide at a time, and due to imperfect coupling, not every ATP hydrolysis event produ

103 ctures within starch granules, suggestive of imperfect crystallite development.

104 a method that exploits commonly encountered imperfect crystals and enables model-free phasing.

105 Here we show that fragmentation of large, imperfect crystals into microcrystals or nanocrystals ca

106 ions, limitations of diagnostic testing, and imperfect data capture remain major limitations to accur

107 ng because of the massive volume of data and imperfect data quality.

108 However, trees can be imperfect datatypes when summarizing multiple trees.

109 We account for Kepler's imperfect detectability of such planets by injecting syn

110 time point, failure to account properly for imperfect detection and treating the environment as a st

111 The imperfect detection in both, DNA and RNA, was identified

112 be metacommunity structure that accounts for imperfect detection in survey data-detection error-corre

113 Occurrence models that account for imperfect detection of species are increasingly used for

114 streets while controlling for cofactors and imperfect detection of vectors.

115 BS surveys were low, and models that ignored imperfect detection severely underestimated the proporti

116 After correcting for imperfect detection, we found that local land-use determ

117 s applicable to other diagnostic assays with imperfect detection.

118 d we compute data analytics that correct for imperfect detection.

119 c testing based on influenza vaccine status, imperfect diagnostic test characteristics, and confoundi

120 Imperfect diagnostic testing reduces the power to detect

121 Challenges in standardized surveillance and imperfect diagnostic tools have resulted in patchy local

122 dies demonstrated that COUP-TFII binds to an imperfect direct repeat COUP-TFII recognition sequence (

123 we demonstrated that FsrA also binds to two imperfect direct repeats separated by 13 bp, based on th

124 erizes these proteins generally binds to two imperfect direct repeats separated by a number of bases

125 dence that Zta binds to a sequence-specific, imperfect DNA hairpin formed by an inverted repeat withi

126 ight from the RNA world to the contemporary 'imperfect' DNA world.

127 It contains one long, imperfect double helix (domain I), one branched domain (

128 appear to depend on long and stable, albeit imperfect, duplexes between distant mtDNA segments.

129 racers in the atmosphere, with corresponding imperfect eddy-diffusivity parameterization models are u

130 d the one licensed vaccine has a complex and imperfect efficacy profile.

131 ed to balance the limitations of dwelling in imperfect environmental conditions and the risks associa

132 This suggests imperfect epigenetic maintenance of viral transcription

133 ferropnictide thin films seem compromised by imperfect epitaxial growth and poor connectivity of the

134 iscovered that the EGFR promoter contains an imperfect estrogen response element and that ERbeta repr

135 actin was in the form of small oligomers and imperfect filaments.

136 The first generation analogue is an imperfect fit to the catalytic site with a long ion pair

137 However, "imperfect" floral iridescence does not lead to mistaken

138 After processing from imperfect fold-back structures, miRNAs are incorporated

139 he inclusion and exclusion errors related to imperfect food targeting.

140 years ago) is real and not an artefact of an imperfect fossil record: rapid diversification of animal

141 tion, however, can be jeopardized because of imperfect functional annotation of genes, and ambiguity

142 Even with imperfect funding and resource-need data, the proposed c

143 intrinsic to exome sequencing is inherently imperfect, generating large amounts of unintended off-ta

144 ver, presymptomatic diagnosis is hampered by imperfect genotype-GALC activity-phenotype correlations.

145 t uncovered a compensation mechanism, albeit imperfect, given the phenotype of affected individuals,

146 ycosyltransferases may in vitro complete the imperfect glycosylation pattern of proteins, recombinant

147 ur findings show that culture plus MAT is an imperfect gold standard against which to compare alterat

148 omarker may be a reflection of errors in the imperfect gold standard itself, rather than poor perform

149 of overweight or obese children by using the imperfect gold standard methodology.

150 steatosis index (HSI) was analyzed using the imperfect gold standard methodology.

151 e and the sensitivity and specificity of the imperfect gold standard.

152 Many phenotypes have imperfect heritability, so that a measurement of the phe

153 t association between the numbers of perfect/imperfect hexamers and repeat coding for single amino ac

154 ification, and they revealed significant but imperfect homology to segments of commensal Acinetobacte

155 an recover from infection, (ii) vaccines are imperfect, (iii) individuals are ex ante heterogeneous,

156 a (HCC) is a devastating malignancy in which imperfect imaging plays a primary role in diagnosis.

157 ity and sensitivity of detection methods are imperfect in complex samples, including in excreta.

158 wever, the predicted body weight approach is imperfect in patients with ARDS because the amount of ae

159 However, imperfect in silico models--even at the secondary struct

160 ty, and we observed that the correlation was imperfect, indicating that the fitness effects of mutati

161 al organisms frequently benefit from pooling imperfect individual estimates.

162 the profits under two scenarios (perfect and imperfect information about future electricity prices),

163 To overcome the limits of incomplete and imperfect information linking genes to disease, we pool

164 y cannot be easily found, reflecting current imperfect information of the target organism.

165 alytical inaccuracies or the implications of imperfect information, structuring and communicating cau

166 hmark and long-standing challenge problem in imperfect-information game solving.

167 explain how humans understand language given imperfect input.

168 icacy in delivery of human Abs might reflect imperfect interaction between the human membrane IgH cha

169 e substrate and thus presents an elastically imperfect interface.

170 was there evidence for a significant role of imperfect intestinal immunity in the transmission of pol

171 ical cruciform extrusion at both perfect and imperfect inverted repeat (IR) sequences.

172 ted sequence or by template switching within imperfect inverted repeat (quasipalindrome, QP) sequence

173 is called BirA has been reported to bind an imperfect inverted repeat located upstream of the biotin

174 ate-switch" class of mutations that arise in imperfect inverted repeat sequences by DNA-strand misali

175 ysis of human miR-29a promoter identified an imperfect inverted repeat spaced by one nucleotide DNA m

176 e-offs might be found in the many naturally "imperfect" iridescence-producing structures found in ani

177 nd that the loss in detection ability due to imperfect knowledge of the leakage probability can be qu

178 Imperfect knowledge of the times at which 'snapshots' of

179 In practice, imperfect labeling biases the distribution of oligomeric

180 idated using computer-simulated data and the imperfect labeling was quantified in cells with ion chan

181 ytic exchange current density-to account for imperfect light absorption, charge transport and catalys

182 processes, including monument building, with imperfect, limited, presence-only data.

183 Calcineurin inhibitors are imperfect long-term maintenance immunosuppressive agents

184 or decreases at specific loci) that reflects imperfect maintenance of epigenetic marks.

185 ering that is present in most samples due to imperfect manufacturing procedures.

186 icrobiome composition in several animals and imperfect marker specificity and sensitivity.

187 ive GATA and ETS (FGF) binding sites contain imperfect matches to consensus motifs.

188 ew adaptation hypothesis, using a cascade of imperfect mathematical integrators, that reproduces the

189 However, distance is an imperfect measure of exposure because it does not quanti

190 Body mass index is an imperfect measure of surgical risk in this population, p

191 vitamin B-12 concentration is known to be an imperfect measure of vitamin B-12 status.

192 e-dimensional (3D) reconstruction due to the imperfect mechanical control capability of the specimen

193 ay not be a major driver of the evolution of imperfect mimicry and that other factors, such as ecolog

194 her provide evidence that this tolerance for imperfect mimicry is attributable to collaboration betwe

195 earning in mimicry evolution, and shows that imperfect mimicry is expected to be the norm.

196 Although the forces behind the evolution of imperfect mimicry remain poorly studied, recent hypothes

197 story undoubtedly affects the development of imperfect mimicry, ecological community context has larg

198 especially those regarding the evolution of imperfect mimicry.

199 be considered when studying the evolution of imperfect mimicry.

200 lection on small-bodied individuals leads to imperfect mimicry.

201 en ignored and may be an important driver of imperfect mimicry.

202 sms by which animals learn might explain how imperfect mimics survive.

203 stinct target sites that generate distorted, imperfect miRNA-target duplexes.

204 raphic pump, with the worst of these mixers, imperfect mixing accounted for 99.6% of the observed noi

205 However, imperfect modal matching and finite photon absorption ra

206 dictive skill for the forced response of the imperfect model by combining appropriate concepts from i

207 Equilibrium statistical fidelity of the imperfect model on suitable coarse-grained variables is

208 are intrinsic natural barriers to improving imperfect model sensitivity.

209 molecular investigation, in part because of imperfect model systems.

210 with equilibrium statistical fidelity of the imperfect model, a direct link is developed between the

211 anding and improving the predictive skill of imperfect models for complex systems in their response t

212 ant role of additional stochastic forcing of imperfect models in order to systematically improve the

213 However, since mice are imperfect models of human macrophage biology, for exampl

214 n metric for model error, and the ability of imperfect models to capture the true sensitivity.

215 These results include simple examples of imperfect models with perfect equilibrium statistical fi

216 Even where there are accepted, albeit imperfect models, the leap from promising preclinical dr

217 and show that much can be learned from even imperfect models.

218 However, imperfect modularity with particular domains, lack of hi

219 These reports of imperfect niche tracking imply shifts in species' realiz

220 nkeypox also clarifies the various ways that imperfect observation can impact inference of transmissi

221 . growth, selection, population dynamics) or imperfect observation of biological systems.

222 rica (197 region-years) while accounting for imperfect observations and grounding our findings in spe

223 ti-event capture-recapture approach to model imperfect observations of true epidemiological states.

224 e genetic brittle bone disease, osteogenesis imperfect, oim, is characterized by a replacement of the

225 predictions of "death before discharge" were imperfect-only 104 of 187 of patients with a prediction

226 ingly reflects an ability not just to detect imperfect or inaccurate claims but also to assess what i

227 ple genes through binding to its target with imperfect or perfect complement.

228 atic cancer patients remains fractured, with imperfect patient selection and ongoing bias in referral

229 ial treatment regimes, individual drugs have imperfect penetration throughout the body, so there may

230 Inadequate knowledge and imperfect phlebotomy procedures were noted.

231 t viewpoint of a fly photoreceptor being an 'imperfect' photon counting machine, we explain how these

232 ally buried into an insulating layer and the imperfect positioning of the tip with respect to the NP

233 sed Streptococcus pyogenes Cas9 (SpCas9) are imperfect, possessing only partial or unproven efficacie

234 f the ACSL3 promoter sequence identified two imperfect PPAR-responsive elements (PPRE) located in the

235 Meaningful but imperfect predication is possible based on underlying ca

236 Aortic diameter is an imperfect predictor of aortic complications in connectiv

237 However, composition was an imperfect predictor of inclusion formation in Drosophila

238 ionally, shared phenotypes in one assay were imperfect predictors for shared phenotypes in other assa

239 However, this data is imperfect, preventing input into computational algorithm

240 ovel protein docking algorithm that utilizes imperfect protein-protein binding interface prediction f

241 rD, a pairwise docking algorithm, which uses imperfect protein-protein binding interface prediction t

242 tcomes, but their studies measure impacts on imperfect proxies for ecosystem services (e.g., avoidanc

243 iagnosed cases are available and serve as an imperfect proxy of incidence.

244 unt for inter-assay variability arising from imperfect QMMs and generates estimates of pathogen densi

245 sions, these approaches have been limited by imperfect quantum state selectivity.

246 late, yet these correlations are often quite imperfect, raising questions as the origins of such mism

247 opic models are considered as a result of an imperfect recapitulation of the specific tumor microenvi

248 One reason for this imperfect record is that organisms without hard parts, s

249 ally depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines.

250 ion, but also ribosomal frameshifting and/or imperfect repeat DNA replication, expansion, and repair,

251 face compared to 4RL isoform (which has four imperfect repeats (R) long (L) isoform).

252 te that, in 3RS tau isoform (which has three imperfect repeats (R) short (S) isoform), amino acids ar

253 Results further show that perfect and imperfect repeats have significant association with the

254 in seven contiguous approximately 12-residue imperfect repeats, which presumably contain kinase recog

255 f nearly perfect tandem repeats and adjacent imperfect repeats.

256 pregnant women have enjoyed better-although imperfect-representation in research; and (4) recommenda

257 A common shortcoming of ICDs is imperfect rhythm discrimination, resulting in the delive

258 In addition, ligand-jump experiments reveal imperfect riboswitching of single mRNA molecules.

259 ition to the local requirement for a central imperfect RNA duplex containing the modified adenosines,

260 cape evolution and network selection through imperfect searches for dynamically accessible states.

261 nstead was correlated with their adoption of imperfect secondary structures.

262 However, non-canonical binding modes from imperfect/seedless duplexes are not well predicted by co

263 In any setting, their power is limited by imperfect selectivity (binding of undesired targets) and

264 challenging to therapeutically target due to imperfect selectivity that leads to either off-target to

265 influence of psychosocial factors, good but imperfect self-care adherence, and health system failure

266 Organisms can be thought of as imperfect self-replicators which produce closely-related

267 acute kidney injury for decades, despite its imperfect sensitivity and specificity.

268 Imperfect sensitivity of diagnostic tests and lack of sp

269 e RT-PCR; however, this benchmark itself had imperfect sensitivity.

270 of tuberculosis (TB) but still suffers from imperfect sensitivity.

271 acid C-terminal domain (AP7C) that exhibits imperfect sequence homology to the C subclass of the int

272 ridylation of RNA can be induced at sites of imperfect sequences, and that Pus7p and snR81 RNP can ca

273 ctors that limited novel gene discovery: (1) imperfect sequencing coverage across the exome hid poten

274 lacing missing protein ion transporters with imperfect small molecule mimics.

275 For the hPhe analog, an imperfect stereochemical complementarity could be overco

276 D and Tax epitopes with HLA-A2 are close but imperfect structural mimics and that in contrast with ot

277 The use of linked infertility genes even if imperfect, substantially reduced transgene flow in a wid

278 pic ones, and demonstrate how facets such as imperfect substitutability can arise in a more straightf

279 for which contrast enhancement serves as an imperfect surrogate for tumor volume and is influenced b

280 and may not fully capture uncertainty due to imperfect surveillance data and uncertainty about the tr

281 This imperfect synchronization, observed in the beta frequenc

282 vil of oxidative metabolism, a product of an imperfect system.

283 Considering the imperfect tagging of imputation and potential overestima

284 ranscription factors containing two or three imperfect tandem repeats of the Myb DNA-binding domain (

285 METHODOLOGY/PRINCIPAL FINDINGS: To deal with imperfect test sensitivity affecting the response variab

286 f this paper is to investigate the impact of imperfect test sensitivity on the determination of predi

287 However, the effects of imperfect tests in longitudinal data analyses are not as

288 have now demonstrated that niche tracking is imperfect, that species' climate niches may vary with po

289 transposases, Mos1 and Mboumar-9, for their imperfect transposon IRs in each step of transposition:

290 MS is a complex and devastating disease with imperfect treatment strategies.

291 ance and low-power electronic circuits using imperfect two-dimensional topological insulators.

292 cal splice signals as pathogenic, but due to imperfect understanding of RNA splice signals other vari

293 However, an imperfect understanding of the precise biologic mechanis

294 iovirus circulation in most of the world and imperfect vaccination coverage are resulting in immunity

295 xes, and structural studies revealed that an imperfect variant of this motif lacking the (D/E) residu

296 Owing to imperfect vertical transmission, many heritable microbes

297 Furthermore, imperfect, waning intestinal immunity among older childr

298 itions of luminal A and B breast cancers are imperfect when compared with multigene expression-based

299 lammatory response, the outcome is generally imperfect, with some degree of fibrosis, which is define

300 he response to the repellent leucine is also imperfect, with the sign of the two phases inverted with

301 ion blocks the degradation of a structurally imperfect yet biochemically competent brassinosteroid (B