ライフサイエンスコーパス: impermeant

1 faster than DTT), whereas the parent TCEP is impermeant.

2 positively charged and is therefore membrane-impermeant.

3 lammonium (TEA+) and choline were relatively impermeant.

4 , which is frequently assumed to be membrane impermeant.

5 cells with drugs that are normally membrane impermeant.

6 rejected as drugs because they are membrane-impermeant.

7 ied by higher capillary blood flow with cell impermeants.

8 apeutic agents are blood-brain barrier (BBB) impermeants.

9 with either SKF96365 (30-100 microM) or cell-impermeant 1,2-bis(o-amino-5-bromophenoxy)ethane-N,N,N',

10 ane-permeant biotin maleimide and a membrane-impermeant 2-((5(6)-tetramethylrhodamine)carboxylamino)

11 tions GAT-1 is almost insensitive toward the impermeant 2-(trimethylammonium)ethyl methanethiosulfona

12 confirmed by blocking cysteine residues with impermeant 2-sulfonatoethyl methanethiosulfonate.

13 embrane permeant (biotin maleimide (BM)) and impermeant (2-((5(6)-tetramethylrhodamine)carboxylamino)

14 Furthermore, membrane-impermeant [2-(trimethylammonium)ethyl]methanethiosulfon

15 Permeant (300 microM nicotine) and impermeant (5 mM carbachol) cholinergic agents were used

16 [gamma-(32)P]ATP dephosphorylation, and the impermeant AK inhibitor, diadenosine pentaphosphate, red

17 ation of ERK was not inhibited by a membrane impermeant alpha1-blocker, suggesting alpha1 signaling i

18 main(s) based on accessibility to a membrane-impermeant amine-reactive reagent.

19 e was measured by covalent labeling with the impermeant amino reagent, trinitrobenzenesulfonic acid.

20 AMPA/KA receptors or to the existence of AGB-impermeant AMPA/KA receptor complexes.

21 d tamoxifen ethyl bromide (QTam), a membrane impermeant analog of Tam, rapidly induced apoptosis in H

22 A membrane-impermeant analog of tamoxifen, ethylbromide tamoxifen,

23 h Oregon Green maleimide carboxylic acid, an impermeant and fluorescent thiol-reactive agent.

24 QAQ is membrane-impermeant and has no effect on most cells, but it infil

25 n external cysteines were protected with the impermeant and nonfluorescent agent, methanethiosulfonat

26 e cytosol; it is effectively plasma membrane-impermeant and subject to rapid degradation within endos

27 However, because annexins are impermeant and unable to bind PS at low calcium concentr

28 otonated molecule is not completely membrane-impermeant and, therefore, overall drug uptake is less p

29 Small cell impermeants and PEG-20k in LVR solutions increased toler

30 In the presence of the impermeant anion gluconate, glutamate pulses activated s

31 but not when external Cl- was replaced by an impermeant anion.

32 Replacement of the external Cl- with an 'impermeant' anion, such as SO42-, CH3SO3-, gluconate or

33 However, substitution of Cl- by the larger (impermeant) anion gluconate had no effect on the reversa

34 hore Clomeleon demonstrated that cytoplasmic impermeant anions ([A](i)) and polyanionic extracellular

35 nsporters, including KCC2, and extracellular impermeant anions ([A]o) of the extracellular matrix are

36 identified a smaller contribution of fixed, impermeant anions ([A]o) to lowering [Cl(-)]i in RT neur

37 s reduced to 0.9 in solutions comprising the impermeant anions aspartate, methanesulfonate, sulfate,

38 follow a titration of intracellular membrane-impermeant anions by the intracellular accumulation of p

39 ant elements of Cl(-) homeostasis, but local impermeant anions determine the homeostatic set point fo

40 e that, rather than ion transporters, "local impermeant anions establish the neuronal chloride concen

41 sisted in the presence of potassium salts of impermeant anions, and could be abolished by barium, a n

42 erminants of neuronal [Cl(-)]i - cytoplasmic impermeant anions, polyanionic extracellular matrix (ECM

43 complete replacement of external Cl(-) with impermeant anions, tau(c) showed little voltage dependen

44 rge valency (z(x)) of intracellular membrane-impermeant anions, X(-)(i).

45 free external solutions containing different impermeant anions.

46 The cell-impermeant barbiturate N-glucoside amobarbital did not i

47 thelial cells is critical for maintaining an impermeant barrier and epithelial cell polarity.

48 eveloped tight junctions (TJ) to maintain an impermeant barrier and segregate plasma membrane functio

49 Cell surface biotinylation using an impermeant biotinylating reagent confirmed the immunocyt

50 Cell-surface biotinylation using an impermeant biotinylating reagent showed that mutations o

51 of hNET-specific antibodies and the membrane-impermeant biotinylating reagent sulfosuccinimidobiotin

52 An impermeant biotinylating reagent, sulfosuccinimidyl 2-(b

53 Access to a membrane-impermeant biotinylation reagent as well as protease sen

54 ssion of EAAC1, as measured using a membrane impermeant biotinylation reagent combined with Western b

55 virions and could be labeled with a membrane-impermeant biotinylation reagent, indicating surface exp

56 ion of EAAC1 as measured by using a membrane-impermeant biotinylation reagent.

57 when pH was similarly lowered using membrane-impermeant biphthalate.

58 reduced by DTT and reoxidized by a membrane-impermeant bis-quaternary ammonium derivative of diamide

59 blockers of Kir3.1/Kir3.4, but as relatively impermeant blockers of Kir2.1.

60 was mimicked by application of the membrane-impermeant BSA-conjugated DEX, and intracellular blockad

61 regulation, and methylcarbamylcholine (i.e., impermeant but with low efficacy) blocked nicotine induc

62 showed that the hydrophilic dye Alexa 488 is impermeant, but lipophilic FM1-43 labels the seal.

63 ase (CA) inhibitor methazolamide, relatively impermeant CA inhibitor benzolamide, vanilloid receptor

64 Impermeant CA inhibitors abolished net perfusate CO2 los

65 permeant CA inhibitor methazolamide (MTZ) or impermeant CA inhibitors.

66 Membrane-impermeant Ca(2+)-sensitive dye was introduced into the

67 nd identified as inwardly rectifying, proton-impermeant, Ca(2+)-permeant cation channels.

68 ify a family of peptides that carry membrane-impermeant cargos across synthetic membranes.

69 ntial determinations and recordings with the impermeant cation N-methyl-glucamine, this current shows

70 )H]ryanodine binding and the actions of this impermeant cation on the interaction of the reversible r

71 altered by replacement of external Na+ by an impermeant cation, but not when external Cl- was replace

72 n the extracellular Na+ was replaced with an impermeant cation, N-methyl-D-glucamine.

73 helator, 2, 2'-bipyridyl, in contrast to the impermeant chelator bathophenanthroline disulfonate, cau

74 ther Na(+) was replaced by permeant Li(+) or impermeant choline.

75 P, 50 nmol (5 mul)-1), a blood-brain barrier-impermeant cholinergic muscarinic receptor antagonist, e

76 a small fluorescent chelator whose membrane-impermeant complex with nontoxic Zn(2+) ions binds tight

77 ibition by bathocuproine disulfonate, a cell-impermeant Cu(I) chelator.

78 was sensitive to inhibition by the membrane-impermeant cysteine reagents, MTSET or MTSES, suggesting

79 were tested for sensitivity to the membrane-impermeant cysteine-specific reagent (2-sulfonatoethyl)

80 hese PCFT mutants, were then labeled with an impermeant, cysteine-specific biotinylation reagent (MTS

81 Here we report cytoprotection by a cell-impermeant derivative of strychnine.

82 externally or internally, whereas a membrane-impermeant derivative TRAM-30 blocked the channel only w

83 ck by externally applied quaternary membrane-impermeant derivatives of lidocaine (QX314 and QX222) an

84 ompatible with the observation that membrane-impermeant derivatives of progesterone can induce matura

85 ffected cells remained resistant to membrane-impermeant DNA stains, suggesting that loss of membrane

86 prevented the passage of blood-brain barrier-impermeant drugs (such as morphine, sucrose and mannitol

87 an opportunity for delivery of otherwise BBB impermeant drugs.

88 as shown by staining cells with the membrane-impermeant dye 7-aminoactinomycin D.

89 also delivered the larger, anionic membrane-impermeant dye Alexa Fluor 546 but did not deliver a qua

90 luorescence nuclear staining with a membrane-impermeant dye and by morphologic criteria.

91 ot affect transmural ion conductance or cell-impermeant dye flux but the baseline ion conductance was

92 cone were investigated by using the membrane-impermeant dye FM1-43.

93 Large(myd) myocytes rapidly take up membrane impermeant dye following cyclical cell stretching.

94 (SMTPs) delivered the zwitterionic, membrane-impermeant dye tetramethylrhodamine (TAMRA) into cells e

95 alpain 4-deficient hearts took up a membrane-impermeant dye, Evans blue, indicating plasma membrane d

96 nti-DNA antibodies or an ultrasensitive cell-impermeant dye, YOYO-1, were first developed using Enter

97 These cell-impermeant dyedrons exploit efficient intramolecular ene

98 ge in patches of cells positive for membrane impermeant dyes.

99 f islet survival is reproduced by a membrane-impermeant E(2) formulation and a selective GPER agonist

100 The membrane-impermeant E(2)BSA conjugate, shown to bind endothelial

101 These effects were mimicked by the membrane impermeant E2-BSA and selective estrogen receptor modula

102 , and effects a marked reduction in membrane-impermeant estrogen binding with diminished rapid eNOS a

103 Electroporation has been widely used to load impermeant exogenous molecules into cells.

104 secretory granules combined with the use of impermeant extracellular dyes permits direct observation

105 iphenyl-3-yl ester) as the most potent brain-impermeant FAAH inhibitor disclosed to date.

106 Modelling Mg2+ as an impermeant fast open channel blocker indicated that exte

107 ion of bathophenanthroline sulfonate, a cell-impermeant ferrous iron chelator, inhibited Zip14-mediat

108 Results concerning the uptake of membrane-impermeant fluorescent compounds of various sizes are co

109 ty, as observed using membrane-permeant and -impermeant fluorescent DNA dyes.

110 to a peptide solution containing a membrane-impermeant fluorescent dye (carboxyfluorescein), the pep

111 The membrane-impermeant fluorescent dye, di-8-ANEPPs spread readily f

112 ion was monitored by the influx of Sytox, an impermeant fluorescent dye, into the Env-expressing cell

113 Photoswitches and membrane-impermeant fluorescent dyes likewise penetrate through P

114 ation was achieved by luminally loading cell-impermeant fluorescent dyes selectively into virtually a

115 easurements and confocal imaging of membrane-impermeant fluorescent indicators therefore represent no

116 Using impermeant fluorescent indicators, capacitance measureme

117 be selectively labeled by applying membrane impermeant fluorescent probes to pre-epiboly and mid-epi

118 IBDUs were perfused in vitro with a membrane-impermeant fluorescent volume marker, fluorescein sulfon

119 The membrane-impermeant fluorescent Zn(2+) probe, 6-CO2H-ZAP4, was lo

120 Photoactivation of a membrane-impermeant, fluorescent steroid analog demonstrates that

121 ct cells were assayed with a novel, membrane-impermeant fluorogenic substrate for vp165, we found tha

122 be achieved by choosing membrane permeant or impermeant fluorogens.

123 uolar perforation by LLO, using the membrane-impermeant fluorophore 8-hydroxypyrene-1,3,6-trisulfonic

124 The tubulin-blocked state of VDAC is impermeant for ATP but only partially closed for small i

125 Our data show that membrane-impermeant forms of E2 also activate EC mitogen-activate

126 erminal domain was detected using a membrane-impermeant gel shift reagent to derivatize the Cys resid

127 ns; the effect was also seen with a membrane-impermeant glucocorticoid, but not with intracellular gl

128 g in combination with membrane-permeant and -impermeant Halo dyes allows imaging of integrin endocyto

129 e analogue 3-O-methylglucose (3-OMG), or the impermeant hexitol mannitol-so that the final hexose con

130 The potent activity of the impermeant, highly cathepsin B-specific membrane inhibit

131 enous mouse alpha1A, whereas introduction of impermeant human alpha1A hampered the effect of endogeno

132 48 with the elongated ( approximately 29 A), impermeant hydrophilic reagent maleimide-PEG2-biotin.

133 ol reagent shown clearly in this paper to be impermeant in E. coli spheroplasts, was used to identify

134 ation injury, which can be prevented by cell impermeants in low-volume resuscitation solutions.

135 +)], and [Cl(-)] were measured with membrane-impermeant indicators developed by our laboratory, and p

136 oM in pipette solution), which is a membrane-impermeant inhibitor of phosphatases 1 and 2A.

137 rnal CA is achieved by the use of a membrane impermeant inhibitor that was synthesized for this purpo

138 Similar results are obtained with other cell-impermeant inhibitors of sugar uptake.

139 ective osmotic activity of normally membrane-impermeant intracellular anions.

140 The Woodhull model of channel block by an impermeant ion adequately described the actions of exter

141 of K+, Na+ and most of the Cl- with largely impermeant ions (tetraethylammonium, N-methyl-D-glucamin

142 itute instead of the presumably NMDA channel-impermeant ions N-methyl-D-glucamine (NMDG), Tris or suc

143 The selection of impermeant is important and mannitol is significantly su

144 ion, with a solution containing the membrane-impermeant label propidium iodide.

145 neurons by introducing the charged, membrane-impermeant lidocaine derivative QX-314 through the pore

146 ace binding sites for E2, detectable by cell-impermeant ligand binding and equally with an anti-ERalp

147 is mediated at the cell surface because the impermeant ligand tetramethylammonium was as efficacious

148 cells and membrane preparations by membrane-impermeant ligands indicated that 85% of [3H]epibatidine

149 an external access pathway for the membrane-impermeant local anesthetic derivative QX-222 into the i

150 channels can be also blocked by the membrane-impermeant local anesthetic QX via external paths not pr

151 allowing a significant increase in entry of impermeant low and high molecular weight substances from

152 which, in conjunction with appropriate cell-impermeant macroencapsulation devices, may allow such ce

153 t MRI contrast agents are polar and membrane impermeant, making it difficult to deliver them in suffi

154 comparable to values for the macromolecular impermeant marker inulin in both apical-to-basolateral a

155 tubular fluid-to-plasma concentrations of an impermeant marker TF/P in end proximal tubule fluid were

156 BBB uptake of [14C]sucrose (a membrane impermeant marker) and [3H]codeine were investigated usi

157 t the stage for future human studies of skin-impermeant medications and biopharmaceuticals for clinic

158 TM7 were accessible to hydrophilic, membrane-impermeant methanethiosulfonate (MTS) reagents.

159 Reaction of Cys-90 or Cys-306 with impermeant methanethiosulfonate derivatives enhanced dop

160 he introduced sulfhydryl group with membrane-impermeant methanethiosulfonate derivatives inhibited su

161 the accessibility of Cys148 to either NEM or impermeant methanethiosulfonate derivatives is comparabl

162 nate ethylammonium (MTSEA), but not membrane-impermeant methanethiosulfonate ethyltrimethylammonium (

163 all the reagents tested, including membrane impermeant methanethiosulfonate reagents.

164 Membrane-impermeant methanethiosulfonates (MTS) inhibited bile ac

165 This hydrophilic and skin-impermeant molecule was delivered from a TD patch to hea

166 le to the cys-specific, cytoplasmic membrane-impermeant molecule, Oregon Green(R) 488 maleimide (OGM)

167 The internalization of membrane-impermeant molecules (SYTOX green) with cell viability p

168 ose that PMD, by allowing a flux of normally impermeant molecules across the plasma membrane, mediate

169 to label nerve terminals with large membrane-impermeant molecules after addition of BzATP.

170 derived from the HIV TAT protein to membrane-impermeant molecules has gained wide acceptance as a mea

171 , which was originally used to load membrane impermeant molecules into cells in culture, to load conn

172 During skin penetration, membrane-impermeant molecules of a wide range of molecular weight

173 Loading the interstitial space with cell impermeant molecules prevents water movement into the ce

174 Translocation of membrane-impermeant molecules to the interior of living cells is

175 utward currents that are carried by normally impermeant monovalent cations such as Cs(+) or K(+).

176 entify a limit to accessibility for membrane-impermeant MTS reagents that may reflect aspects of an o

177 Remarkably, studies with small, impermeant MTSES show that single-Cys replacements in th

178 ble toward chemical modification by membrane-impermeant MTSET reagent, strongly suggesting that trans

179 TM1 accessibility to membrane-impermeant MTSET remains confined to the exofacial half

180 +10 mV; replacement of extracellular Na with impermeant N-methyl-D-glucamine decreased its amplitude

181 -maleimide (large, hydrophilic, and membrane-impermeant), N-ethylmaleimide, 4-acetamido-4'-maleimidyl

182 The impermeant nature of the intestinal barrier is maintaine

183 A membrane impermeant neuroactive steroid modulated receptor activi

184 For both O2 and the impermeant nitroxide, the induced relaxation at the stat

185 an inhibitor of NO synthase, and a membrane-impermeant NO donor that releases NO only upon photolysi

186 entry, showed reduced staining with membrane-impermeant nuclear dyes, and failed to replicate.

187 ing target cells resulted in an influx of an impermeant nucleic acid-staining fluorescent dye into th

188 ubation of resealed ghosts with the membrane-impermeant oxidant ferricyanide doubled the ghost membra

189 The membrane-impermeant oxidant taurine monochloramine, however, had

190 Ellman reagent, a membrane-impermeant oxidizing agent which reacts with exposed cys

191 was accessible to inhibition by the membrane-impermeant pCMPS.

192 disulfide isomerase (PDI) and other membrane-impermeant PDI inhibitors prevented HIV-1 infection.

193 transport, IBDUs were perfused with the cell-impermeant pH-sensitive dye BCECF dextran; luminal pH wa

194 e distinguished using membrane-permeant and -impermeant pharmacological CA inhibitors, while measurin

195 enabling the delivery of otherwise membrane-impermeant polar drugs into cells and tissues.

196 Impermeant polymers reduce the conductance in a manner c

197 An impermeant pore mutant abolished BCR-evoked Ca2+ signals

198 Rosiglitazone, a blood-brain barrier-impermeant PPARgamma-selective agonist, elicited antidep

199 Impermeants prevented ischemia-induced cell swelling in

200 ediate access to this region by the membrane-impermeant probe 2-(trimethylammonium)ethyl methanethios

201 accessible from the periplasm to a membrane-impermeant probe in cells with a permeabilized outer mem

202 cellular and can be biotinylated with a cell-impermeant probe.

203 react with both channel-permeant and channel-impermeant probes occupy the outermost extent of TM6 or

204 rom membrane permeant (calcein) and membrane impermeant (propidium iodide) stains.

205 Membrane-impermeant quaternary amine local anesthetics QX314 and

206 Membrane-impermeant quaternary derivatives of lidocaine (QX222 an

207 A membrane-impermeant quencher was used to distinguish intra-PL NBD

208 A membrane impermeant quencher, 2,4,6-trinitrobenzene sulfonic acid

209 The use of a water-soluble membrane impermeant quenching agent in the extracellular space re

210 dized by iron-mediated catalysis to membrane-impermeant quinones and semiquinones.

211 assessed by photolabeling with the membrane-impermeant reagent 2-N-(4-(1-azi-2,2,2-trifluoroethyl)be

212 were sensitive to inhibition by the membrane-impermeant reagent [2-(trimethylammonium)ethyl]-methanet

213 time, and the accessibility of the membrane-impermeant reagent [2-(trimethylammonium)ethyl]methaneth

214 nce after adding the thiol-reactive, bilayer-impermeant reagent methanethiosulfonate ethyltrimethylam

215 to be chemically modified with the membrane-impermeant reagent NHS-biotin.

216 accessible for modification by the membrane-impermeant reagent pCMPS, we hypothesize that eNTPDase3

217 gent N-ethylmaleimide (NEM) and the membrane impermeant reagent polyethyleneglycol maleimide (PEG-mal

218 nt reagent N-ethylmaleimide and the membrane-impermeant reagent polyethyleneglycol maleimide was dete

219 asma membrane proteins were labeled with the impermeant reagent sulfo-N-hydroxysuccinimide-biotin, bo

220 Biotinylation with a membrane-impermeant reagent, separation of the biotinylated/cell

221 GAT-1, but not C399S, very sensitive to this impermeant reagent.

222 n be extracellularly labeled with a membrane-impermeant reagent.

223 de-out vesicles and intact erythrocytes with impermeant reagents and following the outcome by site-di

224 The impermeant reagents MTSES and MTSET react with residues

225 This method allows ready access of otherwise impermeant reagents to the intracellular milieu with min

226 ly diminished after treating cells with cell-impermeant reducing reagents, supporting the presence of

227 within the lipid bilayer, unavailable to an impermeant reporter.

228 thylsulfonate (MTSES) which are permeant and impermeant, respectively.

229 Modelling Ni2+ as an impermeant slow open channel blocker indicated that Ni2+

230 their activity, by introducing the membrane-impermeant sodium channel blocker QX-314 into these axon

231 ity was also probed using Cd(2+), a membrane-impermeant soft metal ion with properties similar to Ag(

232 an be preserved only by a large reduction in impermeant solute concentration within the host cell com

233 hen determined by the intracellular membrane-impermeant solute content (X-i) and its mean charge vale

234 neys and whether this effect is modulated by impermeant solutes included in the preservation solution

235 The effect of impermeant solutes such as NaCl was much less pronounced

236 somes is supplemented with diverse, membrane-impermeant solutes.

237 0% blood volume) with saline or various cell impermeants (sorbitol, raffinose, trehalose, gluconate,

238 serve as filters to exclude anions and other impermeant species from the vicinity of the pore.

239 n of a protein-bound nitroxide by a membrane-impermeant spin relaxant depends on the distance (up to

240 labeled C2cPLA2s and membrane-permeant and -impermeant spin relaxants, we have determined the orient

241 Cytoprotective effects of the cell-impermeant strychnine derivative provide compelling evid

242 inones, and catechol adducts into a membrane-impermeant substance trapped in organelles may provide a

243 zing potency and the penetration efficacy of impermeant substances.

244 sonoporation to deliver calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (

245 from the organism and enhanced access of an impermeant substrate to intracellular alkaline phosphata

246 access of cytosolic ss-galactosidase to its impermeant substrate.

247 other methods and with values for analogous impermeant substrates.

248 re treated in the presence or absence of the impermeant sulfhydryl reagent 4-acetamido-4'-maleimidyls

249 ine potentiated the reaction of the membrane-impermeant sulfhydryl reagent methanethiosulfonate ethyl

250 s, the inhibition of transport by a membrane impermeant sulfhydryl reagent was diminished under condi

251 lity of an endogenous cysteine to a membrane impermeant sulfhydryl reagent was enhanced by the D451E

252 an endogenous cysteine residue to a membrane-impermeant sulfhydryl reagent was increased relative to

253 the reactivity of the mutants to a membrane-impermeant sulfhydryl reagent was not conformationally s

254 ibited by an externally applied and membrane-impermeant sulfhydryl reagent.

255 Cytoplasmically applied membrane-impermeant sulfhydryl reagents alter the Ca2+ sensitivit

256 s probed with membrane-permeant and membrane-impermeant sulfhydryl reagents under a variety of condit

257 o acids to extracellularly applied, membrane-impermeant sulfhydryl reagents.

258 bbeta3, platelets were labeled with membrane-impermeant sulfhydryl reagents.

259 ed by mutagenesis and probed with a membrane-impermeant sulfhydryl-labeling reagent.

260 or C11A mutant secretin receptor with a cell-impermeant sulfhydryl-reactive reagent.

261 hibition of transport activity by a membrane-impermeant sulfhydryl-specific reagent (p-chloromercurib

262 steine-scanning mutagenesis and the membrane-impermeant sulfhydryl-specific reagent, p-chloromercurib

263 incubation of oocytes in the presence of the impermeant sulfhydryl-specific reagent, p-chloromercurib

264 ing and rapid derivatization with a membrane-impermeant, sulfhydryl-specific gel-shift reagent.

265 The modifying reagents, two membrane-impermeant, sulfhydryl-specific methanethiosulfonate der

266 ent-accessibility studies using the membrane-impermeant, sulfhydryl-specific methanethiosulfonate rea

267 eine accessibility method using the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

268 eine accessibility method using the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

269 mutagenesis in conjunction with the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

270 mutagenesis in conjunction with the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

271 mutagenesis in conjunction with the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

272 eine accessibility method using the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

273 hypoxia, an activity which is suppressed by impermeant sulfonamide CA inhibitors.

274 cell monolayer and introduces the ability of impermeant therapeutic agents including high molecular w

275 e use of mass spectrometry with permeant and impermeant thioimidates promises insights into the membr

276 essibility method analysis with the membrane-impermeant thiol reactive reagent p-chloromercuribenzene

277 accessibility of S4 residues to the membrane-impermeant thiol reagent methanethiosulfonate-ethyltrime

278 Methanethiosulfonate ethylsulfonate, an impermeant thiol reagent shown clearly in this paper to

279 fonate ethylsulfonate (MTSES), a hydrophilic impermeant thiol reagent, show that most of the position

280 slocation pathway, that the accessibility to impermeant thiol reagents is influenced (blocked or stim

281 blockage of [14C]NEM labeling with membrane-impermeant thiol reagents such as methanethiosulfonate e

282 cted thiols demonstrated with detergents and impermeant thiol reagents suggests that the protein may

283 ity toward both channel-permeant and channel-impermeant thiol-directed reagents, and patterns of reac

284 in the presence and absence of the membrane-impermeant, thiol-reactive agent p-chloromercuribenzosul

285 o identify wound-associated proteins, a cell-impermeant, thiol-reactive biotinylation reagent was use

286 ine-substituted channels in conjunction with impermeant, thiol-reactive reagents like MTSET+ and MTSE

287 y of TM11 single-cysteine mutants, using the impermeant, thiol-specific reagents, carboxyethyl methan

288 d to the outer leaflet of membranes that are impermeant to dithionite.

289 lungs were filled with liquid containing an impermeant tracer to allow estimation of net liquid move

290 lungs were filled with liquid containing an impermeant tracer, to allow measurement of the rate of n

291 demands both the coinjection of permeant and impermeant tracers followed by the examination of sectio

292 When Na+ was replaced with the impermeant Tris the transducer current increased with ex