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1 help intervenes and where therapeutic agents impinge.
2 nsformation until the directed growth fronts impinge.
3 to an ion optical element upon which photons impinge.
4             Similar experiments performed by impinging a C (16)O beam on a Au(111) surface covered wi
5  without external electromagnetic action, by impinging a high-speed microjet of deionized water on a
6  conditions in biofilms are dependent on the impinging aqueous solution, chemical diffusion, and the
7 drites, the region forming synapses with the impinging axons of Schaffer collateral.
8 quite general for all anisotropic fluids and impinge broadly on their quantitative studies using lase
9            However, GSK3 and mTOR inhibition impinge differently and independently on TFEB phosphoryl
10 ed in regulating the homeostatic system also impinge directly on dopamine neurons; for example, lepti
11 d suggest that eosinophil effector functions impinge directly on lung function.
12 provides a mechanism for metabolic status to impinge directly on the cellular decision of whether to
13 the CAA contains GABAergic interneurons that impinge directly onto SPNs to inhibit their activity and
14                          Activation of Notch impinges directly on gene expression through the Suppres
15 ing energetics and diffusional domain motion impinges directly on the molecular recognition of cytoch
16 switches (PMPs) that selectively harvest the impinging electromagnetic energy in design-defined spect
17                 A small fraction (>~0.1%) of impinging electrons are captured at the edge of 2D hole
18 to insulate facultative heterochromatin from impinging euchromatin to produce discrete positional ide
19                                          The impinging flow device provides a, to our knowledge, nove
20                                  We built an impinging flow device that exposes endothelial cells to
21                   In this study we show that impinging gas-phase CO molecules react readily with oxyg
22 The predominately fast neutrons generated by impinging high-energy electrons onto a tantalum converto
23 etry with hydrodynamic flow consisting of an impinging jet in a wall-tube configuration.
24                                          The impinging jet is designed in a wall-tube configuration,
25 le (energy barrier present) conditions in an impinging jet system.
26  been studied using EW-CRDS combined with an impinging-jet to deliver analyte to the surface in a wel
27 maging demonstrate that flow in the MJE, and impinging jets in general, are more complex than predict
28 ring" formed from an oil-rich layer of water impinging laterally upon the continental slope (at a dep
29 ices where active all-optical control of the impinging light can be achieved.
30 teract with the spin angular momentum of the impinging light field.
31          In traditional photoconductors, the impinging light generates mobile charge carriers in the
32 , thereby highlighting the flow field of the impinging microjet.
33 bus formation are not necessarily those that impinge most on the lumen of the vessel.
34 ity and angular distributions imply that all impinging Na atoms that thermally equilibrate on the sur
35            Both iron deficiency and overload impinge negatively on cardiac health.
36 ynapses change their strength in response to impinging neural activity is a fundamental issue for und
37  the particles enter the source region, they impinge on a cartridge heater and are vaporized.
38 rmal cells; however, the immune signals that impinge on actin cytoskeleton and its response regulator
39  findings demonstrate that peripheral inputs impinge on an internally organized network, which provid
40 idative species are carried by the spray and impinge on and react with the sampled analyte during des
41 of action or the nature of the pathways they impinge on are poorly understood.
42                  Thus, T reg cells primarily impinge on autoimmune diabetes by reining in destructive
43 imicrobial peptides, cytokines and hormones) impinge on bacterial infections and regulate immune resp
44 lating function, glycan-protein interactions impinge on biological functions in a more 'analog' fashi
45 l need to be carefully evaluated as they may impinge on bone metabolism.
46 tion or behaviour, they can also interact to impinge on both processes.
47 stresses generated by the applied fluid flow impinge on cell contractility to drive the stem cell dif
48 rs function in normal tissue homeostasis and impinge on critical aspects of disease progression and r
49 that they can be locally infiltrative and/or impinge on critical organs, which leads to disfigurement
50 er of cellular proteins that are expected to impinge on diverse biological processes.
51  imbalances in Neuregulin-ErbB signaling can impinge on dopaminergic and glutamatergic function, neur
52 light how independent signaling pathways can impinge on each other at the level of transcription fact
53 They determine supercurrents in superfluids, impinge on electrooptical switching in polymer-dispersed
54 pies, collectively termed endocrine therapy, impinge on estrogen-induced ERalpha activation to block
55 ack of precision of PC firing, that may also impinge on GC activity and requires expression of two du
56  current view of how mitochondrial functions impinge on health and disease.
57 ine how chronic inflammatory processes might impinge on hematopoiesis, potentially fostering hematopo
58 ation of I(1,4,5)P3 metabolic pools directly impinge on higher IP synthesis, and that the major route
59 cyte interactions (phagocytic synapses) that impinge on host immunity, with a main emphasis on tolera
60 th special emphasis on how stress conditions impinge on insulin/insulin-like growth factor signaling/
61 ontributions and their retinal circuits that impinge on ipRGCs are not well understood.
62 passively waiting for nociceptive stimuli to impinge on it but is actively making inferences based on
63 nce of excitatory and inhibitory inputs that impinge on it.
64 ther post-translational modifications of Bak impinge on its activation potential.
65 ve endocytosis of both types of particle may impinge on lipid as well as mineral debris clearance in
66       To investigate how prefrontal cortices impinge on medial temporal cortices we labeled pathways
67 lators in response to a host of factors that impinge on metabolism and would otherwise destabilize th
68 diversity of signals that have been shown to impinge on mTOR, we also speculate on other signal-trans
69 tics for gas-phase O3, NO3, and OH when they impinge on organic surfaces.
70 alB depletion, suggesting that RalA and RalB impinge on overlapping transcriptional signaling pathway
71  activate a wide variety of brain areas that impinge on parasympathetic neurons innervating the menin
72 nd the fiscal and macroeconomic factors that impinge on pay policy for the public sector.
73 ough which alterations in diurnal activities impinge on peripheral circadian clocks (PCCs), and recip
74 d transforming effects across platforms that impinge on plant health and public health.
75 nction in atherosclerotic plaques and, thus, impinge on plaque growth and stability.
76                       The ability of UPF1 to impinge on premature termination, moreover, requires ATP
77             How signal transduction pathways impinge on proteins modulating P-body and stress granule
78 y biological reactions at shores where waves impinge on rocks and bring nutrients periodically.
79  survival and cell migration that ultimately impinge on several hallmarks of cancer, including increa
80 er the pathways that control organ size also impinge on stem/progenitor cells.
81 g nervous system; however, how these factors impinge on surface molecules that control guidance decis
82 acid substitutions disrupting these contacts impinge on the ability of the intasome to engage nucleos
83  to investigate whether such linkage effects impinge on the ability of the McDonald-Kreitman (MK) tes
84 es that predicted human receptor binding and impinge on the antigenic characteristics of the HA.
85        Pathway terminals in the upper layers impinge on the apical dendrites of neurons in other laye
86 ation of a pinched liposomal funnel that may impinge on the apparently unperturbed viral envelope.
87  how the capsid-stabilizing functions of mu1 impinge on the capacity of mu1 to undergo conformational
88 disparate signaling pathways that ultimately impinge on the cellular mechanisms regulating gene expre
89 thesis, heat shock proteins and antioxidants impinge on the complexity of HTS-induced responses over
90 egration of numerous signaling pathways that impinge on the cytoskeleton.
91  peripheral tolerance mechanisms selectively impinge on the diabetogenic potential of high-affinity T
92 RNAs (lncRNAs) are a class of molecules that impinge on the expression of protein-coding genes.
93 response to changing growth conditions could impinge on the HDM2-p53 pathway by interrupting the inte
94 e the axon terminals of GABAergic cells that impinge on the initial axon segments of excitatory pyram
95                            How specific TRCs impinge on the innervating nerves and how the activation
96 ion from innate to adaptive immunity and may impinge on the interaction of Mycobacterium tuberculosis
97 on of progenitor cell potential can directly impinge on the maintenance of homeostasis and contribute
98 nal macroelectrode Clark electrode, does not impinge on the membrane.
99                          The Hck SH2 domains impinge on the N-terminal region of Nef to stabilize a d
100 n levels can act at multiple sites and thus, impinge on the overall activity of a distributed network
101                   However, how the mutations impinge on the p97-cofactor interplay is unclear so far.
102 es two antiapoptotic signaling pathways that impinge on the proapoptotic protein BAD.
103 hibitor of Src tyrosine kinases, was used to impinge on the proapoptotic signaling pathway activated
104 terestingly, Pho regulon expression does not impinge on the rate of attachment to a surface but rathe
105 upon virus infection and that these clusters impinge on the stimulatory capacity of the APC.
106 ure to identify important factors which will impinge on the successful integration of VR training int
107 angled outwards so that the exhaust does not impinge on the surface.
108 ng that disruption of the Slug-Puma axis may impinge on the survival of metastatic cells.
109 ntal and physiological factors were shown to impinge on the transcription of the car biosynthetic gen
110                           MicroRNAs (miRNAs) impinge on the translation and stability of their target
111 and angiogenic growth factor-induced signals impinge on the vascular endothelial cadherin (VE-cadheri
112 ying enzymes and the signaling pathways that impinge on them in the settings of pathological cardiac
113 rotic lesion, the extracellular factors that impinge on these cells, and the intracellular mechanisms
114 lth and homeostasis; injury or diseases that impinge on these components frequently cause pathologic
115         However, the signaling pathways that impinge on these molecular switches remain poorly unders
116                 Natural and sexual selection impinge on these processes, yet our understanding of beh
117 ng as an adaptor molecule that allows Src to impinge on these processes.
118 induce haploid embryo development in culture impinge on this HDAC-dependent pathway.
119      However, the nature of the signals that impinge on this pathway and the role of Baf60c in glucos
120 ting autoantibodies, suggesting that UNG may impinge on tolerance.
121        I review how these signaling pathways impinge on transcriptional, metabolic, and developmental
122 d phospholipid metabolite profile that would impinge on tumor pathobiology.
123 eins and pathways of pharmaceutical interest impinge on ubiquitin ligases or their substrates.
124  hepatitis C virus (HCV) persistence and can impinge on vaccine development.
125                   Activation of Aurora A can impinge on YAP activity through direct phosphorylation.
126 orylation status at these two sites directly impinged on asymmetric segregation of Numb in mitotic ne
127 o7 counterpart, PCID1 (also known as EIF3M), impinged on caspase 9, revealing a new regulatory axis a
128                            In addition, Eya2 impinged on G protein-mediated signaling, as evidenced b
129 s resembling tertiary lymphoid organs (TLOs) impinged on lymphatic collecting vessels that enter and
130 dation of carbon monoxide, if a C (16)O beam impinges on a Au(111) surface covered with both atomic o
131 oworkers showed that when an ultrafast laser impinges on a ferromagnet, its spin moment undergoes a d
132 rojection neurons, whereas much of the input impinges on a heterogeneous population of interneurons i
133 echanism controlling MTSS1 expression, which impinges on a pro-tumorigenic role of MTSS1 in breast tu
134  novel mechanism in which a nuclear receptor impinges on a signaling pathway by co-opting protein kin
135   To investigate how ITIM receptor signaling impinges on activating pathways, we developed a photoche
136 eal (ER) and hot atom (HA) mechanisms when H impinges on adsorbed CO2, and we show that both occur ev
137       Circadian (approximately 24 h) control impinges on an array of diverse physiological processes
138 d minus-end spacing, is regulated and how it impinges on axonal transport are unclear.
139 e a tool to explore novel means whereby CREB impinges on brain functions requiring adaptive, long-las
140 en localized exclusively at the ER, Bcl-x(L) impinges on Ca(2+) homeostasis but does not affect apopt
141 ammalian CK counterpart, MYO7A, binds to and impinges on CASPASE-8, revealing a new regulatory axis a
142 nteractions at the ER with the InsP(3)R that impinges on cellular Ca(2+) homeostasis.
143 en, suggesting that the extracellular matrix impinges on cellular function, possibly through an Akt-m
144 dant monounsaturated omega-9 fatty acid that impinges on different biological processes, but the mech
145 dimer partners of these specific factors and impinges on differentiation.
146 that p27(kip1), by controlling MT stability, impinges on H-Ras trafficking and ubiquitination levels,
147 meliorates liver injury induced by Con A and impinges on hallmarks of NKT cell activation in the live
148 nalyses also demonstrate that MLL4 primarily impinges on hepatic BA production among several regulato
149 disease in chronically infected individuals, impinges on host apoptotic pathways in a cell type-depen
150 uned to higher frequencies when the stimulus impinges on large regions of the sensory epithelium.
151 ) where a significant decline in cell height impinges on microtubule spindle function, thereby inhibi
152 at EGF signaling, acting through MAP kinase, impinges on multiple aspects of Ind regulatory activity.
153                      We find that PAR-4/LKB1 impinges on myosin via two pathways, an anillin-dependen
154 trate that pathological PS1 loss-of-function impinges on neurite formation through a selective APP ga
155 e ATF4 dosage impacts cell cycle control and impinges on neurogenesis.
156 rons and nonneuronal cells, mutation of path impinges on nutrient responses and protein homeostasis s
157  little is known as to how this modification impinges on other chromatin activities.
158 ression, the mechanism through which SWI/SNF impinges on RB action is unresolved.
159             The USP8.STAM complex critically impinges on receptor ubiquitination status and modulates
160 n ethylene and salicylic acid signaling that impinges on senescence and cell death.
161  the regulation of MT stability by p27(kip1) impinges on signaling pathway activation and contributes
162 ts via an A2B receptor-mediated pathway that impinges on specific potassium channel effectors.
163                            In response, AMPK impinges on the autophagy regulators Unc-51-like kinase-
164  that TSC1-mediated control of mTOR activity impinges on the balance between immunity and tolerance b
165  reveals that the branched side-chain of L10 impinges on the benzene ring of Y11 so as to constrict i
166  hypothalamic-midline thalamic-striatal axis impinges on the cholinergic interneurons of the striatum
167 where material from subducting oceanic slabs impinges on the core-mantle boundary, using shallow as w
168 nction studies have demonstrated that PTPN22 impinges on the homeostatic behavior of regulatory T (Tr
169 may be driven by increased inflammation that impinges on the IR and IRS-1 signaling cascade in skelet
170 ional important regulatory modification that impinges on the mechanisms underlying mTORC1-dependent S
171 e subarachnoid space within the orbit, which impinges on the optic nerve and/or eye in affected indiv
172                               The sample air impinges on the plate via an entrance nozzle.
173 are obtained when circularly polarized light impinges on the reflective-type metasurface positioned o
174  in calcium to the production of cAMP, which impinges on the regulation of many aspects of neuronal f
175         However, the mechanism by which Six1 impinges on the TGF-beta pathway was, until now, unclear
176 ue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes
177 ternally through a phosphorelay circuit that impinges on the transcription of multiple small regulato
178                          Photosignaling also impinges on the transcriptional regulation response esta
179  was examined to determine whether Nischarin impinges on these other Rac1 effector pathways.
180                                      Aspirin impinges on these systems, triggering formation of the e
181           Mechanistically, we show that ERK5 impinges on transcription factor NFATc4.
182              In studies of gas-phase H atoms impinging on a CO-adsorbed Ni(110) surface, Born-Oppenhe
183 n influence cell differentiation status when impinging on a key node in the regulatory network that g
184 from ultrasound passing through a liquid and impinging on a liquid-gas interface) is the basis for ul
185 amework for antiangiogenesis signaling, thus impinging on a myriad of pathological conditions that ar
186 to the bidirectional ability of all synapses impinging on a neuron to actively compensate for changes
187 ally refracted P-wave, arising from a P-wave impinging on an interface between two VTI media with str
188 trinsic and extrinsic pathological stressors impinging on cellular viability.
189 line in the extent of oxygen-depleted waters impinging on continental shelves and platforms.
190                     Here we show that a drop impinging on Echevaria leaves exhibits asymmetric bounci
191 es by performing FM4-64 imaging in terminals impinging on enhanced green fluorescent protein (eGFP)-l
192 s, including ErbB and FGF signaling pathways impinging on fMaSC growth.
193 (NRP2) controls EGFR protein levels, thereby impinging on intracellular signaling, viability, and res
194 of electrons generated by one UV laser pulse impinging on multiple, spatially distinct, cathode surfa
195 tified key signaling pathways, with examples impinging on MYC activity.
196 coordinated expression of a cluster of genes impinging on neuronal activity, providing a tool for stu
197  pattern modulated the size of unitary EPSPs impinging on NGFCs through FSI and not via a direct effe
198 y wave-steering capability for incident wave impinging on one side, while virtually blocking the reve
199 om proliferation to differentiation, thereby impinging on postembryonic growth capacity of the root m
200  by activating all dopamine neuron terminals impinging on recorded neurons with wide-field photostimu
201                               Retinal spikes impinging on relay neurons in the lateral geniculate nuc
202  strengthening from blockage of dislocations impinging on TBs, coupled with the 3D twin network which
203 ly expand our knowledge of regulatory inputs impinging on the Abca1 promoter and indicate a central r
204 on of the myosin light chain kinase, thereby impinging on the actomyosin contractility required to ge
205 damentally a problem in signal transduction, impinging on the altered expression or function of gene-
206 local heating of the electronic distribution impinging on the ballistic junction.
207 hould only carry crystal momentum and, while impinging on the cluster, should not be able to impress
208  also unraveled a speciogeographic variation impinging on the compositional fingerprint that may modu
209 I isolate at least two environmental factors impinging on the consumer organism that may determine wh
210 zone of euxinic (anoxic and sulfidic) waters impinging on the continental shelf and sandwiched within
211 ade of approximately 10(6) electrons per ion impinging on the conversion dynode.
212 ion of a higher order chromatin conformation impinging on the CTCF-XIST promoter complex.
213 vant inputs from among thousands of synapses impinging on the dendritic tree.
214 thereby preventing neutral contaminants from impinging on the deposition surface.
215 ed by liquid emerging from a circular nozzle impinging on the disk under wall-jet conditions.
216  experience, the majority of the information impinging on the eye is lost.
217 gets to prevent the disease without directly impinging on the host defense.
218 rigger a cascade of neurotoxicity critically impinging on the integrity of the actin cytoskeleton.
219 verall, these studies showed that activities impinging on the LBD regulate GR exchange with GREs but
220 patient to learn associations between events impinging on the limb and arbitrary sensations.
221                                           On impinging on the lithosphere at spreading ridges or in i
222 ins as novel and positive HSPC regulators by impinging on the LNK/JAK2 pathway.
223           The negative regulatory mechanisms impinging on the N-terminal domain are poorly understood
224  and is caused by early spindle microtubules impinging on the NE.
225 formations than those caused by microtubules impinging on the NE.
226  new flagellum so that it can extend without impinging on the old flagellum.
227 he saccade/fixation cycle reformats the flow impinging on the retina in a way that initiates coarse-t
228 to reduce the kinetic energy of the Au atoms impinging on the surface (buffer layer assisted growth o
229 tes the outcome of TBI in mouse, by directly impinging on the toxic pathway activated in response to
230 icted clearly demarcated subcortical lesions impinging on the white matter tracts of interest; howeve
231  known about the upstream signaling pathways impinging on transcription to ultimately regulate ABA co
232 inflammation brought on by ER stress without impinging on UPR-dependent survival and adaptive respons
233 arborizations of L3 cells, individual inputs impinged onto distinct single domains.
234 ence-dependent reorganization of connections impinging onto adult-born neurons, which is likely to ha
235 ding to an enhancement of GABAergic activity impinging onto CA1 pyramidal neurons that could be reduc
236                                     Circuits impinging onto layer 2/3 neurons from layers 4 and 2/3 d
237                   The temporoammonic pathway impinging onto the CA1 distal apical dendritic tuft is t
238 el vocal production mechanism: a glottal jet impinging onto the laryngeal inner planar wall.
239 s incessantly modulate the luminance signals impinging onto the retina during natural intersaccadic f
240 on, can be controlled by the polarization of impinging optical signals, realizing the notion of 'ster
241         At steady state, over one-quarter of impinging oxygen molecules undergo dissociative adsorpti
242 is the pressure generated by the momentum of impinging photons.
243 trated that increased GABA synaptic activity impinges principally on indirect pathway MSNs.
244  to cocaine continues, the impact of cocaine impinges progressively on the processing of sensorimotor
245 ting in efficient induction of apoptosis and impinged proliferation.
246 pproximately 15,000 elementary visual inputs impinging retinotopically onto the LGMD's dendritic fan
247 audible frequencies, which fully absorbs the impinging signal, without at the same time perturbing it
248  network that amplifies small changes in the impinging signals and emerges automatically from learnin
249 ne responsiveness to EphB is regulated by co-impinging signals from other axon guidance molecules.
250 y modifying the direction or polarization of impinging signals.
251 first steps of photosynthesis, the energy of impinging solar photons is transformed into electronic e
252 ences in the timing (ITD) and level (ILD) of impinging sounds carry critical information about source
253 18)F-FDG-avid lesions not only were found in impinged spinal nerves but also were associated with non
254 at the transition state is compressed by the impinging steric bulk of the nucleophile and leaving gro
255               Additionally, SAPP was able to impinge the ability of P. gingivalis to dysregulate inna
256 mutations in four conserved assembly factors impinging the biogenesis of the mitochondrion-encoded ca
257 lets on a MALDI target plate with matrix and impinging the laser directly on the dried islet.
258 he epithelial-mesenchymal transition program impinge their biological functions during tumor metastas
259 lso influenced by environmental effects that impinge uniquely on children from the same family.
260 ls, we discover that MAPK pathway inhibition impinges uniquely on this event, indicating distinct sus
261 nhibit store-operated Ca(2+) entry (SOCE) to impinge upon airway secretions, leaving females at great
262  impact lung and cardiovascular disease also impinge upon CNS health.
263 he mechanisms by which environmental signals impinge upon microtubule organization and whether microt
264 te sensing activates signaling pathways that impinge upon molecular, metabolic, physiological, and de
265                      Many of these functions impinge upon oncology by influencing the efficacy and to
266 ctivated by extrinsic mitogenic signals that impinge upon p27 at the earliest stage of cell division.
267 n local brain regions suggests that they may impinge upon physiological and pathological elements tha
268 elated metabolic abnormalities are likely to impinge upon SIRT1 functioning.
269  that genetic and environmental risk factors impinge upon systems-level circuits for several core dim
270 ur findings further suggest that agents that impinge upon TCR signaling may represent an effective th
271 nt huntingtin with multiple opportunities to impinge upon the broader machinery that orchestrates dev
272    These results indicate that HIV-1 Gag can impinge upon the functioning of the cellular vacuolar pr
273 ation, and spine deformation that ultimately impinge upon the paired signal output domains.
274 ely little known about how metabolic factors impinge upon the pathogen's well-characterized cascade o
275 acterized a novel point at which Rho GTPases impinge upon the regulation and function of MEKK1.
276 road spectrum of environmental energies that impinge upon the skin has rested on inference and conjec
277 omplex 1 pathway and on how various stresses impinge upon them.
278 tibiotics, such as kanamycin, and polyamines impinge upon this circuit.
279 k induces multiple cellular alterations that impinge upon transport efficiency.
280 how host, commensal, and cellular metabolism impinge upon Treg homeostasis and function.
281 ta signaling and its downstream effects that impinge upon tumor growth in ovarian cancers.
282 include Pik1p/PtdIns(4)P, TRAPPII and Gyp2p, impinge upon Ypt31 signaling to regulate Golgi secretory
283  annular stimuli that encircled--but did not impinge upon--the RFs of the recorded cells.
284 ase in which maxillary central incisors were impinged upon by a broad aberrant frenum, probed </=3 mm
285 Solid tumor metastasis is a complex biology, impinged upon by a variety of dysregulated signaling pat
286 enin was activated in several cell types and impinged upon the viability of these mice, it was not po
287                   Therefore, in T cells, Akt impinges upon NF-kappaB signaling through at least two s
288 as and their scope of practice, which likely impinges upon patients' access to care.
289 nsistent manner, and that this inconsistency impinges upon the ability to relate phonology and orthog
290                  These data suggest that Dop impinges upon the initiation of furrow formation through
291  means that when a relevant sensory stimulus impinges upon the system, it will encounter preestablish
292                                 This pathway impinges upon various organ primordia to instruct their
293  cortical and thalamic glutamatergic signals impinging upon principal medium spiny neurons (MSNs) of
294 CB(1) receptors in inhibitory-type terminals impinging upon principal neurons within layer V of the p
295                   Environmental oscillations impinging upon the ear are generally thought to be proce
296 o be processed independently of oscillations impinging upon the skin.
297 man standard- and immuno-proteasomes thereby impinging upon total degradation rate and substrate clea
298 urotransmission blockade in vitro as well as impinging vibrissal sensory drive in vivo.
299 terials promote dropwise condensation, repel impinging water droplets, and sustain hydrophobicity eve
300 ration, or convolution) on the profile of an impinging wave as it propagates through these blocks.

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