ライフサイエンスコーパス: implicate @2 in

1 ata, current estimates derived from modeling implicate pertussis in 1% of under-5 mortality, with inf

2 In 2 patients, drugs and viruses could be implicated, and in 1 patient may have hidden or triggere

3 tudies in individuals or small kindreds have implicated rare variants in 25 different genes in lone a

4 The data implicate 12-HETER1 in a critical new role in the regula

5 Our data also implicate NCX-9 in a LON-2/heparan sulfate and UNC-6/net

6 Our results implicate RFT1 in a wider range of glycosylation process

7 l and genetic analyses of these SH3 partners implicate them in a range of activities that ensure the

8 However, recent studies implicate TRBP in a variety of biological processes as a

9 Our results implicate vinculin translocation in a molecular switchin

10 peptide-specific cytotoxic CD8+ T cells are implicated as effectors in a transgenic mouse model of a

11 or sleep debt per se does not, as previously implicated, result in a deleterious metabolic phenotype.

12 tent with this, there is increasing evidence implicating chloride in a range of neurological conditio

13 tion, reflected by a flood of recent studies implicating SUMO in a wide range of cellular and molecul

14 A large body of research exists implicating trehalose in a variety of cellular phenomena

15 Although genetic studies have implicated autoimmune processes in AA etiology, understa

16 t of ESCRT-III to the cytokinetic bridge and implicates ALIX in abscission checkpoint signaling.

17 ria monocytogenes actin comet tails, thereby implicating it in actin assembly.

18 Genetic associations in humans have implicated AP activation in age-related macular degenera

19 A growing body of recent evidence, however, implicates FMOs in aging, several diseases, and metaboli

20 Collectively, our data implicate Cdk5 in allogeneic T-cell responses after HCT

21 I phosphorylation of the RALB effector TBK1, implicating RALB signaling in AML relapse.

22 pe 3 innate lymphoid cells (ILC3s) have been implicated, respectively, in asthma and adipose tissue h

23 ted between virulent and avirulent isolates, implicating its role in attenuation.

24 pattern for each specific MMP was observed, implicating them in axonal regrowth and inner retina rem

25 l Bax transmembrane domain interactions were implicated recently in Bax pore formation.

26 Taken together, these results implicate a reduction in BDNF-TrkB signalling in the dmN

27 derlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective

28 CAD heritability and identify 243 loci that implicate pathways in blood vessel morphogenesis as well

29 Recent studies have implicated epigenetic remodeling in brain reward regions

30 between the Hippo and Wnt pathways has been implicated recently in breast cancer development, but ke

31 ncovered in the mutant screens have not been implicated in respiration in budding yeast.

32 UP37, NUP43, and NUP188, which have not been implicated previously in cardiac disease.

33 mice and support accumulating evidence that implicates nitrosative stress in cardiac and muscle dise

34 loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and str

35 size, and depressed cardiac function, newly implicating MerTK in cardiac repair after myocardial isc

36 -associated genes are severely misexpressed, implicating a defect in cell wall formation during tip g

37 ic defects with dipM, ftsE and amiC mutants, implicating FzlC in cell wall hydrolysis.

38 Pathway analysis implicates splicing in cellular PRMT5 dependency, and we

39 This apparent occlusion effect implicates reduction in chloride extrusion as a mechanis

40 s the still-limited literature that directly implicates epigenetic modifications in chronic pain synd

41 to B-cell-specific regulatory elements, thus implicating this oncogene in CLL development.

42 Recent studies have implicated TH signaling in cone photoreceptor viability.

43 A) signaling leads to vessel overexpansion, implicating actomyosin contractility in control of lumen

44 Our results also implicate phosphorylation cycles in controlling SNAP23 S

45 These results implicate Ub signaling in coordinating RNA processing by

46 is regulated by copper availability, further implicating it in copper delivery to Cox2.

47 cilia-driven CSF flow in spine development, implicate irregularities in CSF flow as an underlying bi

48 iosensor and potentiates glucose metabolism, implicating rises in cytoplasmic Ca(2+) as a critical re

49 ent sensing and the DNA damage response, and implicated Vts1 in de novo gene "birth." TGA provided si

50 These findings implicate indole glucosinolates in defense against paras

51 A chromosome duplication implicated FtsA overproduction in Deltapbp2b suppression

52 d the cytoplasmic DNA sensor cGAS and STING, implicating this pathway in dendritic cell activation.

53 Although earlier research implicated cellular immunity in dengue immunopathogenesi

54 Increasing evidence implicates epigenetic mechanisms in depression and antid

55 ts are consistent with more recent proposals implicating the claustrum in detecting sensory novelty o

56 ical rodent studies during the last 20 years implicated glutamate neurotransmission in different brai

57 vated microglia surrounding amyloid plaques, implicating their role in disease pathogenesis.

58 y components of the proteostasis network and implicate autophagy defects in diseases with compromised

59 nome are susceptible to genetic instability, implicating them in diseases.

60 ade activation and fibrin deposits have been implicated or observed in diverse forms of liver damage.

61 Recent studies have implicated changes in DNA methylation and small RNAs in

62 Recent evidence implicates epigenetic mechanisms in drug-associated memo

63 Based on these findings, we securely implicate PPP3CA in early-onset refractory epilepsy and

64 In vitro studies implicate BRCA1 in elimination of R-loops, DNA-RNA hybri

65 Overall, the findings implicate the IFC in emotion processing and demonstrate

66 ishes nonrandom inhibitory connectivity, and implicates this patterning in encoding specific features

67 ication, we studied the role of C4, recently implicated in schizophrenia, in engulfment of synaptic s

68 These data implicate versican G1 in enhancing adenoviral vector tra

69 These findings implicate mutations in ESRP1 as a cause of SNHL and demo

70 ls in the DCN and abolishes zinc inhibition, implicating zinc in experience-dependent AMPAR synaptic

71 Based on previous studies implicating changes in extracellular matrix remodeling i

72 armacological administration of oxytocin has implicated this neuropeptide in face perception and soci

73 acial expressions in nine-month-old infants, implicating this system in facial expression processing

74 tions cause Weill-Marchesani syndrome (WMS), implicating it in fibrillin microfibril biology since so

75 n, consistent with previous biochemical data implicating NAIP6 in flagellin detection.

76 g these relationships shifted from baseline, implicating changes in gait signatures, but with marked

77 ong-range and local epigenetic environments, implicating these sites in gene regulation and chemother

78 These results implicate additional mechanisms in generating directiona

79 ditis elegans and in chondrogenic cell lines implicated variants in genes necessary for transcription

80 AR domain, demonstrating that the BAR domain implicates OPHN1 in granule membrane recapture after exo

81 Metabonomic studies implicated variations in gut microbial activities that m

82 e the origins of gHAT epidemics and evidence implicating human genetics in HAT epidemiology.

83 Thus, the data presented here implicate endocytic pathways in HCMV maturation and egre

84 Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and hi

85 Previous work has implicated spontaneous neurotransmission in homeostatic

86 The top signal resided in GREB1L, a gene implicated previously in Hoxb1 and Shha signaling in zeb

87 priate activation of PI3K signaling has been implicated strongly in human cancer.

88 evelopment as well produce countless studies implicating these elements in human disease.

89 the role of two brain regions that have been implicated in MDD in humans, the infralimbic prefrontal

90 te sensitivity of the striatum to IFN-alpha, implicate striatal perturbation in IFN-alpha-induced fat

91 ic studies have provided convincing evidence implicating alterations in immune/inflammatory processes

92 Although previous work implicated the CeMA in incentive salience, our results i

93 in the CSF levels of soluble TREM2 fragments implicate changes in inflammatory pathways as occurring

94 Recent studies implicate TonEBP signaling in inflammatory disease and r

95 cells in response to P. gingivalis, thereby implicating TLR9 in inflammatory responses to this organ

96 clinical, genetic, and functional data that implicate HARS mutations in inherited peripheral neuropa

97 acellular H2O2 in the colonic epithelium and implicate AQP3 in innate immunity at mucosal surfaces.

98 ptor MRGPRX1 and the mouse homolog MrgprC11, implicated previously in itch.

99 Conflicting hypotheses implicate awake replay in learning from reward and in me

100 oto-oncogenes and receptor tyrosine kinases, implicating these events in lethal transitions.

101 Taken together, these findings implicate Rpn13 in linking parkin to the 26 S proteasome

102 ced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites.

103 Genetic association studies implicated variants in loci harboring haptoglobin-relate

104 etacean liver under hypoxic conditions, thus implicating FGF23 in low bone density in cetaceans.

105 roduction of IFN-gamma and IL-17A/F, further implicating SHP2 in lupus-associated immunopathology.

106 Finally, we present data implicating Prosapip1 in mechanisms underlying alcohol s

107 These data implicate GM3 in mediating glucose-induced suppression o

108 Recent studies implicate ROS generation in mediating inflammatory and a

109 These data implicate sex differences in microglial activation in th

110 Recent studies have implicated chemokines in microglial activation and patho

111 Sensory preconditioning has been used to implicate midbrain dopamine in model-based learning, con

112 g-Gly-Asp-peptide affinity and valency, thus implicating Ld domains in modulation of integrin adhesio

113 Kinetic DNA cleavage and ATPase measurements implicate R79 in motor ring assembly on DNA, supporting

114 Environmental and hormonal factors are implicated in dysimmunity in multiple sclerosis.

115 ressed in cell types relevant to the traits, implicating these lncRNAs in multiple diseases.

116 do not involve the chloroplast ATP synthase, implicating this system in multiple photosynthetic proce

117 drial biogenesis and oxidative function, and implicate Perm1 in muscle adaptations that also occur in

118 Together these results implicate FAM46C in myeloma cell growth and survival and

119 In conclusion, our results implicate IL-8 in myeloma bone disease and point to the

120 aptation across the latitudinal gradient and implicate genes involved in nervous system function.

121 3 and the RE1 silencing transcription factor implicated respectively in neural plasticity and the spe

122 Thus, our work implicates BCL11A haploinsufficiency in neurodevelopment

123 It is among the most commonly implicated factors in neurodevelopmental autism spectrum

124 These observations may implicate sGCs in neuronal desensitization mechanisms fa

125 cd2 in a subset of NP neurons after axotomy, implicating their actions in neuronal cell death upon ne

126 Taken together, these results implicate GLRA2 in non-syndromic ASD, unveil a novel rol

127 These observations implicate macrophages in normal and aberrant cardiac con

128 These results implicate NR2A-NMDARs in normal working memory and sugge

129 These findings implicate new genes in NSC and demonstrate related patho

130 ry and remodeling properties of IL-32 in AT, implicating this cytokine in obesity-associated comorbid

131 Hence, these results implicate oxytocin in observational fear in mice (rather

132 Rings of TANGO1 surround COPII, implicating TANGO1 in organizing ER exit sites and in re

133 ramifications of the Hechtian oscillator may implicate AGPs in osmosensing or gravisensing and other

134 regulation in glioma endothelia, potentially implicating Cyp1b1 in other brain pathologies.

135 genotoxic stress and activates p53, further implicated CDK19 in p53 target gene expression.

136 he treatment of pain due to a wealth of data implicating its role in pain pathways.

137 a protein enriched in Lewy bodies and highly implicated in neurotoxicity in Parkinson's disease, is d

138 ni serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasi

139 This potentially implicates them in pathways such as de novo lipogenesis,

140 sion profiles and identity of the substrates implicate RHBDL2 in physiological or pathological proces

141 Our findings thus implicate PMN-MPs in PMN-mediated inflammation and epith

142 Our study now extends this by directly implicating it in POAG disease pathogenesis.

143 ritical steps of the metastatic cascade, and implicate these kinases in possible therapeutic interven

144 n (FISH), Northern blots, and RNA sequencing-implicates MRP RNA in pre-rRNA processing.

145 These results implicate LRRK2 in primary ciliogenesis and suggest that

146 crease in the absence of Clp1 activity, thus implicating Clp1 in promoter directionality.

147 Our data implicate Fosl2 in promoting the progenitor to cardiomyo

148 Together, these observations implicate PrimPol in promoting restart of DNA synthesis

149 d antitumoral responses, but recent evidence implicates them in promoting carcinogenesis in certain c

150 Although CD8 T cells have been implicated both in protection and in the cytokine-mediat

151 mmunogenic is one such feature that directly implicates this modification in protein synthesis.

152 Furthermore, we implicate Rnf145 in proteostasis of the Nox2 complex by

153 These findings implicate LCE proteins in psoriasis pathogenesis via a n

154 scriptome and genetic susceptibility further implicate NF-kappaB in psoriasis etiopathology.

155 Previous pharmacological studies have implicated this mechanism in PTP at hippocampal synapses

156 of breast cancer cells subjected to HFR and implicate Rac1 in radioresistance of breast cancer cells

157 ative receptor binding surface that directly implicates Skint-1 in receptor-ligand interactions cruci

158 PDE5A has been implicated previously in recognition-memory deficits and

159 These results implicate androgens in regulating distinct features of c

160 lly validate Cosmc as an IBD risk factor and implicate it in regulating the spatial pattern of dysbio

161 omology among sodium channels, our data also implicate MMP proteolysis in regulating the cell surface

162 Collectively, these results implicate NAc D2R in regulating both peripheral glucose

163 functional decay or "aging." Recent studies implicate protein deamidation in regulating signal trans

164 Our results implicate PTEF in regulating placental CSA binding of in

165 of non-miRNA dependent functions as well as implicating RNA in regulating DNMT1 activity and correct

166 only flavonoids, but also nucleotides, thus implicating TT8 in regulating pools of activated nucleot

167 These data further implicate alpha7 nAChRs in regulation of aggression, and

168 This is the first report to implicate mitophagy in regulation of tumour cells with h

169 Our earlier work implicated BetaM in regulation of gene expression throug

170 tly developed PTK6 kinase inhibitor, further implicating kinase activity in regulation of EMT and met

171 ption factor -2 ( SNAI2) (also called SLUG), implicating LGR4 in regulation of epithelial-mesenchymal

172 ciated with actively transcribed DDIT4 loci, implicating these bodies in regulation of basal DDIT4 ex

173 oss aversion in the depressed patients, also implicating impairment in regulatory processes.

174 Therefore, our study implicates REEP6 in retinal homeostasis and highlights a

175 sociation studies confirmed this finding and implicated this gene in schizophrenia.

176 In light of the clinical evidence implicating dopamine in schizophrenia and the prominent

177 Our data implicate CP110 in SDA assembly and ciliary vesicle dock

178 This could implicate these molecules in selective trafficking of me

179 ated with endometriosis risk (P<5 x 10(-8)), implicating genes involved in sex steroid hormone pathwa

180 rapidly activated during SI; several studies implicated its role in signaling to SI-induced programme

181 THEMIS during thymocyte positive selection, implicating THEMIS in signaling downstream of the T cell

182 Our findings implicate public TCR in skewing repertoire response duri

183 Despite strong biochemical evidence implicating NAIPs in specific detection of bacterial lig

184 Previous studies implicated PI3K signaling in SR-A-mediated activities an

185 Together, these findings strongly implicate BLA KORs in stress-induced nicotine seeking-li

186 These findings implicate MARKs early in synucleinopathy pathogenesis an

187 g cells, these neutrophils expressed markers implicating a role in T-cell exhaustion.

188 eracts with the T7SS secretion ATPase, EssC, implicating EsaE in targeting the EsaDG complex to the s

189 Together, these data implicate bb0318 in the oxidative stress response of B.

190 Together, our results implicate beta-arrestin in the modulation of Sstr3 cilia

191 ectrophysiological and neurochemical studies implicate cholinergic signaling in the basolateral amygd

192 Multiple lines of evidence implicate chromatin in the regulation of premessenger RN

193 Together, our findings implicate CNOT3 in the coordination of colonic epithelia

194 Collectively, our genome-wide analyses implicate condensin in the suppression of hundreds of lo

195 idence from preclinical and clinical studies implicate dopamine hypofunction in the pathophysiology o

196 f ILC2 expansion and cytokine production and implicate ETS1 in the regulation of Id2 at the inception

197 dy provides the first functional evidence to implicate GABA cells in the amygdala as regulators of ca

198 These data implicate gBcyt in the regulation of gB fusion function

199 ptome analysis in urothelial TEU-2 cells, we implicate it in the regulation of cell cycle, cytoskelet

200 Our studies implicate JMRV miRNAs in the suppression of innate antiv

201 The present findings implicate joint attention in the development of the chil

202 These findings implicate Kctd13 in the regulation of neuronal function

203 These data implicate LSD1 in the prevention of neurodegeneration vi

204 These data implicate monocyte CD36 in the mitigation of early infar

205 Together these data implicate Nfatc1 in the regulation of skin stem cell-ini

206 These data implicate PRMT5 in the regulation of adaptive memory Th

207 These findings implicate Rb1 in the regulation of the THO ribonucleopro

208 Together, the findings implicate retrosplenial cortex in the extraction of path

209 The data implicate SPARC in the noncell autonomous control of car

210 Our data implicate TET enzymes in the evolutionary dynamics of TE

211 These results implicate thalamostriatal projections in the pathophysio

212 Current models implicate the cerebellum in the prediction of the sensor

213 Genomic studies implicate this locus in the initiation of clinically sig

214 to the plasma membrane via the PH domain and implicate this mechanism in the inhibition of CME.

215 Together, these data implicate trkB signaling in the symptomatic efficacy and

216 and by using a zebrafish infection model, we implicate WarA in the ability of P. aeruginosa to evade

217 der (PTSD) showing attentional deficits have implicated abnormal activities in the frontal lobe.

218 functional MR imaging methods to investigate implicated abnormalities in the morphology and structura

219 More recent investigations have also implicated CARD14 in the pathogenesis of pustular psoria

220 n A (CypA), as well as CA mutant viruses, we implicated CypA in the SUN2-imposed block to HIV infecti

221 Genome-wide associated studies have implicated EZH2 in the control of height and mutations i

222 experimental and clinical observations have implicated gut microbiota in the pathogenesis of these d

223 lar interest, studies in fungal systems have implicated Hook proteins in the regulation of microtubul

224 NOD2 is implicated in changes in the composition of the intestin

225 immune cell population in the CNS, has been implicated in diseases in the brain and retina.

226 The collective frequency of KCNE2 variants implicated in LQT6 in the Exome Aggregation Consortium d

227 RBM4 also has been implicated in neurogenesis in the mouse embryonic brain.

228 dent chromatin remodeling proteins are being implicated increasingly in the regulation of complex beh

229 to methods described in a previous work that implicated Ivm in the arrangement and connectivity of co

230 While some studies have implicated Lewy bodies in the neocortex, others have poi

231 Additional cell-based studies implicated LRRK2 in the AP-3 complex-related intracellul

232 Prior studies have implicated miRNAs in the pathogenesis of motor neuron di

233 While several studies implicated Parkin in the regulation of mitophagy and pro

234 x30 (Asp-50, Asp-172, and Asp-179) have been implicated previously in the Ca(2+) sensitivity of other

235 ed in a variety of human tumors and has been implicated recently in the promotion of lung metastases.

236 er a century ago, the focal infection theory implicated these infections in the aetiology of several

237 of deletion or over-expression of PE_PGRS47 implicated this protein in the inhibition of autophagy i

238 Recent bioinformatics analysis data have implicated YY1 in the germinal center (GC) B-cell transc

239 vity predisposes individuals to diabetes and implicates abnormalities in the islet microenvironment i

240 These results uncover a novel mechanism that implicates Aurora A in the mitotic inactivation of trans

241 Increasing evidence implicates Ca(2+) in the control of cell migration.

242 Considerable evidence implicates cellular senescence in the biology of aging a

243 Recent evidence implicates exosomes in the aggregation of Abeta and spre

244 This study implicates microRNAs in the pathogenesis of AA.

245 e syndrome has remained elusive, recent work implicates mitochondrial dysfunction in the disease prog

246 nk between mTORC1 and ERalpha, which further implicates mTORC1 signaling in the pathogenesis of ER-po

247 Increasing evidence implicates serine proteinases in the proteolytic cascade

248 rus, an accumulating body of recent evidence implicates the virus in the etiology of serious patholog

249 The predominance of H-DNA implicates this structure in the instability associated

250 date in the general European population and implicates vitamin D in the etiology of multiple scleros

251 t this pretreatment decreased contractility, implicating activity in the TGF pathway in the establish

252 n addition, although we do not find evidence implicating altered proliferation in the rescue, we obse

253 The genetic evidence implicating amyloid-beta in the initial stage of Alzheim

254 these mutations is in the SSD binding site, implicating another subset in the putative CS binding si

255 tocellular carcinoma (HCC) development, thus implicating ATX/LPA in the causative link of cirrhosis a

256 deleting the fetal globin repressor BCL11A, implicating BCL11A in the function of the HBBP1 region.

257 ances including hippocampal memory deficits, implicating CD44 in the processes underlying hippocampal

258 mily) related to therapy resistance, further implicating cMET in the anticancer drug response.

259 ptor signaling abrogated induction of MCP-1, implicating it in the antitumor effects of IgE.

260 synthesis rates were less ligand-sensitive, implicating metabolic competence in the response heterog

261 iple myeloma cells against DEPTOR silencing, implicating mTORC1 in the critical role of DEPTOR in mul

262 a striking absence of primary neurogenesis, implicating n1-src in the specification of neurons early

263 (IKBKG) human gene manifest skeletal defects implicating NEMO in the regulation of bone homeostasis.

264 most likely to be incorrectly reported, thus implicating noise in the probe feature dimension as a so

265 in heart rate in denervated ex vivo hearts, implicating parasympathetic hyperexcitability in the Scn

266 ochondrial antiviral signaling protein MAVS, implicating PB2 in the regulation of innate immune respo

267 e requirement for asymmetric DNA substrates, implicating RAG2 in the origins of the "12/23 rule," a f

268 orrelate with mRNA steady state levels, thus implicating RTL2 in the regulation of protein-coding gen

269 a subsequent memory retrieval task, strongly implicating sex steroids in the regulation of this circu

270 gradation, reduces neuroblast proliferation, implicating SKP2 in the maintained proliferation of MYCN

271 as well as hyperplasia of the intimal layer, implicating T cells in the maladaptive behavior of vesse

272 tween ANS tasks and mathematics performance, implicating the ANS in the development of numerical skil

273 o light in the context of the JC hypothesis, implicating them directly in the processes that have eme

274 nt ETV4- and AP1-MED25 interactions, thereby implicating these factors in the recruitment of MED25 to

275 de changes in the cholinergic pathway genes, implicating this miR in the avoidance of seizures.

276 n from DSB-clusters utilizes Parp1 activity, implicating alt-EJ in their formation.

277 and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes b

278 Among the implicated genes in these disorders are those encoding p

279 Neuroimaging studies in humans have implicated insular cortex in these phenomena.

280 t exacerbated L-ala,SP + amiodarone effects, implicating the prodrugs in these effects.

281 edifferentiation of carcinomatous ccRCCs and implicate specific genes in this process.

282 Although SYK has not been implicated previously in this disease, we found that its

283 ession of the cytoskeletal protein vimentin, implicating hypothalamic remodelling in this response.

284 Positional analysis of lincRNA loci implicated involvement in transcriptional regulation.

285 were enriched for Prmt1 downstream targets, implicating Prmt1 in translation control.

286 as associated with greater symptom severity, implicating a role in trauma-related psychopathology in

287 eg lineage resulted in immune hyperactivity, implicating Notch activity in Treg homeostasis.

288 Together, these results implicate Notch signaling in tumor recurrence from dorma

289 on proteoglycans, an activity that has been implicated strongly in tumor metastasis and angiogenesis

290 in cancer genomes, but experimental evidence implicating condensin dysfunction in tumorigenesis is la

291 We also present findings that implicate leptin signaling in uridine homeostasis and co

292 Nonspecific measures of brain activity have implicated the striatum in value-based attention.

293 ition shunts the kynurenine pathway-which is implicated as dysfunctional in various psychiatric disor

294 Drug studies in animal models have implicated pannexin1 (Panx1) in various types of pain, i

295 s an attractive technique to test hypotheses implicating telomere length in various cardiac pathologi

296 itional Map3k3 knockout mice have previously implicated MAP3K3 in vascular development.

297 These data suggest that in vitro studies implicating APOBEC3 proteins in virus resistance may not

298 p2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation.

299 Functional analysis showed that an implicated variant in WNT4 alters the binding of the est

300 Our observations implicate disruption in ZnT2 function as a modifier of s