ライフサイエンスコーパス: implication

1 hat could have tremendous healthcare savings implications.

2 g anatomy, but also has important behavioral implications.

3 function (LoF) of human genes have clinical implications.

4 as a function of muscle length has important implications.

5 genic resistance, with potential therapeutic implications.

6 l cancer (CRC), with clinical and biological implications.

7 igh- or low-affinity binding with functional implications.

8 enotypes with both theoretical and practical implications.

9 n, which could have important enteric health implications.

10 ions, and these findings may have biological implications.

11 ddressed, demonstrating their 'system-level' implications.

12 t, which has important economic and resource implications.

13 olic imbalance has significant public health implications.

14 have potential short- and long-term clinical implications.

15 RV144 vaccine trial have important societal implications.

16 ng across this axis has important functional implications.

17 r these observations and their public health implications, and explore clinical and population health

18 g with important fundamental surface science implications, and it could be extended to other systems.

19 These studies have important translational implications as both EpCAM and ERK are currently being t

20 distinction may have substantial therapeutic implications as direct anti-inflammatory interventions f

21 Criegee intermediates have implications as key intermediates in atmospheric, organi

22 Our finding could have therapeutic implications as side effects of Flunarizine are low and

23 This finding has important clinical implications because of the risk of additional tumors an

24 These results have important clinical implications, because topical therapies that target IFN-

25 ture area of future investigation, as it has implications beyond antipsychotic prescribing.

26 ed ejection fraction (HFpEF), its functional implications beyond the reflection of left ventricular (

27 udies, it may have considerable programmatic implications (e.g., the necessity to screen for iron sta

28 e temporal tuning of neural activity and its implication for neural codes.

29 essive form of breast cancer, with potential implications for a novel immunotherapeutic approach.

30 for Ca(2+) mobilization by beta2AR has broad implications for adrenergic signaling, cross-talk with o

31 Our discovery here presented has implications for all genetic aspects of diamond growth,

32 106 as an RNA binding protein with important implications for ALS.

33 Our findings have important implications for antibiotic stewardship and public healt

34 Our findings have important implications for antibiotic stewardship and should be co

35 oad for APP and these secretases, with major implications for APP processing and amyloidogenesis.

36 ocean oxygen concentrations can have direct implications for atmospheric carbon sequestration.

37 ancing selectivity for viral RNA, with major implications for autoimmune disease and cancer.

38 nectin/nectin receptor interactions and have implications for better understanding the molecular basi

39 ic complexity and evolvability that may have implications for biological evolution.

40 unusual envelope found in AFV1 also has many implications for biotechnology, since this membrane can

41 e, confirmed in patients, may have important implications for biotherapies such as vaccines and monoc

42 tore quiescence of myeloid-biased HSCs, with implications for blood disorders, aging, and immunity.

43 atric between breeding seasons has important implications for both ecology and evolution, including t

44 h as fire can influence soil C dynamics with implications for both the parameterization of earth syst

45 al strategy for trans-repression, with clear implications for breast cancer and other diseases.

46 Our study has important implications for cancer immunotherapy as we define key t

47 actionable genetic changes with established implications for cancer screening or prevention.

48 al and national scale, and have constructive implications for carbon assessment, modelling, and manag

49 is review discusses these advances and their implications for clinical management of the ACS for the

50 munity composition, and may have significant implications for CO2 losses from tropical forest soils u

51 l fluxes at and near the ocean margins, with implications for coastal organisms and ecosystems.

52 riptome organization and riboregulation with implications for colonization of the human nasopharynx.

53 goal in evolutionary biology, with important implications for conservation, medicine, and agriculture

54 ediating homolog spatial juxtaposition, with implications for crossover (CO) patterning/interference.

55 and re-rankings, which can have significant implications for decision making.

56 ate of stable cell cycle exit with important implications for development and disease.

57 mechanistic insights from animal models, and implications for development of novel therapies targetin

58 d related emergent functionalities that have implications for device applications.

59 als, and more broadly fungal metabolism, has implications for diverse research disciplines ranging fr

60 o and out of Earth's surface environment has implications for Earth's climate and habitability.

61 EBNA3A in the suppression of apoptosis with implications for EBV lymphomagenesis.

62 The findings have implications for education, economics, and public policy

63 viral-specific CD8(+) T cells, a result with implications for elimination of latent HIV-1 infection b

64 g over the past 40 years not only have major implications for energy and water balance, but also have

65 patiotemporal variations of MEFs and explore implications for energy storage technologies.

66 These observations have implications for environmental fate and toxicity of AgNP

67 generating the acinar lineage that has broad implications for epithelial morphogenesis.

68 ty drive the evolution of the DFE, with many implications for evolutionary and medical genomics.

69 ctional regions within genomes has important implications for evolutionary potential.

70 'phenotype specificity' occurs has important implications for exercise prescription.

71 DN B cell activation and differentiation has implications for extrafollicular plasmablast development

72 These results have implications for foraging theory and stability of grazin

73 ffects larger trees in tropical forests, but implications for forest composition and carbon (C) cycli

74 sadvantage on frontal lobe development (with implications for functioning) during adolescence.

75 Our findings have important implications for fundamental understanding of RVFV virul

76 rate these principles and speculate on their implications for further study.

77 ght into the pathogenetic basis of L-ORD has implications for future therapeutic strategies such as g

78 The results may have implications for future therapeutic trials involving ant

79 context for alt-EJ repair and have important implications for genome editing and genome evolution.

80 , the degradation of the ice core could have implications for glacial lake outburst risk.

81 onse to warm climates in Antarctica and have implications for glacial response to Holocene warming.

82 nges in these sources could have significant implications for global warming.

83 infancy and risk of childhood obesity, with implications for health-care delivery and obesity preven

84 This has important implications for healthcare policies, suggesting that in

85 of this conformational rearrangement and its implications for heme transfer via site-directed mutagen

86 Differences in survival could have important implications for hospital staffing, training, and resour

87 Our study has broad implications for human disorders associated with UBE3A g

88 stasis of primary cilia, which has important implications for human disorders related to primary cili

89 cts of scopolamine could have great clinical implications for humans; however, rats and mice administ

90 chanisms associated with brain disorders and implications for identifying new treatments.

91 Preliminary evidence suggests potential implications for immune and infectious-disease-related o

92 types without user training, which has broad implications for improved assay development in high-cont

93 cal and alternative signaling pathways, with implications for improved understanding of disease recur

94 underlying photoprotective dissipation, with implications for increasing biomass yields and developin

95 These findings have important implications for infectious HTLV-1 spread, particularly

96 tive Mycobacterium tuberculosis with unknown implications for infectiousness.

97 ellular function and inflammation with broad implications for inflammation-associated diseases and th

98 CAT1 in macrophage function with therapeutic implications for inflammatory conditions.

99 The model has important implications for interventions that target signaling pat

100 ty Pathway Analysis of these targets reveals implications for intracellular pathways and biological p

101 These results have significant implications for intranasal vaccines, which deliver anti

102 equence of an incomplete islet BM, which has implications for islet survival and transplanted graft l

103 , with different logistical requirements and implications for long-term graft patency.

104 forage conditions than smaller animals with implications for maintenance of migration and body size

105 cally affected by early malnutrition and the implications for males and females respectively.

106 These observations have implications for mechanisms of neuronal death under cond

107 This has significant health implications for medical device development in the futur

108 n, with potential prognostic and therapeutic implications for metastasis by cancers that preferential

109 to the rise of ecological interactions, with implications for microbiome research and synthetic ecolo

110 n and spread of OHRB, and describe potential implications for natural halogen and carbon cycles.

111 ing of these layers of control has important implications for organismal health and could offer new t

112 welling are universal, our findings may have implications for other biofilm-forming bacterial species

113 on of N-methoxybenzamides and have important implications for other Pd-catalyzed aerobic C-H oxidatio

114 fault mode network, which may have important implications for our current understanding of healthy an

115 panded, low density protein states has broad implications for our understanding of allostery and sugg

116 egoistically biased altruism, with important implications for our understanding of economic and socia

117 These findings may have implications for our understanding of how altered folate

118 A refines neoantigen prediction and may have implications for our understanding of resistance mechani

119 This has significant global implications for our understanding of soil N cycling pat

120 These results have important implications for our view of modern chondrichthyan origi

121 ced, under what circumstances, and with what implications for participants.

122 This educational gap can have significant implications for patients' safety.

123 ly diverse human populations, with immediate implications for personalized medicine.

124 ng from a changing climate can have profound implications for plant interactions in desert communitie

125 These findings have important implications for predicting the stability and mobility o

126 represent a simplification without negative implications for prognostic, diagnostic, and therapeutic

127 Finally, we consider the implications for rational drug development, in particula

128 inct conformational changes in G and discuss implications for receptor-activated virus entry.

129 xpression and transcriptional bursting, with implications for regulation of pluripotency and developm

130 ession of respiratory proteins, with unknown implications for respiratory activity.

131 isk factors or protective factors has direct implications for risk prediction models and the interpre

132 hrough integrative clustering have important implications for stratification of future clinical trial

133 This finding has significant implications for systemwide capacity management and shou

134 genetic variation with potential therapeutic implications for T2D, we analyzed and replicated genome-

135 reveal hotspots for sequence evolution with implications for targeting and secondary structure.

136 limate change on soil systems, with profound implications for terrestrial ecosystem functioning.

137 Our study has implications for the antigenic stimulus required for ant

138 This has implications for the assembly kinetics, morphology, and

139 s core-mantle boundary region have important implications for the chemical composition and thermal st

140 These findings have implications for the choice of device therapy in patient

141 These findings also have implications for the combined use of CoRAs and FIs in an

142 control of stomatal aperture with important implications for the control of plant photosynthesis, wa

143 This theory has profound implications for the design and ethics of public policie

144 It also has important implications for the design of lifespan experiments as a

145 Our findings have important implications for the design of maternal vaccination stra

146 escribed herein are expected to have general implications for the design of selective transformations

147 oise in metazoan signaling networks and have implications for the development of drugs that target th

148 ion of labelled protein, which has important implications for the development of future PALM tags.

149 erent types of reactive states has important implications for the development of new therapies for CN

150 These insights have implications for the development of novel modulators of

151 These findings have implications for the development of selective allosteric

152 mune system, and metabolism, and discuss the implications for the development of stromal compartment-

153 ssification of lymphoma and have significant implications for the diagnosis and clinical management o

154 MIR features have implications for the formation of simple and complex rea

155 s how these differences might have important implications for the functional consequences of noncodin

156 The reasons for this trend and the implications for the future trajectory of TB in the US r

157 nem resistance in Escherichia coli has major implications for the management of common infections.

158 This has important implications for the management of these patients.

159 Our results have important implications for the marine-terrestrial biodiversity gra

160 assic GPCR ternary-complex model, with broad implications for the multiplicity inherent in signaling

161 These results have implications for the next-generation design of receptors

162 These results have implications for the pancancer use of targeted drugs and

163 These findings have important implications for the pathogenesis of TNF-mediated entero

164 Overall, our findings have implications for the planning of therapeutic and diagnos

165 The genome conservation observed also has implications for the potential success of a therapeutic

166 Our findings have therapeutic implications for the prevention and treatment of food al

167 ocean-atmosphere system, likely had profound implications for the rate and magnitude of the end-Trias

168 This reactivity has important implications for the recently developed dual Ni/photored

169 We further discuss the implications for the rest of the gasdermin (GSDM) family

170 iple of nutrient-dependent fitness costs has implications for the stability of cooperation in pathoge

171 y in the disease process, and have important implications for the stage of disease where trials of an

172 he same patient has critical and encouraging implications for the success of future targeted therapie

173 duction velocity, which potentially has wide implications for the temporal transfer of information in

174 urrent treatment criteria may have potential implications for the timing of antiviral therapy to achi

175 g of p53 regulation and may have significant implications for the treatment of cancer and other disea

176 Our findings have important implications for the understanding of compartmentalized

177 Our findings have important implications for the use of Adelie penguins in Southern

178 Implications for the use of CP 3 in electronic devices a

179 lives of these apes, with potentially major implications for their broader evolutionary biology.

180 in a context-free manner and have important implications for theories of reinforcement learning and

181 report evidence challenging this view, with implications for therapeutically targeting Mdm2.

182 ace in living animals, and we comment on its implications for timescales of host-microbe interactions

183 f Gata2 influence fate establishment and has implications for transcription factor-related hematologi

184 ploying life cycle-specific sterols and have implications for treatment.

185 e relevant than previously thought, and have implications for tree population responses to future env

186 We discuss potential implications for trial design based on this framework.

187 brain shrinkage and regrowth, with important implications for understanding adaptations to changing e

188 These new findings have important implications for understanding D-serine-mediated N-methy

189 This presents implications for understanding dopamine processing of mo

190 gulating EGFR neddylation has broad-reaching implications for understanding how homeostasis is achiev

191 e, I review these accounts and discuss their implications for understanding how predictions of the se

192 e theory of numerical development along with implications for understanding mathematics disabilities.

193 These findings have implications for understanding mineral controls on As cy

194 ogy, immunology, and pathogenesis, and their implications for understanding natural infection and cur

195 These findings have implications for understanding the causes and consequenc

196 dological and empirical insights, with broad implications for understanding the functional and cultur

197 e defence is species specific, and they have implications for understanding the pattern of Bd populat

198 or nonfunctional forms of Env has important implications for understanding the role of neutralizing

199 te roles of additional H3.3 residues and has implications for use in other developmental systems.

200 imized by manipulating Ag presentation, with implications for vaccine design.

201 iform shape at high purities has significant implications for various applications in biological rese

202 Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis

203 CO2 concentrations rise, having global-scale implications for water balance, carbon storage, and rela

204 ung cancer, offering findings with immediate implications, given the existing clinical availability o

205 owing HMPV entry and have important clinical implications.IMPORTANCE Human metapneumovirus (HMPV) is

206 n of microorganisms infecting mammals, their implication in plant virus recognition and immunogenicit

207 nsiderable attention because of its possible implication in several neurological and psychiatric diso

208 ly pathogenic for mammals and their possible implication in the development of diseases associated wi

209 1-FBXW7 interactions have potential clinical implications in breast and ovarian cancer treatment.

210 nsitions using alloying is a novel idea with implications in designing all 2D device architecture as

211 stic nodules may have relevant translational implications in early diagnosis.

212 This methodology has potential implications in identifying protein regions for drug tar

213 These findings might have important implications in the clinical setting for the development

214 xpected findings and discuss the mechanistic implications in the design and application of Rho GTPase

215 BRCAness has important implications in the management and treatment of patients

216 Our findings may have significant implications in the treatment of RA patients with anti-T

217 ape setting and have potential conservation implications in this critically endangered species.

218 hotobiological effects, which have important implications in understanding its impact on skin homeost

219 s lack of a definitive conclusion might have implications in understanding the pathogenesis of both c

220 f human CSF flux and open important clinical implications, including concepts for drug delivery and n

221 sisting inequalities and their public health implications, new and effective policies to reduce inequ

222 transporting effects between populations has implications not only for ABMs but for all epidemiologic

223 The implication of dopamine was assessed by comparing perfor

224 findings provide the first evidence for the implication of lnc-KDM5D-4 in key processes related to f

225 We discuss the implication of our finding for the gradient of life-hist

226 A key implication of our work is that important nonequilibrium

227 An unexplored implication of sulfate enrichment is alteration of the c

228 An important implication of these results is that ribbon-associated v

229 One possible implication of this is that disruption of olivocerebella

230 An important implication of this multireference character is the dram

231 ntal concerns with the long-term storage and implications of a leak from a carbon capture storage (CC

232 gnosing diastolic dysfunction; 3) prognostic implications of abnormalities in E/A and E/e'; 4) specia

233 mphasizing the need to better understand the implications of ALAN for migratory bird populations.

234 et global collaboration to review the health implications of breastfeeding was among the first to con

235 iscuss potential biological and evolutionary implications of CDI system-mediated interbacterial compe

236 rstanding of the ecological and evolutionary implications of cooperation in social species.

237 Understanding the implications of distinct cell death pathways will help i

238 We then evaluate the implications of general intelligence in nonhuman animals

239 The conservation implications of generally low connectivity are that the

240 Finally, we discuss the implications of GPCR conformational plasticity for drug

241 Implications of GSK3 activity for axon regeneration are

242 el's assessment of the research and practice implications of his conclusions has remarkable contempor

243 Further work is needed to determine the implications of increased thalamic connectivity with sen

244 ermine the proportion and potential clinical implications of inherited variants detected using simult

245 anizations, stakeholders must understand the implications of misaligned top-down cost management appr

246 The environmental implications of MoS2 nanosheets are emphasized, and rese

247 oparticles is of increasing concern, and the implications of nanomaterial exposure on the human immun

248 Future studies are required to specify the implications of our dataset and further reveal the compl

249 Important implications of our findings for engineering synthetic c

250 studies are needed to evaluate the clinical implications of our findings.

251 We also discuss the implications of our results for the design of therapies

252 To examine the clinical implications of positive or negative direct immunofluore

253 prevalence, pathophysiology, and management implications of pulmonary hypertension in patients with

254 I then discuss the implications of reassortment for influenza A virus evolu

255 This study seeks to estimate the carbon implications of recent changes in China's economic devel

256 to determine the prevalence of hypertension, implications of recommendations for antihypertensive med

257 The prevalence, determinants, and implications of relative bradycardia (heart rate, < 80 b

258 s are required for elucidation of functional implications of such noncanonical translation initiation

259 review the known ecological and evolutionary implications of symbiont gains, switches, and replacemen

260 Our findings also elucidate the functional implications of the decades-old observation of mitotic l

261 Implications of the findings are discussed.

262 ZEB1, OVOL2, p63 and p300) and translational implications of the Grainyhead proteins in cancer are di

263 The implications of these findings and the potential of elec

264 We discuss the implications of these findings for mitigation strategies

265 The implications of these findings in terms of emotional res

266 We also discuss the physiological implications of these findings on the basal activity of

267 The therapeutic implications of these natural, remote-loaded nanoformula

268 We will also discuss the translational implications of these new developments.

269 The potential epidemiological implications of these results are discussed.

270 h a perspective on the prospects and broader implications of this field.

271 20-opsonized CLL B cells, and we discuss the implications of this finding in patients with CLL treate

272 The implications of this functional diversity for the regula

273 The implications of this fundamental study extend to a broad

274 principles, recent discoveries, and clinical implications of this promising field of research.

275 To understand the functional implications of this rapid evolution, we focused on a hi

276 We investigated the implications of this relationship for the Los Angeles ar

277 tion of the recovered phases and discuss the implications of this shock synthesis for the stability o

278 with detailed eruption data and examine the implications of this variation for clinical care.

279 tein predominates in solution and we discuss implications of this with regards to the RECQL5 mechanis

280 The implications of using different chemotherapeutic regimen

281 controls and investigated long-term clinical implications of vitamin B-6 deficiency in stable outpati

282 defects, this gene-gene interaction may have implications on craniofacial disorders.

283 sing, especially thermal treatment, may have implications on mycotoxins in products available for con

284 ctorial hypothesis that has potential direct implications on the epidemiology and management of chlam

285 ing interface with m4E-BPs, with significant implications on the understanding of translation regulat

286 -specific manner has significant mechanistic implications regarding sex biases in NDDs.

287 t self-imposed deprivation, which carries no implications regarding the ability to realize deferred r

288 anti-angiogenic effects, providing important implications regarding the design of novel miRNA-based t

289 These mechanisms have clinical implications that relate to the increasing use of anti-I

290 limitations of this form of analysis and the implications that this may have for bioinformatics datab

291 Our results have two important implications, the need for caution in the interpretation

292 Despite their large-scale implications, these interactions remain unquantified at

293 -mediated T-cell suppression in tumors, with implications to broadly improve the efficacy of cancer t

294 to new cytokine combinations and doses, with implications to fine-tuned immunotherapies.

295 ma membrane-associated Ras GTPases has major implications to the regulation of cell signaling.

296 lammation, these findings may have important implications to understanding the behaviour of these cel

297 or TNBC cell invasiveness, thereby providing implications toward developing an effective therapy for

298 The clinical implication was studied in blood samples of patients wit

299 These findings have implications with regard to the pathogenesis of this eni

300 First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium chan