ライフサイエンスコーパス: implication for

1 The results discussed herein bear important implications for a more comprehensive and reliable envir

2 essive form of breast cancer, with potential implications for a novel immunotherapeutic approach.

3 ncidental nature of this association and the implications for AAV vector safety.

4 in China annually from 1996 to 2015 to draw implications for achievement of the SDGs for China and o

5 l to alter important genetic parameters with implications for adaptation and ecosystem vulnerability

6 for Ca(2+) mobilization by beta2AR has broad implications for adrenergic signaling, cross-talk with o

7 This has important implications for air-sea interaction and implies that oc

8 -vascularization phenotype, which could have implications for alcohol-induced tumor angiogenesis.

9 Our discovery here presented has implications for all genetic aspects of diamond growth,

10 106 as an RNA binding protein with important implications for ALS.

11 ty under eculizumab treatment with important implications for anti-C5 therapy in general.

12 Our findings have important implications for antibiotic stewardship and public healt

13 Our findings have important implications for antibiotic stewardship and should be co

14 oad for APP and these secretases, with major implications for APP processing and amyloidogenesis.

15 ocean oxygen concentrations can have direct implications for atmospheric carbon sequestration.

16 ancing selectivity for viral RNA, with major implications for autoimmune disease and cancer.

17 nectin/nectin receptor interactions and have implications for better understanding the molecular basi

18 ic complexity and evolvability that may have implications for biological evolution.

19 unusual envelope found in AFV1 also has many implications for biotechnology, since this membrane can

20 e, confirmed in patients, may have important implications for biotherapies such as vaccines and monoc

21 tore quiescence of myeloid-biased HSCs, with implications for blood disorders, aging, and immunity.

22 atric between breeding seasons has important implications for both ecology and evolution, including t

23 This work has significant implications for both fundamental understanding and risk

24 wnstream transcriptional response, which has implications for both normal cell function as well as di

25 Therefore, the results have implications for both species and may also add to our un

26 h as fire can influence soil C dynamics with implications for both the parameterization of earth syst

27 al strategy for trans-repression, with clear implications for breast cancer and other diseases.

28 Our study has important implications for cancer immunotherapy as we define key t

29 d its target gene expression, with potential implications for cancer prognosis and therapy.

30 actionable genetic changes with established implications for cancer screening or prevention.

31 al and national scale, and have constructive implications for carbon assessment, modelling, and manag

32 Our results thus have implications for cellular TFIID assembly and suggest a n

33 is review discusses these advances and their implications for clinical management of the ACS for the

34 munity composition, and may have significant implications for CO2 losses from tropical forest soils u

35 l fluxes at and near the ocean margins, with implications for coastal organisms and ecosystems.

36 riptome organization and riboregulation with implications for colonization of the human nasopharynx.

37 goal in evolutionary biology, with important implications for conservation, medicine, and agriculture

38 ediating homolog spatial juxtaposition, with implications for crossover (CO) patterning/interference.

39 of neonatal tongue protrusion has important implications for current understanding of primate imitat

40 and re-rankings, which can have significant implications for decision making.

41 ate of stable cell cycle exit with important implications for development and disease.

42 mechanistic insights from animal models, and implications for development of novel therapies targetin

43 ell envelope structure and dynamics and have implications for development of TB drug cocktails.

44 d related emergent functionalities that have implications for device applications.

45 aumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy.

46 ses in wildlife populations with concomitant implications for disease control in wildlife of conserva

47 pidemiological and ecological questions with implications for disease management.

48 t CpG markers may potentially have practical implications for disease prevention and treatment.

49 als, and more broadly fungal metabolism, has implications for diverse research disciplines ranging fr

50 Implications for DNA-based species identification assays

51 o and out of Earth's surface environment has implications for Earth's climate and habitability.

52 ight reflected back to space, with important implications for Earth's climate.

53 EBNA3A in the suppression of apoptosis with implications for EBV lymphomagenesis.

54 The findings have implications for education, economics, and public policy

55 viral-specific CD8(+) T cells, a result with implications for elimination of latent HIV-1 infection b

56 g over the past 40 years not only have major implications for energy and water balance, but also have

57 patiotemporal variations of MEFs and explore implications for energy storage technologies.

58 These observations have implications for environmental fate and toxicity of AgNP

59 generating the acinar lineage that has broad implications for epithelial morphogenesis.

60 text] possible vectors and has a variety of implications for erasure coding, compressed sensing, and

61 with some lab-based findings, with important implications for estimated health and air quality impact

62 on than previously thought, with interesting implications for eukaryotic genome evolution.

63 Collectively, these findings have broad implications for evolution and for our understanding of

64 ty drive the evolution of the DFE, with many implications for evolutionary and medical genomics.

65 ctional regions within genomes has important implications for evolutionary potential.

66 varying cognitive demand and have important implications for examining brain-behavior associations i

67 'phenotype specificity' occurs has important implications for exercise prescription.

68 DN B cell activation and differentiation has implications for extrafollicular plasmablast development

69 These findings have considerable implications for families of older people who provide th

70 These results have implications for foraging theory and stability of grazin

71 ffects larger trees in tropical forests, but implications for forest composition and carbon (C) cycli

72 sadvantage on frontal lobe development (with implications for functioning) during adolescence.

73 Our findings have important implications for fundamental understanding of RVFV virul

74 rate these principles and speculate on their implications for further study.

75 Our data may have implications for future research focusing on optimal pat

76 These conclusions have implications for future satellite lidar Cal/Val efforts,

77 ght into the pathogenetic basis of L-ORD has implications for future therapeutic strategies such as g

78 The results may have implications for future therapeutic trials involving ant

79 These results might have implications for future therapeutic trials targeting tau

80 ese results may have important public policy implications for genetic counseling of SCT carriers.

81 context for alt-EJ repair and have important implications for genome editing and genome evolution.

82 , the degradation of the ice core could have implications for glacial lake outburst risk.

83 onse to warm climates in Antarctica and have implications for glacial response to Holocene warming.

84 nges in these sources could have significant implications for global warming.

85 infancy and risk of childhood obesity, with implications for health-care delivery and obesity preven

86 This has important implications for healthcare policies, suggesting that in

87 of this conformational rearrangement and its implications for heme transfer via site-directed mutagen

88 Differences in survival could have important implications for hospital staffing, training, and resour

89 Their results have broad implications for how prefrontal networks integrate the t

90 Our study has broad implications for human disorders associated with UBE3A g

91 stasis of primary cilia, which has important implications for human disorders related to primary cili

92 cts of scopolamine could have great clinical implications for humans; however, rats and mice administ

93 chanisms associated with brain disorders and implications for identifying new treatments.

94 Preliminary evidence suggests potential implications for immune and infectious-disease-related o

95 types without user training, which has broad implications for improved assay development in high-cont

96 cal and alternative signaling pathways, with implications for improved understanding of disease recur

97 Implications for improving the cortical rTMS target for

98 underlying photoprotective dissipation, with implications for increasing biomass yields and developin

99 There are widespread implications for increasing the scope of human genetic v

100 These findings have important implications for infectious HTLV-1 spread, particularly

101 tive Mycobacterium tuberculosis with unknown implications for infectiousness.

102 These conclusions have far-reaching implications for inferences in leaf hydraulics, gas exch

103 ellular function and inflammation with broad implications for inflammation-associated diseases and th

104 CAT1 in macrophage function with therapeutic implications for inflammatory conditions.

105 This result has implications for interpreting disease phenotypes in anim

106 ng the last deglaciation, both of which have implications for interpreting geodetic measurements of l

107 This has implications for interpreting prehistoric migration dyna

108 The model has important implications for interventions that target signaling pat

109 ty Pathway Analysis of these targets reveals implications for intracellular pathways and biological p

110 These results have significant implications for intranasal vaccines, which deliver anti

111 These findings have implications for iP-targeted therapeutic development.

112 equence of an incomplete islet BM, which has implications for islet survival and transplanted graft l

113 icides from a few days to weeks, with strong implications for long-range transport and potential heal

114 , with different logistical requirements and implications for long-term graft patency.

115 forage conditions than smaller animals with implications for maintenance of migration and body size

116 cally affected by early malnutrition and the implications for males and females respectively.

117 These findings may have important implications for manipulating Tregs to control inflammat

118 s, but also enhances inflammation, which has implications for many inflammatory cutaneous diseases.

119 so regulates functions outside the DDR, with implications for many other frontiers of research.

120 the emergence of resistance, with potential implications for mechanism-based strategies to improve v

121 These observations have implications for mechanisms of neuronal death under cond

122 This has significant health implications for medical device development in the futur

123 n, with potential prognostic and therapeutic implications for metastasis by cancers that preferential

124 to the rise of ecological interactions, with implications for microbiome research and synthetic ecolo

125 nable immune attack on tumors, with clinical implications for molecular markers to modify emerging tr

126 n and spread of OHRB, and describe potential implications for natural halogen and carbon cycles.

127 e temporal tuning of neural activity and its implication for neural codes.

128 elerated soil erosion, which has substantial implications for nutrient and carbon cycling, land produ

129 ion with potentially important public health implications for obesity control.

130 future abrupt SPG cooling, entailing crucial implications for observation and adaptation policy.

131 ing of these layers of control has important implications for organismal health and could offer new t

132 welling are universal, our findings may have implications for other biofilm-forming bacterial species

133 These findings may also have implications for other diseases involving the accumulati

134 on of N-methoxybenzamides and have important implications for other Pd-catalyzed aerobic C-H oxidatio

135 fault mode network, which may have important implications for our current understanding of healthy an

136 hology, innate immune training has important implications for our understanding and treatment of neur

137 panded, low density protein states has broad implications for our understanding of allostery and sugg

138 egoistically biased altruism, with important implications for our understanding of economic and socia

139 These findings may have implications for our understanding of how altered folate

140 ofilm fluid-like behavior may have important implications for our understanding of how fluid flow inf

141 The findings may have implications for our understanding of neural circuits th

142 A refines neoantigen prediction and may have implications for our understanding of resistance mechani

143 This has significant global implications for our understanding of soil N cycling pat

144 These results have important implications for our view of modern chondrichthyan origi

145 t short-term protection, which has important implications for outbreak management.

146 ced, under what circumstances, and with what implications for participants.

147 ntrol T-cell cross-reactivity with important implications for pathogen surveillance, autoimmunity, an

148 These observations have immediate clinical implications for patients with ERBB2/HER2-negative breas

149 This educational gap can have significant implications for patients' safety.

150 exhibits unique features that have important implications for Pd-catalyzed aerobic oxidation catalysi

151 ly diverse human populations, with immediate implications for personalized medicine.

152 provide previously unidentified therapeutic implications for PKCzeta inhibitors in diminishment of b

153 ng from a changing climate can have profound implications for plant interactions in desert communitie

154 These results have important implications for potential roles of polysaccharides in t

155 These findings have important implications for predicting the stability and mobility o

156 fully transmitted HIV variants has important implications for preventative interventions.

157 prostate cancer progression, with potential implications for prognosis and therapeutic intervention.

158 represent a simplification without negative implications for prognostic, diagnostic, and therapeutic

159 espond to pathogenic ncRNAs, which has broad implications for providing new opportunities for underst

160 lume thyroid surgeon is important, as it has implications for quality improvement, criteria for refer

161 We discuss implications for race-adapted cancer screening programs

162 Finally, we consider the implications for rational drug development, in particula

163 inct conformational changes in G and discuss implications for receptor-activated virus entry.

164 xpression and transcriptional bursting, with implications for regulation of pluripotency and developm

165 ession of respiratory proteins, with unknown implications for respiratory activity.

166 naling and immune regulation in melanoma and implications for responses to treatment, organized in th

167 isk factors or protective factors has direct implications for risk prediction models and the interpre

168 ependent granulomatous disease with clinical implications for sarcoidosis.

169 activity impact cancer risk, with potential implications for species ecology.

170 hrough integrative clustering have important implications for stratification of future clinical trial

171 This shift is thought to have important implications for stress-related psychopathologies, inclu

172 roteins and protein complexes with potential implications for structural biology, proteomics, biomark

173 This finding has significant implications for systemwide capacity management and shou

174 genetic variation with potential therapeutic implications for T2D, we analyzed and replicated genome-

175 These findings have important implications for targeted vector control and active surv

176 reveal hotspots for sequence evolution with implications for targeting and secondary structure.

177 a high enough concentration of risk to have implications for targeting preventive interventions.

178 limate change on soil systems, with profound implications for terrestrial ecosystem functioning.

179 Our study has implications for the antigenic stimulus required for ant

180 This has implications for the assembly kinetics, morphology, and

181 s core-mantle boundary region have important implications for the chemical composition and thermal st

182 These findings have implications for the choice of device therapy in patient

183 These findings also have implications for the combined use of CoRAs and FIs in an

184 This has major implications for the conservation and management of the

185 control of stomatal aperture with important implications for the control of plant photosynthesis, wa

186 This finding may have important implications for the control of premature cervical ripen

187 This theory has profound implications for the design and ethics of public policie

188 Our findings have significant implications for the design of future vaccines that targ

189 It also has important implications for the design of lifespan experiments as a

190 Our findings have important implications for the design of maternal vaccination stra

191 iofilm-phage interactions have broad-ranging implications for the design of phage applications in bio

192 These observations will have implications for the design of reductive processes invol

193 escribed herein are expected to have general implications for the design of selective transformations

194 Our work has important implications for the development of appropriate training

195 These findings have significant implications for the development of bTB management strat

196 oise in metazoan signaling networks and have implications for the development of drugs that target th

197 vert and evade host immunity and discuss the implications for the development of EBV+ PTLD.

198 g in other anxiety disorders, with potential implications for the development of exposure-based thera

199 ion of labelled protein, which has important implications for the development of future PALM tags.

200 the tumor suppressive sirtuin SIRT6 and its implications for the development of hepatocellular carci

201 These findings have broad implications for the development of new therapeutic agen

202 erent types of reactive states has important implications for the development of new therapies for CN

203 oteasomal ubiquitin receptor, and have major implications for the development of novel anticancer the

204 These insights have implications for the development of novel modulators of

205 These findings have implications for the development of selective allosteric

206 mune system, and metabolism, and discuss the implications for the development of stromal compartment-

207 rominent deficit in the db/db model and have implications for the development of therapies for periph

208 ssification of lymphoma and have significant implications for the diagnosis and clinical management o

209 Overall, our findings have potential implications for the early detection and prevention of E

210 e attendant support studies may have further implications for the expanding use of low-valent group 9

211 MIR features have implications for the formation of simple and complex rea

212 s how these differences might have important implications for the functional consequences of noncodin

213 The reasons for this trend and the implications for the future trajectory of TB in the US r

214 These findings have implications for the health of women and their infants,

215 The projected losses have serious implications for the hydropower, municipal and agricultu

216 These findings have important implications for the identification of nutritional risk

217 This novel pathway has implications for the initiation of immune responses both

218 nem resistance in Escherichia coli has major implications for the management of common infections.

219 This has important implications for the management of these patients.

220 high affinity and specific transporters has implications for the marine phosphorus redox cycle, and

221 Our results have important implications for the marine-terrestrial biodiversity gra

222 These results have implications for the mechanisms and inhibition of MBLs b

223 Our findings have implications for the molecular mechanisms of PP, STN1 an

224 assic GPCR ternary-complex model, with broad implications for the multiplicity inherent in signaling

225 These results have implications for the nature of the neural code and ventr

226 hotoreceptors-and visual perception and have implications for the neural locus of the cone-specific c

227 These results have implications for the next-generation design of receptors

228 e mode of epitope recognition with potential implications for the outcome of sequential exposure to h

229 These results have implications for the pancancer use of targeted drugs and

230 These findings have important implications for the pathogenesis of TNF-mediated entero

231 l role of misato (mst) in Drosophila and its implications for the pathogenesis of VM.

232 portions of the gastrointestinal tract, with implications for the pathophysiology of gastrointestinal

233 Overall, our findings have implications for the planning of therapeutic and diagnos

234 The genome conservation observed also has implications for the potential success of a therapeutic

235 Our findings have therapeutic implications for the prevention and treatment of food al

236 benulopeduncular system that has significant implications for the proposed function of the IP in a va

237 ocean-atmosphere system, likely had profound implications for the rate and magnitude of the end-Trias

238 This reactivity has important implications for the recently developed dual Ni/photored

239 We further discuss the implications for the rest of the gasdermin (GSDM) family

240 iple of nutrient-dependent fitness costs has implications for the stability of cooperation in pathoge

241 y in the disease process, and have important implications for the stage of disease where trials of an

242 he same patient has critical and encouraging implications for the success of future targeted therapie

243 duction velocity, which potentially has wide implications for the temporal transfer of information in

244 urrent treatment criteria may have potential implications for the timing of antiviral therapy to achi

245 g of p53 regulation and may have significant implications for the treatment of cancer and other disea

246 w conceptual framework has several important implications for the treatment of obesity.

247 tive T helper responses, which has important implications for the treatment of type 2 inflammation.

248 Our findings have important implications for the understanding of compartmentalized

249 This has implications for the understanding of hallucinations in

250 Our findings have important implications for the use of Adelie penguins in Southern

251 Implications for the use of CP 3 in electronic devices a

252 d centrosome separation that has therapeutic implications for the use of PLK1 inhibitors in the clini

253 r a wide range of studies and have important implications for the use of zebrafish in modelling human

254 lives of these apes, with potentially major implications for their broader evolutionary biology.

255 magnetism for their dispersal, with possible implications for their evolution.

256 in a context-free manner and have important implications for theories of reinforcement learning and

257 pathways in liposarcoma, some with immediate implications for therapeutic exploration.

258 These findings have implications for therapeutic strategies that target IL-1

259 report evidence challenging this view, with implications for therapeutically targeting Mdm2.

260 l health, which may have broad translational implications for therapeutics aimed at improving islet f

261 ace in living animals, and we comment on its implications for timescales of host-microbe interactions

262 f Gata2 influence fate establishment and has implications for transcription factor-related hematologi

263 ploying life cycle-specific sterols and have implications for treatment.

264 e relevant than previously thought, and have implications for tree population responses to future env

265 We discuss potential implications for trial design based on this framework.

266 een microchimerism and split tolerance, with implications for tumor immunity, transplantation, autoim

267 cells, a gain of stemness may have profound implications for tumour aggressiveness and clinical outc

268 brain shrinkage and regrowth, with important implications for understanding adaptations to changing e

269 creased understanding of the DLK pathway has implications for understanding and treating neurodegener

270 These new findings have important implications for understanding D-serine-mediated N-methy

271 This presents implications for understanding dopamine processing of mo

272 f lacrimal gland development that have broad implications for understanding epithelial organogenesis.

273 Our findings have implications for understanding how discrete amygdalar CR

274 gulating EGFR neddylation has broad-reaching implications for understanding how homeostasis is achiev

275 e, I review these accounts and discuss their implications for understanding how predictions of the se

276 These novel findings not only have implications for understanding how this important class

277 These results have implications for understanding how viruses manipulate th

278 e theory of numerical development along with implications for understanding mathematics disabilities.

279 Although this shift may have important implications for understanding mental disorders, such as

280 These findings have implications for understanding mineral controls on As cy

281 ogy, immunology, and pathogenesis, and their implications for understanding natural infection and cur

282 of considerable interest and has significant implications for understanding patterns of diversificati

283 These findings have broad implications for understanding receptor tyrosine kinase

284 These findings have implications for understanding the causes and consequenc

285 he findings reported here have also critical implications for understanding the extremes of Earth's b

286 dological and empirical insights, with broad implications for understanding the functional and cultur

287 sin is a mechanochemical motor has important implications for understanding the mechanisms of chromos

288 or TDP-43's physiological functions, and has implications for understanding the mechanisms promoting

289 oemotional brain function and behavior, with implications for understanding the neurogenetic bases of

290 e defence is species specific, and they have implications for understanding the pattern of Bd populat

291 or nonfunctional forms of Env has important implications for understanding the role of neutralizing

292 te roles of additional H3.3 residues and has implications for use in other developmental systems.

293 imized by manipulating Ag presentation, with implications for vaccine design.

294 d quality of T cell immunity, with important implications for vaccine design.

295 iform shape at high purities has significant implications for various applications in biological rese

296 Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis

297 CO2 concentrations rise, having global-scale implications for water balance, carbon storage, and rela

298 umption, and greenhouse gas emissions, their implications for water conservation have not been widely

299 Our results have important implications for water isotope heterogeneity in plants a

300 These results have important implications for ZIKV vaccine development and provide a