ライフサイエンスコーパス: implication for

1 This new knowledge has implications for a broad range of tumours that develop w

2 Implications for a neural common currency of information

3 es across the microtubule lattice, which has implications for a range of cellular activities, includi

4 These data have implications for acute and chronic conditions that are d

5 and their biofilm propensity, has important implications for AD.

6 nts in clonal haematopoiesis and the related implications for affected patients and their providers.

7 Twitter is unprecedented, but the underlying implications for agenda setting are poorly understood.

8 This work has strong implications for an accurate assessment of the reactivit

9 This has important implications for analytical methods based on extraction

10 Our work has broad implications for anti-Alzheimer's research and drug deve

11 ase its neuroprotective functions, which has implications for anti-parkinsonian therapy.

12 This result has implications for antibody recognition of MPER prior to a

13 geneity of intralesional drug PK, have major implications for antimicrobial drug development.

14 units and on specific shifts, with possible implications for aspects of service design, and high rat

15 of lymphocyte activation and signaling, with implications for B cell immune response and BCR-dependen

16 oles of nucleoid-associated proteins and the implications for bacterial cell biology.

17 social behavior, with potential far-reaching implications for behavioral epigenetics.

18 This may have relevant implications for benchmarking processes and quality impl

19 oteins for lysosomal degradation, with broad implications for biochemical research and for therapeuti

20 s of ducks in nature, our results have major implications for biodiversity conservation and invasion

21 gulates metabolic mechanisms in B cells with implications for bioenergetic and metabolic pathways tha

22 y within the physical space of a tumor, with implications for biomarker evaluation and immunotherapy

23 I also discuss implications for biosignatures and technosignatures.

24 weather has variable and potentially strong implications for birds at different time scales, but the

25 combustible tobacco in vascular disease and implications for blood-brain barrier dysfunction and cog

26 ractions, PSA-binding ligands have important implications for both biological processes and biotechno

27 ity of blood culture for enteric fever, with implications for both clinical care and surveillance.

28 Our observations have implications for both fork restart and the division of l

29 Together, these findings present novel implications for both future scientific investigations a

30 ffects of non-nitrate components of BRJ have implications for both interpretation of previous finding

31 These motifs are highly specific with implications for both signal processing within the retin

32 These results have strong implications for Brain Machine Interface applications an

33 nsure taxonomical differentiation, which has implications for BW quality assessment.

34 Our results have important implications for cancer biology because oxidized purines

35 These findings could have broad clinical implications for cancer patients.

36 cancer and anti-tumor immune response, with implications for cancer therapy.

37 les has important prognostic and therapeutic implications for cancer treatments, but the process is v

38 ethnicity of the human host, which may have implications for carcinogenicity.

39 nt in ferrocenyl mixed-valent compounds, and implications for catalysis as well as electronic communi

40 g of cerebellar processing and have critical implications for cerebellum's role in cognitive control.

41 ated infections and diseases, with important implications for childhood mortality particularly in low

42 nderpinning spontaneous CLL regression, with implications for CLL treatment.

43 These results have important clinical implications for CNS drug delivery and clearance of CNS

44 tion of mast-seeding plants, with subsequent implications for community dynamics.

45 f PCM needed to duplicate the centriole with implications for congenital heart disease mechanisms.

46 These results have strong implications for controlling the selectivity of photoche

47 il formation, with insights that have direct implications for deducing the molecular progression of n

48 n of mutations with aging/maturation and has implications for delayed reproduction in modern human so

49 left- and right-wing activism hold critical implications for democratic practice, social media gover

50 nding "barcode" hypothesis and has important implications for design of functionally selective GPCR-t

51 energy-storing charge-separated states have implications for designing and controlling PCET reaction

52 ependent of whether they develop MIS-C, with implications for developing age-targeted strategies for

53 hat drive FBRs in the CNS and have important implications for developing effective biomaterials for C

54 hts into antigen cross-presentation and have implications for development of approaches to modulate i

55 a DNA repair protein for efficient NHEJ with implications for development of resistance to cancer the

56 These findings may have important implications for devising therapies to treat UBQLN2-link

57 ted forms of alphasyn in various models with implications for disease progression; 4) assess uniquely

58 dentify a critical time point with important implications for downstream IAV and zoonotic transmissio

59 n the integrase active site can have notable implications for drug binding and design and provide mec

60 hours spent at higher wind speeds, which has implications for dust emission potential.

61 FASs in a freshwater food web with potential implications for ecological and human health.

62 these animals changed during growth and has implications for ecology and skull development that go b

63 This study may have implications for EE-exposure risk for genetically lupus-

64 ons of dietary diversity suggest contrasting implications for efforts to predict how consumers will r

65 This process has important implications for embrittlement and subsequent degradatio

66 ive molecular crystals can have far-reaching implications for emerging fields such as smart microelec

67 ations for this conclusion hold a remarkable implication for erasing racial disparity in PCa.

68 These events have many astrophysical implications; for example, they may lead to the creation

69 c homogenization, our results have important implications for fisheries managers weighing the costs/b

70 Our results have important implications for forecasting mangrove carbon dynamics an

71 nitoring of adherence and (e) discussing any implications for further education and work.

72 rodevelopmental trajectories in TS and carry implications for future applications aimed at predicting

73 This has meaningful implications for future clinical trials and correlative

74 and stabilize excess protons, with critical implications for future drug design efforts.

75 nto the Nigerian HIV-1 epidemic and may have implications for future HIV-1 prevention strategies in N

76 e the benefits of these algorithms and their implications for future immunotherapies.

77 Implications for future studies are discussed.

78 states reveal a dynamic tunnel lining, with implications for gating or substrate translocation.

79 ience understanding of status perception and implications for gender- and status-based impression for

80 ntenance and function of the nucleolus, with implications for gene regulation and ribonucleoprotein p

81 e and effectiveness of HR sub-pathways, with implications for genome instability and cancer.

82 The results have wide-ranging implications for global ecology and for anticipating cha

83 These results have general implications for governing global good or bad commons.

84 Direct implications for gratitude interventions were discussed.

85 The results could have implications for harnessing ISG responses to reduce tran

86 These data have important implications for HCC surveillance in cured HCV patients.

87 mon in chronic disorders and has significant implications for health.

88 , the developed technique may have important implications for high resolution 3D cell imaging in the

89 use of sea ice as a predator refuge also has implications for how bowhead whales, and likely other ic

90 These results have broad implications for how collisional processes may affect pl

91 ider carbohydrates, this study has important implications for how ecologists consider nutrient limita

92 These findings have important implications for how reverse genetics can be scaled in c

93 ng strains can drive parasite assembly, with implications for how strain diversity is spatially and t

94 n Gli3 and Hox13 paralogs that has important implications for Hox and Gli3 gene regulation in the con

95 V E7 impairs differentiation has significant implications for HPV-mediated carcinogenesis and the HPV

96 of fecal sterols in mammals, and consequent implications for human health.

97 es various toxicities in mice with important implications for humans.

98 This has important implications for identifying Ag-specific T cells of inte

99 These findings have significant and broader implications for immunity and vaccine development agains

100 iomarkers of near-term pregnancy would carry implications for improved monitoring of the annual fecun

101 standing how this decision is made has major implications for improving cancer treatments, particular

102 opulation in China, which may have important implications for improving mental wellness among the pub

103 pical Indo-Pacific climate coupling-may have implications for improving seasonal and decadal predicti

104 apid mass loss to the ocean would have clear implications for increasing the rate of global sea level

105 tic-Boreal ecosystems, which has significant implications for interactions and feedbacks between terr

106 in regulating ILC3 biology and consider the implications for intestinal immunity.

107 and cell-matrix adhesion, all with important implications for intracellular signal transduction, cell

108 ance-dependent CPET reactions have potential implications for long-range charge transfers.

109 These findings have potential implications for long-term cardiac surveillance and up-f

110 specific chromatin regulators, and this has implications for long-term organism preservation.

111 us and non-Indigenous people, with potential implications for long-term PCV impact in comparable sett

112 us and non-Indigenous people, with potential implications for long-term PCV impact in comparable sett

113 sample a range of conformational space, with implications for maintaining virion stability and infect

114 Our study has direct implications for managing fisheries targeting transbound

115 dependent epizootic population control, have implications for managing lionfish and impacted native s

116 This new SMI-SMA strategy has significant implications for manufacturing high-performance fibrous

117 hallenge, but such information has important implications for microbially enhanced energy recovery.

118 4) emissions to global change with important implications for modeling greenhouse-gas dynamics of blu

119 These results have important implications for modeling SOA formation and growth in th

120 Our results have important implications for modeling species distribution and resil

121 upstaging from MR image assessment may have implications for modification of treatment.Keywords: MR-

122 The answer has profound implications for molecular evolution and our ability to

123 ing puzzles in archaeological research, with implications for more sustainable use of marginal region

124 m of acquired MEKi resistance, with clinical implications for MPNST patients harboring NF1 alteration

125 on, suggesting that viscoadaptation may have implications for multiple biophysical processes in the c

126 onal centrality measures and has significant implications for network-based interventions.

127 This finding, with deep implications for neuroscience and theory of neural netwo

128 Their competition has great implications for nitrogen loss, conservation, and greenh

129 nes to hydroperoxy amides may have important implications for nucleation and growth of atmospheric se

130 Gaps were identified in the literature for implications for nursing practice and the nursing workfo

131 Our results have wide-ranging implications for optimising antitrypanosomal drugs and a

132 Our findings could have wider implications for other actin-bundling proteins that cont

133 Further, primary cilium transience may have implications for other Hh-mediated events in development

134 gency setting in Cox's Bazar, which may have implications for other humanitarian settings.

135 function in posterior cortical atrophy, with implications for our pathophysiological understanding of

136 These findings have implications for our understanding and clinical evaluati

137 r SAB assay calibration and have significant implications for our understanding of discordance in pre

138 in somatosensory cortex, which has important implications for our understanding of information proces

139 This has important implications for our understanding of the evolution of v

140 mal human tissues, and here we discuss their implications for our understanding of tumorigenesis.

141 Increasing iodine emissions have implications for ozone radiative forcing and possibly ne

142 xtragalactic jets is currently unknown, with implications for particle acceleration, jet formation, j

143 int the hierarchy of T cell clone sizes with implications for pathogen defense and autoimmunity.

144 These findings have important implications for patient counseling and care planning, a

145 ed pathological staging systems and may have implications for patient stratification in future clinic

146 ally, the finding of a BRCAm has significant implications for patients and their families in terms of

147 The implications for patients with premorbid low/high blood

148 These determinations have important implications for patients' informed consent rights, clin

149 to methylation variability in mammals, with implications for phenotypic variation and putative parad

150 y threatened by climate change with seasonal implications for photosynthesis and forest growth.

151 Variation in K(S) has implications for plant transpiration and photosynthesis,

152 Implications for policy and research are relevant beyond

153 rstanding of leaf development have important implications for potential improvement of crop water use

154 They also may have important implications for prebiotic chemistry.

155 lation in the JE and have potential clinical implications for prevention and treatment of periodontit

156 nced the composition of available prey, with implications for prey selection, demonstrating how human

157 by modulating the cellular environment, with implications for protein design and combatting antibioti

158 s house a GABA signaling pathway with direct implications for psychiatric disease origin.

159 dopamine D2 receptor trafficking, which has implications for psychiatric disorders involving dysregu

160 cation in the aerobiome could have important implications for public health and for the design, engin

161 The implications for public health are twofold, as these pro

162 Chronic pruritus (CP) has considerable implications for QOL.

163 umentation accuracy and utility and may have implications for quality of care and patient-provider re

164 anisms of angle narrowing and have important implications for quantitative assessments of angle closu

165 diated by GABA(B) dimers, and have important implications for rational drug design that targets these

166 These findings have implications for rational protein design and synthetic b

167 These findings have implications for recreational and medical use of exogeno

168 stem cells (iPSCs) would have broad reaching implications for regenerative medicine.

169 d to myosin-7a, this work also has important implications for research on myosin-7a and hereditary de

170 is associated with burnout and has negative implications for resident wellbeing; interventions to re

171 This outcome has important implications for risk assessment and the migratory succe

172 -driven structural perturbation of CaM, with implications for RyR regulation and the decay of muscle

173 nst aging-induced atrophy, our findings have implications for sarcopenia.

174 c mechanism with etiological and therapeutic implications for schizophrenia.

175 major unsolved problem in biochemistry with implications for several human diseases, biotechnology a

176 rane for RBC shape maintenance may also have implications for shape maintenance in different cell typ

177 les such as amino acids, which has important implications for SIMS imaging of metabolites and pharmac

178 memory breaks down and may have considerable implications for stress-related psychopathologies, such

179 These findings may have important implications for studies of coronavirus-induced disease.

180 trumentation and technique advancements have implications for surgeon workload and human-systems inte

181 ns, particularly in Western cohorts, despite implications for surveillance, prognosis, and treatment.

182 and high-latitude ecosystems, with important implications for survival and distribution of species th

183 G12D tumors by immunotherapy and has general implications for T cell-based immunotherapies.

184 tween the expanded Htt allele and Hdac2 with implications for targeting transcriptional dysregulation

185 hibit TEAD palmitoylation and have important implications for targeting Wnt and Hippo signaling in hu

186 ate change in agriculture and reveal diverse implications for terrestrial ecosystems; the strong attr

187 overlapping ligand recognition and may hold implications for TH and PPAR pharmacology.

188 However, the precise quantities and the implication for the elicitation of anaphylaxis remains t

189 These findings have significant implications for the application of genome editing in bo

190 Rapid climate change has wide-ranging implications for the Arctic region, including sea ice lo

191 c and unpredictable manner; this finding has implications for the assessment of cavitation resistance

192 xing and recycling, which has very important implications for the chemical and isotopic determination

193 phere more quickly over time, with important implications for the climate-carbon cycle feedbacks.

194 n APC mutant colorectal cancer and also have implications for the clinical development of highly sele

195 o the defensive survival circuits, which has implications for the comprehension of highly prevalent p

196 tween cheetah subspecies, and have important implications for the conservation of A. j.

197 plication in the upper respiratory tract has implications for the containment of COVID-19.

198 These results have important implications for the current gene therapy strategy for L

199 Further, the results reported here have implications for the design of beta sheet proteins with

200 Our reprogrammable system has prospective implications for the design of granular materials in a m

201 This has implications for the design of new long-residence-time T

202 0 and CD70 signaling in cDC1s and have major implications for the design of new vaccination strategie

203 This could have important implications for the development and application of both

204 derstanding of tuberculosis control and have implications for the development of both therapeutic and

205 ) memory T cell pool, with potentially broad implications for the development of immunotherapies and

206 n impact on tumor progression, and will have implications for the development of more selective PARP-

207 eoelectronic phenomenon with many conceptual implications for the development of organic functional g

208 rives neurodegeneration in AD and has strong implications for the development of precise therapeutic

209 t and depression among psychiatrists and has implications for the development of targeted interventio

210 tigen recognition by TCRs and have important implications for the development of TCR-based therapies.

211 inflammatory diseases is anticipated to have implications for the development of treatments that targ

212 for the Pliensbachian and Sinemurian, giving implications for the duration of the Hettangian Stage.

213 For each scenario, we discuss its implications for the dynamics of herd immunity and on pr

214 olecular determinants of severe UTI and have implications for the early detection of this pathogen.

215 erstood life history behaviors has important implications for the ecology, evolution, and conservatio

216 ological culture but it fails to discuss the implications for the emergence of cumulative cultural ev

217 th stable coronary heart disease and discuss implications for the evaluation of patients with stable

218 l fraction and susceptibility estimates have implications for the expected global burden of COVID-19,

219 Such findings have major implications for the final production of a clinical HIV

220 ging behaviour and cognition, which may have implications for the future protection of pangolin habit

221 ead to biological discoveries with important implications for the genetics of complex human diseases.

222 radients of climate and biogeochemistry with implications for the geography of plant-consumer interac

223 mmunologic response, and has direct clinical implications for the management and follow-up of patient

224 Our findings have implications for the management of neurological disorder

225 Our findings have important implications for the management of obesity-mediated AF i

226 Our findings have serious implications for the management of PCB contamination in

227 These findings have implications for the molecular and cellular mechanisms o

228 These findings have implications for the need of continued protective measur

229 C. difficile has shifted, and this may have implications for the optimal diagnostic strategy for and

230 Our data have implications for the organizing principles that govern a

231 and changes to anti-predator behavior, with implications for the outcome of ecological interactions

232 e in neurodegeneration in EAE with important implications for the pathogenesis of MS.

233 nic connections: a conclusion with potential implications for the phylogenetic placement and palaeoec

234 stal growth during amelogenesis, and hint at implications for the preservation of biomarkers during t

235 Our findings may have relevant implications for the prevention and management of CTEPH.

236 The abiotic H(2) sink we identify has implications for the productivity of subseafloor microbi

237 The implications for the proposed use of mackinawite as a sc

238 These findings may have implications for the regulation of ghrelin function in v

239 These results have implications for the safe and effective production of no

240 nt-elicited cellular immunity and have clear implications for the screening and evaluation of novel a

241 This finding has implications for the severe genetic disorder, Barth synd

242 s of trophic interactions also has important implications for the spatial dynamics of communities as

243 ning of an oscillatory circuit and has broad implications for the spatiotemporal regulation of signal

244 cocorticoids in eosinophilic disorders, with implications for the study of glucocorticoid resistance

245 These results have profound implications for the study of this key GTPase in cancer,

246 attenuated virus vaccines and have important implications for the success of next-generation OPV.

247 to the Earth's upper mantle, with important implications for the transport of carbon in aqueous flui

248 etic nerve landscape within the cornea, with implications for the treatment of blinding corneal disea

249 t in all crystallin proteins, with potential implications for the understanding of crowding effects i

250 These results have critical implications for the use of liquid biopsies to monitor c

251 gassing of planetary interiors has important implications for their corresponding atmospheres.

252 nts require specialised life-long care, with implications for their families.

253 gnostic tool for CNS lymphoma with potential implications for theranostic approaches as well as respo

254 This has clear implications for therapeutic interventions that are desi

255 These findings have important implications for therapeutic targeting in acute lung inj

256 ow transcription of these repeats occurs has implications for therapeutics in multiple diseases.

257 of TPCs with disease progression, and their implications for therapy.

258 dy has a range of conservation and taxonomic implications for this species.

259 signature of positive selection and may have implications for tissue or cell-specific expression of t

260 c competence of faster-living hosts also has implications for trade-offs between pathogen virulence a

261 This perspective has critical implications for treatment.

262 tabolic subphenotype in women with RCC, with implications for tumor progression and outcomes in CRC p

263 component of tumor metabolism, with profound implications for tumorigenesis and treatment response.

264 nction of terminal web myosin and hold broad implications for understanding apical morphogenesis in d

265 Our study also has notable implications for understanding canonical and snRNA 3'-en

266 s between brain and systemic health and have implications for understanding contributions of the latt

267 tion in the ligament, which may have broader implications for understanding control of collagen miner

268 These findings have implications for understanding cortical malformations in

269 tivity in ice-marginal environments and have implications for understanding cultural connections acro

270 This model has important implications for understanding cytoadherence of infected

271 mutations in silico is a challenge that has implications for understanding diseases as well as indus

272 This study has implications for understanding how GBA1 mutations influe

273 The research has widespread implications for understanding how genetic diversity imp

274 These findings have implications for understanding how social biases filter

275 old mouse HSCs and progenitors, with broader implications for understanding mechanisms for stem cell

276 HSV infection of DRG neurons, which may have implications for understanding of the mechanisms of viru

277 roles of these enzymes, these findings have implications for understanding physiological and patholo

278 ding B cell biology, but also have important implications for understanding tetraspanin function gene

279 more complex than currently recognized, with implications for understanding the character evolution i

280 These results have implications for understanding the etiology and treatmen

281 to identify neuron types and have important implications for understanding the functional role of co

282 vated ion channel families and discuss their implications for understanding the mechanisms of mechani

283 d in vivo, and thus this work has widespread implications for understanding the mechanisms that regul

284 on with an aversive stimulus, with potential implications for understanding the neural basis of traum

285 The results have important implications for understanding the origin of ultra-relat

286 of somatic cell populations and discuss the implications for understanding the origins of senescence

287 Implications for understanding the pathogenesis of BTHS

288 nt role in inhibitory feedback, and may have implications for understanding the relative contribution

289 These findings have implications for understanding the role of the tumor mic

290 syncratic cortical topographies, and discuss implications for understanding the structure of cortical

291 These findings have significant implications for understanding why a hypomorphic loss of

292 This coculture technology can have broad implications for use in studying MSC-immune interactions

293 nagement in the recent past, there are great implications for using nanotechnology in immuno-oncology

294 ertoire and ensuing antibody responses, with implications for vaccination approaches and schedules.

295 etitive landscapes for B cells in vivo, with implications for vaccine design.

296 tective immunity, which could have important implications for vaccine development against flagellated

297 ture viral threats, also mentioning possible implications for vaccine development.

298 ance of this variant in viral spread and its implications for vaccine efficacy and antibody therapy.

299 udying these microbial metabolites and their implications for viral pathogenesis and treatment.

300 nts, leading to geographically heterogeneous implications for Wood Frogs.