ライフサイエンスコーパス: import

1 precursor and cleavage, resulting in nuclear import.

2 ergy accumulation and increase in methionine import.

3 say, which we propose facilitates preprotein import.

4 iration, mitochondrial dynamics, and protein import.

5 ning, as did inhibiting MCU-mediated calcium import.

6 e translocase, impedes both protein and tRNA import.

7 ary mechanism of excessive myocellular lipid import.

8 units, one of which is essential for protein import.

9 rt but not Gpd1 homodimer import and Pnc1 co-import.

10 Gpd1 homodimerisation also restores Pnc1 co-import.

11 lecular transport, and increases YAP nuclear import.

12 lay a direct role in facilitating preprotein import.

13 resting CD4 T cells at the level of nuclear import.

14 mainly in DNA maintenance and mitochondrial import.

15 tify small molecules that attenuated protein import.

16 zed auxin precursor, and peroxisomal protein import.

17 have an alpha-helical structure for protein import.

18 substrate recognition and efficient protein import.

19 ouple mitochondrial tRNA import from protein import.

20 ds (CT51), which is required for PTS protein import.

21 not prevent Gpd1 import but prevents Pnc1 co-import.

22 king it accessible for importins and nuclear import.

23 t arrangement of protein domains involved in import.

24 ation channel prevents both protein and tRNA import.

25 as 1 minus the proportion of cases that are imported.

26 The endobacterium obtained nitrogen by importing a variety of nitrogen-containing compounds.

27 he prolyl-3,4-dihydroxylase Ofd1 and nuclear import adaptor Nro1 regulate the hypoxic response in fis

28 Mitochondrial ATP-Mg/Pi carriers import adenine nucleotides into the mitochondrial matrix

29 rypanosoma brucei lacks tRNA genes, and thus imports all tRNAs from the cytosol.

30 ting from a failure of the brain to properly import amino acids.

31 We import, analyse, curate and integrate a diverse collecti

32 eracts with the mitochondrial oxidoreductase import and assembly protein 40 (AtMIA40), forming a prot

33 tosolic/nuclear compartment, binding iron at import and delivering it to enzymes, for storage (ferrit

34 tes that do invade are defective in nutrient import and die.

35 s tuned by reciprocal control of glutathione import and Ero1 activation.

36 ev and related viral proteins balance strong import and export activities in order to achieve optimal

37 By collating and comparing production, import and export data from international and national s

38 ation of morphology and trafficking, protein import and export, and other specialized processes.

39 bstrate is used to directly modulate nuclear import and export, thereby regulating the reporter's dis

40 ased user-interface for configuring the data import and for querying the database.

41 and levels likely depends on ER glutathione import and GSSG export.

42 ngly accumulate upon defective mitochondrial import and impaired proteostasis.

43 We found that during its mitochondrial import and maturation NDUFB10 transiently interacts with

44 uclear export which otherwise dominates over import and nuclear translocation of AR as a transcriptio

45 argely cryptic, mechanisms for protein/lipid import and organelle inheritance during parasite replica

46 photransferases that couple the simultaneous import and phosphorylation of a variety of sugars to the

47 s Gpd1 monomer import but not Gpd1 homodimer import and Pnc1 co-import.

48 ill be examined as the candidate ontology to import and replace eligible EFO cell line classes thereb

49 f a cellular factor necessary for L1 nuclear import and retrotransposition.

50 serves a dual function to facilitate nuclear import and simultaneously protect unassembled RpL4 from

51 ifications are important for histone nuclear import and subsequent chromatin assembly.

52 most important karyopherins for Rrp6 nuclear import and the nuclear localization signals recognized b

53 Reduced Arctic silicate import and the projected hemispheric-scale climate chang

54 end our understanding of chloroplast protein import and the role played by the import machinery compo

55 Reduced crude oil imports and associated marine vessel emissions cause add

56 At-NPF6.3 imports and senses nitrate and is regulated by phosphory

57 ylates import receptors, supports preprotein import, and contributes to efficient chloroplast biogene

58 ed cells during cytoplasmic transit, nuclear import, and mRNA synthesis.IMPORTANCE The fates of HIV-1

59 results support a model whereby Gpd1 may be imported as a monomer or a dimer but only the Gpd1 dimer

60 From in vitro import assays, mitochondria lacking Osm1 display decreas

61 Small molecule mitochondrial import blockers of the Carla Koehler laboratory (MB)-10

62 he PTS1 import pathway supports Gpd1 monomer import but not Gpd1 homodimer import and Pnc1 co-import.

63 Blocking mitochondrial import but not proteasome activity causes a marked delay

64 Gpd1 homodimerisation does not prevent Gpd1 import but prevents Pnc1 co-import.

65 he primary role of regulating Dorsal nuclear import, but also has a secondary role in shuttling.

66 nistic insights into outer membrane nutrient import by members of the microbiota, an area of major im

67 Some proteins lacking a PTS are imported by piggy-backing onto PTS-containing proteins.

68 vely charged, N-terminal presequence and are imported by the TIM23 complex (presequence translocase)

69 t chaperones or karyopherins responsible for import can maintain the stability of ribosomal proteins

70 uced selectivity properties, reduced protein import capacity and they render the Tim23 channel insens

71 Countries strongly linked by movements of imported cases are grouped by historical, language, and

72 Imported cases to non-endemic countries often result in

73 on accounting for 56% (13 947/24 941) of all imported cases to non-endemic countries with a reported

74 provinces were identified, and the number of imported cases was significantly associated with the vol

75 at both types of macromolecules use the same import channel across the outer membrane.

76 s, is not able to use alternative systems to import cholesterol in the analysed culture conditions.

77 led citrate transporter, plays a key role in importing citrate from the circulation into liver cells.

78 proteins and interact with the mitochondrial import complex.

79 The mitochondrial import component Mim1 forms a channel that is predicted

80 alteration of mitochondrial replication and import components, suggesting the involvement of additio

81 of CTR1, the high affinity transporter that imports copper into the cell.

82 ODG can import definitions and annotations from other sources su

83 However, while tRNA import depends on the core subunits of the protein impor

84 single ATPase, MceG, each system appears to import different fatty acids or sterols.

85 f the 102 consecutive DSAEK procedures using imported donor corneas performed at a single university-

86 DSAEK with imported donor corneas provides rapid and good visual re

87 mated endothelial keratoplasty (DSAEK) using imported donor corneas.

88 he necessity of performing keratoplasty with imported donor corneas.

89 and in mutant koc1 chloroplasts, preprotein import efficiency was diminished.

90 ntified importin 8 as a factor that directly imports eIF4E into the nucleus.

91 res by up to 1 degrees C because the need to import energy is offset by local generation.

92 generate enough energy to negate the need to import energy, and thereby reduce air temperatures.

93 Cities import energy, which in combination with their typically

94 This is possible by importing enormous amounts of energy and materials requi

95 -affinity substrate-binding protein (SBP) to import essential micronutrients.

96 excess of zinc is toxic, therefore dedicated import, export and storage proteins for tight regulation

97 d that miR-128 targets the 3' UTR of nuclear import factor transportin 1 (TNPO1) mRNA.

98 bosomal proteins that did not engage nuclear import factors were targets for UBE2O.

99 ting and, in fact, is strongly enhanced upon import failure, consistent with the modification occurri

100 However, the specific biological sources of imported fauna are often difficult to identify, in parti

101 all six tested insect species, including red imported fire ants, Solenopsis invicta Buren, black impo

102 d fire ants, Solenopsis invicta Buren, black imported fire ants, Solenopsis richteri Forel, little bl

103 Potential routes of exposure included imported fomites from Azerbaijan via the patient's cohab

104 to these risks because they both produce and import food irrigated from rapidly depleting aquifers.

105 t is possible to uncouple mitochondrial tRNA import from protein import.

106 A vitamin B2 product (80% feed grade) imported from China was analysed.

107 structures can be obtained with design tools imported from DNA nanotechnology.

108 ies classified as malaria free through cases imported from endemic regions.

109 n and protein family models, which have been imported from external providers, with representations o

110 en systems that depend on goods and services imported from national and global markets to satisfy the

111 ty, suggesting that many of these cases were imported from surrounding regions with higher transmissi

112 tence levels due to a combined effect of McC imported from the cultured medium and intracellularly sy

113 e of proteins encoded within the nucleus and imported from the cytoplasm.

114 70% of mitochondrial precursor proteins are imported from the cytosol via N-terminal presequences, w

115 nome and additional nuclear-encoded proteins imported from the cytosol.

116 ntries sourcing nearly all their staple crop imports from partners who deplete groundwater to produce

117 ide imazalil, which probably originated from imported fruits.

118 d, transient inductions of iron and nitrogen import genes.

119 red for induction of nitrogen, but not iron, import genes.

120 -fold higher than required for repression of import genes.

121 hen astrocytes are placed into culture, they import glucose and release lactate, an energy-rich metab

122 tly reduced resource consumption compared to importing goods from centralized production.

123 rylate the TOC159 A-domain to enable protein import have remained elusive.

124 ctive activation, which inhibits glutathione import in a negative regulatory loop.

125 s functions in cargo binding and PTS protein import in human cells.

126 eracting partners that still support protein import in moss cells, but are orthogonal to the naturall

127 phenocopied by genetically inhibiting copper import in tumors, which was linked to a reduction in MAP

128 acute infection complicated with myocarditis imported in Mainland France.

129 ential and less than 20% of these cells show import-incompetent, peroxisome-like structures (peroxiso

130 necessary and sufficient to promote protein import, indicating that trapping by Mia40 drives protein

131 mplete sampling, the delayed introduction of imported infections to Switzerland, and potential factor

132 ported series of constrained peptide nuclear import inhibitors.

133 ated into the envelope membrane in a coupled import-integration reaction that was impaired by the SEC

134 A protein import intermediate arrested in the translocation channe

135 Before their import into cilia and flagella, multi-subunit axonemal d

136 of an endogenous mechanism for nucleic acid import into mammalian mitochondria, a prerequisite for m

137 from the dark to the light in which protein import into plastids is required to rapidly complete chl

138 on with glutamine, which requires CARD11 for import into T cells.

139 er cell types, mycolactone prevented protein import into the ER of DCs.

140 H and GSSG biosensors to monitor glutathione import into the ER of yeast cells.

141 We also found that during its import into the matrix compartment, Prx1 is sequentially

142 tide that is proteolytically processed after import into the mitochondrial matrix, where it forms a h

143 und predominantly in the cytoplasm, with its import into the nucleus tightly regulated like other mem

144 In the absence of import into the nucleus, Ssd1 fails to associate with PB

145 ting sequences that are removed during their import into the organelle.

146 lopecuroidea and N. minor CA1a isoforms were imported into chloroplasts of Nicotiana benthamiana leaf

147 Here, we show that HMR can be directly imported into chloroplasts through a transit peptide res

148 proteins are synthesized in the cytosol and imported into chloroplasts.

149 Some EGT-derived proteins could be imported into chromatophores for function.

150 ds to fluorescently labeled pyoS2(NTD) being imported into FpvAI-expressing P. aeruginosa cells by a

151 Each OCT-A slab was imported into ImageJ 1.50 and digitally binarized for qu

152 spread rapidly in the Americas and has been imported into many nonendemic countries by travelers.

153 hesized as precursors in the cytosol and are imported into mitochondria by five transport pathways.

154 cytosolic proteins prone to aggregation are imported into mitochondria for degradation.

155 ete set of imaging space that are able to be imported into other imaging software programs and could

156 Volume scans were imported into software enabling grading of areas in B-sc

157 iation program during which exogenous DNA is imported into the cell and integrated into the chromosom

158 ta generated with the in-house pipeline were imported into the commercial software and used to perfor

159 cific for outer arm dynein, also fails to be imported into the flagella in the absence of the IFT46 N

160 drial proteins are nuclearly encoded and are imported into the matrix compartment where they are prop

161 compartments and showed that they were both imported into the mycomembrane and secreted into the ext

162 proteins are translated in the cytoplasm and imported into the nucleus for assembly with the rRNAs.

163 localization during the cell cycle: Cdc5 is imported into the nucleus in G2 phase and released to th

164 further show that the signalosome complex is imported into the nucleus in timed fashion to stabilize

165 y diffuse through nuclear pores were readily imported into the nucleus through this boronate-mediated

166 zed in the cytoplasm as preproteins and then imported into the organelles via specialized machineries

167 Both Hep and HS oligosaccharides imported into the periplasm were degraded by a repertoir

168 This import involves binding of newly synthesized proteins by

169 ce of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells an

170 Thus, defective glycine import is a targetable metabolic deficiency of DLBCL.

171 In chloroplasts, protein import is accomplished by the TOC (translocon on the out

172 The process of nuclear import is considered to be the bottleneck of the viral r

173 Mitochondrial tRNA import is widespread, but the mechanism by which tRNAs a

174 to its originally described role in protein import, is able to influence downstream processes leadin

175 s a carbon source in the absence of glucose, importing it via the chitin-uptake channel EcChiP for pr

176 al data on protein-protein interactions, and importing known pathways and protein complexes from cura

177 IMPORT LOW is a multicentre, randomised, controlled, pha

178 The protein import machineries of the mitochondrial membranes and aq

179 ic organization of the mitochondrial protein import machineries.

180 osolic aggregates requires the mitochondrial import machinery and proteases.

181 st protein import and the role played by the import machinery component Tic40, we performed a genetic

182 covered a novel component of the chloroplast import machinery, the regulatory kinase at the outer chl

183 available nationally reported statistics on imported malaria in the past 10 years, covering more tha

184 olved heat-shock protein 70-mediated nuclear importing mechanism.

185 st and plant homolog Icp55 processes several imported mitochondrial matrix proteins leading to their

186 nslocation and adenosine triphosphate-driven import motor activity.

187 n the inner membrane, are handed over to the import motor at the matrix face.

188 nslocase), the activity of the Hsp70-powered import motor is crucial for the translocation of the mat

189 n into mitochondria, from the channel to the import motor of the presequence translocase.

190 mutations in TM3 compromised binding of the import motor.

191 g region of Tim17 involved in binding of the import motor.

192 t legal restrictions of China in distillates import need a quick and sensitive method for their quant

193 uanosine triphosphate (RanGTP) gradient that imports nuclear localization signal (NLS)-specific cargo

194 a fashion that is independent of the nuclear import/nuclear retention of COP1.

195 O1 affects L1 retrotransposition and nuclear import of an L1-ribonucleoprotein complex (using L1-enco

196 tic ribosome biogenesis requires the nuclear import of approximately 80 nascent ribosomal proteins an

197 Four compounds were found to inhibit nuclear import of C in transfected cells, with one able to reduc

198 sence of Tom22 did not inhibit mitochondrial import of cytochrome P450scc (cytochrome P450 side chain

199 mechanisms and proteins responsible for the import of fatty acids in Mtb were previously unknown.

200 ean modeling and in silico perturbations the import of given circuit features on developmental functi

201 oplast, whereas PLGG1 alone accounts for the import of glycerate.

202 In the case of chloroplasts, the import of hundreds of different proteins depends on tran

203 The import of lipids into the chloroplast is essential for p

204 of automatic segmentation results or direct import of manually segmented cells.

205 as mitochondria and chloroplasts require the import of many proteins from the cytosol, a process that

206 mitochondria lacking Osm1 display decreased import of MIA substrates, Cmc1 and Tim10.

207 leaf litter decay are associated with a net import of N from the soil environment, and both observat

208 ly occurs intracellularly and depends on the import of oligosaccharides by an outer membrane protein

209 e export of two glycolate molecules with the import of one glycerate molecule during photorespiration

210 ogroup that was transmitted to Europe by the import of Oriental stallions.

211 Import of peroxisomal enzymes is facilitated by peroxins

212 A remarkable property of the machinery for import of peroxisomal matrix proteins is that it can acc

213 regulated crucial mtHsp70 functions, such as import of preproteins and biogenesis of Fe-S clusters.

214 However, paradoxically, import of protein bacteriocins, the mechanisms of which

215 fy protein-related entities, the large-scale import of proteoform information from expert curated res

216 ligands leads to the generation and nuclear import of PSA-lacking and -carrying NCAM fragments.

217 ned that specifically preventing the nuclear import of pSMAD3 using the TAT-SNX9 peptide inhibited pr

218 Active nuclear import of Ran exchange factor RCC1 is mediated by import

219 f yeast and human proteins linked to nuclear import of selective cargo.

220 rts a direct role for the PAM complex in the import of substrates that are laterally sorted to the in

221 e Carla Koehler laboratory (MB)-10 inhibited import of substrates that require the TIM23 translocon.

222 mechanism by which iron may be removed upon import of the holo-siderophore are presented.

223 ns through the STIM proteins and facilitates import of the ion from the extracellular space.

224 tion of a protein factor involved in nuclear import of the L1 element and demonstrates that miR-128 c

225 We speculate that nuclear import of the PIC may proceed concurrently with the norm

226 in HIV infection by facilitating the nuclear import of the pre-integration complex (PIC) that contain

227 Here, we show that the nuclear import of the PSA-carrying NCAM fragment is mediated by

228 Generation and nuclear import of this fragment in cultured cerebellar neurons i

229 Whereas the import of Tim17 depends on the binding to the IMS protei

230 Here we show that in T. brucei in vivo import of tRNAs requires four subunits of the mitochondr

231 1 is not required for either histone nuclear import or deposition.

232 ascribed to roles in either histone nuclear import or deposition.

233 e of Gram-negative bacteria that mediate the import or export of substrates and/or extrusion of type

234 Genetic perturbation of copper import or pharmacologic reduction of copper with the cli

235 actions that control the peroxisomal protein import pathway can be manipulated to create a pair of in

236 NLS and importin alpha/beta mediated nuclear import pathway has already been described for beta-DG, t

237 e the authors engineer a peroxisomal protein import pathway orthogonal to the naturally occurring sys

238 pd1 from the PTS2 import pathway to the PTS1 import pathway supports Gpd1 monomer import but not Gpd1

239 l be the implementation of a bespoke protein import pathway that can selectively deliver constituent

240 Redirection of Gpd1 from the PTS2 import pathway to the PTS1 import pathway supports Gpd1

241 rough silencing of components of the nuclear import pathway.

242 alpha/beta, transportin 1, and transportin 3 import pathways and the Crm1-mediated export pathway.

243 Diverse protein import pathways into mitochondria use translocons on the

244 roteases preferentially targeted Nups in the import pathways, while B04 and C15 proteases were more e

245 nfected people demonstrates the same bimodal import pattern in vivo.

246 Tim23 channel constitutes the actual protein-import pore wide enough to allow the passage of polypept

247 OM40, the trypanosomal analogue of the Tom40 import pore.

248 t lipid biosynthesis is largely dependent on imported precursors, resulting in a characteristic diffe

249 onogalactosyldiacylglycerol exclusively from imported precursors.

250 e protein and resulted in degradation of non-imported precursors.

251 estidae) intercepted in SWPM associated with imported products at six U.S. ports.

252 karyotic organelles that posttranslationally import proteins via one of two conserved peroxisomal tar

253 Many imported proteins are further targeted to the thylakoid

254 example, the TPR domains in the peroxisomal import receptor PEX5 enable binding to a range of type 1

255 ntial protein TOC159 functions thereby as an import receptor.

256 translocase, it does not require the protein import receptors, indicating that the two processes are

257 ent of the TOC machinery that phosphorylates import receptors, supports preprotein import, and contri

258 spread, but the mechanism by which tRNAs are imported remains largely unknown.

259 complex limits local access to iron because import requires a suitable cognate receptor.

260 Here we show that Pnc1 co-import requires Gpd1 to form homodimers.

261 t of national or regional bans, and sales or import restrictions, on the availability of one or more

262 Concurrently, Nro1 imports Rps23 into the nucleus for assembly into 40S rib

263 the distance to the initial outbreak, making import screening ever more difficult.

264 ply the absence of a need for active nuclear import, sequence and structural analysis suggests that a

265 This result implied that imported soybean has brought benefit for Northeast China

266 The Deltapsi- and Pam17-dependent import step identified in this study is positioned betwe

267 Molecular targeting is an import strategy to treat advanced colon cancer.

268 lining rate of reactivation or a decrease in imported subclinical TB - could accurately describe the

269 PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new PBD.

270 (PY-NLS)/karyopherinbeta2 (Kapbeta2) nuclear import system regulates Gli ciliary localization and Hh

271 ds on Mid1, Fig1, and a third, unidentified, import system.

272 e to Mn(II) intoxication even if both of the import systems are absent.

273 of cytosolic Ca(2+) that is mediated by two import systems composed of the Mid1-Cch1-Ecm7 protein co

274 Cellular potassium import systems play a fundamental role in osmoregulation

275 n bacteria also serve as rudimentary protein import systems, which, in the case of FpvAI, results in

276 which have been proposed to encode ABC-like import systems.

277 ns led to a decrease in expression of ferric import systems.

278 tids, bacteria do not have dedicated protein import systems.

279 ypanosoma by blocking glycosomal/peroxisomal import that depends on the PEX14-PEX5 protein-protein in

280 UBP) and a semisynthetic organism (SSO) that imports the constituent unnatural nucleoside triphosphat

281 transporter from Phaeodactylum tricornutum, imports the requisite unnatural triphosphates from its m

282 B-dependent transporter (TBDT) that actively imports the small siderophore ferripyoverdine (Fe-Pvd) b

283 Our data suggest that, during preprotein import, the Toc159G dimer disengages and the dimer inter

284 o give new insights into peroxisomal protein import, the variant receptor-signal sequence pair forms

285 dsRNAs, either degrading them or failing to import them into the cytoplasm.

286 M. tuberculosis imports these metabolites through its respective transpo

287 molecules and micronutrients, which they can import through transmembrane transporters and endolysoso

288 design feature promotes a switch from ferric import to the more physiological relevant ferrous iron u

289 We investigated whether plants imported to Ireland from the Netherlands might harbor tr

290 during the treatment of MERS-CoV infections imported to Thailand.

291 his action reduced the number of salamanders imported to the U.S. from 2015 to 2016 by 98.4%.

292 depends on the core subunits of the protein import translocase, it does not require the protein impo

293 Increased ER glutathione import triggers H2O2-dependent Bip oxidation through Ero

294 m, linking increased Fur activity to ferrous import under iron-sufficient conditions.

295 that facilitating cholesterol and fatty acid import via Rv3723/LucA is required for full bacterial vi

296 l as higher molecular weight preproteins and imported via the translocons in the outer (TOC) and inne

297 Oligomeric proteins can be imported via these pathways but evidence is accumulating

298 erstanding of how Toc159 mediates preprotein import, we mapped the preprotein-binding regions on the

299 96 and -183 in prostate cells decreased zinc import, which is a characteristic feature of PCa tumours

300 teins is the nicotinamidase Pnc1, that is co-imported with the PTS2-containing enzyme Glycerol-3-phos