ライフサイエンスコーパス: important issue

1 rpinning BRAFi-based therapy is therefore an important issue.

2 making the care of potential organ donors an important issue.

3 ts in deaths, therefore, its detection is an important issue.

4 t will shape policy makers' thinking on this important issue.

5 associated with long-term CNI use remains an important issue.

6 ation performance and choice of reference an important issue.

7 g pathways that drive Brn-2 expression is an important issue.

8 spitals in Korea, care quality has become an important issue.

9 heterogeneity of the tumor vasculature as an important issue.

10 mation from literature is challenging but an important issue.

11 s and clinical trial designs to address this important issue.

12 efore, the control of liver metastases is an important issue.

13 ween true and false positive CNAs becomes an important issue.

14 ver 90% of patients, but toxicity remains an important issue.

15 genetic disorders is needed to address this important issue.

16 last year and neuroprotection has become an important issue.

17 going trial in the UK will soon address this important issue.

18 A controlled trial is needed to examine this important issue.

19 iosides as co-receptors, we re-examined this important issue.

20 le prediction of such sites still remains an important issue.

21 that increased funding be committed to this important issue.

22 -dimensional complex dynamical systems is an important issue.

23 other types of vegetable oils has become an important issue.

24 ther allergic disease is a controversial but important issue.

25 hetic dyes in foodstuffs and beverages is an important issue.

26 take characteristics and mobility remains an important issue.

27 aper substitutes, has become an increasingly important issue.

28 he overall quality of iPSC clones will be an important issue.

29 research efforts should seek to resolve this important issue.

30 ce-supporting infrastructures have become an important issue.

31 reat patients before and after resection are important issues.

32 thesis and the catabolism of CD23 are, thus, important issues.

33 ple dyadic considerations leave out too many important issues.

34 uthors' simulations revealed two potentially important issues.

35 recent studies that shed new light on these important issues.

36 We address two important issues.

37 terations influence DSB repair processes are important issues.

38 encies in knowledge of many aspects of these important issues, a vaccine for the most important patho

39 our understanding of the condition or raise important issues about its diagnosis and treatment.

40 Here, we explore several important issues about mechanisms of redundancy, heterog

41 energy will be spent keeping fit this raises important issues about new energetic trade-offs, which h

42 The next few years should resolve important issues about the potential role of these drugs

43 ical rather than Darwinian thinking, raising important issues about the questions that are actually b

44 at all in this subset of patients, are other important issues actively under study in ongoing trials.

45 is during chondrogenic differentiation is an important issue affecting the use of stem cells in carti

46 le tumor after the end of therapy remains an important issue and is one of the major applications of

47 is Gem, I review recent data addressing this important issue and propose a testable hypothesis that c

48 field in the past few years have highlighted important issues and at the same time raised new questio

49 utism spectrum disorders (ASDs) to highlight important issues and challenges for the implementation o

50 dress each of these arguments, acknowledging important issues and clarifying some misconceptions, and

51 r the main findings from reports to identify important issues and establish recommendations for futur

52 ly progressing field by highlighting several important issues and parameters, such as the role of dom

53 This Minireview discusses some of the important issues and problems to be solved if these effo

54 Two important issues are the retinal safety of cefuroxime an

55 Important issues arise with the interpretation of these

56 associated vasculitides and to identify the important issues arisen in the adult literature.

57 This is an important issue as such dynamic changes affect exposure

58 ple-related microarray studies has become an important issue as the technology becomes mature and pre

59 Recent studies have focused on such important issues as the use of the Internet in medicine,

60 ue to computed tomography (CT) has become an important issue, as the number of CT examinations has be

61 These are important issues, as recombination errors cause cancers

62 This is an important issue because incorrectly mapped reads affect

63 en the transport and magnetic topology is an important issue because the structure of magnetic island

64 Here, we address this important issue by studying mutations of Thr77 at the de

65 We addressed this important issue by uniquely examining the intrinsic func

66 Food security is one of the most important issues challenging the world today.

67 Our data also raise important issues concerning delayed transgenerational ef

68 Nonetheless, the debate raises important issues concerning the accurate early identific

69 One important issue concerns whether repetition attenuation

70 We discuss some important issues dealing with these topics.

71 Many important issues (eg, mechanism(s) of action of stem cel

72 Important issues emerging include the organisation of fi

73 Our method addresses important issues encountered in AP-MS datasets, making R

74 To examine important issues encountered in sleep data analysis, we

75 pecific dopaminergic receptor subtypes is an important issue, especially with respect to new drug dev

76 itis C virus, viral resistance has become an important issue, essentially precluding use of protease

77 d rectum after subtotal colectomy remains an important issue even in the era of ileal pouch-anal anas

78 to TRAIL and other targeted therapies is an important issue facing current cancer research field.

79 However, this raises two important issues; first, the new HMMs should be biologic

80 ormation of ultrafast folding proteins is an important issue for both experiments and simulations.

81 rol of a microarray experiment has become an important issue for both research and regulation.

82 An important issue for chromatin remodeling complexes is ho

83 among women 40 to 49 years of age remain an important issue for clinical practice.

84 (OSPW) for return into the environment is an important issue for effective tailings management in Alb

85 may impact sensory reliability, which is an important issue for feedback control because different s

86 lability of lithium is gradually becoming an important issue for further continued use and developmen

87 ms on in vivo experiments continues to be an important issue for mice being used for biomedical resea

88 The quality of the images obtained was an important issue for OCTA, as 15.1% of scans were nongrad

89 se health professionals need to address this important issue for older adults who lose the ability to

90 The most important issue for our responders was the handling of u

91 fibre in baked goods and cereal flours is an important issue for research, nutritional labelling and

92 at these results endure over time remains an important issue for self-management interventions.

93 Animal nutrition constitutes an important issue for the animal production industry.

94 en solvents with low toxicity and cost is an important issue for the biochemical industry.

95 ssessment of GO annotation consistency is an important issue for the comparative genomics community.

96 e-immobilized ligands or binding sites is an important issue for the development of sensors, array- o

97 omineralization using protein cavities is an important issue for the fabrication of biometamaterials

98 Bread staling reduction is a very important issue for the food industry.

99 An important issue for the implementation of silicon is the

100 An important issue for the international community is how s

101 It is an especially important issue for this class of material because of th

102 ing donor liver transplantation (LDLT) is an important issue for this procedure.

103 We examined two important issues for accurate promoter prediction: (1) t

104 Two important issues for conservation are the range expansio

105 This presents two very important issues for organic chemists.

106 development (192, 18.3%) are among the most important issues for the respondents.

107 Such findings raise important issues for therapeutic advances specifically t

108 Bioterrorism and abortion were also important issues for voters.

109 One important issue frequently ignored in the literature is

110 longevity and patterns of survivorship is an important issue from several research perspectives, incl

111 of these cues has not been fully defined, an important issue given that EMT is an early event in tumo

112 es based on CO2 reduction is an increasingly important issue given the world's continued reliance on

113 nemonic and spatial processing demands, both important issues given approach-avoidance behavior in hu

114 These are important issues given the obesity epidemic and the asso

115 results in enhanced cellular specificity, an important issue has recently emerged related to the sele

116 all data sets were analyzed in replicate, an important issue ignored by most studies in the past.

117 IPV is now recognized as an important issue impacting the health of children.

118 An important issue in affective neuroscience concerns the r

119 We further address an important issue in aging research, wherein so far, the k

120 f novel morphological traits is an extremely important issue in biology, and a frequent source of thi

121 Population stratification remains an important issue in case-control studies of disease-marke

122 material instabilities during processing, an important issue in commercial metal alloys.

123 tional foods or nutraceuticals has become an important issue in current health research.

124 Voters ranked health care as the fourth most important issue in deciding their vote for president in

125 utation level variance values have become an important issue in determining the mechanisms that cause

126 Extension of the serum half-life is an important issue in developing new therapeutic proteins a

127 lly expressed in stem/progenitor cells is an important issue in developmental and stem cell biology.

128 Differences in molecular chirality remain an important issue in drug metabolism and pharmacokinetics

129 The authors have addressed an important issue in epidemiology: Often causal effect est

130 An important issue in eQTL mapping is how to effectively in

131 Flavonoid oxidation is important issue in food processing and quality.

132 An important issue in food technology is that antimicrobial

133 g genome-wide statistical significance is an important issue in genetic studies.

134 Emerging vector-borne diseases are an important issue in global health.

135 This emotion is an important issue in intensive care settings because of it

136 he identification of genotyping errors is an important issue in mapping complex disease genes.

137 To resolve this important issue in memory representation, we presented m

138 An important issue in mercury (Hg) biogeochemistry is to ex

139 Population structure is a particularly important issue in nonhuman species since it is often di

140 An important issue in parametric modeling for so many gene

141 ar juvenile idiopathic arthritis (JIA) is an important issue in pediatric rheumatology.

142 osition during wood formation is not only an important issue in plant biology but also critical for p

143 An important issue in population biology is the dynamic int

144 ele in a population is under selection is an important issue in population genetics, and various neut

145 An important issue in practical applications is the tendenc

146 Accurate detection of SAPs is an important issue in proteomic analysis at the experimenta

147 d, Safeukui et al have come to grips with an important issue in red blood cell (RBC) biology.1 Their

148 cortical activity and stimulus coding is an important issue in sensory neuroscience.

149 y transport mechanism of flares, which is an important issue in solar and plasma physics.

150 ses to proliferate or to differentiate is an important issue in stem cell and cancer biology.

151 of the knee to assess joint space loss is an important issue in studies of progression and treatment

152 otion and cognition interact, a specifically important issue in surprise research.

153 Hidden variability is a fundamentally important issue in the context of gene expression studie

154 formation of the betaine intermediate is an important issue in the control of diastereoselectivity.

155 he carbon dioxide capture is a more and more important issue in the design and operation of boilers a

156 Sample size calculation is an important issue in the experimental design of biomedical

157 Epigenetic heritability is an important issue in the field of genetics and also in the

158 ligands present in a cytosolic milieu is an important issue in the field.

159 Rapid detection of bacterial growth is an important issue in the food industry and for medical res

160 Saffron quality characterization is an important issue in the food industry and of interest to

161 heir negative predictive value represents an important issue in the management of patients who requir

162 l need to be covered to further clarify this important issue in the management of type 2 diabetes.

163 The Th1/Th2 paradigm has become an important issue in the pathogenesis of asthma, character

164 An important issue in the study of cities is defining a met

165 Resistance to current drug therapy is an important issue in the treatment of epilepsy.

166 An important issue in tissue engineering concerns the possi

167 rkers at very low concentrations have become important issues in advanced biological and chemical sen

168 lls to a metastatic state are among the most important issues in cancer biology.

169 e the application of this unbiased method in important issues in ChIP-Seq data analysis, such as data

170 We further discuss important issues in combining genomics/proteomics databa

171 One of the most important issues in computational proteomics is to produ

172 n of cooperative behavior is one of the most important issues in game theory.

173 o a better understanding of some of the most important issues in many-body physics, such as high-temp

174 This work illustrates several important issues in physical activity epidemiology regar

175 lds have considerable promise in elucidating important issues in plant domestication and in agricultu

176 This approach unveils important issues in protein design that are often camouf

177 These results have implications for important issues in protein folding studies, including l

178 This work addresses three important issues in protein-protein docking: implementin

179 eoclastogenesis and in bacterial clearance-2 important issues in S. aureus-induced joint destruction.

180 posomes should be useful for addressing many important issues in SNARE-mediated membrane fusion.

181 Important issues in stem cell biology, such as stem cell

182 In his Perspective, Heritage discusses these important issues in terms of a new report (Wilkinson et

183 and their relation to these physiologically important issues in the context of the structural inform

184 tivated rice, clarifying three ambiguous but important issues in the evolution of wild Oryza species.

185 orms in 1997, IVIVC has been one of the most important issues in the field of pharmaceutics.

186 he basic technology, candidacy criteria, and important issues in the fields of adult and pediatric co

187 cle reviews the recent literature concerning important issues in the management of patients with blad

188 ation approaches, we address two of the most important issues in these types of studies: specificity

189 Important issues include multisystem disease associated

190 Important issues include the relationship between dose a

191 We apply this methodology to look at three important issues, involving the relationships between re

192 Here this important issue is addressed by using suitable discrete

193 An important issue is consumer communication, because consu

194 Here, evidence on this important issue is evaluated, and means of obtaining rel

195 he need for research further addressing this important issue is highlighted.

196 rils is not clear, and investigation of this important issue is hindered by the unavailability of sta

197 An important issue is how cells achieve and regulate effici

198 An important issue is how normal brain aging transitions to

199 An important issue is how remission and flare are defined a

200 An important issue is that the nature and roles of the algo

201 om the diagnosis of the duplication cyst, an important issue is the detection of concomitant developm

202 guidelines or in certain settings; thus, the important issue is the management of COIs in a fair, jud

203 the transition from laboratory to clinic, an important issue is the most suitable composition of the

204 An important issue is the overall cost of cure in relation

205 The next important issue is the selectivity of G-quadruplex-inter

206 An important issue is understanding how the hippocampal pla

207 The most important issue is what results generated by these assay

208 The more important issue is whether increasing blood [GDF11] repa

209 An important issue is whether proteasomal degradation of p2

210 An important issue is whether rodent models are predictive

211 An important issue is whether Weyl physics appears in a bro

212 Raman scattering (SERS) sensors, one of the important issues is the development of substrates not on

213 ledge, limitations of previous research, and important issues meriting future investigation.

214 d progress has been substantial, a number of important issues need to be addressed before introductio

215 An important issue not only for patients but also for the w

216 his gap, this invited commentary relates the important issue of "natural direct effects" to the well-

217 Finally, we review the equally important issue of accuracy.

218 We address the important issue of formulating the null hypothesis of no

219 represents an initial attempt to address the important issue of gene-environment interactions in the

220 It addresses the important issue of how these agents may best be combined

221 arametric MRI and PET imaging to address the important issue of intratumoral heterogeneity in breast

222 The important issue of whether CC is automatic has previousl

223 The present study investigated the important issue of whether there is a decline of the GAB

224 sion of CO2 to liquid fuels, one of the most important issues of contemporary energy and environmenta

225 rmance, new model is needed to address these important issues of MeRIP-seq data.

226 Two important issues of microarray bioinformatics are first,

227 lin sheaths of the auditory nerve (AN) is an important issue particularly because these changes can b

228 er reported in the United States and discuss important issues pertaining to epidemiology, diagnosis,

229 Here we highlight the important issues raised by the new data and suggest how

230 This review summarizes important issues raised during a satellite session at th

231 An important issue regarding voluntary exercise is whether

232 of the exon 11-associated variants and raise important issues regarding the importance of atypical tr

233 evitability, this article raises a number of important issues regarding these assays that deserve con

234 Future sea-level rise is an important issue related to the continuing buildup of atm

235 Nevertheless, many important issues related to DNA binding, for example, ho

236 In this paper, we address other important issues related to succession of species abunda

237 article provides information on potentially important issues related to the off-label treatment appr

238 In the present paper, we focus on several important issues related to the topology of gene express

239 This review provides a broad overview of important issues related to WBV therapy for prevention a

240 he academic-industry relationship, including important issues relating to conflict of interest for bo

241 international perspective has been sought on important issues relating to management of the axilla, w

242 k of cardiovascular disease, but a number of important issues remain controversial.

243 Important issues remain outside the realm of electrophys

244 Important issues remain to be resolved, including the ob

245 ity due to its high charge carrier mobility, important issues remain unresolved that prevent its wide

246 egin as early as the retina itself, but some important issues remain unresolved.

247 However, important issues remain: uncertain patient selection cri

248 This is an important issue since we need to achieve a high magnetor

249 This is an important issue, since growing evidence links disease pr

250 This is an important issue, since it is likely that optimal immunit

251 for serum 25(OH)D quantitation and considers important issues such as whether both the D2 and the D3

252 heir model, while compelling, overlooks some important issues, such as mutualistic associations with

253 However, important issues, such as the precise mechanisms mediati

254 Here, we summarise important issues surrounding immunotherapy for RCC, the

255 The article highlights the current important issues surrounding the anesthetic care of pati

256 The important issues surrounding the application of stem-cel

257 recurrent copy number changes in cancer, an important issue that can be addressed using the cross-sa

258 Several authors have recently raised the important issue that FDR or pFDR may give misleading inf

259 d their potential as therapeutic targets, an important issue that has not been addressed is the impac

260 An important issue that has not been investigated is whethe

261 e in the face of progressive cell loss is an important issue that pertains to neurodegenerative disea

262 However, an important issue that remains unclear is whether the fund

263 on of a multiple sclerosis (MS) lesion is an important issue that remains unresolved, primarily becau

264 A binding to large DNA fragments, raising an important issue that requires further investigation.

265 is notable in attempting to address several important issues that challenge the field, including exp

266 fication, optimality and controllability are important issues that emerge in the discussion.

267 alance, and missing data), (2) reporting any important issues that emerge, and (3) exploring variatio

268 systemic lupus erythematosus and to identify important issues that have arisen in association with th

269 There are several important issues that need to be addressed, and foremost

270 epidemiology could prove valuable but raises important issues that need to be considered because diet

271 tion; however, it has also highlighted three important issues that require resolution.

272 ents in the Earth's climate system, the most important issue to address is how stable is the desirabl

273 ration of the therapeutic effects is another important issue to be considered, especially because the

274 al association between statins and HCC is an important issue to examine.

275 velopment of new fungicides against FG is an important issue to reduce cereal infection and economic

276 Our aim is to bring this important issue to the attention of the plant science co

277 Important issues to be addressed include improving vacci

278 xes in vivo, as this remains one of the most important issues to be resolved.

279 rodegenerative disease research, and outline important issues to consider in the transition of stem c

280 plication and functional diversification are important issues to consider in uncovering gene function

281 Important issues to consider on preoperative imaging eva

282 statins may be background specific and raise important issues to consider when contemplating clinical

283 , its origins in classic measurement theory, important issues to consider when operationally defining

284 ring for a parent in the adult child's home, important issues to consider, and a framework for clinic

285 , naive fitting procedures that ignore these important issues typically provide similarly good fits f

286 too fragmented and incremental, leaving many important issues unaddressed.

287 ty to the bandwidth measurements and leaving important issues unresolved.

288 A new study tackles this important issue using bioinformatics approaches to decip

289 However, addressing this important issue using mouse models that either overly or

290 While these important issues warrant attention, patients also need a

291 In addressing this important issue, we consider a behavior that has been pe

292 To clarify this therapeutically important issue, we have analyzed FLT3(ITD) and NPM1(MUT

293 To address this important issue, we measured the relaxation of individua

294 To address this important issue, we recorded neural activity in CA1 as r

295 To address this important issue, we utilized a genetic model of disrupte

296 Data quality is an important issue when managing food composition data sinc

297 activity and suggest that isotype will be an important issue when optimizing reagents for clinical us

298 g IDs from one database to another is a very important issue which is not properly addressed at the m

299 Important issues which are highlighted in this work are

300 Resolution of this important issue will require long-term randomized contro