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1 ion of IP cleanup to precious samples nearly impossible.
2 entification of such sensors would be nearly impossible.
3 kes any long-range prediction of the path(s) impossible.
4 e out-of-the-box sharing of that data nearly impossible.
5 overy of novel vaccines that were previously impossible.
6 l system, making clinical translation nearly impossible.
7 morphological discrimination between the two impossible.
8 h renders multiple rounds of RNA replication impossible.
9 demic work, and severing ties with it may be impossible.
10 hich makes reporting on an individual neuron impossible.
11 testing among these explanatory scenarios is impossible.
12 of such RNAs using existing methods has been impossible.
13 ng learning or altered sensory input will be impossible.
14 ch explanations is difficult or (some argue) impossible.
15 , which makes traditional genetic approaches impossible.
16 f conditions within a single species becomes impossible.
17  trismus makes detailed clinical examination impossible.
18 ate niche lineages, which would otherwise be impossible.
19 ed in a way that makes a natural origin seem impossible.
20 large molecular systems has been practically impossible.
21 e biochemical purification difficult, if not impossible.
22 routines, which makes prediction with the BN impossible.
23 aking complete removal by surgical resection impossible.
24 ous phylogeny for the superfamily has proven impossible.
25 cost make genome-scale knockdown experiments impossible.
26 identification of such variants difficult or impossible.
27 r electromagnetic fields that was previously impossible.
28 t of electromagnetic radiation is completely impossible.
29 he very broad definition of UPFDs makes this impossible.
30 o the PTC thus making peptide bond formation impossible.
31 k signals make many bio-imaging applications impossible.
32 s enormous, and testing all of them would be impossible.
33 nventional configurations that are otherwise impossible.
34 bodies for which viral escape is unlikely or impossible.
35 s often render an unambiguous identification impossible.
36 agnosis as the clinical diagnosis is usually impossible.
37 hole-genome using these approaches is nearly impossible.
38 amming begins becomes very difficult or even impossible.
39 value, beyond which natural delivery becomes impossible.
40 lyses of multiple disease states as hitherto impossible.
41 n as single-photon interferences were deemed impossible.
42 g, make enforcing quotas challenging, if not impossible [5, 6].
43                         Therefore, while not impossible, a biological catalyst would have to surmount
44 enges are such that the ideal studies may be impossible, although, for numerous factors, it has been
45 for over a year, such that photosynthesis is impossible and continents and oceans cool by as much as
46 ET is lower, but a high R0 makes eradication impossible and control ineffective.
47 er cooling, equilibration eventually becomes impossible and glass formation occurs.
48 limitations make plain model-based valuation impossible and require metareasoning strategies to appor
49 the comparison between instruments is nearly impossible and the set of measurements from the various
50 ms in 2014, making adequate care for malaria impossible and threatening the gains in malaria control
51 to treating immoral and irrational events as impossible, and provide a case study of high-level cogni
52  where accurate benchmarking is difficult or impossible, and to the importance of nonequilibrium geom
53 ave become popular as they enable previously impossible approaches of environmental observations.
54             Such identification is currently impossible, as the host risk factors that predispose ind
55 ns themselves makes such investigations near impossible, as very small changes can often make dramati
56 d diverse IMS/MS arrangements and modalities impossible at ambient buffer gas pressure were enabled a
57 Because direct detection of ionizing flux is impossible at the epoch of reionization, this represents
58 ever, direct transmission of states is often impossible because of noise and loss in the communicatio
59                 Total resection is sometmies impossible because of the rich vascularity and difficult
60 ersible control of the supercurrent has been impossible because of the robust preconfigured nature of
61 es of the pathogenicity of VA1 are currently impossible because there are no reported cell culture sy
62 toreceptors are active, but colour vision is impossible because they all use the same visual pigment.
63 port during metamorphism has been previously impossible both in nature and in experiment.
64  is, intentional - social change is not only impossible, but also undesirable.
65 rrently renders a quantitative meta-analysis impossible, but permits us to develop a deductive framew
66 ant to be exhaustive, as such an endeavor is impossible, but rather aims to balance breadth and depth
67                   This perspective tries the impossible by discussing some recent advances in the con
68 on with 100 % atom economy, but it is almost impossible by thermal catalysis owing to the significant
69  5 orders of magnitude, which is essentially impossible by using conventional fluorescent dyes.
70 junction with each other, enabling otherwise-impossible chemical transformations within primordial ce
71 d carbosulfenylation of alkenes, a seemingly impossible conundrum arose: How could a catalyst inhibit
72 pigenetic findings in these directions makes impossible demands on prospective parents and triggers s
73 ted errors were defined as missing dates and impossible discrepancies.
74 ng small bowel transplantation is frequently impossible due to contraction of the abdominal domain.
75  field modulation of spin currents is almost impossible due to negligible intrinsic spin-orbit coupli
76  and persists in immune-privileged sites was impossible due to the absence of a suitable animal model
77  specific molecular mechanisms is frequently impossible due to the extremely high degree of GAG heter
78 isease-associated non-coding SNPs is largely impossible due to the inability to accurately quantify t
79                      This would typically be impossible due to the lack of a conducting drain path fo
80 diation are highly desirable but practically impossible due to the massive size of the silicon single
81 yl iodides by light has long been considered impossible due to their photo-lability, which actually m
82 rity of cells, however, remains difficult or impossible due to their small size and/or sensitivity to
83 evices), but this is rapidly becoming almost impossible, due to physical and lithographic limitations
84 rol of an animal's environment and otherwise impossible experimental manipulations.
85 P. ramorum is now not possible, and has been impossible for a number of years.
86 he intermediate state or making it virtually impossible for an opposition to form.
87 hese orbits have anomalous features that are impossible for conventional surface states, and result i
88 velop along myeloid lineage, whereas this is impossible for later developmental stages.
89                          Recommendations are impossible for mycophenolate, montelukast, intravenous i
90  partial success, communication has remained impossible for persons suffering from complete motor par
91  aquaculture ponds have made it difficult or impossible for previous video cameras to provide clear i
92 olloids in water, however, has made PB to be impossible for the open-field radioactive cesium deconta
93 ontradict each other, making it difficult or impossible for the practitioner to draw any meaningful c
94 plification as in classical communication is impossible for unknown quantum states.
95  other tasks, such as nest repair, it may be impossible for workers not directly at the work site to
96                                       It was impossible, however, to determine precisely which factor
97                           However it remains impossible identify the adulterations made with the sacc
98                       Moreover, the task was impossible if the source trajectories did not maintain s
99  a support to hold up objects looked more at impossible images with string hanging from below (unsupp
100 to determine nutritional exposures are often impossible, impractical, or unaffordable.
101                       Dental examination was impossible in 29 patient because of trismus.
102                     This has been previously impossible in animal and human research.
103 xtremely challenging experimentally and even impossible in clinical applications.
104  it sets the boundaries between possible and impossible in macroscopic aggregates of matter.
105 arker miRNAs with the naked eye is seemingly impossible in molecular diagnostics.
106 ng this process in vivo is difficult or even impossible in most vertebrates.
107 estimation of the target content in feeds is impossible in practice.
108 e.g. a communications channel on which it is impossible in principle to eavesdrop without a high prob
109 ce for ventricular arrhythmias is limited or impossible in some cases.
110 connectivity pattern, which is thought to be impossible in the brain.
111 ution DNP methods has facilitated previously impossible in vitro and in vivo study of small molecules
112 t-after model substrates enabling previously impossible investigations of poorly understood protein t
113 the complete elimination of uncertainties is impossible, LCA results should be complemented by an unc
114 h-quality assembly from Illumina reads alone impossible (N50=222 bp).
115 eo games - tasks that would have been deemed impossible not too long ago.
116 t can result in selective processes that are impossible or difficult to achieve by traditional method
117 roducing bulk materials when melt casting is impossible or does not achieve a desired microstructure,
118 s is a labor-intensive process that is often impossible or unfeasible.
119 cation to these changes is difficult, if not impossible, owing to the confounding effects of other en
120 eneous flow near lower temperatures which is impossible previously.
121              This allows the observation of 'impossible' properties of light and of a fundamental fie
122 particle samples, avoiding tedious and often impossible purification and fractionation of nanoparticl
123 nd systematic testing of all combinations is impossible, so robust methods to predict the effects of
124  to produce all drones prior to swarming, an impossible solution on a population scale because queens
125 d or in ionic liquids where chemisorption is impossible (such as [P66614][NTf2]) undergoes reduction
126 to run, and drug development would be a near impossible task.
127 ular dynamics trajectories is still a nearly impossible task.
128  directionality can drive chemical reactions impossible through conventional means.
129                                        It is impossible to 'clone' species for which no living cells
130                         In particular, it is impossible to a priori balance the trade-off between the
131 cyclooctatetraenyl radicals, which have been impossible to access through classical synthetic methods
132 compounds that would be difficult or perhaps impossible to access using other methods.
133 ctionally diverse arylated products that are impossible to access using separate enzymatic or chemoca
134 hitectures that were previously difficult or impossible to access.
135 oss multiple years of sampling, it is nearly impossible to accurately detect any directional shift in
136  favored by natural selection are apparently impossible to achieve developmentally.
137 n a material that would be difficult or even impossible to achieve in the bulk state.
138         A low expired tidal volume is almost impossible to achieve in the majority of patients receiv
139                          In 11 cases, it was impossible to achieve sustain entrainment.
140 nvasive operation that would be difficult or impossible to achieve using conventional approaches.
141 f analysis (cell damage) is difficult if not impossible to achieve using traditional plate counting m
142  enabling access to sample sections that are impossible to achieve with conventional sample preparati
143 d processed in fascinating new ways that are impossible to achieve with natural materials and in conv
144 ir repair in vivo-something otherwise nearly impossible to achieve.
145  can address questions that are difficult or impossible to answer by other means, yet the complexity
146  many questions in genetics are difficult or impossible to answer.
147 e to soft tissues are generally difficult or impossible to apply to the skeleton.
148 er larger number of stationary phases, it is impossible to arrive at a single successful approach.
149 ft similar material cultural remains, it was impossible to attribute any open-air site to either spec
150 eic acids that is otherwise difficult if not impossible to be quantified by the ZZ-exchange NMR exper
151 In practice, however, it can be difficult or impossible to blind study participants and unblinded tri
152 mation about processes in the cell that were impossible to characterize with existing techniques in s
153                  Established infection seems impossible to clear.
154 nd unpredictable structure that is presently impossible to clone.
155  changes when root growth stops, it has been impossible to compare cellular dynamics as stem cells tr
156 breast cancer make them impractical and even impossible to conduct.
157            Leibovich et al. argue that it is impossible to control for all continuous magnitudes in a
158          This degree of instability makes it impossible to correlate the structure of AuNPs determine
159 s slow, and many pathogens are fastidious or impossible to cultivate.
160 ir of infected cells that has made it almost impossible to cure HIV-infected patients.
161 n development and disease, one that has been impossible to date.
162    Finally, we argue that the loners make it impossible to define altruistic behavior, winners or los
163 er is vital to public health; however, it is impossible to deliver sterile drinking water to consumer
164 good visibility, ash clouds are difficult or impossible to detect by eye.
165 is key and surprising result would have been impossible to detect if only one population was mapped.
166 fer FAPA conditions, which were difficult or impossible to detect with proton-transfer FAPA or direct
167 for comparing alternative scenarios makes it impossible to determine if observed faunal differences v
168 itative peripheral nerve stimulator makes it impossible to determine the actual train-of-four ratio.
169                      Thus, it was previously impossible to determine the NK cell-intrinsic role of SH
170         The lack of subtyping tools makes it impossible to determine the role of zoonotic transmissio
171 gnaling; however, the loss of cilia makes it impossible to determine whether hair follicle phenotypes
172        The dual topology of MRAP has made it impossible to determine whether highly conserved and nec
173 f implementation and context of use makes it impossible to determine why some health IT implementatio
174 ferent experimental conditions, rendering it impossible to directly compare their activity.
175 de (NO2) in the presence of ozone, making it impossible to directly measure (15)N in NO.
176 Cs in human biology and disease, it has been impossible to directly monitor the real-time activation
177 tractants remain unclear, as it is currently impossible to directly observe and accurately measure th
178 e micrometer length scale, it was previously impossible to directly observe obliteration processes on
179                        Nowadays, it is still impossible to directly show the difference between exter
180  so many interesting papers presented, it is impossible to discuss everything, but some key areas are
181 tial equation, and that it is mathematically impossible to do this using inclusive fitness.
182 trial, where methodological problems make it impossible to draw any conclusion about efficacy.
183 onditions are altered, making it essentially impossible to draw conclusions when comparing the outcom
184                                  While it is impossible to eliminate a mutation bias of unknown cause
185                           Although it may be impossible to eliminate all ethical dilemmas and conflic
186 most importantly, it is difficult and may be impossible to eliminate eukaryocentric bias from the mea
187 ing in a recurrent phenotype that makes them impossible to eradicate in the long term.
188 read parameters are estimated exactly, it is impossible to estimate the probability of a major outbre
189 is plagued by imprecision, making it largely impossible to evaluate the authors' theory in a scientif
190 emical and structural data that was hitherto impossible to evaluate.
191 astic in Df(16)A(+/-) mice, making it nearly impossible to evoke action potential firing in CA2 pyram
192  the earlier extinction is identified, it is impossible to exclude the possibility that this pattern
193 tor and its signaling are deleted, making it impossible to explore the possible signaling-independent
194                    In situations where it is impossible to find appropriate matches for all exposed s
195 te the impact of space weather because it is impossible to forecast the solar eruptions that can caus
196 These results suggest that in general, it is impossible to form flat two-dimensional nanocrystalline
197                           In contrast, it is impossible to identify deleterious mutations using most
198  at a rapid rate, and orthologues are nearly impossible to identify in different vertebrate classes.
199 ty of protein structures, it is often almost impossible to identify independent subunits, flexible re
200 icular brain area or cell type, rendering it impossible to identify neuronal ensembles critically inv
201 yletic within the species complex, making it impossible to identify them on the basis of conserved ge
202 anti-Stokes emission can be >10, while it is impossible to image the particles with the Stokes emissi
203                              Nowadays, it is impossible to imagine modern cancer treatment without ta
204 transformations that would be challenging or impossible to implement using saturated nitrogen heteroc
205 , in animals and seed plants it is virtually impossible to investigate the effects of specific gamete
206 erical shapes and sizes of 1-5 nm, making it impossible to investigate their facet-dependent catalyti
207    Leibovich et al. argue that because it is impossible to isolate numerosity in a stimulus set, atte
208 his regime are so nonlinear that it is often impossible to know the fraction of absorbed light f, and
209            Without a comparison group, it is impossible to know whether any improvement observed afte
210 xpansion, regardless of subset origin, it is impossible to know which subsets contribute to the final
211                                  While it is impossible to know with certainty the subjective experie
212 uting environment, which may be difficult or impossible to match using written instructions.
213 ate complex parameters that are difficult or impossible to measure otherwise, such as water toxicity
214                              Although it was impossible to meet the predefined study outcomes, we ana
215 taclusters in solution that are difficult or impossible to observe by traditional solution techniques
216 time scales that often are very difficult or impossible to obtain from experiments alone.
217 large gene segments that may be difficult or impossible to obtain from formalin-fixed tissues.
218 nsights that would otherwise be difficult or impossible to obtain with macroscopic cell culture in tr
219 collection efficiencies of 100% are probably impossible to obtain with this system geometry.
220 structures that previously were difficult or impossible to obtain.
221 verage COI is high, they can be difficult or impossible to obtain.
222 owever, studies on cell/matrix interplay are impossible to perform due to disruptions in cell viabili
223  human, where such analyses are difficult or impossible to perform.
224 roups exhibiting the same reactivity make it impossible to precisely control the number and the posit
225 ther find that high-order epistasis makes it impossible to predict evolutionary trajectories from the
226 ng extracellular matrix in culture is almost impossible to predict or experimentally control.
227 2 shedding patterns within an individual are impossible to predict over weeks or months, and that eve
228                               As such, it is impossible to predict the exact quantity of a molecule o
229 o devastating pandemics, but currently it is impossible to predict the pandemic potential of circulat
230                             Currently, it is impossible to predict therapeutic response.
231                            It is essentially impossible to predict whether an LO project might ultima
232              At the time of diagnosis, it is impossible to predict which patients develop severe dise
233                                 It is nearly impossible to predict which strains will be circulating
234 h eyes following bilateral NAION it is still impossible to predict with certainty the visual outcome
235 ials that, at present, are difficult or even impossible to prepare using traditional synthetic approa
236                    As human RAD51 has proved impossible to produce in a form that is compatible with
237               We explain why it is virtually impossible to propagate a tear in rabbit skin, chosen as
238                                     Although impossible to prove causality with any single approach,
239 ar function, especially for regions that are impossible to purify and are therefore inaccessible to t
240                        However, it is almost impossible to rapidly identify adult fragments and non-a
241  and sedimentation techniques that are often impossible to rationalize and control to give a desired
242                                        It is impossible to read and summarize these references manual
243 s, there exist gene tree topologies that are impossible to reconcile with any species tree.
244         Using these transcripts, we found it impossible to reliably identify true DCCs.
245 ous model building and validation, which are impossible to replicate in most complex biological, soci
246 molecular constructs that would otherwise be impossible to replicate with the separate components.
247   By means of a regular MRCP protocol it was impossible to reveal any disorders of the biliary system
248  protected in such a way that it is close to impossible to reverse engineer, as well as being easy to
249 of common problems that make it difficult or impossible to run outside the original institution or ev
250 for these decoders are such that it has been impossible to scale them to naturalistic settings.
251                                  However, if impossible to scale up existing interventions to the ext
252  the intermediate and deep layers, a feature impossible to see with only iron concentration data larg
253 the effects of these climatic variables were impossible to separate; however, they may play key roles
254 y to investigate aspects of disease that are impossible to study in patients or animal models.
255 transcribed in polycistrones, yet it remains impossible to study nascent mtDNA transcripts quantitati
256 es and continuous magnitudes makes it nearly impossible to study non-symbolic numerosity processing i
257 , and spontaneous onset have made it nigh on impossible to study somnambulism behaviorally during wak
258  insight into problems that are difficult or impossible to study with classical computers.
259 son, who is at no risk of harm, will make it impossible to sustain prohibitions on paying living dono
260 n complex turbulent dynamical systems, it is impossible to track and control the large dimension of i
261 r, are difficult to ionize by LDI, making it impossible to track these NPs in biological samples.
262 ma of distant organs--it is difficult if not impossible to translate such knowledge into medicine due
263  bloodstream infections that are effectively impossible to treat in this resource-limited setting.
264 rimental drug, using a randomization process impossible to understand by very sick patients.
265  West syndrome or hydrocephalus, it might be impossible to unravel whether CVI is caused by the seizu
266                 Furthermore, it is currently impossible to use mechanosensor activity to drive gene e
267 range of biological effects, but practically impossible to visualize in single cells.
268 olyelectrolytes, which were hitherto deemed "impossible" to process, since they are infusible and bri
269 itical ideologies that are difficult (if not impossible) to explain in terms of stable, negative affe
270 s many attributes that are difficult, if not impossible, to achieve with conventional robots composed
271 vast majority of which are difficult, if not impossible, to cultivate with current approaches.
272 time being recognized as challenging, if not impossible, to define.
273  more complex mechanism is difficult, if not impossible, to distinguish experimentally from simple fi
274 ermore, it is often difficult, and sometimes impossible, to incorporate environmental perturbation fo
275 , suggesting they would be difficult, if not impossible, to isolate under conventional high-temperatu
276 erimental protocols, it is difficult, if not impossible, to make meaningful comparisons between diffe
277  importantly because it is difficult, if not impossible, to prove that a given marker exhaustively an
278 to be significantly more challenging, if not impossible, to separate by conventional drift tube techn
279 rials that would have been difficult-or even impossible-to obtain using traditional hydrothermal tech
280  structural plasticity allow them to perform impossible tricks and be engaged in biological activitie
281  very different factors, hence a modeling is impossible unless more precise knowledge regarding the i
282 dividual muscle fibers, which was previously impossible using any laboratory-based imaging technique.
283 pression and targeting of the host is almost impossible using conventional Cre-loxP-based models.
284 , as a consequence of instability, it can be impossible-using traditional methods-to concentrate cert
285 sured looking time responses to possible and impossible video and image stimuli.
286  peptides on the basis of methylation-a feat impossible with a comparable commercial cation-exchange
287 nanoscale Schottky barrier, in a way that is impossible with conventional optoelectronic materials.
288 tor, enables time-course mechanistic studies impossible with current wounding methods.
289             We prove that strong-coupling is impossible with monolayers due to the large exciton cohe
290 avepackets, and manipulated in ways that are impossible with purely electromagnetic signals, due to t
291 to develop light-based technologies that are impossible with traditional optics.
292 shing between these kinds of niche shifts is impossible with traditional, correlative approaches to i
293 dy of the link between brain and behavior is impossible without a guiding vision.
294            Importantly, this would have been impossible without interfacial stratification of plasma
295 es a rigorous comparison across size classes impossible without long-term demographic data.
296           Achieving this goal is essentially impossible without mathematical models, which provide a
297 ngs of different particle types is virtually impossible without the availability of a sound model to
298 idea is that substantial gene additions were impossible without the energetic boost provided by the c
299                     The process of vision is impossible without the photoreceptor cells, which have a
300 t that many CT diagnostic decisions would be impossible without the use of iodine, this study suggest

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