ライフサイエンスコーパス: imprinted gene

1 with the mode of inheritance expected for an imprinted gene.

2 ethylation and allele-specific expression of imprinted genes.

3 icroRNAs, including neighboring reciprocally imprinted genes.

4 mplex nature and developmental importance of imprinted genes.

5 ription is under the control of the extended imprinted genes.

6 negatively associated with the expression of imprinted genes.

7 search has not demonstrated paternal bias in imprinted genes.

8 ut overall up-regulation in the other nearby imprinted genes.

9 xpression of paternal or maternal alleles of imprinted genes.

10 rome, both of which involve dysregulation of imprinted genes.

11 oup of hypomethylated genes was enriched for imprinted genes.

12 Both BWS and LOS involve misregulation of imprinted genes.

13 dence supports perhaps 100 additional weakly imprinted genes.

14 se dispositions may be subject to effects of imprinted genes.

15 and intersected them with the list of human imprinted genes.

16 evels agreed well with methylation levels at imprinted genes.

17 nes, including zinc finger protein (ZFP) and imprinted genes.

18 pigenetic features within or in proximity to imprinted genes.

19 m DNA methylation in, or near, 19 of the 100 imprinted genes.

20 chromosome 7 (dist7), a region replete with imprinted genes.

21 eggs displaying normal epigenetic changes of imprinted genes.

22 constitute a layer of the "histone code" at imprinted genes.

23 e for additional undefined misexpressions of imprinted genes.

24 ipheral blood leukocytes at DMRs of 22 human imprinted genes.

25 creased mRNA expression of the corresponding imprinted genes.

26 rations in DNA methylation and expression at imprinted genes.

27 cluding 41 novel and independently validated imprinted genes.

28 spectrum disorder (ASD) candidate genes, and imprinted genes.

29 ously identified temporally activated and/or imprinted genes.

30 d for parental origin-specific expression of imprinted genes.

31 rier is mediated by suppressed expression of imprinted genes.

32 an individual is not sufficient to identify imprinted genes.

33 Thus Grb10 is, so far, a unique imprinted gene, able to influence distinct physiological

34 er, mono-allelically expressed genes such as imprinted genes, allelically excluded genes and genes on

35 Here we show that the majority of A. lyrata imprinted genes also exhibit parentally biased expressio

36 More recently, it has become evident that imprinted genes also have important roles after birth.

37 14 d after pollination was used to identify imprinted genes among a set of ~12,000 genes that were e

38 on the differentially methylated regions of imprinted genes, an additional fine tuning of the expres

39 normal epigenetic reprogramming of the three imprinted genes analyzed.

40 tion of imprinting control regions of select imprinted genes and a global reduction in DNA methylatio

41 With the exception of imprinted genes and certain repeats, DNA methylation is

42 , we not only show that misregulation of non-imprinted genes and loss-of-imprinting characterize the

43 These imprinted genes and mechanisms could be used to improve

44 of both maternally and paternally expressed imprinted genes and microRNAs, including neighboring rec

45 t a major decrease in expression of multiple imprinted genes and microRNAs, which is partially mimick

46 dentified signals that control expression of imprinted genes and miRNAs through transcriptional mecha

47 Among the dysregulated genes were imprinted genes and non-coding RNAs including Dlk1 and M

48 ing similar mechanisms for the regulation of imprinted genes and non-coding RNAs.

49 methylomes are tightly connected with known imprinted genes and precisely delineate the boundaries o

50 methylated regions for the identification of imprinted genes and suggest that parent-of-origin depend

51 ocal allele-specific features are limited to imprinted genes and their differentially methylated regi

52 Epigenetic regulation of imprinted genes and transposable elements has been impli

53 ASM has long been studied as a hallmark of imprinted genes, and a chromosome-wide version of this p

54 egulatory networks of transcription factors, imprinted genes, and loci marked with histone H3 trimeth

55 pomethylation, which is reversible except at imprinted genes, and that the X chromosome status resemb

56 e loci, including the inactive X chromosome, imprinted genes, and the facioscapulohumeral muscular dy

57 Many imprinted genes appear to be highly interconnected throu

58 However, several growth-associated imprinted genes are also expressed in the embryonic CNS,

59 Imprinted genes are commonly expressed in mammalian plac

60 the current study, we sought to test whether imprinted genes are differentially expressed between the

61 Imprinted genes are dosage sensitive, and their dysregul

62 hat the expression levels of the majority of imprinted genes are downregulated in primary tumors comp

63 Maternally expressed imprinted genes are enriched for hypomethylation at puta

64 ing pre-natal nutrition and growth, and most imprinted genes are expressed and imprinted in the place

65 als, one of the female X chromosomes and all imprinted genes are expressed exclusively from a single

66 Imprinted genes are expressed in a monoallelic, parent-o

67 Many imprinted genes are expressed in neural systems associat

68 Imprinted genes are expressed primarily or exclusively f

69 s the evolutionary fluidity with which novel imprinted genes are gained and lost within genomes.

70 As such, many imprinted genes are highly expressed in sex-specific rep

71 However, many LTR retrotransposons and imprinted genes are impervious to such global epigenetic

72 ve speculation, but no robust evidence, that imprinted genes are involved in preeclampsia.

73 these striking phenotypes, only a handful of imprinted genes are known or suspected to regulate brain

74 Imprinted genes are monoallelically expressed according

75 Effects of imprinted genes are not predicted in interactions with n

76 Clusters of imprinted genes are often controlled by an imprinting ce

77 Many imprinted genes are often epigenetically affected in hum

78 Clusters of imprinted genes are regulated by imprinting control regi

79 Overall, the results indicate that several imprinted genes are sexually different in terms of their

80 The expression levels of these imprinted genes are usually greater in males than in fem

81 ce with a knockout of a maternally expressed imprinted gene, Ascl2 [achaete-scute complex homolog-lik

82 intracellular signaling, ion transport, and imprinted genes associated with various neurodevelopment

83 The monoallelic expression of imprinted genes at these three loci was maintained.

84 to wipe out remaining methylation, including imprinted genes, at the late reprogramming stage.

85 Our analysis did not reveal any novel imprinted genes, but detected extended parental allele-s

86 features have been used to predict candidate imprinted genes, but rigorous testing using reciprocal c

87 The epigenetic regulation of imprinted genes by monoallelic DNA methylation of either

88 ndance of genomic data has demonstrated that imprinted genes can be important contributors to complex

89 encing, identified missense mutations in the imprinted gene CDKN1C (also known as P57KIP2) in two fam

90 ts show that proper expression levels of the imprinted genes CDKN1C and PHLDA2 are critical for embry

91 lly inherited microduplications spanning the imprinted genes CDKN1C, PHLDA2, SLC22A18 and KCNQ1, sugg

92 These results demonstrate a link between an imprinted gene cluster and malignancy, reveal a new path

93 paternally derived gene expression from the imprinted gene cluster on human chromosome 15q11-q13.

94 Thus, the expression state of a single imprinted gene cluster seems to distinguish most murine

95 Imprinted gene clusters are regulated by long noncoding

96 histone H3K4me3 and H3K9me3 modifications at imprinted gene clusters, and identifies common epigeneti

97 extent of domain-wide epigenetic features at imprinted gene clusters, we performed a high-resolution

98 d monoallelic expression to several genes in imprinted gene clusters.

99 xpression and DNA methylation at established imprinted gene clusters.

100 If true, epigenetically regulated imprinted genes, critical to normal growth and developme

101 Imprinted genes, defined by their preferential expressio

102 For the first time, an imprinted gene directly involved in this process has bee

103 In mammals, imprinted genes directly regulate placental function and

104 Thirty-two known ubiquitously imprinted genes displayed correct parental allele-specif

105 The 78 candidate imprinted genes displayed parent-of-origin expression bi

106 and cohesin with silencing of H19 and other imprinted genes during critical stages of postnatal brai

107 on is maintained at LTR retrotransposons and imprinted genes during developmental stages when DNA met

108 rice endosperm and functional tests of five imprinted genes during seed development using Clustered

109 ittle is known about the functions of bovine imprinted genes during the pre-implantation period.

110 riptome organization, and obesity-associated imprinted gene dysregulation.

111 DIRAS3 (also known as ARH1 or NOEY1) is an imprinted gene encoding a protein belonging to the RAS s

112 onstrate that the human H19 locus harbors an imprinted gene encoding a tumor suppressor protein withi

113 duces paternally expressed gene 3 (Peg3), an imprinted gene encoding a zinc finger transcription fact

114 ce with differing allelic dosage of Igf2, an imprinted gene encoding the potent embryonic and tumour

115 ng the germline epigenetic erasure including imprinted genes, epimutations, and erasure-resistant loc

116 e level similar to maternal chromatin, while imprinted genes exhibit allelic accessibility bias.

117 the possibility that intriguing networks of imprinted genes exist and are important for genetic and

118 f the maternally inherited copy of UBE3A, an imprinted gene expressed biallelically in most tissues,

119 Overlaps between imprinted sRNA loci and imprinted genes expressed from opposite alleles suggest

120 cent studies that have identified changes in imprinted gene expression and erosion of X chromosome in

121 versity within a species can readily perturb imprinted gene expression and phenotype as well.

122 Imprinted gene expression associated with Prader-Willi s

123 DNA methylation mediates imprinted gene expression by passing an epigenomic state

124 Imprinted gene expression corresponds to parental allele

125 Flowering plant imprinted gene expression has been described primarily i

126 Here we review imprinted gene expression in intra- and interspecies hyb

127 The regulation of imprinted gene expression in this region is coordinated

128 Our results show that imprinted gene expression is an extensive mechanisticall

129 Imprinted gene expression is one consequence of a large-

130 Imprinted gene expression occurs during seed development

131 In plants, imprinted gene expression occurs in endosperm seed tissu

132 -IC) within 15q11.2-13.3 disrupts long-range imprinted gene expression resulting in Prader-Willi synd

133 ails about the regulation of dosage-critical imprinted gene expression through the regulated binding

134 Imprinted gene expression--the biased expression of alle

135 ediated genetic and epigenetic regulation of imprinted gene expression.

136 nderstand the effect of natural selection on imprinted gene expression.

137 epigenetic modification systems that control imprinted gene expression.

138 hylation mediates parent-of-origin-specific (imprinted) gene expression but is apparently unnecessary

139 We identify a novel imprinted gene, Fkbp6, which has a critical function in

140 , I bring together studies of the effects of imprinted genes from the prenatal period onwards.

141 developmental brain functions influenced by imprinted genes, from neural development and wiring to s

142 icle, the growth effects associated with the imprinted gene Grb10 are consistent with this idea, but

143 Using the mouse as a model, we identify the imprinted gene Grb10 as a mediator of nutrient supply an

144 S OBs exhibited impaired upregulation of the imprinted gene H19 during osteogenesis.

145 egions) controlling two paternally repressed imprinted genes, H19 and Gtl2, can efficiently support t

146 Like most imprinted genes, H19 and Igf2 are regulated by a differe

147 Expression of coregulated imprinted genes, H19 and Igf2, is monoallelic and parent

148 ion the parental allele specificity of known imprinted genes, H19, Igf2, Igf2as, Cdkn1c, Kcnq1ot1, an

149 ific DNA methylation and expression at three imprinted genes, H19, Snrpn, and Peg3, in somatic cells

150 Our data suggest that most of the strongly imprinted genes have already been identified, at least i

151 Although many imprinted genes have been identified in plants, the func

152 While many imprinted genes have been identified in plants, the func

153 Imprinted genes have been identified in several animal s

154 Imprinted genes have been implicated in early embryonic,

155 Similarly, an increasing number of imprinted genes have been implicated in regulating feedi

156 they might represent a pool from which many imprinted genes have evolved.

157 It has long been established that imprinted genes have major effects on development and pl

158 rors are minimized by the tight control that imprinted genes have on regulation of downstream evoluti

159 identified in plants, the functions of these imprinted genes have remained largely uninvestigated.

160 An additional 78 candidate imprinted genes identified by RNA sequencing also showed

161 The imprinted maize genes were compared with imprinted genes identified in genome-wide screens of ric

162 The imprinted genes IGF2 and IGF2R code for the growth promo

163 ferase Dnmt3a2, causing misexpression of the imprinted genes Igf2, H19, and Igf2r and hypomethylation

164 isrupts the normal expression profile of the imprinted genes IGF2-H19 and also results in a loss of i

165 otein kinase), and several growth regulatory imprinted genes (Igf2, Dlk1, Snrpn, Grb10, and H19) inde

166 tially expressed genes (DEGs), including the imprinted gene IGF2R, could be associated with the neigh

167 iding strong evidence that Ascl2 is the only imprinted gene in the genome for which PatDp results in

168 gen 6 complex, locus G6C, a newly identified imprinted gene in the major histocompatibility complex.

169 This suggests that the number of imprinted genes in a typical mouse somatic tissue is rel

170 rnally expressed and 34 maternally expressed imprinted genes in A. thaliana endosperm that are regula

171 ry, we characterized previously unidentified imprinted genes in bovines and identified misregulation

172 a solid reference for expression profiles of imprinted genes in embryos produced using assisted repro

173 Given the role of imprinted genes in human placentation and the vulnerabil

174 importance of proper expression of specific imprinted genes in induced pluripotent stem cells and in

175 ht and the number of biallelically expressed imprinted genes in LOS fetuses.

176 Biallelic expression of imprinted genes in LOS was associated with tissue-specif

177 there loss of allele-specific expression of imprinted genes in LOS, but also differential transcript

178 sulted in the identification of 100 putative imprinted genes in maize endosperm, including 54 materna

179 characterized the epigenetic instability of imprinted genes in multiple human cancers.

180 ypomethylation and enriched dysregulation of imprinted genes in Naa10p-knockout embryos and embryonic

181 e for CTCF and cohesins in the repression of imprinted genes in somatic cells.

182 ut mice revealed hypermethylation of DMRs of imprinted genes in sperm, which can be traced back to PG

183 rk has also demonstrated intricate roles for imprinted genes in the brain, with important consequence

184 t1 mutations on the expression of a panel of imprinted genes in the embryo and placenta.

185 We did not detect any imprinted genes in the embryo.

186 igin effects, suggesting a possible role for imprinted genes in the evolution of Mimulus hybrid seed

187 The number of imprinted genes in the mammalian genome is predicted to

188 RNA-seq reveals extensive dysregulation of imprinted genes in the next generation due to paternal l

189 confirmed the imprinting status of 23 known imprinted genes in the placenta and found that 12 genes

190 thylation and silencing at a cluster of four imprinted genes in the Prader-Willi syndrome (PWS) locus

191 methylated regions in order to identify new imprinted genes in their vicinity.

192 lencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in

193 This pattern is also evident for imprinted genes, in which more chromatin contacts are de

194 One development is regarding analyses of imprinted genes, in which recent work suggests the possi

195 e to provide a high confidence list of mouse imprinted genes including 18 novel genes.

196 e we show upregulation of growth-restricting imprinted genes, including in the H19-Igf2 locus, in lon

197 Monoallelic expression of imprinted genes, including ones solely expressed in the

198 This disomic region contains imprinted genes, including the gene encoding the cell cy

199 Recent work on postnatal stages shows that imprinted genes influence an extraordinarily wide-rangin

200 Imprinted genes influence processes including developmen

201 levels have been reported as well, including imprinted genes involved in development and growth.

202 ) that control the monoallelic expression of imprinted genes involved in metabolism, growth, and deve

203 d to compare the methylation levels of seven imprinted genes involved in prenatal and postnatal growt

204 The PEG3 protein encoded by this imprinted gene is predicted to bind DNA based on its mul

205 inted expression of the linked, reciprocally imprinted genes is explained by parent-of-origin-specifi

206 ignificance statement: Altered expression of imprinted genes is linked to cognitive dysfunction and n

207 Thus, the sexual bias observed in the imprinted genes is most likely attributable by gonadal h

208 Parent-of-origin-specific expression at imprinted genes is regulated by allele-specific DNA meth

209 deduce that the importance of the number of imprinted genes is secondary to their interactions.

210 The most direct way to identify imprinted genes is to directly score the DAE in a contex

211 , a developmentally regulated and maternally imprinted gene, is frequently overexpressed in pediatric

212 Dlk1, a member of a cluster of imprinted genes, is expressed from the paternally inheri

213 rm, rather than loss of paternally expressed imprinted genes, is the primary cause of embryonic letha

214 y, iPS cells exhibited aberrant silencing of imprinted genes known to participate in endoderm differe

215 ed in the complete loss of expression of the imprinted genes L3MBTL1 and SGK2, indicative of a pathog

216 Peg3 (paternally expressed gene 3) is an imprinted gene localized within an evolutionarily conser

217 Maternally expressed gene 3 (MEG3) is an imprinted gene located at 14q32 that encodes a lncRNA, a

218 Maternally expressed gene 3 (MEG3) is an imprinted gene located at 14q32 which encodes a noncodin

219 MKRN3 is a paternally expressed, imprinted gene located in the Prader-Willi syndrome crit

220 Expression levels of 18 imprinted genes (MAGEL2, UBE3A, IGF2R, NAP1L5, TSSC4, PE

221 lenged the interpretation of a study into an imprinted gene, maintaining that conflict, rather than m

222 that the transcriptional regulation of these imprinted genes may be influenced by unknown mechanisms

223 al and/or variance in reproductive success), imprinted genes may evolve to modulate social behaviour,

224 Leukocyte DNA methylation levels of selected imprinted genes may therefore serve as surrogate markers

225 We also show that several imprinted genes (Mest, Peg3, Snrpn and Meg3) are aberran

226 tion influences offspring repeat element and imprinted gene methylation.

227 Rare variants near the imprinted genes MKRN3 and DLK1 were identified, exhibiti

228 By integrating human imprinted gene network (IGN) into functional genomic ana

229 s the expression of several genes within the Imprinted Gene Network (IGN), involved in growth control

230 Loss of ATRX prevents full repression of an imprinted gene network in the postnatal brain and in thi

231 is characterized by reduced expression of an imprinted gene network including Nnat, Peg3, Cdkn1c, and

232 stem cells for another member of a putative imprinted gene network that may influence organismal gro

233 ortant implications for the understanding of imprinted gene networks.

234 Imprinted genes occur in discrete clusters that are coor

235 ch, we identified a core group of 15 ancient imprinted genes, of which 10 were paternally expressed.

236 ssess the influence of altered expression of imprinted genes on developmental progress of embryos usi

237 s-homologue interaction between reciprocally imprinted genes on the maternally and paternally inherit

238 ne ontology analysis showed an enrichment of imprinted genes (P = 9.53 x 10(-10)) and genes previousl

239 lation status within 3 maternally methylated imprinted genes: paternally expressed gene 3 (PEG3), ins

240 The imprinted gene PEG3 confers parenting and sexual behavio

241 zed within the 3'-untranslated region of the imprinted gene, Peg3.

242 We measured methylation of LINE1 and the imprinted genes, PEG3, SNRPN, and IGF2, in cord blood.

243 nctional requirement of paternally expressed imprinted genes (PEGs) during seed development in Arabid

244 eatures associated with paternally expressed imprinted genes (PEGs).

245 he underlying mechanisms, the full extent of imprinted gene perturbation still remains to be determin

246 ns of selection, suggesting that a subset of imprinted genes play an important functional role and ar

247 Additionally, we derived an imprinted gene predictor algorithm based on our allele-s

248 s include all paternally expressed autosomal imprinted genes previously demonstrated to be independen

249 we determined allele-specific expression of imprinted genes previously identified in human and/or mo

250 c methylation (RGM) that relies on a minimal imprinted gene promoter driving a fluorescent protein.

251 syndrome (AS/PWS) domain contains at least 8 imprinted genes regulated by a bipartite imprinting cent

252 rly human development and DNA methylation of imprinted gene regulatory elements in adulthood.

253 ites, intracisternal A particles (IAPs), and imprinted genes remain relatively resistant to erasure.

254 nscriptome-wide evaluations of the number of imprinted genes reveal complex patterns of imprinted exp

255 Over 10% of imprinted genes show evidence of allelic variation for i

256 sue DNA methylation for most of the analyzed imprinted genes, Spearman's correlations were statistica

257 Dysregulation of imprinted genes, such as those within the Dlk1-Dio3 locu

258 Gene ontology enrichment analysis of the imprinted genes suggested that 10-DAP endosperm-specific

259 mous substitution ratios compared with other imprinted genes, suggesting a history of more rapid evol

260 idgestation, with loss of DNA methylation on imprinted genes, suggesting that DMAP1 influences mainte

261 esin with the control regions of a subset of imprinted genes, supporting the notion that imprinting c

262 ing genes and therefore may help explain why imprinted genes tend to be found in clusters.

263 Our results showed that LRE is a rare imprinted gene that functions immediately after double f

264 0) is a signal adapter protein encoded by an imprinted gene that has roles in growth control, cellula

265 Grb10 is, therefore, the first example of an imprinted gene that regulates social behaviour.

266 e in mammals, Meg1 is a maternally expressed imprinted gene that surprisingly acts to promote rather

267 expression among the tissues and most of the imprinted genes that are expressed solely from the pater

268 ifications deposited at different alleles of imprinted genes that are required for genomic imprinting

269 he expression of a network of epigenetically imprinted genes that have been implicated in cell growth

270 al aspects of a scheme for identification of imprinted genes that makes use of RNA sequencing (RNA-se

271 H19 and Igf2 are linked imprinted genes that play critical roles in development.

272 llele-specific expression, we found 10 novel imprinted genes that were maternally expressed in the pl

273 c-expression technology, we verified 5 novel imprinted genes that were not previously known to be imp

274 onsistent with known misexpressions of dist7 imprinted genes, the overall phenotype indicates a role

275 eri-implantation due to the misexpression of imprinted genes-the genes that are expressed monoallelic

276 Imprinted genes themselves have undergone purifying sele

277 he addition of our validated set of placenta-imprinted genes, this maternal bias has disappeared.

278 an development, and this is primarily due to imprinted genes, those that are monoallelically expresse

279 om mother to fetus; however, none of the >60 imprinted genes thus far reported in plants have been de

280 human placentation and the vulnerability of imprinted genes to loss of imprinting changes, there has

281 oss of neuronal expression of the paternally imprinted gene Ube3a in Angelman syndrome results in sel

282 It is caused by maternal deficiency of the imprinted gene UBE3A, encoding an E3 ubiquitin ligase.

283 ency of genes, failure to express parentally imprinted genes, uncovering of X chromosome mutations, a

284 assessment of histone lysine acetylation at imprinted genes we measured allele-specific acetylation

285 gnature of MEFs and potentially detect novel imprinted genes we performed strand- and allele-specific

286 As a first-pass scan for novel imprinted genes, we performed mRNA-seq experiments on em

287 evolutionary signature of parental conflict, imprinted genes were enriched for coexpressed pairs of m

288 Nearly all imprinted genes were imprinted in early development and

289 In the hypothalamus, sex-specific imprinted genes were mostly found in females, which sugg

290 Imprinted genes were overrepresented among genes that we

291 The majority of imprinted genes were parentally biased in the same manne

292 Twenty-six imprinted genes were quantified in bovine in vivo produc

293 Imprinted genes were recently shown to be expressed in m

294 Specifically, we targeted imprinted genes, which play important roles in allocatio

295 Here we show that only 5% of known imprinted genes with paternal allele silencing are monoa

296 Many of the imprinted genes with reduced DNA methylation levels also

297 to display an excess of maternally expressed imprinted genes, with the addition of our validated set

298 tal 5-methylcytosine content and reactivates imprinted genes (without causing myeloid differentiation

299 Herein we show that the maternally imprinted gene Zac1 is a critical regulator of neocortic

300 ge progression, we focused on the maternally imprinted gene Zac1.