ライフサイエンスコーパス: improper

1 Improper access to the genome leads to translocations an

2 lity to bind and bundle actin in vitro cause improper actin organization in vivo and reduce total tra

3 ernal chromosome sequences by preventing the improper activation of DNA-damage-response pathways but

4 This Fbn2(-/-) phenotype is accounted for by improper activation of latent TGF-beta that selectively

5 Collectively, these findings indicate that improper activation of p38 MAPK is a precursor of consti

6 psid assembly, favoring correct folding over improper aggregation.

7 Disruption of this feedforward loop leads to improper AMPK activation and multiple metabolic defects.

8 iate patient demand that helps to drive much improper antibiotic prescribing.

9 l formation similar to those associated with improper arterial-venous specification.

10 There was inconsistent evidence for improper assignment of ASA and FHS.

11 nnel activity, an effect that was not due to improper association with Gbeta.

12 Improper attachment of the mitotic spindle to the kineto

13 dynamically modifies kinetochores to correct improper attachments and ensure faithful chromosome segr

14 es (PEFs), highest near poles, can stabilize improper attachments by pushing mal-oriented chromosome

15 Improper attachments typically lack tension between kine

16 on specific mechanisms to avoid and resolve improper attachments.

17 efficient B-cell regulation may influence an improper balance between an effector inflammatory respon

18 ing domains are implicated in cancer through improper binding of chromatin.

19 nally, AraC protein also acts to prevent the improper binding of RNA polymerase at a pseudo promoter

20 ion for proper binding and selection against improper binding.

21 gnal-dependent activation and/or resulted in improper biological outputs.

22 cruitment to the spindles, thus resulting in improper bipolar spindle formation that ultimately leads

23 Disruption of the PBD function results in improper bipolar spindle formation, chromosome missegreg

24 Podocyte depletion may result from improper calcium handling due to abnormal activation of

25 due to spatial heterogeneity of the nucleus, improper calibration of the FCS focal volume, or the int

26 n trabecular bone occur independently of the improper cartilage ECM degradation caused by Mmp13 defic

27 rosine kinase cSrc are infertile and exhibit improper cauda epididymis development.

28 Importantly, improper CCK infusion methodology can result in an erron

29 ase activity is indispensable for preventing improper cell cycle re-entry and endoreduplication.

30 ng showed an elongated phenotype, indicating improper cell division.

31 microscopy, we observe adhesion complexes at improper cell surfaces and disoriented cytoskeletal fila

32 estes and initiate spermatogenesis; however, improper cellular associations and abnormal sperm format

33 Improper cellular expression of the W4.64A was observed

34 nd-like 1 (MBNL1) is a splicing factor whose improper cellular localization is a central component of

35 the frameshift deletion and that demonstrate improper cellular localization.

36 arget area and branch aberrantly, leading to improper cellular positioning.

37 e they reduce the curdling of milk and cause improper cheese ripening, which consequently lead to an

38 The improper choice of negative examples, in particular, can

39 patched was disrupted in mutants, reflecting improper chondrocyte/perichondrium signaling.

40 ell as small prometaphase-like spindles with improper chromosomal attachments.

41 s with aberrant kinetochore-MT interactions, improper chromosome alignment and abbreviated mitosis.

42 tions in the Drosophila gene greatwall cause improper chromosome condensation and delay cell cycle pr

43 These attachments can result in improper chromosome segregation and are a significant so

44 rstanding genetic disorders that result from improper chromosome segregation.

45 about the severity of AK and consequences of improper CL hygiene.

46 In infarcted heart, improper clearance of dying cells by activated neighbori

47 Improper clearing of acetylcholine and prolonged excitat

48 Ipl1 released these improper connections, whereas Mps1 triggered the formati

49 Improper contact lens care and contact with nonsterile w

50 mation but short enough to limit roaming and improper contacts with heads of neighboring tetramers.

51 ering-permissive conformation while avoiding improper contacts with heads of neighboring tetramers.

52 variability in metabolic data and the use of improper control groups.

53 PG had structural alterations indicative of improper cortex PG synthesis, including twofold decrease

54 multiple pathways, raising the potential for improper cross talk.

55 A new study reveals both the consequences of improper crossover patterning in Drosophila and the role

56 ion along MAdCAM-1 substrates resulting from improper de-adhesion of the lymphocyte trailing edge.

57 The zu405 mutation results in improper degradation of the OMA-1 protein in embryos.

58 ficiencies of CGD, specifically finding that improper degranulation of leukocytes did not explain the

59 uced FA use in heart failure may result from improper delivery, potentially via decreased perilipin 5

60 genes contributes to tumor progression, the improper dependency of H3K27me3 by mC in immortalized ce

61 s leads to compromised myocardial integrity, improper deposition of basement membrane, and a resultan

62 erized by the presence of myofibroblasts and improper deposition of extracellular matrix (ECM) compon

63 ed with abnormalities in the exoskeleton and improper development of the epidermis.

64 l retardation, as the TH decrease results in improper development of the nervous system.

65 The improper development of these structures in nhr-6(lg6001

66 Hereditary deafness is often mediated by the improper development or degeneration of cochlear hair ce

67 rowth and function of the vertebrate eye and improper development results in congenital defects, such

68 he disease is probably underestimated due to improper diagnostic pathway.

69 Moreover, subplate neurons underwent improper differentiation and premature cell death during

70 Congenital heart defects often result from improper differentiation of cardiac progenitor cells.

71 s a childhood tumor thought to arise through improper differentiation of neural crest cells.

72 Improper differentiation of the central cell led to defe

73 Deletion of COUP-TFII at E7.5 results in improper differentiation of the metanephric mesenchyme a

74 ial hyperplasia, aberrant DNA synthesis, and improper differentiation.

75 eiotic defects in late prophase I, including improper disassembly of the SC and aberrant chromosome c

76 of proper rod outer segment development and improper disc formation.

77 nal therapeutics due to metabolic excretion, improper disposal, and industrial waste has been well-re

78 widespread use as an industrial solvent, its improper disposal, and its substantial emission to the a

79 significant fraction of molecules exhibiting improper disulfide bonding.

80 Improper DNA double-strand break (DSB) repair results in

81 ines, suggesting that RdgB either intercepts improper DNA precursors dITP/dXTP or works downstream of

82 Common error types were improper dose/quantity (46%) and prescribing (25%).

83 ins can cause severe disease associated with improper drug or ion flux.

84 pression of epidermal HDAC activity leads to improper ectodermal organ morphogenesis and disrupted ha

85 Our results suggest that improper editing and failure to sequester autoreactive B

86 f Arhgap29(K326X/+) mice ( n = 37) exhibited improper epithelial contact between developing oral stru

87 lier homology model, which could have led to improper estimation of receptor interaction surfaces and

88 sult in poor performance on examinations and improper evaluation of techniques and materials.

89 ive rise to global methylation errors is the improper expression of one or more of the DNMTs during t

90 e that several Tan mutants are the result of improper expression of the gene cotB.

91 Improper extension of sequence tags can obscure or misle

92 Improper extracellular localization of the latent comple

93 found to be mysteriously abundant in hybrid improper ferroelectric (Ca,Sr)3Ti2O7 crystals.

94 nt of charged conducting domain walls in the improper-ferroelectric Cu3B7O13Cl.

95 Improper ferroelectricity (trimerization) in the hexagon

96 of two types of octahedron rotation, hybrid improper ferroelectricity has been theoretically predict

97 Hexagonal YMnO(3) shows a unique improper ferroelectricity induced by structural trimeriz

98 he possibility of having magnetically driven improper ferroelectricity, as in the much studied famili

99 In CuO, a multiferroic with improper ferroelectricity, the anisotropic THz absorptio

100 trate the unexpectedly rich nature of hybrid improper ferroelectricity.

101 tion in (001) films of layered A3B2O7 hybrid-improper ferroelectrics with experimentally accessible b

102 This particularly applies to improper ferroelectrics, where the polarization is induc

103 caused by the absence of flagella instead of improper flagellar assembly.

104 te-directed mutagenesis of LF2p reveals that improper flagellar length and defective flagellar assemb

105 oss of 4CL activity, probably as a result of improper folding as indicated by molecular modeling.

106 per lipid substrate or MTP may result in the improper folding of apoB and, consequently, its degradat

107 e, presumably due to inefficient assembly or improper folding of the fragments.

108 may function as an RNA chaperone to prevent improper folding of the nascent pre-rRNA.

109 or deletion of the DFGWG motif alone led to improper folding of the transiently expressed GFP fusion

110 suggest that the cataracts resulted from an improper folding status of lens proteins caused by Sep15

111 ence compared with wild-type Rem, suggesting improper folding.

112 are rapidly degraded, most likely because of improper folding.

113 Though we found stemless DNA beacons improper for diagnostic purposes due to high background

114 ecretion of exosome proteins, in part due to improper formation of MVBs.

115 of some of them appears to be linked to the improper formation of protein bodies (PBs) where zein st

116 These defects were accompanied by improper formation of the boundary between dorsal and ve

117 rovides the substrate for cognition, whereas improper formation or function of these synapses leads t

118 regulation of FRO1 in roots and shoots, and improper FRO1 regulation in response to a shoot-derived

119 enzymes and that under certain circumstances improper FtsZ function can destroy the structural integr

120 athways in PS-deficient P. patens implicated improper function of the cytoskeletal network.

121 Improper function of the tumor suppressor protein p53 is

122 Improper function of voltage-gated sodium channels (NaVs

123 An imbalance or improper functioning by the above modulating factors dur

124 into neuropsychiatric diseases that involve improper generalization between different contexts.

125 Improper glucose-stimulated insulin secretion from pancr

126 epletion results in misaligned lamellipodia, improper Golgi positioning, and reduced invasion.

127 own to reduce malaria cases by 50%; however, improper handling and human behavior can diminish their

128 eatures of cancer cells can be manifested by improper histone deacetylation.

129 Improper homeostasis of Th1 and Th2 cell differentiation

130 The sepsis syndrome represents an improper immune response to infection and is associated

131 l improperly predisposing it to be a site of improper implantation of the gestational sac.

132 sponses to chemokines, abnormal trafficking, improper in situ positioning, and loss of polarity compo

133 We suggest three steps to identify improper inferences from migration data and to enhance u

134 (PTSD) is thought to develop, in part, from improper inhibition of fear.

135 GFP-IBD may trigger premature or improper integrase oligomerization.

136 the incomplete list of siRNAs features, (ii) improper integration of the heterogeneous cross-platform

137 sis that their movement defect was caused by improper interaction between the P22 mutants and one or

138 rant trafficking of the altered proteins and improper interaction with components of the cytoskeleton

139 nvironments, underscores the need to prevent improper interactions during folding and refolding of me

140 Consequently, scoring function terms for improper interactions received little weight in paramete

141 proteins and functional alterations, such as improper interactions with other proteins.

142 r periphery, FSHD likely arises instead from improper interactions with transcription factors or chro

143 y and recovery thereof that may even lead to improper interpretation of results.

144 operly into the clear fiber state and to the improper involution of cells from the anterior epitheliu

145 cal and experimental evidence indicates that improper involution plays a role in the development of t

146 urely to kinetochores and spindle, cementing improper k-MT attachments and leading to high rates of l

147 C1 function, which leads to skin ulceration, improper keratinocyte adhesion, and cancer formation in

148 isease, characterized by skin ulceration and improper keratinocyte adhesion.

149 Improper kinetochore attachments activate the spindle as

150 his tension contributes to the correction of improper kinetochore attachments and is opposed by the c

151 MCAKs act at kinetochores to correct improper kinetochore-microtubule (k-MT) attachments, and

152 Aurora B functions to correct improper kinetochore-microtubule attachments and alert t

153 mechanism causing CIN is the persistence of improper kinetochore-microtubule attachments called mero

154 osome misalignment and missegregation due to improper kinetochore-microtubule attachments.

155 er chromosome congression, and correction of improper kinetochore-microtubule attachments.

156 or Kin Is in prevention and/or correction of improper kinetochore-microtubule attachments.

157 Phosphorylation by Aurora B, which corrects improper kinetochore-microtubule connections in vivo, re

158 ured osteoblasts from Fbn1(-/-) mice exhibit improper latent TGF-beta activation as well, but mature

159 in SLOS is defective Ret signaling owing to improper lipid raft composition or function.

160 me splitting, which we attribute in part, to improper localisation of the nuclear envelope protein TP

161 These data suggest that, in MFS, improper localization of latent TGFbeta complexes compos

162 Moreover, improper localization of these regulators hinders expans

163 that lack tumor-suppressor activity present improper localization.

164 ipi* states are shown to be artifacts of the improper long-range behavior of standard density-functio

165 ral neurodegenerative diseases, resulting in improper loss of neurons.

166 defective lymphovenous valve morphogenesis, improper lymphatic drainage, defective lymphatic valve m

167 se presentations of CSC is critical to avoid improper management.

168 Improper mass calibration, inadequate instrument optimiz

169 ion of either half of Ptc1 alone resulted in improper maturation of the protein and a failure to comp

170 ults suggest that the neonatal lesion causes improper maturation, but not loss, of PFC interneurons d

171 Improper mechanical ventilation settings can exacerbate

172 rs aquatic environments through patient use, improper medicine disposal, and production.

173 Improper meiotic chromosome segregation causes condition

174 xcessive values reported due to selection of improper method of determination of Se in mushrooms rela

175 Improper methodology and reporting of RCTs can lead to e

176 rgence-time estimates were generated through improper methodology on the basis of a single calibratio

177 How kinetochores correct improper microtubule attachments and regulate the spindl

178 iated kinesin (MCAK) are required to release improper microtubule attachments.

179 We show that improper microtubule-chromosome attachment (merotely) is

180 l1/Aurora B protein kinase that destabilizes improper microtubule-kinetochore attachments.

181 any motor neurons from affected animals show improper mitochondrial distribution, characterized by ti

182 umulation at G(2)/M, massive DNA damage, and improper mitotic chromosome condensation.

183 -Set7 expression upon loss of HCF-1 leads to improper mitotic H4-K20 methylation and cytokinesis defe

184 f the Wnt pathway resulting from mutation or improper modulation of pathway components contributes to

185 confers low CYP3A5 expression as a result of improper mRNA splicing.

186 roscopy that intersublattice exchange in the improper multiferroic cupric oxide (CuO) creates electro

187 rger mass of oligosaccharides, indicative of improper N-linked glycosylation addition and/or trimming

188 , aberrant IL-6 transcription is mediated by improper NF-kappaB p65 phosphorylation and nuclear local

189 dimers in the asymmetric unit arranged in an improper non-crystallographic 10-fold relationship, and

190 Improper nuclear localization of 4qter is discussed as a

191 We conclude that improper nuclear positioning contributes to muscle dysfu

192 These results link improper nuclear positioning specifically to the death o

193 eterogeneities, cell cycle asynchronies, and improper nuclear reprogramming.

194 sity to lack flagella or produce flagella in improper numbers or at nonpolar locations, indicating th

195 resolution limit makes partition density an improper objective function for global optimization.

196 These results suggest that the improper oligomeric assembly of DISC1-S704C may underlie

197 or more phases of this process, thus causing improper or impaired wound healing.

198 Improper or inadequate actions taken after blood and bod

199 nstrate that mutations in region B result in improper orientation of Pit1 in the cell membrane.

200 ic4 and Tic4 analogues is probably due to an improper orientation of the aromatic ring in these resid

201 ticularly in the spermatozoa midpiece due to improper oxidation and polymerization of sperm capsular

202 This is exemplified by improper pairing and synapsis of homologous chromosomes

203 orate correct nucleotides as well as to form improper pairings.

204 Improper pathway activation causes defects in axonal gui

205 Loss of Sema3d leads to improper patterning of the coronary veins, a phenotype r

206 These defects ultimately result in improper patterning of the embryonic central nervous sys

207 ked with cardiac dysfunction, allows for the improper physiological response in maintaining glucose a

208 Improper placement of nasogastric tube used for feeding

209 riphosphate (CTP) at position 76 arises from improper placement of the alpha phosphate of the incomin

210 s with preserved transport activity but with improper plasma membrane localization for rescue by the

211 chanism, failure in this process resulted in improper Plk1 recruitment to kinetochores, mitotic arres

212 ation defects in mRNA export mutants include improper Pol II termination and/or the previously charac

213 quality control mechanisms that exclude the improper polymerase from a particular strand.

214 iminished replication, likely as a result of improper positioning of templates at the catalytic site.

215 rs plana vitrectomy (PPV) can occur owing to improper positioning of the infusion cannula in the supr

216 Improper post-exposure practices were identified, 9.8% d

217 ts in vitro, and the deletion of Mmp9 caused improper processing of DSP in natural teeth.

218 of paramount importance to all organisms, as improper progression through the cycle could result in d

219 L/+) mice an Ins2-Akita mutation that causes improper protein folding and islet apoptosis to lower pl

220 Our hypothesis is that improper protein maturation and incompletely folded stat

221 Vis-a-vis virion morphogenesis, an improper protein-protein interaction within an early ass

222 ically on the ratio of VEGF to BMP4, with an improper ratio leading to detrimental effects on bone he

223 quiescent or differentiated cells results in improper re-entry into the cell cycle, again in an appar

224 roposed desolvation mechanism is based on an improper reference state; (ii) a nonpolar active site ca

225 Improper regeneration of the alveolar epithelium is ofte

226 afforded only a non-natural analogue through improper regiocontrol.

227 is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency disea

228 The data indicates that patients with improper regulation in the concentration of specific acu

229 stem has evolved to annul pathogens, but its improper regulation is linked with diseases.

230 Pmk1 activation in the absence of Mst11 and improper regulation of appressorium formation, the direc

231 The consequences of improper regulation of collagen turnover include disease

232 DSBs are necessary for CSR, but improper regulation of DSBs can lead to chromosomal tran

233 ss of E6AP catalytic activity and likely the improper regulation of E6AP substrate(s) are important i

234 We found that improper regulation of IL-1beta production resulted in s

235 ution simulation of spc98/+ mutants revealed improper regulation of interpolar (iMT) and kinetochore

236 Several disease states are associated with improper regulation of nitric oxide production, making N

237 However, improper regulation of PCD by NF-kappaB can have severe

238 and age-related diseases that are linked to improper regulation of S6K1.

239 Improper regulation of this pathway has implications for

240 text of Hh signaling, or the consequences of improper regulation.

241 forming clinical research, and the potential improper remuneration of researchers or research subject

242 Improper repair of closely opposed lesions could lead to

243 ntered using the graft's delivery system and improper reporting to the Food and Drug Administration.

244 Improper representation of surface conditions in CNTL ru

245 Taken together, these results suggest that improper repression of MeCP2, secondary to trisomic over

246 loss of Mef2c in skeletal muscle results in improper sarcomere organization.

247 We examine factors such as improper scaling and biases in species representation as

248 tion of injuries classically associated with improper seat belt fit in children.

249 nt repair of double-stranded DNA breaks, and improper segregation of sister chromosomes.

250 can cause genomic instability resulting from improper segregation of the broken fragments into daught

251 Improper sensitivity settings alter the detected percent

252 ects in heart development, consisting of the improper septation of the cardiac outflow tract (OFT) an

253 sting of interruption of the aortic arch and improper septation of the cardiac outflow tract.

254 Improper setup can result in equipment malfunction or ma

255 Efforts to halt improper sewage disposal in oyster-harvesting waters, in

256 The neural defects are associated with improper Shh expression in the underlying rostral axial

257 al trafficking of K(ATP) channels by causing improper shielding of the RKR endoplasmic reticulum rete

258 Improper signaling of the IL-36 receptor (IL-36R), a mem

259 disrupted in tumour cells, resulting in the improper silencing of tumour-suppressor genes associated

260 ulin-A(SP24)D is inefficiently cleaved at an improper site, producing two subpopulations of molecules

261 exponential growth and initiate growth from improper sites as they exit stationary phase.

262 98hc deletion in murine epidermis results in improper skin homeostasis and epidermal wound healing.

263 We showed that improper Smad2/3 signaling in Fbn1-null VSMC is in part

264 Improper spatiotemporal expression of RA during developm

265 esult from its intrinsic nature and not from improper specimen collection.

266 positioned spindle rather than inhibited by improper spindle position.

267 Huntington disease muscle was compromised by improper splicing and a corresponding reduction in total

268 dietary assessment tools, measurement error, improper statistical analyses, and a lack of heterogenei

269 ificant underestimates of concentrations and improper statistical model validation that, in turn, can

270 the embryonic trachea that might result from improper stratification of the embryonic tracheal epithe

271 letion of a single allele of Gli1 results in improper stromal remodeling and perdurance of the inflam

272 2 and KPNA2, which is likely responsible for improper subcellular localization of DeltaValBRCA1.

273 pling may be falsely detected when employing improper surrogate methods.

274 In this model, an incomplete or improper switch would kinetically trap intermediates.

275 iscriminated, irrespective of their average (improper) symmetry.

276 Improper synapse formation in Spag6KO mice was associate

277 d GATA3 in the nascent TE lineage results in improper TE development, leading to failure in embryo im

278 (b) the discrimination between a proper and improper termination occurs via an internal, Upf1-depend

279 tributed to Rankl up-regulation secondary to improper TGFbeta activation and signaling.

280 processing in stathmin(-/-) females leads to improper threat assessment, which in turn affects innate

281 However, whether these defects contribute to improper tissue building in vivo requires further clarif

282 hampered by sub-optimal expression levels or improper tissue-specificity of particular promoters, or

283 A widely used assay to identify mutants with improper TPEV employs the URA3 gene at the telomere of c

284 ide components, thereby clearing the cell of improper translation products and defective components o

285 amino acid substitution in Npt2a can lead to improper translocation of the protein to the cell membra

286 n circulation may result in misdiagnosis and improper treatments.

287 efective IGF-IR tyrosine phosphorylation, or improper tyrosine phosphorylation of IRS-1.

288 P1 mutant mice also had improper ureteral bladder insertion sites and shortened

289 ally normal, E15.5 Fgfr2(ST-/-) mice exhibit improper ureteral insertion sites into the bladder, cons

290 omes through incorrect diagnosis of disease, improper use of a given therapy, and irreproducible rese

291 s from these studies were also rated for the improper use of causal language and biased interpretatio

292 misleadingly citing others' results, and 4) improper use of causal language in citing others' work.

293 ased interpretation of one's own results, 2) improper use of causal language in describing one's own

294 ination of Se in mushrooms relate largely to improper use of flame atomic absorption spectroscopy (AA

295 ain contributors to poor health outcomes and improper use of health care among immigrants.

296 ures, as well as to identify adulteration by improper use of the rye-wheat flour ratios in bread maki

297 ansmission is limited due to inconsistent or improper use, as well as physical decay in effectiveness

298 through questionable experimental design or improper validation methods.

299 an absence of labyrinth formation causing an improper vascularization of the placenta.

300 Many of the mutants formed improper viral DNA ends and were less efficient in PPT-U