ライフサイエンスコーパス: impulsive

1 These steep discounters are considered impulsive.

2 neral move faster than subjects who are less impulsive.

3 Teenagers are often impulsive.

4 AR) promote and 5-HT2AR antagonists suppress impulsive action (the inability to withhold premature re

5 el described the data well, with measures of impulsive action and choice separating into two independ

6 Thus, impulsive action and cue reactivity appear to neuromecha

7 These data support the conclusion that impulsive action and impulsive choice are distinct behav

8 To test the hypothesis that impulsive action and impulsive choice represent statisti

9 lunteers to examine the role of serotonin in impulsive action and impulsive choice.

10 At a higher dose (3 mug), M-NX eliminated impulsive action and returned PR breakpoint to low-drive

11 Therefore, adolescent CORT exposure reduced impulsive action but increased impulsive choice, indicat

12 Using two approaches, we dissociated impulsive action from impulsive choice.

13 hoice serial reaction time task, we measured impulsive action in 1) a panel of 41 BXD recombinant inb

14 cessary and sufficient for the expression of impulsive action in a high-arousal, high-drive appetitiv

15 Intra-PFC M-NX nearly eliminated impulsive action in DRL engendered by hunger, at a dose

16 Genetic mapping of impulsive action in the BXD panel identified a locus on

17 T1BR expression was a predictor of increased impulsive action only.

18 tion time (1-CSRT) task was used to identify impulsive action phenotypes in an outbred rat population

19 aneously occurring individual differences in impulsive action reflect variation in the cortical 5-HT2

20 ctive 5-HT2AR antagonist M100907 to suppress impulsive action relative to LI rats.

21 een Nrg3 expression in the mPFC and level of impulsive action shown here provides a mechanism by whic

22 mpulsive behavior are behavioral inhibition (impulsive action) and delayed gratification (impulsive c

23 ly increased 4-CSRTT premature responses (or impulsive action), which is remarkably similar to the pr

24 task, which differentially assess attention, impulsive action, and impulsive choice.

25 st, the absence of 5-HT1BRs caused increased impulsive action, but not impulsive choice.

26 enes regulating impulsivity, specifically of impulsive action, in mice.

27 Virally increasing Crem levels decreased impulsive action, thus establishing a causal relationshi

28 ity locus (Impu1) confirmed its influence on impulsive action.

29 salience coding, and impulsive choice versus impulsive action.

30 thought to play a role in the regulation of impulsive action.

31 )), may drive the predisposition to inherent impulsive action.

32 c loss of the mPFC 5-HT2CR induced aggregate impulsive action/cue reactivity, suggesting that depress

33 indicating heightened stress, in response to impulsive additional noise (playbacks of recordings of p

34 Impulsive aggression (IA) in adults is associated with b

35 Impulsive aggression and borderline personality disorder

36 ior, studies of white matter connectivity in impulsive aggression are warranted.

37 spring mood disorder at each time point, and impulsive aggression as a precursor of mood disorder.

38 A disorder of impulsive aggression has been included in DSM since the

39 orts the hypothesis that lithium use reduces impulsive aggression in addition to stabilizing mood.

40 Interventions that target mood disorder and impulsive aggression in high-risk offspring may attenuat

41 munoreactivity concentration and measures of impulsive aggression in human subjects.

42 cture of the central neuromodulatory role of impulsive aggression in human subjects.

43 cture of the central neuromodulatory role of impulsive aggression in human subjects.

44 bsequently, renewed interest in disorders of impulsive aggression led to a recent series of community

45 familial transmission (eg, mood disorder and impulsive aggression).

46 rs, such as depression, childhood abuse, and impulsive aggression, report inconsistent results.

47 n and impulsivity and a composite measure of impulsive aggression.

48 centration were accounted for by measures of impulsive aggression.

49 ygdala circuits have long been implicated in impulsive aggression.

50 antisuicidal properties through reduction in impulsive aggression.

51 s the categorical expression of pathological impulsive aggression.

52 ts with histories of recurrent, problematic, impulsive aggressive behavior and in nonaggressive compa

53 trol study in a clinical research program in impulsive aggressive behavior at an academic medical cen

54 in individuals with recurrent, problematic, impulsive aggressive behavior.

55 tion similarly between animals expressing an impulsive-aggressive phenotype, as compared to normal an

56 Crtc1(-/-) mice exhibit impulsive aggressiveness, social withdrawal, and decreas

57 Impulsive and aggressive behaviors are both modulated by

58 t with management of developmentally limited impulsive and aggressive behaviors rather than psychotic

59 The data indicate a convergence of impulsive and aggressive characteristics to one phenotyp

60 creased serotonin metabolites with increased impulsive and aggressive traits.

61 rical disorder of ADHD influence hyperactive-impulsive and attentional traits in the general populati

62 The disconnection lesion led to both impulsive and compulsive behavior.

63 al systems and their role in contributing to impulsive and compulsive features of drug dependence.

64 By contrast, increased levels of impulsive and compulsive personality traits and limbic-s

65 e that prenatal nicotine exposure makes rats impulsive and disrupts firing of mPFC neurons that carry

66 e left and right dorsal striatum of both low-impulsive and high-impulsive rats.

67 nt of frontotemporal dementia, presenting as impulsive and impetuous behaviours that are often diffic

68 V with symptoms of ADHD domains (hyperactive/impulsive and inattentive) and symptoms of CD as well as

69 ted dopamine transmission is associated with impulsive and maladaptive behavior.

70 l illness whose manifestations often include impulsive and risk-taking behavior.

71 Our findings suggest that clinically impulsive and risky decision-making are related to subje

72 mechanisms underlying a range of affective, impulsive, and aggressive neuropsychiatric disorders.

73 Using an ADHD rat model, we demonstrate that impulsive animals are neurochemically and behaviorally m

74 nted the development of compulsivity in high-impulsive animals.

75 d system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psy

76 al magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively pre

77 network perturbation engenders disorganized, impulsive appetitive responses.

78 ns drives proximate reward bias by promoting impulsive approach to nearby reward-associated objects.

79 ive/inattentive (ASRS part A), hyperactivity/impulsive (ASRS part B), and combined (total) ASRS score

80 impulsive traits (BIS-11 questionnaire) and impulsive behavior (by means of the Delay Discounting Qu

81 sorder, bipolar disorder, schizophrenia, and impulsive behavior all share in common defects in these

82 ne D(2)-like receptors have been linked with impulsive behavior and behavioral inhibition in rodents,

83 Effects of lead exposure on impulsive behavior and cognition were modified by mercur

84 Two behavioral features often considered in impulsive behavior are behavioral inhibition (impulsive

85 Dysregulation of impulsive behavior by increased DYN/KOR activity could s

86 associated with DNMT1 upregulation, whereas impulsive behavior could be dissociated from inattention

87 a distinct set of 5-HT1B receptors modulates impulsive behavior during adulthood.

88 inhibition deficiency related to hyperactive-impulsive behavior in ADHD, further emphasizing the poss

89 Lesions of AI reduced impulsive behavior in HI rats, which were also highly su

90 ive control, heightens the predisposition to impulsive behavior in juvenile offenders.

91 Impulsive behavior is a hallmark of several neuropsychia

92 however the relationship between orexin and impulsive behavior is incompletely characterized.

93 Impulsive behavior is thought to reflect a traitlike cha

94 Here, we investigated whether impulsive behavior observed following cocaine exposure r

95 Rats were screened for impulsive behavior on a five-choice serial reaction time

96 Rats were screened for impulsive behavior on the five-choice serial reaction ti

97 For example, hyperactive-impulsive behavior scores at age 8 years were 0.9 points

98 Impulsive behavior such as steep temporal discounting is

99 The impulsive behavior that is often characteristic of adole

100 Hyperlocomotion and impulsive behavior were reversed by methylphenidate, a p

101 r, neither ATO nor MPH significantly altered impulsive behavior when infused into the prelimbic or in

102 is implicated in mood regulation, control of impulsive behavior, and in processing aversive and rewar

103 Alcohol use may also increase impulsive behavior, including impaired response inhibiti

104 selective roles in regulating compulsive and impulsive behavior, respectively.

105 serotonin (5-HT) receptors are implicated in impulsive behavior, separate groups of rats received mic

106 information processing mechanism underlying impulsive behavior, we investigated stimulus and action

107 educing serotonin neurotransmission promotes impulsive behavior.

108 n give rise to the various manifestations of impulsive behavior.

109 nism of short-term and long-term patterns of impulsive behavior.

110 tion may be of use in correcting maladaptive impulsive behaviors and provide further evidence for dis

111 nhibition may underlie some of the risky and impulsive behaviors observed in high sensation seekers.

112 y economic models hold that instrumental and impulsive behaviors underlie human social decision makin

113 Rodent research has focused largely on impulsive behaviors, often gauged by premature respondin

114 the central-medial amygdala, which subserves impulsive behaviors.

115 stress levels, anger proneness, and hostile, impulsive behaviors.

116 s in genetic and molecular investigations of impulsive behaviors.

117 uropsychological measures of inattentive and impulsive behaviors.

118 to quantify the hyperactive, inattentive and impulsive behaviour associated with ADHD.

119 ovide further evidence of STN involvement in impulsive behaviour in the PD population.

120 ay promote innovation as well as problematic impulsive behaviour, including drug abuse.

121 o the existence of dissociable components of impulsive behaviour, they inform the human literature, a

122 ubthalamic nucleus deep-brain stimulation on impulsive behaviour.

123 ing for the future may encourage apparently "impulsive" behaviour when the future is anticipated to b

124 otype of cocaine dependence characterized by impulsive behaviours and compulsive drug-taking.

125 Knockout of Htr2b increased impulsive behaviours in mice, indicative of predictive v

126 associated with a presumably more efficient impulsive brain system, manifested through reduced grey

127 basolateral amygdala led rats to become more impulsive by affecting preference for smaller immediate

128 rsistence of inattentive than of hyperactive/impulsive childhood symptoms of ADHD in adulthood but al

129 self-administered cocaine displayed greater impulsive choice (enhanced preference for the small imme

130 ocaine use is associated with high levels of impulsive choice (preference for immediate over delayed

131 ial cognition, social function, and level of impulsive choice also remained undisturbed.

132 ort the conclusion that impulsive action and impulsive choice are distinct behavioral phenotypes with

133 There was no effect of TD on impulsive choice as indexed by the reward delay-discount

134 Animals were screened for aggressive and impulsive choice behaviors and categorized into Low-Aggr

135 raising cortical dopamine levels attenuates impulsive choice by changing corticostriatal function.

136 oint and play a critical role in suppressing impulsive choice by regulating decision trade-off.

137 or bipolar disorder or suicide to modify the impulsive choice dimension of this diseases.

138 le functional roles of the mOFC and lOFC for impulsive choice in rodents.

139 ivation of 5-HT1A receptors in OFC increases impulsive choice in the adjusting delay procedure.

140 evated impulsive choice, or whether elevated impulsive choice is solely a predisposing factor for coc

141 mpulsive choice, and that the high levels of impulsive choice observed in human cocaine users may be

142 Rats were trained with an impulsive choice procedure between an adjusting smaller

143 est the hypothesis that impulsive action and impulsive choice represent statistically independent beh

144 underpins value versus salience coding, and impulsive choice versus impulsive action.

145 In the present experiments, impulsive choice was assessed by evaluating intolerance

146 Impulsive choice was not altered significantly by MPH, A

147 al effects between groups, as aggression and impulsive choice were both inhibited in H-Agg animals, w

148 impulsive action) and delayed gratification (impulsive choice).

149 ceipt, is an established behavioral model of impulsive choice, a key component of a broader impulsivi

150 ered cocaine can cause lasting elevations in impulsive choice, and that the high levels of impulsive

151 osure reduced impulsive action but increased impulsive choice, indicating that chronic stress hormone

152 ot clear whether cocaine use causes elevated impulsive choice, or whether elevated impulsive choice i

153 and eticlopride infused into mPFC increased impulsive choice, whereas 8-OH-DPAT infused into OFC dec

154 he role of serotonin in impulsive action and impulsive choice.

155 whereas 8-OH-DPAT infused into OFC decreased impulsive choice.

156 e the systemic effect of ADHD medications on impulsive choice.

157 ng state VLF oscillations during waiting and impulsive choice.

158 ally assess attention, impulsive action, and impulsive choice.

159 ase reversed this relationship, resulting in impulsive choice.

160 enhance learning from rewarding outcomes and impulsive choice.

161 ay discounting task commonly used to measure impulsive choice.

162 s caused increased impulsive action, but not impulsive choice.

163 were sufficient to bidirectionally influence impulsive choice.

164 oaches, we dissociated impulsive action from impulsive choice.

165 that uses positive reinforcement to replace impulsive cocaine use with constructive personal goals.

166 Moreover, COMT knockout mice were more impulsive compared with wild-type littermates.

167 y contributes to individual vulnerability to impulsive-compulsive behavior in rats.

168 linical and structural imaging predictors of impulsive-compulsive behaviour (ICB) in de novo Parkinso

169 with eight patients exhibiting more than one impulsive-compulsive behaviour.

170 r the broader debate on the relation between impulsive-compulsive behaviours and addictions and may h

171 Impulsive-compulsive behaviours are a significant source

172 The group with Parkinson's disease with impulsive-compulsive behaviours had a greater reduction

173 The impulsive-compulsive behaviours included hypersexuality,

174 ues among a group of patients with different impulsive-compulsive behaviours is consistent with a glo

175 ts with Parkinson's disease with and without impulsive-compulsive behaviours on striatal levels of sy

176 Eighteen patients (11 with and seven without impulsive-compulsive behaviours) underwent three (11)C-r

177 Depression Inventory, and Questionnaire for Impulsive-Compulsive Disorders in Parkinson Disease Rati

178 SPECT) and ICD assessment (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease sh

179 d as positive score on the Questionnaire for Impulsive-Compulsive Disorders in PD.

180 e disorder, in a potentially new spectrum of impulsive-compulsive disorders.

181 e to pathological computational processes in impulsive/compulsive psychiatric disorders.

182 that relapse to smoking is due to a lack of impulsive control, which is thought to be due to altered

183 -to-ground lightning flashes, manifesting an impulsive coupling mechanism between lower and upper atm

184 (F1,38 = 4.34, P = 0.04) problems, were less-impulsive decision makers (F1,37 = 6.76, P = 0.01), and

185 Hypomania is associated with impulsive decision making and risk taking, characteristi

186 investigate the effect of STN stimulation on impulsive decision making, we used the Iowa Gambling tas

187 e extent to which these tendencies relate to impulsive decision-making and behaviors in real-life set

188 unt of disorders characterized by clinically impulsive decision-making, and provide targets for evalu

189 ICD subtypes assessed by modified Minnesota Impulsive Disorder Interview (mMIDI).

190 Furthermore, the pro-impulsive effects of KOR activation were rescued by pret

191 s through the application of intense fields, impulsive electromagnetic stimulation, and nanostructuri

192 ts of 5-HT3 receptor included repetitive and impulsive elements of behavior, pointing to the importan

193 Notably, when the initial impulsive erroneous response was avoided, PIGD and TD gr

194 cts exhibited less conflict effects and less impulsive errors in sustained attention compared with th

195 Impulsive errors thus entail both a motor system capture

196 zation task that enticed the animals to make impulsive errors.

197 cal, social or virtual--are relieved through impulsive events, it is natural to focus on the attribut

198 es generated under resonant and off-resonant impulsive excitation conclusively reveals coherent wavep

199 ly understood, and could be dominated by the impulsive flash of thermonuclear energy, prolonged optic

200 d discount functions were steeper (i.e. more impulsive) for choices in which the decision-maker was t

201 The myosin cross-bridge applies impulsive force to actin while consuming ATP chemical en

202 These pulses produce high fidelity impulsive forces that separate the atom into widely sepa

203 ed in terms of a harmonic oscillator with an impulsive forcing, and this hypothesis is consistent wit

204 sk reliably and reproducibly identified high impulsive (HI) and low impulsive (LI) action phenotypes;

205 Stable high-impulsive (HI) and low-impulsive (LI) phenotypes were id

206 egion of the insular cortex, in which highly impulsive (HI) rats expressed lower zif268 mRNA levels.

207 /6J (B6) mice (alcohol preferring) were more impulsive in the 5CSRTT than DBA2/J (D2) mice (alcohol a

208 t in unmotivated behavior and high levels in impulsive, inaccurate choices, but that near-optimal per

209 functional connectivity similar to the more-impulsive incarcerated juveniles, whereas older subjects

210 Here we perform exon-focused sequencing of impulsive individuals in a founder population, targeting

211 es underlying the increased vulnerability of impulsive individuals to develop cocaine addiction remai

212 ivity with DLPFC and PPC, especially in more impulsive individuals, and the relationship between impu

213 20*) was reported to segregate with severely impulsive individuals, whereas 5-HT2B mutant (Htr2B(-/-)

214 s, relative to willpower, especially in more impulsive individuals.

215 s context, photo-excitation is treated as an impulsive injection of electronic energy that is transfe

216 f primary (selfish, uncaring) and secondary (impulsive, irresponsible) psychopathic personality trait

217 In less-impulsive juveniles and normal controls, motor planning

218 In more-impulsive juveniles, these same regions correlated with

219 rmal electrons, which are generated in small impulsive ( less, similar30 seconds) heating events call

220 cibly identified high impulsive (HI) and low impulsive (LI) action phenotypes; HI action predicted hi

221 , neuronal, and glial protein markers in low-impulsive (LI) and high-impulsive rats.

222 Stable high-impulsive (HI) and low-impulsive (LI) phenotypes were identified from an outbre

223 in receptor (OXR) antagonists on measures of impulsive-like behavior in rats were evaluated using the

224 ts exhibited significantly greater levels of impulsive-like behavior in this test relative to adults-

225 Furthermore, hyperactive-impulsive-like behavior was induced by reducing the expr

226 , working memory and attention deficits, and impulsive-like behavior.

227 l performance, while increased ITI increased impulsive-like premature responses and decreased trials

228 ese changes coincided with perseverative and impulsive-like responding for sucrose pellets and sustai

229 2R signaling coincide with perseverative and impulsive-like responding for sucrose, a disaccharide co

230 d and applied them to develop a bio-inspired impulsive mechanism that maximizes momentum transfer to

231 ients, PIGD patients made significantly more impulsive motor errors.

232 ory and movement processing and suggest that impulsive movements arise when sensory processes become

233 ynamics and give insight into the frequently impulsive nature of reconnection in space and laboratory

234 ort a translational neuroscience approach to impulsive neurological disorders and indicate the potent

235 xplain why fish that experienced 12 weeks of impulsive noise showed no differences in stress, growth

236 Collies were more impulsive on average, consistent with the original purpo

237 activation reduces food intake and inhibits impulsive operant responding for palatable food via down

238 ve association with ADHD traits (hyperactive-impulsive, p = .0039; inattentive, p = .037).

239 les, whereas older subjects exhibited a less-impulsive pattern.

240 users, but not controls, became increasingly impulsive, performing more rapidly at the expense of acc

241 ehavior, but only among men with dominant or impulsive personality styles.

242 n and response regulation as well as anxious-impulsive personality traits may represent endophenotype

243 eir siblings also exhibited elevated anxious-impulsive personality traits relative to healthy compari

244 efore, KOR activation was shown to induce an impulsive phenotype that was nor-BNI-sensitive.

245 onstrated a dissociable effect of U50,488 on impulsive phenotypes related to intolerance to delay or

246 ized that KOR activation could contribute to impulsive phenotypes.

247 solution-grown single crystals provides the impulsive population transfer necessary to create a cohe

248 errors indicated that stimulation increased impulsive, premature responding in high conflict situati

249 the compulsiveness for food in Low- and High-impulsive rats by measuring the food eaten in the aversi

250 te that the reduction in impulsivity in high-impulsive rats by prior cocaine exposure may be mediated

251 eft, but not right, ventral striatum of high-impulsive rats compared with low-impulsive rats.

252 High- and low-impulsive rats identified in the five-choice serial reac

253 In transition-stage tests, low-impulsive rats showed a significant dose-dependent reduc

254 ovel markers underlying the vulnerability of impulsive rats to cocaine addiction that localize to the

255 Then, we allowed Low- and High-impulsive rats to self-administer a highly palatable die

256 t reduction in cocaine seeking, whereas high-impulsive rats were still unaffected by alpha-flupenthix

257 s, impulsivity selectively decreased in high-impulsive rats withdrawn from cocaine.

258 availability in the ventral striatum of high-impulsive rats, as well as to the left and right dorsal

259 ray matter density in the left NAcbC of high-impulsive rats, with corresponding reductions in this re

260 otein markers in low-impulsive (LI) and high-impulsive rats.

261 esponding (DRL) task to select Low- and High-impulsive rats.

262 tum of high-impulsive rats compared with low-impulsive rats.

263 rsal striatum of both low-impulsive and high-impulsive rats.

264 By combining near-impulsive resonant and non-resonant excitation, the desi

265 t the LHb participates in the suppression of impulsive responding for cocaine through the activation

266 his timing deficit did not seem to be due to impulsive responding or deficits in response inhibition

267 ge range of disorders where subjects exhibit impulsive responding, such as ADHD, mania, chronic subst

268 Following an experimental change to trigger impulsive responding, the sexes showed similar increases

269 establishment of attosecond chronoscopy, the impulsive response of positive-energy electrons to elect

270 sive brain stimulation improved control over impulsive response tendencies, but only when participant

271 ting conflict anticipation to the control of impulsive response, which is consistent with earlier stu

272 d rats tended to have more yohimbine-induced impulsive responses at low doses on this task, which was

273 individual variation in proactive control of impulsive responses remain unknown.

274 a choice reaction-time task known to trigger impulsive responses, leading to fast errors that can be

275 ction, but more in unconscious inhibition of impulsive responses.

276 tection, but less in conscious inhibition of impulsive responses.

277 cognitive control is the ability to rein in impulsive responses.

278 efrontal areas, resulting in the increase of impulsive reward-seeking behaviors that are often observ

279 Impulsive risk taking contributes to deleterious outcome

280 The location of impulsive seismic events indicative of lava reaching the

281 g of choice, and some people might engage in impulsive sexual activity because they are easily arouse

282 rary society, from overeating and obesity to impulsive sexual behavior and STDs.

283 Our theory predicts that people who are more impulsive should in general move faster than subjects wh

284 social-economic decisions and result in more impulsive social-economic choice behavior.

285 aled that PFC dysfunction can lead to either impulsive states with increased tendency to initiate act

286 complementary Brillouin Light Scattering and Impulsive Stimulated Light Scattering coupled with a dia

287 f nanoscale graphite following an ultrafast, impulsive strain excitation.

288 ent quantities while also inferring the bulk impulsive strain profile by using high spatial-resolutio

289 ow that the food addiction phenotype in high impulsive subjects is characterized by an increased expr

290 bility to slow down responses and can induce impulsive suboptimal decisions.

291 represents a valid model for the Hyperactive-Impulsive subtype of ADHD and therefore may be used in f

292 f the combined and predominantly hyperactive-impulsive subtypes of attention-deficit/hyperactivity di

293 ons of childhood inattentive and hyperactive-impulsive symptoms were conducted to predict smoking out

294 cohol dependence, these results suggest that impulsive tendencies in addictions may be reflected in d

295 Personality characteristics, particularly impulsive tendencies, have long been conceived as the pr

296 e found that pathological gamblers were more impulsive than controls in a stop-signal task and attrib

297 Sx-5CSRT, in addition to being screened for impulsive traits (BIS-11 questionnaire) and impulsive be

298 ariability in DA signaling to differences in impulsive traits remain largely unknown.

299 est that the symptom clusters of hyperactive-impulsive type ADHD may have distinct neural and neuroch

300 hen subjected them to a series of controlled impulsive wind gusts delivered by an air piston and expe