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1 but asymmetric in binding-site distribution in a manner that affects cargo dynamics and that cargo c
2 nitude of cell-targeted signaling activation in a manner that agreed with the model predictions, whic
3 aptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in
4 n be controlled by varying the reaction time in a manner that allows for the construction of arrays w
5 1 switch of BsTrpRS positions the Mg(2+) ion in a manner that allows it to assist in transition state
6 ngosine 1-phosphate production in adipocytes in a manner that also depends on hormone-sensitive lipas
7 vation can regulate KCC2 at the cell surface in a manner that alters intracellular chloride and the r
8 f the cytoskeleton both locally and distally in a manner that alters receptor mobility and clustering
9 h of the transmembrane span was seen to vary in a manner that alters the positioning of the gamma-sec
10 levels and induction of cytokine expression in a manner that apparently does not require heparanase
12 A-binding domains surround its helicase core in a manner that appears to be poised for binding to bra
13 tal paths that may guide QSI-based therapies in a manner that avoids or decreases the spread of QSI r
14 that human LAMP1 and LAMP2 bind cholesterol in a manner that buries the cholesterol 3beta-hydroxyl g
15 cts the properties of osmoregulatory neurons in a manner that can affect systemic osmoregulation.
16 rizes dBNST neurons, reducing their activity in a manner that can be blocked by a 5-HT1A antagonist.
17 ad and whisker movements to solve this task, in a manner that can be described by several distinct be
18 nd to a broad array of events (multiplexing) in a manner that can be dynamically modulated by the tas
19 nity data, but they change the sequence data in a manner that can be inconsistent with the process of
20 prepare such structures at will, especially in a manner that can be manufactured, does not exist.
22 nactivation blocks phagosome-lysosome fusion in a manner that can be rescued, in part, with Ca(2+) io
24 ncompetitive, and covalent inhibitors of MIF in a manner that can be scaled for high-throughput scree
25 hat ATR regulates cilia-dependent signalling in a manner that can be uncoupled from its function duri
26 ough its ability to modulate gene expression in a manner that can be used to accurately predict progn
27 criptional or the post-transcriptional level in a manner that can depend on the endogenous L1 nucleot
28 able handheld device, and has been developed in a manner that can easily be adapted to assay differen
29 e, summarize, and analyze the resulting data in a manner that captures significant biological signals
30 spatially coordinate their spiking activity in a manner that closely matches wave propagation measur
31 n HLA-E genes at the B2M locus in human PSCs in a manner that confers inducible, regulated, surface e
32 cross relevant genomic intervals for each SV in a manner that considers variant type, gene features a
33 and simple sugars alters the gut microbiome in a manner that contributes to host adiposity, and refl
34 , Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy, a role that we show is
35 y higher levels of antigenically correct Env in a manner that correlated between cells and cognate vi
36 ined to be critical for virus neutralization in a manner that correlated with antibody recognition of
37 -Arg I enhanced the growth of tumors in mice in a manner that correlated with higher MDSC numbers.
38 the abundance of these cells in murine PanIN in a manner that correlated with inhibition of PanIN pro
39 interactions differed from that of WT RNAP, in a manner that correlated with the presence of consens
40 of synaptic transmission becomes imbalanced in a manner that correlates highly with the level of GAB
41 were found to interact with protein kinase C in a manner that correlates well with the oxidation stat
43 s), KIM-1 expression increased significantly in a manner that corresponded temporally and regionally
44 rise in intestinal transglutaminase activity in a manner that could be inhibited by small molecules t
46 transcriptome of this model would be altered in a manner that could inform human idiopathic ASD, a co
47 de nutrition and physical activity behaviors in a manner that could mitigate disease development or p
48 trically on top of two adjacent Isu1 trimers in a manner that creates two putative [2Fe-2S] cluster a
49 stranded DNA regions upon replication stress in a manner that critically requires its E3 ligase activ
50 MOF74 family, can selectively adsorb oxygen in a manner that defies the classical picture: adsorptio
51 looxygenase 2 (COX-2), not COX-1, expression in a manner that depended on activation of hormone-sensi
52 creased the excitability of BLA neurons, but in a manner that depended on age and BLA subnucleus.
53 somal limiting membranes in unstressed cells in a manner that depended on its FYVE domain and on phos
54 f sporulation genes during vegetative growth in a manner that depends on c-di-GMP-mediated dimerizati
55 of PP6 to regulate Ssp2-T189 phosphorylation in a manner that depends on energy but not on the intact
56 ion and alter hypothalamic neuronal activity in a manner that depends on FA type and cellular transpo
57 s the release of SF3B1 from nuclear speckles in a manner that depends on FANCI and on the activity of
58 independently of its catalytic activity but in a manner that depends on interaction with the tetheri
60 in which D2Rs enhance cellular excitability in a manner that depends on synaptic input, is mediated
61 lves its retrotranslocation into the cytosol in a manner that depends on the AAA-ATPase p97/VCP [3].
63 ioural and physiological responses to stress in a manner that depends on the behavioural state of the
64 Sar1 alone is competent for vesicle scission in a manner that depends on the concentration of Sar1 mo
65 dium lowers cyclic-di-AMP levels and does so in a manner that depends on the gdpP phosphodiesterase g
66 egulate action potential (AP) repolarization in a manner that depends on the modulation of inactivati
67 zed with the polycation poly(allylamine HCl) in a manner that depends on the NOM-to-DNP concentration
68 ks shift their positions in the chromatogram in a manner that depends on the peak shape of the overlo
69 c reticulum stress and proteasome inhibition in a manner that depends on the source of porphyrin buil
70 presence of a second nucleosome changes chi in a manner that depends on the spacing between the two
71 ctivation modulates pore blockade by QA ions in a manner that depends on the state of the internal ac
73 omplex hyperacetylates histone tails in vivo in a manner that depends upon histone 3 lysine 4 trimeth
75 bilization of the GHSR1a-ss-arrestin complex in a manner that determines the ultimate cellular conseq
76 ulin to biomimetic "mitochondrial" membranes in a manner that differentiates between the two primary
78 ity of HIV-1- and SIV-infected cells to ADCC in a manner that directly correlates with elevated Env l
79 nm in length and envelopes the cluster core in a manner that discriminates between the reactivities
80 c deletion impaired alveolar differentiation in a manner that disrupted alveolar progenitor cell popu
81 ly organisational and financial constraints, in a manner that does not 'alienate' nurses and nurse ma
82 or variants with increased protein abundance in a manner that does not compromise catalytic activity,
84 isaggregase Hsp104 contributes to this delay in a manner that does not require its "unfoldase" activi
85 smission in the ventral tegmental area (VTA) in a manner that enhances dopaminergic signaling and pro
86 h SSB is shown to modulate SSB/DNA complexes in a manner that exposes a potential replication initiat
87 in mediates chaperone-substrate interactions in a manner that extends beyond recognition of a particu
88 enesis, this specificity transiently changes in a manner that facilitates genome packaging; nucleocap
89 , can influence the patterning of new tissue in a manner that facilitates integration with pre-existi
90 tion of utrophin disrupts domain composition in a manner that favours open channel area expansion, as
91 fers to act on strand invasion intermediates in a manner that favours strand invasion and exchange.
92 shion, dependent upon extracellular calcium, in a manner that followed peak cytosolic calcium levels
93 hether it is possible to reconnect a protein in a manner that generates a new topology yet preserves
94 nds in a S-shaped amyloid fold, and arranged in a manner that generates two hydrophobic cores that ar
95 asmic half-channel is more easily protonated in a manner that halts ATPase-driven rotation by blockin
96 allowed interrogation of the nuclear genome in a manner that has dramatically improved the diagnosis
97 tivity and specificity of EV labeling assays in a manner that has not been described for other EV det
99 roach that allows optogenetics to be applied in a manner that helps to avoid potential complications.
102 serves interaction with FANCJ constitutively in a manner that impedes proper chromatin localization o
103 ed that caspase-4 modulates microglial cells in a manner that increases proinflammatory processes.
104 in a control group to change their behavior in a manner that increases their risk, it is incumbent o
105 an anionic trypsinogen is controlled by CTRC in a manner that individual natural mutations are unlike
107 ardiac myocytes; however, only Hmgb2 does so in a manner that involves global reprogramming of chroma
108 NF169 binds to ubiquitylated H2A-Lys13/Lys15 in a manner that involves its canonical ubiquitin-bindin
109 it with its assembly into the COX enzyme and in a manner that involves the Cox14 and Coa3 proteins.
110 disrupt the organization of SCS macrophages in a manner that involves the migration of mature dendri
111 predispose subsequent generations to disease in a manner that involves the transgenerational inherita
112 therapy and immune status should be designed in a manner that is appropriate for a given cancer.
113 ritical junctures in the poxviral life cycle in a manner that is both dependent on and independent of
114 le substrates are largely absent, especially in a manner that is both scalable and well controlled.
115 w that 12Gso down-regulates Tbx18 expression in a manner that is both spatially- and temporally-speci
116 drives metabolic dysfunction in macrophages in a manner that is cell-autonomous and independent of i
118 binds RNA as a monomer, and that it does so in a manner that is commensurate with a canonical and pr
119 between halves of a ribbon within 1 minute in a manner that is consistent with a simple diffusion m
120 hain hydrogen-bonding potential is satisfied in a manner that is consistent with and stabilizes the b
121 es the intensity of the anti-Stokes emission in a manner that is consistent with electronic Raman sca
122 and quinine compete for transport via PfCRT in a manner that is consistent with mixed-type inhibitio
123 phylogeographic lineages vary geographically in a manner that is consistent with reproductive charact
124 tatus be evaluated, validated, and performed in a manner that is consistent with standard procedures
125 te of reaction depends upon solution acidity in a manner that is consistent with the formation of the
126 imensions allow nurses and physicians to act in a manner that is consistent with their professional e
127 ter collective terahertz dipole oscillations in a manner that is correlated with their anesthetic pot
128 rdinates the endocytic turnover of integrins in a manner that is crucially important for angiogenesis
129 preferentially catalyzes H3K4 dimethylation in a manner that is dependent on an unknown non-active-s
130 C5a and C3a suppress IFN-beta production in a manner that is dependent on Bruton's tyrosine kinas
131 nal modifications and nonprocessive cleavage in a manner that is dependent on elevated c-di-GMP level
132 the activity of individual prefrontal units in a manner that is dependent on hippocampal input only
133 ngation factor b (P-TEFb) from the 7SK snRNP in a manner that is dependent on its helicase activity,
134 ulates IL-33 expression in endothelial cells in a manner that is dependent on the DNA-binding protein
135 mic loci naturally found in the human genome in a manner that is dependent on the guide RNA sequences
136 addition, MamK-like forms filaments in vivo in a manner that is dependent on the presence of MamK an
137 ction of NEAT1 induces paraspeckle formation in a manner that is dependent upon both NEAT1 and on HIF
138 opore closure is delayed in elderly subjects in a manner that is dependent upon MN length, number, an
139 central pore of an asymmetric Vps4p hexamer in a manner that is dependent upon the presence of flexi
140 ole in balancing intracellular growth of Mtb in a manner that is directly responsive to host innate i
141 anti-gH antibodies can block gH/gL/UL128-131 in a manner that is distinct from that for gH/gL/gO.
142 one-dimensional quantum systems often behave in a manner that is distinctly different from their high
143 cat attenuates Wnt/beta-cat-responsive genes in a manner that is downstream of beta-cat/TCF loading o
144 long-term immunological memory is maintained in a manner that is even more dynamic than previously th
145 rrested at the non-permissive end of Tus-Ter in a manner that is explained by a composite mousetrap a
146 ticular, because choline and TMA bind to DNA in a manner that is found to be distinct from that previ
148 flammation and brain markers of neurogenesis in a manner that is highly reflective of ASD in humans.
149 DAMTS3 is required for lymphatic development in a manner that is identical to the requirement of VEGF
150 ated internalization from the B-cell surface in a manner that is independent of activation of FcgRIIb
151 urs with UV-mimetic chemical carcinogens and in a manner that is independent of DNA repair and severa
152 is required to restrain apical aPKC activity in a manner that is independent of endolysosomal traffic
153 at MCPyV sT enhances LT-mediated replication in a manner that is independent of its previously report
155 rterioles using resting intracellular Ca(2+) in a manner that is independent of phasic, neuronal-evok
156 nases or as a scaffold protein for signaling in a manner that is independent of phosphoryl transfer (
157 decreases the interaction of PP5 with ERK2, in a manner that is independent of PP5 and MAPK/ERK kina
159 rotein can control DNA synthesis and mitosis in a manner that is indistinguishable from wild type.
160 lifetime to probe absolute membrane voltage in a manner that is insensitive to the protein expressio
161 the pacemaker's phase-relationship to sleep in a manner that is known to cause switches from depress
163 ions indeed integrate with bottom-up signals in a manner that is modulated by the predictability of t
164 measurements in a high-throughput manner and in a manner that is more accessible to a broad community
167 tion lead to more dominant behaviour, albeit in a manner that is not statistically regulated by testo
168 Tot/[HSA]Tot ratio is reproducibly estimated in a manner that is only minimally sensitive to glycatio
169 s following transfer to wild-type recipients in a manner that is partially dependent on IL-2R and STA
170 ks are formed between the rims of CD and CB6 in a manner that is positively cooperative, giving rise
171 opo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that t
172 promoter DNA sequence can tune noise levels in a manner that is predictable and partly decoupled fro
173 i.e., to move in time with a perceived pulse in a manner that is predictive and flexible across a bro
174 owing acute i.p. challenge with LPS plus ATP in a manner that is proportional to the free/unbound con
175 adaptive immunity at remote mucosal surfaces in a manner that is protective against a variety of resp
176 occurs at nuclear and then cytoplasmic sites in a manner that is regulated by molecular chaperones an
177 ances of the cells expressing the biosensors in a manner that is related to the in vitro stabilities
178 romeric origins to promote early replication in a manner that is reminiscent of the recruitment of Db
179 enable them to contract and expand linearly, in a manner that is reminiscent of the sarcomeres of mus
180 lates thrombin-dependent platelet activation in a manner that is required for successful embryonic de
181 scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhi
182 ring infarct size in mice, rabbits, and pigs in a manner that is rigorous, accurate, and reproducible
183 ctedly, NmeCas9 cleaves single-stranded DNAs in a manner that is RNA guided but PAM and tracrRNA inde
184 neuroblastoma by the protein kinase Aurora-A in a manner that is sensitive to certain Aurora-A-select
185 transmission, ES programs must be developed in a manner that is sensitive, with sufficiently frequen
186 mical data, indicate that NtrC4 binds to DNA in a manner that is similar to that of its close homolog
187 in the processing of faces and vocalizations in a manner that is similar to the inferior frontal gyru
188 clade Argonaute proteins silence transposons in a manner that is strictly dependent on their sequence
189 sociated antigens (TAA) to the immune system in a manner that is sufficient to engender antitumor res
190 that this network of reactions can function in a manner that is superficially similar to the most ba
191 reveals the presence of activated microglia in a manner that is superior to (11)C-(R)-PK11195 due to
192 d purified Drp1 and increase GTPase activity in a manner that is synergistic with the mitochondrial p
193 rection of self-translation) from optic flow in a manner that is tolerant to rotational visual cues g
194 , represents pathways for movement in scenes in a manner that is tolerant to variability in other vis
196 we investigated whether BMP7 can modulate HA in a manner that leads to prevention/reversal of TGF-bet
197 100-250 Hz) sharp wave ripple (SWR) activity in a manner that likely drives synaptic plasticity and p
201 al aspects of RNA-mediated disease pathology in a manner that may be more beneficial than oligonucleo
202 poral properties of the neocortical response in a manner that may both refine and minimize cortical o
203 cognate HLA ligands can disarm KIR+ NK cells in a manner that may decrease HLA- tumor cell recognitio
204 mers may respond to this differential change in a manner that may fundamentally alter the energy path
205 d postprandial lipids in healthy individuals in a manner that may have an effect on the long-term dev
206 cated, or inserted can disrupt or fuse genes in a manner that might not be predicted by conventional
207 the decision but instead altered confidence in a manner that mimicked a change in visual motion, plu
208 le molecules undergoing rotational diffusion in a manner that mimics experimentally collected data of
209 ngs that twist under irradiation with light, in a manner that mimics how plant tendrils twist and tur
211 full infectious life cycle of C. trachomatis in a manner that mimics the infection of human blood-der
212 mal clusters determines the pattern of villi in a manner that mimics the spread of a self-organizing
213 ain the collective response of a metasurface in a manner that neglects the interactions between meta-
214 hromosomal arm changes and aneuploidy events in a manner that offers similar information as a traditi
216 talysis, suggesting that MD2 binds to MraYAA in a manner that overlaps with, but is distinct from, it
217 accumbens core (NAcC) uniquely expressed Fos in a manner that positively correlated with cocaine-seek
218 that the TCR docked over the A' roof of CD1a in a manner that precluded direct contact with permissiv
219 nd cortico-basal ganglia reward, circuitries in a manner that predisposes individuals to self-medicat
221 an modulate the proteolytic activity of SpeB in a manner that preserves the integrity of several othe
222 to compete and face their growing challenges in a manner that preserves their essential missions.
223 ws patients to receive multimodality therapy in a manner that prioritizes early exposure to systemic
224 100-250 Hz) sharp-wave ripple (SWR) activity in a manner that probably drives synaptic plasticity and
226 ciples for communicating scientific findings in a manner that promotes objectivity, public trust, and
227 on is CCR5-dependent and appears to function in a manner that promotes the translation of iNOS and CO
229 s modulated by spectrally directed attention in a manner that recapitulates its tonotopic sensory org
230 iffers between nocturnal and diurnal beetles in a manner that reflects their contrasting visual ecolo
231 s to compartments (e.g., urban, agriculture) in a manner that reflects their different patterns of us
232 gement in each of the four rhythmic circuits in a manner that related to successful performance of th
233 on-derived vibrational spectrum to red shift in a manner that reproduces the red-shift previously rep
234 oritized stimulus biases population activity in a manner that reproduces this empirical tradeoff in m
235 h blunt-ended DNA, Ku protected against Exo1 in a manner that required its DNA end-binding activity.
236 and branching in trigeminal ganglia neurons in a manner that required selective activation of transm
237 efficiently repaired without end processing, in a manner that required the kinase activity of DNA-PKc
238 ransduce signals through the TCR signalosome in a manner that requires Fyn activity and self-peptide-
240 be rapidly and posttranslationally activated in a manner that requires its transmembrane domain but n
241 protein by human peripheral blood monocytes in a manner that requires neither the presence of microb
242 ly, fibulin-3 promotes glioblastoma invasion in a manner that requires NF-kappaB activation both in t
243 ichiometrically to filament sides and severs in a manner that requires phosphate release from the fil
244 l GIRK channels containing the GIRK1 subunit in a manner that requires phosphatidylinositol-4,5-bisph
246 E17 (MPK17) in affecting peroxisome division in a manner that requires the known peroxisome division
247 Mek that blocks detachment-induced EGFR loss in a manner that requires the presence of a signaling pr
249 d SGs can be disassembled by HSV-2 infection in a manner that requires vhs endoribonuclease activity
250 ong structure when directing songs at pupils in a manner that resembled how humans alter their vocali
251 ferred to as MAb 3.1, recognizes its epitope in a manner that resembles recognition of a similar epit
253 bone interactions at open beta-strand edges, in a manner that resembles the inter-strand interactions
254 be offered at the right time, and delivered in a manner that respects, protects, and promotes human
255 esidues influence the cavity occupied by ST3 in a manner that results in favorable binding to GluN2A,
256 e, antigen or antibody) on a sensor surface, in a manner that retains a high degree of activity and l
257 fying nanoparticle adsorption thermodynamics in a manner that satisfies the assumptions of the Langmu
258 s that were transmitted to neighboring cells in a manner that scaled with agonist concentration.
259 gaps' between genes, circuits and behavior, in a manner that should help to translate the rapidly gr
260 ults, some individuals express this behavior in a manner that significantly increases their risk for
261 ough protein, pathway, or genome engineering in a manner that specifically alters the final OMV produ
264 The TMD of syx influences fusion pore flux in a manner that suggests it lines the nascent fusion po
266 e dorsal-ventral axis of the medial EC (mEC) in a manner that suggests this topographical organizatio
268 modified PsACS and PsACO transcript profiles in a manner that suppressed ovary ethylene evolution.
270 n disturbance overrode regional climate, but in a manner that varied across the Tension Zone Line.
271 tive cooperativity with each of the agonists in a manner that varied with the pathway investigated an
272 ivity from both motor and cognitive networks in a manner that varies with frequency, behavioral state
273 d inhibited inflammatory cytokine production in a manner that was abrogated by anti-PD-L1 blocking an
274 d the growth of irradiated tumor xenografts, in a manner that was associated with reduced HIF1alpha l
275 e expression both in mice and cultured cells in a manner that was at least in part independent of the
276 y increased cortically evoked spike activity in a manner that was blocked following intrastriatal inf
277 ate protein homeostasis and mRNA translation in a manner that was both rapamycin-sensitive (proteasom
278 grip1l expression in mice affected adiposity in a manner that was consistent with CUX1 influence on a
279 ely regulated neutrophil recruitment in vivo in a manner that was dependent on macrophage-produced CX
280 ulated ILC2s purified from mouse bone marrow in a manner that was dependent on signaling through the
282 ana promoted the degradation of chlorophyll, in a manner that was distinct from that shown by SGR.
283 aried nonlinearly with stimulus strength but in a manner that was independent of the cone of origin a
284 eletion suppressed small intestinal adenomas in a manner that was indistinguishable from germline Bmi
285 nized mallotoxin's channel-activating effect in a manner that was largely dependent on its own modula
286 y decreased by food deprivation in male mice in a manner that was partially reversed by the satiety-r
287 and species varied within and between cities in a manner that was predictable by geographic covariate
288 fluoxetine facilitated extinction retrieval in a manner that was prevented by systemic or BLA-specif
289 and possibly non-cell-autonomous mechanisms, in a manner that was reversed by dietary ascorbate.
290 arrier (BBB) and accelerated Abeta pathology in a manner that was reversible by endothelial PICALM re
291 outcomes at the time of feedback and did so in a manner that was stable over time, in contrast to pr
292 ely over-accumulated triacylglycerols (TAGs) in a manner that was synergistic with other TAG inducing
294 ity: the primary auditory cortex reorganized in a manner that was unusually "tuned-in" to the specifi
295 ients the RBD-RBD interface extensively, and in a manner that will enhance solvent exposure of the FA
296 help physicians prescribe hydroxychloroquine in a manner that will minimize the likelihood of vision
297 roperties are altered in the disease process in a manner that would be detrimental for NMJ repair.
299 n modulating SpeB expression and/or activity in a manner that would potentiate bacterial virulence.
300 ands on simple linear receptive field models in a manner that yields substantially improved predictiv
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