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3 urn mimics simulating varied beta-turn types in place of 2 residues in an engineered beta-turn 1 or b
4 ation, alanine substitutions were engineered in place of 28 charged residues residing in the N- and C
11 c suppressor mutant log1-1, with an arginine in place of a conserved glycine, failed to interact in t
13 ts from an unconventional residue, Leu(222), in place of a conserved proline in transmembrane domain
15 incorporation of both unnatural amino acids in place of a phenylalanine in the hydrophobic core of T
17 with an Ancestral Recombination Graph (ARG) in place of a simple tree, which presents significant co
19 ed by two DRPs, MFN1 and MFN2, that function in place of a single outer membrane DRP, Fzo1 in yeast.
20 The impact of using a high-efficiency X-cone in place of a standard H-cone with the MCN and Apex was
23 ames, including an IS30-like DDE transposase in place of a Tyr/Ser recombinase and homologs of gram-p
25 richia coli (LacY) with a single-Cys residue in place of A122 (helix IV) transports galactopyranoside
26 values spanning the observed range) are used in place of actual tree-ring delta(13)C measurements.
27 ansformation is also compatible with allenes in place of alkynes to furnish tetrasubstituted alkenyl
28 ls can be substituted by using wood products in place of alternative materials and energy, but wood h
29 ffects than amphotericin, and is widely used in place of amphotericin; however, clinical trials compa
32 gene and a variety of Dbeta or Jbeta genes, in place of an intact TCRbeta-chain and in association w
34 using a targeting probe for cell procurement in place of an operator-based, cell-by-cell selection pr
36 moxifen 20 mg per day (with matching placebo in place of anastrozole) or oral anastrozole 1 mg per da
37 y curves are recalculated with methyl groups in place of anilino protons, the barrier to isomerizatio
39 d by incorporation of an amphiphilic peptide in place of apolipoprotein A-I as the lipid emulsifier a
41 ging between two speech sounds that differed in place of articulation, in that the vocal tract is ope
43 apy approach combining low-dose rivaroxaban (in place of aspirin) with a P2Y12 inhibitor has not been
45 te kinetic analysis using a 3'-dATP analogue in place of ATP shows that removal of this distal intera
47 cipients (n = 5) were treated with alefacept in place of basiliximab, and more intense LFA-1 blockade
51 evelop core isosteres by inserting B-N units in place of C horizontal lineC bonds within aromatic sca
55 is, mice were created that express mCD40LMP1 in place of CD40, and are either sufficient or deficient
56 e find that a Tg-AChE chimera (swapping AChE in place of ChEL) allows for dimerization with monomeric
57 oligosaccharide fragment of PNAG, 9GlcNH(2), in place of chemically partially deacetylated PNAG, thre
61 ased use of natural gas in the power sector, in place of coal-fired power generation, drove reduction
62 many reports in literature in using aptamers in place of conventional antibodies as capture biomolecu
63 ther network-based strategies should be used in place of conventional field approaches to target indi
64 ion of artificially structured metamaterials in place of conventional materials for improving optical
76 Here we show that substituting polyamines in place of elemental counterions significantly enhanced
78 le would facilitate individualized treatment in place of empirical treatment, improve treatment outco
81 HCV RNAs encoding GBV-B structural proteins in place of equivalent HCV sequences designed to allow e
84 oclasts use actin-rich attachment structures in place of focal adhesions for adherence to bone and no
86 le evidence strongly supports the use of CMA in place of G-banded karyotyping as the first-tier cytog
88 on)-acyl group, (2) the presence of d-IsoGln in place of gamma-d-Glu, and (3) the presence or absence
89 t one optically flat surface and can be used in place of glass microscope slides as sample substrates
90 line at position 6, 4-cyanoaminobutyric acid in place of Glu13, beta(3)-homoarginine at the position
92 ecA ortholog and contains histidine (His195) in place of glutamine at the allosteric switch position.
93 nerated a GS mutant that catalyzes azido-Ala in place of Gly with high catalytic efficiency and selec
94 ained sarcosine and aminocyclopropanoic acid in place of Gly5, D-valine at position 6, 4-cyanoaminobu
96 astline, requiring use of lower sulfur fuels in place of heavy fuel oil in main engines of ships.
98 e firefly luciferase (Luc) gene was inserted in place of HSP70 as a control for the double insertion.
103 of the P450 enzyme CYP119 containing iridium in place of iron catalyze insertions of carbenes into C-
104 und that manganese can activate Rpe in vitro in place of iron, converting the enzyme to a form that i
109 sults in the accumulation of Kdo-lipid IV(A) in place of lipid IV(A) without suppression of its growt
110 such as alkyl azides and photo-cross-linkers in place of lipoic acid, facilitating imaging and proteo
111 needed such that these proteins may be used in place of liver biopsy to facilitate diagnosis and tre
113 n to use Plasmodium falciparum parasite rate in place of malaria index in the modelling of malaria de
114 l using modification with gold nanoparticles in place of matrix in this application showing its poten
115 sed for peroxidase activity with water bound in place of Met80, which serves as the axial heme ligand
118 n MHV68 virus that encodes KSHV LANA (kLANA) in place of MHV68 LANA (mLANA) and evaluated the virus's
120 findings do not support the use of cisplatin in place of mitomycin in combination with fluorouracil a
121 ive nitrogenases, which use vanadium or iron in place of molybdenum at their active site, might play
122 olutions that use weakly coordinating anions in place of more nucleophilic traditional electrolyte an
123 enated dioxins and furans that could be used in place of more traditional gas chromatography coupled
127 (GLP-1) containing beta-amino acid residues in place of native alpha residues at selected sites and
131 hosphatidylcholine (PC) has been widely used in place of naturally occurring phosphatidylethanolamine
135 propylphenyl)imidazolidin-2-ylidene) is used in place of Ni(COD)2/SIPr.HBF4/KO(t)Bu (COD = 1,5-cycloo
138 TNF)-alpha antagonists are increasingly used in place of nonbiologic comparator medications, their sa
139 ant viruses expressing these mutant proteins in place of normal A33 had a small-plaque phenotype.
141 d RNA (dsRNA)-dependent protein kinase (PKR) in place of NSs, were protected from wild-type (wt) RVFV
142 titution of aliovalent N(3-) and F(-) anions in place of O(2-) in ZnO brings about major changes in t
143 , recombinant viruses expressing O3 homologs in place of O3 replicated and formed plaques as well or
145 splatin derivative containing phenanthridine in place of one of the chloride ligands, forms highly po
150 escent protein fused in frame with P (PeGFP) in place of P and a fusion matrix protein (monomeric red
151 -MeqGCN) containing the chimeric meqGCN gene in place of parental meq was generated with overlapping
153 e overcome by introducing exchangeable links in place of permanent network crosslinks, a concept prev
155 The derivative 1 containing hbeta(3) Phe in place of Phe showed good mu- and delta-receptor affin
156 zolophanes that incorporate pyridyl subunits in place of phenylenes show a heightened propensity to f
157 e to accept templates with triazole linkages in place of phosphodiesters, we have designed a strategy
160 calcified CaM N lobe interacts with helix B in place of PIP2 to limit excessive IKS current inhibiti
161 ation, making it feasible to use minicircles in place of plasmids in mammalian transgene expression s
162 ssentially we use 3' UTR sequence similarity in place of population cryptic relatedness in the GWAS p
163 fied a novel glycosylation site with alanine in place of proline, suggesting a revised, broader conse
167 ld be a lead for development of drugs to use in place of recombinant human TSH in patients with thyro
168 etion strains containing unique DNA barcodes in place of regulator genes were mixed with the parental
169 NA-binding region, or poly-Ala substitutions in place of residues 148-HQDVR-152 (beta(148-152)), affe
174 sing a phospho-mimetic aspartic acid residue in place of serine at position 193 (S193D) of C/EBPalpha
175 djusted for urinary albumin:creatinine ratio in place of serum creatinine (P=0.005 for sTNF-R1 and P=
176 s with two yeast I-SceI endonuclease targets in place of Sgamma1 undergo I-SceI-dependent class switc
177 M), which uses iterative image deconvolution in place of single- or multiemitter localization to esti
178 etically encoding N-varepsilon-acetyl-lysine in place of six lysine residues in histone H3 enables de
179 mal microarray analysis as a first-tier test in place of standard karyotype for the evaluation of fet
182 recovered viruses with alanine substitutions in place of SWWS residues had second-site, partially com
184 (RNAi) resulted in the regeneration of heads in place of tails, a phenotype previously observed with
187 t, we found that TNA replication using tCfTP in place of tCTP exhibits 98.4% overall fidelity for the
189 alyze hydroxylation reactions using H(2)O(2) in place of tetrahydropterin and oxygen, forming tyrosin
190 mily, that have evolved a tryptophan residue in place of the (D/E) in the second conserved motif; the
192 otide substrate that contained a sulfur atom in place of the 3'-bridging oxygen of the scissile phosp
193 d, NT-9-21, which contains dichloro moieties in place of the 3,5-dibromo substituents of NT-7-16, had
196 y histidine is used as an acid/base catalyst in place of the anionic glutamate seen in other GH3 fami
197 systemic lupus erythematosus, are appearing in place of the antihistone antibodies, typically found
198 otion (TPM) but employs a single fluorophore in place of the bead, allowing TFM to be combined with e
199 e of the unidirectional C31 integrase system in place of the bidirectional Cre recombinase reaction;
203 e of the SH2 domain of Csk is the tight turn in place of the canonical CD loop in a surface site far
205 -determining region 3-delta (CDR3delta) loop in place of the CDR3alpha loop of an alphabeta TCR.
206 helices that feature a carbon-carbon linkage in place of the characteristic N-terminal main-chain hyd
207 lls that can be used for tissue regeneration in place of the controversial human embryonic stem cells
208 ng a 2-isopropoxy-3-phenylbenzylidene ligand in place of the conventional 2-isopropoxybenzylidene lig
209 hus, our saw-shaped geometry gate potential (in place of the conventional bar-shaped geometry) leads
214 ts expressing a deregulated bacterial AGPase in place of the endogenous AGPase and in plants containi
222 g an iridium porphyrin cofactor (Ir(Me)-PIX) in place of the heme catalyze enantioselective intramole
223 second and third generation Grubbs catalysts in place of the HG2 catalyst for the polymerization of A
225 immediate early promoter into the VC2 vector in place of the HSV-1 thymidine kinase (UL23) gene.
226 ]octan-3-one but contains a tert-butyl group in place of the hydroazulene subunit of MacE, was prepar
227 1 (bel1) mutants produce aberrant structures in place of the integuments and WUS is ectopically expre
228 ysine instead of the usual carboxyl group is in place of the internal proton donor to the retinal Sch
229 ed (MgK) or native (NgK) form of the gK gene in place of the latency-associated transcript with a myc
230 imerizing the fused sdAbs, imparting avidity in place of the lower affinity monomeric interactions.
232 A hypothetical flat plain at 3500 m depth in place of the MAR would contain 85.6 kt C, implying an
236 cin B phosphotransferase (HPT) gene cassette in place of the module 4 sequence in aba1 resulted in a
237 ns reveals that the use of formic acid (1%), in place of the more commonly used perchloric acid, comb
238 c position of the Leavenworthia S locus, and in place of the more typical Lal2 and SCRL sequences.
239 potently antagonized by molecules that bind in place of the native acylated homoserine lactone autoi
242 to S variant enzyme forms quinolacetic acid in place of the native product 2,5-dihydroxyphenylacetic
243 rmal or chemical inactivation are often used in place of the native toxin; however, the process of de
245 alphavbeta6, which allowed a virus with KGE in place of the normal RGD integrin-binding motif to use
246 Here we utilized Ca(2+) ions and sulfur in place of the nucleophilic oxygen in a 20-residue pseu
248 4-aminocyclohexane-1-carboxylic acid moiety in place of the pentapeptidic tail, was identified as a
251 gradient spin-echo NMR spectroscopy was used in place of the previous method of Gouy interferometry t
252 hreonine can be misincorporated into protein in place of the proteinogenic amino acid threonine.
255 utilizing the polymer capture matrix method in place of the solid-phase extraction method is that th
257 hods can advance knowledge alongside or even in place of the standard hypothesis-driven approach, whi
258 ne, 2,6-Diaminopurine or Iso-deoxyGuanosine) in place of the standard T, C, A or G to avoid mismatch
260 d an alternative vaccine which could be used in place of the traditional live attenuated RPV strains,
261 aining one or two longer hydroxy fatty acids in place of the usual R-3-hydroxymyristate at positions
262 icons containing the Gaussia luciferase gene in place of the viral ORF2 or ORF3 genes demonstrated th
263 es expressing Ebolavirus glycoproteins (GPs) in place of the VSV G protein demonstrated protection of
267 nin-like envelope glycoproteins HL17 or HL18 in place of the VSV glycoprotein were generated to ident
268 , which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% effica
270 fibroblasts; the use of phosphomutant Ascl1 in place of the wild-type protein significantly promotes
271 mosquito-borne flaviviruses were substituted in place of the WNV EIII were recovered, although the su
273 rt either the use of a month of IV HDI alone in place of the year-long regimen or the initiation of a
276 mutant carrying a phosphomimetic Glu residue in place of Thr-170 loses TRIM25 binding, Lys-172 ubiqui
277 ilin mutants that have alanine substitutions in place of threonine in the LPXTG motif or lysine in th
278 dimethylaminopropargyl deoxyuridine (DMAPdU) in place of thymidine and examined their ability to form
279 caused by excess misincorporation of uracil in place of thymidine combined with a defect in the urac
280 o single molecule array (Simoa)-based assays in place of traditional detection antibodies for six cyt
281 (AuNPs), utilizing DNA linkers and diluents in place of traditional self-assembled monolayers, is re
282 e" assay which includes polyvinylpyrrolidone in place of traditional surfactants-improving sensitivit
283 Alternative electrophiles can also be used in place of trifluoromethylsulfonium reagents to effect
284 e of omega-N-methyltryptamine and tryptophol in place of tryptamine led to the enzymatic synthesis of
285 droxyproline dehydrogenase, which has serine in place of tyrosine at this key active site position.
286 f ritonavir-boosted protease inhibitors (PI) in place of unboosted PIs has made the selection of PI r
290 ant or an MCPyV-origin mutant was introduced in place of wild-type LT or wild-type viral origin.
292 ne (NO(2)Y, pK(a) 7.1) has been incorporated in place of Y(122), Y(731), and Y(730) to probe how the
293 Y (F(3)Y) was site-specifically incorporated in place of Y(356) in beta2 and 3-NH(2)Y (NH(2)Y) in pla
296 Y (3,5; 2,3; 2,3,5; and 2,3,6) incorporation in place of Y122-beta and the X-ray structures of each r
297 otyrosine was site-specifically incorporated in place of Y356-beta, Y731- and Y730-alpha, and each pr
298 When 3-aminotyrosine (NH2Y) is incorporated in place of Y730, a long-lived NH2Y730* is generated in
300 yl-2, 6-dioxocyclohex-1-ylidene) ethyl (Dde) in place of Z protection on the amino alcohol has allowe
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