ライフサイエンスコーパス: in the course of

1 In the course of 10 years, the doses of the drugs used f

2 mg (13)C-EPA and its metabolism was followed in the course of 14 d in the plasma and 28 d in the brea

3 have been proposed as reactive intermediates in the course of [2 + 2 + 2] annulation reactions.

4 c diversification of hepatitis C virus (HCV) in the course of 200 passages in human hepatoma cells in

5 onto collagen type I and type III membranes in the course of 4 weeks.

6 idual performance variations as large as 26% in the course of a day.

7 In the course of a genome-wide analysis of members of a

8 In the course of a GRK2 structure-based drug design camp

9 ed extensive acute nasal skin necrosis early in the course of a life-threatening illness characterize

10 In the course of a more chronic viral infection, mice va

11 Cancer-induced muscle wasting begins early in the course of a patient's malignant disease, resultin

12 In the course of a search for new classes of hydrogen bo

13 e human hippocampus subserves both functions in the course of a single event.

14 ation of topological defects-winding numbers-in the course of a superconducting transition in a stron

15 Graph-theoretic analysis revealed that, in the course of a trial, the balance between sensorimot

16 inform the need to adjust these alternatives in the course of action based on continuously acquired m

17 ular protease activation, an initiating step in the course of acute pancreatitis.

18 red by continuous intravenous infusion early in the course of acute respiratory distress syndrome for

19 ons for the small Rho GTPases Cdc42 and Rac1 in the course of adult hippocampal neurogenesis.

20 autoantibody profile does not markedly vary in the course of AIH.

21 regulatory phenotype appears as a key event in the course of AIT and normal immune response to aller

22 Late allergic reactions are common in the course of allergen-specific immunotherapy and eve

23 ay matter neurodegeneration and amyloid load in the course of Alzheimer disease (AD) are poorly under

24 g (API) detects amyloid-beta pathology early in the course of Alzheimer's disease (AD) with high sens

25 ause its microtubule interaction is impaired in the course of Alzheimer's disease and several other n

26 t of amyloid retention on functional changes in the course of Alzheimer's disease progression.

27 opeptin is secreted from the pituitary early in the course of AMI.

28 e (PC) among children presenting with a rash in the course of amoxicillin treatment are currently unk

29 roach this question, RNA content was altered in the course of amplification of hamster strains in ser

30 t a problem if undesired dissociation occurs in the course of an experiment.

31 In the course of an investigation of the reactions of ph

32 nt actions in response to information gained in the course of an outbreak can change the optimal init

33 nt information regarding vessel wall biology in the course of aneurysm development.

34 nflammation and scarrying of the spinal cord in the course of ankylosing spondylitis, present in MRI

35 in cholesterol (LDL-C) lowering occurs early in the course of atherosclerosis or when very aggressive

36 In the course of autoimmunity studies, we identified the

37 In the course of avian evolution, the lambdamax of the m

38 orticosteroids if application occurs earlier in the course of bacterial corneal ulcers.

39 series of MR spectroscopy (MRS) examinations in the course of BBE.

40 om each center as well as participants early in the course of BD showed larger right inferior frontal

41 ified markers in 19 young participants early in the course of BD, 29 subjects with substantial burden

42 ntions, such as group psychoeducation, early in the course of bipolar disorder might have important b

43 endosome/lysosome pathway is disrupted early in the course of both Alzheimer's disease (AD) and Down

44 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction.

45 ld-type enzyme is protonated or unprotonated in the course of catalysis at neutral pH.

46 It was emphasized that in the course of catalysis various Pd-intermediates (inc

47 mmunological tumor control by CD4(+) T cells in the course of CD137 (4-1BB) agonist immunotherapy in

48 e remaining cell adhesion from the substrate in the course of cell crawling.

49 enosine (HAPR) may be generated endogenously in the course of cell metabolism by cytochrome P450, by

50 Changes in the course of cerebral venous thrombosis are less com

51 ly shown to contribute to joint inflammation in the course of CHIKV infection in mice.

52 ECM1 is induced in the course of chondrogenesis and its expression in ch

53 derived suppressor cells, which are elevated in the course of chronic inflammation, are responsible f

54 is known about the role of physical activity in the course of chronic obstructive pulmonary disease (

55 equest of the individual treating physicians in the course of clinical care for the purpose of making

56 uire a rapid and accurate diagnosis as early in the course of clinical disease as possible.

57 The detection of DENV RNA late in the course of clinical illness should serve to length

58 ls have potential to attenuate axonal damage in the course of CNS injury in trauma, inflammation, or

59 during spermatogenesis or male fetuses early in the course of conception/pregnancy.

60 In the course of conducting a series of studies whose go

61 lectivity at the ligand-binding stage and/or in the course of conformational changes required for tra

62 We propose that in the course of CRISPR interference Cas3 generates frag

63 sessment of pathologic ileal vascularization in the course of Crohn's disease.

64 visualize the cancerization field very early in the course of cutaneous carcinogenesis and provides i

65 Bronchiectasis develops early in the course of cystic fibrosis, being detectable in in

66 The data provide evidence that even early in the course of depression brain regions involved in mo

67 Changes in the course of depressive or anxiety disorder characte

68 In the course of detecting nuclear transcription factors

69 In the course of determining this folding pathway, we es

70 In the course of developing an enantioselective, Lewis b

71 This basic understanding is refined in the course of development.

72 number variant affects brain structure early in the course of development.SIGNIFICANCE STATEMENT Prob

73 kground of protein synthesis inhibition, but in the course of diapause, a state of dormancy and incre

74 ells, and that were differentially expressed in the course of differentiation.

75 In the course of digestion, the loss of anthocyanins was

76 the correlated evolution of these properties in the course of directed stem cells differentiation has

77 ciently deal with the current wealth of data.In the course of discussing results and experiences from

78 ne responses could contribute to differences in the course of disease or treatment response.

79 ighest risk for transmitting the virus later in the course of disease progression.

80 e identification of treatment response early in the course of disease would be useful to improve mana

81 In this study, we demonstrate that early in the course of disease, the kinetics of epidermal expr

82 tegrity of SD OCT retinal bands at onset and in the course of disease, time required to achieve each

83 prior to fibrillar Abeta accumulation early in the course of disease.

84 oidzation and this trend is further enhanced in the course of domestication and evolution of polyploi

85 in practice to recognize these factors early in the course of donor evaluation to improve the efficie

86 ure complete and reproducible transformation in the course of each memory cycle.

87 f neutrophil granulocytes in the spinal cord in the course of EAE, accompanied by elevated levels of

88 ic-active MS lesions and in the inflamed CNS in the course of EAE.

89 r, how the brain decides when to have breaks in the course of effort production remains poorly unders

90 phene sheets help maintain the capacity even in the course of electrochemical sintering.

91 osynthesis pathway was significantly altered in the course of elevated CO2 treatment.

92 secutive remodeling of the organelle surface in the course of endosomal maturation.

93 ppens and how well it can be predicted early in the course of epilepsy could be valuable in helping f

94 an important modification that has occurred in the course of erythroid evolution.

95 in one patient, who was treated for it early in the course of EVD.

96 network areas than macaques, indicating that in the course of evolution the human attention system ha

97 at the AP-2 complex of dikarya has acquired, in the course of evolution, a specialized clathrin-indep

98 In the course of evolution, eusociality has appeared sev

99 However, in the course of evolution, functional diversification l

100 ial protein import is functionally conserved in the course of evolution, many organisms seem to lack

101 suggesting that they could have been sampled in the course of evolution.

102 organs and their functional diversification in the course of evolution.

103 In the course of experiments examining protein interacti

104 In the course of exploring the scope of catalase-related

105 etal organization and axon-axon interactions in the course of familial amyloidotic polyneuropathy.

106 Therapies which are effective early in the course of FCAVD, however, are not necessarily eff

107 health because of ZIKV's neurotropic effects in the course of fetal development.

108 tivity of specific motoneurons was performed in the course of fictive crawling (crawling).

109 All SIRs decreased steeply in the course of follow-up time.

110 ces have arisen repeatedly and independently in the course of forkhead evolution.

111 lar and structural abnormalities begin early in the course of Fuchs' dystrophy, before the onset of c

112 egislation, but which also must be addressed in the course of genetic counseling.

113 In the course of genomic events that delete TSGs, a larg

114 cataract patients was significantly altered in the course of glaucoma.

115 the SH produces trace amounts of superoxide in the course of H2-driven NAD(+) reduction in the prese

116 or the first time a key role for these cells in the course of HCV infection.

117 stion of the 80 kDa glycoprotein transferrin in the course of HDX MS experiments is carried out using

118 ter using probiotics containing lactobacilli in the course of her treatment of Clostridium difficile

119 Here, we report that, early in the course of high-fat diet (HFD) feeding and obesity

120 gs support baseline resistance testing early in the course of HIV infection to guide ART selection am

121 o initiate a potent IFN-alpha response early in the course of HIV mucosal invasion in time to termina

122 iNOS(+) PCs are induced in the course of human H. pylori infection, and their ab

123 In the course of identifying substrates of individual PM

124 Furthermore, in the course of identifying this motif, novel wild-type

125 with end-of-life care, with no role earlier in the course of ILD, has created a culture of neglect.

126 Such formulations should be offered earlier in the course of illness.

127 the illness that are relatively stable early in the course of illness.

128 undergo extraordinarily rapid cell division in the course of immune responses.

129 in-general processes of associative learning in the course of individual development, and, although t

130 ty, the sooner IV metoprolol is administered in the course of infarction, the smaller the infarct and

131 ically enhanced in infected cells, increased in the course of infection and were diminished on siRNA-

132 s the infection may have been caught earlier in the course of infection, also showed no T or NK cell

133 Early in the course of infection, detection of pathogen-associ

134 Even late in the course of infection, parental viruses were not ec

135 an decreased expression of interferons early in the course of infection.

136 Colonization of the gut is a critical step in the course of infection.

137 al loss of intestinal barrier function early in the course of infection.

138 olates, indicating an important role for gGT in the course of infection.

139 trates that alpha1,3GT activity plays a role in the course of infections for certain viruses.

140 d steatosis, leading in one to liver failure in the course of infections.

141 onal cholinergic system, which is stimulated in the course of inflammatory processes.

142 RNAs may take place during the nuclear phase in the course of interaction of pUL47, VHS-RNase, and na

143 hosphorus recovery from municipal wastewater in the course of its treatment.

144 atural products generated from the cell wall in the course of its turnover.

145 was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in hum

146 In the course of long-duration diabetes mellitus during

147 tive variance can be responsible for changes in the course of long-term evolution.

148 re inhibited only if IL-10 is included early in the course of LPS stimulation and is strongly enriche

149 s occurred significantly (P < 0.001) earlier in the course of macrophage infection.

150 verse process that occurs relatively rapidly in the course of macrophage infection.

151 often necessary and should be started early in the course of management.

152 or the pathologic changes demonstrated by CM in the course of MCD.

153 sion of many key splicing regulators changed in the course of meiosis, including downregulation of po

154 Fate mapping confirmed that in the course of mesial temporal lobe epilepsy with scle

155 In the course of metformin treatment, staging abdominal

156 In the course of method optimization, the complementary

157 f the RPs (open circuit potentials) observed in the course of monitoring are significantly different

158 In the course of morphogenesis, tissues change shape and

159 blished a hypothesis whereby the variability in the course of MS is driven by the very same pathogeni

160 g the pia mater and subpial cord occur early in the course of multiple sclerosis and are more marked

161 Remarkably, in the course of muscle differentiation, nuclear movemen

162 ciples that have been proposed to be favored in the course of natural selection and development.

163 The influence of sertraline in the course of neuropsychological variables was not de

164 transcriptome of distinct ectodermal domains in the course of neurulation, during the establishment o

165 NMIIB relative to NMIIA is established later in the course of NMII turnover.

166 nctional changes in the kidney develop early in the course of obesity and occur independently of hype

167 demonstrates a dual role of B7 costimulation in the course of obesity-related sequelae, particularly

168 function, mice in whom talin is deleted late in the course of osteoclastogenesis are substantially pr

169 In the course of our analysis of the BMP signaling pathw

170 plain how false memories can arise naturally in the course of our daily lives.

171 In the course of our research in the agrochemical area,

172 In the course of our studies of HMO-microbial interactio

173 In the course of our studies toward the development of n

174 In the course of our studies, we have gained detailed in

175 t results of the process of rediploidization in the course of paddlefish genome evolution.

176 ough pathologic calcium signaling very early in the course of pancreatic injury.

177 e novel target for therapeutic interventions in the course of pathological cartilage injury.

178 dictive states are adjusted to fit the world in the course of perception, but in the case of action,

179 A20 as a novel downstream signaling molecule in the course of periodontal inflammation.

180 rate (2S,3S)-2-methyl-3-hydroxyacyl products in the course of polyketide biosynthesis.

181 tly drive plasma membrane protrusion, either in the course of polymerization or motor-driven sliding.

182 ucose metabolism increases before decreasing in the course of preclinical AD.

183 y phase followed by a hypoconnectivity phase in the course of preclinical AD.SIGNIFICANCE STATEMENT T

184 In the course of preparing microarrays to include probes

185 hing schizophrenia from mood disorders early in the course of psychosis.

186 ttern of abnormal brain neurochemistry early in the course of psychosis.

187 c resonance imaging (rs-fMRI) activity early in the course of psychosis.

188 ting Gal-3 concentrations are elevated early in the course of pulmonary fibrosis.

189 of connective tissue, i.e., scar formation, in the course of reactive and reparative processes.

190 nal pigment epitheliitis (ARPE) at onset and in the course of recovery by serial spectral-domain opti

191 Cardiovascular disease begins early in the course of renal decline and is a life-limiting pr

192 le, pathogenic variants in BRCA1) identified in the course of research.

193 er time in diabetic subjects before or early in the course of retinopathy.

194 in similar or different brain regions early in the course of schizophrenia, before antipsychotic tre

195 In the course of screening monoclonal antibodies (MAbs)

196 beta-strand peptide conformations form early in the course of self-assembly and that oligomers and fi

197 s in wild and captive chimpanzee communities in the course of several respiratory disease outbreaks.

198 re studies are needed to identify the timing in the course of SS when these different autoantibodies

199 d secretory protein (PSP), which occur early in the course of SS.

200 (i.e., to the change of boundary conditions in the course of stretching).

201 In the course of studying actin binding proteins that re

202 In the course of studying cancer-associated extracellula

203 In the course of studying the mechanism of thearubigin f

204 In the course of studying the role of Rrn3 in recruitmen

205 the subcellular redistribution of ceramides in the course of T cell activation.

206 Because of the wide variation in the course of Takayasu arteritis (TA), predicting out

207 n promoters of proinflammatory genes in vivo in the course of taurocholate-induced necrotizing pancre

208 In the course of that effort, a large cadre of new and p

209 li genes accumulated over 40 000 generations in the course of the 'long-term evolution experiment'.

210 copy (COSY) spectra are recorded every 3 min in the course of the 80 min reaction, leading to the una

211 as well as antigen immunofiltration directly in the course of the assay.

212 are discussed based on further data obtained in the course of the attempted syntheses of two addition

213 tion of oxygen vacancies on the TiO2 surface in the course of the CO oxidation.

214 In the course of the collaboration, primary data and ana

215 In the course of the development of WLTP, the Joint Rese

216 hus, PGCs can give rise to pluripotent cells in the course of the developmental cycle, during teratoc

217 In the course of the discovery of novel benzoxepin PI3K

218 sion) were less frequent, but appeared later in the course of the disease (6% and 12% before vs 64% a

219 assessment of blinatumomab treatment earlier in the course of the disease and in combination with oth

220 d BD, and that these changes may occur early in the course of the disease as a consequence of oxidati

221 ssive, large cell lymphoma, a critical event in the course of the disease associated with increased l

222 also present in AD, often manifesting early in the course of the disease before the accumulation of

223 18)F-FDG uptake increased in the bone marrow in the course of the disease, correlating with an increa

224 o present the results of subsequent MR scans in the course of the disease, so far described only in i

225 o quantify radiological inflammatory changes in the course of the disease, Stoke Ankylosing spondylit

226 e cell lymphoma (MCL) is low and occurs late in the course of the disease.

227 digm focused on curing atherosclerosis early in the course of the disease.

228 determined the onset of these abnormalities in the course of the disease.

229 pment of compartment-specific programs later in the course of the disease.

230 plugging and many other disorders that occur in the course of the disease.

231 iovascular health in patients with OCD early in the course of the disorder.

232 ture of white matter in these circuits early in the course of the disorder.

233 the substantial increase in entropy observed in the course of the ECT, hydrogen-deuterium exchange ma

234 in fish, suggests that this enhancer emerged in the course of the fin-to-limb transition.

235 gns for anthropogenic radionuclides released in the course of the Fukushima nuclear accident (2011),

236 d the contribution of readsorption phenomena in the course of the gastric digestion.

237 eting behavior is critical, especially early in the course of the illness, before it has become ingra

238 ocene megafauna extinction, which took place in the course of the last glacial.

239 In the course of the last two and a half decades, import

240 nthesis of IL-4, IL-5, and IL-13 by T cells, in the course of the mixed lymphocyte reaction (MLR).

241 oduction of IL-13, IL-4, and IL-5 by T cells in the course of the MLR, was further enhanced when DC w

242 Non-CNS infections were more frequent later in the course of the outbreak (median interval from last

243 In the course of the paper, we first introduce graphene,

244 ield test, higher baseline startle responses in the course of the prepulse inhibition test, and lower

245 There were no appreciable differences in the course of the primary EBV infections across treat

246 l intramolecular triplet-singlet conversions in the course of the process under consideration.

247 in which the contact ion pair is maintained in the course of the reaction.

248 ate Calpha hydrogen to the molybdenum center in the course of the reaction.

249 wo equiv of hydrogen and water are liberated in the course of the reactions.

250 re, no nuisance waste products are generated in the course of the reactions.

251 use of 6psigma delocalization, of Pt-P bonds in the course of the two reductions.

252 patients with or at high risk of ARDS early in the course of the underlying illness, when strategies

253 r younger, less obese patients who are early in the course of their cardiometabolic disease.

254 osis, and 20%-25% will develop these lesions in the course of their disease.

255 ients become resistant to these agents early in the course of their disease.

256 ent and impaired cognitive development early in the course of their epilepsy.

257 ns have adapted to novel climatic conditions in the course of their expansion.

258 Autophagosomes form in a de novo manner and, in the course of their formation, isolate cargo material

259 e (SITA) 10-2 automated visual field testing in the course of their management.

260 h results and incidental findings discovered in the course of their research and meeting an actionabi

261 index scores and sedative requirements early in the course of therapeutic hypothermia improve the ide

262 ging data, obtained at two time points early in the course of therapy (before initiation and followin

263 Early in the course of therapy a decrease in the expression of

264 etherapeutic PET/CT as well as changes early in the course of therapy and after therapy were compared

265 tions, may actually drive pathogenesis early in the course of these diseases.

266 In the course of these efforts, a series of novel SK1, S

267 In the course of these investigations, a dimeric Pd(II)-

268 In the course of these operations, there is an opportuni

269 elucidate the formation of ethyl carbamates in the course of these procedures.

270 In the course of this analysis, highly conserved protein

271 mplex organometallic intermediates generated in the course of this coupling process and document here

272 stinguish responders vs. nonresponders early in the course of this expensive and potentially toxic fo

273 In the course of this investigation, it was found that c

274 as a spiritual healer for several years and, in the course of this occupation, increasingly developed

275 Several unusual reactions encountered in the course of this study are thoroughly discussed.

276 In the course of this study we discovered that the numbe

277 In the course of this study, a highly efficient syntheti

278 In the course of this study, in population-based cross-s

279 In the course of this study, it became evident that sing

280 In the course of this study, we also observed that 2-O-a

281 In the course of this study, we have identified the non-

282 The fate of RNAPII in the course of this transcription-coupled repair (TCR)

283 In the course of this work we observed unanticipated con

284 In the course of this work we succeeded for the first ti

285 In the course of this work, we have assembled cross-spec

286 The evolution of 2D NMR peak volumes in the course of time provides further insight into the

287 ed by cognitive training interventions early in the course of treatment could facilitate personalized

288 ic radiotherapy should be administered early in the course of treatment, preferably beginning with cy

289 -ICU wards may require interventions earlier in the course of treatment.

290 t diagnosis or might become refractory later in the course of treatment.

291 erapies or measure response to therapy early in the course of treatment.

292 We detail critical steps in the course of trypanosome infection establishment tha

293 y examines the dual role of Escherichia coli in the course of ulcerative colitis (UC).

294 ferentially regulated genes on chromosome 10 in the course of validating RNA-Seq results using additi

295 Mercury is emanated in the course of various natural events and human activi

296 have both inhibitory and stimulatory effects in the course of vascular disease development.

297 nknown whether critical dynamics is affected in the course of wake and sleep, which would also impact

298 sicular body biogenesis, and other pathways, in the course of which it interacts with concave membran

299 ure of ShK toxin by racemic crystallography, in the course of which we discovered that d-ShK has a ne

300 Here comes the present review, in the course of which we try our best to address the hi