ライフサイエンスコーパス: in the early stage of

1 relational memory task in patients who were in the early stage of a psychotic illness.

2 In the early stages of a mouse model of human spinocereb

3 Typically, in the early stages of a pandemic, as seen with pandemic

4 d responding over the course of the trace CS in the early stage of acquisition.

5 unique actin species, which can be detected in the early stages of actin polymerization.

6 These results suggest that in the early stages of acute co-infection in the humaniz

7 In this work, 3xTg-AD mice in the early stage of AD were treated with SLAB51 probio

8 hat neuronal dysfunction and memory deficits in the early stages of AD are caused by the neuronal imp

9 -regulate blood-brain barrier P-glycoprotein in the early stages of AD has the potential to increase

10 been uncertain whether the observed amnesia in the early stages of AD is due to disrupted encoding a

11 Memory decline in the early stages of AD is mostly limited to episodic

12 n in the brain of individuals at risk for or in the early stages of AD.

13 effective strategy for treating memory loss in the early stages of AD.

14 l 3-kinase (PI3K)/Akt and PPARgamma pathways in the early stages of adipogenesis.

15 ding the structure of polyglutamine peptides in the early stages of aggregation.

16 ontribute to the generation of fasciculation in the early stages of ALS, while distal sites of origin

17 l diagonal band of Broca (vChATs) degenerate in the early stage of Alzheimer's disease (AD).

18 ling molecules, suggesting pathways involved in the early stages of Alzheimer disease.

19 e Entorhinal cortex (EC) has been implicated in the early stages of Alzheimer's disease (AD).

20 The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is cha

21 ic plasticity have been shown to be affected in the early stages of Alzheimer's disease.

22 rived from trimers have special significance in the early stages of Alzheimer's disease.

23 may be surrogate markers of retinal function in the early stages of AMD.

24 myeloid cells (IMCs) that markedly increase in the early stages of AMI.

25 In the early stages of amyloid formation, heterogeneous

26 In the early stages of an infection, pathogenic bacteria

27 The availability of epidemiological data in the early stages of an outbreak of an infectious dise

28 ological studies, which are rarely available in the early stages of an outbreak.

29 studies indicate that caspase-2 is involved in the early stages of apoptosis, particularly before th

30 Overaccumulation of IKU2 in the early stage of Arabidopsis seed development also

31 pha-1,2-mannosyltransferase, which functions in the early stages of asparagine-linked protein (N-) gl

32 Moreover, maintenance of the AM pool in the early stages of asthmatic inflammation depends on

33 insulin resistance and for events occurring in the early stages of atherosclerosis.

34 l and metabolism of atherogenic forms of LDL in the early stages of atherosclerosis.

35 isease and has very recently been implicated in the early stages of atherosclerosis.

36 dicates that motility is an important factor in the early stages of bacterial invasion.

37 has appeared in prescribing labeling and is in the early stages of being implemented into routine cl

38 n and enhances bone regeneration, especially in the early stages of bone healing.

39 lowing epithelial cells to bypass cell death in the early stages of breast cancer development.

40 and miR-23b - whose expression was increased in the early stage of C2C12 differentiation - are involv

41 aced the origin of this phenotype to defects in the early stages of CA stem formation.

42 mtDNA mutations might play an important role in the early stage of cancer development, possibly throu

43 esting that cyclin E plays an important role in the early stage of carcinogenesis.

44 tion profiles and that these play a key role in the early stages of carcinogenesis.

45 S. mutans was often observed at high levels in the early stages of caries but also in some healthy s

46 Several clock genes were disrupted in the early stages of cartilage degeneration in the DMM

47 We find that in the early stages of cavitation, bubbles are irregular

48 +) GR-1(+) subset of granulocytes before and in the early stage of cGVHD induction.

49 e benefits of reducing the c expansion range in the early stage of charging and suppressing the struc

50 dampen DC maturation or cytokine production in the early stages of chronic infection with either vir

51 ination of hepatic inflammation and fibrosis in the early stages of chronic liver diseases.

52 tolloid-like metalloproteinase is regulated in the early stages of classical conditioning and functi

53 e final stages of preclinical development or in the early stages of clinical application for monitori

54 te-specific membrane antigen PET tracers are in the early stages of clinical development.

55 and mTOR and immunomodulatory drugs that are in the early stages of clinical testing.

56 Many promising new drugs fail in the early stages of clinical trials.

57 t levels of oxygen are under development and in the early stages of clinical use.

58 ineurin-Aalpha also exhibited a nuclear bias in the early stages of cognitive decline.

59 showed that ZBP-89 protein was overexpressed in the early stages of colorectal cancer.

60 orm of tTLL, tTLLs, is transiently expressed in the early stages of conditioning during conditioned r

61 The results demonstrate that in the early stages of conditioning the initial activati

62 The work done in the early stage of contraction and the maximum power

63 In the early stages of critical illness, whether artific

64 rystals between metastable polymorphic forms in the early stages of crystal formation.

65 Aggregation of nanoparticles may dominate in the early stages of crystal growth, followed by surfa

66 unctions as a proapoptotic competence factor in the early stages of cytokine-induced pancreatic beta

67 he other mating type (mat A) and thus may be in the early stages of degeneration.

68 it was more affected in AD than in pure DLB, in the early stages of dementia.

69 ther prospective research involving subjects in the early stages of dementia.

70 ique, which is itself a photosynthetic organ in the early stages of development and undergoes a progr

71 eceptor-positive breast cancers, most tumors in the early stages of development depend on the activit

72 utput pathways; some of these new agents are in the early stages of development or undergoing proof-o

73 bidopsis and together have an essential role in the early stages of development that BSU1 is unable t

74 Given that these materials are still in the early stages of development, there is a lack of u

75 is is important and increasing but currently in the early stages of development.

76 ing is measurable and potentially modifiable in the early stages of development.

77 r crop improvement in this species are still in the early stages of development.

78 oup suggest vessel wall thickening occurring in the early stage of diabetes.

79 erapy shows promise as a renoprotective tool in the early stages of diabetic kidney disease.

80 In conclusion, in the early stages of diabetic nephropathy, the PT play

81 e, but globally these technologies are still in the early stages of diffusion.

82 rate here that activation of Stat3 by Sf-Stk in the early stage of disease is essential for the progr

83 port a model whereby the activation of Stat3 in the early stage of disease plays a pivotal role in re

84 nosis of PVAN, but is of limited sensitivity in the early stage of disease.

85 ging data are necessary for fine comparisons in the early stages of disease or response to treatment.

86 Moreover, administration of SPA in the early stages of disease substantially alleviated

87 ar ER induces enhanced mitochondrial fission in the early stages of DN formation and eventual mitocho

88 ing (HTS) methods is of paramount importance in the early stage of drug discovery.

89 of the DA system may have an important role in the early stages of drug abuse and may drive the incr

90 n identify potentially hepatotoxic compounds in the early stages of drug development would thus be va

91 ion on model animals is important especially in the early stages of drug development.

92 innovative compounds in chemical biology and in the early stages of drug discovery, and help investig

93 nabling efficient derisking and acceleration in the early stages of drug discovery, whilst also widen

94 fication of protein-ligand binding strengths in the early stages of drug discovery.

95 ool for a variety of drug metabolism studies in the early stages of drug discovery.

96 imbic system, two cellular processes engaged in the early stages of drug seeking.

97 owed that platelet and leukocyte recruitment in the early stages of DVT was dramatically higher in wi

98 2 in the endothelial and hematopoietic cells in the early stages of embryogenesis.

99 ace (structure factor) of the cell centroids in the early stages of embryonic development show struct

100 In the early stages of endocytosis, fPlas-gold nanoparti

101 ore, we identify Pu.1 as a Stat3 target gene in the early stages of erythroleukemia development.

102 It plays a critical role in the early stages of ES cell differentiation and the r

103 orm into legged robots during their lifetime in the early stages of evolution, and the anguilliform b

104 ) cells, which attenuate GN, into the kidney in the early stage of experimental crescentic GN.

105 ed in the past decade, researchers are still in the early stage of exploring the world of complex pro

106 y member Asporin (ASPN) plays a crucial role in the early stages of eye development in Xenopus embryo

107 uctural and transition heterogeneity is seen in the early stage of folding.

108 sordered on actin in a post-hydrolysis state in the early stages of force generation.

109 In the early stage of GA, when retinal sensitivity is re

110 n-rich junction clusters, demonstrating that in the early stages of gastrulation most subapical clust

111 issue components in the laminar region occur in the early stages of glaucomatous damage.

112 the development of the pathological changes in the early stages of globoid cell leukodystrophy assoc

113 hat genomic instability has a prominent role in the early stages of GOF p53 tumor progression (that i

114 Monocytes were involved in the early stages of granuloma formation and recruited

115 Direct observation of nanoparticles in the early stages of growth with unobtrusive laser pro

116 be kept under careful review, particularly, in the early stages of having commenced therapy.

117 Whether and which miRNAs are involved in the early stages of HCC development remains elusive.

118 s in response to macroautophagic dysfunction in the early stages of HD, but that the efficiency of th

119 ent of the cognitive difficulties that occur in the early stages of HD.

120 nisms underlying reduced cerebral blood flow in the early stages of heart failure, particularly when

121 to analyze a key receptor-ligand interaction in the early stage of hemostasis and thrombosis: the von

122 n gene and/or microRNA (miRNA) dysregulation in the early stages of hepatocarcinogenesis are hampered

123 roposed to explain restriction of X4 viruses in the early stage of HIV-1 diseases.

124 upplementation may be effective when started in the early stages of HIV disease.

125 s) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection.

126 y contributes to virulence of this bacterium in the early stages of host invasion and colonization.

127 clase toxin (CyaA) that plays a crucial role in the early stages of human respiratory tract colonizat

128 that impaired motivation is a major symptom in the early stages of Huntington's disease, when dopami

129 t reduction of BNP(1-32) and NT-proBNP(1-76) in the early stages of hypertension, with a significant

130 In the early stages of image analysis, visual cortex rep

131 ng the preparation of pathways needed later, in the early stages of imbibition.

132 Compliance with the new protocols in the early stage of implementation (chest CT, 58.9%; a

133 y) to 80.2% (2.7 vs 13.7 mGy) dose reduction in the early stage of implementation and 62.4% (6.5 vs 1

134 y) to 85.4% (2.8 vs 19.2 mGy) dose reduction in the early stage of implementation and 73.5% (4.9 vs 1

135 (arthritis and carditis) was attenuated only in the early stage of infection with DbpA/B-deficient sp

136 (DCs) or polymorphonuclear leukocytes (PMNs) in the early stage of infection; however, there was a Yo

137 was similar to that of nondiabetic controls in the early stages of infection but was more severe by

138 Understanding the mechanisms involved in the early stages of infection is crucial to determine

139 ce failed to control the replication of LCMV in the early stages of infection, they were capable of c

140 te immunity in controlling virus replication in the early stages of infection, which may shape the qu

141 ry response in an NF-kappaB-dependent manner in the early stages of infection.

142 prevent their acquisition by dendritic cells in the early stages of infection.

143 lity to rapidly detect and identify bacteria in the early stages of infection.

144 rovide some degree of protection to the host in the early stages of infection.

145 mponent that seems to play an important role in the early stages of infection.

146 d point to an unexpected role for T-channels in the early stage of information processing.

147 may be important for regulating autoimmunity in the early stages of insulitis, and the loss of IL-13R

148 In the early stage of ischemia-induced angiogenesis, Cat

149 on factors have yet been described as acting in the early stages of joint formation.

150 oss of the tumor-suppressor function of RelA in the early stages of Kras-driven pancreatic neoplastic

151 ayers to quasi-three-dimensional multilayers in the early stages of layer-by-layer growth.

152 novel word orders while human subjects were in the early stages of learning a new language.

153 However, there is evidence that in the early stages of learning, networks within multipl

154 ptation when chronically exposed to odorants in the early stage of life.

155 Trim28 may have a tumor suppressing role in the early stages of lung cancer.

156 In the early stages of lung development, the endoderm un

157 earned about proteins and pathways important in the early stages of malignant transformation and meta

158 only expressed during larval development and in the early stages of mammalian infection.

159 peri- and early postmenopause, while changes in the early stages of menopause were minimal.

160 key regulatory mechanism in the centrosomes in the early stages of mitosis, allosteric activation by

161 In this study, we demonstrate that FH acts in the early stages of monocyte to dendritic cell (DC) d

162 han the motor system that dominates learning in the early stages of motor skill acquisition.

163 the somatosensory system dominates learning in the early stages of motor skill acquisition.

164 tential effects of oral cladribine treatment in the early stages of MS.

165 The frequency of inflammatory episodes in the early stages of multiple sclerosis (MS) has been

166 s and in the induction of tumor angiogenesis in the early stages of neoplastic progression.

167 The goal of surgical intervention in the early stages of neuroblastoma is complete curativ

168 imbalance in brain ceramide and sphingosine in the early stages of neurodegeneration, preceding the

169 eased production of various cytokines occurs in the early stages of neuroinflammation and could have

170 of the excess synaptic contacts established in the early stages of neuronal development is required

171 Furthermore, in the early stages of nucleation, two different polymor

172 competition between cubic and hexagonal ice in the early stages of nucleation.

173 n detecting local high-order visual patterns in the early stage of object recognition hierarchy.

174 t, although C/EBPalpha plays a stronger role in the early stage of OC differentiation, it is also inv

175 these biopsy specimens may miss individuals in the early stages of oral prion infection and signific

176 experiments suggest that Runx1 is important in the early stages of osteoblast and chondrocyte differ

177 ther form the most common NF-kappaB complex, in the early stages of pancreatic malignant transformati

178 tle research has been undertaken with people in the early stages of Parkinson's disease although achi

179 inergic neurons that show signs of pathology in the early stages of Parkinson's disease, in mouse bra

180 ic phenotypic markers (tyrosine hydroxylase) in the early stages of Parkinson's disease.

181 therapy and occupational therapy in patients in the early stages of PD.

182 keyboards can be used to detect motor signs in the early stages of PD.

183 Membrane remodeling in the early stages of phagocytosis enables the engulfme

184 Our results suggest that PIP(3) is involved in the early stages of phagosome formation in E. histoly

185 ctional interplay between Mediator and TFIIH in the early stages of PIC development.

186 tion in imaging molecular calcium deposition in the early stages of plaque formation, when active upt

187 mesters in pregnancy (except for the patient in the early stage of pregnancy, in whom activity in the

188 cally not available during route scouting or in the early stages of process development.

189 cellular power plant and play a central role in the early stages of programmed cell death (apoptosis)

190 the irreversible axon degeneration produced in the early stages of progressive MS is mainly due to t

191 strate that Vitamin E promotes tumorigenesis in the early stages of prostate cancer evolution.

192 What happens in the early stage of protein folding remains an interes

193 The role of beta-sheets in the early stages of protein aggregation, specifically

194 r nsp2 species emerged almost simultaneously in the early stage of PRRSV infection.

195 suggest that measuring psychosocial outcome in the early stages of psychosis is important for our un

196 nd in particular VPS4, plays a critical role in the early stages of PV infection.

197 globule together with bound water molecules in the early stages of radiation damage to the protein c

198 t requires accurate cell divisions, not only in the early stages of rapid embryonic cleavages, but al

199 actions and biochemical conversions involved in the early stages of receptor-mediated signal transduc

200 cells that governs their recruitment to SpAs in the early stages of remodeling and has identified pot

201 ic species; and suggested that cytoform B is in the early stages of reproductive isolation whereas li

202 le for whooping cough, plays a critical role in the early stages of respiratory tract colonization by

203 cell patient, and identifying leukemia cells in the early stages of responding to a drug treatment.

204 ively correlated with choroidal degeneration in the early stages of retinopathy.

205 , potentially accounting for night blindness in the early stages of RP.

206 In the early stage of Salmonella colitis, PMNs are not r

207 n is more prominent than axonal degeneration in the early stage of schizophrenia, revealing a pattern

208 rity as inferred by DTI appear to be present in the early stages of schizophrenia, even in neurolepti

209 d of the hippocampus, is selectively reduced in the early stages of schizophrenia.

210 date psychosis onset but are more pronounced in the early stages of schizophrenia.

211 Endoplasmic reticulum (ER) stress occurs in the early stages of SCI and affects prognosis and cel

212 ext, we discuss the role of machine learning in the early stages of scientific discovery.

213 In the early stages of secondary growth, ARK2 is express

214 SR-BI-null mice had lower plasma LPS levels in the early stage of sepsis and elevated plasma LPS lev

215 In the early stages of sepsis, lymphocytes undergo apopt

216 eterochromatinization play an important role in the early stage of sex chromosome evolution.

217 s as a symptom of reduced amino acid content in the early stages of silique development.

218 pression of SMC differentiation marker genes in the early stages of SMC differentiation in vitro, whe

219 PRDM9 may play a wider, yet transient, role in the early stages of speciation.

220 s on PepN expression, localization, and role in the early stages of squid colonization.

221 ubset in SSc and likely play a critical role in the early stage of SSc skin disease.

222 e, although EDTA had some inhibitory effects in the early stages of storage.

223 e phenotype of cells involved in leukostasis in the early stages of streptozotocin-induced diabetes i

224 s indicate that LNP acts at a novel position in the early stages of symbiosis signaling.

225 disease initiation and cognitive impairment in the early stage of SZ.

226 elopment of strategies to prevent MCL-1 loss in the early stages of T1D may enhance beta-cell surviva

227 ker for mature beta cells, is down-regulated in the early stages of T2D in mice and when beta cells a

228 hy and thus identify the biochemical changes in the early stages of tendinopathy.

229 hibition of adipogenesis by arsenic occurred in the early stage of terminal adipogenic differentiatio

230 ves chromatin condensation that is initiated in the early stage of terminal differentiation.

231 blocked Nkx2.5 binding to the Myocd promoter in the early stage of TGF-beta induction, leading to inh

232 on between both processes were only apparent in the early stage of the aeration cells and the first c

233 stribution of phenylalanine oligomers formed in the early stage of the aggregation cascade.

234 ions induced by protein binding are required in the early stage of the binding process, so that the p

235 are resident in the skin lesions of patients in the early stage of the disease, exhibit an effector m

236 onstrate that CHFR is an important E3 ligase in the early stage of the DNA damage response, which med

237 n in the presence of macular edema, at least in the early stage of the inflammatory disease process.

238 nation seems to be the key diagnostic method in the early stage of the Kienbock's disease with negati

239 In the early stage of the reaction, the stepwise oxidati

240 n the seed by forming a core/shell structure in the early stage of the reaction.

241 but delays in the rollout of ART, especially in the early stages of the ART programme, have contribut

242 In addition, marker expression on cells in the early stages of the B-2 development pathway (CD19

243 -mediated degradation of CO that takes place in the early stages of the daylight period.

244 Muscle tissue in the early stages of the differentiation process exhib

245 ow seen as mainstay abnormalities that begin in the early stages of the disease and bear unfavorable

246 dystrophies, with two distinct morphologies in the early stages of the disease progression.

247 ion can be detected in high-risk individuals in the early stages of the disease to reduce the risk of

248 tion as an alternative to L-DOPA, especially in the early stages of the disease, being associated to

249 effective control of symptoms, particularly in the early stages of the disease, but disease progress

250 lusions predominantly localize to axons even in the early stages of the disease, but their affect on

251 ents without any PFT abnormalities and those in the early stages of the disease.

252 38% excess fracture risk among T2DM patients in the early stages of the disease.

253 may exhibit a subtle phenotype, particularly in the early stages of the disease.

254 the brain of adrenomyeloneuropathy subjects in the early stages of the disease.

255 sly non-specific, variable, and often absent in the early stages of the disease.

256 atment of established schizophrenia, but not in the early stages of the disorder.

257 ificantly greater extracellular water volume in the early stages of the disorder; however, its clinic

258 ant influence on the elevation repeatability in the early stages of the follow up period.

259 er the onset of AD, which might best be done in the early stages of the illness, may help address key

260 ases that present with non-specific symptoms in the early stages of the illness.

261 Although slow to develop in the early stages of the infection, T. cruzi-specific

262 In the early stages of the infection, the complex of P12

263 ed by TMD simulation to play a critical role in the early stages of the LacI conformational change.

264 membrane pressure (TMP) increase was similar in the early stages of the membrane runs for both raw wa

265 We compare temporal coding in the early stages of the olfactory and visual systems,

266 In the early stages of the reaction, Mes-Acr(+) is obser

267 B and T cells that were previously activated in the early stages of the response.

268 of a different, dimer structure is observed in the early stages of the second layer formation.

269 ed band 3 and protein 4.2 interact initially in the early stages of the secretory pathway and are fou

270 he key role the beta-sheet geometry acquired in the early stages of the self-assembly process plays i

271 wo fully formed kilometre-sized cometesimals in the early stages of the Solar System.

272 The response properties of neurons in the early stages of the visual system can be describe

273 thons can help academics, particularly those in the early stage of their careers, to build collaborat

274 terations in ocular and systemic circulation in the early stages of their disease process.

275 rstanding of clinical, in vivo tumor biology in the early stages of this deadly disease.

276 and the role of cytokines and growth factors in the early stages of this disease are poorly understoo

277 IGF-1/ephrinB1 axis plays significant roles in the early stages of tooth injury.

278 Many drugs are effective in the early stage of treatment, but patients develop dr

279 plex living samples is particularly critical in the early stages of tumor development.

280 In the early stages of tumorigenesis or during ischemia,

281 anism for the induction of tetraploidization in the early stages of tumorigenesis when telomere dysfu

282 pro-survival protein in PCa and reveal that, in the early stages of tumorigenesis, autophagy suppress

283 Telomerase reactivation may be critical in the early stages of tumorigenesis, when progressive t

284 Acquired resistance to TGFbeta is a key step in the early stages of tumorigenesis.

285 Because these dynamics are disrupted in the early stages of type 2 diabetes, dysregulation of

286 rty of microcantilever sensors, we are still in the early stages of understanding the fundamental sur

287 lack the reactive oxygen species (ROS) burst in the early stages of various stresses, as a result of

288 results establish a role for CHD5 and CASZ1 in the early stages of vertebrate cardiac development.

289 In the early stages of viral infection, outcomes depend

290 tein hemagglutinin (HA) plays critical roles in the early stage of virus infection, including recepto

291 EBOV glycoprotein (GP) plays critical roles in the early stage of virus infection, including recepto

292 PI3K/Akt/mTOR signaling inhibited autophagy in the early stages of virus-host cell interaction.

293 underlying orientation biases that operates in the early stages of visual processing before the cons

294 common basis, we show here that a difference in the early stages of visual processing between mammals

295 anding how visual information is represented in the early stages of visual processing.

296 ite extensive investigations, crucial events in the early stage of VRC01 development remain elusive.

297 copper that may guide pathology development in the early stages of WD.

298 ticular, Notch signaling appears to decrease in the early stages of wound healing which contributes t

299 In the early stages of wound healing, keratinocytes (KCs

300 R antagonism promoted wound repair processes in the early stages of wound repair, revealing a possibl