ライフサイエンスコーパス: in utero

1 ve cleft palate defects in Pax9(-/-) embryos in utero.

2 tuses following removal of the thyroid gland in utero.

3 sturbances in glutamate synaptic development in utero.

4 ntly increased by short photoperiod exposure in utero.

5 for neoplastic transformation if introduced in utero.

6 rns following exposure to chronic hypoxaemia in utero.

7 lay in the formation of an epidermal barrier in utero.

8 ed in females exposed to 42.5 ppm of arsenic in utero.

9 tating neurodevelopmental defects that occur in utero.

10 f cohesin proteins that established cohesion in utero.

11 ll infants potentially exposed to Zika virus in utero.

12 olytic metabolism, producing lactate for use in utero.

13 arly stages of cardiac diseases that develop in utero.

14 ariations in metabolic risk originate partly in utero.

15 t initiates a clinically silent pre-leukemia in utero.

16 mangioma is a rare vascular tumor that forms in utero.

17 inhibiting proliferation, both in vitro and in utero.

18 n part by alternative anaplerotic substrates in utero.

19 n transplant recipients and infants infected in utero.

20 ivation in placenta and foetal brain in vivo in utero.

21 disrupted by CUG(exp)-associated mechanisms in utero.

22 fetal immune system following viral exposure in utero.

23 nols and parabens may be harmful, especially in utero.

24 ssical in origin, and its development begins in utero.

25 erine vessels and might improve fetal growth in utero.

26 result from neurological insults that begin in utero.

27 difications associated with mercury exposure in utero.

28 determinant of fetal growth and development in utero.

29 the onset of the disease during development in utero.

30 l mass and circulating insulin concentration in utero.

31 -/- mice exhibit a myogenesis defect already in utero.

32 on-invasive whole-placenta perfusion imaging in utero.

33 D induced by exposure to valproic acid (VPA) in utero.

34 gulation of fetal nervous system development in utero.

35 Pharmacological ERK inhibition in utero abolished the abnormally enlarged lymphatic ves

36 ted in immunocompromised patients and during in utero acquisition.

37 We propose that in utero administration of CPCs may have future implicat

38 In utero administration of wild-type CPCs into the heart

39 s Webster mice were exposed to 100 ppb AsIII in utero, after weaning, or both.

40 hese associations have not been examined for in utero ambient nitrate exposure.

41 group of 751 neonates exposed to MR imaging in utero and a group of control subjects comprising 10 0

42 nother group of Gjb2-CKO mice received ACEMg in utero and after weaning.

43 mmon infantile hemangiomas in that they grow in utero and are fully developed at birth.

44 Childhood stunting usually begins in utero and continues after birth; therefore, its reduc

45 In utero and continuous early-life exposure to AsIII dis

46 We examined the association of air pollution in utero and during early life with pubertal development

47 Among 1,938 girls, PM10 exposure in utero and during infancy was negatively associated wi

48 temporal structure during development, both in utero and early postnatal life.

49 In Utero and early-life exposure to ambient air toxics a

50 The workshop focused on (1) in utero and early-life origins of asthma, (2) the use o

51 els of autism: mice exposed to valproic acid in utero and Fmr1 knockout mice.

52 le) and 94 normally grown fetuses identified in utero and followed-up into preadolescence (8-12 years

53 o measure brain function in 32 human fetuses in utero and found that systems-level neural functional

54 because of its ability to cause microcephaly in utero and Guillain-Barre syndrome in adults.

55 Exposure to the farming environment in utero and in early childhood had little or no associa

56 ividual is exposed to different temperatures in utero and in early childhood, and we estimate flexibl

57 mental risk factors occurring preconception, in utero and in the early postnatal period.

58 ay with mean temperatures above 32 degrees C in utero and in the first year after birth is associated

59 Our data suggest that in utero and infancy exposures to air toxics generated b

60 child growth, if it exists, is most profound in utero and is not universally effective across all cou

61 use of birth defects among newborns infected in utero and morbidity and mortality in transplant and A

62 Safety outcomes were deaths in utero and neonatal deaths and were assessed in all ra

63 ing projects on 2 families with a history of in utero and neonatal deaths associated with nonimmune h

64 In utero and post-weaning exposure to trivalent arsenic

65 Additionally, QIPAVA is present in utero and shortly after birth, but is reduced in olde

66 rom mice that were exposed to diesel exhaust in utero and that have subsequently undergone transverse

67 s play important roles in ocular development in utero and throughout the life span, in vision perform

68 f gestation) who had been exposed to opioids in utero and who had signs of the neonatal abstinence sy

69 toimmunity directly, even during development in utero, and be involved in regulation of autoimmunity

70 ety outcomes including abortion, fetal death in utero, and congenital anomalies.

71 The most vulnerable exposure period may be in utero, and future regulations should also aim to redu

72 genes governing normal germ cell development in utero are implicated in the development of TGCT.

73 types of offspring that were exposed to METH in utero are vulnerable to (a) METH exposure during embr

74 These mice express KrasG12D in utero, are born at normal Mendelian ratios, develop h

75 We investigated whether in utero arsenic exposure affects the risk of infections

76 Relation between in utero arsenic exposure and birth outcomes in a cohort

77 We assessed in utero arsenic exposure in relation to birth outcomes

78 However, the effects of in utero arsenic exposure on general physiological funct

79 through drinking water and diet, we assessed in utero arsenic exposure using maternal second-trimeste

80 In utero arsenic exposure was associated with a higher r

81 e explanation is that risk of obesity begins in utero as a result of developmental plasticity during

82 opment of IBS, with environmental influences in utero as the most relevant contributing factor.

83 ose of the same postconception age but still in utero at the time of collection.

84 e hypertrophic and/or dilated cardiomyopathy in utero, at birth, or in early childhood.

85 This study represents the first successful in utero attempt to induce scarless repair in late-gesta

86 This possible in utero 'birth-order' T-cell programming may contribute

87 We used in utero bisphenol A (BPA) exposure as a model environme

88 In-utero BOLD MRI time series were acquired at 29 to 34

89 In utero BPA exposure altered the global CpG methylation

90 We previously found that in utero caffeine exposure causes down-regulation of DNA

91 This report shows that in utero caffeine exposure has long-term effects into ad

92 ng those that occur during fetal development in utero, can cause epigenetic effects that modulate DNA

93 s, our results indicate that hNCCs, injected in utero, can integrate into the embryo and form mature

94 xposure, medication) in children affected by in utero cannabinoid exposure.

95 evealed a significantly higher prevalence of in utero CMV infection in ALL cases (n = 268) than healt

96 In utero CMV infection induced oligoclonal expansions of

97 In utero coadaptive development of the placenta and hypo

98 dicate that IDLVs may be efficient tools for in utero cord transduction in therapeutic strategies suc

99 amming facilitates fetal adaptation to these in utero cues.

100 Although longer follow-up is needed, these in utero data are reassuring and support the continued u

101 Fluconazole treatment in utero decreased intestinal C.albicans colonization, m

102 urine model of the disease and suggestive of in utero depletion of this neuronal population as a cons

103 ution of (44)Ca/(42)Ca ratios in enamel from in utero development to first months of postnatal develo

104 tion, providing a framework of stability for in utero development with most growth variance occurring

105 In utero disruption resulted in more pronounced social a

106 ential for development as knock-out mice die in utero due to placental defects caused by misregulated

107 a time-delimited binge-type ethanol exposure in utero during early gestation alters corticopetal tang

108 diated inhibition of Dickkopf (DKK) activity in utero during palatal shelf morphogenesis partly rescu

109 sulfur dioxide and nitrogen dioxide exposure in utero, during infancy, and in childhood were negative

110 idual (i.e. case) or the mother (e.g. via an in utero effect) that influence the risk of LSLs.

111 ic precursors of these cortical neurons were in utero electroporated with CBSH3- or CBSH3+ DNAs, migr

112 ) in the adult rat cerebral cortex following in utero electroporation (IUEP) at embryonic stage E14.

113 NQ2(I205V) into L2/3 pyramidal neurons using in utero electroporation also results in a hyperexcitabl

114 e of its endogenous environment, using mouse in utero electroporation and a conditional genetic strat

115 a novel technique called iTRAP that combined in utero electroporation and translating ribosome affini

116 Moreover, an in utero electroporation approach showed that PNH-relate

117 C)-specific postnatal knockdown of DISC1 via in utero electroporation combined with an inducible knoc

118 Using in utero electroporation during corticogenesis, we show

119 Using shRNA in utero electroporation in mice, we show that Vrk1 knoc

120 At 2 days after in utero electroporation into the ventricle of the devel

121 role of Cenpj during cortical development by in utero electroporation knockdown and found that silenc

122 knockdown of Fat1 in cortical precursors by in utero electroporation leads to overproliferation of r

123 ng Nex-Cre-mediated recombination as well as in utero electroporation of a Cre-expression construct i

124 Lmnb1 silencing in mouse embryonic brain by in utero electroporation of a specific Lmnb1 sh-RNA resu

125 In utero electroporation of L1-80 into reeler embryos no

126 Here using in utero electroporation of NDE1 short hairpin RNA (shRN

127 , ex vivo AICD delivery or APP knock-down by in utero electroporation of shRNAs with whole-cell elect

128 CAPZB2 expressed by in utero electroporation prevented normal elongation of

129 DGCR2 mutation in mouse corticogenesis using in utero electroporation targeted to projection neurons.

130 Using in utero electroporation to manipulate the sumoylation s

131 Using in utero electroporation, we here report that MBG3 mouse

132 Using in utero electroporation, we show here that the IGF-1R i

133 Furthermore, through in utero electroporation, we show that downregulation of

134 ery to dividing neuronal progenitors through in utero electroporation.

135 5 genetic mosaic mice were generated through in utero electroporation.

136 In utero, electroporation demonstrates that activation o

137 preterm delivery and alleviated fetal demise in utero elicited by i.p. LPS administration in late ges

138 lt to distinguish between the effects of the in utero environment and epigenetic factors contributed

139 al age and can be affected by changes to the in utero environment and maternal immunity.

140 Premature birth terminates the hypoxic in utero environment and supply of maternal hormones.

141 y of metabolites as biomarkers/indicators of in utero environmental exposure.

142 ns in pregnancy that could result in adverse in utero environments.

143 Only very early in utero events could affect IPL lamination in the centr

144 In utero experience, such as maternal speech in humans,

145 btaining the number of common changes in the in utero-exposed prospermatogonia and the same cells in

146 methylated regions as a result of both METH in utero exposure and maternal care.

147 OHAD) hypothesis, which holds that stressful in utero exposure manifests as disease in adulthood.

148 We found that in utero exposure of rats to DINCH from gestational day

149 Little is known about in utero exposure to and postnatal clearance of anti-tum

150 In utero exposure to arsenic can affect fetal, newborn,

151 We aimed to assess the joint effect of in utero exposure to arsenic, manganese, and lead on chi

152 Our findings revealed unexpected effects of in utero exposure to arsenic: exposure to both a human-r

153 We sought to determine whether in utero exposure to BPA altered the global CpG methylat

154 ergic asthma (AA) is inexplicably rising and in utero exposure to cigarette smoke increases the risk

155 In utero exposure to diesel exhaust air pollution has be

156 in neonatal cultured cardiac myocytes after in utero exposure to diesel exhaust and found that the p

157 In utero exposure to diesel exhaust particulates is asso

158 ylation within cardiomyocytes as a result of in utero exposure to diesel exhaust.

159 Emerging animal data suggest that in utero exposure to dietary refined carbohydrates may p

160 In utero exposure to EDCs may affect disease propensity

161 highly sensitive to xenobiotic toxicity and in utero exposure to environmental toxins affects physio

162 In utero exposure to glucocorticoids (iuGC) triggers pro

163 We evaluated the effects of in utero exposure to inorganic arsenic at the U.S. Envir

164 cells, demonstrate that ASD can result from in utero exposure to maternal brain-reactive antibodies

165 We investigated whether in utero exposure to maternal pregravid obesity and/or g

166 ased risk of autism and evidence associating in utero exposure to some antidepressants and neurodevel

167 spiratory failure, which can be mitigated by in utero exposure to the antioxidant, N-acetyl-cysteine.

168 are found in juvenile macaque tissues after in utero exposure to two doses of gadoteridol, indicatin

169 In utero exposure to VPA in humans or rodents results in

170 tudy confirms a specific association between in utero exposure to ZDV and CHDs, and a long-lasting po

171 ation was attributed to a critical window of in utero exposure.

172 ffspring asthma development, suggesting that in utero exposures can influence offspring asthma.

173 , our findings raise the question of whether in utero exposures may affect the risk of atopic dermati

174 In utero exposures to drugs thus can have long-lasting i

175 t and function and, in turn, for appropriate in utero fetal growth.

176 eterm birth (PTB) is commonly accompanied by in utero fetal inflammation, and existing tocolytic drug

177 that approximate the body composition of the in utero fetus from 30 to 36 wk of gestation.

178 achieve body composition that replicates the in utero fetus, but intrauterine body composition refere

179 ests that diffuse white matter injury begins in utero for a significant proportion of preterm infants

180 Mice lacking TFPI (Tfpi(-/-)) die in utero from disseminated intravascular coagulation.

181 To dissociate in utero from postnatal effects, a subset of litters was

182 The majority of the in utero gadolinium chelate was found in the amniotic fl

183 Here, we show in utero gain-of-function of the psychiatric risk gene t

184 expression in mouse pyramidal neurons using in utero gene delivery methodologies.

185 Finally, we demonstrated that in utero gene therapy for Pqbp1-cKO mice by intraperiton

186 the context of the embryonic brain using an in utero gene transfer tool.

187 Now using the approach of in utero gene transfer we have discovered that Ulk4 play

188 Exposure to BPA in utero has been linked to female reproductive disorder

189 dinal characterization of early brain growth in-utero has been limited by a number of challenges in f

190 Mice exposed to high levels of arsenic in utero have increased susceptibility to tumors such as

191 In utero hematopoietic cell transplantation (IUHCT) is a

192 engraftment has been demonstrated following in utero hematopoietic cellular transplantation during i

193 Using a murine model of in utero hematopoietic cellular transplantation, the imp

194 In utero hematopoietic stem cell transplantation (IUHCT)

195 tion may represent a novel mechanism linking in utero Hg exposure and adverse infant neurobehavioral

196 These findings may represent an in utero immune priming effect of the fetal immune syste

197 ma, and allergy in childhood pointing toward in utero immune programming of the child.

198 ed the in vivo electroporation strategy used in utero in rodents and in ovo in poultry, and apply it

199 oorly understood, especially when they occur in utero, in part due to the lack of genetic animal mode

200 ction of TRBP into the mouse embryonic brain in utero increased the fraction of cells expressing Sox2

201 ce of the pathogen might be attributed to an in-utero infection, acquisition from maternal flora, or

202 gramming of microglia in neonates exposed to in utero inflammation via an endogenous cerebral choline

203 This finding supports the notion that in utero influences may contribute to higher cardiometab

204 In utero injection of adjuvant-free ovalbumin (OVA) was

205 onatal cardiac dysfunction can be rescued by in utero injections of wild-type CPCs into Speg(-/-) foe

206 The last trimester in utero is critical in neuromotor development, as this

207 vidence that atopic eczema partly originates in utero is increasing, with some studies linking the ri

208 ar growth in newborns suggests that stunting in utero is unlikely to be reduced by supplemental food

209 rkably, protection against fetal wastage and in utero L. monocytogenes invasion was maintained even w

210 Moreover, pups exposed to WIN in utero lacked constitutive CB1R-mediated suppression o

211 In utero latent iron deficiency has been associated with

212 dothelial progenitor cells that GDM exposure in utero leads to altered gene expression and DNA methyl

213 the likelihood of adult asthma and exposure in utero led to a 7.91 percentage point increase (95% CI

214 live imaging, genetics, cell-cycle analyses, in utero lentiviral transduction, and lineage-tracing, w

215 itulate the defining features of JMML due to in utero lethality, nonhematopoietic expression, and the

216 r placental mammals, the transition from the in utero maternal environment to postnatal life requires

217 Exposures to environmental pollutants in utero may increase the risk of adverse health effects

218 ggest that exposure to artificial sweeteners in utero may predispose offspring to develop obesity; ho

219 Neuroinflammation in utero may result in life-long neurological disabiliti

220 ing (MRI) have made possible high-resolution in utero measurements of water diffusion anisotropy in t

221 minimize the risk of relapse while avoiding in utero medication exposure.

222 ntity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk

223 o did not have a typical retinal development in utero (microphthalmics).

224 erozygous NOS3(+/-) (KOP: mother with normal in utero milieu) and NOS3(+/+) (WT) litters.

225 as used to obtain high-speed image data from in utero mouse embryos and multi-angle, vector-flow algo

226 w understanding to this subject using serial in utero MRI measurements of rhesus macaque fetuses, fro

227 In-utero MRI (iuMRI) has shown promise as an adjunct to

228 the association between maternal anxiety and in utero neurodevelopment is modified through complex ge

229 nicotine exposure, as opposed to maternal or in utero nicotine exposure, this study underlines the im

230 Suboptimal in utero nutrition combined with accelerated postnatal c

231 erse effects of exposure to 1.5-T MR imaging in utero on neonatal hearing function or birth weight pe

232 exposure to energy and nutrient restriction in utero on their children's growth in rural Gambia.

233 rt of children who were exposed to vitamin A in utero or at birth.The aim of this study was to examin

234 In utero or early postnatal life (< 7 weeks), before ons

235 tors, to account for hypertension; moreover, in utero or early postnatal life may represent a possibl

236 ype ranges from foetal akinesia resulting in in utero or neonatal mortality, to milder disorders that

237 variations and adverse environmental events in utero or shortly after birth can lead to abnormal bra

238 thma between those exposed to the Great Smog in utero or the first year of life with those conceived

239 Affected members developed in utero- or neonatal-onset muscle weakness of variable

240 in childhood and even adulthood may have an in utero origin, and the placenta is a key organ that pl

241 Influence of intergenerational in utero parental energy and nutrient restriction on off

242 ny time in proximity to conception or during in utero, perinatal, or childhood time periods.

243 Upon ketamine exposure in utero, PFC neurons at P30 showed more dendritic branc

244 es were conducted to identify the effects of in utero PFOS exposure on neonatal testes and its relati

245 n image-processing technique was shown in an in utero placental study.

246 atinocyte-specific deletion of the Rbpj gene in utero produced a significantly milder phenotype than

247 cts' on disease risk is largely unknown, but in utero programming of the child's immune system may pl

248 Prenatal genetic testing to diagnose DS in utero, provides the novel opportunity to initiate ear

249 mine how the tactile stimulation experienced in utero relates to the spatial environment newly offere

250 eutic strategies to manage disease processes in utero represent a powerful new approach for clinical

251 has been actively investigated for decades, in utero restoration of scarless healing in late-gestati

252 Manipulations of androgen signaling in utero reveal a temporal window of development when si

253 of the immune system, leading to an event of in utero sensitization.

254 ing public drug coverage in Ontario, Canada, in utero serotonergic antidepressant exposure compared w

255 We show via in utero shRNA-mediated suppression that a balanced supp

256 .5% and increased the number of live fetuses in-utero significantly compared to respective controls 4

257 changes in the F1 generation were related to in utero somatic reprogramming.

258 c retinal cultures and Dlx2 gain of function in utero strongly support that DLX2 is both necessary an

259 atory responses, and its inhibition improves in-utero survival of live fetuses.

260 ess the associations between the duration of in utero TDF exposure and change in FLZ and HLZ.

261 there was no association between duration of in utero TDF exposure per 1-week increment and change in

262 The duration of in utero TDF exposure was calculated in weeks.

263 w data exist on fetal bone development after in utero TDF exposure.

264 mmunocompromised adults and infants infected in utero The dissection of the HCMV entry machinery is i

265 of both proteins resulted in added mortality in utero The FBLN1/FGF8 interaction may also be involved

266 Together with altered cerebral perfusion in utero, these factors are associated with abnormalitie

267 Although ARID3a/Bright knockout mice died in utero, they exhibited decreased numbers of hematopoie

268 In young adult offspring exposed to ethanol in utero, this effect persisted as an increase in the nu

269 acenta and hypothalamus has enabled critical in utero timing for the development of fetal Leydig cell

270 this, we maternally exposed developing mice in utero to gestational diabetes mellitus (GDM) and/or m

271 SD were twice as likely to have been exposed in utero to preeclampsia as controls with TD after adjus

272 In the current study, rats were subjected in utero to RNA interference targeting of the gene Dcdc2

273 s homolog, MDMX, is necessary and sufficient in utero to suppress p53 but is dispensable during adult

274 strate that male but not female mice exposed in utero to the C6 monoclonal antibody, binding to conta

275 rget of ethanol by limiting ethanol exposure in utero to the gestational window when tangential migra

276 om the onset of isolated orofacial movements in utero to the postnatal mastery of suckling at 4 month

277 ong 50 infants, girls (but not boys) exposed in utero to ZDV/lamivudine/ritonavir-boosted lopinavir (

278 l abnormalities observed in neonates exposed in utero to Zika virus (ZIKV) is needed to develop treat

279 role for B cells and immunoglobulins during in utero tolerance priming.

280 compared: 1) adeno-associated virus-mediated in utero transfer of the ChR-2 gene into the developing

281 in CD4(+) T central memory cells to promote in utero transmission of HIV-1.

282 ve-attenuated vaccine platforms can restrict in utero transmission of ZIKV in mice, their further dev

283 the generation of protective responses, and in utero transmission of ZIKV infection remain unclear.

284 placental and fetal disease associated with in utero transmission of ZIKV.

285 l facilitate the study of ZIKV pathogenesis, in utero transmission, and testing of therapies and vacc

286 Furthermore, in utero treatment with either lithium chloride, an agon

287 t across three etiologically distinct models-in utero valproic acid (VPA) exposure, CNTNAP2 knockout

288 ot all, previous studies have suggested that in utero vitamin D exposure may be a risk factor for MS

289 standing the metabolic mechanisms related to in utero vitamin D exposure may therefore shed light on

290 goal was to analyze the programming role of in utero vitamin D exposure on children's metabolomics p

291 rs, and cluster membership was influenced by in utero vitamin D exposure, suggesting a prenatal progr

292 ure to SHS in infancy without prior exposure in utero was associated with an excess risk of food sens

293 rnal exposure to seasonal energy restriction in utero was associated with reduced offspring birth len

294 rients that other species groups may provide in utero, we examined changes in the lipids of colostrum

295 -deficient mouse models of ZIKV transmission in utero, we found that the placenta and fetus were more

296 cal and logistical) of exploring development in utero, we understand little of how the ventricular wa

297 rease in cell proliferation and osteogenesis in utero, while other organ defects were not corrected.

298 e the neurologic outcome of infants infected in utero with HCMV.

299 ence that asthma and atopy originate in part in utero, with disease risk being associated with the al

300 netic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure.