ライフサイエンスコーパス: in vitro

1 oscillating with distinct phases in vivo and in vitro.

2 ptosis of M1 macrophages previously observed in vitro.

3 r specimens in vivo and in cancer cell lines in vitro.

4 okine release of bone marrow dendritic cells in vitro.

5 ena cava, and diminished platelet activation in vitro.

6 vestigated the interaction of FtsZ with ZipA in vitro.

7 oteins contribute to cellular transformation in vitro.

8 cking activity of post-AIT sera was assessed in vitro.

9 fully reconstituted the underlying processes in vitro.

10 erved differences in lipin phosphoregulation in vitro.

11 CD28 beads and gave rise to CD161(-) progeny in vitro.

12 to increased platelet yield in vivo, but not in vitro.

13 regions are particularly good AID substrates in vitro.

14 d ALDH-positive cancer stem cell population, in vitro.

15 ance microtubule growth rate by several-fold in vitro.

16 sion is also spatially regulated in vivo and in vitro.

17 hydrogel containing naringin, were evaluated in vitro.

18 , we modeled ICC desmoplasia and progression in vitro.

19 e that Pol epsilon can act in eukaryotic MMR in vitro.

20 ic differentiation of DPSCs both in vivo and in vitro.

21 so, US28 facilitates HCMV spreading in VSMCs in vitro.

22 sembly is stimulated by Plk1 phosphorylation in vitro.

23 CK knockdown in differentiated human neurons in vitro.

24 e expression compared to 3R4F smoke exposure in vitro.

25 nhance the mineralization potential of DPSCs in vitro.

26 mesenchymal stem cells (hMSCs) was evaluated in vitro.

27 sed by their ability to inhibit Ab responses in vitro.

28 t T cells, a previously unrecognized target, in vitro.

29 used to investigate single molecule dynamics in vitro.

30 acteria during at least 4 hours of infection in vitro.

31 immunity and Th17-skewing human cell culture in vitro.

32 sumably all the cell types of the human body in vitro.

33 dicating the generation of prion infectivity in vitro.

34 ctin binding and decreased thermal stability in vitro.

35 ter was decreased upon methylation treatment in vitro.

36 nd also potentiated oncogenic transformation in vitro.

37 te additional functions for RbpA not evident in vitro.

38 elial electrical resistance in an all-human, in vitro, 3-dimensional, blood-brain barrier model exemp

39 -derived mesenchymal stromal cells (MSC) and in vitro 3T3-L1 preadipocytes significantly increases th

40 In vitro activation revealed that patients with CVID beh

41 n cells derived from alcohol users and after in vitro acute alcohol treatment of human MDDCs.

42 *,S**)-22e, in particular, exhibited optimal in vitro ADME and pharmacokinetics properties and dose-d

43 ned bortezomib and doxorubicin were observed in vitro against both multiple myeloma and ovarian cance

44 This identified a hit that subsequent in vitro analysis showed directly binds and inhibits pur

45 In vitro analysis showed that PRN694 effectively inhibit

46 Taken together, by combining in vivo and in vitro analysis using TC10-deficient mice, we define t

47 approximately 100 colony-forming units (CFU) in vitro and <1000 CFU in the lungs of mice.

48 C5C blocked netrin-1-promoted axon repulsion in vitro and caused defects in axon projection of DRG to

49 In vitro and cell-based assays revealed that the CNAbeta

50 In an in vitro and cell-based model of MMP-dependent breast ca

51 stains wild-type and Il7ra(-/-) ILC survival in vitro and compensates for IL-7R deficiency, as residu

52 d CAR T cell mediated killing of tumor cells in vitro and enhanced clearance of PD-L1+ tumor xenograf

53 basis of KIR3DL1/HLA-B subtype combinations in vitro and evaluated their impact in 1,328 patients wi

54 tion restored HLA class-I surface expression in vitro and in a mouse xenotransplantation model.

55 screened it for pyrazinamide resistance both in vitro and in an infected animal model.

56 R significantly reduced drug resistance both in vitro and in computational model.

57 e genes in undifferentiated progenitor cells in vitro and in embryonic mouse livers.

58 how that CCAR2 is required for proliferation in vitro and in established SCC tumors in vivo.

59 with augmented activation of the ERK pathway in vitro and in hearts in vivo.

60 um PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquito

61 ate cancer or hepatocellular carcinoma cells in vitro and in mouse xenografts.

62 erences exhibited by both Leptosphaeria spp. in vitro and in planta.

63 nocyte proliferation and increased apoptosis in vitro and in skin grafts regenerated on mice, which w

64 nt tool to study infection with the pathogen in vitro and in vivo and the immune response to these ba

65 monstrated to reduce amyloid deposition both in vitro and in vivo Because N-terminally truncated pyro

66 obots have the potential to be used for both in vitro and in vivo biomedical applications.

67 G also exerts a broad anti-leukemic activity in vitro and in vivo by inhibiting leukemia cell prolife

68 This article describes the preclinical in vitro and in vivo characterization of 3 novel compoun

69 Here, we report in vitro and in vivo effects of inhibiting PI3Kdelta in

70 he vectors exhibited stable RSV F expression in vitro and in vivo In conclusion, an attenuated rHPIV1

71 We confirmed these findings in vitro and in vivo in two murine tumor models, in prim

72 ents, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT

73 Using both in vitro and in vivo models, we go on to demonstrate tha

74 exerts a powerful angiogenic effect in both in vitro and in vivo mouse studies.

75 d YAP/TAZ in mediating metastatic phenotypes in vitro and in vivo Notably, pharmacologic targeting of

76 , exogenous expression of ACTRT1 reduced the in vitro and in vivo proliferation rates of cell lines w

77 Endothelial cell angiogenic responses in vitro and in vivo require ETS1-mediated transduction

78 In this in vitro and in vivo study we hypothesized that the hepa

79 e efficient apoptotic cancer cell death both in vitro and in vivo through tumor-specific (1) O2 gener

80 and experimental models of immune responses in vitro and in vivo to quantify the spatial extent of c

81 CCSCs (93% accuracy) were employed for both in vitro and in vivo tumor phenotyping to identify the t

82 S cells retain the capacity to differentiate in vitro and in vivo upon downregulation of OCT4 express

83 ote-loaded nanoformulations are studied both in vitro and in vivo using animal disease models.

84 es, is regulated by parathyroid hormone both in vitro and in vivo, and protects osteocytes from oxida

85 Absence of CD200L signaling, both in vitro and in vivo, resulted in a higher inflammatory

86 y by site-directed mutagenesis and expressed in vitro and in vivo, the preparation of proteins phosph

87 ated TGF-beta1-mediated profibrotic pathways in vitro and in vivo, while esculetin significantly inhi

88 assess biomaterial-tissue interactions both in vitro and in vivo.

89 ligomers that can act as a therapeutic agent in vitro and in vivo.

90 hysical properties and Pab1 phase separation in vitro and in vivo.

91 of XRN2 induced EMT and promoted metastasis in vitro and in vivo.

92 ser536) phosphorylation and c-Myc expression in vitro and in vivo.

93 d the malignant phenotypes of SCC cells both in vitro and in vivo.

94 wth factor (TGF)-beta1 to -beta3 translation in vitro and in vivo.

95 isolated HEV particles that were infectious in vitro and in vivo.

96 hat IRF8 is required for Th9 differentiation in vitro and in vivo.

97 ion, and characterized biochemical functions in vitro and in vivo.

98 TAM-dependent anti-estrogen chemosensitivity in vitro and in vivo.

99 B-SOs) in CYP1A1-positive cancer cells, both in vitro and in vivo.

100 rrelated with increased mast cell activation in vitro and in vivo.

101 egulated under a high glucose condition both in vitro and in vivo.

102 apoptosis in MDA-MB-231 breast cancer cells in vitro and in vivo.

103 d invasive capabilities of lung cancer cells in vitro and in vivo.

104 hile other compounds could suppress it, both in vitro and in vivo.

105 sistance of AML cell lines and primary cells in vitro and in vivo.

106 ificantly inhibited Wnt/beta-catenin pathway in vitro and in vivo.

107 gered by a decrease in hDBR1 expression both in vitro and in vivo.

108 ion of neurodegeneration-associated proteins in vitro and in vivo; however, the regulation of HSJ1 fu

109 of the CXCR2(+) stem cells, as validated by in vitro and in-matrix migration assays.

110 dizolid is a new oxazolidinone with improved in vitro and intracellular potency against Mycobacterium

111 e of the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds, s

112 has been shown to enhance viral replication in vitro and severe disease in animal models.

113 of cysteine transport to trigger ferroptosis in vitro and slow tumour growth.

114 ition, H9C2 rat cardiomyocytes were cultured in vitro and the phosphorylation of ERK1/2, AKT, GSK3bet

115 R mutation confers enhanced FcRn interaction in vitro, and Abs harboring either the Q311R or TLQ muta

116 mphopoiesis in a non-cell-autonomous fashion in vitro, and depletion of the Hh effector Smoothened (S

117 mutations showed similar behaviors in yeast, in vitro, and in Drosophila, a few showed anomalous beha

118 In sum, our complementary in silico, in vitro, and in vivo analysis argues that interface add

119 abilizes microtubules using cell biological, in vitro, and structural approaches.

120 iciently cleaved DSP into distinct fragments in vitro, and the deletion of Mmp9 caused improper proce

121 gh the MS-AFST assay performed at 3 h of the in vitro antifungal exposure failed to detect C. glabrat

122 permeability in the PAMPA-BBB model and high in vitro antioxidant activity, its conversion to AChEI 2

123 t-saving extraction-free procedure measuring in vitro antioxidant capacity which appears highly relev

124 rs and analysis devices in a wide variety of in-vitro applications.

125 Here we combine in silico and in vitro approaches to characterize the SOS transcriptio

126 rates and Gly-terminated nucleophiles occurs in vitro as well as in cellulo in the presence of Ca(2+)

127 in-bearing endothelium under flow conditions in vitro as well as increased BM trafficking and extrava

128 Using a visual in vitro assay we previously showed that efficient prote

129 is question, we exploited a prion conversion in vitro assay, protein misfolding cyclic amplification

130 invasion of prostate cancer cell lines in 3D in vitro assays.

131 with highly responsive platelets to agonists in vitro assessed by flow cytometry (high-responder dono

132 Importantly, through in vitro binding and activity assays, we showed that CML

133 C/D) Intriguingly, coimmunoprecipitation and in vitro binding assays revealed that mortalin facilitat

134 4 exhibited low-affinity binding to LRP6 in in vitro binding assays, and inhibition of LRP6 or criti

135 In vitro binding studies showed that whereas mutation of

136 ted CYP27A1 by >/=75% and were evaluated for in vitro binding to the enzyme active site and for inhib

137 ating alleles, live-cell spindle assays, and in vitro biochemical analyses, we show that She1 is requ

138 ption bursting that could not be obtained by in vitro biochemistry analysis.

139 In this study, in vitro biophysical and biochemical methods were utiliz

140 ave well documented immunomodulatory effects in vitro, but not following oral administration in human

141 pecifically degraded single-strand (ss) RNAs in vitro; but neither miRNAs nor miRNA*s in vivo.

142 These altered responses could be corrected in vitro by treatment with NKH-477, a compound discovere

143 In vitro, CD44TA-SMP accumulated in macrophages infected

144 panel of gp120 proteins to alpha4beta7 in an in vitro cell binding assay.

145 Using in vitro cell culture and in vivo mouse models, we showe

146 Further in vitro cell culture experiments and gene expression an

147 the availability of large numbers of cells, in vitro cell expansion of tooth-inducing cell populatio

148 FES binding was measured by using an in vitro cell uptake assay.

149 h the severity of growth retardation and the in vitro cellular phenotype.

150 In silico and in vitro characterisation show that these mutations pert

151 of P. simiae genes to growth in 90 distinct in vitro conditions by RB-TnSeq, highlighting specific m

152 The Ctk1 kinase complex binds RNA in vitro, consistent with direct EF-RNA interaction.

153 Using an in vitro culture model yielding human mo-DCs and mo-Macs

154 o models of IL-13-induced lung pathology and in vitro culture of murine fibroblast cell lines and pri

155 However, in vitro culture of neurons deprives them of their natur

156 Upon in vitro culture, compared to the GFP group, cells from

157 differences between these reticulocytes and in vitro-cultured adult reticulocytes functionally or at

158 collected from infected individuals or from in vitro cultures of P. falciparum, making them prone to

159 Using in vitro cultures of several cell types found in the hea

160 We find that this mAb can enhance the in vitro cytotoxic activity of venetoclcax for CLL cells

161 we utilized high-throughput screening (HTS) in vitro data of PAHs to predict health risks associated

162 Comparatively few in vitro data on antimicrobial susceptibility are availa

163 Adoptive transfer of in vitro differentiated MCs restored thrombosis.

164 tem that supports efficient and reproducible in vitro differentiation and positive selection of conve

165 In vitro differentiation can trigger the development of

166 In vitro differentiation into fibroblasts and smooth mus

167 protocol that describes how to initiate the in vitro differentiation of mouse and human PSCs into ca

168 In vitro differentiation of progenitors transduced with

169 ility of blackberry purees through simulated in vitro digestion was also studied.

170 ermined after their manufacturing and during in vitro digestion.

171 of protein libraries, and should enable the in vitro directed evolution of proteins with designer si

172 PSCs) offers unprecedented opportunities for in vitro disease modeling and personalized cell replacem

173 directly activated CTSB but not trypsinogen in vitro During pancreatitis in pancreas-specific CTSD(f

174 Real-time impedance biosensing verified in vitro early, dose-dependent quantitative decreases in

175 s, we confirm that HDAC6 inhibition augments in vitro efficacy of anti-CD20 mAbs and improves surviva

176 In vitro electrophysiological studies were conducted usi

177 We show that decidualization (even in vitro) enhances the ability to communicate with the f

178 Temporal manipulation of the in vitro environment and growth factors can direct diffe

179 The in vitro enzyme assays indicate that these distinct meta

180 Although early in vitro enzyme assays showed that recombinant BAR and P

181 reen-printed potentiometric immunosensor for in vitro evaluation of Trp consumption and Kyn productio

182 ween kinetochores and microtubules, and some in vitro evidence indicates that the phosphorylation of

183 Here, we report the use of an in vitro evolution approach involving systematic evoluti

184 orheology were rigorously investigated in an in vitro experimental setup that mimics the human circul

185 A recent crystal structure and in vitro experiments highlighted potential residues medi

186 In vitro experiments in human blood suggested that cavit

187 In vitro exposure of human whole blood to PhNHOH and NOB

188 om patients with sPE, which dedifferentiated in vitro, failed to redecidualize in culture.

189 fferentially expressed in vivo compared with in vitro (false discovery rate, </=0.001; 2-fold change)

190 te cleavage and blastocyst development after in-vitro fertilization.

191 Consistent with the in vitro findings, DR6(-/-) animals displayed preserved

192 uscle cells from mouse tracheas were assayed in vitro for signaling pathways.

193 l differences between microtubules assembled in vitro from mammalian or budding yeast tubulin.

194 s, both of which stimulated SRC-2 expression in vitro Furthermore, SRC-2 coactivated the transcriptio

195 tions had wild-type-like fusion levels in an in vitro gB/gH-gL cell fusion assay.

196 TF) decreased by about 50% at the end of the in vitro GID.

197 e clusters were essential for fitness during in vitro growth in three C. jejuni strains, revealing th

198 Based on the in vitro growth study, MOS-III and MOS-IV was found to b

199 nduce autophagy at micromolar concentrations in vitro, have aggregate-clearing activity in a cellular

200 n implicated in the initiation of senescence in vitro Here we show that in a mouse model of prostate

201 In vitro, hnRNP F overexpression stimulated Sirtuin-1 an

202 When activated in vitro, however, IFN-gamma production by naive wild ty

203 r ZauP influenced FtsZ dynamics or bundling, in vitro, however.

204 In vitro, HpRppH converts RNA 5'-triphosphates and dipho

205 y to induce target tissue damage in a unique in vitro human graft-versus-host disease skin explant mo

206 e produced using transglutaminase, and their in vitro IgE reactivity and digestibility under simulate

207 In vitro, IL-17A enhanced IL-13-induced gene expression

208 ntagonism modified PTH secretion in vivo and in vitro, implying roles for these specific miRNAs.

209 of IAPP seeds accelerates Abeta aggregation in vitro in a seeding-like manner and the resulting fibr

210 ntiated primary human airway epithelia (HAE) in vitro In human embryonic kidney HEK293 cells, the tra

211 ing oocytes autonomously synthesized betaine in vitro in the presence of choline, whereas this failed

212 entiation of oligodendrocyte precursor cells in vitro, in animal models, and in human cells.

213 optimize the extracted biological data using in vitro-in vivo correlations.

214 In vitro-in vivo extrapolation (IVIVE) analyses translat

215 in the presence of an antimicrobial peptide in vitro, inactivation of both phoP and Sant_4061 is nec

216 atrix of many different monospecies biofilms in vitro, including some of those produced by oral bacte

217 Sucrose, a tuber-promoting factor in vitro, increases StPP2Ac2b expression.

218 In vitro, increasing the hematocrit increased thrombin g

219 By in vitro infection of gastric epithelial cells with wild

220 In vitro interleukin-4-polarization of human primary mon

221 The estimated in vitro intrinsic clearance (Clint) of TBECH mixture wa

222 l molecular biology of ascovirus replication in vitro is lacking.

223 In vitro, ISG15 deficiency also leads to persistently hi

224 not essential for H3-H4 tetrasome deposition in vitro, it is required for efficient DNA synthesis-cou

225 In vitro laboratory study.

226 ng ribosome affinity purification (TRAP) and in vitro luciferase reporter assay indicate that mir-92a

227 This protocol describes a unique in vitro method for the generation of a 3D human lymphat

228 MutLalpha ATPase, and MutLalpha function in in vitro mismatch repair.

229 ncy and tumourigenesis, we have developed an in vitro model comprising human primary schwannoma cells

230 udy progresses the development of a suitable in vitro model to examine the effects of mechanical stre

231 physiologically relevant cardiac tissue-like in vitro models for mechanistic biological research, dis

232 Developing in vitro models of HIV-1 latency that recapitulate the c

233 ngle-base-pair precision, which allows novel in vitro models of human disease to be generated-e.g., i

234 id cofactors generating infectious prions in in vitro models.

235 cit, in the present study, we established an in vitro mouse brain slice preparation that retains conn

236 there have been increased calls for advanced in vitro multi-cellular models that provide reliable and

237 the base triples reduce telomerase activity in vitro NMR studies also reveal that the pseudoknot doe

238 Using an in vitro optical trapping and fluorescence assay, we fou

239 , and replication of SSPiM OCTA signal in an in vitro phantom.

240 phore with free 9-cis-retinal from Rho in an in vitro phospholipid/detergent bicelle system.

241 There were lower levels of in vitro-polarized TH2 cells from Spi2A knockout mice (P

242 Thiazole 27 showed excellent in vitro properties and a promising mouse PK profile, ma

243 In vitro, purified RPA directly enhances the association

244 In vitro receptor autoradiography was performed with (12

245 Utilizing multi-color TIRF microscopy of in vitro reconstituted F-actin networks, we observed and

246 In vitro reconstitution and in vivo targeting assays sho

247 and characterized at functional level using in vitro reporter assays.

248 nal culture derived from timed pregnant rats in vitro, resulting in a much higher C99 level and C99/C

249 Treatment of the U251 glioma cells with NA in vitro results in reduced invasion, which is accompani

250 Overall, our in vitro results propose a wide repertoire of potential

251 These in vitro results were confirmed in various cell line xen

252 ity, some specific applications ranging from in vitro sensing assays to cellular imaging are separate

253 atory effects in the cellular assay, but not in vitro Sequencing analyses further demonstrated that H

254 CL photoactivation of Cy7 azide in vitro showed significantly higher fluorescence signal

255 ation of this transporter gene revealed that in vitro SLC16A5-silencing altered cellular responses to

256 The aim of this study was to investigate the in vitro starch digestibility of injera and porridge fro

257 /myoepithelial population and an increase in in vitro stem cell activity.

258 rs with micromolar affinity and is saturable in vitro Sterol binding by MpPR-1 requires the presence

259 In vitro studies confirmed an increase in IL-17C mRNA an

260 In vitro studies confirmed the platform's biocompatibili

261 In vitro studies demonstrate that Ct growth inhibition o

262 In vitro studies demonstrate that Ofd1 directly binds Rp

263 In vitro studies demonstrated that senescent-cell condit

264 In vitro studies have demonstrated the importance of apo

265 In vitro studies here show that at the same shift motif

266 on at defined positions that can be used for in vitro studies is highly desirable.

267 In vitro studies of reconstituted E. coli replisomes hav

268 In vitro studies revealed that FTY720 also attenuated 6-

269 I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament ca

270 In vitro studies suggested OG would preferentially form

271 Previous in vitro studies suggested that binding of SH2 and PTB d

272 In vitro study showed more sustained drug release of CM-

273 CHAF1A inhibits NEIL1 initiated repair in vitro Subsequent restoration of the chaperone-BER com

274 uct at 1.65 A resolution, and we compare its in vitro substrate specificity with those of fungal Icp5

275 SBL enzymes, and certain strains demonstrate in vitro susceptibility to these agents, potentially aff

276 Here, we show in a controlled in vitro system that phosphorylation of a membrane prote

277 In our in vitro T cell culture system, MART1-specific CD8 T cel

278 In vitro techniques at the molecular and cellular levels

279 of platelet function and thrombus formation in vitro than chrysin under physiologically relevant con

280 We also showed in vitro that physiologic levels of OSM impair barrier f

281 In vitro, the compounds induce misfolding of chromatin f

282 Given the absence of external causes in vitro, the interplay of structurally differently cons

283 alize or enhance Zika virus (ZIKV) infection in vitro, their contribution to ZIKV infection in vivo r

284 latelets, and cynomolgus platelet activation in vitro These experiments demonstrate that the SEFL mod

285 When recapitulated with purified protein in vitro, this modification completely ablated the activ

286 -1GFP reporter pluripotent stem cells (PSCs) in vitro to generate and isolate human primordial lung p

287 of fast and slow elongating VASP proteins by in vitro total internal reflection fluorescence microsco

288 and its metabolites was then compared using in vitro transporter assays and in vivo microdialysis in

289 was greatly accelerated in vivo compared to in vitro using agitated phosphate buffered saline +0.02%

290 NV), infectivity was significantly inhibited in vitro (using the epithelioma papulosum cyprini [EPC]

291 er, migration of fs120, but not fs188 cells, in vitro was inhibited by B20-4.1.1.

292 ucose using membrane potential sensitive dye in vitro was measured before and after RH.

293 To model hydrostatic pressure-induced edema in vitro, we developed a method of applied pressure to t

294 reement with predictions from determinations in vitro, we discovered a decline of noradrenergic proje

295 s greatly reduced the synthesis of viral RNA in vitro, which was detected only for the 7- and 21-nucl

296 clic peptide inhibitor of C5 cleavage, using in vitro whole-blood assays and an in vivo baboon model

297 e (CAT) tail elongation-can be recapitulated in vitro with a yeast cell-free system.

298 yet was less potent at inhibiting chemotaxis in vitro with an IC50 of 21 nm Furthermore, we observed

299 e N-terminal moiety of MF6p/FhHDM-1 interact in vitro with cell membranes in hemin-preconditioned ery

300 ortical neurons from slow excitotoxic injury in vitro, without influencing NMDA-induced intracellular