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1 ot upon direct exposure of glia to morphine (in vitro).
4 elial electrical resistance in an all-human, in vitro, 3-dimensional, blood-brain barrier model exemp
5 uch timing as demonstrated by animal studies in vitro [3, 4] and in vivo [5, 6], suggesting a causal
12 sed the level of IL-10 production by B cells in vitro, although the frequencies of CD1d(hi) CD5(+) an
13 fect the process of cellular transformation (in vitro) and environmental carcinogenesis (in vivo), in
14 R mutation confers enhanced FcRn interaction in vitro, and Abs harboring either the Q311R or TLQ muta
15 drial biogenesis and function dosed to cells in vitro, and also dosed in vivo to mice and humans.
16 All ILC subsets are functionally competent in vitro, and are sufficient to provide enhanced protect
17 ues can bind interchangeably with each other in vitro, and at least in the fission yeast, heterologou
19 C motif) ligand 2 in neonatal cholangiocytes in vitro, and blockade of the corresponding chemokine (C
20 ed neurons treated with recombinant TNFalpha in vitro, and by repeated intrathecal injection of recom
21 cultured in G-CSF failed to respond to G-CSF in vitro, and Csf3r gene expression could not be detecte
22 mphopoiesis in a non-cell-autonomous fashion in vitro, and depletion of the Hh effector Smoothened (S
23 rreversible growth inhibition and senescence in vitro, and diminishes growth of cell line and patient
24 s (RBCs) demonstrate procoagulant properties in vitro, and elevated hematocrit is associated with red
25 the presence of G4 in human P1-HNF4A-5' UTR in vitro, and establishes a novel working model of stron
26 orescently labelled particles are detectable in vitro, and explore the utility of the method in vivo
27 characterization of cell/tissue development in vitro, and for long-term in vivo monitoring the miner
28 een essential for generating human organoids in vitro, and how organoids are now being used as a prim
29 mutations showed similar behaviors in yeast, in vitro, and in Drosophila, a few showed anomalous beha
30 Systematic profiling of ex vivo (in yeast), in vitro, and in vivo activities of type-2 diacylglycero
32 (NMU), the ligand of NMUR1, activated ILC2s in vitro, and in vivo co-administration of NMU with IL-2
34 biology approach integrating computational, in vitro, and in vivo experiments to identify TRIM25 (tr
35 eceptor trafficking, enhanced cell migration in vitro, and increased the metastatic efficiency of NSC
36 oalveolar lavage macrophages were stimulated in vitro, and iNOS expression and NO production were inv
37 istics for specific peptide binding to cells in vitro, and investigated peak peptide uptake in tumors
38 GFBR3-PLAG1 promotes a tumorigenic phenotype in vitro, and is absent in 723 other salivary gland tumo
39 1 bound fatty acids with micromolar affinity in vitro, and its function was essential for fatty acid
40 cells exhibited sustained clonogenic growth in vitro, and lineage-tracing of Prox1(+) cells revealed
41 hat in vivo SARs differ from those collected in vitro, and most importantly, we identify four UBPs wh
42 ated uptake in HCT116-C19 cells was observed in vitro, and PET/CT imaging of normal mice showed uptak
43 ricted expansion of antigen-pulsed Tfh cells in vitro, and possessed a unique gene expression pattern
44 ated enhanced responses to autologous blasts in vitro, and primed CD56bright cells controlled leukemi
45 o, interacting directly with the RRE and Rev in vitro, and promoting Rev oligomerization in vitro.
46 t-transcriptional assembly of yeast U6 snRNP in vitro, and propose a model for U6 snRNP assembly.
47 lls harboring ALK amplification or mutations in vitro, and resulted in complete and durable responses
48 c80 complex's ability to bind two Dam1 rings in vitro, and results in kinetochore biorientation and m
51 their proliferation and clonogenic capacity in vitro, and suppressed tumor xenograft growth in sever
52 otes osteoblast migration and mineralization in vitro, and systemic administration of PTHrP1-17 augme
53 ymes are capable of polyubiquitylating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1
54 protein is similar in vivo to that observed in vitro, and that, at least for a predominant part of t
55 RAS-binding domain of the adenylate cyclase in vitro, and the cAMP analogue 8-bromo-cyclic AMP parti
56 iciently cleaved DSP into distinct fragments in vitro, and the deletion of Mmp9 caused improper proce
57 ophila, the mutation accelerates aggregation in vitro, and the mutant prion-like domain can substitut
58 al of several glioblastoma neurosphere lines in vitro, and this activity was further augmented by hyp
60 he nonessential proteins affect viral growth in vitro, and two affect virulence in vivo; and (iv) a m
61 ad no apparent defect in platelet activation in vitro, and vessel wall platelet deposition and initia
62 anges in the HA stalk domain replicated well in vitro, and viruses incorporating two of the stalk mut
65 mmune-modulating properties both in vivo and in vitro, as characterized by secretion of both proinfla
66 Furthermore, under Th1 culture conditions in vitro, as well as in an IFN-gamma-rich inflammatory e
70 5-E-VP -modified siRNA to human Argonaute-2 in-vitro, as well as the enhanced silencing in the conte
75 ties of MCs across the MOB and AOB, using an in vitro, brain slice approach in postnatal 15-30 day mi
77 aspase-mediated processing of the prohormone in vitro, but also the ability of prosystemin to trigger
78 sing approach to directing HSC specification in vitro, but current protocols are not capable of gener
79 en derived from human pluripotent stem cells in vitro, but generating a human ovarian follicle remain
80 ct of succinate was observed on cancer cells in vitro, but interestingly, we found that succinate cau
81 ave well documented immunomodulatory effects in vitro, but not following oral administration in human
82 al strains of the H1 and/or H3 virus subtype in vitro, but only KLK5 promoted the infectivity of A/Pu
83 sers at monoamine transporters as determined in vitro, but only methylone and MDC (1, 3 mg/kg, iv) pr
84 d agave Rca form functional hetero-oligomers in vitro, but only the rice isoforms denature at nonperm
85 inib effectively inhibited tumor cell growth in vitro, but the combination of trametinib and BKM120 o
87 siRNAs increases their potency and efficacy in vitro, but when delivered systemically to mice, the 5
90 ano-enzymatic pathway of TTR fibrillogenesis in vitro, catalysed by selective proteolytic cleavage, w
91 h destabilized the N-terminal Fe4 S4 cluster in vitro, caused mild growth defects and a significant d
95 We stimulated human NK cells through CD16a in vitro, characterized CD16a-inducible transcripts, and
96 Cs were isolated from mouse hearts, expanded in vitro, characterized, and evaluated for therapeutic e
101 refer neutral over anionic membrane surfaces in vitro, consistent with their localization to the earl
102 he C-terminal region of TPX2 regulates Kif15 in vitro, contributes to motor localization in cells, an
110 A systematic approach involving in silico, in vitro, ex vivo and in vivo studies is employed to ide
111 nhancer and SE repertoires in cultured VSMCs in vitro, ex vivo, and in AngII-infused mice aortas in v
115 fferentially expressed in vivo compared with in vitro (false discovery rate, </=0.001; 2-fold change)
117 cytoskeletal proteins has been demonstrated in vitro, fluorescence recovery after photobleaching ana
118 human neurons may be useful for studying VZV in vitro, for growing preparations of virus with high ti
122 osphate) promote alpha-synuclein aggregation in vitro, glucosylsphingosine triggers the formation of
123 nduce autophagy at micromolar concentrations in vitro, have aggregate-clearing activity in a cellular
124 ng has no effect on radiation-induced EndoMT in vitro, Hey2 overexpression is sufficient to induce ph
129 s virus (MHV)-A59 infection both in vivo and in vitro; however, its mechanism and association with lo
130 by islet cells and induced their destruction in vitro; however, passive transfer of the same DSAs did
136 hese proteins are essential for viral growth in vitro; (iii) seven of the nonessential proteins affec
142 ntagonism modified PTH secretion in vivo and in vitro, implying roles for these specific miRNAs.
144 exhibits selectivity for hypoxic activation in vitro, in living cells, and in multiple disease model
145 sion of retinal degeneration in models of RP in vitro, in vivo analyses were not possible with PR1.
146 displays broad-spectrum anticancer activity in vitro, in vivo in preclinical animal models, and in a
148 f the interesting properties of graphene for in vitro, in vivo, and point-of-care electrochemical bio
149 in the presence of an antimicrobial peptide in vitro, inactivation of both phoP and Sant_4061 is nec
150 a transition between distinct MK populations in vitro, including one that is primed for platelet rele
151 s also enhanced P. mirabilis urease activity in vitro, including recent clinical isolates of Escheric
152 suppressed neutrophil activation ex vivo and in vitro, including reduced l-selectin shedding, oxidati
153 atrix of many different monospecies biofilms in vitro, including some of those produced by oral bacte
158 -induced maturation of osteoclast-precursors in vitro, indicate the commensal microbiota induces sust
159 lations exhibited erosion-controlled release in vitro, indicated by similar polymer mass loss kinetic
160 interact with known paramyxoviral receptors in vitro, indicating an independence from well-character
161 uced smaller neurospheres than control cells in vitro, indicating reduction of self-renewal and expan
162 D4(+)LAP(+)Foxp3(-) T cells were suppressive in vitro, inhibiting proliferation of naive CD4(+) T cel
166 hat while the ISR protects OPCs from hypoxia in vitro, it does not appear to play a major role in eit
167 not essential for H3-H4 tetrasome deposition in vitro, it is required for efficient DNA synthesis-cou
168 the functions of dendritic cells in vivo and in vitro, IVM impaired T-cell activation, proliferation,
169 essed its pharmacological properties through in vitro (kinase assay), ex vivo (human liver microsomes
172 s T cell activation and IFN-gamma production in vitro, leading to a significant reduction in tumour g
178 so strongly inhibits metallo-beta-lactamases in vitro, major contributors to clinical carbapenem resi
179 A total of only 520 compounds were tested in vitro, making this method broadly applicable for tool
185 I3K pathway, we assessed Treg cell induction in vitro, mitochondrial depolarization, and recruitment
187 rt morphology, biochemistry and pharmacology in vitro, offering a promising alternative to animals an
189 ctivity of guarana extracts, after digestion in vitro, on carbohydrates-metabolism enzymes and to ass
190 fibrils by prion-like seeded polymerization in vitro, only some are transmissible and pathogenic in
191 cological inhibition or lentiviral silencing in vitro, or by genetic inactivation in neurons in vivo,
192 s1-Cas2 alone integrates spacers efficiently in vitro; other Cas proteins (such as Cas9 and Csn2) hav
193 tly to aromatase inhibition both in vivo and in vitro, our findings suggest that E2 signaling in BLA
200 y, rIFN-lambdas enhanced epithelial barriers in vitro, preventing transcellular bacteria disseminatio
202 and gastruloids have recently been generated in vitro, providing a unique opportunity to explore comp
203 resulted in severe defects both in vivo and in vitro, providing additional support for this unpreced
206 h concentrated platelets from healthy donors in vitro, raising platelet counts by 0% (unsupplemented
207 mitant dominant-negative effect on other E3s in vitro, raising the possibility that short circuiting
209 tromal cells for normal collagen remodelling in vitro, regulating fibroblast interaction and engageme
210 element that is critical to PD-1 expression in vitro, responds to NFATc1, FoxO1, and/or NF-kappaB si
211 nal culture derived from timed pregnant rats in vitro, resulting in a much higher C99 level and C99/C
212 LRRK2 directly phosphorylates synaptojanin1 in vitro, resulting in the disruption of endophilin-syna
218 orkhead box P3 (Foxp3)(-) regulatory T cells in vitro, such that beta subunit of IL-27 (Ebi)(-/-) (ie
220 strong immunoreactivity with patient T cells in vitro, suggesting long-lasting immunological memory.
221 establishment of several gammaherpesviruses in vitro, suggesting that ATM is proviral in the context
222 in the white flour fraction was bioavailable in vitro, suggesting that food products made from the bi
223 m, effectively inhibited phenazine reduction in vitro, suggesting that most phenazine reduction deriv
224 in vivo, STAT4 failed to induce EMT directly in vitro, suggesting that STAT4 might mediate EMT proces
225 ledge, that HsPrp40Ap interacts with centrin in vitro, supporting a coupled functional role for these
227 o examined the activity of the three enzymes in vitro; surprisingly, all three are active toward oxam
233 n vivo and on primary human pulp fibroblasts in vitro, the authors reveal that C5L2 and C5aR are co-e
236 ad to modulation of their chaperone activity in vitro, the in vivo functions of alphaB-crystallin in
237 scosity and diffusion on a single cell level in vitro, the in vivo viscosity monitoring has not yet b
238 e that, using the RHOA biosensor in vivo and in vitro, the initiation of NCC polarization is accompan
244 ast Rad51 has been extensively characterized in vitro, the stringency of its search and sensitivity t
245 alize or enhance Zika virus (ZIKV) infection in vitro, their contribution to ZIKV infection in vivo r
250 ells generally display a growth disadvantage in vitro, they grow significantly better in low adherenc
252 When recapitulated with purified protein in vitro, this modification completely ablated the activ
253 Sertoli cells in a mitotically active state in vitro, thus enabling transfection experiments that al
254 promotes the degradation of mutant myocilin in vitro, to date no Grp94-selective inhibitors have bee
255 a facultative intracellular bacterium known, in vitro, to invade a large diversity of cells through t
256 transmembrane protein which has been shown, in vitro, to participate in the cellular efflux of desmo
257 ttachment factors for AKAV and SBV, at least in vitro, to promote virus replication in susceptible ce
258 though hPL inhibits GSTP1 enzymatic activity in vitro, treatment of cells susceptible to PL with hPL
260 peptides disrupted the targeted interaction in vitro; two act by binding to CMG2 while one binds PA.
261 ptible mice and inhibited by IL-4R-signaling in vitro, uncoupling parasite killing from expulsion mec
262 ts, and biochemical characterization of DH10 in vitro, using polyketide substrate mimics with varying
263 NV), infectivity was significantly inhibited in vitro (using the epithelioma papulosum cyprini [EPC]
266 s E. histolytica does not readily form cysts in vitro, we assessed membrane trafficking gene expressi
267 To study these host-microbe interactions in vitro, we developed a human three-dimensional (3-D) e
268 To model hydrostatic pressure-induced edema in vitro, we developed a method of applied pressure to t
269 reement with predictions from determinations in vitro, we discovered a decline of noradrenergic proje
270 cessfully reconstituting Search-Capture-Pull in vitro, we discovered that formin Cdc12 is a mechanose
271 in cholangiocytes and hepatic stellate cells in vitro, we evaluated angiogenesis and fibrosis gene ex
273 le assays for measuring honey's cytotoxicity in vitro, we found honey is cytotoxic towards prostate c
277 nement and screening for biological activity in vitro, we identified 21 hit compounds which inhibited
278 rt-butyl hydroperoxide and hypochlorous acid in vitro, we identified additional covalent oxidative mo
279 Corroborating the results in RB-KO organoids in vitro, we observed ectopically localized Tuj1(+) cell
283 nation of analytical and biophysical methods in vitro, we tested whether EVs isolated from pancreatic
284 rimary hepatocytes facilitates HBV infection in vitro, where all replicative intermediates including
285 icient attL x attR recombination in vivo and in vitro, whereas attP x attB recombination efficiency i
286 ls with GATA2 mutation proliferated normally in vitro, whereas lineage-negative progenitors displayed
287 M, providing a substrate for monocytic cells in vitro, whereas lung fibroblasts from Vcan(-/-) mice d
288 s LD abundance and reduces TNBC 2D migration in vitro, which can be partially rescued by the ACSL inh
289 generate dendritic action potentials (DAPs) in vitro, which can profoundly influence neural computat
290 tion of tight junctions in endothelial cells in vitro, which is blocked by pharmacological inhibition
291 ncogene c-Myc and the neural ESC marker CDK2 in vitro, which was accompanied by altered expression of
292 s greatly reduced the synthesis of viral RNA in vitro, which was detected only for the 7- and 21-nucl
293 ipitate complex (IP) displayed MMEJ activity in vitro, which was significantly elevated after irradia
294 , these cells show increased differentiation in vitro, with rapid loss of HSC-enriched LSK cells.
295 dy levels triggered eosinophil degranulation in vitro, with release of extensive histone-rich extrace
296 ortical neurons from slow excitotoxic injury in vitro, without influencing NMDA-induced intracellular
300 thelial cells can be propagated indefinitely in vitro, yet retain the capacity to become fully differ
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